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Vera Mónica Milheirão Mendes. Concluiu o(a) Mestrado em Master degree in Chemistry- Specialization area on Quality Control and Environment em 2009 pelo(a) Universidade de Coimbra Faculdade de Ciencias e Tecnologia e Licenciatura em Química ( Ramo dos Processos Biológicos) em 2006 pelo(a) Universidade de Coimbra Faculdade de Ciencias e Tecnologia. É Técnico Superior de 2ª classe (Cromatografia bidimensional e espectrometria de massa) no(a) CNC.IBILI. Publicou 14 artigos em revistas especializadas. No seu currículo Ciência Vitae os termos mais frequentes na contextualização da produção científica, tecnológica e artístico-cultural são: actinorhizal plants; Casuarina glauca; Frankia; proteomics; salt stress; .
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Identificação

Identificação pessoal

Nome completo
Vera Mónica Milheirão Mendes

Nomes de citação

  • Mendes, Vera M

Identificadores de autor

Ciência ID
9311-D531-5607
ORCID iD
0000-0002-4593-673X

Moradas

  • Center for Neuroscience and Cell Biology, University of Coimbra. UC Biotech - Parque Tecnológico de Cantanhede, Núcleo 04, Lote 8, 3060-197 , Cantanhede, Cantanhede, Portugal (Profissional)

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Francês Utilizador elementar (A1) Utilizador elementar (A2) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1)
Inglês Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1)
Formação
Grau Classificação
2009
Concluído
 Master degree in Chemistry- Specialization area on Quality Control and Environment (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Low Molecular Weight Biomarkers in Multiple Sclerosis - Development and validation of a multivariate analysis workflow" (TESE/DISSERTAÇÃO)
 17
2006
Concluído
 Química (Licenciatura)
Especialização em Processos Biológicos
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"“Development and validation of an HPLC method for quantification of GABA from rat brain dialisate samples” " (TESE/DISSERTAÇÃO)
 14
Percurso profissional

Outras Carreiras

Categoria Profissional
Instituição de acolhimento 		Empregador
2008 - Atual Técnico Superior (Técnico Superior) CNC.IBILI, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2007/07/01 - 2008/06/30 Bolseiro técnico de Investigação (Cromatografia bidimensional e espectrometria de massa) CNC.IBILI, Portugal
2005 - 2006 Estagiário Universidade de Coimbra Faculdade de Medicina, Portugal
Projetos

Projeto

Designação Financiadores
2018/09/01 - 2021/08/31 Beyond Beta-Amyloid - Deciphering Early Pathogenic Changes in Alzheimer's disease
PTDC/MED-NEU/27946/2017
2018/07/26 - 2021/07/25 Affective disorders: biomarkers and early detection
PTDC/MEC-PSQ/30943/2017
Em curso
2018/06/01 - 2021/05/31 New approaches on Hypoxic-Ischemic Encephalopathy: translational research to diagnose and monitor stem cell therapy
PTDC/BTM-TEC/29311/2017
Em curso
2017/02/01 - 2021/01/31 Synaptic networks and Personalized Medicine Approaches to Understand Neurobehavioural Diseases Across the Lifespan
SAICTPAC/0010/2015
2013/06 - 2016/05 Anticipating diabetes and diabetic wounding for siblings of Type 2 diabetics.
124979
Provided by PTCRIS: 124979
 Fundação para a Ciência e a Tecnologia, I.P.
2013/05 - 2015/04 DJ-1 neuronal rescue under oxidative stress: implications for Parkinson's disease
124354
Provided by PTCRIS: 124354
 Fundação para a Ciência e a Tecnologia, I.P.
2010/09 - 2013/12 Molecular Mechanisms of Synaptic Traffic of Glutamate Receptors of the NMDA Type
99440
Provided by PTCRIS: 99440
 Fundação para a Ciência e a Tecnologia, I.P.
2010/04 - 2013/09 Optimizing carbohydrate utilization in farmed sea-bass through metabolic profiling
Provided by PTCRIS: 98111
98111
 Fundação para a Ciência e a Tecnologia, I.P.
2010/04 - 2013/07 Retroviral-like membrane-associated aspartic proteinases from Rickettsiae: potential new therapeutic targets for rickettsioses.
107942
Provided by PTCRIS: 107942
 Fundação para a Ciência e a Tecnologia, I.P.
2010/03 - 2013/07 Analysis of the hippocampal proteome in mice exposed to psychotropic medication
Provided by PTCRIS: 103728
103728
 Fundação para a Ciência e a Tecnologia, I.P.
Produções

Publicações

Artigo em revista
  1. Moutinho, Daniela; Mendes, Vera M.; Caula, Alessandro; Madeira, Sara C.; Baldeiras, Inês; Guerreiro, Manuela; Cardoso, Sandra; et al. "Pathophysiological subtypes of mild cognitive impairment due to Alzheimer’s disease identified by CSF proteomics". Translational Neurodegeneration 13 1 (2024): http://dx.doi.org/10.1186/s40035-024-00412-1.
    10.1186/s40035-024-00412-1
  2. Santa C; Rodrigues D; Coelho JF; Anjo SI; Mendes VM; Bessa-Neto D; Dunn MJ; et al. "Chronic treatment with D2-antagonist haloperidol leads to inhibitory/excitatory imbalance in striatal D1-neurons.". Translational psychiatry (2023): http://europepmc.org/abstract/med/37803004.
    10.1038/s41398-023-02609-w
  3. Cátia Sofia Leite Pereira; Ander Castander-Olarieta; Itziar Aurora Montalbán; Mendes VM; Sandra Correia; Ana Pedrosa; Bruno Manadas; Paloma Moncaleán; Jorge Canhoto. "Proteomic and Metabolic Analysis of Pinus halepensis Mill. Embryonal Masses Induced under Heat Stress". International journal of molecular sciences (2023): https://europepmc.org/articles/PMC10139065.
    10.3390/ijms24087211
  4. Margarida Coelho; Rohit Mahar; Getachew D. Belew; Alejandra Torres; Cristina Barosa; Fernando Cabral; Ivan Viegas; et al. "Enrichment of hepatic glycogen and plasma glucose from H218O informs gluconeogenic and indirect pathway fluxes in naturally feeding mice". NMR in Biomedicine (2023): https://doi.org/10.1002/nbm.4837.
    10.1002/nbm.4837
  5. Esteves E; Mendes VM; Bruno Manadas; Lopes R; Liliana Bernardino; Maria Correia; Marlene Barros; Ana Cristina Esteves; Nuno Rosa. "COVID-19 Salivary Protein Profile: Unravelling Molecular Aspects of SARS-CoV-2 Infection.". Journal of clinical medicine (2022): https://europepmc.org/articles/PMC9570692.
    10.3390/jcm11195571
  6. Fábio Trindade; Ana Filipa Ferreira; Francisca Saraiva; Martins D; Mendes VM; Carla Sousa; Cristina Gavina; et al. "Optimization of a Protocol for Protein Extraction from Calcified Aortic Valves for Proteomics Applications: Development of a Standard Operating Procedure.". Proteomes (2022): https://europepmc.org/articles/PMC9505568.
    10.3390/proteomes10030030
  7. Bebianno MJ; Mendes VM; O'Donovan S; Carteny CC; Keiter S; Bruno Manadas. "Effects of microplastics alone and with adsorbed benzo(a)pyrene on the gills proteome of Scrobicularia plana.". The Science of the total environment (2022): https://doi.org/10.1016/j.scitotenv.2022.156895.
    10.1016/j.scitotenv.2022.156895
  8. Ander Castander-Olarieta; Pereira C; Mendes VM; Sandra Correia; Bruno Manadas; Jorge Canhoto; Montalbán IA; Moncaleán P. "Thermopriming-associated proteome and sugar content responses in Pinus radiata embryogenic tissue.". Plant science : an international journal of experimental plant biology (2022): https://doi.org/10.1016/j.plantsci.2022.111327.
    10.1016/j.plantsci.2022.111327
  9. Salazar, Ivan L.; Lourenço, Ana S. T.; Manadas, Bruno; Baldeiras, Inês; Ferreira, Cláudia; Teixeira, Anabela Claro; Mendes, Vera M.; et al. "Posttranslational modifications of proteins are key features in the identification of CSF biomarkers of multiple sclerosis". Journal of Neuroinflammation 19 1 (2022): http://dx.doi.org/10.1186/s12974-022-02404-2.
    10.1186/s12974-022-02404-2
  10. Mendes, Vera. "The Enhanced Efficacy of Intracellular Delivery of Doxorubicin/C6-Ceramide Combination Mediated by the F3 Peptide/Nucleolin System Is Supported by the Downregulation of the PI3K/Akt Pathway". Cancers 13 12 (2021): 3052-3052. http://dx.doi.org/10.3390/cancers13123052.
    10.3390/cancers13123052
  11. Mendes, Vera. "Proteome-Wide Analysis of Heat-Stress in Pinus radiata Somatic Embryos Reveals a Combined Response of Sugar Metabolism and Translational Regulation Mechanisms". Frontiers in Plant Science 12 (2021): http://dx.doi.org/10.3389/fpls.2021.631239.
    10.3389/fpls.2021.631239
  12. Fonseca, Nuno A.; Gregório, Ana C.; Mendes, Vera M.; Lopes, Rui; Abreu, Teresa; Gonçalves, Nélio; Manadas, Bruno; et al. "GMP-grade nanoparticle targeted to nucleolin downregulates tumor molecular signature, blocking growth and invasion, at low systemic exposure". Nano Today 37 (2021): 101095. http://dx.doi.org/10.1016/j.nantod.2021.101095.
    Publicado • 10.1016/j.nantod.2021.101095
  13. Rodrigo, Ana P.; Mendes, Vera M.; Manadas, Bruno; Grosso, Ana R.; Alves de Matos, António P.; Baptista, Pedro V.; Costa, Pedro M.; Fernandes, Alexandra R.. "Specific Antiproliferative Properties of Proteinaceous Toxin Secretions from the Marine Annelid Eulalia sp. onto Ovarian Cancer Cells". Marine Drugs 19 1 (2021): 31. http://dx.doi.org/10.3390/md19010031.
    Publicado • 10.3390/md19010031
  14. Abrantes Dias, Ana Sofia; Amaral Pinto, Joana Catarina; Magalhães, Mariana; Mendes, Vera M.; Manadas, Bruno. "Analytical methods to monitor dopamine metabolism in plasma: Moving forward with improved diagnosis and treatment of neurological disorders". Journal of Pharmaceutical and Biomedical Analysis 187 (2020): 113323. http://dx.doi.org/10.1016/j.jpba.2020.113323.
    Publicado • 10.1016/j.jpba.2020.113323
  15. Francisca A. de Leeuw; Wiesje M. van der Flier; Betty M. Tijms; Philip Scheltens; Vera M. Mendes; Bruno Manadas; Jörgen Bierau; et al. "Specific Nutritional Biomarker Profiles in Mild Cognitive Impairment and Subjective Cognitive Decline Are Associated With Clinical Progression: The NUDAD Project". Journal of the American Medical Directors Association (2020): https://doi.org/10.1016/j.jamda.2019.12.009.
    10.1016/j.jamda.2019.12.009
  16. Graça, Inês; Mendes, Vera M.; Marques, Isabel; Duro, Nuno; Costa, Mário; Ramalho, José C.; Pawlowski, Katharina; et al. "Comparative proteomic analysis of nodulated and non-nodulated Casuarina glauca Sieb. ex Spreng. grown under salinity conditions using sequential window acquisition of all theoretical mass spectra (SWATH-MS)". (2020): http://hdl.handle.net/10400.5/19224.
    10.3390/ijms21010078
  17. Willemse, Eline A.J.; Vermeiren, Yannick; Garcia-Ayllon, Maria-Salud; Bridel, Claire; De Deyn, Peter P.; Engelborghs, Sebastiaan; van der Flier, Wiesje M.; et al. "Pre-analytical stability of novel cerebrospinal fluid biomarkers". Clinica Chimica Acta 497 (2019): 204-211. http://dx.doi.org/10.1016/j.cca.2019.07.024.
    10.1016/j.cca.2019.07.024
  18. Mendes, Vera M.; Coelho, Margarida; Tomé, Angelo R.; Cunha, Rodrigo A.; Manadas, Bruno. "Validation of an LC-MS/MS Method for the Quantification of Caffeine and Theobromine Using Non-Matched Matrix Calibration Curve". Molecules 24 16 (2019): 2863. http://dx.doi.org/10.3390/molecules24162863.
    10.3390/molecules24162863
  19. Diana Barros; Arunava Pradhan; Vera M. Mendes; Bruno Manadas; Pedro M. Santos; Cláudia Pascoal; Fernanda Cássio. "Proteomics and antioxidant enzymes reveal different mechanisms of toxicity induced by ionic and nanoparticulate silver in bacteria". Environmental Science: Nano (2019): https://doi.org/10.1039/C8EN01067F.
    10.1039/C8EN01067F
  20. Coelho, Margarida; Mendes, Vera M.; Lima, Ines S.; Martins, Fatima O.; Fernandes, Ana B.; Paula Macedo, M.; Jones, John G.; Manadas, Bruno. "Direct analysis of [6,6-H-2(2)]glucose and [U-C-13(6)]glucose dry blood spot enrichments by LC-MS/MS". Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 1022 (2016): 242-248. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000376545800032&KeyUID=WOS:000376545800032.
    10.1016/j.jchromb.2016.04.027
  21. Freitas, Marisa; Azevedo, Joana; Carvalho, Antonio Paulo; Mendes, Vera M.; Manadas, Bruno; Campos, Alexandre; Vasconcelos, Vitor. "Bioaccessibility and changes on cylindrospermopsin concentration in edible mussels with storage and processing time". Food Control 59 (2016): 567-574. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000364890000075&KeyUID=WOS:000364890000075.
    10.1016/j.foodcont.2015.06.025
  22. Rosa, Nuno; Marques, Jessica; Esteves, Eduardo; Fernandes, Monica; Mendes, Vera M.; Afonso, Angela; Dias, Sergio; et al. "Protein Quality Assessment on Saliva Samples for Biobanking Purposes". Biopreservation and Biobanking 14 4 (2016): 289-297. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000382510300005&KeyUID=WOS:000382510300005.
    10.1089/bio.2015.0054
  23. Travassos M; Santana I; Baldeiras I; Tsolaki M; Gkatzima O; Sermin G; Yener GG; et al. "Does Caffeine Consumption Modify Cerebrospinal Fluid Amyloid-ß Levels in Patients with Alzheimer's Disease?". (2015): http://europepmc.org/abstract/med/26401784.
    10.3233/JAD-150374
  24. Mendes, Vera. "Analysis of Citalopram in Plasma and Hair by a Validated LC–MS/MS Method.". Journal of Chromatography & Separation Techniques (2015):
    10.4172/2157-7064.1000274
  25. Coelho M; Nunes P; Mendes VM; Manadas B; Heerschap A; Jones JG. "Effect of Global ATGL Knockout on Murine Fasting Glucose Kinetics.". (2015): http://europepmc.org/abstract/med/26236747.
    10.1155/2015/542029
  26. Soares-dos-Reis R; Pessoa AS; Matos MR; Falcão M; Mendes VM; Manadas B; Monteiro FA; Lima D; Reguenga C. "Ser¹¹¿ phosphorylation modulates the activity and conformation of PRRXL1, a homeodomain transcription factor.". (2014): http://europepmc.org/abstract/med/24564673.
    10.1042/BJ20131014
  27. Viegas I; Mendes VM; Leston S; Jarak I; Carvalho RA; Pardal MÂ; Manadas B; Jones JG. "Analysis of glucose metabolism in farmed European sea bass (Dicentrarchus labrax L.) using deuterated water.". (2011): http://europepmc.org/abstract/med/21777686.
    10.1016/j.cbpa.2011.06.029
  28. Vinhas R; Cortes L; Cardoso I; Mendes VM; Manadas B; Todo-Bom A; Pires E; Veríssimo P. "Pollen proteases compromise the airway epithelial barrier through degradation of transmembrane adhesion proteins and lung bioactive peptides.". (2011): http://europepmc.org/abstract/med/21480927.
    10.1111/j.1398-9995.2011.02598.x
  29. Manadas B; Mendes VM; English J; Dunn MJ. "Peptide fractionation in proteomics approaches.". (2010): http://europepmc.org/abstract/med/20973639.
    10.1586/epr.10.46
  30. Pereira FC; Rolo MR; Marques E; Mendes VM; Ribeiro CF; Ali SF; Morgadinho T; Macedo TR. "Acute increase of the glutamate-glutamine cycling in discrete brain areas after administration of a single dose of amphetamine.". (2008): http://europepmc.org/abstract/med/18991867.
    10.1196/annals.1432.040
Capítulo de livro
  1. Mendes, Vera M.; Coelho, Margarida; Manadas, Bruno. "Untargeted Metabolomics Relative Quantification by SWATH Mass Spectrometry Applied to Cerebrospinal Fluid". In Cerebrospinal Fluid (CSF) Proteomics, 321-336. Springer New York, 2019.
    Publicado • 10.1007/978-1-4939-9706-0_20
  2. Santa, Cátia; Anjo, Sandra I.; Mendes, Vera M.; Manadas, Bruno. "Neuroproteomics — LC-MS Quantitative Approaches". In Recent Advances in Proteomics Research. InTech, 2015.
    Publicado • 10.5772/61298
Poster em conferência
  1. Mendes, Vera M; Sabala, Lúcia; Manadas, Bruno. "Finding interesting oxidative stress related molecules by an untargeted liquid chromatography-mass spectrometry approach". Trabalho apresentado em XVIII Congress of the Portuguese Biochemical Society, 2014.
  2. Mendes, Vera; Jones, John; Macedo, Paula; A. Fernandes; Manadas, Bruno. "Analysis of glucose enrichment from a double tracer meal tolerance test by LC-MS". Trabalho apresentado em 47th EASD Annual Meeting, 2011.
  3. Mendes, Vera; Ivan Viegas; Ivana Jarak; John Jones; Manadas, Bruno. "Quantification of plasma glucose deuterium enrichment by tandem mass spectrometry". Trabalho apresentado em 59th ASMS Conference on Mass Spectrometry and Allied Topics, 2011.
  4. Mendes, Vera; Ana S.T. Lourenço; Manadas, Bruno; Inês Baldeiras; Sónia Batista; Mário Grãos; Lívia Sousa; et al. "Finding potential biomarkers of Multiple Sclerosis by a label-free LC-MS approach". Trabalho apresentado em 58th ASMS Conference on Mass Spectrometry and Allied Topics, 2010.
  5. Mendes, Vera; Ana S.T. Lourenço; Bruno Manadas; Inês Baldeiras; Sónia Batista; Mário Grãos; Lívia Sousa; et al. "Label free quantification of low molecular weight biomolecules by LC-MS for biomarker discovery in multiple sclerosis". Trabalho apresentado em 5th Congress of the Portuguese Proteomics Network – ProCura, and 1st International Congress on Analytical Proteomics – ICAP, 2009.
  6. Mendes, Vera; MT Morgadinho; J.Silva; F.Pereira; TRA Macedo. "Cromatografia Líquida na Determinação de GABA em Dialisados e Tecido Cerebral de Rato". Trabalho apresentado em V Congresso de Investigação em Medicina, 2006.
Atividades

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2017/04/28 - Atual Como escolher a técnica estatística mais adequada?
Universidade de Coimbra Faculdade de Medicina, Portugal
2012/12/10 - Atual Alternatives to animal use in pre-clinical studies workshop
Seminário
Biocant Associação de Transferência de Tecnologia, Portugal
2019/05/06 - 2019/05/10 Proteomics Approaches in Life Sciences
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018/02/12 - 2018/03/24 Gestão e Marketing – Princípios básicos
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018/02/05 - 2018/02/08 From Protein Structure to Biological Function Through Interactomics: an integrated View, 2nd Edition
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2017/09/20 - 2018/01/12 Plataforma de gestão da qualidade UeBe.Q
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2015/09/07 - 2015/09/11 From Protein Structure to Biological Function Through Interactomics: an integrated View
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2014/03/15 - 2014/04/05 SPSS advanced- Multivariate data analysis
Universidade de Coimbra Faculdade de Economia, Portugal
2013/10/19 - 2013/12/07 Statistical data analysis by SPSS
Universidade de Coimbra Faculdade de Economia, Portugal
2012/11 - 2012/11 Good Laboratory Practices
Biocant Associação de Transferência de Tecnologia, Portugal
2010/05/23 - 2010/05/23 Metabolomics short course 58th ASMS Conference on Mass Spectrometry and Allied Topics
2009/07/09 - 2009/07/09 Mass Spectrometry Workshop: An interdisciplinary approach Mass Spectrometry Workshop: An interdisciplinary approach
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal