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Cláudia Lobato da Silva (CLS) received a Diploma in Chemical Engineering (Biotechnology), Instituto Superior Técnico (IST), Technical University of Lisboa (TUL) Portugal, in 2001, and got a PhD in Biotechnology in 2006 at IST-TUL in collaboration with the University of Nevada, USA. In 2007, CLS was hired as ¿Invited Assistant Professor¿ within the frame of the MIT-Portugal Program, and then initiating a 5-year Tenure-Track position (2008-2013) as Assistant Professor at Department of Chemical & Biological Engineering/Department of Bioengineering (DBE) at IST. Presently, CLS is Associate Professor (since 2019; Assistant Professor 2007-2018) at DBE-IST. Over the last years, CLS has been developing her pedagogical activities within the Scientific Area of Biomaterials, Nanotechnologies and Regenerative Medicine at DBE-IST teaching and coordinating several courses at BSc, MSc and PhD level, being awarded with the Diploma of Excellence in Teaching by the Pedagogical Council of IST since 2007/2008. Since 2019, CLS has assumed several coordination activities within educational programs of IST, being the Coordinator/Vice-Coordinator of BSc/MSc cycles in Biomedical Engineering since 2021, and member of the Scientific Committee of Doctoral Program in Bioengineering. In 2017-2022, CLS served as member of the Pedagogical Council of IST and since 2023 is member of the Scientific Council of IST. CLS has developed her research activities at iBB-Institute for Bioengineering and Biosciences, Stem Cell Research Engineering Group (SCERG), where she coordinates the ¿Development and Manufacturing of Cellular & Molecular Therapies¿ Focus Area and is the PI of the Modulation of the Stem Cell Niche lab. Her research is developed within the thematic line TL2- Advanced Diagnostics and Therapies of the Associated Laboratory i4HB-Institute for Health and Bioeconomy. Her main research focus has been on the ex-vivo expansion of human stem/progenitor cells aiming at innovating the clinical manufacturing of cell-based therapies. The research developed has been funded through competitive research grants and also by patient organizations/clinical organizations and the industry (>1.03 M¿ raised in the last 5 years). Of notice, CLS is coordinating (national coordinator) key WPs in 2 H2020 funded projects: AMELIE - Anchored Muscle cELls for IncontinencE and UROPRINT - Urinary bladder bioprinting for fully autologous transplantation. As a result of the research activities developed, CLS edited 2 books and has authored 21 book chapters, 1 national patent and 97 scientific articles in peer-reviewed international ISI-indexed journals (h-index of 35, >3450 citations, according to ISI Web of Knowledge (accessed on February 2024). CLS supervised/co-supervised 10 Post-doctoral researchers, 32 PhD students (11 as main supervisor) and more than 40 Master students, who developed their research in the field of Stem Cell Engineering and Regenerative Medicine. In 2015-2019, CLS served as the Vice-President of the Portuguese Society for Stem Cells and Cellular Therapies (SPCE-TC)). CLS participated as Evaluation Panel member of the National FCT Call for individual PhD fellowships (Bioengineering and Biotechnology) in 2015 and served as Research Grant Peer Reviewer, Regenerative Medicine Research, for Medical Research Council (MRC), UK in 2013 & 2018.
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Identificação

Identificação pessoal

Nome completo
Cláudia Alexandra Martins Lobato da Silva

Nomes de citação

  • Silva, Cláudia
  • da Silva CL

Identificadores de autor

Ciência ID
601D-DE5F-A9B0
ORCID iD
0000-0002-1091-7651
Researcher Id
K-6104-2012
Scopus Author Id
22933449000

Telefones

Telefone
  • 218419969 Ext.: 3969 (Profissional)

Moradas

  • Instituto Superior Técnico Avenida Rovisco Pais, 1049-001, Lisboa, Lisboa, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Biotecnologia Médica - Biotecnologia Aplicada à Saúde
  • Ciências da Engenharia e Tecnologias - Engenharia Médica - Engenharia Médica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Formação
Grau Classificação
2006/03/01 - 2007/06/30
Concluído
 Stem Cell Bioengineering (Pós-doutoramento)
Instituto de Biotecnologia e Bioengenharia, Portugal
2002/01/01 - 2006/02/14
Concluído
 Biotechnology (Doutoramento)
Especialização em Stem Cell Bioengineering
Instituto Superior Técnico, Universidade Técnica de Lisboa, Portugal
"A human stromal-based serum-free culture system for the ex-vivo expansion/maintenance of hematopoietic stem/progenitor cells" (TESE/DISSERTAÇÃO)
 Pass
1996/09/01 - 2001/12/15
Concluído
 Chemical Engineering (Licenciatura)
Especialização em Biotechnology
Instituto Superior Técnico, Universidade Técnica de Lisboa, Portugal
 17
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2019/10/01 - Atual Investigador principal (carreira) (Investigação) Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
2007/07/01 - 2014/12/31 Investigador (Investigação) Instituto de Biotecnologia e Bioengenharia, Portugal
2006/03/01 - 2007/06/30 Pós-doutorado (Investigação) Centre for Biological and Chemical Engineering - Instituto Superior Técnico, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2019/10/01 - Atual Professor Associado (Docente Universitário) Universidade de Lisboa Instituto Superior Técnico, Portugal
2008/07/01 - 2019/09/30 Professor Auxiliar (Docente Universitário) Universidade de Lisboa Instituto Superior Técnico, Portugal
2007/07/01 - 2008/06/30 Professor Auxiliar Convidado (Docente Universitário) Universidade de Lisboa Instituto Superior Técnico, Portugal

Cargos e Funções

Categoria Profissional
Instituição de acolhimento 		Empregador
2023/01 - Atual Member of the Scientific Council Instituto Superior Técnico, Universidade de Lisboa, Portugal
Instituto Superior Técnico, Universidade de Lisboa, Portugal
2021/09 - Atual Coordinator of the Bachelor Degree in Biomedical Engineering Instituto Superior Técnico, Universidade de Lisboa, Portugal
Instituto Superior Técnico, Universidade de Lisboa, Portugal
2017/01 - 2022/12 Plenary Member of the Pedagogical Council Instituto Superior Técnico, Universidade de Lisboa, Portugal
Instituto Superior Técnico, Universidade de Lisboa, Portugal
Projetos

Bolsa

Designação Financiadores
2020/09/01 - 2025/08/31 H2020 AMELIE: Anchored Muscle cELls for IncontinencE
874807
Investigador
University College London Faculty of Medical Sciences, Reino Unido

Instituto Superior Técnico, Universidade de Lisboa, Portugal
EU Framework Programme for Research and Innovation Science with and for Society
Em curso
2021/09/01 - 2025/08/30 H2020 UROPRINT - Urinary bladder bioprinting for fully autologous transplantation
964883
Investigador
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON - BIOMEDICAL RESEARCH FOUNDATION, ACADEMY OF ATHENS, Grécia
EU Framework Programme for Research and Innovation ICT Leadership in Enabling and Industrial Technologies
Em curso
2021/03 - 2025/02 Exploiting the power of decellularized extracellular matrix to fabricate hierarchical biomimetic scaffolds to regenerate functional periodontal tissues
PTDC/BTM-MAT/3538/2020
Investigador
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2022/01 - 2024/12 Quality by design-centered platform for the manufacturing of CAR-engineered NK cells and extracellular vesicles for immunotherapy
PTDC/EQU-EQU/3708/2021
Investigador
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2017/04 - 2024/03 The DISCOVERIES CENTRE for REGENERATIVE and PRECISION MEDICINE
H2020-WIDESPREAD-01-2016-2017_TeamingPhase2
 European Commission
2018/11 - 2021/10 Development of a scalable manufacturing process for therapeutic human mesenchymal stem/stromal cell-derived exosomes
18/06994-1
Investigador
Fundação de Amparo à Pesquisa do Estado de São Paulo
2018/08 - 2021/07 NEUROAbetaCLEAR - Engineering of Smart Exosomes for Amyloid-beta Clearance in Alzheimer disease
PTDC/BTM-SAL/31057/2017
 Governo da República Portuguesa Ministério da Ciência Tecnologia e Ensino Superior
2016/12 - 2019/11 PAC PRECISE - Accelerating progress toward the new era of precision medicine
SAICTPAC/0021/2015
 Fundo Regional para a Ciência e Tecnologia
2015/10 - 2018/09 Design and operation of a prototype packed-bed reactor for the production of hematopoietic stem/progenitor cells
Provided by PTCRIS: 145265
Investigador
Fundação para a Ciência e a Tecnologia
2014/05 - 2018 CARDIOSTEM- Engineered cardiac tissues and stem cell-based therapies for cardiovascular applications
MITP-TB/ECE/0013/2013
 Governo da República Portuguesa Ministério da Ciência Tecnologia e Ensino Superior
2013/03 - 2016/02 Induction of Immune Tolerance in Human Allogeneic Hematopoietic Stem Cell Transplantation
123713
Provided by PTCRIS: 123713
 Fundação para a Ciência e a Tecnologia, I.P.
2014/04 - 2015/03 CARDIOSAFER -Safety and efficacy of intracoronary mesenchymal stem/stromal cell (MSC)-based therapy for myocardial regeneration: a microcirculation study
Provided by PTCRIS: 134995
134995
Investigador responsável
Fundação para a Ciência e a Tecnologia, I.P.
2013/04 - 2014/03 Development of a novel adoptive cell therapy for leukemia: characterization and optimization of gamma-delta T lymphocytes for clinical application.
Provided by PTCRIS: 126020
126020
 Fundação para a Ciência e a Tecnologia, I.P.
2011/01 - 2013/12 Scalable Reactor Systems for the Production of Human Mesenchymal Stem Cells
114231
Provided by PTCRIS: 114231
Investigador responsável
Fundação para a Ciência e a Tecnologia, I.P.
2010/01 - 2012/12 Integrated Process for the Expansion and Neural Differentiation of Human Embryonic Stem Cells in Stirred Suspension Bioreactors
105277
Provided by PTCRIS: 105277
 Fundação para a Ciência e a Tecnologia, I.P.
2010/01 - 2012/12 STEMSELECT - Novel integrated process for human hematopoietic stem cell isolation and ex-vivo expansion
Provided by PTCRIS: 104663
104663
 Fundação para a Ciência e a Tecnologia, I.P.
2009/04 - 2012/06 Smart small-scale devices: systems for controlled delivery of bioactive molecules, cell expansion and for sensing cell environment.
Provided by PTCRIS: 83907
83907
 Fundação para a Ciência e a Tecnologia, I.P.
2007/10 - 2010/12 Biological and Molecular Characterization of Avian Influenza Viruses and Development of DIVA Tests
67189
Provided by PTCRIS: 67189
 Fundação para a Ciência e a Tecnologia, I.P.
2007/10 - 2010/10 STEM CELL LAB ON CHIP: MAGNETIC CELL SEPARATOR AND DISCRIMINATOR PLATFORMS
Provided by PTCRIS: 68617
68617
 Fundação para a Ciência e a Tecnologia, I.P.
2005/04 - 2007/12 Friction and wear mechanisms in orthopaedic prostheses: influence of the composition of the periprosthetic fluid.
55493
Provided by PTCRIS: 55493
Provided by PTCRIS: 82512
82512
 Fundação para a Ciência e a Tecnologia, I.P.
2005/02 - 2007/02 Ex vivo Expansion of Hematopoietic Stem Cells in an Immobilized Fluidized Bed Stromal Cell Reactor
Provided by PTCRIS: 37641
 Fundação para a Ciência e a Tecnologia
2002/01 - 2004/12 Design, Operation and Modelling of a Ceramic Membrane Stromal Cell Reactor for Hematopoietic Stem Cell Culture
Provided by PTCRIS: 38063
 Fundação para a Ciência e a Tecnologia

Projeto

Designação Financiadores
2021/02 - Atual Isolation, scalable expansion of human mesenchymal stem/stromal cells (MSCs) and production of MSC-derived extracellular vesicles (EVs) in xeno-free conditions, using CTS reagents of Thermo Fisher
000000000
Investigador responsável
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
 Thermo Fisher Scientific Inc.
Em curso
2019/07/01 - 2021/12/31 MSCellProduction: Production of Human Mesenchymal Stromal Cells in GMP compliant settings
POCI-01-0247-FEDER- 038313
Investigador
Instituto Superior Técnico, Universidade de Lisboa, Portugal

Biocant Associação de Transferência de Tecnologia, Portugal

CNC.IBILI, Portugal
Autoridade de Gestão do Programa Operacional Competitividade e Internacionalização
2018/11 - 2021/10 CELLS4ALL - Bioprocessing Strategies for high productivity in the Culture of Human Stem Cells in Stirred Tank Bioreactors and their downstream
H2020-INNOVOUCHER-2018-0039
Investigador responsável
European Commission
Em curso

Outro

Designação Financiadores
2021/09 - Atual Modulation of angiogenesis by extracellular vesicles from mesenchymal stromal cells using minicircle-derived RNAi technology
-
Investigador responsável
Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
 Universidade de Lisboa Instituto de Bioengenharia e Biociências
Em curso
Produções

Publicações

Artigo em conferência
  1. Mafalda S. Santos; Rachel Cordeiro; Carla S. Moura; Cláudia L. da Silva; Frederico Castelo Ferreira; João C. Silva; Marta S. Carvalho. "Decellularized Extracellular Matrix Polycaprolactone/Chitosan Composite Nanofibrous Scaffolds for Periodontal Tissue Engineering". 2023.
    10.3390/IOCN2023-14495
  2. Alexandra B. dos Santos; Cláudia L. da Silva; Marta S. Carvalho. "In Vitro Response of Dental Stem Cells on Decellularized Extracellular Matrix-Derived Hydrogels". 2022.
    10.3390/ASEC2022-13832
  3. Pereira, M.J.C.; Ramalhete, L.; Aleixo, S.; Da Silva, C.L.; Cabral, J.M.S.; Calado, C.R.C.; Fernandes-Platzgummer, A.. "Impact of the human mesenchymal stem cells donor on conditional medium composition". 2019.
    10.1109/ENBENG.2019.8692511
  4. Ulpiano, C.; Alves, C.A.P.; Silva-Santos, A.R.; Serra, J.; Da Silva, C.L.; Monteiro, G.A.. "RNAi as a tool to inhibit the angiogenic potential of human Mesenchymal Stem/Stromal Cells in malignancy". 2019.
    10.1109/ENBENG.2019.8692558
  5. Gracio, Patricia C.; Goncalves-Dias, Clara; Lopes-Coelho, Filipa; Monteiro, Emilia C.; Serpa, Jacinta; da Silva, Claudia L.; Pereira, Sofia A.. "Changes in N-acetyltransferase 8 in kidney tubular cell: injury, recovery and mesenchymal stromal cell-based therapy". 2019.
    10.1109/enbeng.2019.8692517
  6. Rosa, F.O.P.; Cunha, B.; Carmelo, J.G.; Fernandes-Platzgummer, A.; Da Silva, C.L.; Calado, C.R.C.. "Mid-infrared spectroscopy: A groundbreaking tool for monitoring mammalian cells processes". 2017.
    10.1109/ENBENG.2017.7889479
  7. Moura, C.S.; Da Silva, C.L.; Bártolo, P.J.; Ferreira, F.C.. "Combination of 3D extruded-based poly (e-caprolactone) scaffolds with mesenchymal stem/stromal cells: Strategy optimization". 2015.
    10.1016/j.proeng.2015.07.019
  8. Monteiro, Beatriz J. C.; Guerreiro, Joao D. T.; dos Santos, Francisco; Cabral, Joaquim S. M.; da Silva, Claudia Lobato; Ferreira, Frederico Castelo; IEEE. "Study of the Effec ts of Electrospun Poly(epsloncaprolactone)/Gelatin Matrices on Human Mesenchymal Stem Cell Culture". Lisboa, 2013.
  9. Oliveira, P.H.; Boura, J.S.; Abecasis, M.M.; Da Silva, C.L.; Cabral, J.M.S.. "An appraisal of genetic stability in human mesenchymal stem cells". 2011.
    10.1109/ENBENG.2011.6026040
  10. Fernandes, Tiago G.; Diogo, Maria Margarida; Fernandes-Platzgummer, Ana; da Silva, Claudia Lobato; Cabral, Joaquim M. S.; Fernandes, T.G.; Diogo, M.M.; et al. "Effect of hypoxia on proliferation and neural commitment of embryonic stem cells at different stages of pluripotency". 2011.
    10.1109/enbeng.2011.6026039
  11. Madeira, Catarina; Ribeiro, Sofia C.; Mendes, Rui; Pinheiro, Irina S. M.; da Silva, Claudia L.; Cabral, Joaquim M. S.. "Genetic engineering of stem cells by non-viral vectors". 2011.
    10.1109/enbeng.2011.6026044
Artigo em revista
  1. Hélder Bandarra-Tavares; Teresa Franchi-Mendes; Cristiana Ulpiano; Sara Morini; Navjot Kaur; Abigail Harris-Becker; Mohan C. Vemuri; et al. "Dual production of human mesenchymal stromal cells and derived extracellular vesicles in a dissolvable microcarrier-based stirred culture system". Cytotherapy (2024): https://doi.org/10.1016/j.jcyt.2024.03.001.
    10.1016/j.jcyt.2024.03.001
  2. Cláudia Raquel Marques; Jonas Campos; Belém Sampaio-Marques; Filipa Ferreira Antunes; Raquel Medina dos Santos Cunha; Deolinda Silva; Sandra Barata-Antunes; et al. "Secretome of bone marrow mesenchymal stromal cells cultured in a dynamic system induces neuroprotection and modulates microglial responsiveness in an a-synuclein overexpression rat model". Cytotherapy (2024): https://doi.org/10.1016/j.jcyt.2024.02.008.
    10.1016/j.jcyt.2024.02.008
  3. Ana Luísa Cartaxo; Ana Fernandes-Platzgummer; Carlos A.V. Rodrigues; Ana M. Melo; Katja Tecklenburg; Eva Margreiter; Richard M. Day; Cláudia L. da Silva; Joaquim M.S. Cabral. "Developing a Cell-Microcarrier Tissue-Engineered Product for Muscle Repair Using a Bioreactor System". Tissue Engineering Part C: Methods (2023): https://doi.org/10.1089/ten.tec.2023.0122.
    10.1089/ten.tec.2023.0122
  4. Teresa Franchi-Mendes; Marília Silva; Ana Luísa Cartaxo; Ana Fernandes-Platzgummer; Joaquim M. S. Cabral; Cláudia L. da Silva. "Bioprocessing Considerations towards the Manufacturing of Therapeutic Skeletal and Smooth Muscle Cells". Bioengineering (2023): https://doi.org/10.3390/bioengineering10091067.
    10.3390/bioengineering10091067
  5. Ana Fernandes-Platzgummer; Raquel Cunha; Sara Morini; Marta Carvalho; Juan Moreno-Cid; Carmen García; Joaquim M. S. Cabral; Cláudia L. da Silva. "Optimized operation of a controlled stirred tank reactor system for the production of mesenchymal stromal cells and their extracellular vesicles". Biotechnology and Bioengineering (2023): https://doi.org/10.1002/bit.28449.
    10.1002/bit.28449
  6. Laura Alves; Vanessa Machado; João Botelho; José João Mendes; Joaquim M. S. Cabral; Cláudia L. da Silva; Marta S. Carvalho. "Enhanced Proliferative and Osteogenic Potential of Periodontal Ligament Stromal Cells". Biomedicines (2023): https://doi.org/10.3390/biomedicines11051352.
    10.3390/biomedicines11051352
  7. Cláudia Raquel Marques; Miguel de Almeida Fuzeta; Raquel Medina dos Santos Cunha; Joana Pereira-Sousa; Deolinda Silva; Jonas Campos; Andreia Teixeira-Castro; et al. "Neurodifferentiation and Neuroprotection Potential of Mesenchymal Stromal Cell-Derived Secretome Produced in Different Dynamic Systems". Biomedicines (2023): https://doi.org/10.3390/biomedicines11051240.
    10.3390/biomedicines11051240
  8. Cristiana Ulpiano; Cláudia L. da Silva; Gabriel A. Monteiro. "Bioengineered Mesenchymal-Stromal-Cell-Derived Extracellular Vesicles as an Improved Drug Delivery System: Methods and Applications". Biomedicines (2023): https://doi.org/10.3390/biomedicines11041231.
    10.3390/biomedicines11041231
  9. André Branco; Ana L. Tiago; Paula Laranjeira; Maria C. Carreira; João C. Milhano; Francisco dos Santos; Joaquim M. S. Cabral; et al. "Hypothermic Preservation of Adipose-Derived Mesenchymal Stromal Cells as a Viable Solution for the Storage and Distribution of Cell Therapy Products". Bioengineering (2022): https://doi.org/10.3390/bioengineering9120805.
    10.3390/bioengineering9120805
  10. Miguel de Almeida Fuzeta; Pedro P. Gonçalves; Ana Fernandes-Platzgummer; Joaquim M. S. Cabral; Nuno Bernardes; Cláudia L. da Silva. "From Promise to Reality: Bioengineering Strategies to Enhance the Therapeutic Potential of Extracellular Vesicles". Bioengineering (2022): https://doi.org/10.3390/bioengineering9110675.
    10.3390/bioengineering9110675
  11. Cristiana Ulpiano; Cláudia L. da Silva; Gabriel A. Monteiro. "Mesenchymal Stromal Cells (MSCs): A Promising Tool for Cell-Based Angiogenic Therapy". Current Gene Therapy 21 (2021): https://doi.org/10.2174/1566523221666210917114353.
    10.2174/1566523221666210917114353
  12. Sara Bucar; André Dargen de Matos Branco; Márcia F. Mata; João Coutinho Milhano; Íris Caramalho; Joaquim M. S. Cabral; Ana Fernandes-Platzgummer; Cláudia L. da Silva. "Influence of the mesenchymal stromal cell source on the hematopoietic supportive capacity of umbilical cord blood-derived CD34+-enriched cells". Stem Cell Research & Therapy 12 1 (2021): https://doi.org/10.1186/s13287-021-02474-8.
    10.1186/s13287-021-02474-8
  13. Carvalho, Marta S.; Alves, Laura; Bogalho, Isabel; Cabral, Joaquim M. S.; da Silva, Cláudia L.. "Impact of Donor Age on the Osteogenic Supportive Capacity of Mesenchymal Stromal Cell-Derived Extracellular Matrix". Frontiers in Cell and Developmental Biology 9 (2021): http://dx.doi.org/10.3389/fcell.2021.747521.
    Acesso aberto • 10.3389/fcell.2021.747521
  14. Joana Serra; Cláudia P. A. Alves; Joaquim M. S. Cabral; Gabriel A. Monteiro; Cláudia L. Silva; Duarte Miguel F. Prazeres. "Minicircle-based expression of vascular endothelial growth factor in mesenchymal stromal cells from diverse human tissues". The Journal of Gene Medicine (2021): https://doi.org/10.1002/jgm.3342.
    10.1002/jgm.3342
  15. Marta Carvalho; Joaquim M.S. Cabral; Deepak Vashishth. "Bone Matrix Non-Collagenous Proteins in Tissue Engineering: Creating New Bone by Mimicking the Extracellular Matrix". Polymers (2021): https://www.mdpi.com/2073-4360/13/7/1095.
    10.3390/polym13071095
  16. Costa, Marta H. G.; Serra, Joana; McDevitt, Todd C.; Cabral, Joaquim M. S.; da Silva, Cláudia L.; Ferreira, Frederico Castelo. "Dimethyloxalylglycine, a small molecule, synergistically increases the homing and angiogenic properties of human mesenchymal stromal cells when cultured as 3D spheroids". Biotechnology Journal (2021): 2000389. http://dx.doi.org/10.1002/biot.202000389.
    10.1002/biot.202000389
  17. Pinto, Catarina I. G.; Bucar, Sara; Alves, Vítor; Fonseca, Alexandra; Abrunhosa, Antero J.; da Silva, Cláudia L.; Guerreiro, Joana F.; Mendes, Filipa. "Copper-64 Chloride Exhibits Therapeutic Potential in Three-Dimensional Cellular Models of Prostate Cancer". Frontiers in Molecular Biosciences 7 (2020): http://dx.doi.org/10.3389/fmolb.2020.609172.
    Acesso aberto • 10.3389/fmolb.2020.609172
  18. de Almeida Fuzeta, Miguel; Bernardes, Nuno; Oliveira, Filipa D.; Costa, Ana Catarina; Fernandes-Platzgummer, Ana; Farinha, José Paulo; Rodrigues, Carlos A. V.; et al. "Scalable Production of Human Mesenchymal Stromal Cell-Derived Extracellular Vesicles Under Serum-/Xeno-Free Conditions in a Microcarrier-Based Bioreactor Culture System". Frontiers in Cell and Developmental Biology 8 (2020): http://dx.doi.org/10.3389/fcell.2020.553444.
    Acesso aberto • 10.3389/fcell.2020.553444
  19. Branco, André; Bucar, Sara; Moura-Sampaio, Jorge; Lilaia, Carla; Cabral, Joaquim M. S.; Fernandes-Platzgummer, Ana; Lobato da Silva, Cláudia. "Tailored Cytokine Optimization for ex vivo Culture Platforms Targeting the Expansion of Human Hematopoietic Stem/Progenitor Cells". Frontiers in Bioengineering and Biotechnology 8 (2020): http://dx.doi.org/10.3389/fbioe.2020.573282.
    Acesso aberto • 10.3389/fbioe.2020.573282 • Editor
  20. Silva, Marília; Monteiro, Gabriel Amaro; Fialho, Arsenio M.; Bernardes, Nuno; da Silva, Cláudia Lobato. "Conditioned Medium From Azurin-Expressing Human Mesenchymal Stromal Cells Demonstrates Antitumor Activity Against Breast and Lung Cancer Cell Lines". Frontiers in Cell and Developmental Biology 8 (2020): http://dx.doi.org/10.3389/fcell.2020.00471.
    10.3389/fcell.2020.00471
  21. Azevedo, Rita I.; Minskaia, Ekaterina; Fernandes-Platzgummer, Ana; Vieira, Ana I. S.; da Silva, Cláudia L.; Cabral, Joaquim M. S.; Lacerda, João F.. "Mesenchymal stromal cells induce regulatory T cells via epigenetic conversion of human conventional CD4 T cells in vitro". STEM CELLS 38 8 (2020): 1007-1019. http://dx.doi.org/10.1002/stem.3185.
    10.1002/stem.3185
  22. Moreira, Francisco; Mizukami, Amanda; de Souza, Lucas Eduardo Botelho; Cabral, Joaquim M. S.; da Silva, Cláudia L.; Covas, Dimas T.; Swiech, Kamilla. "Successful Use of Human AB Serum to Support the Expansion of Adipose Tissue-Derived Mesenchymal Stem/Stromal Cell in a Microcarrier-Based Platform". Frontiers in Bioengineering and Biotechnology 8 (2020): http://dx.doi.org/10.3389/fbioe.2020.00307.
    Acesso aberto • 10.3389/fbioe.2020.00307
  23. Carvalho, Marta S.; Silva, João C.; Hoff, Christopher M.; Cabral, Joaquim M. S.; Linhardt, Robert J.; Silva, Cláudia L.; Vashishth, Deepak. "Loss and rescue of osteocalcin and osteopontin modulate osteogenic and angiogenic features of mesenchymal stem/stromal cells". Journal of Cellular Physiology 235 10 (2020): 7496-7515. http://dx.doi.org/10.1002/jcp.29653.
    10.1002/jcp.29653
  24. Moura, Carla Sofia; Silva, João Carlos; Faria, Sofia; Fernandes, Paulo Rui; da Silva, Cláudia Lobato; Cabral, Joaquim Manuel Sampaio; Linhardt, Robert; Bártolo, Paulo Jorge; Ferreira, Frederico Castelo. "Chondrogenic differentiation of mesenchymal stem/stromal cells on 3D porous poly (e-caprolactone) scaffolds: Effects of material alkaline treatment and chondroitin sulfate supplementation". Journal of Bioscience and Bioengineering (2020): http://dx.doi.org/10.1016/j.jbiosc.2020.01.004.
    10.1016/j.jbiosc.2020.01.004
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  74. Correia, V.G.; Bonifácio, V.D.; Raje, V.P.; Casimiro, T.; Moutinho, G.; da Silva, C.L.; Pinho, M.G.; Aguiar-Ricardo, A.. "Oxazoline-Based Antimicrobial Oligomers: Synthesis by CROP Using Supercritical CO 2". Macromolecular Bioscience 11 8 (2011): 1128-1137. http://www.scopus.com/inward/record.url?eid=2-s2.0-79961093501&partnerID=MN8TOARS.
    10.1002/mabi.201100126
  75. Loureiro, J.; Andrade, P.Z.; Cardoso, S.; Da Silva, C.L.; Cabral, J.M.; Freitas, P.P.. "Magnetoresistive chip cytometer". Lab on a Chip - Miniaturisation for Chemistry and Biology 11 13 (2011): 2255-2261. http://www.scopus.com/inward/record.url?eid=2-s2.0-79958807569&partnerID=MN8TOARS.
    10.1039/c0lc00324g
  76. Rodrigues, C.A.V.; Fernandes, T.G.; Diogo, M.M.; da Silva, C.L.; Cabral, J.M.S.. "Stem cell cultivation in bioreactors". Biotechnology Advances 29 6 (2011): 815-829. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053449223&partnerID=MN8TOARS.
    10.1016/j.biotechadv.2011.06.009
  77. Rodrigues, C.A.V.; Diogo, M.M.; Da Silva, C.L.; Cabral, J.M.S.. "Design and operation of bioreactor systems for the expansion of pluripotent stem cell-derived neural stem cells". 1st Portuguese Meeting in Biomedical Engineering, ENBENG 2011 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-80053983127&partnerID=MN8TOARS.
    10.1109/ENBENG.2011.6026041
  78. Madeira, C.; Ribeiro, S.C.; Pinheiro, I.S.M.; Martins, S.A.M.; Andrade, P.Z.; da Silva, C.L.; Cabral, J.M.S.. "Gene delivery to human bone marrow mesenchymal stem cells by microporation". Journal of Biotechnology 151 1 (2011): 130-136. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650679233&partnerID=MN8TOARS.
    10.1016/j.jbiotec.2010.11.002
  79. Fernandes-Platzgummer, Ana; Diogo, Maria M.; Baptista, Ricardo P.; da Silva, Claudia Lobato; Cabral, Joaquim M. S.. "Scale-Up of Mouse Embryonic Stem Cell Expansion in Stirred Bioreactors". Biotechnology Progress 27 5 (2011): 1421-1432.
    10.1002/btpr.658
  80. Rodrigues, C.A.V.; Diogo, M.M.; Da Silva, C.L.; Cabral, J.M.S.. "Microcarrier expansion of mouse embryonic stem cell-derived neural stem cells in stirred bioreactors". Biotechnology and Applied Biochemistry 58 4 (2011): 231-242. http://www.scopus.com/inward/record.url?eid=2-s2.0-80051763713&partnerID=MN8TOARS.
    10.1002/bab.37
  81. Andrade, Pedro Z.; da Silva, Claudia Lobato; dos Santos, Francisco; Almeida-Porada, Graca; Cabral, Joaquim M. S.. "Initial CD34(+) Cell-Enrichment of Cord Blood Determines Hematopoietic Stem/Progenitor Cell Yield Upon Ex Vivo Expansion". Journal of Cellular Biochemistry 112 7 (2011): 1822-1831.
    10.1002/jcb.23099
  82. Loureiro, J.; Andrade, P.Z.; Cardoso, S.; Da Silva, C.L.; Cabral, J.M.; Freitas, P.P.. "Spintronic chip cytometer". Journal of Applied Physics 109 7 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-79955422738&partnerID=MN8TOARS.
    10.1063/1.3559503
  83. Costa, E.; De-Carvalho, J.; Casimiro, T.; Da Silva, C.L.; Cidade, M.T.; Aguiar-Ricardo, A.. "Tailoring thermoresponsive microbeads in supercritical carbon dioxide for biomedical applications". Journal of Supercritical Fluids 56 3 (2011): 292-298. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952120733&partnerID=MN8TOARS.
    10.1016/j.supflu.2010.10.039
  84. dos Santos, Francisco; Andrade, Pedro Z.; Abecasis, Manuel M.; Gimble, Jeffrey M.; Chase, Lucas G.; Campbell, Andrew M.; Boucher, Shayne; et al. "Toward a Clinical-Grade Expansion of Mesenchymal Stem Cells from Human Sources: A Microcarrier-Based Culture System Under Xeno-Free Conditions". Tissue Engineering Part C-Methods 17 12 (2011): 1201-1210.
    10.1089/ten.tec.2011.0255
  85. Andrade, Pedro Z.; dos Santos, Francisco; Almeida-Porada, Graca; da Silva, Claudia Lobato; Cabral, Joaquim M. S.. "Systematic delineation of optimal cytokine concentrations to expand hematopoietic stem/progenitor cells in co-culture with mesenchymal stem cells". Molecular Biosystems 6 7 (2010): 1207-1215.
    10.1039/b922637k
  86. Da Silva, C.L.; Madeira, C.; Mendes, R.D.; Ribeiro, S.C.; Boura, J.S.; Aires-Barros, M.R.; Cabral, J.M.S.. "Nonviral gene delivery to mesenchymal stem cells using cationic liposomes for gene and cell therapy". Journal of Biomedicine and Biotechnology 2010 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77955411071&partnerID=MN8TOARS.
    10.1155/2010/735349
  87. Fernandes, T.G.; Diogo, M.M.; Fernandes-Platzgummer, A.; da Silva, C.L.; Cabral, J.M.S.. "Different stages of pluripotency determine distinct patterns of proliferation, metabolism, and lineage commitment of embryonic stem cells under hypoxia". Stem Cell Research 5 1 (2010): 76-89. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953286613&partnerID=MN8TOARS.
    10.1016/j.scr.2010.04.003
  88. Ribeiro, S. C.; Mendes, R.; Madeira, C.; Monteiro, G. A.; da Silva, C. L.; Cabral, J. M. S.. "A Quantitative Method to Evaluate Mesenchymal Stem Cell Lipofection Using Real-Time PCR". Biotechnology Progress 26 5 (2010): 1501-1504.
    10.1002/btpr.451
  89. Rodrigues, C.A.V.; Diogo, M.M.; Da Silva, C.L.; Cabral, J.M.S.. "Hypoxia enhances proliferation of mouse embryonic stem cell-derived neural stem cells". Biotechnology and Bioengineering 106 2 (2010): 260-270. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953062351&partnerID=MN8TOARS.
    10.1002/bit.22648
  90. Eibes, G.; dos Santos, F.; Andrade, P.Z.; Boura, J.S.; Abecasis, M.M.A.; da Silva, C.L.; Cabral, J.M.S.. "Maximizing the ex vivo expansion of human mesenchymal stem cells using a microcarrier-based stirred culture system". Journal of Biotechnology 146 4 (2010): 194-197. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950457742&partnerID=MN8TOARS.
    10.1016/j.jbiotec.2010.02.015
  91. Dos Santos, F.; Andrade, P.Z.; Boura, J.S.; Abecasis, M.M.; Da Silva, C.L.; Cabral, J.M.S.. "Ex vivo expansion of human mesenchymal stem cells: A more effective cell proliferation kinetics and metabolism under hypoxia". Journal of Cellular Physiology 223 1 (2010): 27-35. http://www.scopus.com/inward/record.url?eid=2-s2.0-75749145078&partnerID=MN8TOARS.
    10.1002/jcp.21987
  92. Da Silva, C.L.; Gonçalves, R.; Dos Santos, F.; Andrade, P.Z.; Almeida-Porada, G.; Cabral, J.M.S.. "Dynamic cell-cell interactions between cord blood haematopoietic progenitors and the cellular niche are essential for the expansion of CD34 +, CD34+CD38- and early lymphoid CD7 + cells". Journal of Tissue Engineering and Regenerative Medicine 4 2 (2010): 149-158. http://www.scopus.com/inward/record.url?eid=2-s2.0-77649221153&partnerID=MN8TOARS.
    10.1002/term.226
  93. Serro, A.P.; Completo, C.; Colaço, R.; dos Santos, F.; da Silva, C.L.; Cabral, J.M.S.; Araújo, H.; Pires, E.; Saramago, B.. "A comparative study of titanium nitrides, TiN, TiNbN and TiCN, as coatings for biomedical applications". Surface and Coatings Technology 203 24 (2009): 3701-3707. http://www.scopus.com/inward/record.url?eid=2-s2.0-67650108479&partnerID=MN8TOARS.
    10.1016/j.surfcoat.2009.06.010
  94. Da Silva, C.L.; Gonçalves, R.; Porada, C.D.; Ascensão, J.L.; Zanjani, E.D.; Cabral, J.M.S.; Almeida-Porada, G.. "Differences amid bone marrow and cord blood hematopoietic stem/progenitor cell division kinetics". Journal of Cellular Physiology 220 1 (2009): 102-111. http://www.scopus.com/inward/record.url?eid=2-s2.0-65549085564&partnerID=MN8TOARS.
    10.1002/jcp.21736
  95. Temtem, M.; Silva, L.M.C.; Andrade, P.Z.; dos Santos, F.; da Silva, C.L.; Cabral, J.M.S.; Abecasis, M.M.; Aguiar-Ricardo, A.. "Supercritical CO2 generating chitosan devices with controlled morphology. Potential application for drug delivery and mesenchymal stem cell culture". Journal of Supercritical Fluids 48 3 (2009): 269-277. http://www.scopus.com/inward/record.url?eid=2-s2.0-61549084665&partnerID=MN8TOARS.
    10.1016/j.supflu.2008.10.020
  96. Fernandes, T.G.; Fernandes-Platzgummer, A.M.; da Silva, C.L.; Diogo, M.M.; Cabral, J.M.S.. "Kinetic and metabolic analysis of mouse embryonic stem cell expansion under serum-free conditions". Biotechnology Letters 32 1 (2009): 171-179. http://www.scopus.com/inward/record.url?eid=2-s2.0-72249097517&partnerID=MN8TOARS.
    10.1007/s10529-009-0108-0
  97. Fernandes, A.M.; Fernandes, T.G.; Diogo, M.M.; da Silva, C.L.; Henrique, D.; Cabral, J.M.S.. "Mouse embryonic stem cell expansion in a microcarrier-based stirred culture system". Journal of Biotechnology 132 2 (2007): 227-236. http://www.scopus.com/inward/record.url?eid=2-s2.0-35348996645&partnerID=MN8TOARS.
    10.1016/j.jbiotec.2007.05.031
  98. Da Silva, C.L.; Gonçalves, R.; Crapnell, K.B.; Cabral, J.M.S.; Zanjani, E.D.; Almeida-Porada, G.. "A human stromal-based serum-free culture system supports the ex vivo expansion/maintenance of bone marrow and cord blood hematopoietic stem/progenitor cells". Experimental Hematology 33 7 (2005): 828-835. http://www.scopus.com/inward/record.url?eid=2-s2.0-20444500801&partnerID=MN8TOARS.
    10.1016/j.exphem.2005.03.017
Capítulo de livro
  1. Fernandes-Platzgummer, Ana; Andrade, Pedro Z.; Cabral, Joaquim M. S.; da Silva, Cláudia Lobato. "Scalable Manufacturing of Human Hematopoietic Stem/Progenitor Cells Exploiting a Co-culture Platform with Mesenchymal Stromal Cells". In Stem Cells and Good Manufacturing Practices, 107-120. Springer US, 2020.
    10.1007/7651_2020_289
  2. de Almeida Fuzeta, Miguel; de Matos Branco, André Dargen; Fernandes-Platzgummer, Ana; da Silva, Cláudia Lobato; Cabral, Joaquim M. S.. "Addressing the Manufacturing Challenges of Cell-Based Therapies". In Advances in Biochemical Engineering/Biotechnology. Springer Berlin Heidelberg, 2019.
    Publicado • 10.1007/10_2019_118
  3. Silva, J.C.; Carvalho, M.S.; Xia, K.; Cabral, J.M.S.; da Silva, C.L.; Ferreira, F.C.; Vashishth, D.; et al. "Glycosaminoglycan disaccharide compositional analysis of cell-derived extracellular matrices using liquid chromatography-tandem mass spectrometry". In Cell-derived Matrices - Part A, 85-106. Elsevier, 2019.
    10.1016/bs.mcb.2019.11.017
  4. Pinto, D.S.; Da Silva, C.L.; Cabral, J.M.S.. "Scalable expansion of mesenchymal stem/stromal cells in bioreactors: A focus on hydrodynamic characterization". 537-550. 2019.
  5. da Silva CL. "Gene delivery as a tool to improve the therapeutic features of mesenchymal stromal cells: methods and applications". In Gene delivery as a tool to improve the therapeutic features of mesenchymal stromal cells: methods and applications. Nova Science Publisher, 2019.
    Publicado
  6. Costa, Marta H. G.; Monteiro, Tiago S.; Cardoso, Susana; Cabral, Joaquim M. S.; Ferreira, Frederico Castelo; da Silva, Cláudia L.. "Three-Dimensional Co-culture of Human Hematopoietic Stem/Progenitor Cells and Mesenchymal Stem/Stromal Cells in a Biomimetic Hematopoietic Niche Microenvironment". In Methods in Molecular Biology, 101-119. Springer New York, 2018.
    10.1007/7651_2018_181
  7. Fernandes-Platzgummer, Ana; Badenes, Sara M.; da Silva, Cláudia L.; Cabral, Joaquim M. S.. "Bioreactors for Stem Cell and Mammalian Cell Cultivation". In Bioprocessing Technology for Production of Biopharmaceuticals and Bioproducts, 131-173. John Wiley & Sons, Inc., 2018.
    Publicado • 10.1002/9781119378341.ch4
  8. Costa, Marta H.G.. "Bioreactors for the Cultivation of Hematopoietic Stem and Progenitor Cells". In Bioreactors for Stem Cell Expansion and Differentiation, 165-200. CRC Press, 2018.
    Publicado • 10.1201/9780429453144-7
  9. Fernandes-Platzgummer, Ana; Carmelo, Joana G; da Silva, Claudia Lobato; Cabral, Joaquim M S; Carmelo, Joana G.; da Silva, Cláudia Lobato; Cabral, Joaquim M. S.. "Clinical-Grade Manufacturing of Therapeutic Human Mesenchymal Stem/Stromal Cells in Microcarrier-Based Culture Systems.". In Methods in molecular biology (Clifton, N.J.), 375-88. Springer New York, 2016.
    10.1007/978-1-4939-3584-0_22
  10. Badenes, S.M.; Fernandes-Platzgummer, A.; Rodrigues, C.A.V.; Diogo, M.M.; Da Silva, C.L.; Cabral, J.M.S.. "Microcarrier Culture Systems for Stem Cell Manufacturing". 77-104. 2016.
  11. Carmelo, Joana G; Fernandes-Platzgummer, Ana; Cabral, Joaquim M S; da Silva, Claudia Lobato. "Scalable ex vivo expansion of human mesenchymal stem/stromal cells in microcarrier-based stirred culture systems.". In Methods in molecular biology (Clifton, N.J.), 147-59. 2015.
    10.1007/7651_2014_100
  12. Moura, C; Biscaia, S; Viana, T; Bártolo, P; da Silva, C; C., J; Moura, C. S.; et al. "Adhesion, proliferation and distribution of human mesenchymal stem/stromal cells (MSCs) in Poly(_-caprolactone) (PCL) scaffolds with different pore sizes". In High Value Manufacturing: Advanced Research in Virtual and Rapid Prototyping, 195-198. CRC Press, 2015.
    10.1201/b15961-36
  13. da Silva CL. "Bioreactors for Stem Cell Expansion and Differentiation". In Handbook of Biomedical Engineering. Elsevier, 2015.
  14. Diogo, Maria Margarida; da Silva, Cláudia Lobato; Cabral, Joaquim M. S.. "Separation Technologies for Stem Cell Bioprocessing". In Stem Cells and Cell Therapy, 157-181. Springer Netherlands, 2014.
    10.1007/978-94-007-7196-3_7
  15. Santos, F. Dos; Andrade, P. Z.; da Silva, C. L.; Cabral, J. M. S.; Dos Santos, F.; Andrade, P.Z.; da Silva, C.L.; Cabral, J.M.S.. "Scaling-up Ex Vivo Expansion of Mesenchymal Stem/Stromal Cells for Cellular Therapies". In Mesenchymal Stem Cell Therapy, 1-14. Humana Press, 2012.
    10.1007/978-1-62703-200-1_1
  16. Madeira, C.; Dos Santos, F.; Andrade, P.Z.; Da Silva, C.L.; Cabral, J.M.S.; Madeira, Catarina; dos Santos, Francisco; et al. "Mesenchymal stem cells for cellular therapies". In Stem Cells and Cancer Stem Cells,Volume 3, 179-187. Springer Netherlands, 2012.
  17. da Silva CL. "Bioreactors for Stem Cell Expansion and Differentiation". In Stem Cell Engineering: Principles and Practices, 1-28. CRC Press, 2012.
  18. Fernandes-Platzgummer, A.; Diogo, M.M.; Da Silva, C.L.; Cabral, J.M.S.. "Large-scale expansion of mouse embryonic stem cells on microcarriers". In Methods in Molecular Biology, 121-134. 2011.
    10.1007/978-1-60761-962-8_8
  19. dos Santos, F.; Andrade, P.Z.; Eibes, G.; da Silva, C.L.; Cabral, J.M.. "Ex vivo expansion of human mesenchymal stem cells on microcarriers.". In Methods in molecular biology (Clifton, N.J.), 189-198. 2011.
    10.1007/978-1-60761-999-4_15
  20. da Silva CL. "Biorreactores Para Cultura De Células Animais". In Reactores Biológicos, 455-483. LIDEL, 2006.
  21. Lobato Da Silva, C.; Gonçalves, R.; Lemos, F.; Lemos, M.A.N.D.A.; Zanjani, E.D.; Almeida-Porada, G.; Cabral, J.M.S.. "Live Catalysis". In Principles and Methods for Accelerated Catalyst Design and Testing, 439-446. Springer Netherlands, 2002.
    10.1007/978-94-010-0554-8_32
Edição de número de revista
  1. Joaquim M.S. Cabral; Maria Margarida Diogo. "Stem Cell Bioprocessing and Manufacturing". Bioengineering (2020): https://www.mdpi.com/2306-5354/7/3/84.
    10.3390/bioengineering7030084 • Co-editor
  2. da Silva CL. "Cell Culture Technologies for Protein- and Cell-Based Therapies". Frontiers in Bioengineering and Biotechnology (2019):
    Co-editor
Livro
  1. da Silva CL. Stem Cell Manufacturing. Elsevier. 2016.
    10.1016/c2011-0-05619-3 • Editor
Resumo em conferência
  1. Mizukami, A.; Neto, M. S.; Moreira, F.; Fernandes-Platzgummer, A.; Huang, Y.; Milligan, W.; Cabral, J. M.; et al. "EFFICIENT CLINICAL-SCALE EXPANSION OF ADIPOSE TISSUE DERIVED MESENCHYMAL STEM/SIROMAL CELLS IN A CLOSED AND AUTOMATED HOLLOW-FIBER BIOREACTOR UNDER XENO-FREE CULTURE CONDITIONS". 2017.
  2. Source, A.; Fernandes-Platzgummer, A.; Moreira, F.; Liu, S.; Ku, C.; Huang, Y.; Milligan, W.; et al. "A HUMAN PLATELET LYSATE-BASED CULTURE SUPPLEMENT FOR THE SUCCESSFUL ISOLATION AND SCALABLE EXPANSION OF UMBILICAL CORD MATRIX-DERIVED MESENCHYMAL STEM/STROMAL CELLS". 2016.
  3. Simoes, I. N.; Vale, P.; Cabral, J. M.; da Silva, C. L.; Baptista, P. M.; Eberli, D.. "Decellularized Sphincter Extracellular Matrix for Skeletal Muscle Restoration". 2015.
  4. Neves Simoes, I.; Vale, P.; Soker, S.; Atala, A.; Noiva, R.; Carrapico, B.; Peleteiro, C.; et al. "Urinary rhabdosphincter bioengineering - a decellularized matrix for modeling stress urinary incontinence in vitro". 2014.
  5. Fiarresga, A.; Lobato Da Silva, C.; Cavaco-Goncalves, S.; Selas, M.; Simoes, I.; Oliveira, E.; Carrapico, B.; et al. "Safety of intracoronary delivery of mesenchymal/stromal stem cells: insights from coronary microcirculation invasive assessment". 2014.
    10.1093/cvr/cvu091.42
  6. da Silva, C. L.; Andrade, P. Z.; Soure, A. M.; Santos, F. D.; Almeida-Porada, G.; Cabral, J. S.. "STEM CELL ENGINEERING TOWARDS THE OPTIMIZATION OF THE EX-VIVO EXPANSION OF HUMAN HEMATOPOIETIC STEM/PROGENITOR CELLS FOR CELLULAR THERAPIES". 2014.
  7. da Silva, C. L.; Carmelo, J. G.; Fernandes-Platzgummer, A.; Weber, J. L.; Bear, M.; Hervy, M.; Diogo, M. M.; et al. "SCALABLE PRODUCTION OF HUMAN MESENCHYMAL STEM/STROMAL CELLS IN MICROCARRIER-BASED CULTURE SYSTEMS". 2014.
  8. dos Santos, Francisco; Andrade, Pedro Z.; Abecasis, Manuel M.; Gimble, Jeffrey; Campbell, Andrew; Boucher, Shayne; Roos, Eric; et al. "Scalable expansion of human mesenchymal stem cells using a microcarrier-based system under serum-free and xeno-free conditions". Trabalho apresentado em ACS Meeting, 2012.
  9. Andrade, Pedro Z.; dos Santos, Francisco; Almeida-Porada, Graca; da Silva, Claudia Lobato; Cabral, Joaquim M. S.. "Towards optimal culture conditions for the ex-vivo expansion of umbilical cord blood hematopoietic stem/progenitor cells for cell therapy". Trabalho apresentado em American Chemical Society, 2012.
  10. Da Silva, C.L.; Andrade, P.Z.; Dos Santos, F.; Cabral, J.M.S.. "Ex-vivo expansion of hematopoietic stem cells from umbilical cord blood". Trabalho apresentado em 1st IEEE Portuguese, 2011.
    10.1109/ENBENG.2011.6026052
  11. Madeira, C.; Ribeiro, S.C.; Mendes, R.; Pinheiro, I.S.M.; Da Silva, C.L.; Cabral, J.M.S.. "Genetic engineering of stem cells by non-viral vectors". Trabalho apresentado em 1st Portuguese Meeting in Biomedical Engineering, ENBENG 2011, 2011.
    10.1109/ENBENG.2011.6026044
Tese / Dissertação
  1. da Silva CL. "A human stromal-based serum-free culture system for the ex-vivo expansion/maintenance of hematopoietic stem/progenitor cells". Doutoramento, Instituto Superior Técnico, Universidade Técnica de Lisboa, 2006.

Propriedade Intelectual

Patente
  1. da Silva CL. 2013. "Process for ex vivo expansion of stem cells in a bioreactor". Portugal.
    Concedida/Emitida
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2022/11/25 Mesenchymal Stromal Cell-based Therapy for Complex Crohn´s Perianal Fistulas - State of the art XXXI Congresso Nacional de Coloproctologia
Portuguese Society of Coloproctology (Porto, Portugal)
2022/06 Innovating the Manufacturing of Human Mesenchymal Stromal Cells (MSC) and MSC-derived Products through Bioengineering 27th ESACT Meeting
European Society for Animal Cell Technology (Lisboa, Portugal)
2022/03/22 Bioreactors for Regenerative Medicine CHI Bioprocessing Summit Europe
CHI Cambridge Healthtech Institute's (Barcelona, Espanha)
2022/03/04 Innovating the manufacturing of stem cell-based therapies Stem Cells Talks
TAKEDA (Lisboa, Portugal)
2021/10/06 Scalable Manufacturing of Stem Cell-based Therapies
Faculty of Pharmacy Universidade de Lisboa (Lisboa, Portugal)
2021/05 Scalable Manufacturing of Stem Cell-based Therapies 2º Encontro Advanced Therapy Medicinal Products (ATMPs)
SPFCS - Sociedade Portuguesa de Farmacêuticos dos Cuidados de Saúde (Lisboa, Portugal)
2020/05/28 Scalable manufacturing of MSC in three different bioreactor systems using hPL supplements” (virtual presentation) International Society of Cellular Therapy (ISCT) Annual Meeting (virtual format due to Covid19 outbreak)
(Paris, França)
2020/05/26 Innovating the Manufacturing of Human Mesenchymal Stromal Cells (MSC) and MSC-derived Products through Bioengineering (postponed due to Covid19 Oubreak) EU 2020 - TERMIS (postponed due to COVID outbreak)
TERMIS-EU Chapter (Manchester, Reino Unido)
2019/10 Stem Cells and Future in Clinical Practice Gastro Expert Meeting’19 (3rd Edition)
Astrazeneca (Porto, Portugal)
2018/07 Addressing the Manufacturing Challenges of Stem Cell-based Therapies through Bioengineering Encontro Ciência 2018, Encontro com a Ciência e Tecnologia em Portugal
Fundação para a Ciência e Tecnologia
2018/04 Addressing the Manufacturing Challenges of Stem Cell-based Therapies through Bioengineering University College London Stem Cell Research Symposium, DISCOVERIES CTR
University College London (London, Reino Unido)
2018 Addressing the Manufacturing Challenges of Stem Cell-based Therapies through Bioengineering June Seminars @ CEDOC Chronic Diseases
Nova Medical School, Lisboa (Lisboa, Portugal)
2017/12 Addressing the Manufacturing Challenges of Stem Cell-based Therapies through Bioengineering MICROBIOTEC17, Congress of Microbiology and Biotechnology
(Porto, Portugal)
2015/01 Scalable production of human mesenchymal stem/stromal cells in microcarrier-based stirred culture systems Scale-Up and Manufacturing of Cell-Based Therapies IV, San Diego
ECI (San Diego, Estados Unidos)
2015 Cardiac Regeneration Recent Advances ACS Master Class 2015 by Astrazeneca
Astrazeneca (lisboa, Portugal)
2014/12 Scalable Production of Human Stem/Progenitor Cells in Bioreactor Systems (virtual presentation) 2nd Annual 24 Hours of Stem Cells Virtual Meeting
Life Technologies (Estados Unidos)
2014/12 Ex-vivo Expansion of Human Stem/Progenitor Cells for Cellular Therapies IMM Monday Lecture
IMM-Instituto de Medicina Molecular (Lisboa, Portugal)
2014 Stem Cell Bioengineering Strategies in Regenerative Medicine 4th Advanced Course on Regenerative Medicine
Instituto Politécnico de Leiria (Marinha Grandes, Portugal)
2014 Stem Cell and Regenerative Therapy In Heart Disease 4th Challenges in Cardiology
Doctor João Morais (Cardiologist) (Leiria, Portugal)
2014 Stem Cell Bioengineering Strategies towards Cell-based Therapies for Myocardial Regeneration Tomorrow’s Medicine is Now, by Astrazeneca
Astrazeneca (Lisboa, Portugal)
2013/12 Scalable production of human stem/progenitor cells in microcarrier-based culture systems Cell Therapy Manufacturing, Brussels
(Brussels, Bélgica)
2013/07 Mesenchymal Stem/Stromal Cells for Myocardial Regeneration: autologous versus allogeneic therapies 4th Santa Marta Summer Meeting
Marco Costa (Case Western Reserve University, USA) & Rui Cruz Ferreira (Hospital Santa Marta, Lisboa) (lisboa, Portugal)
2012/11 Células Estaminais e Cartilagem 4th workshop on Articular Cartilage
GECA - Grupo de Estuda da Cartilagem - Prevenção e Tratamento da Artrose (lisboa, Portugal)
2012/09 Bioengineering Approaches for the Optimization of the Ex-vivo Expansion of Hematopoietic Stem/Progenitor Cells for Cell Therapy ESBES - 9th European Symposium on Biochemical Engineering Science
(Istambul, Turquia)
2012/01 Scalable Expansion Of Human Mesenchymal Stem Cells Using A Microcarrier-Based System Under Serum-Free And Xeno-Free Conditions Scale-Up and Manufacturing of Cell-Based Therapies
ECI (san diego, Estados Unidos)
2009 …E A Longa Viagem Continua – Entramos No Mundo Das Células Estaminais II Congresso Científico da Associação de Estudantes da Faculdade de Farmácia da Universidade de Lisboa
Associação de Estudantes da Faculdade de Farmácia da Universidade de Lisboa (Lisboa, Portugal)
2008 Maximization Of The Ex-Vivo Expansion Of Human Hematopoietic Stem/Progenitor Cells By Direct Contact Culture With Mesenchymal Stem Cells First International Conference on Stem Cell Engineering
Society for Biological Engineering (San Diego, Estados Unidos)
2008 Mouse embryonic stem cell expansion in a microcarrier-based stirred culture system Annual TERMIS - EU Meeting
TERMIS EU (Porto, Portugal)
2008 Ex-vivo Expansion of Human Hematopoietic Stem/Progenitor Cells in a Human Stromal-based Culture System Lectures on Modelling Cancer Growth and Treatments
Prof. Adélia Sequeira (Instituto Superior Técnico) (Estoril, Portugal)
2008 Terapia Celular com Células Estaminais Mesenquimatosas 2º Encontro Ciência em Portugal – Ciência 2008
Fundação para a Ciência e Tecnologia (Lisboa, Portugal)
2008 Bioengenharia de Células Estaminais Colóquio da Faculdade de Engenharia, Universidade Católica Portuguesa
Faculdade de Engenharia, Universidade Católica Portuguesa (Prof. Cecília Calado) (Sintra, Portugal)
2007/08 Ex-vivo Expansion of Human Hematopoietic Stem/Progenitor Cells in a Human Stromal-based Culture System 234th National Meeting & Exposition, American Chemical Society
ACS (Boston, Estados Unidos)
2007 Bioengenharia de Células Estaminais 1º Encontro Ciência em Portugal – Ciência 2007
Fundação para a Ciência e Tecnologia (Lisboa, Portugal)
2007 Defining Culture Conditions to Maximize the Ex-Vivo Expansion of Human Umbilical Cord Blood (CB) Hematopoietic Stem/Progenitor Cells: How to Start? (Awarded Best Oral Presentation in Cell and Tissue Culture Science and Engineering) Congresso Nacional de Microbiologia, Biotecnologia e Genética, MICROBIOTEC’2007
(Lisboa, Portugal)
2006 Ex-vivo Expansion And Differentiation Of Human Hematopoietic Stem Cells In Stromal-Based Culture Systems 3rd International Meeting on “Medical Engineering and Therapy"
(Nancy, França)
2006 Ex-vivo Expansion and Differentiation of Human Hematopoietic Stem Cells in Stromal-Based Culture Systems 6th Advanced Course on Applied Biochemistry “Bioengenharia dos Tecidos e Reologia”
Faculdade de Medicina, Universidade de Lisboa (Lisboa, Portugal)
2005/05 Ex-vivo Expansion of Human Hematopoietic Stem Cells in Stromal-Based Culture Systems 1st Annual International Meeting of the Portuguese Society for Stem Cells and Cellular Therapies (SPCE-TC)
Portuguese Society for Stem Cells and Cellular Therapies (SPCE-TC) (Funchal, Portugal)
2004 Ex-Vivo Expansion/Maintenance and Differentiation of Human Hematopoietic Stem Cells in Stroma-Based Culture Systems European Symposium on Biochemical Engineering Science – 5
European Symposium on Biochemical Engineering Science (Stutgart, Alemanha)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2024/02 - Atual Scalable Production of Extracellular Vesicles Derived from Mesenchymal Stromal Cell Aggregates for Cancer Therapy: In Vitro Screening in 3D Heterotypic Tumor Spheroids
Coorientador
 Biotecnologia e Biociências (Doutoramento)
Instituto Superior Técnico, Universidade de Lisboa, Portugal
2023/10 - Atual Development of a bio-inspired 3D co-culture system to expand autologous hematopoietic stem/progenitor cells in the context of acquired aplastic anemia
Orientador
 Bioengenharia (Doutoramento)
Instituto Superior Técnico, Universidade de Lisboa, Portugal
2023/09 - Atual Impact of the Secretome of Induced Mesenchymal Stem Cells as a Therapeutic Option for the Treatment of Parkinson's Disease
Coorientador
 Health Sciences (Doutoramento)
Universidade do Minho Escola de Ciências da Saúde, Portugal
2023/01 - Atual GMP-compliant manufacturing of mesenchymal stromal cells-derived extracellular vesicles towards the development of a cell-free therapy for autoimmune diseases
Coorientador
 Bioengenharia (Doutoramento)
Instituto Superior Técnico, Universidade de Lisboa, Portugal
2022/03 - Atual Scalable expansion of smooth muscle cells and urothelial cells for bladder tissue engineering
Orientador
 Post-doctoral research in Stem Cell Engineering (Outra)
Instituto Superior Técnico, Universidade de Lisboa, Portugal
2020/01 - Atual The role of Tu-stroma a long non-coding RNA in the modification of tumour microenvironment in ovarian cancer
Coorientador
 Biotecnologia e Biociências (Doutoramento)
Instituto Superior Técnico, Universidade de Lisboa, Portugal
2019/09/04 - Atual Mesenchymal Stromal Cells (MSC)-derived extracellular vesicles (EVs) for the delivery of RNAi to modulate angiogenesis in malignancy
Orientador de Cristiana da Silva Ulpiano
 Biotecnologia e Biociências (Doutoramento)
Instituto Superior Técnico, Universidade de Lisboa, Portugal
2018/09/01 - Atual Deciphering the cellular crosstalk in the bone marrow microenvironment of acquired aplastic anemia towards the expansion of transplantable hematopoietic stem/progenitor cells
Orientador
 Biotecnologia e Biociências (Doutoramento)
Instituto Superior Técnico, Universidade de Lisboa, Portugal
2017/02/01 - 2024/01 From Umbilical Cord Blood Stem/Progenitor Cells to T Cells: a Scalable and Bioengineering Approach of the Thymic Microenvironment
Orientador
 Bioengenharia (Doutoramento)
Instituto Superior Técnico, Universidade de Lisboa, Portugal
2017/12/06 - 2023/11 Design and Operation of a Prototype Bioreactor for the Expansion and In Situ Selection of Human Hematopoietic Stem/Progenitor Cells
Coorientador
 Bioengenharia (Doutoramento)
Instituto Superior Técnico, Universidade de Lisboa, Portugal
2022/01 - 2022/12 Expansion of urothelial cells and smooth muscle cells under xenogeneic-free conditions for bladder tissue engineering
Orientador
 Post-doctoral research in Stem Cell Engineering (Outra)
Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
2020/11 - 2022/10 Development of a robust process for GMP manufacture of a cell-microcarrier combination for muscle repair
Orientador
 Post-doctoral Research in Stem Cell Engineering (Outra)
Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
2020/09/30 - 2021/12/02 Breaking Down Mesenchymal Stem/Stromal Cells: Uncovering the Potential of Decellularized Extracellular Matrix
Orientador
 Biotecnologia (Mestrado)
Instituto Superior Técnico, Universidade de Lisboa, Portugal
2018/02/07 - 2021/10 Extracellular Vesicles (EVs) from Human Mesenchymal Stem/Stromal Cells (MSC) for the Delivery of Anticancer Peptides
Orientador de Miguel de Almeida Fuzeta
 Bioengenharia (Doutoramento)
Instituto Superior Técnico, Universidade de Lisboa, Portugal
2017/02/01 - 2021/10 Development of a cell-based therapy with genetically-modified mesenchymal stem/stromal cells for aggressive triple-negative breast cancers
Orientador
 Bioengenharia (Doutoramento)
Instituto Superior Técnico, Universidade de Lisboa, Portugal
2015/10/28 - 2021/01/27 Extracellular vesicles: agents of gut communication in prediabetes scenario
Coorientador
 Bioengenharia (Doutoramento)
Instituto Superior Técnico, Universidade de Lisboa, Portugal

Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Fundação Champalimaud, Portugal
2020/02/17 - 2021/01/21 Evaluation and establishment of isolation and culture methodologies for mesenchymal stromal cells from umbilical cord matrix and adipose tissue towards the development of a cell therapy for autoimmune diseases
Orientador
 Engenharia Biomédica (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2015/10/28 - 2020/09/23 RETINAL NEOVASCULARIZATION: TOWARDS THE DEVELOPMENT OF A DUAL-ACTING ANTI-ANGIOGENIC GENE THERAPY
Coorientador
 Bioengenharia (Doutoramento)
Instituto Superior Técnico, Universidade de Lisboa, Portugal

Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2014/10/02 - 2020/07/17 On the Role of Senescent Cells in Spinal Cord Injury
Coorientador
 Bioengenharia (Doutoramento)
Instituto Superior Técnico, Universidade de Lisboa, Portugal

Universidade de Lisboa Faculdade de Medicina, Portugal
2014/10/02 - 2020/07/14 Dissecting the Mechanisms of Notch Signalling in Human HSCs: Implications in Stem Cell Expansion
Coorientador
 Bioengenharia (Doutoramento)
Instituto Superior Técnico, Universidade de Lisboa, Portugal

European Cancer Stem Cell Research Institute, Reino Unido
2014/10/02 - 2020/04/28 Nano structured materials to influence cells
Orientador
 Bioengenharia (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal

Imperial College London, Reino Unido
2015/09 - 2020/04 Tuning extracellular cues to regulate epithelial cell phenotype
Orientador
 Bioengenharia (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2018/09/17 - 2019/11/22 Ribonucleoprotein (RNP) transfection efficiency of Cas9 endonuclease from Streptococcus pyogenes in human mesenchymal stem/stromal cells: impact of donor-to-donor variability and different tissue sources
Coorientador
 Biotecnologia (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2019/03 - 2019/11 Engineering of smart exosomes for clearance of Abeta amyloid protein in Alzheimer’s disease
Coorientador
 Engenharia Biomédica (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2015/02/18 - 2019/09/09 Development of an integrated platform for the downstream processing of monoclonal antibodies combining aqueous two-phase extraction and convective flow devices
Coorientador de Sara Alexandra da Silva Lourenço Rosa
 Biotecnologia e Biociências (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2015/09 - 2019/09 A phenylboronate chromatography based approach as an effective alternative for the downstream processing of biomolecules
Coorientador
 Biotecnologia e Biociências (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2015/01/22 - 2019/07/09 Characterization of the gamma-delta1+ T Cell Receptor repertoire during early and adult human life: implication of clonal diversity for cancer immunotherapy
Coorientador
 Bioengenharia (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2014/10/02 - 2019/07/01 Expansion and in-depth characterization of antigen-specific regulatory T cells in vitro for subsequent clinical translation
Coorientador
 Bioengenharia (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2015/07 - 2019/07 Characterization of the Vdelta1+ T Cell Receptor repertoire during early and adult human life: implication of clonal diversity for cancer immunotherapy
Coorientador
 Bioengenharia (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2014/06/07 - 2019 Ex-vivo gene therapy to improve the regenerative features of human mesenchymal stem/stromal cells (MSC) in a model of limb ischemia
Coorientador
 Bioengenharia (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2012/09/17 - 2018/12/11 Scalable Platform for the Expansion of Human Mesenchymal Stem/Stromal Cells Under Dynamic Conditions
Coorientador
 Bioengenharia (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2014/02/03 - 2018/12/04 Stem cell-mediated bone formation on biomimetic 3-D matrices
Coorientador
 Bioengenharia (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2014/01/23 - 2018/11/20 Towards the development of potency assays and 3D inflammation models to evaluate the regenerative potential of Mesenchymal Stem/Stromal Cell (MSC) and MSC-derived products
Orientador
 Bioengenharia (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2014/01/23 - 2018/11/15 Towards the Development of a Mesenchymal Stem/Stromal Cell Product with Enhanced Therapeutic Features for Myocardial Infarction
Orientador
 Bioengenharia (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2017/09 - 2018/11 Modulating the Regenerative Features of Human Mesenchymal Stem/Stromal Cells with SDF-1a: A Gene Therapy Approach Using Minicircles
Coorientador
 Biotecnologia (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2017/09 - 2018/11 RNAi as a tool to inhibit the angiogenic potential of human Mesenchymal Stem/Stromal Cells in malignancy
Coorientador
 Biotecnologia (Mestrado)
Instituto Superior Técnico, Universidade de Lisboa, Portugal
2014/02/03 - 2018/10/18 Exploring the immunomodulatory role of sialic acids to improve dendritic cell-based vaccines
Coorientador
 Bioengenharia (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2013/01/03 - 2018/05/09 Stem cell engineering approaches towards angiogenic cell therapy for ischemic diseases
Orientador
 Biotecnologia e Biociências (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2012/09/17 - 2017/05/24 Engineering the microenvironment of Mesenchymal Stem/ Stromal Cells (MSC) to tune their trophic activity
Coorientador
 Bioengenharia (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2012/09/17 - 2017/03/17 Scalable manufacturing of mesenchymal stem/stromal cells for cell therapies and the role of the Notch signaling pathway in the human hematopoietic system
Coorientador
 Bioengenharia (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2015/09 - 2016/11 Ex-vivo Expansion of Umbilical Cord Blood Hematopoietic Stem Cells
Coorientador
 Biotecnologia (Mestrado)
Instituto Superior Técnico, Universidade de Lisboa, Portugal
2011/09/09 - 2016/02/25 Analysis of the Gene Regulatory Network underlying pluripotenciality in mouse Embryonic Stem cells
Coorientador
 Bioengenharia (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2014/09/20 - 2015/12/22 Differentiation of Human Mesenchymal Stem/Stromal Cells into Myogenic Cells for Urethral Sphincter Muscle Engineering
Orientador
 Biotecnologia (Mestrado)
Instituto Superior Técnico, Universidade de Lisboa, Portugal
2011/09/09 - 2015/11/27 Tissue Engineering Approaches to Stress Urinary Incontinence using Acellular Urethra Bioscaffolds
Orientador
 Bioengenharia (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2015/03 - 2015/11 Evaluation of the cardiac regenerative potential of mesenchymal stem/stromal cells from different human sources
Orientador
 Engenharia Biomédica (Mestrado)
Instituto Superior Técnico, Universidade de Lisboa, Portugal
2010/10/12 - 2015/06/18 Novel Immunotherapy Strategies with Genetically-Engineered Human Mesenchymal Stem/Stromal Cells using Non-Viral Vectors
Orientador
 Biotecnologia e Biociências (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2009/10/15 - 2015/04/27 Engineering The Microenvironment Of Human Umbilical Cord Blood Hematopoietic Stem/Progenitor Cells Towards Efficient Megakaryocytic Lineage Differentiation And Platelet Production Ex-vivo
Coorientador
 Bioengenharia (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2014/02/16 - 2014/12/12 Comprehensive characterization of human mesenchymal stem/stromal cells from healthy donors and acute myocardial infarction patients
Orientador
 Ciências de Engenharia - Engenharia Biomédica (Mestrado)
Instituto Superior Técnico, Universidade de Lisboa, Portugal
2008/09/01 - 2013/12/16 Platforms to modulate the activity of hematopoietic stem cells and their progenies
Coorientador
 Bioengenharia (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2013/03 - 2013/11 Optimizing the production of human mesenchymal stem/stromal cells in xeno-free microcarrier-based reactor systems
Orientador
 Engenharia Biológica (Mestrado)
Instituto Superior Técnico, Universidade de Lisboa, Portugal
2013/02 - 2013/11 Strategies for optimization of ex-vivo expansion of human hematopoietic stem/progenitor cells from the umbilical cord blood
Orientador
 Engenharia Biomédica (Mestrado)
Instituto Superior Técnico, Universidade de Lisboa, Portugal
2012/09 - 2013/11 Maximizing human mesenchymal stem/stromal cells therapeutic potential through 3-D cell cultivation
Orientador
 Biotecnologia (Mestrado)
Instituto Superior Técnico, Universidade de Lisboa, Portugal
2012/03 - 2012/12 Proliferative Potential and Immunomodulatory Secretory Profile of Human Mesenchymal Stem Cells from Healthy Donors and Acute Myocardial Infarction Patients: A Comparative Study
Orientador
 Engenharia Biomédica (Mestrado)
Instituto Superior Técnico, Universidade de Lisboa, Portugal
2011/09 - 2012/12 Cultivation of Human Mesenchymal Stem Cells as 3-D Aggregates To Enhance Their Therapeutic Potential
Orientador
 Biotecnologia (Mestrado)
Instituto Superior Técnico, Universidade de Lisboa, Portugal
2012/03 - 2012/11 Isolation and Ex-vivo Expansion of Endothelial Progenitor Cells From The Umbilical Cord Blood
Orientador
 Engenharia Biomédica (Mestrado)
Instituto Superior Técnico, Universidade de Lisboa, Portugal
2011/09 - 2012/10 A Novel Process For Human Hematopoietic Stem Cell Selection
Orientador
 Biotecnologia (Mestrado)
Instituto Superior Técnico, Universidade de Lisboa, Portugal
2011/09 - 2012/10 Effect Of Electrospun Nanofibrous Matrices On Co-Culture Of Hematopoietic Stem Cells And Mesenchymal Stem Cells
Coorientador
 Bioengenharia e Nanossistemas (Mestrado)
Instituto Superior Técnico, Universidade de Lisboa, Portugal
2007/08/06 - 2012/07/12 Acoustic Biosensors for Biomedical and Biotechnology Applications
Coorientador
 Bioengenharia (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2011/09 - 2012/07 Ex -Vivo Expansion Of Human Hematopoietic Stem/Progenitor Cells From The Umbilical Cord Blood For Cellular Therapy
Orientador
 Biotecnologia (Mestrado)
Instituto Superior Técnico, Universidade de Lisboa, Portugal
2007/08/06 - 2012/04/23 Ex Vivo Engineered Combinatorial Micro-Environments for Stem Cell Fate Studies - The Balance Between Stem Cell Self-Renewal and Differentiation
Orientador
 Bioengenharia (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2007/08/06 - 2011/12/15 Bioreactor Culture Systems for the Expansion of Mouse Embryonic Stem Cells
Coorientador
 Bioengenharia (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2007/09/20 - 2011/09/21 Design and operation of bioreactor systems for the expansion and controlled neural differentiation of stem cells
Coorientador
 Bioengenharia (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2007/10/25 - 2011/07/27 Isolation and Ex-vivo Expansion of Mesenchymal Stem Cells for Supplementation During Hematopoietic Stem Cell Transplantation
Coorientador
 Biotecnologia e Biociências (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2007/08/06 - 2011/07/26 Novel Approaches for the Isolation and Ex-vivo Expansion of Hematopoietic Stem Cells from Human Umbilical Cord Blood for Cell Therapy
Coorientador
 Bioengenharia (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2007/08/06 - 2011/01/21 Strategies for Myogenic Differentiation of Adult Stem Cells Towards Therapeutic Applications
Orientador
 Bioengenharia (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2009/09/15 - 2010/12/02 Valorization of blood sub-products for Regenerative Medicine and Stem Cell Research
Orientador
 Biotecnologia (Mestrado)
Instituto Superior Técnico, Universidade de Lisboa, Portugal
2007 - 2007 Expansion of Hematopoietic Stem Cells: Optimization of Co-Culture with Human Stroma
Coorientador
 Engenharia Biológica (Mestrado)
Instituto Superior Técnico, Universidade de Lisboa, Portugal
2007 - 2007 In Vitro Expansion of Human Mesenchymal Stem Cells in Stirred Culture Systems
Coorientador
 Engenharia Biológica (Mestrado)
Instituto Superior Técnico, Universidade de Lisboa, Portugal
2006 - 2007 Scale-Up of Mouse Embryonic Stem Cell Expansion in a Stirred Culture System
Coorientador
 Biotecnologia (Mestrado)
Instituto Superior Técnico, Universidade de Lisboa, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2018 - 2018 Annual Meeting of Associação Portuguesa de Intervenção Cardiovascular (APIC), Symposium Heart Without Borders with ...Interventional Cardiology Tróia (Co-Chair) (2018)
Oficina (workshop) (Coorganizador)
 Associação Portuguesa de Intervenção Cardiovascular (APIC), Portugal
2009/04/28 - 2009/04/29 4th International Meeting of Sociedade Portuguesa de Células Estaminais e Terapia Celular (SPCE-TC), "Novel Frontiers in Stem Cell Research" Lisboa, 28-29 Abril 2009 (Co-Chair with Joaquim M. S. Cabral) (2009/04/28 - 2009/04/29)
Encontro
 Universidade de Lisboa Instituto Superior Técnico, Portugal

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2021/12 Exploring Mesenchymal Stem/Stromal Cells Immunomodulatory Potential in Intervertebral Disc Degeneration
Arguente principal
 JOANA RITA CARDOSO BRANDÃO E PINTO (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/12/20 METABOLIC MODULATION IN PAUSED-LIKE PLURIPOTENCY
Arguente principal
 Maria Inês Ramalho de Almeida e Sousa (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2020/07 Exploring the interplay between the peripheral nervous system and bone marrow-resident cells: impact on bone regeneration and axonal guidance
Arguente principal
 LUÍS PEDRO DE ARAÚJO LEITÃO (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018 Diogo Gomes da Silva, “Engineering of T Cells With Chimeric Antigen Receptors as a Therapy For Hematologic Cancers”, PhD in Bioengineering: Cell Therapies and Regenerative Medicine, IST-UL (2018)
Vogal
 Diogo Gomes da Silva (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2018 Marta Silva, “Stem cell bioprocessing strategies for cardiac regeneration - Unveiling CCBE1 role as a modulator of cardiomyocyte differentiation”, PhD in Engineering and Technology Sciences, Biomedical Engineering, ITQB, Universidade Nova de Lisboa (2018) (Opponent)
Arguente principal
 Marta Silva (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018 Ana Catarina Silva, “Identification of native cardiogenic niche-feature(s) for improved cardiac cell response: the role of the extracellular matrix”, PhD in Molecular and Cellular Biotechnology applied to Health Sciences, Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto (2018) (Opponent)
Arguente principal
 Ana Catarina Silva (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018 Andreia Gomes, “Elucidating Blood Origin: from reprogramming to ontogeny”, PhD in Experimental Biology and Biomedicine, Universidade de Coimbra (2018) (Opponent)
Arguente principal
 Andreia Gomes (Doutoramento)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2017 Arantxa Blásquez Prunera, “Effect of a good-manufacturing-practice xeno-free medium on mesenchymal stromal cell properties: Multipotentiality, Immunomodulation and Recruitment”, PhD in Biomedical Engineering, Faculty of Engineering, Universidade do Porto (2017) (Opponent)
Arguente principal
 Arantxa Blásquez Prunera (Doutoramento)
Universidade do Porto Faculdade de Engenharia, Portugal
2017 Ewa Bauman, “Integrating xeno-free strategies with spheroid culture for stem cell-based therapies”, PhD in Biomedical Engineering, Faculty of Engineering, Universidade do Porto (2017) (Opponent)
Arguente principal
 Ewa Bauman (Doutoramento)
Universidade do Porto Faculdade de Engenharia, Portugal
2017 Tânia Perestrelo, “Framing Pluripotency: from gene to image”, PhD in Experimental Biology and Biomedicine, Universidade de Coimbra (2017) (Opponent)
Arguente principal
 Tânia Perestrelo (Doutoramento)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2017 Ivana Kostic, “Stem cell and stem cell-free based therapeutics against myocardial infarction”, PhD in Bioengineering MIT-Portugal Program, IST-UL (2017) (Opponent)
Arguente
 Ivana Kostic (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2016 Bárbara Cunha, “Development of integrated strategies for the downstream processing of human stem cells for clinical application”, PhD in Bioengineering MIT-Portugal Program, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa (2016) (Opponent)
Arguente principal
 Bárbara Cunha (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2016 Carla Moura, “Design and fabrication of zonal cartilage constructs”, PhD in Bioengineering MIT-Portugal Program, IST-UL (2016)
Vogal
 Carla Moura (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2015 Ana de Oliveira Marques, "Exploring the secretome of mesenchymal like stem cells for central nervous system regenerative medicine: a focus on Parkinson's disease", PhD in Health Sciences, Escola das Ciências da Saúde, Universidade do Minho (2015) (Opponent)
Arguente principal
 Ana de Oliveira Marques (Doutoramento)
Universidade do Minho, Portugal
2015 Aruna Santhagunam, “Synovial Mesenchymal Stromal Cells For Cartilage Repair”, PhD in Biotechnology, IST-UL (2015)
Vogal
 Aruna Santhagunam (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2015 Marcelo Correia, “Mechanisms underlying metabolic shift in pluripotent stem cells: The potential role of sirtuins”, PhD in Experimental Biology and Biomedicine, Universidade de Coimbra (2015) (Opponent)
Arguente principal
 Marcelo Correia (Doutoramento)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2015 Mónica Coelho, “Immunomodulatory activity of mesenchymal stromal cells”, PhD in Bioengineering MIT-Portugal Program, IST-UL (2015)
Vogal
 Mónica Coelho (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2015 Sofia Rebelo, "Development of 3D in vitro models for prediction of hepatic metabolism and toxicity", PhD in Bioengineering MIT-Portugal Program, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa (2015) (Opponent)
Arguente principal
 Sofia Rebelo (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2013 Sandro Pereira, “A metabolic switch for cell differentiation”, PhD in Biology - Cellular Biology, Faculdade de Ciências e Tecnologia, Universidade de Coimbra (2013) (Opponent)
Arguente principal
 Sandro Pereira (Doutoramento)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2013 Diogo da Fonseca Pereira, “Role of the neurotrophic factor receptor ret in haematopoiesis”, PhD in Biomedical Sciences -Immunology, Faculdade de Medicina, Universidade de Lisboa (2013) (Opponent)
Arguente
 Diogo da Fonseca Pereira (Doutoramento)
Universidade de Lisboa Faculdade de Medicina, Portugal
2013 Marta Dias, “Scaffold Design for Bone Tissue Engineering”, PhD in Biomedical Engineering, IST-UL (2013)
Vogal
 Marta Dias (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2012 Andreia Madeira, “Genome-Wide Expression Approaches Applied To Biomedical Research: Long-term adaptation of Burkholderia cenocepacia to cystic fibrosis patient's airways and extended ex-vivo cultivation of human mesenchymal stem cells”, PhD in Biotechnology, IST-UTL (2012)
Vogal
 Andreia Madeira (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2009 Ana Isabel Silva, “Study of a membrane bioreactor as a model of bioartificial pancreas”, PhD in Chemical Engineering, IST-UTL (2009)
Vogal
 Ana Isabel Silva (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2009 Tiago Fernandes, “Cell-based microarray systems for stem cell expansion and differentiation”, PhD in Biotechnology, IST-UTL (2009)
Vogal
 Tiago Fernandes (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2009 Márcio Temtem, “Development of biocompatible and "smart" porous structures using CO2-assisted processes”, PhD in Chemical Engineering, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa (2009) (Opponent)
Arguente
 Márcio Temtem (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Arbitragem científica em conferência

Nome da conferência Local da conferência
2010 - 2020 International Meeting of Sociedade Portuguesa de Células Estaminais e Terapia Celular (SPCE-TC)

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2012 - Atual BMC Biotechnology (1472-6750) Springer (Biomed Central Ltd.)

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2018 - 2018 Research Grant Peer Reviewer, Regenerative Medicine Research, Medical Research Council (MRC), UK, 2018
Avaliador
 Medical Research Council, Reino Unido Medical Research Council
2015 - 2015 Evaluation Panel of the National FCT Call for individual PhD fellowships (Area: Bioengineering and Biotechnology), 2015 Fundação para a Ciência e a Tecnologia
2013 - 2013 Research Grant Peer Reviewer, Regenerative Medicine Research, Medical Research Council (MRC), UK, 2013
Avaliador
 Medical Research Council, Reino Unido Medical Research Council

Membro de associação

Nome da associação Tipo de participação
2019/11/09 - Atual EATRIS - EUROPEAN INFRASTRUCTURE FOR TRANSLATIONAL MEDICINE Platform for ATMPs (ADVANCED THERAPY MEDICINAL PRODUCTS) iBB representative
2018 - Atual Regenerative Medicine Manufacturing section, European Society of Biochemical Engineering Sciences (ESBES) Member
2014 - Atual International Society of Cellular Therapy (ISCT)
2005 - Atual Portuguese Society for Stem Cells and Cellular Therapy (Sociedade Portuguesa de Células Estaminais e Terapia Celular (SPCE-TC) Founding Member

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2021/09/01 - Atual Coordinator of the Bachelor in Biomedical Engineering & Vice-Coordinator of the Master in Biomedical Engineering at Instituto Superior Técnico (after re-structuring of the Integrated Master Course - approved by A3ES)
Coordenador
 Instituto Superior Técnico, Universidade de Lisboa, Portugal
2019/01 - Atual Coordination of the Integrated Master in Biomedical Engineering (Vice-Coordinator)
Coordenador
 Instituto Superior Técnico, Universidade de Lisboa, Portugal
2017/02 - Atual Pedagogical Council of Instituto Superior Técnico, Universidade de Lisboa, Commission for the Quality of Curricular Units
Membro
 Instituto Superior Técnico, Universidade de Lisboa, Portugal
2016 - Atual Scientific Committee of the Integrated Master in Biological Engineering
Membro
 Instituto Superior Técnico, Universidade de Lisboa, Portugal
2015 - Atual Scientific Council of iBB-Institute for Bioengineering and Biosciences, Instituto Superior Técnico
Membro
 Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
2013 - Atual Member of the Scientific Committee of the International Doctoral Program in Bioengineering – Cell Therapies and Regenerative Medicine, a FCT funded PhD program, in collaboration with Rensselaer Polytechnic Institute (RPI), USA, and Universidade Nova de Lisboa
Membro
 Instituto Superior Técnico, Universidade Técnica de Lisboa, Portugal
2011/01 - Atual Scientific Council of Department of Bioengineering, Instituto Superior Técnico
Membro
 Instituto Superior Técnico, Universidade de Lisboa, Portugal
2021/05 - 2022/12 Commission for 3rd Cycle - Pedagogical Council and Scientific Council, Instituto Superior Técnico
Membro
 Universidade de Lisboa Instituto Superior Técnico, Portugal
2015/10 - 2019/10 Vice-President of the Portuguese Society for Stem Cells and Cellular Therapy (Sociedade Portuguesa de Células Estaminais e Terapia Celular (SPCE-TC)
Presidente / Vice-presidente
 Sociedade Portuguesa de Células Estaminais e Terapia Celular, Portugal
2008 - 2015 Coordination of the Master Course in Bioengineering and Nanosystems
Membro
 Instituto Superior Técnico, Universidade de Lisboa, Portugal
Distinções

Prémio

2009 Prémio Jovens Investigadores UTL/Deloitte - scientific domains of Biological Engineering, Biochemistry and Biotechnology
2008 First Annual FLAD Educational Innovation Award 2008 - within the frame of the international collaboration program between Massachussets Institute of Technology (MIT) (USA) and the Portuguese Government (the MIT-Portugal Program), Bioengineering Focus Area
Fundação Luso-Americana, Portugal

Outra distinção

2009 Nomination as an Outstanding Young Scientist for the InterAcademy Panel (IAP) / World Economic Forum (WEF) for participation in the 2nd IAP Conference for Young Scientists in conjunction with WEF’s Annual Meeting of the New Champions, “Summer Davos”
InterAcademy Panel (IAP) / World Economic Forum (WEF), China
2008 Honorable Mention “Prémio Jovens Investigadores UTL/Deloitte” (Young Investigator Award UTL/Deloitte) - scientific domains of Biological Engineering, Biochemistry and Biotechnology
UTL/Deloitte, Portugal
2001 Merit Diploma - Chemical Engineering
Instituto Superior Técnico, Universidade Técnica de Lisboa, Portugal