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I have long held interest in understanding how cell identity is acquired, maintained, and ultimately modified or reversed. During my PhD, I made my first contributions to the field of cellular reprogramming by establishing cell fusion and heterokaryons to study mechanisms of reprogramming towards pluripotency. Of note, I implicated the essential role of Polycomb repression in reprogramming. During my postdoc, I applied concepts of cell reprogramming to hematopoeisis for the first time. I identified a combination of transcription factors that induces hemogenesis and established that reprogramming approaches can inform the developmental specification of hematopoietic stem cells. Afterwards, my independent research group has shown that cooperative transcription factor binding mediates hemogenesis and implicated GATA2 mitotic bookmarking in vivo for the first time (Silvério-Alves, in revision Nature Communications). My group also pioneered cell fate reprogramming approaches in immunology with induced dendritic cells. We have used single-cell genomics to map the induction of dendritic cells from human somatic cells and informed the dynamics and heterogeneity of the process to massively increase reprogramming efficiency. We have also uncovered the chromatin engagement rules for the instructive transcription factors to elicit reprogramming. We used this information to directly induce dendritic cell fate in cancer cells as a strategy to promote tumor antigen presentation and restore tumor immunogenicity (Zimmermannova et al, in revision Science Immunology). With the vision of harnessing dendritic cell reprogramming for cancer immunotherapy that could be translated to an improvement in the lives of cancer patients I co-founded Asgard Therapeutics and BRT Blood Reprogramming Technologies together with 2 members of my research group. The conceptual shift in immune cell reprogramming creates exciting opportunities for novel gene and cell therapies that harness specific modules of the immune response, which my research group at Coimbra and Lund Universities is exploring with a focus on the unique features of myeloid and lymphoid immune cell populations.
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Identificação

Identificação pessoal

Nome completo
Carlos Filipe Ribeiro Lemos Pereira

Nomes de citação

  • Pereira, Carlos-Filipe

Identificadores de autor

Ciência ID
5611-D049-ABC6
ORCID iD
0000-0002-9724-1382

Endereços de correio eletrónico

  • filipe.pereira@cnc.uc.pt (Profissional)

Telefones

Telemóvel
  • 962664340 (Profissional)

Moradas

  • Parque Tecnológico de Cantanhede, Núcleo 4, Lote 8, 3060-197, Cantanhede, Cantanhede, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Imunologia

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Formação
Grau Classificação
2004/09/01 - 2009/02/01
Concluído
 PhD in Biomedical Sciences, Imperial College School of Medicine, London, UK (Doutoramento)
Especialização em Title: Epigenetic events underlying somatic cell reprogramming.
Imperial College Faculty of Medicine - Hammersmith Campus, Reino Unido
"Epigenetic events underlying somatic cell reprogramming" (TESE/DISSERTAÇÃO)
 Ph.D. thesis accepted without modifications.
1998/09/01 - 2002/07/31
Concluído
 Biologia (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
"n/a" (TESE/DISSERTAÇÃO)
 16
1998/07/31
Concluído
 High school education (Ensino secundário)
Agrupamento de escolas de Muralhas do Minho, Valença, Portugal
 18
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2017/09/01 - Atual Investigador principal (carreira) (Investigação) Lunds universitet Institutionen för laboratoriemedicin Lund, Suécia
Lunds Universitet Arbets- och miljömedicin, Suécia
2015/02/18 - Atual Investigador Auxiliar (carreira) (Investigação) Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
Projetos

Bolsa

Designação Financiadores
2024/01/01 - Atual Functional chemical reprogramming of cancer cells to induce antitumor immunity - RESYNC
RESYNC
Investigador responsável
Lunds Universitet, Suécia
 European Innovation Council
Em curso
2021/01/01 - 2026/12/31 Inducing antigen presentation in tumor cells with direct cell reprogramming
2020-00615
Investigador responsável
Vetenskapsradet
2023/03/01 - 2026/02/28 Using dendritic cell reprogramming to identify novel immunotherapy targets
DC1Drug
Investigador responsável
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2023/01/01 - 2025/12/31 REPROcode: a single-cell platform to define transcription factors for immune cell reprogramming
ReproCODE
Lunds Universitet, Suécia
 Novo Nordisk Fonden
Em curso
2020/06/01 - 2025/05/31 Harnessing dendritic cell reprogramming for cancer immunotherapy
866448
Investigador responsável
Lunds Universitet, Suécia
 European Research Council
Em curso
2023/06/01 - 2024/12/31 Neoantigen Identification with Dendritic Cell Reprogramming - NeoIDC
NeoIDC
Investigador responsável
Lunds Universitet, Suécia
 European Research Council
Em curso
2021/01/01 - 2023/12/31 DiverDC: Understanding dendritic cell diversity with cell reprogramming
PTDC/MED-IMU/4520/2020
Investigador responsável
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2018/06 - 2021/12/31 ReproDC: Generating Antigen Presenting Cells by Direct Reprogramming
CENTRO-01-0145-FEDER-030013
Investigador responsável
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2019/09/01 - 2021/08/31 Elucidating the Mechanisms of Hematopoietic Reprogramming.
194-694
Investigador responsável
Lunds Universitet, Suécia
 Stiftelsen Olle Engkvist Byggmästare
Em curso
2020/06/01 - 2021/05/31 Inducing NK cells with direct cell reprogramming
0062919
Investigador responsável
Lund Universitet Institutionen för laboratoriemedicin Malmö, Suécia
2018/07/01 - 2021/03/31 ReProgram: Reconstructing the Program of Cancer Stem Cells
POCI-01-0145-FEDER-029017
Investigador responsável
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2020/03/01 - 2021/02/28 Dendritic Cell Therapy
0053036
Investigador responsável
Lund Universitet Institutionen för laboratoriemedicin Malmö, Suécia
 Novo Nordisk Fonden
Concluído
2017/01 - 2021/02/28 Consortium CANCEL_STEM: Tackling CANcer STEM CELls: a challenge and an opportunity to advance in anti-cancer therapy
CANCEL_STEM
Investigador responsável
Fundação para a Ciência e a Tecnologia
Concluído
2019/01 - 2020/12/31 Generating Dendritic Cells by Direct Cell Reprogramming
2018-02442
Investigador responsável
Lunds Universitet, Suécia
 Vetenskapsradet
Concluído
2018/01 - 2020/12 Generating Dendritic Cells by Direct Reprogramming
CAN 2017/745
Investigador responsável
Lunds Universitet, Suécia
 Cancerfonden
Concluído
2019/09/01 - 2020/08/31 Mass spectrometry-based immunopeptidomic profiling in stem cells, disease and reprogramming.
StemTherapy Methods Grant.
Lund Universitet Institutionen för laboratoriemedicin Malmö, Suécia
Concluído
2018/03/01 - 2020/02/29 AAC Grant for protecting intellectual property
04/SAICT/2017
Investigador responsável
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2015/12/01 - 2018/12/01 Hemoinduction: mechanisms underlying hemogenic induction in human fibrobalsts
PTDC/BIM-MED/0075/2014
Investigador responsável
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2018/01 - 2018/12 Generating Dendritic Cells by Direct Reprogramming
20180864
Investigador responsável
Lunds Universitet, Suécia
 Crafoordska Stiftelsen
Concluído

Projeto

Designação Financiadores
2017/09 - 2024/12/31 Wallenberg Center for Molecular Medicine 4-year career package
WCMMLUPEREIRA
Investigador responsável
Wallenberg Centre for Molecular Medicine
Em curso
2019/10/01 - 2022/09/30 Generating T Cells from Fibroblasts and Mesenchymal Stem Cells
AUTO-PEREIRA
Investigador responsável
Lunds Universitet, Suécia
 Autolus Ltd
Em curso
Produções

Publicações

Artigo em revista
  1. Rita Silvério-Alves; Ilia Kurochkin; Anna Rydström; Camila Vazquez Echegaray; Jakob Haider; Matthew Nicholls; Christina Rode; et al. "GATA2 mitotic bookmarking is required for definitive haematopoiesis". Nature Communications 14 4645 (2023): https://www.nature.com/articles/s41467-023-40391-x.
    Acesso aberto • 10.1038/s41467-023-40391-x
  2. Olga Zimmermannova; Alexandra G. Ferreira; Ervin Ascic; Marta Velasco Santiago; Ilia Kurochkin; Morten Hansen; Özcan Met; et al. "Restoring tumor immunogenicity with dendritic cell reprogramming". Science Immunology 8 85 (2023):
    10.1126/sciimmunol.add4817
  3. Lee, D.-F.; Pereira, C.-F.. "Reprogramming Stars #10: Modeling Cancer with Cellular Reprogramming - An Interview with Dr. Dung-Fang Lee". Cellular Reprogramming 25 1 (2023): 2-6. http://www.scopus.com/inward/record.url?eid=2-s2.0-85148250551&partnerID=MN8TOARS.
    10.1089/cell.2023.29081.dfl
  4. Diana Pádua; Paula Figueira; Mariana Pinto; André Filipe Maia; Joana Peixoto; Raquel T. Lima; António Pombinho; et al. "High-Throughput Drug Screening Revealed That Ciclopirox Olamine Can Engender Gastric Cancer Stem-like Cells". Cancers 15 (2023): 4406.
    Acesso aberto • 10.3390/cancers15174406
  5. Olga Zimmermannova; Alexandra Gabriela Ferreira ; Pereira, Carlos-Filipe. "Orchestrating an immune response to cancer with cellular reprogramming". Genes & Immunity (2023):
  6. Alexandra G Ferreira; Olga Zimmermannova; Ilia Kurochkin; Ervin Ascic; Fritiof Åkerström; Pereira, Carlos-Filipe. "Reprogramming Cancer Cells to Antigen-presenting Cells". Bio-Protocol (2023):
  7. Leigh, Nicholas D.; Pereira, Carlos-Filipe. "Reprogramming Stars #5: Regeneration, a Natural Reprogramming Process—An Interview with Dr. Nicholas Leigh". Cellular Reprogramming 24 1 (2022): 2-8. http://dx.doi.org/10.1089/cell.2022.29055.nl.
    10.1089/cell.2022.29055.nl
  8. Rosa, F.F.; Pires, C.F.; Kurochkin, I.; Halitzki, E.; Zahan, T.; Arh, N.; Zimmermannová, O.; et al. "Single-cell transcriptional profiling informs efficient reprogramming of human somatic cells to cross-presenting dendritic cells". Science immunology 7 69 (2022): eabg5539-eabg5539. http://www.scopus.com/inward/record.url?eid=2-s2.0-85125875360&partnerID=MN8TOARS.
    10.1126/sciimmunol.abg5539
  9. Wu, J.; Pereira, C.-F.; Lu, Y.R.. "Reprogramming Stars #7: Dynamic Pluripotent Stem Cell States and Their Applications-An Interview with Dr. Jun Wu". Cellular Reprogramming 24 3 (2022): 105-110. http://www.scopus.com/inward/record.url?eid=2-s2.0-85132269580&partnerID=MN8TOARS.
    10.1089/cell.2022.29064.jc
  10. Pires, C.F.; Pereira, C.-F.. "Reprogramming Stars #6: A Venture Based in Cellular Reprogramming-An Interview with Dr. Cristiana Pires". Cellular Reprogramming 24 2 (2022): 57-62. http://www.scopus.com/inward/record.url?eid=2-s2.0-85127473849&partnerID=MN8TOARS.
    10.1089/cell.2022.29061.cp
  11. Pereira, C.-F.. "Call for Special Issue Papers: Cellular Reprogramming 25th Anniversary Deadline for Manuscript Submission: April 30, 2023". Cellular reprogramming 24 6 (2022): 315-316. http://www.scopus.com/inward/record.url?eid=2-s2.0-85144584647&partnerID=MN8TOARS.
    10.1089/cell.2022.29073.cfp
  12. Galloway, K.E.; Pereira, C.-F.. "Reprogramming Stars #8: A Synthetic Biology Approach to Cellular Reprogramming - An Interview with Dr. Katie Galloway". Cellular Reprogramming 24 4 (2022): 151-162. http://www.scopus.com/inward/record.url?eid=2-s2.0-85136909415&partnerID=MN8TOARS.
    10.1089/cell.2022.29068.kg
  13. Fossati, V.; Pereira, C.-F.. "Reprogramming Stars #9: Spacing Out Cellular Reprogramming - An Interview with Dr. Valentina Fossati". Cellular Reprogramming 107 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85144584650&partnerID=MN8TOARS.
    10.1089/cell.2022.29074.vf
  14. Pádua, Diana; Pinto, Débora Filipa; Figueira, Paula; Pereira, Carlos Filipe; Almeida, Raquel; Mesquita, Patrícia. "HMGA1 Has Predictive Value in Response to Chemotherapy in Gastric Cancer". Current Oncology 29 1 (2021): 56-67. http://dx.doi.org/10.3390/curroncol29010005.
    10.3390/curroncol29010005
  15. Parmar, Malin; Pereira, Carlos-Filipe. "Reprogramming Stars #4: A Reprogramming Approach for Parkinson's Disease—An Interview with Dr. Malin Parmar". Cellular Reprogramming 23 6 (2021): 319-325. http://dx.doi.org/10.1089/cell.2021.29049.mp.
    10.1089/cell.2021.29049.mp
  16. Kaji, Keisuke; Pereira, Carlos-Filipe. "Reprogramming Stars #3: Mechanisms of iPSC Reprogramming—An Interview with Dr. Keisuke Kaji". Cellular Reprogramming 23 5 (2021): 264-269. http://dx.doi.org/10.1089/cell.2021.29046.kk.
    10.1089/cell.2021.29046.kk
  17. Ahlenius, Henrik; Pereira, Carlos-Filipe. "Reprogramming Stars #2: Reprogramming Towards Neural Lineages—An Interview with Dr. Henrik Ahlenius". Cellular Reprogramming 23 4 (2021): 200-205. http://dx.doi.org/10.1089/cell.2021.29044.ha.
    10.1089/cell.2021.29044.ha
  18. Zimmermannova, Olga; Caiado, Inês; Ferreira, Alexandra G.; Pereira, Carlos-Filipe. "Cell Fate Reprogramming in the Era of Cancer Immunotherapy". Frontiers in Immunology 12 (2021): http://dx.doi.org/10.3389/fimmu.2021.714822.
    10.3389/fimmu.2021.714822
  19. Pereira, Carlos-Filipe. "Reprogramming, The Journal". Cellular Reprogramming (2021): http://dx.doi.org/10.1089/cell.2021.0036.
    10.1089/cell.2021.0036
  20. Tsubouchi, Tomomi; Pereira, Carlos-Filipe. "Reprogramming Stars #1: Genome Programming Through the Cell Cycle—An Interview with Dr. Tomomi Tsubouchi". Cellular Reprogramming 23 3 (2021): 153-157. http://dx.doi.org/10.1089/cell.2021.29039.tt.
    10.1089/cell.2021.29039.tt
  21. Pereira, Carlos-Filipe. "Ontogenic Shifts in Cellular Fate are Linked to Proteotype Changes in Lineage-Biased Hematopoietic Progenitor Cells". Cell Reports (2021):
    No prelo
  22. Ulmert, Isabel; Henriques-Oliveira, Luís; Pereira, Carlos-Filipe; Lahl, Katharina. "Mononuclear phagocyte regulation by the transcription factor Blimp-1 in health and disease". Immunology 161 4 (2020): 303-313. http://dx.doi.org/10.1111/imm.13249.
    10.1111/imm.13249
  23. Pádua, Diana; Barros, Rita; Amaral, Ana Luísa; Mesquita, Patrícia; Freire, Ana Filipa; Sousa, Mafalda; Maia, André Filipe; et al. "A SOX2 Reporter System Identifies Gastric Cancer Stem-Like Cells Sensitive to Monensin". Cancers 12 2 (2020): 495. http://dx.doi.org/10.3390/cancers12020495.
    10.3390/cancers12020495
  24. Rosa, Fábio; Pires, Cristiana; Zimmermannova, Olga; Pereira, Carlos-Filipe. "Direct Reprogramming of Mouse Embryonic Fibroblasts to Conventional Type 1 Dendritic Cells by Enforced Expression of Transcription Factors". BIO-PROTOCOL 10 10 (2020): http://dx.doi.org/10.21769/bioprotoc.3619.
    10.21769/bioprotoc.3619
  25. Daniel, M.G.; Sachs, D.; Bernitz, J.M.; Fstkchyan, Y.; Rapp, K.; Satija, N.; Law, K.; et al. "Induction of human hemogenesis in adult fibroblasts by defined factors and hematopoietic coculture". FEBS Letters 593 23 (2019): 3266-3287. http://www.scopus.com/inward/record.url?eid=2-s2.0-85074051202&partnerID=MN8TOARS.
    10.1002/1873-3468.13621
  26. Silvério-Alves, R.; Gomes, A.M.; Kurochkin, I.; Moore, K.A.; Pereira, C.-F.. "Hemogenic Reprogramming of Human Fibroblasts by Enforced Expression of Transcription Factors". Journal of visualized experiments : JoVE 153 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85075191300&partnerID=MN8TOARS.
    10.3791/60112
  27. Pires, C.F.; Rosa, F.F.; Kurochkin, I.; Pereira, C.-F.. "Understanding and Modulating Immunity With Cell Reprogramming". Frontiers in Immunology 10 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85077260284&partnerID=MN8TOARS.
    10.3389/fimmu.2019.02809
  28. Andersson, R.; Pereira, C.-F.; Bauden, M.; Ansari, D.. "Is immunotherapy the holy grail for pancreatic cancer?". Immunotherapy 11 17 (2019): 1435-1438. http://www.scopus.com/inward/record.url?eid=2-s2.0-85076450369&partnerID=MN8TOARS.
    10.2217/imt-2019-0164
  29. Gomes, Andreia M.; Kurochkin, Ilia; Chang, Betty; Daniel, Michael; Law, Kenneth; Satija, Namita; Lachmann, Alexander; et al. "Cooperative Transcription Factor Induction Mediates Hemogenic Reprogramming". Cell Reports 25 10 (2018): 2821-+. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000452894600018&KeyUID=WOS:000452894600018.
    10.1016/j.celrep.2018.11.032
  30. Rosa, Fabio F.; Pires, Cristiana F.; Kurochkin, Ilia; Ferreira, Alexandra G.; Gomes, Andreia M.; Palma, Luis G.; Shaiv, Kritika; et al. "Direct reprogramming of fibroblasts into antigen-presenting dendritic cells". Science Immunology 3 30 (2018): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000452571800002&KeyUID=WOS:000452571800002.
    10.1126/sciimmunol.aau4292
  31. Ivanova, Natalia; Pereira, Carlos-Filipe; Lee, Dung-Fang. "Ihor R. Lemischka (1953-2017)". Cell Stem Cell 22 1 (2018): 16-+. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000419306500008&KeyUID=WOS:000419306500008.
    10.1016/j.stem.2017.12.015
  32. Gomes, A.; Pereira, C. -F.; Chang, B.; Kurochkin, I.; Daniel, M.; Law, K.; Satija, N.; et al. "INDUCTION OF HEMOGENIC REPROGRAMMING IN HUMAN FIBROBLASTS". Haematologica 102 (2017): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000404127006340&KeyUID=WOS:000404127006340.
  33. Vazão, H.; Rosa, S.; Barata, T.; Costa, R.; Pitrez, P.R.; Honório, I.; De Vries, M.R.; et al. "High-throughput identification of small molecules that affect human embryonic vascular development". Proceedings of the National Academy of Sciences of the United States of America 114 15 (2017): E3022-E3031. http://www.scopus.com/inward/record.url?eid=2-s2.0-85035214278&partnerID=MN8TOARS.
    10.1073/pnas.1617451114
  34. Freire, A.G.; Waghray, A.; Soares-da-Silva, F.; Resende, T.P.; Lee, D.-F.; Pereira, C.-F.; Nascimento, D.S.; Lemischka, I.R.; Pinto-do-Ó, P.. "Transient HES5 Activity Instructs Mesodermal Cells toward a Cardiac Fate". Stem Cell Reports 9 1 (2017): 136-148. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021126795&partnerID=MN8TOARS.
    10.1016/j.stemcr.2017.05.025
  35. Agnete Kirkeby; Thomas Perlmann; Carlos-Filipe Pereira. "The stem cell niche finds its true north". Development 143 16 (2016): 2877-2881. https://doi.org/10.1242/dev.140095.
    10.1242/dev.140095
  36. Pereira, C.-F.; Chang, B.; Gomes, A.; Bernitz, J.; Papatsenko, D.; Niu, X.; Swiers, G.; et al. "Hematopoietic Reprogramming In Vitro Informs In Vivo Identification of Hemogenic Precursors to Definitive Hematopoietic Stem Cells". Developmental Cell 36 5 (2016): 525-539. http://www.scopus.com/inward/record.url?eid=2-s2.0-84959312876&partnerID=MN8TOARS.
    10.1016/j.devcel.2016.02.011
  37. Gomes, Andreia; Pereira, Carlos-Filipe; Papatsenko, Dmitri; Moore, Kateri Ann; Lemischka, Ihor. "MECHANISMS UNDERLYING HUMAN HEMOGENIC REPROGRAMMING". Experimental Hematology 44 9 (2016): S75-S76. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000382184600129&KeyUID=WOS:000382184600129.
    10.1016/j.exphem.2016.06.144
  38. Daniel, Michael; Fstkchyan, Yesai; Gomes, Andreia; Pereira, Carlos-Filipe; Lemischka, Ihor; Moore, Kateri Ann. "ZERO FOOTPRINT INDUCTION OF HUMAN HEMOGENESIS TO STUDY PATHOLOGIC DEVELOPMENTAL HEMATOPOIESIS IN FANCONI ANEMIA". Experimental Hematology 44 9 (2016): S65-S65. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000382184600098&KeyUID=WOS:000382184600098.
    10.1016/j.exphem.2016.06.112
  39. Daniel, M.G.; Pereira, C.-F.; Bernitz, J.M.; Lemischka, I.R.; Moore, K.. "Reprogramming mouse embryonic fibroblasts with transcription factors to induce a hemogenic program". Journal of Visualized Experiments 2016 118 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-85015946426&partnerID=MN8TOARS.
    10.3791/54372
  40. Daniel MG; Pereira CF; Lemischka IR; Moore KA. "Making a Hematopoietic Stem Cell.". (2015): http://europepmc.org/abstract/med/26526106.
    10.1016/j.tcb.2015.10.002
  41. Waghray, A.; Saiz, N.; Jayaprakash, A.D.; Freire, A.G.; Papatsenko, D.; Pereira, C.-F.; Lee, D.-F.; et al. "Tbx3 Controls Dppa3 Levels and Exit from Pluripotency toward Mesoderm". Stem Cell Reports 5 1 (2015): 97-110. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937523983&partnerID=MN8TOARS.
    10.1016/j.stemcr.2015.05.009
  42. Pereira, C.-F.; Lemischka, I.R.; Moore, K.. "'From blood to blood': De-differentiation of hematopoietic progenitors to stem cells". EMBO Journal 33 14 (2014): 1511-1513. http://www.scopus.com/inward/record.url?eid=2-s2.0-84904561142&partnerID=MN8TOARS.
    10.15252/embj.201488980
  43. Pereira, C.-F.; Lemischka, I.R.; Moore, K.. ""There will be blood" from fibroblasts". Cell Cycle 13 3 (2014): 335-336. http://www.scopus.com/inward/record.url?eid=2-s2.0-84896884486&partnerID=MN8TOARS.
    10.4161/cc.27507
  44. Pereira, Carlos-Filipe; Chang, Betty; Niu, Xiaohong; Gomes, Andreia; Swiers, Gemma; Azzoni, Emanuele; Schaniel, Christoph; et al. "DIRECT CONVERSION FROM MOUSE FIBROBLASTS INFORMS THE IDENTIFICATION OF HEMOGENIC PRECURSOR CELLS IN VIVO". Experimental Hematology 42 8 (2014): S55-S55. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000340344300196&KeyUID=WOS:000340344300196.
  45. Pereira, Carlos-Filipe; Chang, Betty; Qiu, Jiajing; Niu, Xiaohong; Papatsenko, Dmitri; Hendry, Caroline E; Clark, Neil R; et al. "Induction of a hemogenic program in mouse fibroblasts.". Cell stem cell 13 2 (2013): 205-18.
    10.1016/j.stem.2013.05.024
  46. Lee, Dung-Fang; Su, Jie; Ang, Yen-Sin; Carvajal-Vergara, Xonia; Mulero-Navarro, Sonia; Pereira, Carlos F.; Gingold, Julian; et al. "Regulation of Embryonic and Induced Pluripotency by Aurora Kinase-p53 Signaling". Cell Stem Cell 11 2 (2012): 179-194.
    10.1016/j.stem.2012.05.020
  47. Fidalgo, Miguel; Faiola, Francesco; Pereira, Carlos-Filipe; Ding, Junjun; Saunders, Arven; Gingold, Julian; Schaniel, Christoph; et al. "Zfp281 mediates Nanog autorepression through recruitment of the NuRD complex and inhibits somatic cell reprogramming". Proceedings of the National Academy of Sciences of the United States of America 109 40 (2012): 16202-16207.
    10.1073/pnas.1208533109
  48. Piccolo, Francesco M.; Pereira, Carlos F.; Cantone, Irene; Brown, Karen; Tsubouchi, Tomomi; Soza-Ried, Jorge; Merkenschlager, Matthias; Fisher, Amanda G.. "Using heterokaryons to understand pluripotency and reprogramming". Philosophical Transactions of the Royal Society B-Biological Sciences 366 1575 (2011): 2260-2265.
    10.1098/rstb.2011.0004
  49. Santos, Joana; Pereira, C. Filipe; Di-Gregorio, Aida; Spruce, Thomas; Alder, Olivia; Rodriguez, Tristan; Azuara, Veronique; Merkenschlager, Matthias; Fisher, Amanda G.. "Differences in the epigenetic and reprogramming properties of pluripotent and extra-embryonic stem cells implicate chromatin remodelling as an important early event in the developing mouse embryo". Epigenetics & Chromatin 3 (2010):
    10.1186/1756-8935-3-1
  50. Kanhere, Aditi; Viiri, Keijo; Araujo, Carla C.; Rasaiyaah, Jane; Bouwman, Russell D.; Whyte, Warren A.; Pereira, C. Filipe; et al. "Short RNAs Are Transcribed from Repressed Polycomb Target Genes and Interact with Polycomb Repressive Complex-2". Molecular Cell 38 5 (2010): 675-688.
    10.1016/j.molcel.2010.03.019
  51. Pereira, Carlos F.; Piccolo, Francesco M.; Tsubouchi, Tomomi; Sauer, Stephan; Ryan, Natalie K.; Bruno, Ludovica; Landeira, David; et al. "ESCs Require PRC2 to Direct the Successful Reprogramming of Differentiated Cells toward Pluripotency". Cell Stem Cell 6 6 (2010): 547-556.
    10.1016/j.stem.2010.04.013
  52. Landeira, David; Sauer, Stephan; Poot, Raymond; Dvorkina, Maria; Mazzarella, Luca; Jorgensen, Helle F.; Pereira, C. Filipe; et al. "Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators". Nature Cell Biology 12 6 (2010): 618-U214.
    10.1038/ncb2065
  53. Schnetz, M.P.; Handoko, L.; Akhtar-Zaidi, B.; Bartels, C.F.; Pereira, C.F.; Fisher, A.G.; Adams, D.J.; et al. "CHD7 targets active gene enhancer elements to modulate ES cell-specific gene expression.". PLoS genetics 6 7 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-79952538205&partnerID=MN8TOARS.
  54. Correia, Margareta P.; Cardoso, Elsa M.; Pereira, Carlos F.; Neves, Rui; Uhrberg, Markus; Arosa, Fernando A.. "Hepatocytes and IL-15: A Favorable Microenvironment for T Cell Survival and CD8(+) T Cell Differentiation". Journal of Immunology 182 10 (2009): 6149-6159.
    10.4049/jimmunol.0802470
  55. Banito, Ana; Rashid, Sheikh T.; Acosta, Juan Carlos; Li, SiDe; Pereira, Carlos F.; Geti, Imbisaat; Pinho, Sandra; et al. "Senescence impairs successful reprogramming to pluripotent stem cells". Genes & Development 23 18 (2009): 2134-2139.
    10.1101/gad.1811609
  56. Jorgensen, Helle F.; Terry, Anna; Beretta, Chiara; Pereira, C. Filipe; Leleu, Marion; Chen, Zhou-Feng; Kelly, Claire; Merkenschlager, Matthias; Fisher, Amanda G.. "REST selectively represses a subset of RE1-containing neuronal genes in mouse embryonic stem cells". Development 136 5 (2009): 715-721.
    10.1242/dev.028548
  57. Savarese, Fabio; Davila, Amparo; Nechanitzky, Robert; De La Rosa-Velazquez, Inti; Pereira, Carlos F.; Engelke, Rudolf; Takahashi, Keiko; et al. "Satb1 and Satb2 regulate embryonic stem cell differentiation and Nanog expression". Genes & Development 23 22 (2009): 2625-2638.
    10.1101/gad.1815709
  58. Pereira, C.F.; Fisher, A.G.. "Heterokaryon-based reprogramming for pluripotency". Current Protocols in Stem Cell Biology SUPPL. 9 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-65149087887&partnerID=MN8TOARS.
    10.1002/9780470151808.sc04b01s9
  59. Pereira, Carlos F.; Terranova, Remi; Ryan, Natalie K.; Santos, Joana; Morris, Kelly J.; Cui, Wei; Merkenschlager, Matthias; Fisher, Amanda G.. "Heterokaryon-Based Reprogramming of Human B Lymphocytes for Pluripotency Requires Oct4 but Not Sox2". Plos Genetics 4 9 (2008):
    10.1371/journal.pgen.1000170
  60. Nunes, R.J.; Castro, M.A.A.; Gonçalves, C.M.; Bamberger, M.; Pereira, C.F.; Bismuth, G.; Carmo, A.M.. "Protein interactions between CD2 and Lck are required for the lipid raft distribution of CD2". Journal of Immunology 180 2 (2008): 988-997. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000252290000036&KeyUID=WOS:000252290000036.
    10.4049/jimmunol.180.2.988
  61. Terranova, R.; Pereira, C. F.; Du Roure, C.; Merkenschlager, M.; Fisher, A. G.. "Acquisition and extinction of gene expression programs are separable events in heterokaryon reprogramming". Journal of Cell Science 119 10 (2006): 2065-2072.
    10.1242/jcs.02945
  62. Cabrita, M.; Pereira, C. F.; Rodrigues, P.; Cardoso, E. M.; Arosa, F. A.. "Altered expression of CD1d molecules and lipid accumulation in the human hepatoma cell line HepG2 after iron loading". Febs Journal 272 1 (2005): 152-165.
    10.1111/j.1432-1033.2004.04387.x
  63. Arosa, F. A.; Pereira, C. F.; Fonseca, A. M.. "Red blood cells as modulators of T cell growth and survival". Current Pharmaceutical Design 10 2 (2004): 191-201.
    10.2174/1381612043453432
  64. Fonseca, A.M.; Pereira, C.F.; Porto, G.; Arosa, F.A.. "Red blood cells upregulate cytoprotective proteins and the labile iron pool in dividing human T cells despite a reduction in oxidative stress". Free Radical Biology and Medicine 35 11 (2003): 1404-1416. http://www.scopus.com/inward/record.url?eid=2-s2.0-0344875071&partnerID=MN8TOARS.
    10.1016/j.freeradbiomed.2003.08.011
  65. Fonseca, A. M.; Pereira, C. F.; Porto, G.; Arosa, F. A.; Fonseca, A.M.; Pereira, C.F.; Arosa, F.A.. "Red blood cells promote survival and cell cycle progression of human peripheral blood T cells independently of CD58/LFA-3 and heme compounds". Cellular Immunology 224 1 (2003): 17-28. http://www.scopus.com/inward/record.url?eid=2-s2.0-0142169441&partnerID=MN8TOARS.
    10.1016/s0008-8749(03)00170-9
Capítulo de livro
  1. Pereira, Carlos-Filipe; Lemischka, Ihor R.; Moore, Kateri. "Reprogramming cell fates: insights from combinatorial approaches". editado por Kanz, L.; Fibbe, W. E.; Lengerke, C.; Dick, J. E., 7-17. 2012.
    10.1111/j.1749-6632.2012.06508.x
Revisão de livro
  1. Kateri Moore; Pereira C.F.. "F1000Prime Recommendation". (2014): http://f1000.com/prime/718204823#eval793489162.
    10.3410/f.718204823.793489162
Tese / Dissertação
  1. Pereira, Carlos-Filipe. "Generating Dendritic Cells by Direct Cell Reprogramming". Doutoramento, Lunds universitet Institutionen för laboratoriemedicin Lund, 2021.
  2. Pereira, Carlos-Filipe. "Elucidating mechanisms of antigen presentation in tumor cells". Mestrado, Universität Wien, 2021.
  3. Pereira, Carlos-Filipe. "MIRNA-DIRECTED DENDRITIC CELL REPROGRAMMING". Mestrado, Lund Universitet Institutionen för laboratoriemedicin Malmö, 2020.
  4. Pereira, Carlos-Filipe. "Inducing plasmacytoid dendritic like-cells with cell reprogramming". Mestrado, Lund Universitet Institutionen för laboratoriemedicin Malmö, 2020.
  5. Pereira, Carlos-Filipe. "Reprogramming lung carcinoma cells into antigen presenting cells". Mestrado, Lunds universitet Institutionen för laboratoriemedicin Lund, 2020.
  6. Pereira, Carlos-Filipe. "Understanding the genetic program of conventional dendritic cells type 2 with direct reprogramming". Mestrado, Centro de Inovação em Biomedicina e Biotecnologia (CIBB), 2019.
  7. Pereira, Carlos-Filipe. "Elucidating Gata2 Transcription Factor Role during DNA Replication and Epigenetic Inheritance". Mestrado, Centro de Inovação em Biomedicina e Biotecnologia (CIBB), 2019.
  8. Pereira, Carlos-Filipe. "Dissecting mechanisms underlying dendritic cell epigenetic reprogramming". Mestrado, Lunds Universitet, 2019.
  9. Pereira, Carlos-Filipe. "Elucidating blood origin: from reprogramming to ontogeny". Doutoramento, Universidade de Coimbra, 2018.
  10. Santos, Ana Raquel Pereira. "The role of LSD1/CoREST during hemogenic reprogramming.". Mestrado, 2018. http://hdl.handle.net/10316/82432.
  11. Caiado, Inês Maria Nascimento. "Inducing Antigen Presentation in Tumor cells by Direct Reprogramming". Mestrado, 2018. http://hdl.handle.net/10316/86201.
  12. Alves, Rita Alexandra Silvério. "Designing Transcription Factors for Efficient Hematopoietic Reprogramming". Mestrado, 2017. http://hdl.handle.net/10316/83092.
  13. Pereira, Carlos-Filipe. "Generating a Personalized Immunotherapy by Reprogramming Fibroblasts to Regulatory T cells". Mestrado, Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, 2017.
  14. Rosa, Fábio Alexandre Fiúza. "Direct Reprogramming of Fibroblasts to Dendritic Cells for Immunotherapy". Mestrado, 2016. http://hdl.handle.net/10316/33773.
  15. Pereira, Carlos-Filipe. "Epigenetic events underlying somatic cell reprogramming.". Doutoramento, Imperial College Faculty of Medicine - Hammersmith Campus, 2009.

Propriedade Intelectual

Patente
  1. Pereira, Carlos-Filipe. 2021. "Compositions for reprogramming into dendritic cells type 2 competent for antigen presentation, methods and uses thereof.".
  2. Pereira, Carlos-Filipe. 2020. "Compositions for reprogramming cells into dendritic cells or antigen presenting cells, methods and uses thereof. In-license to start-up company Asgard Therapeutics AB.".
    Pendente
  3. Pereira, Carlos-Filipe. 2015. "Methods for Programming Differentiated Cells Into Hematopoietic Stem Cells".
  4. Pereira, Carlos-Filipe. 2015. "Method for programming differentiated cells into hematopoietic stem cells. Option agreement granted to Summer Road, NYC, USA, 2017.". Estados Unidos.
    Concedida/Emitida
Pedido provisório de patente
  1. 2023. "RNA-based strategies for dendritic cell reprogramming and uses thereof.".
    Protegido
  2. 2022. "Generation of T-cells by direct reprogramming from fibroblasts and MSC.".
    Protegido
  3. 2020. "Compositions, constructs and vectors for cell reprogramming (NK cell reprogramming).".
    Protegido
  4. 2019. "Compositions for reprogramming cells into plasmacytoid dendritic cells or interferon producing cells, methods and uses thereof.".
    Protegido

Outros

Empresa spin-off
  1. 2018. Asgard Therapeutics. Cell Reprogramming and Cancer Immunotherapy. www.asgardthx.com.
  2. 2017. BRT Blood Reprogramming Technologies. Cell Reprogramming and Blood Regeneration. www.bloodrt.com.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2024/03/15 Empowering Cancer Immunotherapy with Cellular Reprogramming. Invited seminar at City University of Hong Kong
(Hong Kong)
2024/03/14 Empowering Cancer Immunotherapy with Cellular Reprogramming Invited seminar at The Chinese University of Hong Kong
(Hong Kong)
2024/03/13 Empowering Cancer Immunotherapy with Cellular Reprogramming Invited seminar at Hong Kong University
(Hong Kong)
2024/03/11 A cancer immunotherapy modality based on dendritic cell reprogramming in vivo. Invited seminar at Guangzhou laboratory
(China)
2023/12/14 Empowering Immunotherapy with Cellular Reprogramming Alicante Winter Immunology Symposium in Health
2023/11/28 Empowering Immunotherapy with Cellular Reprogramming ISSCR Cell Fate Programming Webinar
2023/10/30 Reprogramming of Cancer Cells to Antigen-presenting Cells for Immunotherapy Takara Webinar
2023/10/23 Empowering Immunotherapy with Cellular Reprogramming NYSCF annual meeting
Raeka Aiyar (New York, Estados Unidos)
2023/10/11 Empowering Immunotherapy with Cellular Reprogramming CSHL Cell Fate Conversions conference
Thomas Graf (New York, Estados Unidos)
2023/10/05 Harnessing Cellular Reprogramming for Cancer Immunotherapy and Beyond Novo Nordisk Foundation Science Lecture: Distinguished Innovators
Novo Nordisk Foundation (Copenhagen, Dinamarca)
2023/09/29 Empowering Immunotherapy with Cellular Reprogramming Seminar at Instituto superior técnico
Simão Rocha (Lisbon, Portugal)
2023/06/01 Harnessing Direct Cellular Reprogramming for Cancer Immunotherapy Seminar at Karolinska Institute
(Stockholm, Suécia)
2023/05/09 Harnessing Cellular Reprogramming for Cancer Immunotherapy Linköping University cancer seminar series
2023/04/24 Cellular Reprogramming of Cancer Cells to Antigen-Presenting Cells Spring Brain Conference
(Sedona, Arizona, Estados Unidos)
2023/04/17 Restoring Tumor Immunogenicity with Dendritic Cell Reprogramming Lund Stem Cell Centre 25th Anniversary Conference
Lund Stem Cell Centre (Lund, Suécia)
2023/03/17 Cell Fate Reprogramming in Hematopoiesis and Immunity Departmental seminar
Carolina Guibentif (Gothenburg, Suécia)
2023/03/06 Cell Fate Reprogramming in Hematopoiesis and Immunity. Departmental seminar University of Texas Health Science Center
Dung-Fang Lee (Houston, Estados Unidos)
2023/03/01 Since 2015 my research group has delivered 122 communications (67 oral communications and 55 posters).
2023/02/04 Restoring Tumor Immunogenicity with Dendritic Cell Reprogramming. Darwin Regional Conference
STEM Community IUB (Virtual)
2022/12/02 Cell Fate Reprogramming in Hematopoiesis and Immunity. BSRT symposium 2022
(Berlin, Alemanha)
2022/10/20 Cell Fate Reprogramming in Hematopoiesis and Immunity Departmental seminar Columbia University
Jianlong Wang (New York, Estados Unidos)
2022/10/20 Cell Fate Reprogramming in Hematopoiesis and Immunity Departmental seminar at the Icahn School of Medicine at Mount Sinai
Eirini Papapetrou (New York, Estados Unidos)
2022/06/30 Harnessing direct cell reprogramming for cancer immunotherapy Journal Club at Bluepharma
Bluepharma (Coimbra, Portugal)
2022/06/15 Development of a Cancer Immunotherapy Based on Dendritic Cell Reprogramming ISSCR Annual meeting
(San Francisco, Estados Unidos)
2022/05/27 Harnessing Direct Cell Reprogramming for Cancer Immunotherapy Institute seminar at i3S
Pedro Resende (Porto, Portugal)
2022/05/03 Spinning-off the Development of a Cancer Immunotherapy Based on Cellular Reprogramming NMMP meeting
Wallenberg Centers for Molecular Medicine (Ystad, Suécia)
2021/11/24 Development of a Cancer Gene Therapy Based on Cellular Reprogramming Medicon Valley Alliance R&D Network meeting; Emerging Cell and Gene Therapies
Medicon Valley Alliance (Lund, Suécia)
2021/11/09 Combining Cell Fate Reprogramming & Immunotherapy: A Revolutionary Approach for Cancer Treatment. Princeton Propellers Zoom event
Princeton Propellers (Princeton, Estados Unidos)
2021/10/05 Harnessing Direct Cell Reprogramming for Cancer Immunotherapy Stem Cells @ Lunch
Kings College (London, Reino Unido)
2021/06/25 Harnessing Direct Cell Reprogramming for Cancer Immunotherapy Departmental seminar Pasteur institute
Ana Cumano (Paris, França)
2021/05/27 Harnessing Direct Cell Reprogramming for Cancer Immunotherapy Virtual mini symposium on immunity
Kenichi Miharada (Kumamoto, Japão)
2021/03/01 Cellular Reprogramming of Cancer Cells to Antigen-presenting Cells European Respiratory Society annual meeting
European Respiratory Society
2020/10/26 Harnessing Direct Cell Reprogramming for Cancer Immunotherapy Institute of Molecular Medicine, Faculty of Medicine of the University of Lisbon, Lisbon, Portugal.
Invited by Sergio Almeida. (lisbon, Portugal)
2020/09/20 Cell Reprogramming in Hematopoiesis and Immunity Institute seminar at St. Anna Children's hospital
Kaan Boztug (Vienna, Áustria)
2020/06/23 In Vitro Generation of HSCs and Beyond 25th European Hematology Association (EHA) Congress, Virtual.
Invited by Kimmo Porkka.
2020/05/01 Generating human type 1 dendritic cells by direct cell reprogramming International Society for Stem Cell Research 2020
International Society for Stem Cell Research
2019/06/01 Reprogramming a Career in Science Future Faculty career paths and independence seminar.
Lund University, Lund, Sweden.
2019/05/01 Cell Reprogramming in Hematopoiesis and Immunity Principles of pluripotent stem cells underlying plant vitality symposium.
Tohoku University, Japan. Invited by Tomomi Tsubouchi. (Tohoku, Japão)
2019 Harnessing Dendritic Cell Reprogramming for Cancer Immunotherapy Biotech Research & Innovation Centre (BRIC) University of Copenhagen
BRIC external seminar series (Copenhagen, Dinamarca)
2019 Reprogramming cellular identity for regenerative medicine and cancer immunotherapy Umeå University
Cancer series seminar Umeå (Umeå, Suécia)
2019 Harnessing direct cell reprogramming for cancer immunotherapy Autolus UK
Autolus external seminar UK (London, Reino Unido)
2018 Elucidating Hematopoietic Reprogramming with Single Cell Resolution. Danish single cell symposium.
Novo Nordisk Foundation, Hellerup, Denmark. Invited by Konstantin Khodosevich. (Copenhagen, Dinamarca)
2018 New challenges of genetics - cellular reprogramming technologies TAIEX Regional Workshop on Biomedical Engineering – Genetics.
European Commission Expert Mission. (Sarajevo, Bósnia-Herzegovina)
2018 Cellular Reprogramming in Hematopoiesis and Immunity CIMUS external seminar series.
CIMUS, University of Santiago de Compostela, Santiago de Compostela, Spain. Invited by Miguel Fidalgo. (Santiago de Compostela, Espanha)
2018 Developing a cancer immunotherapy based on direct dendritic cell reprogramming Lund Stem Cell Center, StemTherapy LU Innovation award pitch.
lund Stem Cell Center (Båstad, Suécia)
2018 Programming Definitive Hematopoiesis and Immunity Symposium in Memory and Celebration of Ihor R. Lemischka,
Mount Sinai School of Medicine. Invited by Marek Mlodzik & Saghi Ghaffari. (New York City, Estados Unidos)
2018 Cellular Reprogramming in Hematopoiesis and Immunity Centre for genomics and oncological research, University of Granada, Granada, Spain.
Centre for genomics and oncological research external seminar series. Invited by David Landeira. (Granada, Espanha)
2018 Cellular Reprogramming in Hematopoiesis and Immunity Department of Laboratory Medicine, Lund University, Lund, Sweden.
Department of Laboratory Medicine seminar series. (Lund, Suécia)
2018 Cellular Reprogramming in Hematopoiesis and Immunity Department of Pathology and Immunology, School of Medicine, University of Geneva, Geneva, Switzerland.
Department of Pathology and Immunology external seminar series. Invited by Julien Bertrand. (Geneva, Suiça)
2018 Cellular Reprogramming in Hematopoiesis and Immunity International PhD Course in Molecular Medicine. Developmental Biology: Mechanisms, Models and Applications. Milan, Italy. 50 students.
San Raffaelle Institute (Milan, Itália)
2017 Cellular Reprogramming in Hematopoiesis and Immunity Department of Fundamental Oncology, University of Lausanne, Ludwig Center for Cancer Research, Lausanne, Switzerland.
Department of Fundamental Oncology external seminar series. Invited by Ping-Chih Ho. (Lausanne, Suiça)
2017 Reprogramming a career in Science Lund Stem Cell Center Annual Retreat.
Lund Stem Cell Center (Ystad, Suécia)
2017 Programming Definitive Hematopoiesis and Immunity 46th Annual Scientific Meeting International Society for Experimental Hematology ISEH.
International Society for Experimental Hematology (Frankfurt, Alemanha)
2017 (Re) Programming Haematopoiesis and Immunity XV Congress SIC - Sociedade Iberica de Citometria. CCB.
Sociedade Iberica de Citometria. (Lisbon, Portugal)
2017 Programming Hematopoiesis and Immunity Division of Molecular Medicine and Gene Therapy, University of Lund, Sweden.
Division of Molecular Medicine and Gene Therapy external seminar (lund, Suécia)
2017 (Re) Programming Hematopoiesis and Immunity III Semana da Bioengenharia. Instituto Superior Técnico, Lisbon, Portugal.
Students from Instituto Superior Técnico. (Lisbon, Portugal)
2017 (Re) Programming Hematopoiesis and Immunity III – Encontro Nacional de Estudantes de Biotecnologia, Aveiro, Portugal.
Students of Biotechnology from Aveiro. (Aveiro, Portugal)
2016 Reprogramming a career in Science 5º Fórum Anual de Graduados Portugueses no Estrangeiro (GraPE), Coimbra, Portugal.
Associação de Graduados Portugueses no Estrangeiro (GraPE) (Coimbra, Portugal)
2016 Programming Hematopoiesis and Immunity 1st Meeting on Biomedical Research @ UC, Coimbra, Portugal.
Coimbra University (Coimbra, Portugal)
2016 Programming Definitive Hematopoiesis and Immunity MRC Centre for Regenerative Medicine, University of Edinburgh, UK.
MRC Centre for Regenerative Medicine. Invited by Keisuke Kaji. (Edinburgh, Reino Unido)
2016 Programming Definitive Hematopoiesis Centre of Regenerative Medicine (CRMB), Barcelona, Spain.
Centre of Regenerative Medicine (CRMB) external seminar series. Invited by Alessandra Giorgetti. (Barcelona, Espanha)
2016 Programming Definitive Hematopoiesis Erasmus University Medical Center, Rotterdam, The Netherlands.
Erasmus University Medical Center external seminar. Invited by Frank Grosveld. (Rotterdam, Países Baixos)
2016 Definir a origem das células estaminais do sangue com a reprogramação celular II Workshop of Stem Cells, Hospitals of the University of Coimbra, Portugal.
Hospitals of the University of Coimbra. Invited by Artur Paiva. (Coimbra, Portugal)
2016 Institute for Molecular Medicine, PhD Program Meeting, Lisbon, Portugal. Institute for Molecular Medicine, PhD Program Meeting.
PhD Program Meeting at IMM. (Lisbon, Portugal)
2016 Reprogramming at the single cell resolution Single Cell Analysis and High-throughput Biology, Cantanhede, Portugal.
UC-Biotech single cell analysis workshop (Cantanhede, Portugal)
2016 Programming definitive hematopoiesis ICVS epigenetics course, Institute for Health and Life Sciences, Braga, Portugal.
ICVS (Braga, Portugal)
2016 Defining hematopoietic stem cell origin with direct cell reprogramming ICVS flow cytometry course, Institute for Health and Life Sciences, Braga.
ICVS (Braga, Portugal)
2015 Programming definitive hematopoiesis Cancer Research UK Manchester Institute, Manchester, UK.
Cancer Research UK external seminar. Invited by Georges Lacaud. (Manchester, Reino Unido)
2015 Programming definitive hematopoiesis CNC.IBILI Seminar, Coimbra, Portugal.
CNC.IBILI (Coimbra, Portugal)
2015 Programming Definitive Hematopoiesis Plenary Lecture. Sociedade Portuguesa Células Estaminais Anual Meeting, Oeiras, Portugal.
Sociedade Portuguesa Células Estaminais (Oeiras, Portugal)
2015 Induction of hemogenesis in fibroblasts CNC.IBILI Seminar, Cantanhede, Portugal.
CNC.IBILI (Cantanhede, Portugal)
2015 Induction of Hemogeneis in fibroblasts Charles H. Revson Foundation, New York, USA.
Charles H. Revson Foundation (new york, Estados Unidos)
2015 Programming definitive hematopoiesis Next Gen Stem Cell Meeting.
Next Gen Stem Cell Meeting. (Saratoga, Estados Unidos)
2015 Programming and Reprogramming Cell Fate Royan Stem Cell Summer School, Cellular Reprogramming and Hematopoiesis, Royan Institute.
Royan Institute. (Tehran, Irão)
2014 Programming Definitive Hematopoiesis CNC.IBILI Annual Meeting.
CNC.IBILI (Coimbra, Portugal)
2014 Programming definitive hematopoiesis Weatherall Institute of Molecular Medicine, Oxford, UK. Invited by Marella de Brujin.
Weatherall Institute of Molecular Medicine. Invited by Marella de Brujin. (Oxford, Reino Unido)
2012 Induction of hemogenesis from fibroblasts Biocant Park, Cantanhede, Portugal.
Biocant Park external seminar series. (Cantanhede, Portugal)
2012 Programming hematopoietic stem cell generation with defined factors Gordon Conference: Reprogramming Cell Fate.
Gordon Conference: Reprogramming Cell Fate. (Galveston, Estados Unidos)
2011 Heterokaryon-based reprogramming to pluripotency 7th Royan International Congress, Tehran, Iran.
Royan institute. (Tehran, Irão)
2009 ESCs require PRC2 to direct the successful reprogramming of differentiated cells toward pluripotency. HBGS symposium in Epigenetics.
HBGS symposium in Epigenetics. (Helsinki, Finlândia)
2008 Heterokaryn-based reprogramming to pluripotency Cancer Research UK Stem Cell Meeting, London, UK.
Cancer Research UK (London, Reino Unido)
2006 Heterokaryn-based reprogramming to pluripotency Joint UK-CIRM Stem Cell Conference, Broadway, UK.
Joint UK-CIRM Stem Cell Conference. (Broadway, Reino Unido)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2024 - 2027 Transcriptional models underlying direct dendritic cell reprogramming and lineage commitment
Orientador
Lunds Universitet, Suécia
2023 - 2026 Direct Reprogramming of fibroblasts into NK cells
Orientador
Lunds Universitet, Suécia
2023 - 2026 Multiplexed COHORT-seq to Establish B-cell Reprogramming for Cancer Immunity
Orientador
2022 - 2025 Harnessing Dendritic Cell Reprogramming to Elucidate Mechanisms of Tumor Immunity
Orientador
Lunds Universitet, Suécia
2021/01/01 - 2024/12/31 Elucidating dendritic cell diversity with cellular reprogramming
Orientador de Luís Oliveira
Universidade de Coimbra, Portugal
2021/01/01 - 2024/12/31 Harnessing RNA programming for cancer immunotherapy
Orientador de Nejc Arh
Lunds Universitet, Suécia
2020/01/01 - 2023/12/31 Inducing lymphoid cells with cellular reprogramming
Orientador de Inês Caiado
Universidade de Coimbra, Portugal
2018/06/01 - 2022/05/31 Mitotic bookmarking in hematopoietic stem cells
Orientador de Rita Alves
Universidade de Coimbra, Portugal

Lunds Universitet, Suécia
2018/01/01 - 2021/12/31 Inducing antigen presentation in tumor cells with direct cell reprogramming
Orientador de Alexandra Gabriela Ferreira
Universidade de Coimbra, Portugal

Lunds Universitet, Suécia
2018/01/01 - 2021/06/10 Generating Dendritic Cells by Direct Cell Reprogramming
Orientador de Fábio Rosa
Universidade de Coimbra, Portugal

Lunds Universitet, Suécia
2020/01/01 - 2021/02/25 Elucidating mechanisms of antigen presentation in tumor cells
Orientador de Ervin Ascic
Universität Wien, Áustria
2019/09/01 - 2020/07/31 Reprogramming lung carcinoma cells into antigen presenting cells
Orientador de Ariane Eceiza Tenreiro
Lunds Universitet, Suécia
2019/09/01 - 2020/07/31 MIRNA-DIRECTED DENDRITIC CELL REPROGRAMMING
Orientador de Nejc Arh
Lunds Universitet, Suécia
2019/09/01 - 2020/07/31 Inducing plasmacytoid dendritic like-cells with cell reprogramming
Orientador de Jennyfer Pastor Gómez
Lunds Universitet, Suécia
2018/09/01 - 2019/07/31 Dissecting mechanisms underlying dendritic cell epigenetic reprogramming
Orientador de Svandís Þóra Sæmundsdóttir
Lunds Universitet, Suécia
2019 - 2019 Understanding the Genetic Program of Conventional Dendritic Cells Type 2 with Direct Cell Reprogramming
Orientador de Luís Filipe Henriques Oliveira
 Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019 - 2019 Elucidating Gata2 transcription factor role during DNA replication and epigenetic inheritance
Orientador de Catarina Milheiro Soares da Silva
 Bioquímica (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018 - 2018 Inducing Antigen Presentation in Tumor cells by Direct Reprogramming
Orientador de Inês Maria Nascimento Caiado
 Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018 - 2018 The role of LSD1/CoREST during hemogenic reprogramming.
Orientador de Ana Raquel Pereira Santos
 Investigação Biomédica (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2017 - 2017 Designing Transcription Factors for Efficient Hematopoietic Reprogramming
Orientador de Rita Alexandra Silvério Alves
 Bioquímica (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2017 - 2017 Generating a Personalized Immunotherapy by Reprogramming Fibroblasts to Regulatory T Cells
Orientador de Alexandra Gabriela Barros Ferreira
 Genética Molecular (Mestrado)
Universidade do Minho, Portugal
2016 - 2016 Elucidating Blood Origin: From Reprogramming to Ontogeny
Orientador de Andreia Marques Gomes
 Biologia Experimental e Biomedicina (Doutoramento)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2023 - 2023 Organizer of "Stem Cell Stars" monthly seminar series, aiming to bring leaders in stem cell research and regenerative medicine to Lund University. (2023 - 2023) Lunds Universitet, Suécia
2023 - 2023 ISSCR program committee Hamburg 2024 - New Technologies (2023 - 2023)
2022 - 2022 National Molecular Medicine Fellows Program (2022 - 2022) Lunds Universitet, Suécia
2021 - 2021 WCMM Research school retreat. 2-day event with workshops on ethics and writing, public outreach presentation with videos prepared by the trainees and announcement of the winner of the grant writing competition. ~20 participants. (2021 - 2021)
Oficina (workshop)
 Lunds Universitet, Suécia
2021 - 2021 Young Investigator “First author” symposium: Advances in stem cell research organising committee (2021 - 2021) Lunds Universitet, Suécia
2018 - 2020 2020 Lund stem cell centre first author symposium, Lund , Sweden. 2018 Lund stem cell centre retreat organising committee, Lund, Sweden. (2018 - 2020)
Simpósio
 Lunds Universitet, Suécia
2003 - 2019 2019 Immunology day, part of the international immunology day, Cantanhede, Portugal. 2017 Immunology day, part of the international immunology day, Cantanhede, Portugal. 2016 Immunology day, part of the international immunology day, Cantanhede, Portugal. 2015 Flow Cytometry Workshop (theoretical and practical), Cantanhede, Portugal. 2013 International Conference on Stem Cells for Drug Screening, Cantanhede, Portugal. 2003 GABBA PhD program Annual Symposium: Nanotechnology and Medicine, Porto, Portugal. (2003 - 2019)
Simpósio (Coorganizador)
 Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2023 2023 Sandhya Malla, Department of Molecular Biology, Wallenberg Centre for Molecular Medicine, Umeå University, Sweden Sandhya Malla (Doutoramento)
2021 2021 João Calmeiro, University of Coimbra, Portugal João Calmeiro (Doutoramento)
2017 2018 Alban Johansson, Molecular Biology Lund University, Lund, Sweden 2017 Mariana Alves, University of Coimbra, Portugal.
Arguente principal
 Opponent for 2 master student thesis (Mestrado)
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2015 2018 Sílvia Arroz Madeira, University of Lisbon, Lisbon, Portugal. 2017 Inês Sofia Alvarez Martins, Faculty of Medicine University of Lisbon, Portugal. 2017 Ana Francisca Silva de Lima, Faculty of Sciences and Technology, Nova University of Lisbon, Portugal. 2015 Magdalena Bronislawa Florkowska, University of Manchester, UK. PhD opponent for 4 students (Doutoramento)
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2021/03/01 - Atual Editor-in-Chief Cellular Reprogramming Mary Ann Liebert
2017 - Atual Editorial Board Member, Cancer reports and reviews.
2013 - Atual Editorial Board Member, International Journal of Stem Cell Research and Transplantation.

Consultoria / Parecer

Descrição da atividade Instituição / Organização
2023/01/01 - Atual Advisor to Retro Biosciences a company that aims to extend human healthy lifespan with cellular reprogramming.
2019 - 2021/12/31 Consultant for the company Autolus Ltd, UK. Lunds Universitet, Suécia

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2021/02/18 - Atual 2021- Coordinator of the stem cells and regenerative medicine 5-week course at the Biomedicine Master's Program. Lund University. 25 students. Stem cells and Regenerative Medicine (Master) Lunds universitet Lunds stamcellscentrum, Suécia
2018 - 2020 2018-2020 Lecturer at WCMM Regenerative Medicine Research School, Lund, Sweden. 30 students. 2018 Lecturer at the International PhD Course in Molecular Medicine: Developmental Biology: Mechanisms, Models and Applications, San Raffaele Telethon Institute for Gene Therapy, Milan, Italy. 60 students. 2018 Lecturer at the symposium on single cell technologies in stem cell research, Lund University, Sweden. 30 students. (Doktor (PhD)) Lunds Universitet, Suécia
2015 - 2017 2015 - 2017 Lecturer at the MIT-Portugal doctoral program, Cellular Reprogramming, ITQB, Nova University of Lisbon, Portugal. 12 students. 2015 ¿ 2017 Lecturer at the PDBEB doctoral program, Cellular Reprogramming, University of Coimbra, Portugal. 12 students. 2016 Lecturer at the doctoral program in metabolism, Cellular Reprogramming and Hematopoiesis, Faculty of Medicine, University of Porto, Portugal. 6 students. 2016 Lecturer at the Cellular & Molecular Biology Master Program, Flow Cytometry, University of Coimbra, Portugal. 60 students. (Doutoramento) Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal

Entrevista (jornal / revista)

Descrição da atividade Jornal / Forum
2020 Public engagement: Participation in the various media including interviews for national TV, radio and newspapers. Lecture to high school students and teachers, Instituto de Educação e Cidadania, Mamarrosa, Portugal. Contribution to ART LAB, Science Xplore. A six-day summer science and art workshop for high school students, Viseu, Portugal. European Researchers' Night: exploring science whilst having fun, Museum of Science, Coimbra, Portugal. Contribution to “Saberás tu” journal, Ciência Viva Program, Lisbon, Portugal.
2005 Public engagemnet: CORDIS documentary on epigenetics “The hidden life of our genes”, London, UK. Royal Albert Hall Exhibition, “Scopic”, inter-disciplinary educational initiative for school students, engaging them in both the sciences and the arts, London, UK. “Genes talking” live sequencing lab Institute of Contemporary Arts, London, UK.

Membro de associação

Nome da associação Tipo de participação
2010/01/01 - Atual Membership of scientific societies: 2016 – Associated Member, Portuguese Society for Developmental Biology. 2015 – Associated Member, Portuguese Immunology Society. 2015 – Associated Member, Portuguese Society for Stem Cells and Cell Therapies. 2012 – 2015 Individual Member, New York Academy of Sciences. 2011 – Associated Member, International Society for Experimental Hematology. 2010 – Associated Member, International Society for Stem Cell Research.
2016 - 2020 Membership of scientific societies: 2020 – Active Member, ASH American Society of Hematology. 2020 – Active Member, EMDS European Macrophage & Dendritic Cell Society. 2020 – Active Member, SITC Society for Immunotherapy of Cancer. 2017 – Active Member, EHA European Hematology Association. 2017 – Active Member, AACR American Association for Cancer Research. 2015 – 2017 Governing Board, Portuguese Society for Stem Cells and Cell Therapies. 2016 – Academic Member, European Society of Gene and Cell Therapy.
2003 - 2020 Associate Faculty Member, Faculty of 1000. Associate Faculty Member, Faculty of 1000.

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2018 - 2020 2018-2021 WCMM Regenerative Medicine Research School steering board, Lund University, Sweden.
Outro
 Lunds Universitet, Suécia
2015 - 2020 PhD Thesis Committee Member: Sara Norbalt, Sandra Capellera Garcia and Trine Kristiansen, Lund University, Sweden; João Mendes, University of Coimbra, Portugal.
Membro
 Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2015 - 2020 Reviewer for Nature, Science Immunology, Cell Stem Cell, Cell Reports, Development, Stem Cell Reports, Stem Cells and Development, Nature Communications and others. Total of 39 verified reviews at Publons (https://bit.ly/2UbAich). Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2016 - 2019 2019 Grant reviewer for the Medical Research Council, UK. 2018 Grant reviewer for the French National Research Agency, ANR, France. 2018 Reviewer for future faculty, postdoctoral application for the Swedish research council. 2016 Grant reviewer for FCT, cooperation grant between Portugal and India, FCT, Portugal. Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal

Tutoria

Tópico Nome do aluno
2015 - 2030 Cell Reprogramming in Hematopoiesis and Immunity Laboratory: Current main supervisor of 5 postdocs, 6 PhD students, 4 MSC students, 1 intern and 1 technician Current supervisor of a team with 17 members
2015 - 2030 Research team and funding: Total funding raised by my research group since 2015 in grants, fellowships , innovation and awards: 11 million euros. Current supervisor of a team with 17 members
Distinções

Prémio

2023 Eric K. Fernström Prize for Young Researchers
Erik och Edith Fernströms Stiftelse för Medicinsk Forskning, Suécia
2022 Novo Nordisk Distinguished Innovator Award for science entrepreneurs.
Novo Nordisk Fonden, Dinamarca
2020 Mount Sinai School of Medicine KiiLN entrepreneurship award.
Icahn School of Medicine at Mount Sinai, Estados Unidos
2019 Medal of merit for outstanding achievements in cell reprogramming
Municipio de Valença, Portugal
2018 StemTherapy LU Innovation award.
Lunds Universitet, Suécia

Outra distinção

2023 ERC Proof of Concept grant
European Commission, Bélgica
2022 CEEC Auxiliary researcher 6-year Individual career award
Fundação para a Ciência e a Tecnologia, Portugal
2021 Swedish Research Council (VR) Consolidator Grant
Vetenskapsradet, Suécia
2020 ERC Consolidator Grant
European Commission, Bélgica
2017 FCT Investigator Program Award. 5-year starting grant. Final classification of 8,6/9,0 (ranked #1 out of 102 applicants evaluated by the Biological and Animal Sciences international panel).
2017 Wallenberg Fellowship Molecular Medicine at Lund University, Lund, Sweden. 4- year tenure-track appointment with starting package.
Wallenberg Centre for Molecular Medicine , Suécia
2016 Innocentive Challenge 9933820 by seeker Boehringer Ingelheim. Second Place Award selected from 198 international solvers. Novel Treatment Approaches to Stop the Allergic March towards Asthma.
2015 Marie Curie International Incoming Fellowship, 2015-2017.
2014 Icahn School of Medicine at Mount Sinai post-doctoral travel award 2014
2014 ISEH travel grant award 2014, Montreal, Canada.
2013 Charles H. Revson senior fellowship in Biomedical Science.
2012 Icahn School of Medicine at Mount Sinai post-doctoral travel award 2012.
2010 EMBO Long-term postdoctoral fellowship.
2003 Doctoral fellowship from the Foundation for Science and Technology.
1998 University of Helsinki travel award.
1995 Rotary Club merit award, Portugal, 1995.