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Identificação

Identificação pessoal

Nome completo
James Moir

Nomes de citação

  • Moir, James

Identificadores de autor

Ciência ID
971B-A475-C3C4
ORCID iD
0000-0003-2972-5235
Formação
Grau Classificação
1990/10 - 1993/10
Concluído
Biochemistry (Doktor (PhD))
University of Oxford Wadham College, Reino Unido
1986/10 - 1990/06
Concluído
Biochemistry (Bachelor)
University of Oxford Wadham College, Reino Unido
2:1
Percurso profissional

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento
Empregador
2016/10 - 2050 Professor Catedrático (Docente Universitário) University of York Department of Biology, Reino Unido
Produções

Publicações

Artigo em revista
  1. Víctor Castro-Gutiérrez; Edward Fuller; John C. Thomas; Chris J. Sinclair; Steven Johnson; Thorunn Helgason; James W.B. Moir. "Genomic basis for pesticide degradation revealed by selection, isolation and characterisation of a library of metaldehyde-degrading strains from soil". Soil Biology and Biochemistry 142 (2020): 107702-107702. https://doi.org/10.1016/j.soilbio.2019.107702.
    10.1016/j.soilbio.2019.107702
  2. Jonathan S. Ward; Alice De Palo; Benjamin J. Aucott; James W. B. Moir; Jason M. Lynam; Ian J. S. Fairlamb. "A biotin-conjugated photo-activated CO-releasing molecule (biotinCORM): efficient CO-release from an avidin–biotinCORM protein adduct". Dalton Transactions (2019): https://doi.org/10.1039/C9DT03429C.
    10.1039/C9DT03429C
  3. Moir, James. "Isolation and characterization of metaldehyde-degrading bacteria from domestic soils.". Microbial biotechnology (2017): http://europepmc.org/abstract/med/28707368.
    10.1111/1751-7915.12719
  4. Moir, James. "Microbial changes linked to the accelerated degradation of the herbicide atrazine in a range of temperate soils.". Environmental science and pollution research international (2017): http://europepmc.org/abstract/med/28108915.
    10.1007/s11356-017-8377-y
  5. Jonathan S. Ward; Rebecca Morgan; Jason M. Lynam; Ian J. S. Fairlamb; James W. B. Moir. "Toxicity of tryptophan manganese(i) carbonyl (Trypto-CORM), against Neisseria gonorrhoeae". MedChemComm 8 2 (2017): 346-352. https://doi.org/10.1039/C6MD00603E.
    10.1039/C6MD00603E
  6. Moir, James. "Re-engineering a NiFe hydrogenase to increase the H2 production bias while maintaining native levels of O2 tolerance.". Chemical communications (Cambridge, England) (2016): http://europepmc.org/abstract/med/27055899.
    10.1039/c6cc00515b
  7. Moir, James. "Cytochrome c-based domain modularity governs genus-level diversification of electron transfer to dissimilatory nitrite reduction.". Environmental microbiology (2015): http://europepmc.org/abstract/med/25330335.
    10.1111/1462-2920.12661
  8. Moir, James. "Erratum to: Lipid-modified azurin of Neisseria meningitidis is a copper protein localized on the outer membrane surface and not regulated by FNR.". Antonie van Leeuwenhoek (2015): http://europepmc.org/abstract/med/25753538.
    10.1007/s10482-015-0420-8
  9. Moir, James. "Meningitis in adolescents: the role of commensal microbiota.". Trends in microbiology (2015): http://europepmc.org/abstract/med/25818619.
    10.1016/j.tim.2015.02.004
  10. Moir, James. "Lipid-modified azurin of Neisseria meningitidis is a copper protein localized on the outer membrane surface and not regulated by FNR.". Antonie van Leeuwenhoek (2015): http://europepmc.org/abstract/med/25666376.
    10.1007/s10482-015-0400-z
  11. Moir, James. "Confocal and fluorescence lifetime imaging sheds light on the fate of a pyrene-tagged carbon monoxide-releasing Fischer carbene chromium complex.". Dalton transactions (Cambridge, England : 2003) (2015): http://europepmc.org/abstract/med/25553721.
    10.1039/c4dt03312d
  12. Moir, James. "Visible-light-induced CO release from a therapeutically viable tryptophan-derived manganese(I) carbonyl (TryptoCORM) exhibiting potent inhibition against E. coli.". Chemistry (Weinheim an Der Bergstrasse, Germany) (2014): http://europepmc.org/abstract/med/25279824.
    10.1002/chem.201403305
  13. Moir, James. "A large genomic island allows Neisseria meningitidis to utilize propionic acid, with implications for colonization of the human nasopharynx.". Molecular microbiology (2014): http://europepmc.org/abstract/med/24910087.
    10.1111/mmi.12664
  14. Moir, James. "Pro-inflammatory cytokines can act as intracellular modulators of commensal bacterial virulence.". Open biology (2013): http://europepmc.org/abstract/med/24107297.
    10.1098/rsob.130048
  15. Moir, James. "The novel NhaE-type Na(+)/H (+) antiporter of the pathogenic bacterium Neisseria meningitidis.". Archives of microbiology (2013): http://europepmc.org/abstract/med/23208205.
    10.1007/s00203-012-0856-4
  16. Moir, James. "A therapeutically viable photo-activated manganese-based CO-releasing molecule (photo-CO-RM).". Dalton transactions (Cambridge, England : 2003) (2012): http://europepmc.org/abstract/med/22850731.
    10.1039/c2dt31588b
  17. Moir, James. "Neisseria meningitidis and Neisseria gonorrhoeae are differently adapted in the regulation of denitrification: single nucleotide polymorphisms that enable species-specific tuning of the aerobic-anaerobic switch.". The Biochemical journal (2012): http://europepmc.org/abstract/med/22509901.
    10.1042/bj20111984
  18. Moir, James. "A snapshot of a pathogenic bacterium mid-evolution: Neisseria meningitidis is becoming a nitric oxide-tolerant aerobe.". Biochemical Society transactions (2011): http://europepmc.org/abstract/med/22103546.
    10.1042/bst20110735
  19. Moir, James. "Tied down: tethering redox proteins to the outer membrane in Neisseria and other genera.". Biochemical Society transactions (2011): http://europepmc.org/abstract/med/22103547.
    10.1042/bst20110736
  20. Moir, James. "A sweet killer: mesoporous polysaccharide confined silver nanoparticles for antibacterial applications.". International journal of molecular sciences (2011): http://europepmc.org/abstract/med/22016626.
    10.3390/ijms12095782
  21. Moir, James. "Structural alterations in a component of cytochrome c oxidase and molecular evolution of pathogenic Neisseria in humans.". PLoS Pathogens (2010): http://europepmc.org/abstract/med/20808844.
    10.1371/journal.ppat.1001055
  22. Moir, James. "Binding to DNA protects Neisseria meningitidis fumarate and nitrate reductase regulator (FNR) from oxygen.". The Journal of biological chemistry (2010): http://europepmc.org/abstract/med/19917602.
    10.1074/jbc.m109.057810
  23. Moir, James. "Bacterial nitric oxide detoxification prevents host cell S-nitrosothiol formation: a novel mechanism of bacterial pathogenesis.". The FASEB Journal (2010): http://europepmc.org/abstract/med/19720623.
    10.1096/fj.08-128330
  24. Moir, James. "The X-ray crystal structure of an Arthrobacter protophormiae endo-beta-N-acetylglucosaminidase reveals a (beta/alpha)(8) catalytic domain, two ancillary domains and active site residues key for transglycosylation activity.". Journal of molecular biology (2009): http://europepmc.org/abstract/med/19327363.
    10.1016/j.jmb.2009.03.050
  25. Moir, James. "Interdependence of two NarK domains in a fused nitrate/nitrite transporter.". Molecular microbiology (2008): http://europepmc.org/abstract/med/18823285.
    10.1111/j.1365-2958.2008.06436.x
  26. Moir, James. "Enhanced glycosylation with mutants of endohexosaminidase A (endo A).". Chembiochem : a European journal of chemical biology (2008): http://europepmc.org/abstract/med/18677737.
    10.1002/cbic.200800214
  27. Moir, James. "Roles of c-type cytochromes in respiration in Neisseria meningitidis.". Microbiology (Reading, England) (2008): http://europepmc.org/abstract/med/18757819.
    10.1099/mic.0.2008/020339-0
  28. Moir, James. "The nitric oxide (NO)-sensing repressor NsrR of Neisseria meningitidis has a compact regulon of genes involved in NO synthesis and detoxification.". Journal of bacteriology (2008): http://europepmc.org/abstract/med/18245279.
    10.1128/jb.01869-07
  29. Moir, James. "Measuring nitric oxide metabolism in the pathogen Neisseria meningitidis.". Methods in enzymology (2008): http://europepmc.org/abstract/med/18433646.
    10.1016/s0076-6879(07)37027-4
  30. Moir, James. "Endohexosaminidase-catalysed glycosylation with oxazoline donors: fine tuning of catalytic efficiency and reversibility.". Chemistry (Weinheim an Der Bergstrasse, Germany) (2008): http://europepmc.org/abstract/med/18537207.
    10.1002/chem.200800365
  31. Moir, James. "Delivery of nitric oxide for analysis of the function of cytochrome c'.". Methods in enzymology (2008): http://europepmc.org/abstract/med/18237625.
    10.1016/s0076-6879(08)36002-9
  32. Moir, James. "Metabolism of nitric oxide by Neisseria meningitidis modifies release of NO-regulated cytokines and chemokines by human macrophages.". Microbes and infection (2007): http://europepmc.org/abstract/med/17544805.
    10.1016/j.micinf.2007.04.002
  33. Moir, James. "Regulation of denitrification genes in Neisseria meningitidis by nitric oxide and the repressor NsrR.". Journal of bacteriology (2007): http://europepmc.org/abstract/med/17122348.
    10.1128/jb.01368-06
  34. Moir, James. "Expression and characterisation of a major c-type cytochrome encoded by gene kustc0563 from Kuenenia stuttgartiensis as a recombinant protein in Escherichia coli.". Protein expression and purification (2007): http://europepmc.org/abstract/med/17049265.
    10.1016/j.pep.2006.06.026
  35. Moir, James. "Endohexosaminidase M: exploring and exploiting enzyme substrate specificity.". Chembiochem : a European journal of chemical biology (2006): http://europepmc.org/abstract/med/16800015.
    10.1002/cbic.200600183
  36. Moir, James. "Synthesis of N-glycan oxazolines: donors for endohexosaminidase catalysed glycosylation.". Carbohydrate research (2006): http://europepmc.org/abstract/med/16584712.
    10.1016/j.carres.2006.03.007
  37. Moir, James. "Heterologous overexpression and purification of cytochrome c' from Rhodobacter capsulatus and a mutant (K42E) in the dimerization region. Mutation does not alter oligomerization but impacts the heme iron spin state and nitric oxide binding properties.". Biochemistry (2006): http://europepmc.org/abstract/med/16584174.
    10.1021/bi052605j
  38. Moir, James. "Effect of combined oxidative and nitrosative stress on Neisseria meningitidis.". Biochemical Society transactions (2006): http://europepmc.org/abstract/med/16417521.
    10.1042/bst0340197
  39. Moir, James. "Organization of the respiratory chain of Neisseria meningitidis.". Biochemical Society transactions (2006): http://europepmc.org/abstract/med/16417504.
    10.1042/bst0340139
  40. Moir, James. "Inhibition of macrophage apoptosis by Neisseria meningitidis requires nitric oxide detoxification mechanisms.". Infection and immunity (2006): http://europepmc.org/abstract/med/16369030.
    10.1128/iai.74.1.729-733.2006
  41. Moir, James. "The pathogen Neisseria meningitidis requires oxygen, but supplements growth by denitrification. Nitrite, nitric oxide and oxygen control respiratory flux at genetic and metabolic levels.". Molecular microbiology (2005): http://europepmc.org/abstract/med/16238628.
    10.1111/j.1365-2958.2005.04866.x
  42. Moir, James. "Mutational and biochemical analysis of cytochrome c', a nitric oxide-binding lipoprotein important for adaptation of Neisseria gonorrhoeae to oxygen-limited growth.". The Biochemical journal (2005): http://europepmc.org/abstract/med/15689189.
    10.1042/bj20041766
  43. Moir, James. "Nitric oxide detoxification systems enhance survival of Neisseria meningitidis in human macrophages and in nasopharyngeal mucosa.". Infection and immunity (2005): http://europepmc.org/abstract/med/15908358.
    10.1128/iai.73.6.3322-3329.2005
  44. Moir, James. "Accessibility of the distal heme face, rather than Fe-His bond strength, determines the heme-nitrosyl coordination number of cytochromes c': evidence from spectroscopic studies.". Biochemistry (2005): http://europepmc.org/abstract/med/15952773.
    10.1021/bi050428g
  45. Moir, James. "Microaerobic denitrification in Neisseria meningitidis.". Biochemical Society transactions (2005): http://europepmc.org/abstract/med/15667285.
    10.1042/bst0330134
  46. Moir, James. "Purification and characterization of cytochrome c' from Neisseria meningitidis.". Biochemical Society transactions (2005): http://europepmc.org/abstract/med/15667302.
    10.1042/bst0330187
  47. Moir, James. "Respiratory detoxification of nitric oxide by the cytochrome c nitrite reductase of Escherichia coli.". The Journal of biological chemistry (2002): http://europepmc.org/abstract/med/11960983.
    10.1074/jbc.m200731200
  48. Moir, James. "Nitric oxide metabolism in Neisseria meningitidis.". Journal of bacteriology (2002): http://europepmc.org/abstract/med/12003939.
    10.1128/jb.184.11.2987-2993.2002
  49. Moir, James. "Two domains of a dual-function NarK protein are required for nitrate uptake, the first step of denitrification in Paracoccus pantotrophus.". Molecular microbiology (2002): http://europepmc.org/abstract/med/11967076.
    10.1046/j.1365-2958.2002.02859.x
  50. Moir, James. "Maximal expression of membrane-bound nitrate reductase in Paracoccus is induced by nitrate via a third FNR-like regulator named NarR.". Journal of bacteriology (2001): http://europepmc.org/abstract/med/11371524.
    10.1128/jb.183.12.3606-3613.2001
  51. Moir, James. "Enzymatic removal of nitric oxide catalyzed by cytochrome c' in Rhodobacter capsulatus.". Journal of bacteriology (2001): http://europepmc.org/abstract/med/11325932.
    10.1128/jb.183.10.3050-3054.2001
  52. Moir, James. "Nitrate and nitrite transport in bacteria.". Cellular and molecular life sciences : CMLS (2001): http://europepmc.org/abstract/med/11289303.
    10.1007/pl00000849
  53. Moir, James. "Cytochrome c' from Rhodobacter capsulatus confers increased resistance to nitric oxide.". Journal of bacteriology (2000): http://europepmc.org/abstract/med/10671472.
    10.1128/jb.182.5.1442-1447.2000
  54. Moir, James. "Nitric oxide in bacteria: synthesis and consumption.". Biochimica et biophysica acta (1999): http://europepmc.org/abstract/med/10320675.
    10.1016/s0005-2728(99)00032-8
  55. Moir, James. "Cytochrome c' from Paracoccus denitrificans: spectroscopic studies consistent with a role for the protein in nitric oxide metabolism.". Biochimica et biophysica acta (1999): http://europepmc.org/abstract/med/10082934.
    10.1016/s0167-4838(98)00276-3
  56. Moir, James. "Optical biosensing of nitric oxide using the metalloprotein cytochrome c'.". The Analyst (1999): http://europepmc.org/abstract/med/10563051.
    10.1039/a806921b
  57. Moir, James. "The diversity of redox proteins involved in bacterial heterotrophic nitrification and aerobic denitrification.". Biochemical Society transactions (1998): http://europepmc.org/abstract/med/9765887.
    10.1042/bst0260401
  58. Moir, James. "Heterotrophic nitrification in Paracoccus denitrificans.". Biochemical Society transactions (1998): http://europepmc.org/abstract/med/9765927.
    10.1042/bst026s208
  59. Moir, James. "Two enzymes with a common function but different heme ligands in the forms as isolated. Optical and magnetic properties of the heme groups in the oxidized forms of nitrite reductase, cytochrome cd1, from Pseudomonas stutzeri and Thiosphaera pantotropha.". Biochemistry (1997): http://europepmc.org/abstract/med/9405061.
    10.1021/bi971677a
  60. Moir, James. "Heterologous expression of heterotrophic nitrification genes.". Microbiology (Reading, England) (1997): http://europepmc.org/abstract/med/9421902.
    10.1099/00221287-143-12-3775
  61. Moir, James. "The biochemical characterization of a novel non-haem-iron hydroxylamine oxidase from Paracoccus denitrificans GB17.". The Biochemical journal (1996): http://europepmc.org/abstract/med/8920986.
    10.1042/bj3190823
  62. Moir, James. "The purification of ammonia monooxygenase from Paracoccus denitrificans.". FEBS letters (1996): http://europepmc.org/abstract/med/8654570.
    10.1016/0014-5793(96)00463-2
  63. Moir, James. "Enzymes and associated electron transport systems that catalyse the respiratory reduction of nitrogen oxides and oxyanions.". Biochimica et biophysica acta (1995): http://europepmc.org/abstract/med/8534676.
    10.1016/0005-2728(95)00092-5
  64. Moir, James. "Pseudospecific docking surfaces on electron transfer proteins as illustrated by pseudoazurin, cytochrome c550 and cytochrome cd1 nitrite reductase.". Nature structural biology (1995): http://europepmc.org/abstract/med/7583671.
    10.1038/nsb1195-975
  65. Moir, James. "The anatomy of a bifunctional enzyme: structural basis for reduction of oxygen to water and synthesis of nitric oxide by cytochrome cd1.". Cell (1995): http://europepmc.org/abstract/med/7736589.
    10.1016/0092-8674(95)90390-9
  66. Moir, James. "Spontaneous mutation of Thiosphaera pantotropha enabling growth on methanol correlates with synthesis of a 26 kDa c-type cytochrome.". FEMS microbiology letters (1993): http://europepmc.org/abstract/med/8270198.
    10.1016/0378-1097(93)90225-q
  67. Moir, James. "Crystallization and preliminary crystallographic study of cytochrome cd1 nitrite reductase from Thiosphaera pantotropha.". Journal of molecular biology (1993): http://europepmc.org/abstract/med/8396650.
    10.1006/jmbi.1993.1473
  68. Moir, James. "The purification of a cd1-type nitrite reductase from, and the absence of a copper-type nitrite reductase from, the aerobic denitrifier Thiosphaera pantotropha; the role of pseudoazurin as an electron donor.". European journal of biochemistry (1993): http://europepmc.org/abstract/med/8383046.
    10.1111/j.1432-1033.1993.tb17672.x

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