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Emanuel Monteiro Candeias. Completed the Doutoramento in Biologia Experimental e Biomedicina in 2021/11/23 by Universidade de Coimbra Instituto de Investigação Interdisciplinar, Mestrado in Bioquímica in 2011 by Universidade de Coimbra Faculdade de Ciencias e Tecnologia and Licenciatura in Biologia in 2009 by Universidade de Coimbra Faculdade de Ciencias e Tecnologia. Is Postdoctoral Fellow in Universidade de Coimbra. Published 25 articles in journals. Has 8 section(s) of books. Participated in 10 event(s). Supervised 1 work(s) of course completion of LSc/BSc. Has received 8 awards and/or honors. Works in the area(s) of Medical and Health Sciences with emphasis on Health Sciences, Natural sciences with emphasis on Biological Sciences with emphasis on Cell Biology, Natural sciences with emphasis on Biological Sciences with emphasis on Biology and Natural sciences with emphasis on Biological Sciences with emphasis on Molecular Biology. In his curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: Envelhecimento; Hipoxia crónica; Stress oxidativo; Lesão oxidativa; Fígado; Doenças neurodegenerativas; Controlo de qualidade proteica; Exercisio Fisico; Restrição Calórica; Diabetes tipo 2; Exendina-4; Neuroprotecção; Receptor do peptídeo-1 de glucagão; Espécies reactivas de oxigénio da mitocôndria; Pré-condicionamento; Doença de Alzheimer; Mitochondria; innate imune response; microbiome; intestinal barrier; .
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Identificação

Identificação pessoal

Nome completo
Emanuel Monteiro Candeias

Nomes de citação

  • Candeias, Emanuel

Identificadores de autor

Ciência ID
6515-BCC3-762D
ORCID iD
0000-0002-8511-5821

Telefones

Telemóvel
  • (+351) 938717762 (Pessoal)

Domínios de atuação

  • Ciências Médicas e da Saúde - Ciências da Saúde
  • Ciências Naturais - Ciências Biológicas - Biologia Celular
  • Ciências Naturais - Ciências Biológicas - Biologia
  • Ciências Naturais - Ciências Biológicas - Biologia Molecular

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Formação
Grau Classificação
2012/09/01 - 2021/11/23
Concluído
 Biologia Experimental e Biomedicina (Doutoramento)
Especialização em Neurociência e Doença
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
"The amazing anti-type 2 diabetic drugs in neurodegeneration: the impact of exendin-4, liraglutide and linagliptin in type 2 diabetes, Alzheimer disease and Parkinson disease" (TESE/DISSERTAÇÃO)
 Aprovado com Distinção e Louvor
2015/09/12
Concluído
 Curso de Ciências em Animais de Laboratório categoria C (Outros)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2011
Concluído
 Bioquímica (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Effect of age and chronic hypoxia on oxidative status, mitochondria and apoptosis in rat liver" (TESE/DISSERTAÇÃO)
 17
2009
Concluído
 Biologia (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"n/a" (TESE/DISSERTAÇÃO)
 13
Percurso profissional

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2023/06/14 - Atual Postdoctoral Fellow Universidade de Coimbra, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2022/02/15 - 2023/05/31 Junior Researcher, PhD Universidade de Coimbra, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2021/05/24 - 2021/10/09 Master Research Fellow, HealthyAging2020 BIM 2.1.3 Universidade de Coimbra, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2020/03/01 - 2020/08/31 Master Research Fellow, HealthyAging2020, BIM 2.2.2 Universidade de Coimbra, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2017/03/01 - 2020/02/29 Master Research Fellow , "The toxinogenic gut microbiome in sporadic Parkinson’s Disease: a quest for new “antiPDbiotics”, BIM:MB-40-2016, PRÉMIO SANTA CASA NEUROCIÊNCIAS MANTERO BELARD 2016 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2015/08/15 - 2016/03/31 Invited PhD student Cesare Patrone’s research group at Department of Clinical Science and Education, Söderjukhuset, Karolinska Institutet, Suécia
2012/03/01 - 2013/02/28 Master Research Fellow, "Mitochondrial preconditioning: potential neuroprotective effect in Alzheimer’s disease (PTDC/SAUNMC/110990/2009) Fundação para a Ciência e a Tecnologia, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2011/02/01 - 2012/01/31 Research Fellow, "The pathological interaction between diabetes and Alzheimer’s disease: exploring the role of brain endothelial mitochondria and uncoupling proteins (PTDC/SAU–NEU/103325/2008) Fundação para a Ciência e a Tecnologia, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Projetos

Projeto

Designação Financiadores
2021 - 2024 STOPD - The Gut-Immune-Brain Axis in Parkinson disease
PTDC/MED-NEU/3644/2020 (248.992 ¿)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2021 - 2024 The Gut-Immune-Brain Axis in Parkinson disease
PTDC/MED-NEU/3644/2020 (248.992 ¿)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2018/06/15 - 2021/06/14 O papel dos mecanismos de controlo de qualidade da perda da homeostase proteica nas doenças neurodegenerativas associadas à idade
PTDC/MED-NEU/30712/2017
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2012/05/01 - 2014/10/31 Impacto da terapia com exendina-4 nos mecanismos moleculares subjacentes à disfunção cerebral associada à diabetes tipo 2 a longo prazo
PTDC/SAU-TOX/117481/2010
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade da Beira Interior, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2011/03/01 - 2013/08/31 Pré-condicionamento via mitocôndria: potencial efeito neuroprotector na doença de Alzheimer
PTDC/SAU-NMC/110990/2009
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em revista
  1. Magalhães, João Duarte; Candeias, Emanuel; Melo-Marques, Inês; Abreu, António E.; Pereira-Santos, Ana Raquel; Esteves, Ana Raquel; Cardoso, Sandra Morais; Empadinhas, Nuno. "Nocardia cyriacigeorgica Elicits Gut Disturbances in a Leaky Gut Model of Colitis, but Not the Harmful Cascade Leading to Gut-First Parkinson’s Disease". International Journal of Molecular Sciences 25 6 (2024): 3423. http://dx.doi.org/10.3390/ijms25063423.
    10.3390/ijms25063423
  2. Munoz Pinto, Mario; Candeias, Emanuel; Esteves, Ana Raquel; Ana Branco Maranha Tiago 301C-9125-034E; Melo-Marques I; João Duarte Magalhães; Reis Carneiro, Diogo; et al. "Gut-first Parkinson’s disease is encoded by a transmissible gut dysbiome.". (2024):
    Submetido
  3. Esteves, A. Raquel; Silva, Diana F.; Banha, Diogo; Candeias, Emanuel; Guedes, Beatriz; Cardoso, Sandra M.. "LPS-induced mitochondrial dysfunction regulates innate immunity activation and a-synuclein oligomerization in Parkinson's disease". Redox Biology 63 (2023): 102714. http://dx.doi.org/10.1016/j.redox.2023.102714.
    10.1016/j.redox.2023.102714
  4. D. Magalhães, João; Candeias, Emanuel; Melo-Marques, Inês; Silva, Diana F.; Esteves, A. Raquel; Empadinhas, Nuno; Cardoso, Sandra Morais. "Intestinal infection triggers mitochondria-mediated a-synuclein pathology: relevance to Parkinson¿s disease". Cellular and Molecular Life Sciences 80 6 (2023): http://dx.doi.org/10.1007/s00018-023-04819-3.
    10.1007/s00018-023-04819-3
  5. Magalhães, João D.; Esteves, Ana Raquel; Candeias, Emanuel; Silva, Diana F.; Empadinhas, Nuno; Cardoso, Sandra Morais. "The Role of Bacteria–Mitochondria Communication in the Activation of Neuronal Innate Immunity: Implications to Parkinson’s Disease". International Journal of Molecular Sciences 24 5 (2023): 4339. http://dx.doi.org/10.3390/ijms24054339.
    10.3390/ijms24054339
  6. Diniz, Antónia; Alves, Marco G.; Candeias, Emanuel; Duarte, Ana I.; Moreira, Paula I.; Silva, Branca M.; Oliveira, Pedro F.; Rato, Luís. "Type 2 Diabetes Induces a Pro-Oxidative Environment in Rat Epididymis by Disrupting SIRT1/PGC-1a/SIRT3 Pathway". International Journal of Molecular Sciences 23 16 (2022): 8912. http://dx.doi.org/10.3390/ijms23168912.
    10.3390/ijms23168912
  7. Esteves, A Raquel; Munoz-Pinto, Mário F; Nunes-Costa, Daniela; Candeias, Emanuel; Silva, Diana F; Magalhães, João D; Pereira-Santos, A Raquel; et al. "Footprints of a microbial toxin from the gut microbiome to mesencephalic mitochondria". Gut (2021): gutjnl-2021. http://dx.doi.org/10.1136/gutjnl-2021-326023.
    10.1136/gutjnl-2021-326023
  8. Silva, Diana F.; Candeias, Emanuel; Esteves, A. Raquel; Magalhães, João D.; Ferreira, I. Luísa; Nunes-Costa, Daniela; Rego, A. Cristina; Empadinhas, Nuno; Cardoso, Sandra M.. "Microbial BMAA elicits mitochondrial dysfunction, innate immunity activation, and Alzheimer’s disease features in cortical neurons". Journal of Neuroinflammation 17 1 (2020): http://dx.doi.org/10.1186/s12974-020-02004-y.
    10.1186/s12974-020-02004-y
  9. Candeias, Emanuel. "Dipeptidyl peptidase-4 inhibitors and sulfonylureas prevent the progressive impairment of the nigrostriatal dopaminergic system induced by diabetes during aging". Neurobiology of Aging (2020): http://dx.doi.org/10.1016/j.neurobiolaging.2020.01.004.
    10.1016/j.neurobiolaging.2020.01.004
  10. Candeias, Emanuel. "Liraglutide Protects Against Brain Amyloid-ß1–42 Accumulation in Female Mice with Early Alzheimer’s Disease-Like Pathology by Partially Rescuing Oxidative/Nitrosative Stress and Inflammation". International Journal of Molecular Sciences (2020): http://dx.doi.org/10.3390/ijms21051746.
    10.3390/ijms21051746
  11. Candeias, Emanuel. "New Multitarget Hybrids Bearing Tacrine and Phenylbenzothiazole Motifs as Potential Drug Candidates for Alzheimer’s Disease". Molecules (2019): http://dx.doi.org/10.3390/molecules24030587.
    10.3390/molecules24030587
  12. Luca Piemontese; Daniel Tomás; Asha Hiremathad; Vito Capriati; Emanuel Candeias; Sandra M. Cardoso; Sílvia Chaves; M. Amélia Santos. "Donepezil structure-based hybrids as potential multifunctional anti-Alzheimer’s drug candidates". Journal of Enzyme Inhibition and Medicinal Chemistry 33 1 (2018): 1212-1224. https://doi.org/10.1080/14756366.2018.1491564.
    10.1080/14756366.2018.1491564
  13. Karam Chand; Rajeshwari Rajeshwari; Emanuel Candeias; Sandra M. Cardoso; Sílvia Chaves; M. Amélia Santos. "Tacrine–deferiprone hybrids as multi-target-directed metal chelators against Alzheimer's disease: a two-in-one drug". Metallomics 10 10 (2018): 1460-1475. https://doi.org/10.1039/C8MT00143J.
    10.1039/C8MT00143J
  14. Candeias, Emanuel. "Middle-Aged Diabetic Females and Males Present Distinct Susceptibility to Alzheimer Disease-like Pathology". Molecular Neurobiology (2017): http://dx.doi.org/10.1007/s12035-016-0155-1.
    10.1007/s12035-016-0155-1
  15. Candeias, Emanuel. "Brain GLP-1/IGF-1 Signaling and Autophagy Mediate Exendin-4 Protection Against Apoptosis in Type 2 Diabetic Rats". Molecular Neurobiology (2017): http://dx.doi.org/10.1007/s12035-017-0622-3.
    10.1007/s12035-017-0622-3
  16. Candeias, Emanuel. "The role of mitochondrial disturbances in Alzheimer, Parkinson and Huntington diseases". Expert Review of Neurotherapeutics (2015): http://dx.doi.org/10.1586/14737175.2015.1058160.
    10.1586/14737175.2015.1058160
  17. Candeias, Emanuel. "Modulation of Endoplasmic Reticulum Stress: An Opportunity to Prevent Neurodegeneration?". CNS & Neurological Disorders - Drug Targets (2015): http://dx.doi.org/10.2174/1871527314666150429112353.
    10.2174/1871527314666150429112353
  18. Candeias, Emanuel. "Perspectives on mitochondrial uncoupling proteins-mediated neuroprotection". Journal of Bioenergetics and Biomembranes (2015): http://dx.doi.org/10.1007/s10863-014-9580-x.
    10.1007/s10863-014-9580-x
  19. Candeias, Emanuel. "Gut-brain connection: The neuroprotective effects of the anti-diabetic drug liraglutide". World Journal of Diabetes (2015): http://dx.doi.org/10.4239/wjd.v6.i6.807.
    10.4239/wjd.v6.i6.807
  20. Candeias, Emanuel. "The role of endoplasmic reticulum in amyloid precursor protein processing and trafficking: Implications for Alzheimer's disease". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (2014): http://dx.doi.org/10.1016/j.bbadis.2014.05.003.
    10.1016/j.bbadis.2014.05.003
  21. Candeias, Emanuel. "Insulin as a Bridge between Type 2 Diabetes and Alzheimer Disease – How Anti-Diabetics Could be a Solution for Dementia". Frontiers in Endocrinology (2014): http://dx.doi.org/10.3389/fendo.2014.00110.
    10.3389/fendo.2014.00110
  22. Candeias, Emanuel. "Defective HIF Signaling Pathway and Brain Response to Hypoxia in Neurodegenerative Diseases: Not an “Iffy” Question!". Current Pharmaceutical Design (2013): http://dx.doi.org/10.2174/1381612811319380013.
    10.2174/1381612811319380013
  23. Candeias, Emanuel. "Hyperglycemia, Hypoglycemia and Dementia: Role of Mitochondria and Uncoupling Proteins". Current Molecular Medicine (2013): http://dx.doi.org/10.2174/1566524011313040010.
    10.2174/1566524011313040010
  24. Candeias, Emanuel. "Crosstalk between diabetes and brain: Glucagon-like peptide-1 mimetics as a promising therapy against neurodegeneration". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (2013): http://dx.doi.org/10.1016/j.bbadis.2013.01.008.
    10.1016/j.bbadis.2013.01.008
  25. Candeias, Emanuel. "The impairment of insulin signaling in Alzheimer's disease". IUBMB Life (2012): http://dx.doi.org/10.1002/iub.1098.
    10.1002/iub.1098
  26. Candeias, Emanuel. "Alzheimer disease as a vascular disorder: Where do mitochondria fit?". Experimental Gerontology (2012): http://dx.doi.org/10.1016/j.exger.2012.07.006.
    10.1016/j.exger.2012.07.006
  27. Candeias, Emanuel. "Insulin signaling, glucose metabolism and mitochondria: Major players in Alzheimer's disease and diabetes interrelation". Brain Research (2012): http://dx.doi.org/10.1016/j.brainres.2011.12.063.
    10.1016/j.brainres.2011.12.063
Capítulo de livro
  1. Candeias, Emanuel; Nunes-Costa, Daniela; Pereira-Santos, A. Raquel; Magalhães, João Duarte; Melo-Marques, Inês; Guedes, Beatriz; Esteves, A. Raquel; Empadinhas, Nuno; Cardoso, Sandra Morais. "Neurotoxicity induced by the microbial metabolite ß-methylamino-L-alanine: pathways and mechanisms". In Natural Molecules in Neuroprotection and Neurotoxicity, editado por Marcus de Oliveira, 747-778. Elsevier, 2024.
    Publicado • 10.1016/b978-0-443-23763-8.00068-3
  2. Candeias, Emanuel; Nunes-Costa, Daniela; Magalhães, João Duarte; Esteves, Ana Raquel; Ana Raquel Pereira-Santos; Inês Melo Marques; Beatriz Guedes; Empadinhas, Nuno; Cardoso, Sandra Morais. "Neurotoxicity induced by ß-N-methylamino-L-alanine". In In Natural Molecules in Neuroprotection and Neurotoxicity. Elsevier Inc. Publisher, 2022.
    Publicado
  3. Candeias, Emanuel; Nunes-Costa, Daniela; João Duarte Magalhães; Esteves, Ana Raquel; Ana Raquel Pereira-Santos; Inês Melo Marques; Beatriz Guedes; Empadinhas, Nuno; Sandra Morais Cardoso. "Candeias, E, Nunes-Costa D, Magalhães JD, Esteves AR, Pereira-Santos AR, Marques I, Guedes B, Empadinhas N, Cardoso SM. (2022) Neurotoxicity induced by ß-N-methylamino-L-alanine.". In Natural Molecules in Neuroprotection and Neurotoxicity. Elsevier Inc. Publisher., 2022.
    Publicado
  4. Candeias, Emanuel; Magalhães, João Duarte; Santos, Daniel; Costa, Helena; Silva, Diana F.; Esteves, Ana Raquel; Cardoso, Sandra Morais. "The role of autophagy in Parkinson's disease etiopathogenesis". In Genetics, Neurology, Behavior, and Diet in Parkinson's Disease, 101-121. Elsevier, 2020.
    10.1016/b978-0-12-815950-7.00007-2
  5. Candeias, Emanuel. "Mitochondria at the Base of Neuronal Innate Immunity in Alzheimer’s and Parkinson’s Diseases". 2018.
    10.5772/intechopen.72612
  6. Candeias, Emanuel. "Unpuzzling the Comorbid Type 2 Diabetes and Hypertension-Related Cognitive Dysfunction and Stroke". 2017.
    10.1007/978-3-319-45345-3_31
  7. Candeias, Emanuel. "Role of Mitochondria and Oxidative Stress in Parkinson's Disease". 2014.
    10.13140/2.1.1214.8803
  8. Candeias, Emanuel. "The Janus Face of Insulin in Brain". 2013.
    10.1002/9781118395318.ch5
Poster em conferência
  1. Pereira-Santos, Ana Raquel; Candeias, Emanuel; Nunes-Costa, Daniela; Alarico, Susana; Tiago, Igor; Madeira, Nuno; Empadinhas, Nuno; Sandra Morais Cardoso. "2-HIT-SCZ: Unveiling the Gut-Immune-Brain axis in Schizophrenia". Trabalho apresentado em BEBDAY 2024: Not) Knowing What Comes Next: Tools for the research of Tomorrow, 2024.
  2. Pereira-Santos, AR.; Candeias, Emanuel; Esteves, Ana Raquel; João Duarte Magalhães; Nunes-Costa, Daniela; Tiago, Igor; Madeira, Nuno; Empadinhas, Nuno; Sandra Morais Cardoso. "THE PSYCHOBIOME: Unveiling the role of Gut-Immune-Brain axis in Schizophrenia". Trabalho apresentado em ESN-ISN Neurochemistry School 2023, 2023.
  3. Pereira-Santos, AR.; Candeias, Emanuel; Esteves, Ana Raquel; Magalhães, João Duarte; Nunes-Costa, Daniela; Tiago, Igor; Madeira, Nuno; Empadinhas, Nuno; Cardoso, Sandra Morais. "Unveiling the role of Gut-Immune-Brain axis in Schizophrenia". 2023.
  4. Santos, Bárbara; Afonso, Mariana; Alves, André; Amaral, Sandra; Candeias, Emanuel; Cardoso, Maria; Cortes, Luisa; et al. "GreenLabsCIBB - One path for sustainable research". Trabalho apresentado em GreenLabs Portugal Symposium: Promoting sustainability in Research, 2023.
  5. Mendes, Candida; Marques, Carla; Mota, Sandra; Afonso, Mariana; Alves, André; Amaral, Sandra; Candeias, Emanuel; et al. "GreenLabs @CIBB - "Collection Points" - Reuse and Recycling". Trabalho apresentado em GreenLabs Portugal Symposium: Promoting sustainability in Research, 2023.
  6. Ana Raquel Pereira-Santos; Candeias, Emanuel; João Duarte Magalhães; Esteves, Ana Raquel; Empadinhas, Nuno; Sandra Morais Cardoso. "Neuronal control of microglia through the mitochondria". Trabalho apresentado em 17th International Conference on AD/PD, 2023.
  7. Candeias, Emanuel; Inês Melo Marques; Mario Munoz-Pinto; Esteves, Ana Raquel; João Duarte Magalhães; Reis Carneiro, Diogo; Empadinhas, Nuno; Sandra Morais Cardoso. "The gut-immune-brain axis in Parkinson disease". Trabalho apresentado em 17th International Conference on AD/PD, 2023.
  8. Ana Raquel Pereira-Santos; Candeias, Emanuel; Esteves, Ana Raquel; João Duarte Magalhães; Nunes-Costa, Daniela; Igor Tiago; Madeira, Nuno; Empadinhas, Nuno; Sandra Morais Cardoso. "Unveiling the role of gut dysbiosis in Schizophrenia pathology". Trabalho apresentado em FENS-Hertie Winter School: “Neuro-immune interactions in health and disease, 2023.
  9. Magalhães, João; Candeias, Emanuel; Melo-Marques, Inês; Diana F. Silva; Esteves, Ana Raquel; Empadinhas, Nuno; Sandra Morais Cardoso. Autor correspondente: Sandra Morais Cardoso. "Evidence for a-synuclein involvement in innate immune response after bacterial infection: implications to PD". 2023.
  10. Melo-Marques I; Munoz Pinto, Mario; Candeias, Emanuel; Esteves, Ana Raquel; Sandra Morais Cardoso. "Mitochondrial dysfunction triggers ileum innate immunity in a PD mouse model". Trabalho apresentado em VI MeetLab Coimbra (University of Coimbra), 2022.
  11. João Duarte Magalhães; Silva DF; Melo-Marques I; Candeias, Emanuel; Empadinhas, Nuno; Sandra Morais Cardoso. "Listeria monocytogenes infection paradigm to “gut-first PD”". Trabalho apresentado em BEB Day 2022 – The Overview Effect (Coimbra, Portugal), 2022.
  12. Inês Melo Marques; Mario Munoz-Pinto; Candeias, Emanuel; Esteves, Ana Raquel; Sandra Morais Cardoso. "Mitochondria dysfunction triggers ileum innate immunity in a PD mouse model". Trabalho apresentado em VI meet.Lab, 2022.
  13. Esteves, Ana Raquel; Mario Munoz-Pinto; Candeias, Emanuel; Diana F Silva; João Duarte Magalhães; Ildete Luísa Ferreira; Ana Raquel Pereira-Santos; et al. "The Parkinson Pandemic: a microbial toxin elicits Parkinson’s disease-like neurodegeneration". Trabalho apresentado em 55th Annual Scientific Meeting of the European Society for Clinical Investigation, 2021.
  14. Mena, Débora; Alves IN; Silva, D.F; Daniela Silva; Daniela F. Silva; Vaz DE; Candeias, Emanuel; Oliveira CR; Monteiro PF; Moreira PI; Duarte AI. "Diet-induced high cardiovascular risk compromises brain hippocampal metabolism and long-term spatial memory in middle-aged male rats. (Presented as a poster plus a short talk)". Trabalho apresentado em Virtual Meeting of the European Society for Clinical Investigation 2020-COVID19 Edition, 2020.
  15. Candeias, Emanuel; Esteves, A. Raquel; Magalhães, João D.; Silva, Diana F.; Ferreira, I. Luísa; Rego, A. Cristina; Empadinhas, Nuno; Cardoso, Sandra M.. "Pathogen-associated molecular patterns as culprits for mitochondria-driven Parkinson disease neurodegeneration". Trabalho apresentado em 53rd Annual Scientific Meeting of ESCI, 2019.
  16. Magalhães, João D.; Candeias, Emanuel; Esteves, A. Raquel; Alarico, Susana; Tiago, Igor; Ferreira, I. Luísa; Rego, A. Cristina; Empadinhas, Nuno; Cardoso, Sandra M.. "Intensive antibiotic administration generates motor deficits and neuronal mitochondria impairment". Trabalho apresentado em 53rd Annual Scientific Meeting of ESCI, 2019.
  17. Candeias, Emanuel. "Diet-induced high cardiovascular risk impairs brain hippocampal metabolism and long-term spatial memory in middle-aged male rats". Trabalho apresentado em 53rd Annual Scientific Meeting of ESCI, 2019.
  18. Candeias, Emanuel. "The Microbiome-Mitochondria Dance in Prodromal Parkinson's Disease". Trabalho apresentado em 1st CIBB Neuroscience and Disease – Retreat, 2019.
  19. Magalhães, João D.; Candeias, Emanuel; Esteves, Raquel; Alarico, Susana; Tiago, Igor; Empadinhas, Nuno; Cardoso, Sandra Morais. "Intensive antibiotic administration generates motor deficits and neuronal mitochondrial impairment". Trabalho apresentado em 53rd Annual Scientific Meeting of the European Society for Clinical Investigation, Coimbra, Portugal, 2019.
  20. Candeias, Emanuel. "Chronic antibiotic treatment induces neurodegenerative features through the mitochondria". Trabalho apresentado em 14th International Conference on AD/PD, 2019.
  21. Candeias, Emanuel. "Cortical neurons exposed to bacteria metabolites develop Alzheimer’s disease-related hallmarks". Trabalho apresentado em 14th International Conference on AD/PD, 2019.
  22. Candeias, Emanuel. "Mitochondria as a probable target of a bacterial neurotoxin: Relevance to Parkinson’ Disease etiology". Trabalho apresentado em 14th International Conference on AD/PD, 2019.
  23. Candeias, Emanuel. "Differential protein expression in diverse brain areas: Are Alzheimer’s and Parkinson’s disease brain specific?". Trabalho apresentado em 14th International Conference on AD/PD, 2019.
  24. Candeias, Emanuel. "A bacterial neurotoxin negatively impacts mitochondrial metabolism: microbial twist for PD etiology". Trabalho apresentado em International Symposium MitoPorto, 2018.
  25. Candeias, Emanuel. "Type 2 diabetes mellitus compromises the epididymal SIRT1/PGC-1a/SIRT3 axis predisposing to oxidative environment". Trabalho apresentado em I NoTeS Congress, 2018.
  26. Candeias, Emanuel. "The neurotoxin ß-Methylamino-L-Alanine (BMAA) acts on mitochondria to recapitulate PD-related pathology". Trabalho apresentado em 8th World Congress on Targeting Mitochondria, 2017.
  27. Candeias, Emanuel. "Peripheral exendin-4 treatment restores brain cortical glucose metabolism in type 2 diabetic rat". Trabalho apresentado em MitoPorto, 2017.
  28. Candeias, Emanuel. "Changes in brain glucose metabolism render middle-aged females less vulnerable to chronic Type 2 diabetes-related Alzheimer disease". Trabalho apresentado em XV Meeting of the Portuguese Society for Neuroscience, 2017.
  29. Candeias, Emanuel. "The dipeptidyl peptidase-4 inhibitor Linagliptin partially reverses striatal neuropathology in type 2 diabetic mice". Trabalho apresentado em SRP Diabetes Meeting, 2016.
  30. Candeias, Emanuel. "Glucose metabolism modulates gender-related diabetic brain susceptibility to Alzheimer disease-like neurodegeneration". Trabalho apresentado em Molecular Biology of Ageing Meeting, 2015.
  31. Candeias, Emanuel. "Actions of the anti-diabetic drug liraglutide in Alzheimer disease: brain glucose metabolism, neuroinflammation and cognition". Trabalho apresentado em XIV Meeting of the SPN, 2015.
  32. Candeias, Emanuel. "Exendin-4 therapy restores brain glucose homeostasis in type 2 diabetic Goto-Kakizaki rats: impact on neuroinflammation and oxidative stress". Trabalho apresentado em XIV Meeting of the SPN, 2015.
  33. Candeias, Emanuel. "Gender influences type 2 diabetic-related intracellular brain signaling and neurodegeneration markers". Trabalho apresentado em XIV Meeting of the SPN, 2015.
  34. Candeias, Emanuel. "Chronic peripheral administration of exendin-4: does it protect against brain dysfunction and cell death?". Trabalho apresentado em XIV Meeting of the SPN, 2015.
  35. Candeias, Emanuel. "Exendin-4-induced GLP-1 receptor signaling pathways restore autophagy and cognitive function and avoid Alzheimer disease like-hallmarks". Trabalho apresentado em 12th International Conference on Alzheimer’s & Parkinson’s Diseases (AD/PD), 2015.
  36. Candeias, Emanuel. "Peripheral liraglutide therapy counteracts Alzheimer’s disease-related brain changes". Trabalho apresentado em 12th International Conference on Alzheimer’s & Parkinson’s Diseases (AD/PD), 2015.
  37. Candeias, Emanuel. "Brain intracellular signaling, oxidative stress and Alzheimer’s disease-related hallmarks upon type 2 diabetes are differentially influenced by gender". Trabalho apresentado em 12th International Conference on Alzheimer’s & Parkinson’s Diseases (AD/PD), 2015.
  38. Candeias, Emanuel. "Peripherally-administered exendin-4 ameliorates type 2 diabetes-associated brain glucose dysmetabolism, neuroinflammation and oxidative stress". Trabalho apresentado em XVIII Congress of the Portuguese Biochemical Society (SPB), 2014.
  39. Candeias, Emanuel. "Chronic peripheral administration of exendin-4: is it advantageous against brain dysfunction and cell death?". Trabalho apresentado em XVIII Congress of the Portuguese Biochemical Society (SPB), 2014.
  40. Candeias, Emanuel. "Peripherally-administered exendin-4 ameliorates type 2 diabetes-associated brain glucose dysmetabolism, neuroinflammation and oxidative stress". Trabalho apresentado em XII CNC Annual Meeting, 2014.
  41. Candeias, Emanuel. "Type 2 diabetic female rat brains are less vulnerable to oxidative stress and AD-related hallmarks: a role for insulin/IGF-1/estrogen signaling?". Trabalho apresentado em XII CNC Annual Meeting, 2014.
  42. Candeias, Emanuel. "Chronic peripheral administration of exendin-4: is it advantageous against brain dysfunction and cell death?". Trabalho apresentado em XII CNC Annual Meeting, 2014.
  43. Candeias, Emanuel. "28. "Peripheral exendin-4 therapy restores brain glucagon-like peptide-1 receptor-mediated signaling pathways and glucose uptake and metabolism in type 2 diabetic Goto-Kakizaki rats". Trabalho apresentado em 9th FENS Forum of Neuroscience, 2014.
  44. Candeias, Emanuel. "Chronic peripheral exendin-4 administration protects against type 2 diabetes-associated rat brain apoptosis". Trabalho apresentado em 9th FENS Forum of Neuroscience, 2014.
  45. Candeias, Emanuel. "Type 2 diabetic female rat brains are less vulnerable to oxidative stress and AD-related hallmarks: a role for insulin/IGF-1/estrogen signaling?". Trabalho apresentado em 9th FENS Forum of Neuroscience, 2014.
  46. Candeias, Emanuel. "Gender modulates type 2 diabetes progression and development of Alzheimer disease-like hallmarks in adult rat brains". Trabalho apresentado em 4th PF2MUC Symposium, 2013.
  47. Candeias, Emanuel. "Alzheimer disease hallmarks in adult type 2 diabetic female rat brain: Is oxidative stress the predecessor?". Trabalho apresentado em 38th FEBS Congress, 2013.
  48. Candeias, Emanuel. "Gender effects in adult rat brains: Type 2 diabetes and Alzheimer disease hallmarks". Trabalho apresentado em 47th Annual Scientific Meeting of the European Society for Clinical Investigation, 2013.
  49. Candeias, Emanuel. "Type 2 diabetic female rats are less vulnerable to Alzheimer’s disease than males: the role of brain insulin/IGF-1 and estrogen". Trabalho apresentado em 11th International Conference on AD/PD, 2013.
  50. Candeias, Emanuel. "Oxidative damage in adult type 2 diabetic female rat brain precedes the development of Alzheimer disease features". Trabalho apresentado em Annual Sociedade Portuguesa Diabetologia (SPD) Meeting 2013, 2013.
  51. Candeias, Emanuel. "Type 2 diabetes-associated damage in aged rat brain: does gender matter?". Trabalho apresentado em 2nd PF2MUC Symposium, 2012.
  52. Candeias, Emanuel. "Brain damage in mature type 2 diabetic Goto-Kakizaki rat: does gender play a role?". Trabalho apresentado em 8th FENS Forum of Neuroscience, 2012.
  53. Candeias, Emanuel. "Type 2 diabetes-associated damage in aged rat brain: does gender matter?". Trabalho apresentado em 8th FENS Forum of Neuroscience, 2012.
  54. Candeias, Emanuel. "The role of gender in the brain of type 2 diabetic rats". Trabalho apresentado em 26th Meeting of GEECD, 2012.
  55. Candeias, Emanuel. "Impact of aging and chronic hypoxia on liver oxidative status". Trabalho apresentado em 5th Annual Meeting on Cell Signalling, 2011.
  56. Candeias, Emanuel. "Age-related oxidative imbalance in brains vessels is potentiated by chronic hypoxia". Trabalho apresentado em 5th Annual Meeting on Cell Signalling, 2011.
Resumo em conferência
  1. Munoz Pinto, Mario; Esteves, Ana Raquel; Magalhaes, Joao; Nunes-Costa, Daniela; Candeias, Emanuel; Silva, Diana; Alarico, Susana; et al. "Parkinson's disease neurodegeneration is mediated by the gut microbiome". Trabalho apresentado em European journal of Clinical Investigation, 2021.
Tese / Dissertação
  1. "The amazing anti-type 2 diabetic drugs in neurodegeneration: the impact of exendin-4, liraglutide and linagliptin in type 2 diabetes, Alzheimer disease and Parkinson disease". Doutoramento, Universidade de Coimbra Centro de Neurociências e Biologia Celular, 2021. http://hdl.handle.net/10316/98734.
  2. Candeias, Emanuel Monteiro. "Effect of age and chronic hypoxia on oxidative status, mitochondria and apoptosis in rat liver". Mestrado, 2011. http://hdl.handle.net/10316/25925.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2023/11/24 Voluntary oral administration as a refinement of studies in Parkinson Disease VIII National Symposium of Organizations Responsible for Animal Welfare (ORBEA)
rede ORBEA/SPCAL (Cantanhede, Portugal)
2023/05
FEBS (Luso, Portugal)
2019/05 The gut hypothesis for alzheimer's disease: Bacterial metabolites cause bioenergetic failure and activation of innate immunity in cortical neurons 53rd Annual Scientific Meeting of ESCI
ESCI (Coimbra, Portugal)
2018/05 The role of Mitochondria in Neuronal Innate Immunity Activation: Relevance for Parkinson´s Disease. 52nd Annual Scientific Meeting of ESCI
ESCI (Barcelona, Espanha)
2018/05 The hidden microbiome in Parkinson’s disease BIT’s 9th Annual World Congress of NeuroTalk
(Banguecoque, Tailândia)
2016/12 Chronic high fat diet consumption along with aging impairs the striatal pathway –Linagliptin neuroprotective effects SPB 2016, XIX National Congress of Biochemistry
SPB (Guimarães, Portugal)
2015/05 The anti-diabetic drug liraglutide rescues Alzheimer disease pathology in mature mice 29th Meeting of GEECD
GEECD (Aveiro, Portugal)
2015/05 Can peripheral administration of the anti-type 2 diabetic exendin-4 protect against brain dysfunction and apoptosis? 29th Meeting of GEECD
GEECD (Aveiro, Portugal)
2015/05 The role of gender on brain metabolism in middle-aged type 2 diabetic rats 29th Meeting of GEECD
GEECD (Aveiro, Portugal)
2014/12 Brain dysfunction upon chronic type 2 diabetes: the (neuro)protective effects of peripheral exendin-4 therapy XII CNC Annual Meeting
CNC (Coimbra, Portugal)
2014/06 Exendin-4 therapy in type 2 diabetic Goto-Kakizaki rats: impact in cognition, metabolism and Alzheimer disease hallmarks 28th Meeting of Grupo de Estudos em Envelhecimento Cerebral e Demência (GEECD)
Grupo de Estudos em Envelhecimento Cerebral e Demência (GEECD) (Aveiro, Portugal)
2014/06 Brain dysfunction and cell death in type 2 diabetes: Is the peripheral treatment with the anti-type 2 diabetic exendin-4 advantageous? 28th Meeting of GEECD
GEECD (Aveiro, Portugal)
2014/06 Gender and type 2 diabetes affect brain cortical intracellular signaling pathways, oxidative stress vulnerability and development of AD-related hallmarks 28th Meeting of GEECD
GEECD (Aveiro, Portugal)
2013/06 Adult female rat brain is less prone to Alzheimer disease hallmarks than male brains: the role of insulin/IGF-1 signaling XIII Annual Meeting of the Portuguese Society for Neurosciences (SPN)
SPN (Luso, Portugal)
2013/04 Type 2 diabetic female rats are less vulnerable to Alzheimer disease than males: the role of brain insulin/IGF-1 and estrogen 47th Annual Scientific Meeting of the European Society for Clinical Investigation
ESCI (Albufeira, Portugal)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2022 - 2022 Mitochondrial network complexity in the Dorsal Motor of the Vagus Nerve of an animal model of Parkinson's disease
Orientador
 Biology (Licenciatura/Bacharelato)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2023 - 2023 Semana da Ciência e da Tecnologia 2023 (SCT2023)
2022 - 2022 European Researchers’ Night 2022
2018/11 - 2018/11 Semana da Ciência e da Tecnologia 2018 (SCT2018) Semana da Ciência e da Tecnologia 2018 (SCT2018)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018/09/28 - 2018/09/28 European Researchers’ Night 2018 European Researchers’ Night 2018
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2015/02 - 2015/02 Institute of Education and Citizenship (IEC) Courses 2015 Institute of Education and Citizenship (IEC) Courses 2015
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2014/09 - 2014/09 European Researchers’ Night 2014 European Researchers’ Night 2014
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2014/08 - 2014/08 Ciência Viva Summer Internships 2014 Ciência Viva Summer Internships 2014
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2014/03 - 2014/03 Brain Awareness Week 2014 Brain Awareness Week 2014
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013/09 - 2013/09 European Researchers’ Night 2013 European Researchers’ Night 2013
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013/07 - 2013/07 Ciência Viva Summer Internships 2013 Ciência Viva Summer Internships 2013
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2016/05 - 2016/09 Journal of Alzheimer's Disease (JAD) ( 1875-8908) IOS Press

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2022 - Atual Biologia do Envelhecimento - Engenharia Biomédica (Mestrado integrado) Biologia do Envelhecimento Universidade de Coimbra, Portugal

Membro de associação

Nome da associação Tipo de participação
2023 - Atual PostDoc CIBB Representative, Center for Innovative Biomedicine and Biotechnology (CIBB) University of Coimbra, Portugal
Distinções

Prémio

2021 Best Poster Award, Session Basis Research in the 55th Annual Scientific Meeting of the European Society for Clinical Investigation, 9-11 June 2021, Online Event (co-author)
2019 Poster Award 2019, for outstanding presentation of important scientific work in the field of Neurobiology of Aging. 53rd Annual Scientific Meeting of ESCI. May 22-24, 2019, Coimbra, Portugal.
European Society for Clinical Investigation, Países Baixos
2019 ESCI travel grant for participating in the 53rd Annual Scientific Meeting of ESCI in Coimbra, Portugal. May 22-24, 2019.
European Society for Clinical Investigation, Países Baixos
2016 Portuguese Biochemistry Society (SPB) Student Scholarship to attend the XIX National Congress of Biochemistry (SPB2016), December 8-10, 2016, Guimarães, Portugal.
Sociedade Portuguesa de Bioquímica, Portugal
2014 Poster Award 3rd, XII CNC Annual Meeting, December 15-16, 2014, Coimbra, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2014 Sociedade Portuguesa de Neurociências (SPN) 2014 Fellowship for participation in FENS Congress 2014, July 5-9, 2014, Milan, Italy.
2013 European Society for Clinical Investigation (ESCI) 2013 Travel Grant for participation in ESCI Meeting 2013, April 17-20, 2013, Albufeira, Portugal.
European Society for Clinical Investigation, Países Baixos
2013 Federation of European Biochemical Societies (FEBS) 2013 Bursary for participation in FEBS Congress 2013, July 3-11, 2013, S. Petersburg, Russia.
Federation of European Biochemical Societies, Reino Unido