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Dr. Carvalho, PI at the Center for Neuroscience and Cell Biology (CNC), University of Coimbra (UC). She studies cellular and molecular mechanisms underlying diabetes, obesity and related complications. She has discovered that low insulin receptor substrate-1 protein levels in fat are predictors of pre-diabetes. She investigates insulin resistance and metabolic dysfunction in adipocytes and how immune cells infiltrate the adipose tissue to cause local tissue inflammation. She is interested in the effect of functional foods in combating insulin resistance and inflammation. Moreover, she has studied wound healing and tissue regeneration in diabetes, with the goal of enhancing early diagnosis of subjects at risk for chronic complications. For instance, she is assessing the role of microRNAs and antimicrobial peptides wound healing and infection. More recently, she was awarded several projects to do work on NCDs, particularly diabetes, in Guinea-Bissau, West Africa. One funded by the European Foundation of the study of Diabetes, and others, funded by the Portuguese Cooperation, Camoes Institute. She is evaluating the prevalence of type 2 and type 1 diabetes as well as gestational diabetes, in Guinea-Bissau. She is very interested in studying the impact of mobility and migration on NCDs, particularly diabetes. In addition, a good portion of these projects is dedicated to capacitating and implementing health literacy locally in Guinea-Bissau. Dr. Carvalho and her team are advocates of Health Literacy and Implementation science for the public. She has published ˜170 scientific publications (articles and and abstracts) (h-index=41; >4000 citations; scopus). She has mentored: Post-Docs (˜20); PhDs (˜12); Master (˜15), Erasmus/lab internships (˜30). She has obtained ˜30 travel fellowships from the European Foundation for the Study of Diabetes (EFSD) for young students. She has secured funding from: Europe (H2020-MSCA-ITN-2016 TREATMENT; EFSD; Diabetes UK); NIH (NIGMS-NIH P20GM109096; Pepper Older American Independence Centers; ABI); National (INFARMED; FCT; SPD; SPT), and the Institute Camoes. She is a board member: European Tissue Repair Society, senior editor: J of Endocrinology; J Mol Endocrinology, and reviewer for ˜40 journals and international funding agencies: MRC UK; Israel Sci F; FONDECYT/CONACYT; FWF Der Wissenschaftsfonds; Wellcome Trust; Diabetes UK; French ANR, etc. https://www.ncbi.nlm.nih.gov/myncbi/1N_kjxvZYzSAP/bibliography/public/ Main research lines: 1 - Insulin resistance 2 - Adipose physiology 3 - Wound healing and tissue regeneration 4 - Oxidative capacity of circulating cells and tissues 5. Health literacy and Diabetes Education
Ler resumo completo ↓
Identificação

Identificação pessoal

Nome completo
EUGÉNIA MARIA LOURENÇO DE CARVALHO

Nomes de citação

  • Carvalho, Eugenia

Identificadores de autor

Ciência ID
5E11-C215-767E
ORCID iD
0000-0001-6264-3632
Google Scholar ID
https://scholar.google.com/citations?user=AHvtGSEAAAAJ&hl=en
Scopus Author Id
https://www.scopus.com/authid/detail.uri?authorId=35083236900

Endereços de correio eletrónico

  • ecarvalh@cnc.uc.pt (Profissional)
  • eugeniamlcarvalho@gmail.com (Pessoal)

Moradas

  • Centro de Neurociências e Biologia Celular - Universidade de Coimbra. Largo Marquês de Pombal , 3004-517, Coimbra, Coimbra, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Clínica - Endocrinologia e Metabolismo
  • Ciências Médicas e da Saúde - Outras Ciências Médicas
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Tecnologias que envolvem a Manipulação de Células,Tecidos,Órgãos ou todo o Organismo
  • Ciências Médicas e da Saúde - Ciências da Saúde - Nutrição e Dietética

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Português (Idioma materno)
Sueco Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador independente (B2) Utilizador proficiente (C2)
Francês Utilizador proficiente (C1) Utilizador proficiente (C2) Utilizador independente (B1) Utilizador proficiente (C2)
Espanhol; Castelhano Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador independente (B1) Utilizador proficiente (C2)
Italiano Utilizador independente (B1) Utilizador elementar (A1) Utilizador independente (B2) Utilizador elementar (A2)
Formação
Grau Classificação
1996/06/01 - 2000/09
Concluído
 Gothenburg University (Doctor of Philosophy)
Especialização em PhD, Molecular Medicine
Göteborgs Universitet, Suécia
"Molecular mechanisms of insulin resistance with emphasis on IRS-1 and PKB/AKT. Molecular phenotyping of fat cells in young first-degree relatives of type 2 diabetic subjects. " (TESE/DISSERTAÇÃO)
1991/06/01 - 1994/06/30
Concluído
 Gothenburg University (Masterexamen)
Especialização em Biochemistry
Astra Hassle, Suécia
"A study of the active sites of Angiotensin I-Converting Enzyme, Metal and inhibitor binding. " (TESE/DISSERTAÇÃO)
1986/01/01 - 1991/01/01
Frequentou
 Marymount Manhattan College, NYC, NY, USA (Bachelor)
Especialização em Chemistry
Marymount Manhattan College, Estados Unidos
 Magna Cum Laude
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2005/09/01 - Atual Investigador principal (carreira) (Investigação) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra, Portugal
2016/02/01 - 2020/12/31 Investigador principal convidado (carreira) (Investigação) University of Arkansas for Medical Sciences, Estados Unidos
2014 - 2016/01/31 Investigador visitante (Investigação) Arkansas Childrens Hospital Research Institute, Estados Unidos
2007 - 2008 Investigador visitante (Investigação) Beth Israel Deaconess Medical Center, Estados Unidos
2001 - 2005 Pós-doutorado (Investigação) Harvard Medical School, Estados Unidos

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2005/02/01 - 2005/09/30 Professor Auxiliar (Docente Universitário) Universidade do Algarve - Campus de Gambelas, Portugal
Projetos

Bolsa

Designação Financiadores
2022 - 2027 PAS-GRAS - De-risking metabolic, environmental, and behavioral determinants of obesity in children, adolescents and young-adults
HORIZON-RIA - HORIZON-HLTH-2022-STAYHLTH-01-two-
Co-Investigador Responsável (Co-IR)
Universidade de Coimbra, Portugal
Em curso
2023 - 2025 Diabetes management, prevention, and education in Guinea-Bissau
Læge Sofus Carl Emil Friis og Hustru Olga Doris Friis' Legat
Co-Investigador Responsável (Co-IR)
Em curso
2023/03/01 - 2024/10/31 Purinergic signaling and metabolism, mycobiota control and obesity
Biocodex
Co-Investigador Responsável (Co-IR)
Universidade de Coimbra, Portugal
 Biocodex Centre de recherche
Em curso
2022/08 - 2024/10 ANGIOHEAL A new view on chronic wound healing treatment: Synergistic interplay between low-dose ionizing radiation and pre-vascularized dermal spheroids.
2022.10387.PTDC
Bolseiro de Integração na Investigação
Em curso
2022/04/01 - 2024/01/01 Diabetes diagnosis, management, prevention, and education in Guinea-Bissau
BCG-DM_BG
Em curso
2022/05/01 - 2022/09/30 Twinning Innovation - Protein enrichment of baked goods for people with special needs
IN-4-AHA-Protein
Co-Investigador Responsável (Co-IR)
Universidade de Coimbra, Portugal

Universität Hohenheim, Alemanha
Em curso
2018/11/01 - 2021/12/01 Contribution of Psychological Factors in Diabetic Foot Ulcer Healing; in Physiological Indicators of Wound Healing Prognosis and Quality of Life: A Randomized Longitudinal Effectiveness Evaluation
02/SAICT/2017 – SAICT
Outra
Fundação para a Ciência e a Tecnologia, Portugal
2018 - 2021 Antipsychotic drug induced metabolic dysfunction – in vivo studies with 2 specific drugs
H2020-MSCA-ITN-2016
Outra
2019/03 - 2020/12 CD20+ T Cells as a biomarker of inflammatory status and a promising target against cardiac rejection in heart transplanted patients
Portuguese Transplant Society
 N/A
2019/01 - 2020/12 MicroRNAs as markers of disturbed adipose tissue function and inflammation - a potential mechanism for diabetes development in obesity
COM Child Health project grant
COM Child Health project grant
Outra
University of Arkansas for Medical Sciences, Estados Unidos
 N/A
Em curso
2018/02/01 - 2020/01/01 Effects of PTP1b modulation on Wound Healing, in vitro and in vivo systems
17/0005621
Outra
Diabetes UK, Reino Unido
 Diabetes UK
Em curso
2017 - 2019/12/31 Assessment of oxidative capacity in obese children.
NIGMS-NIH P20GM109096
Outra
Em curso
2019/01/01 - 2019/12/01 Role of Regulatory T-cells in Obesity-Linked Insulin Resistance and Diabetes
COM Sturgis project grant
COM Sturgis project grant
Outra
University of Arkansas for Medical Sciences, Estados Unidos
 N/A
2017 - 2019/12 European and Portuguese funds for Human Resources
CENTRO-01-0145-FEDER-000012-N2323
Outra
Em curso
2017 - 2019/12 Establishing the presence of mitochondrial dysfunction and oxidative stress and the relationships with resting energy expenditure and fatty acid oxidation in childhood obesity.
ABI/ACHRI
Outra
Em curso
2017 - 2019/12 Microbiome of the diabetic foot ulcer in human subjects.
INFARMED
Outra
Em curso
2016 - 2018 Combination therapy synergistically accelerates diabetic wound closure.
European Research Program in Microvascular Complications of Diabetes supported by Novartis
Outra
European Foundation for the Study of Diabetes, Alemanha
Concluído
2015/06 - 2016/06 Oxidative capacity of circulating cells and muscle fibers in the elderly
NA
Orientador
University of Arkansas for Medical Sciences, Estados Unidos
Concluído

Outro

Designação Financiadores
2024/01/01 - 2025/12/31 Empoderar as comunidades para prevenção e cuidados da diabetes, uma abordagem integral e sustentável em Bissau
NA
Co-Investigador Responsável (Co-IR)
Em curso
Produções

Publicações

Artigo em conferência
  1. Pedroso, D.C.S.; Tellechea, A.; Moura, L.; Fidalgo-Carvalho, I.; Duarte, J.; Carvalho, E.; Ferreira, L.. "Improved survival, vascular differentiation and wound healing potential of stem cells co-cultured with endothelial cells in a fibrin gel". 2011.
Artigo em revista
  1. Aryane Cruz Oliveira Pinho; Pedro Barbosa; Maria João Pereira; Artur Paiva; Eugenia Carvalho; Paula Laranjeira. "The role of CD20+ T cells: Insights in human peripheral blood". Cytometry Part B: Clinical Cytometry (2024): https://doi.org/10.1002/cyto.b.22178.
    10.1002/cyto.b.22178
  2. Pedro Barbosa; Aryane Pinho; André Lázaro; Diogo Paula; José G. Tralhão; Artur Paiva; Maria J. Pereira; Eugenia Carvalho; Paula Laranjeira. "Bariatric Surgery Induces Alterations in the Immune Profile of Peripheral Blood T Cells". Biomolecules (2024): https://doi.org/10.3390/biom14020219.
    10.3390/biom14020219
  3. Aryane Cruz Oliveira Pinho; Paula Laranjeira; Eugenia Carvalho. "Role of CD20+ T cells in cancer, autoimmunity and obesity". Journal of Endocrinology (2024): https://doi.org/10.1530/JOE-23-0242.
    10.1530/JOE-23-0242
  4. Aryane Cruz Oliveira Pinho; Diana Santos; Paulo J. Oliveira; Ermelindo Carreira Leal; Eugenia Carvalho. "Real-time OXPHOS capacity analysis in wounded skin from diabetic mice: A pilot study". European Journal of Clinical Investigation (2023): https://doi.org/10.1111/eci.14128.
    10.1111/eci.14128
  5. Jessica Da Silva; Diana Santos; Margarida Vilaça; André Carvalho; Rui Carvalho; Maria de Jesus Dantas; M. Graça Pereira; Eugénia Carvalho. "Impact of Psychological Distress on Physiological Indicators of Healing Prognosis in Patients with Chronic Diabetic Foot Ulcers: A Longitudinal Study". Advances in Wound Care (2023): https://doi.org/10.1089/wound.2023.0043.
    10.1089/wound.2023.0043
  6. M. Graça Pereira; Margarida Vilaça; Diogo Braga; Ana Madureira; Jéssica Da Silva; Diana Santos; Eugénia Carvalho. "Healing profiles in patients with a chronic diabetic foot ulcer: An exploratory study with machine learning". Wound Repair and Regeneration (2023): https://doi.org/10.1111/wrr.13141.
    10.1111/wrr.13141
  7. Alphonse Laya; Honoré Wangso; Iva Fernandes; Raphaël Djakba; Joana Oliveira; Eugenia Carvalho; Wen yi Kang. "Bioactive Ingredients in Traditional Fermented Food Condiments: Emerging Products for Prevention and Treatment of Obesity and Type 2 Diabetes". Journal of Food Quality (2023): https://doi.org/10.1155/2023/5236509.
    10.1155/2023/5236509
  8. Jessica Da Silva; Ermelindo C. Leal; Eugénia Carvalho; Eduardo A. Silva. "Innovative Functional Biomaterials as Therapeutic Wound Dressings for Chronic Diabetic Foot Ulcers". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24129900.
    10.3390/ijms24129900
  9. Ermelindo C Leal; Tatiana Emanuelli; Diana Santos; João Moura; Ana Catarina RG Fonseca; Ana Burgeiro; Eugenia Carvalho. "Dysregulation of endoplasmic reticulum stress response in skin wounds in a streptozotocin-induced diabetes mouse model". Journal of Molecular Endocrinology (2023): https://doi.org/10.1530/JME-22-0122.
    10.1530/JME-22-0122
  10. Ines D. Teixeira; Eugenia Carvalho; Ermelindo C. Leal. "Green Antimicrobials as Therapeutic Agents for Diabetic Foot Ulcers". Antibiotics (2023): https://doi.org/10.3390/antibiotics12030467.
    10.3390/antibiotics12030467
  11. Pedro Barbosa; Eugenia Carvalho. "Are Dietary Sugars Potent Adipose Tissue and Immune Cell Modulators?". Diabetology (2023): https://doi.org/10.3390/diabetology4010005.
    10.3390/diabetology4010005
  12. Diana Santos; Patricia Porter-Gill; Grace Goode; Leanna Delhey; Anja Elaine Sørensen; Shannon Rose; Elisabet Børsheim; Louise Torp Dalgaard; Eugenia Carvalho. "Circulating microRNA levels differ in the early stages of insulin resistance in prepubertal children with obesity". Life Sciences (2023): https://doi.org/10.1016/j.lfs.2022.121246.
    10.1016/j.lfs.2022.121246
  13. Ermelindo Carreira Leal; Eugenia Carvalho. "Heme Oxygenase-1 as Therapeutic Target for Diabetic Foot Ulcers". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms231912043.
    10.3390/ijms231912043
  14. M. Graça Pereira; Margarida Vilaça; Eugenia Carvalho. "Effectiveness of Two Stress Reduction Interventions in Patients with Chronic Diabetic Foot Ulcers (PSY-DFU): Protocol for a Longitudinal RCT with a Nested Qualitative Study Involving Family Caregivers". International Journal of Environmental Research and Public Health (2022): https://doi.org/10.3390/ijerph19148556.
    10.3390/ijerph19148556
  15. Iva Fernandes; Joana Oliveira; Aryane Pinho; Eugenia Carvalho. "The Role of Nutraceutical Containing Polyphenols in Diabetes Prevention". Metabolites (2022): https://doi.org/10.3390/metabo12020184.
    10.3390/metabo12020184
  16. Diana Santos; Eugenia Carvalho. "Adipose-related microRNAs as modulators of the cardiovascular system: the role of epicardial adipose tissue". The Journal of Physiology (2021): https://doi.org/10.1113/JP280917.
    10.1113/JP280917
  17. Pedro Barbosa; Stepan Melnyk; Sirish C. Bennuri; Leanna Delhey; Andreia Reis; Gabriela R. Moura; Elisabet Børsheim; et al. "Redox Imbalance and Methylation Disturbances in Early Childhood Obesity". Oxidative Medicine and Cellular Longevity (2021): https://doi.org/10.1155/2021/2207125.
    10.1155/2021/2207125
  18. Hélia Fernandes; João Moura; Eugénia Carvalho; H. Fernandes; João Moura Alves; Carvalho, Eugenia. "mTOR Signaling as a Regulator of Hematopoietic Stem Cell Fate". Stem Cell Reviews and Reports (2021): https://doi.org/10.1007/s12015-021-10131-z.
    Aceite para publicação • 10.1007/s12015-021-10131-z
  19. Isadora Pombeiro; João Moura; Maria Graça Pereira; Eugénia Carvalho. "Stress-Reducing Psychological Interventions as Adjuvant Therapies for Diabetic Chronic Wounds". Current Diabetes Reviews (2021): https://doi.org/10.2174/1573399817666210806112813.
    10.2174/1573399817666210806112813
  20. Petkovic, Marija; Leal, Ermelindo C; Alves, Ines; Bose, Chanda; Palade, Philip T; Singh, Preeti; Awasthi, Sanjay; et al. "Dietary supplementation with sulforaphane ameliorates skin aging through activation of the Keap1-Nrf2 pathway". The Journal of Nutritional Biochemistry (2021): 108817. http://dx.doi.org/10.1016/j.jnutbio.2021.108817.
    10.1016/j.jnutbio.2021.108817
  21. Chen, Jin-Ran; Lazarenko, Oxana P; Carvalho, Eugenia; Blackburn, Michael L; Shankar, Kartik; Wankhade, Umesh D; Børsheim, Elisabet. "Short-Term Increased Physical Activity During Early Life Affects High-Fat Diet–Induced Bone Loss in Young Adult Mice". JBMR Plus 5 7 (2021): http://dx.doi.org/10.1002/jbm4.10508.
    10.1002/jbm4.10508
  22. Pinho, Aryane Cruz Oliveira; Ana Burgeiro; Maria João Rodrigues Pereira (1513-EB2F-0D7F); Carvalho, Eugenia; ARYANE C.O. PINHO; MARIA JOÃO PEREIRA; EUGENIA CARVALHO. "Drug-induced metabolic alterations in adipose tissue - with an emphasis in epicardial". Annals of the Brazilian Academy of Sciences 94 1 (2021): https://doi.org/10.1590/0001-3765202220201819.
    Aceite para publicação • 10.1590/0001-3765202220201819
  23. Mouritzen MV; Petkovic, Marija; Qvist K; Poulsen SS; Alarico S; Leal, EC; Dalgaard LT; et al. "Improved diabetic wound healing by bovine lactoferricin is associated with relevant changes in the skin immune response and microbiota". Molecular Therapy - Methods & Clinical Development (2021):
    Aceite para publicação
  24. Bose, Chhanda; Alves, Ines; Singh, Preeti; Palade, Philip T.; Carvalho, Eugenia; Børsheim, Elisabet; Jun, Se-Ran; et al. "Sulforaphane prevents age-associated cardiac and muscular dysfunction through Nrf2 signaling". Aging Cell 19 11 (2020): http://dx.doi.org/10.1111/acel.13261.
    10.1111/acel.13261
  25. Petkovic, Marija; Sørensen, Anja Elaine; Leal, Ermelindo Carreira; Carvalho, Eugenia; Dalgaard, Louise Torp. "Mechanistic Actions of microRNAs in Diabetic Wound Healing". Cells 9 10 (2020): 2228. http://dx.doi.org/10.3390/cells9102228.
    10.3390/cells9102228
  26. Figueiredo, Ana; Leal, Ermelindo C.; Carvalho, Eugénia. "Protein tyrosine phosphatase 1B inhibition as a potential therapeutic target for chronic wounds in diabetes". Pharmacological Research 159 (2020): 104977. http://dx.doi.org/10.1016/j.phrs.2020.104977.
    10.1016/j.phrs.2020.104977
  27. Jun, Se-Ran; Cheema, Amrita; Bose, Chhanda; Boerma, Marjan; Palade, Philip T.; Carvalho, Eugenia; Awasthi, Sanjay; Singh, Sharda P.. "Multi-Omic Analysis Reveals Different Effects of Sulforaphane on the Microbiome and Metabolome in Old Compared to Young Mice". Microorganisms 8 10 (2020): 1500. http://dx.doi.org/10.3390/microorganisms8101500.
    10.3390/microorganisms8101500
  28. Pedro, Joana Reis; Moura, Liane I.F.; Valério-Fernandes, Ângela; Baptista, Filipa I.; Gaspar, Joana M.; Pinheiro, Bárbara S.; Lemos, Cristina; et al. "Transient gain of function of cannabinoid CB1 receptors in the control of frontocortical glucose consumption in a rat model of Type-1 diabetes". Brain Research Bulletin 161 (2020): 106-115. http://dx.doi.org/10.1016/j.brainresbull.2020.05.004.
    10.1016/j.brainresbull.2020.05.004
  29. Seraphim, Patricia M.; Leal, Ermelindo C.; Moura, João; Gonçalves, Pedro; Gonçalves, Jenifer P.; Carvalho, Eugénia. "Lack of lymphocytes impairs macrophage polarization and angiogenesis in diabetic wound healing". Life Sciences 254 (2020): 117813. http://dx.doi.org/10.1016/j.lfs.2020.117813.
    10.1016/j.lfs.2020.117813
  30. Carvalho, Eugenia; Adams, Sean H.; Børsheim, Elisabet; Blackburn, Michael L.; Ono-Moore, Kikumi D.; Cotter, Matthew; Bowlin, Anne K.; Yeruva, Laxmi. "Neonatal diet impacts liver mitochondrial bioenergetics in piglets fed formula or human milk". BMC Nutrition 6 1 (2020): http://dx.doi.org/10.1186/s40795-020-00338-7.
    10.1186/s40795-020-00338-7
  31. Rose, Shannon; Carvalho, Eugenia; Diaz, Eva C.; Cotter, Matthew; Bennuri, Sirish C.; Azhar, Gohar; Frye, Richard E.; Adams, Sean H.; Børsheim, Elisabet. "A comparative study of mitochondrial respiration in circulating blood cells and skeletal muscle fibers in women". American Journal of Physiology-Endocrinology and Metabolism 317 3 (2019): E503-E512. http://dx.doi.org/10.1152/ajpendo.00084.2019.
    10.1152/ajpendo.00084.2019
  32. Henriques-Antunes, Helena; Cardoso, Renato M. S.; Zonari, Alessandra; Correia, Joana; Leal, Ermelindo C.; Jiménez-Balsa, Adrián; Lino, Miguel M.; et al. "The Kinetics of Small Extracellular Vesicle Delivery Impacts Skin Tissue Regeneration". ACS Nano 13 8 (2019): 8694-8707. http://dx.doi.org/10.1021/acsnano.9b00376.
    10.1021/acsnano.9b00376
  33. Moura, João; Rodrigues, João; Gonçalves, Marta; Amaral, Cláudia; Lima, Margarida; Carvalho, Eugénia. "Imbalance in T-cell differentiation as a biomarker of chronic diabetic foot ulceration". Cellular & Molecular Immunology (2019): http://dx.doi.org/10.1038/s41423-019-0233-1.
    10.1038/s41423-019-0233-1
  34. Moura, João; Sørensen, Anja; Leal, Ermelindo C.; Svendsen, Rikke; Carvalho, Lina; Willemoes, Rie Juul; Jørgensen, Per Trolle; et al. "microRNA-155 inhibition restores Fibroblast Growth Factor 7 expression in diabetic skin and decreases wound inflammation". Scientific Reports 9 1 (2019): http://dx.doi.org/10.1038/s41598-019-42309-4.
    10.1038/s41598-019-42309-4
  35. Carvalho, Eugenia. "Establishing a Link Between Endothelial Cell Metabolism and Vascular Behaviour in a Type 1 Diabetes Mouse Model". Cellular Physiology and Biochemistry 52 3 (2019): 503-516. http://dx.doi.org/10.33594/000000036.
    10.33594/000000036
  36. Moura, J.; Madureira, P.; Leal, E.C.; Fonseca, A.C.; Carvalho, E.. "Immune aging in diabetes and its implications in wound healing". Clinical Immunology 200 (2019): 43-54. http://dx.doi.org/10.1016/j.clim.2019.02.002.
    10.1016/j.clim.2019.02.002
  37. Liane I.F. Moura; Cristina Lemos; Catherine Ledent; Eugénia Carvalho; Attila Köfalvi. "Chronic insulinopenia/hyperglycemia decrease cannabinoid CB1 receptor density and impair glucose uptake in the mouse forebrain". Brain Research Bulletin (2019): https://doi.org/10.1016/j.brainresbull.2019.01.024.
    10.1016/j.brainresbull.2019.01.024
  38. Louise T. Dalgaard; Eugenia Carvalho. "Wanted: MicroRNAs to the aid of the diabetic foot". Trends in Cardiovascular Medicine (2018): https://doi.org/10.1016/j.tcm.2018.09.002.
    10.1016/j.tcm.2018.09.002
  39. Ana Catarina R. G. Fonseca; Eugénia Carvalho; Jan W. Eriksson; Maria J. Pereira. "Calcineurin is an important factor involved in glucose uptake in human adipocytes". Molecular and Cellular Biochemistry 445 1-2 (2018): 157-168. https://doi.org/10.1007/s11010-017-3261-0.
    10.1007/s11010-017-3261-0
  40. Michelle V. Mouritzen; Sali Abourayale; Rooshanie Ejaz; Christine B. Ardon; Eugenia Carvalho; Louise T. Dalgaard; Martin Roursgaard; Håvard Jenssen. "Neurotensin, substance P, and insulin enhance cell migration". Journal of Peptide Science 24 7 (2018): e3093-e3093. https://doi.org/10.1002/psc.3093.
    10.1002/psc.3093
  41. Marquis, Bryce J; Hurren, Nicholas M; Carvalho, Eugenia; Kim, Il-Young; Schutzler, Scott; Azhar, Gohar; Wolfe, Robert R; Børsheim, Elisabet. "Skeletal Muscle Acute and Chronic Metabolic Response to Essential Amino Acid Supplementation in Hypertriglyceridemic Older Adults". Current Developments in Nutrition 1 11 (2017): e002071. http://dx.doi.org/10.3945/cdn.117.002071.
    10.3945/cdn.117.002071
  42. Moura J; Rodrigues J; Gonçalves M; Amaral C; Lima M; Carvalho E. "Impaired T-cell differentiation in diabetic foot ulceration.". Cellular & molecular immunology (2017): http://europepmc.org/abstract/med/26996067.
    10.1038/cmi.2015.116
  43. Burgeiro A; Cerqueira MG; Varela-Rodríguez BM; Nunes S; Neto P; Pereira FC; Reis F; Carvalho E. "Glucose and Lipid Dysmetabolism in a Rat Model of Prediabetes Induced by a High-Sucrose Diet.". Nutrients (2017): http://europepmc.org/abstract/med/28635632.
    10.3390/nu9060638
  44. Pereira SG; Moura J; Carvalho E; Empadinhas N. "Microbiota of Chronic Diabetic Wounds: Ecology, Impact, and Potential for Innovative Treatment Strategies.". Frontiers in microbiology (2017): http://europepmc.org/abstract/med/28983285.
    10.3389/fmicb.2017.01791
  45. Emanuelli T; Burgeiro A; Carvalho E. "Effects of insulin on the skin: possible healing benefits for diabetic foot ulcers.". Archives of dermatological research (2016): http://europepmc.org/abstract/med/27655635.
    10.1007/s00403-016-1686-z
  46. García-Casarrubios E; de Moura C; Arroba AI; Pescador N; Calderon-Dominguez M; Garcia L; Herrero L; et al. "Rapamycin negatively impacts insulin signaling, glucose uptake and uncoupling protein-1 in brown adipocytes.". Biochimica et biophysica acta (2016): http://europepmc.org/abstract/med/27686967.
    10.1016/j.bbalip.2016.09.016
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    10.2337/db15-0340
  48. Carvalho E; Lopaschuk GD; Børsheim E; Burgeiro A. "Reply to Katlandur, Ozbek, and Keser.". American journal of physiology. Endocrinology and metabolism (2016): http://europepmc.org/abstract/med/27182058.
    10.1152/ajpendo.00113.2016
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    10.1152/ajpendo.00384.2015
  50. Carvalho, Eugenia. "Substance P Promotes Wound Healing in Diabetes by Modulating Inflammation and Macrophage Phenotype". Am J Pathol (2015): http://www.ncbi.nlm.nih.gov/pubmed/25871534.
  51. Sereno, J.; Vala, H.; Nunes, S.; Rocha-Pereira, P.; Carvalho, E.; Alves, R.; Teixeira, F.; Reis, F.. "Cyclosporine a-induced nephrotoxicity is ameliorated by dose reduction and conversion to sirolimus in the rat". Journal of Physiology and Pharmacology 66 2 (2015): 285-299. http://www.scopus.com/inward/record.url?eid=2-s2.0-84927565139&partnerID=MN8TOARS.
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  73. Pedroso, D.C.S.; Tellechea, A.; Moura, L.; Fidalgo-Carvalho, I.; Duarte, J.; Carvalho, E.; Ferreira, L.. "Improved survival, vascular differentiation and wound healing potential of stem cells co-cultured with endothelial cells". PLoS ONE 6 1 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-79551528768&partnerID=MN8TOARS.
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    10.1016/j.bbamcr.2011.06.018
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  79. Karagiannides, I.; Torres, D.; Tseng, Y.; Bowe, C.; Carvalho, E.; Espinoza, D.; Pothoulakis, C.; Kokkotou, E.. "Substance P as a Novel Anti-obesity Target". Gastroenterology 134 3 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-39749152943&partnerID=MN8TOARS.
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  80. Carvalho, E.; Kotani, K.; Peroni, O.D.; Kahn, B.B.. "Adipose-specific overexpression of GLUT4 reverses insulin resistance and diabetes in mice lacking GLUT4 selectively in muscle". American Journal of Physiology - Endocrinology and Metabolism 289 4 52-4 (2005): http://www.scopus.com/inward/record.url?eid=2-s2.0-23044440661&partnerID=MN8TOARS.
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  81. Carvalho, E.; Schellhorn, S.E.; Zabolotny, J.M.; Martin, S.; Tozzo, E.; Peroni, O.D.; Houseknecht, K.L.; et al. "GLUT4 overexpression or deficiency in adipocytes of transgenic mice alters the composition of GLUT4 vesicles and the subcellular localization of GLUT4 and insulin-responsive aminopeptidase". Journal of Biological Chemistry 279 20 (2004): 21598-21605. http://www.scopus.com/inward/record.url?eid=2-s2.0-2442636649&partnerID=MN8TOARS.
    10.1074/jbc.M312269200
  82. Yang, X.; Jansson, P.-A.; Nagaev, I.; Jack, M.M.; Carvalho, E.; Sunnerhagen, K.S.; Cam, M.C.; Cushman, S.W.; Smith, U.. "Evidence of impaired adipogenesis in insulin resistance". Biochemical and Biophysical Research Communications 317 4 (2004): 1045-1051. http://www.scopus.com/inward/record.url?eid=2-s2.0-1942484345&partnerID=MN8TOARS.
    10.1016/j.bbrc.2004.03.152
  83. Jansson, P.-A.; Pellmé, F.; Hammarstedt, A.; Sandqvist, M.; Brekke, H.; Caidahl, K.; Forsberg, M.; et al. "A novel cellular marker of insulin resistance and early atherosclerosis in humans is related to impaired fat cell differentiation and low adiponectin". FASEB Journal 17 11 (2003): 1434-1440. http://www.scopus.com/inward/record.url?eid=2-s2.0-0042209622&partnerID=MN8TOARS.
    10.1096/fj.02-1132com
  84. Carvalho, E.; Jansson, P.A.; Nagaev, I.; Wenthzel, A.M.; Smith, U.. "Insulin resistance with low cellular IRS-1 expression is also associated with low GLUT4 expression and impaired insulin-stimulated glucose transport.". The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 15 6 (2001): 1101-1103. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035316142&partnerID=MN8TOARS.
  85. Carvalho, E.; Rondinone, C.; Smith, U.. "Insulin resistance in fat cells from obese Zucker rats - Evidence for an impaired activation and translocation of protein kinase B and glucose transporter 4". Molecular and Cellular Biochemistry 206 1-2 (2000): 7-16. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034055787&partnerID=MN8TOARS.
  86. Smith, U.; Carvalho, E.; Mosialou, E.; Beguinot, F.; Formisano, P.; Rondinone, C.. "PKB inhibition prevents the stimulatory effect of insulin on glucose transport and protein translocation but not the antilipolytic effect in rat adipocytes". Biochemical and Biophysical Research Communications 268 2 (2000): 315-320. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034673376&partnerID=MN8TOARS.
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  87. Carvalho, E.; Eliasson, B.; Wesslau, C.; Smith, U.. "Impaired phosphorylation and insulin-stimulated translocation to the plasma membrane of protein kinase B/Akt in adipocytes from type II diabetic subjects". Diabetologia 43 9 (2000): 1107-1115. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033811737&partnerID=MN8TOARS.
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  88. Rondinone, C.M.; Carvalho, E.; Rahn, T.; Manganiello, V.C.; Degerman, E.; Smith, U.P.. "Phosphorylation of PDE3B by phosphatidylinositol 3-kinase associated with the insulin receptor". Journal of Biological Chemistry 275 14 (2000): 10093-10098. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034616384&partnerID=MN8TOARS.
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Livro
  1. Smith, U.; Axelsen, M.; Carvalho, E.; Eliasson, B.; Jansson, P.-A.; Wesslau, C.. Insulin signaling and action in fat cells: Associations with insulin resistance and Type 2 diabetes. 1999.
Tese / Dissertação
  1. Carvalho, Eugénia Maria Lourenço de. "Molecular Mechanisms of Insulin Resistance with Emphasis on IRS-1 and PKB/Akt". Doutoramento, 2018. http://hdl.handle.net/10316/80483.
  2. Carvalho, Eugénia; Carvalho, Rui. "Mechanisms underlying peripheral resistance in a rat model of prediabetes". Mestrado, 2015. http://hdl.handle.net/10316/31741.
  3. Carvalho, Eugénia; Palmeira, Carlos. "Molecular mechanisms involved in glucose and lipid metabolism after immunosuppressive therapy". Doutoramento, 2014. http://hdl.handle.net/10316/25248.
  4. Veves, Aristidis; Carvalho, Eugénia; Rosete, Maria Teresa Cruz. "Cellular and molecular mechanisms of impaired wound healing in diabetes : understanding the role of substance P and mast cells". Doutoramento, 2014. http://hdl.handle.net/10316/26466.
  5. Carvalho, Eugénia; Sousa, Hermínio C. de. "Development of novel therapeutic approaches for wound healing in diabetes". Doutoramento, 2013. http://hdl.handle.net/10316/23741.
  6. Carvalho, Eugénia; Valverde, Angela M.. "Mechanisms of Insulin Resistance after Immunosuppressive Therapy in Brown Adipose Tissue". Mestrado, 2013. http://hdl.handle.net/10316/24905.
  7. Pereira, Maria J.; Aureliano, M.; Carvalho, Eugénia. "Effects of immunosuppressive drugs on human adipose tissue metabolism". Doutoramento, 2012. http://hdl.handle.net/10400.1/4916.
  8. Carvalho, Eugénia; Duarte, Carlos; Canzoniero, Lorella. "Effects of cyclosporine A and sirolimus on glucose and lipid metabolism : an in vivo rat model". Mestrado, 2012. http://hdl.handle.net/10316/24988.
  9. Carvalho, Eugénia; Cruz, Maria Teresa; Castro, Margarida. "Neurotensin effect on skin dendritic cells and fibroblasts: repercussions in wound healing and diabetic wound healing". Mestrado, 2010. http://hdl.handle.net/10316/28818.

Outros

Outra produção
  1. Cyclosporine A and tacrolimus reduce the amount of GLUT4 at the cell-surface in human adipocytes: increased endocytosis as a potential mechanism for the diabetogenic effects of immunosuppressive agents. Context:Immunosuppressive agentes are associated with profound metabolic side effects including new-onset diabetes and dyslipidemia after organ transplantation. Objective: Toi nvestigated the effects of the cyclosporine A(CsA)or tacrolimus ong lucose uptake and insulin signalling in human adipocytes and their impact on the regulation of celular trafficking of the glucose transporter 4 (GLUT4). Des. 2014. Pereira, Maria João; Aureliano, M.; Palming, Jenny; Rizell, Magnus; Carvalho, Eugénia; Svensson, Maria K.; Eriksson, Jan W.; et al. http://hdl.handle.net/10400.1/4856.
    http://dx.doi.org/10.1210/jc.2014-1266
  2. Neurotensin-loaded collagen dressings reduce inflammation and improve wound healing in diabetic mice. Impaired wound healing is an important clinical problem in diabetes mellitus and results in failure to completely heal diabetic foot ulcers (DFUs), which may lead to lower extremity amputations. In the present study, collagen based dressings were prepared to be applied as support for the delivery of neurotensin (NT), a neuropeptide that acts as an inflammatory modulator in wound healing. The perfo. 2014. Moura, Liane I F; Dias, Ana M A; Suesca, Edward; Casadiegos, Sergio; Leal, Ermelindo C; Fontanilla, Marta R; Carvalho, Lina; et al. http://hdl.handle.net/10316/80404.
    10.1016/j.bbadis.2013.10.009
  3. Role of Endothelial Progenitor Cells and Inflammatory Cytokines in Healing of Diabetic Foot Ulcers. Background: To evaluate changes in endothelial progenitor cells (EPCs) and cytokines in patients with diabetic foot ulceration (DFU) in association with wound healing. Methods: We studied healthy subjects, diabetic patients not at risk of DFU, at risk of DFU and with active DFU. We prospectively followed the DFU patients over a 12-week period. We also investigated similar changes in diabetic rabbi. 2013. Tecilazich, Francesco; Dinh, Thanh; Pradhan-Nabzdyk, Leena; Leal, Ermelindo; Tellechea, Ana; Kafanas, Antonios; Gnardellis, Charalambos; et al. http://hdl.handle.net/10316/27674.
  4. mTOR inhibition with rapamycin cause impaired insulin signalling and glucose uptake in human subcutaneous and omental adipocytes. Rapamycin is an immunosuppressive agent used after organ transplantation, but its molecular effects on glucose metabolism needs further evaluation. We explored rapamycin effects on glucose uptake and insulin signalling proteins in adipocytes obtained via subcutaneous (n = 62) and omental (n = 10) fat biopsies in human donors. At therapeutic concentration (0.01 lM) rapamycin reduced basal and insul. 2012. Pereira, Maria João; Palming, Jenny; Rizell, Magnus; Aureliano, M.; Carvalho, Eugénia; Svensson, Maria K.; Eriksson, Jan W.; et al. http://hdl.handle.net/10400.1/1326.
    10.1016/j.mce.2012.01.024
  5. Improved Survival, Vascular Differentiation and Wound Healing Potential of Stem Cells Co-Cultured with Endothelial Cells. In this study, we developed a methodology to improve the survival, vascular differentiation and regenerative potential of umbilical cord blood (UCB)-derived hematopoietic stem cells (CD34+ cells), by co-culturing the stem cells in a 3D fibrin gel with CD34+-derived endothelial cells (ECs). ECs differentiated from CD34+ cells appear to have superior angiogenic properties to fully differentiated ECs. 2011. Pedroso, Dora C. S.; Tellechea, Ana; Moura, Liane; Fidalgo-Carvalho, Isabel; Duarte, João; Carvalho, Eugénia; Ferreira, Lino. http://hdl.handle.net/10316/14426.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2020 MicroRNAs - biomarkers and therapeutic targets in diabetic chronic wounds SPD2020
2019/04/14 Increased PBMC mitochondrial ATP production in obese insulin resistant children is associated with metabolic dysfunction and inflammation Keystone Symposia Conference - Immunometabolism, Metaflammation and Metabolic Disorders
Keystone Symposia (Vancouver, Canadá)
2019/01/04 Boosting the wound-local immune system to modulate infection, 2nd Wound Healing Workshop, DDA; Denmark, January, 2019 Wound Healing Workshop (2nd)
Roskilde University (Roskilde, Dinamarca)
2018 Public Health Concerns and awareness about Diabetes in Guine-Bissau, January 2018 Public Health
Coimbra Hotel (Bissau, Guiné-Bissau)
2017/09 Endoplasmic reticulum stress and autophagy are impaired in epicardial adipose tissue from heart failure subjects. 53rd European Association for the Study of Diabetes Annual Meeting, Lisbon, Portugal, Diabetologia Supplement, September, 2017 European Association for the Study of Diabetes Annual Meeting
European Association for the Study of Diabetes (Lisbon, Portugal)
2017/07 Bioenergetics and fatty acid oxidation – how health in the young determines health in the elderly, Center for Neurosciences and Cell Biology, Coimbra, Portugal, July 2017 Center for Neurosciences and Cell Biology
Center for Neurosciences and Cell Biology (Coimbra, Portugal)
2017/05 The metabolic (molecular) phenotype of epicardial adipose tissue. European Congress on Obesity, Porto, Portugal, May 2017 European Congress on Obesity
European Congress on Obesity (Porto, Portugal)
2017 Early skin aging in diabetes is associated with a decrease in CB1 cannabinoid receptor expression. 53rd European Association for the Study of Diabetes Annual Meeting, Lisbon, Portugal, Diabetologia Supplement, September, 2017 Early skin aging in diabetes is associated with a decrease in CB1 cannabinoid receptor expression
European Association for the Study of Diabetes Annual Meeting (Lisbon, Portugal)
2017 Regulation of miRNA-146a and miR-29a during wound healing in a mouse model of type 1 diabetes. 53rd European Association for the Study of Diabetes Annual Meeting, Lisbon, Portugal, Diabetologia Supplement, September, 2017 European Association for the Study of Diabetes
European Association for the Study of Diabetes (Lisbon, Portugal)
2016/07 Diabetes and Obesity Complications in the Modern World, Institute of Biomedicine – iBiMED, Aveiro, Portugal, July 2016 iBiMED
iBiMED (Aveiro, Portugal)
2016/07 From rural Portugal to a career as a research scientist: a woman’s journey into science, Center for Neurosciences and Cell Biology, Coimbra, Portugal Center for Neurosciences and Cell Biology
Center for Neurosciences and Cell Biology (Cantanhede, Portugal)
2016/04 EAT - What do we know, UAMS College of Medicine Donald W. Reynolds Department of Geriatrics, Little Rock, AR UAMS College of Medicine Donald W. Reynolds
UAMS College of Medicine Donald W. Reynolds (Little Rock, AR, Estados Unidos)
2015/04 Therapeutic targets for the treatment of wound healing in diabetes. Diabetes Wound Healing Workshop. March 30-31, 2015. Roskilde University, Denmark. Diabetes Wound Healing Workshop
Roskilde University (Roskilde, Dinamarca)
2015 The Role of Neuropeptides in Wound Healing in Diabetes, Geriatrics Grand Rounds, UAMS, COM, Donald W. Reynolds Department of Geriatrics, Little Rock, AR UAMS, COM, Donald W. Reynolds
UAMS, COM, Donald W. Reynolds (Little Rock, AR, Estados Unidos)
2014 Molecular mechanisms of insulin resistance – the adipocyte, Division of Endocrinology and Metabolism and the UAMS Center for Osteoporosis and Metabolic Bone Diseases in the UAMS Department of Internal Medicine. Little Rock, AR UAMS Department of Internal Medicine
UAMS Department of Internal Medicine (Little Rock, AR, Estados Unidos)
2014 The adipocyte and its cross-talk with other tissues, Arkansas Children’s Hospital Research Institute; Little Rock, AR Arkansas Children’s Hospital Research Institute
Arkansas Children’s Hospital Research Institute (Little Rock, Ar, Estados Unidos)
2013 The fat cell as an endocrine organ – its cross talk with other tissues, University of Arkansas for Medical Sciences, Aging Center Research Seminar, Little Rock, AR University of Arkansas for Medical Sciences
University of Arkansas for Medical Sciences (Little Rock, AR, Estados Unidos)
2013 Fat metabolism and immunosuppressive therapy, University of Texas Medical Branch at Galveston, TX, USA University of Texas Medical Branch at Galveston
University of Texas Medical Branch at Galveston (Galveston, TX, Estados Unidos)
2013 The Role of Neuropeptides in Wound Healing in Diabetes, University of Texas Medical Branch at Galveston, USA University of Texas Medical Branch at Galveston
University of Texas Medical Branch at Galveston (Galveston, TX, Estados Unidos)
2013 The adipocyte as an endocrine organ, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA The adipocyte as an endocrine organ
Beth Israel Deaconess Medical Center, Harvard Medical School, (Boston, MA, Estados Unidos)
2012 Molecular mechanisms of wound healing in diabetes, Wallenberg Lab, Goteborg, Sweden Molecular mechanisms of wound healing in diabetes
Wallenberg Lab (Gothenburg, Suécia)
2011 From rural Portugal to a career as a research scientist: a woman’s journey into science, University of Minho, Braga, Portugal University of Minho
University of Minho (Braga, Portugal)
2011 Wound healing in diabetes, Instituto Investigaciones Biomedicas Alberto Sols, Madrid, Spain Instituto Investigaciones Biomedicas Alberto Sols
Instituto Investigaciones Biomedicas Alberto Sols (Madrid, Espanha)
2011 Molecular Biology of the Metabolic Syndrome. CEDOC, University Nova, Lisbon, Portugal CEDOC, University Nova
CEDOC, University Nova (Lisbon, Portugal)
2010 Insulin resistance, the metabolic syndrome, Portuguese Institute of Oncology, IPO, Lisbon, Portugal Portuguese Institute of Oncology, IPO
Portuguese Institute of Oncology, IPO (Lisbon, Portugal)
2010 PTP1B regulates wound healing. Insulin Receptor Meeting, Naples, Italy Insulin Receptor Meeting
Insulin Receptor Meeting (Naples, Itália)
2010 Immunosupressive agents alter glucose metabolism and blood pressure in rats, Insulin Receptor Meeting, Naples, Italy Insulin Receptor Meeting
Insulin Receptor Meeting (Naples, Itália)
2010 Health talk: Chronic diseases, University of the Algarve, Faro, Portugal University of the Algarve
University of the Algarve (Faro)
2009 The role of neuropeptides in wound healing, University Nova de Lisbon, Portugal University Nova
University Nova (Lisbon, Portugal)
2009 Genetics, molecular biology and obesity. International Symposium of Surgery, Portugal International Symposium of Surgery
International Symposium of Surgery (Coimbra, Portugal)
2008 Substance P in wound healing. EFSD/Lilly Symposium, Bad Homburg, Germany EFSD/Lilly Symposium
EFSD/Lilly Symposium (Bad Homburg, Alemanha)
2008 The role of neuropeptides in wound healing. EASD Training Course, Helsinki, Finland EASD Training Course
EASD Training Course (Helsinki, Finlândia)
2008 The role of Substance P in wound healing. American Diabetes Association (ADA), San Francisco, USA American Diabetes Association (ADA)
American Diabetes Association (ADA) (San Francisco, Estados Unidos)
2008 The role of neuropeptides in wound healing. University of Coimbra, Portugal University of Coimbra
University of Coimbra (Coimbra, Portugal)
2008 Obesity a disease of the XXI century, III Workshop in Clinical Biochemistry, Porto, Portugal III Workshop in Clinical Biochemistry
III Workshop in Clinical Biochemistry (Porto, Portugal)
2006 O adipócito: vilão ou vitima, 10th Nacional Portuguese Obesity Congress, Porto, Portugal 10th Nacional Portuguese Obesity Congress,
10th Nacional Portuguese Obesity Congress, (Porto, Portugal)
2006 The adipocyte as an endocrine organ. Fórum Internacional de Investigadores Portugueses (FIIP), Porto, Portugal Fórum Internacional de Investigadores Portugueses (FIIP)
Fórum Internacional de Investigadores Portugueses (FIIP) (Porto, Portugal)
2006 Insulin resistance: “healthy” humans and transgenic mice, University of Georgia, GA, USA University of Georgia
University of Georgia (Athens, GA, Estados Unidos)
2006 The importance of the adipocyte. Novartis. Boston, MA, USA Novartis
Novartis (Boston, MA, Estados Unidos)
2006 Insulin resistance in “healthy” humans and in transgenic mice - the importance of the adipocyte. Boston Biomedical Research Institute, Boston, MA, USA Boston Biomedical Research Institute
Boston Biomedical Research Institute (Boston, MA, Estados Unidos)
2005 Insulin resistance a familial syndrome. Symposium on Diabetes Mellitus, Algarve, Portugal Symposium on Diabetes Mellitus
Symposium on Diabetes Mellitus (Faro, Portugal)
2005 The adipocyte as an endocrine organ. University of the Algarve, Faro, Portugal University of the Algarve,
University of the Algarve, (Faro, Portugal)
2005 The adipocyte as an endocrine organ. Tufts University, Boston, MA, USA Tufts University
Tufts University (Boston, MA, Estados Unidos)
2004 Insulin resistance in “healthy” humans and in transgenic mice - the importance of the adipocyte. Synta Pharmaceuticals, Boston, MA, USA Synta Pharmaceuticals
Synta Pharmaceuticals (Boston, MA, Estados Unidos)
2004 Insulin resistance in humans and in transgenic mice - the importance of the adipocyte. University of Gothenburg, Gothenburg, Sweden University of Gothenburg
University of Gothenburg (Gothenburg, Suécia)
2004 Insulin resistance in “healthy” humans and in transgenic mice - the importance of the adipocyte, AstraZeneca, Molndal, Sweden AstraZeneca
AstraZeneca (Molndal, Suécia)
2004 The adipocyte as an endocrine organ. Joslin Diabetes Center, Boston, MA, USA Joslin Diabetes Center
Joslin Diabetes Center (Boston, Estados Unidos)
2001 Molecular Mechanisms of Insulin Resistance in Fat Cells. International Symposium on Insulin Receptor and Insulin Action, Geneve, Switzerland International Symposium on Insulin Receptor and Insulin Action
International Symposium on Insulin Receptor and Insulin Action (Geneve, Suiça)
2001 Low cellular IRS-1 gene and protein expression predict insulin resistance in “healthy” humans. Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA Harvard Medical School
Harvard Medical School (Boston, MA, Estados Unidos)
2001 Molecular mechanisms of insulin resistance with emphasis on IRS-1 and PKB/Akt. At the meeting of the Annual Swedish Foundation for the Study of Diabetes, Sweden, Swedish Foundation for the Study of Diabetes
Swedish Foundation for the Study of Diabetes (Gothenburg, Suécia)
1999 Impaired glucose transport by insulin, but not okadaic acid, in adipocytes from subjects with Type II diabetes mellitus. ADA, the 59th Scientific sessions, San Diego, CA, USA ADA, the 59th Scientific sessions
ADA, the 59th Scientific sessions (San Diego, CA, Estados Unidos)
1993 Mechanisms of inhibition in angiotensin I-converting enzyme. FEBS International Summer School on Molecular and Cellular Biology, on Spetsai, Greece FEBS International Summer School on Molecular and Cellular Biology
FEBS International Summer School on Molecular and Cellular Biology (Spetses, Grécia)
1993 One or two inhibitor-binding sites in angiotensin I-converting enzyme? INSERM (Institut National de la Santéet de la Recherche Medicale), Paris, France INSERM
INSERM (Paris, França)

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2022/10/01 - 2027/12/01 Creation of an Implementation Science and Health Literacy (nutrition and diabetes) advanced course at the University of Coimbra, presented online to the Doctoral Program at the Faculty of Pharmacy and the PhD program in Experimental Biology and Biomedicine, but also open to the public, since 2022. (Outros)

Expedição científica

Descrição da atividade Instituição / Organização
2022/12/01 - 2027/12/01 Field studies in Guinea-Bissau West Africa on the prevalence of diabetes, obesity and hypertension. Launching of the Guinean Annual Diabetes meeting, that started in 2023. Reached over 10 000 people with capacitation and diabetes literacy around the country, including messages through community radio in the various most spoken local languages. Working with the Civil Society to reach out to many more people, for diabetes screenings and literacy.
Distinções

Prémio

2021 Expertscape's PubMed-based algorithms place you in the top 1% of scholars writing about Foot Ulcers over the past 10 years, a level we label as "Expert."

Outra distinção

2019 Senior Editor for Journal of Endocrinology and Journal of Molecular Endocrinology
2019 Board Member of the European Tissue Repair Society (ETRS)
2012 AD HOC International Grant Reviewer
2001 Post-Doctoral Training
2000 AD HOC Reviewer for scientific journals (over 35 Journal)
1999 Professional memberships