PAULA ISABEL DA SILVA MOREIRA (9C16-2F47-6D91)

Curriculum Vitae

PAULA ISABEL DA SILVA MOREIRA

Paula I. Moreira received her PhD in Biomedical Sciences from University of Coimbra, Portugal, in 2007. Currently, she is Associate Professor at the Faculty of Medicine and Group Leader at the Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal. Moreira's group is interested in 1) elucidating the role of energy metabolism, with an emphasis on mitochondria (energy, homeostasis and signals) and insulin/IGF-1-mediated signaling pathways in brain changes occurring in metabolic disorders (e.g. diabetes and obesity) and neurodegenerative diseases, particularly Alzheimer disease; 2) clarifying the role of hypoxia and sex/gender in the neurodegenerative events that characterize these pathologies; and 3) exploring the preventive and therapeutic potential of pharmacological (e.g. mitochondrial modulators) and non-pharmacological (e.g. hypoxic (pre)conditioning) strategies. Several experimental models are used such as isolated mitochondria, in vitro and in vivo/ex vivo models of disease and human samples. Moreira has published more than 250 scientific peer-reviewed scientific articles and book chapters. She is also a co-editor of the book "Alzheimer's Disease: New Beginnings" (ISBN print 978-1-61499-875-4; ISBN online 978-1-61499-876-1). She is Co-Editor-in-Chief of Journal of Alzheimer's Disease, Associate Editor of Journal of Alzheimer's Disease Reports and Frontiers of Aging Neuroscience, Section Editor of BBA-Molecular Basis of Disease and belongs to the editorial board of Antioxidants Redox Signaling and Aging Brain, among others. Moreira won several distinctions including the Stimulus to Research prize, in 2003, supported by the Calouste Gulbenkian Foundation, the L'Oréal for Women in Science Award, in 2008, supported by L'Oréal Portugal/UNESCO/FCT, and, in 2023, the RFS Award in Science for Antioxidants & Redox Signaling journal, supported by Mary Ann Liebert, Inc., in collaboration with the Rosalind Franklin Society. She has been recognized as a World Expert in Alzheimer's Disease and mitochondria by Expertscape, in addition to being named on the 2021 and 2022 editions of the prestigious World's Top 2% Scientists list compiled by Stanford University.

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Identificação

Identificação pessoal

Nome completo: PAULA ISABEL DA SILVA MOREIRA

Nomes de citação

Moreira, Paula
Paula I. Moreira
Moreira, PI
Moreira, Paula Isabel

Identificadores de autor

Ciência ID: 9C16-2F47-6D91
ORCID iD: 0000-0001-5177-6747
AuthenticusID: R-000-E6F
Google Scholar ID: https://scholar.google.pt/citations?user=5JO6pzkAAAAJ&hl=pt-PT
Researcher Id: B-3608-2009

Endereços de correio eletrónico

pismoreira@gmail.com (Profissional)
pimoreira@fmed.uc.pt (Profissional)
venta@ci.uc.pt (Profissional)

Moradas

Pólo III, Pólo das Ciências da Saúde, 3000-548, Azinhaga de Santa Comba, Celas, Coimbra, Portugal (Profissional)
Centro de Neurociências e Biologia Celular, Universidade de Coimbra, Rua Larga, Faculdade de Medicina, Pólo I, 1º andar, 3004-504, Coimbra, Coimbra, Portugal (Profissional)

Websites

https://www.cnc.uc.pt/en/people/p-moreira (Profissional)
https://www.researchgate.net/profile/Paula_Moreira3 (Profissional)

Domínios de atuação

Ciências Médicas e da Saúde - Medicina Básica - Neurociências

Idiomas

Idioma	Conversação	Leitura	Escrita	Compreensão	Peer-review
Português (Idioma materno)
Inglês	Utilizador proficiente (C1)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)

Formação

	Grau	Classificação
2007/07/16 Concluído	Ciências Biomédicas (Doutoramento) Especialização em Neurociências Universidade de Coimbra - Faculdade de Medicina, Portugal "Mitochondrial dysfunction in Alzheimer's disease and diabetes : effect of compounds with antioxidant properties" (TESE/DISSERTAÇÃO)	Aprovado com Distinção e Louvor, por unanimidade
2002/05/23 Concluído	Biologia Celular (Mestrado) Especialização em Não Aplicável Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal "Effect of Aß25-35 in the mitochondrial permeability transition pore: a comparative study " (TESE/DISSERTAÇÃO)
1998/07/09 Concluído	Biologia (Licenciatura) Especialização em Ramo Científico Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal

Percurso profissional

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2007 - Atual	Investigador (Investigação)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Docência no Ensino Superior

	Categoria Profissional Instituição de acolhimento	Empregador
2024/01 - Atual	Professor Associado (Docente Universitário)	Universidade de Coimbra - Faculdade de Medicina, Portugal

2016 - 2023/12	Professor Auxiliar (Docente Universitário)	Universidade de Coimbra - Faculdade de Medicina, Portugal
	Universidade de Coimbra - Faculdade de Medicina, Portugal
2014 - 2015	Professor Auxiliar Convidado (Docente Universitário)	University of Texas at San Antonio, Estados Unidos
	University of Texas at San Antonio College of Sciences, Estados Unidos
2011 - 2015	Professor Auxiliar Convidado (Docente Universitário)	Universidade de Coimbra - Faculdade de Medicina, Portugal
	Universidade de Coimbra - Faculdade de Medicina, Portugal
2005 - 2011	Assistente (Docente Universitário)	Universidade de Coimbra - Faculdade de Medicina, Portugal
	Universidade de Coimbra - Faculdade de Medicina, Portugal

Projetos

Bolsa

	Designação	Financiadores
2022 - Atual	Zfra 1-31: an early intervention in T2D-associated neurodegeneration EXPL/MED-FSL/0033/2021 Investigador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal) Em curso
2020/02 - Atual	Lipidomic fingerprint of MAMs in Alzheimer's disease - impact of its modulation on neuronal metabolism SFRH/BD/148801/2019 Orientador Universidade de Coimbra - Faculdade de Medicina, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal) Em curso
2023 - 2024	Exploring the therapeutic potential of mitochondrial uncouplers in the context of Alzheimer's disease ERG2023 Mentor Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal	European Society for Clinical Investigation Em curso
2022 - 2023	An exploratory study of the gender-specific response to hypoxia in Alzheimer's disease ERG2022 Mentor Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	European Society for Clinical Investigation Em curso
2022 - 2023	MitoBOOST v2.0 - Prova de Conceito para o Uso de Polifenóis Dirigidos à Mitocôndria para Tratar a Doença do Fígado Gordo Não-Alcoólico MitoBOOST v2.0 Investigador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Comissão de Coordenação e Desenvolvimento Regional do Centro Em curso
2021 - 2022	Zfra 1-31 peptide as a new candidate to fight type 2 diabetes-associated brain damage: a pilot study ERG 2021 Mentor Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	European Society for Clinical Investigation Em curso
2019/04/01 - 2022	Rational Drug Design of novel potent multifunctional agents for Alzheimer's Disease treatment SFRH/BD/138460/2018 Orientador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Universidade de Coimbra Faculdade de Farmácia, Portugal	Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal) Concluído
2016/03/01 - 2019/03/31	Exploring the crosstalk of neuronal WWOX and mitochondria in type 2 diabetes-associated neurodegeneration SFRH/BPD/107741/2015 Orientador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal) Concluído
2016/07/01 - 2019/01/31	Unveiling the potential of HIF-1a as a biomarker and therapeutic target in Alzheimer’s disease SFRH/BPD/109822/2015 Orientador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal) Concluído
2017 - 2019	Unravelling the neuroprotective role of peripheral co-administration of liraglutide and ghrelin on brain and cognitive function in Huntington disease SFRH/BPD/84473/2012 Orientador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Concluído
2015 - 2018	Does habitual physical activity mitigates chemotherapy-induced cardiac and brain dysfunction in a mouse model of prostate cancer? Role of mitochondrial-mediated mechanisms SFRH/BPD/108322/2015 Orientador Universidade do Porto Centro de Investigação em Actividade Física Saúde e Lazer, Portugal	Concluído
2015 - 2018	HDAC3 neurophysiology and drug targeting in neurodegeneration SFRH/BPD/102259/2014 Orientador Universidade do Porto Faculdade de Farmácia, Portugal	Fundação para a Ciência e a Tecnologia, I.P. Concluído
2014/05/01 - 2017	Mild mitochondrial uncoupling: exploring its protective effects against brain damage associated to insulin-induced hypoglycemic events in type 1 diabetes SFRH/BPD/95770/2013 Orientador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal	Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal) Fundação para a Ciência e a Tecnologia, I.P. Concluído
2013/03/01 - 2016/06/30	Mitochondrial trafficking in Alzheimer’s disease and hypoxic preconditioning: unveiling the role of the hypoxia up-regulated mitochondrial movement regulator SFRH/BPD/84163/2012 Orientador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal) Concluído
2013 - 2016	IMPACT OF PERIPHERAL EXENDIN-4 THERAPY ON THE MOLECULAR MECHANISMS UNDERLYING DIFFERENTIAL GENDER-RELATED BRAIN FUNCTION IN LONG-TERM TYPE 2 DIABETES SFRH/BPD/84473/2012 Orientador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal) Concluído
2009/03 - 2013/02	Diabetes-associated endothelium dysfunction: a cause of neurodegeneration? The role of brain endothelial mitochondria SFRH/BD/43965/2008 Orientador Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal) Concluído
2009/01/01 - 2012/12/31	DECIPHERING THE ROLE OF MITOCHONDRIA AND UNCOUPLING PROTEINS IN HYPOGLYCEMIA- AND/OR HYPERGLYCEMIA-INDUCED BRAIN INJURY SFRH/BD/43968/2008 Orientador Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal) Concluído
2008/03/01 - 2012/02/29	ROLE OF MITOCHONDRIA IN THE REGULATION OF THE TRANSCRIPTION FACTOR HYPOXIA-INDUCIBLE FACTOR-1 IN BRAIN ENDOTHELIUM: POTENTIAL PROTECTION AGAINST DIABETIC COMPLICATIONS SFRH/BD/40702/2007 Orientador Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Concluído
2007 - 2010	Impact of aging and gender in diabetic brain metabolism, oxidative stress and inflammation: Is there a (protective) role for insulin therapy? SFRH/BPD/26872/2006 Orientador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Concluído
2002 - 2006	Mitocôndria e sua relação com o envelhecimento, a doença de Alzheimer e a diabetes: papel da proteína b-amilóide SFRH/BD/5320/2001 Bolseiro de Doutoramento Fundação para a Ciência e a Tecnologia, Portugal	Fundação para a Ciência e a Tecnologia
2000 - 2002	Efeito do peptídeo beta-amilóide no poro de permeabilidade transitória da mitocôndria PRAXIS XXI/BM/20952/1999 Bolseiro de Mestrado Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal) Concluído

Projeto

	Designação	Financiadores
2021/01/01 - 2025/12/31	Center for Innovative Biomedicine and Biotechnology - Associate Laboratory LA/P/0058/2020 Universidade de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2018 - 2022	The ups and downs of cellular stress: the MAMs hypothesis for Bipolar disorder pathophysiology CENTRO-01-0145-FEDER-028214 Investigador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Concluído
2019/07 - 2021/07	A Saúde no Saber 45-2019/478 Investigador Ciência Viva, Portugal	Em curso
2017/01 - 2020	HealthyAging2020 HealthyAging2020 CENTRO-01-0145-FEDER-000012-N2323 Investigador	Comissão de Coordenação e Desenvolvimento Regional do Centro
2019/01/01 - 2019/12/31	CNC. IBILI UID/NEU/04539/2019 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Universidade de Coimbra, Portugal Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2016/04/01 - 2019/12/31	Tratamento do cancro e da doença de Alzheimer: à descoberta de novos fármacos SII&DT 3269 Drugs2CAD Investigador Universidade de Coimbra, Portugal	Agência Nacional de Inovação, S.A. Concluído
2018 - 2019	Brain protection by Evolocumab in individuals at high risk for cardiovascular disease: from bench to bedside PEPITA2018 Investigador responsável Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Universidade de Coimbra - Faculdade de Medicina Concluído
2016 - 2018	Targeting huntingtin proteostasis and mitochondria to prevent neuronal dysfunction in Huntington's disease PTDC/NEU-NMC/0412/2014 Investigador	Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)
2016 - 2018	The changing brain in Alzheimer's disease: is the retina a reliable mirror of disease onset and progression? Prémio Mantero Belard 2015 Investigador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Concluído
2014/03 - 2015/02	Ageing@Coimbra: A Co-location Centre in the European Knowledge and Innovation Network for Active and Healthy Ageing Provided by PTCRIS: 135805 135805 Investigador	Fundação para a Ciência e a Tecnologia, I.P. Concluído
2014 - 2015	Selenate and Reduction of Neurofibrillary Tangle Formation: Role of Selenoproteins U54MD008149 Investigador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	National Institute on Minority Health and Health Disparities Concluído
2013 - 2015	Mitochondrial Trafficking In Alzheimer Disease: Revealing the Role of HUMMR NIRG-13-282387 Investigador responsável Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Alzheimer's Association
2013 - 2015	New Strategies to Manage Brain Diseases CENTRO-07-ST24-FEDER-002002 Investigador	Programa Operacional Regional do Centro - Projecto Mais Centro Concluído
2013 - 2014	Faulty cross-talk between endothelial cells and neurons in Alzheimer´s disease brain. Does endoplasmic reticulum stress play a role? MOREIRA06JAN13 Investigador responsável	Faculty of Medicine, University of Coimbra
2010/04 - 2013/09	Can Phytoestrogens be Safe and Effective Food Additives for Women During Menopause? - An In Vitro and In Vivo Approach to the problem. 108326 Provided by PTCRIS: 108326 Investigador	Fundação para a Ciência e a Tecnologia, I.P.
2011/03 - 2013/08	Mitochondrial preconditioning: potential neuroprotective effect in Alzheimer's disease 110990 Provided by PTCRIS: 110990 Investigador responsável	Fundação para a Ciência e a Tecnologia, I.P.
2010/04/01 - 2013/07/15	Caloric restriction increases lifespan: role of neuropeptide Y on autophagy PTDC/SAU-FCF/099082/2008 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2010/04 - 2013/03	The pathological interaction between diabetes and Alzheimer's disease: exploring the role of brain endothelial mitochondria and uncoupling proteins 103325 Provided by PTCRIS: 103325 Investigador responsável	Fundação para a Ciência e a Tecnologia, I.P.
2011/01/01 - 2012/12/31	Strategic Project - LA 1 - 2011-2012 PEst-C/SAU/LA0001/2011 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2008/11/15 - 2012/03/13	Um novo mecanismo para a disfunção endotelial na diabetes: Dos fenotipos às moleculas PTDC/SAU-OSM/67498/2006 Universidade de Coimbra, Portugal Universidade de Coimbra Faculdade de Medicina, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2008/11 - 2012/03	A new route for endothelial dysfunction on diabetes: From phenotypes to molecules 67498 Provided by PTCRIS: 67498 Investigador	Fundação para a Ciência e a Tecnologia, I.P.
2011 - 2012	Influence of gender on the molecular mechanisms underlying aging-related changes in diabetic brain: the impact of insulin therapy PMADSC Investigador responsável	Faculty of Medicine, University of Coimbra
2008 - 2010	Towards novel inhibitors of Alzheimer’s disease-associated beta-amyloid aggregation and toxicity: from statins as potential leads to the design of effective drugs III-45 Investigador responsável Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal	Institute for Interdisciplinary Research, University of Coimbra Concluído
2008 - 2009	Da diabetes à demência: Explorando as vias de sinalização mediadas pela mitocôndria e suas proteínas desacopladoras ---- Investigador responsável Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Concluído
2007 - 2009	Exploring the crosstalk between mitochondrial reactive oxygen species and the transcriptional factor hypoxia factor-1 in brain and retinal endothelium ------ Investigador responsável Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	European Foundation for the Study of Diabetes Concluído

Produções

Publicações

Artigo em jornal	Resende, Rosa; Silva, Ana; Cláudia Maria Fragão Pereira (PhD); Moreira, Paula Isabel; Santos, Armanda E; Cruz, Maria Teresa; Fernandes, Tânia; et al. "Doenças neurodegenerativas: um quebra-cabeças com solução à vista", O Público, 2021 Ramalho-Santos, João; Varela Amaral, Sara; Álvaro, Ana Rita ; Rego, Ana Cristina; Carvalho, Ana Luisa; Barros-Viegas, Ana Teresa; Cavadas, Claudia; et al. "Viagens sem Insónias", Jornal "O Público", 2018, http://www.cnbc.pt/docs/andrecaetano_layout_BD_SONO_2018__pt.pdf.
Artigo em revista	Correia, Sónia C.; Perry, George; Moreira, Paula I.. "Fueling Alzheimer’s Disease: Where Does Immunometabolism Stand?". Journal of Alzheimer's Disease 100 s1 (2024): S363-S385. http://dx.doi.org/10.3233/jad-240787. 10.3233/jad-240787 Cardoso, Susana; Carvalho, Cristina; Correia, Sónia C.; Moreira, Paula I.. "Protective effects of 2,4-dinitrophenol in okadaic acid-induced cellular model of Alzheimer's disease". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1870 6 (2024): 167222. http://dx.doi.org/10.1016/j.bbadis.2024.167222. 10.1016/j.bbadis.2024.167222 Carvalho, Cristina; Moreira, Paula I.. "MitoTempo protects against ne-carboxymethyl lysine-induced mitochondrial dyshomeostasis and neuronal cells injury". Free Radical Biology and Medicine 220 (2024): 192-206. http://dx.doi.org/10.1016/j.freeradbiomed.2024.05.011. 10.1016/j.freeradbiomed.2024.05.011 Fernandes, Tânia; Melo, Tânia; Conde, Tiago; Neves, Bruna; Domingues, Pedro; Resende, Rosa; Pereira, Cláudia F.; Moreira, Paula I.; Domingues, Maria Rosário. "Mapping the lipidome in mitochondria-associated membranes (MAMs) in an in vitro model of Alzheimer's disease". Journal of Neurochemistry (2024): http://dx.doi.org/10.1111/jnc.16072. 10.1111/jnc.16072 Tiago Sousa; Paula I. Moreira; Susana Cardoso. "Current Advances in Mitochondrial Targeted Interventions in Alzheimer's Disease". Biomedicines (2023): https://doi.org/10.3390/biomedicines11092331. 10.3390/biomedicines11092331 Coimbra, Judite R.M.; Moreira, Paula I.; Santos, Armanda E.; Salvador, Jorge A.R.. "Therapeutic potential of glutaminyl cyclases: Current status and emerging trends". Drug Discovery Today (2023): 103644. http://dx.doi.org/10.1016/j.drudis.2023.103644. 10.1016/j.drudis.2023.103644 Batista, Ana; Guimarães, Pedro; Martins, João; Moreira, Paula I.; Ambrósio, António Francisco; Castelo-Branco, Miguel; Serranho, Pedro; Bernardes, Rui. "Normative mice retinal thickness: 16-month longitudinal characterization of wild-type mice and changes in a model of Alzheimer's disease". Frontiers in Aging Neuroscience 15 (2023): http://dx.doi.org/10.3389/fnagi.2023.1161847. 10.3389/fnagi.2023.1161847 Batista, Ana; Guimarães, Pedro; Serranho, Pedro; Nunes, Ana; Martins, João; Moreira, Paula I.; Ambrósio, António Francisco; et al. "Retinal imaging in animal models: Searching for biomarkers of neurodegeneration". Frontiers in Ophthalmology 3 (2023): http://dx.doi.org/10.3389/fopht.2023.1156605. 10.3389/fopht.2023.1156605 Cristina Carvalho; Paula I. Moreira. "Metabolic defects shared by Alzheimer's disease and diabetes: A focus on mitochondria". Current Opinion in Neurobiology (2023): https://doi.org/10.1016/j.conb.2023.102694. 10.1016/j.conb.2023.102694 Tânia Fernandes; M. Rosário Domingues; Paula I. Moreira; Cláudia F. Pereira. "A Perspective on the Link between Mitochondria-Associated Membranes (MAMs) and Lipid Droplets Metabolism in Neurodegenerative Diseases". Biology (2023): https://doi.org/10.3390/biology12030414. 10.3390/biology12030414 Pinho, Brígida R.; Duarte, Ana I.; Canas, Paula M.; Moreira, Paula I.; Murphy, Michael P.; Oliveira, Jorge M.A.. "Redox signalling and proteostasis in neurodegeneration: In vivo effects of the mitochondria-targeted antioxidant MitoQ in Huntington's disease mice". Free Radical Biology and Medicine 198 (2023): S5-S6. http://dx.doi.org/10.1016/j.freeradbiomed.2022.12.030. 10.1016/j.freeradbiomed.2022.12.030 Bernardes, Rui; Ghalati, Maryam; Ferreira, Hugo; Martins, João; Guimarães, Pedro; Moreira, Paula; Ambrósio, António; Castelo-Branco, Miguel; Serranho, Pedro. "Longitudinal OCT texture analysis to assess the retinal changes in the triple-transgenic mouse model of Alzheimer's disease". Acta Ophthalmologica 100 S275 (2022): http://dx.doi.org/10.1111/j.1755-3768.2022.0173. 10.1111/j.1755-3768.2022.0173 Cristina Carvalho; Sónia C. Correia; Raquel Seiça; Paula I. Moreira. "WWOX inhibition by Zfra1-31 restores mitochondrial homeostasis and viability of neuronal cells exposed to high glucose". Cellular and Molecular Life Sciences (2022): https://doi.org/10.1007/s00018-022-04508-7. 10.1007/s00018-022-04508-7 Ferreira, Hugo; Serranho, Pedro; Guimarães, Pedro; Trindade, Rita; Martins, João; Moreira, Paula I.; Ambrósio, António Francisco; Castelo-Branco, Miguel; Bernardes, Rui. "Stage-independent biomarkers for Alzheimer’s disease from the living retina: an animal study". Scientific Reports 12 1 (2022): http://dx.doi.org/10.1038/s41598-022-18113-y. 10.1038/s41598-022-18113-y Antónia Diniz; Marco G. Alves; Emanuel Candeias; Ana I. Duarte; Paula I. Moreira; Branca M. Silva; Pedro F. Oliveira; Luís Rato. "Type 2 Diabetes Induces a Pro-Oxidative Environment in Rat Epididymis by Disrupting SIRT1/PGC-1a/SIRT3 Pathway". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms23168912. 10.3390/ijms23168912 Guimarães, Pedro; Serranho, Pedro; Martins, João; Moreira, Paula I.; Ambrósio, António Francisco; Castelo-Branco, Miguel; Bernardes, Rui. "Retinal Aging in 3× Tg-AD Mice Model of Alzheimer's Disease". Frontiers in Aging Neuroscience 14 (2022): http://dx.doi.org/10.3389/fnagi.2022.832195. 10.3389/fnagi.2022.832195 Pereira, Ana Catarina; De Pascale, Jessica; Resende, Rosa; Cardoso, Susana; Ferreira, Isabel; Neves, Bruno Miguel; Carrascal, Mylène A.; et al. "ER-mitochondria communication is involved in NLRP3 inflammasome activation under stress conditions in the innate immune system". Cellular and Molecular Life Sciences 79 4 (2022): http://dx.doi.org/10.1007/s00018-022-04211-7. 10.1007/s00018-022-04211-7 Correia, Sónia C.; Alves, Marco G.; Oliveira, Pedro F.; Casadesus, Gemma; LaManna, Joseph; Perry, George; Moreira, Paula I.. "Hypoxic preconditioning averts sporadic Alzheimer’s disease-like phenotype in rats: a focus on mitochondria". Antioxidants & Redox Signaling (2022): http://dx.doi.org/10.1089/ars.2019.8007. 10.1089/ars.2019.8007 Susana Cardoso; Paula I. Moreira. "Insulin-Induced Recurrent Hypoglycemia Up-Regulates Glucose Metabolism in the Brain Cortex of Chemically Induced Diabetic Rats". International Journal of Molecular Sciences (2021): https://doi.org/10.3390/ijms222413470. 10.3390/ijms222413470 Sónia C. Correia; Paula I. Moreira. "Oxygen Sensing and Signaling in Alzheimer's Disease: A Breathtaking Story!". Cellular and Molecular Neurobiology (2021): https://doi.org/10.1007/s10571-021-01148-6. 10.1007/s10571-021-01148-6 Tânia Fernandes; Rosa Resende; Diana F. Silva; Ana P. Marques; Armanda E. Santos; Sandra M. Cardoso; M. Rosário Domingues; Paula I. Moreira; Cláudia F. Pereira. "Structural and Functional Alterations in Mitochondria-Associated Membranes (MAMs) and in Mitochondria Activate Stress Response Mechanisms in an In Vitro Model of Alzheimer's Disease". Biomedicines 9 8 (2021): 881-881. https://doi.org/10.3390/biomedicines9080881. 10.3390/biomedicines9080881 Ferreira, Hugo; Martins, João; Moreira, Paula I.; Ambrósio, António Francisco; Castelo-Branco, Miguel; Serranho, Pedro; Bernardes, Rui. "Longitudinal normative OCT retinal thickness data for wild-type mice, and characterization of changes in the 3×Tg-AD mice model of Alzheimer's disease". Aging (2021): http://dx.doi.org/10.18632/aging.202916. 10.18632/aging.202916 Carvalho, Cristina; Moreira, Paula I.. 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Science of aging knowledge environment : SAGE KE 2006 8 (2006): http://www.scopus.com/inward/record.url?eid=2-s2.0-33744531637&partnerID=MN8TOARS. 10.1126/sageke.2006.8.pe10 Moreira, P.I.; Zhu, X.; Lee, H.-G.; Honda, K.; Smith, M.A.; Perry, G.. "The (un)balance between metabolic and oxidative abnormalities and cellular compensatory responses in Alzheimer disease". Mechanisms of Ageing and Development 127 6 (2006): 501-506. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646160622&partnerID=MN8TOARS. 10.1016/j.mad.2006.01.024 Nunomura, A.; Castellani, R.J.; Zhu, X.; Moreira, P.I.; Perry, G.; Smith, M.A.. "Involvement of oxidative stress in Alzheimer disease". Journal of Neuropathology and Experimental Neurology 65 7 (2006): 631-641. http://www.scopus.com/inward/record.url?eid=2-s2.0-33747861696&partnerID=MN8TOARS. 10.1097/01.jnen.0000228136.58062.bf Franco, S.; Blasco, M.A.; Siedlak, S.L.; Harris, P.L.R.; Moreira, P.I.; Perry, G.; Smith, M.A.. "Telomeres and telomerase in Alzheimer's disease: Epiphenomena or a new focus for therapeutic strategy?". Alzheimer's and Dementia 2 3 (2006): 164-168. http://www.scopus.com/inward/record.url?eid=2-s2.0-33744931650&partnerID=MN8TOARS. 10.1016/j.jalz.2006.03.001 Moreira, P.I.; Honda, K.; Zhu, X.; Nunomura, A.; Casadesus, G.; Smith, M.A.; Perry, G.. "Brain and brawn: Parallels in oxidative strength". Neurology 66 2 SUPPL. 1 (2006): http://www.scopus.com/inward/record.url?eid=2-s2.0-33644850568&partnerID=MN8TOARS. Zhu, X.; Lee, H.-G.; Moreira, P.I.; Smith, M.A.; Perry, G.. "Presenilin mutation: A deadly first hit in Alzheimer disease - A commentary on "aging sensitizes towards ROS formation and lipid peroxidation in PS1M146L transgenic mice"". Free Radical Biology and Medicine 40 5 (2006): 737-739. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644659794&partnerID=MN8TOARS. 10.1016/j.freeradbiomed.2005.12.028 Moreira, P.I.; Custódio, J.; Moreno, A.; Oliveira, C.R.; Santos, M.S.. "Tamoxifen and estradiol interact with the flavin mononucleotide site of complex I leading to mitochondrial failure". Journal of Biological Chemistry 281 15 (2006): 10143-10152. http://www.scopus.com/inward/record.url?eid=2-s2.0-33744518169&partnerID=MN8TOARS. 10.1074/jbc.M510249200 Moreira, P.I.; Rolo, A.P.; Sena, C.; Seiça, R.; Oliveira, C.R.; Santos, M.S.. "Insulin attenuates diabetes-related mitochondrial alterations: A comparative study". Medicinal Chemistry 2 3 (2006): 299-308. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746153746&partnerID=MN8TOARS. 10.2174/157340606776930754 Moreira, P.I.; Cardoso, S.M.; Santos, M.S.; Oliveira, C.R.. "The key role of mitochondria in Alzheimer's disease". Journal of Alzheimer's Disease 9 2 (2006): 101-110. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746066329&partnerID=MN8TOARS. Moreira, P.I.; Zhu, X.; Nunomura, A.; Smith, M.A.; Perry, G.. "Therapeutic options in Alzheimer's disease". Expert Review of Neurotherapeutics 6 6 (2006): 897-910. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745486884&partnerID=MN8TOARS. 10.1586/14737175.6.6.897 Zhu, X.; Perry, G.; Moreira, P.I.; Aliev, G.; Cash, A.D.; Hirai, K.; Smith, M.A.. "Mitochondrial abnormalities and oxidative imbalance in Alzheimer disease". Journal of Alzheimer's Disease 9 2 (2006): 147-153. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746089859&partnerID=MN8TOARS. Moreira, P.I.; Oliveira, C.. "Foreword: Mitochondria in Alzheimer disease". Journal of Alzheimer's Disease 9 2 (2006): http://www.scopus.com/inward/record.url?eid=2-s2.0-33746065622&partnerID=MN8TOARS. Moreira, P.I.; Zhu, X.; Liu, Q.; Honda, K.; Siedlak, S.L.; Harris, P.L.; Smith, M.A.; Perry, G.. "Compensatory responses induced by oxidative stress in Alzheimer disease". Biological Research 39 1 (2006): 7-13. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745840777&partnerID=MN8TOARS. Honda, K.; Moreira, P.I.; Liu, Q.; Siedlak, S.L.; Zhu, X.; Smith, M.A.; Perry, G.. "Redox active iron at the center of oxidative stress in Alzheimer disease". Letters in Drug Design and Discovery 2 6 (2005): 479-482. http://www.scopus.com/inward/record.url?eid=2-s2.0-24744432930&partnerID=MN8TOARS. 10.2174/1570180054771545 Moreira, P.I.; Honda, K.; Liu, Q.; Santos, M.S.; Oliveira, C.R.; Aliev, G.; Nunomura, A.; et al. "Oxidative stress: The old enemy in Alzheimer's disease pathophysiology". Current Alzheimer Research 2 4 (2005): 403-408. http://www.scopus.com/inward/record.url?eid=2-s2.0-24644443839&partnerID=MN8TOARS. 10.2174/156720505774330537 Moreira, P.I.; Santos, M.S.; Sena, C.; Nunes, E.; Seiça, R.; Oliveira, C.R.. "CoQ10 therapy attenuates amyloid ß-peptide toxicity in brain mitochondria isolated from aged diabetic rats". Experimental Neurology 196 1 (2005): 112-119. http://www.scopus.com/inward/record.url?eid=2-s2.0-26244447857&partnerID=MN8TOARS. 10.1016/j.expneurol.2005.07.012 Sayre, L.M.; Moreira, P.I.; Smith, M.A.; Perry, G.. "Metal ions and oxidative protein modification in neurological disease". Annali dell'Istituto Superiore di Sanita 41 2 (2005): 143-164. http://www.scopus.com/inward/record.url?eid=2-s2.0-31644435822&partnerID=MN8TOARS. Pereira, C.; Agostinho, P.; Moreira, P.I.; Cardoso, S.M.; Oliveira, C.R.. "Alzheimer's disease-associated neurotoxic mechanisms and neuroprotective strategies". Current Drug Targets: CNS and Neurological Disorders 4 4 (2005): 383-403. http://www.scopus.com/inward/record.url?eid=2-s2.0-23144463734&partnerID=MN8TOARS. 10.2174/1568007054546117 Moreira, P.I.; Smith, M.A.; Zhu, X.; Nunomura, A.; Castellani, R.J.; Perry, G.. "Oxidative stress and neurodegeneration". Annals of the New York Academy of Sciences 1043 (2005): 545-552. http://www.scopus.com/inward/record.url?eid=2-s2.0-23744439419&partnerID=MN8TOARS. 10.1196/annals.1333.062 Petersen, R.B.; Siedlak, S.L.; Lee, H.-G.; Kim, Y.-S.; Nunomura, A.; Tagliavini, F.; Ghetti, B.; et al. "Redox metals and oxidative abnormalities in human prion diseases". Acta Neuropathologica 110 3 (2005): 232-238. http://www.scopus.com/inward/record.url?eid=2-s2.0-26444549058&partnerID=MN8TOARS. 10.1007/s00401-005-1034-4 Zhu, X.; Moreira, P.I.; Smith, M.A.; Perry, G.. "Alzheimer's disease: An intracellular movement disorder?". Trends in Molecular Medicine 11 9 (2005): 391-393. http://www.scopus.com/inward/record.url?eid=2-s2.0-24344483065&partnerID=MN8TOARS. 10.1016/j.molmed.2005.07.002 Marlatt, M.W.; Webber, K.M.; Moreira, P.I.; Lee, H.-G.; Casadesus, G.; Honda, K.; Zhu, X.; Perry, G.; Smith, M.A.. "Therapeutic opportunities in Alzheimer Disease: One for all or all for one?". Current Medicinal Chemistry 12 10 (2005): 1137-1147. http://www.scopus.com/inward/record.url?eid=2-s2.0-18544380930&partnerID=MN8TOARS. 10.2174/0929867053764644 Moreira, P.I.; Siedlak, S.L.; Aliev, G.; Zhu, X.; Cash, A.D.; Smith, M.A.; Perry, G.. "Oxidative stress mechanisms and potential therapeutics in Alzheimer disease". Journal of Neural Transmission 112 7 (2005): 921-932. http://www.scopus.com/inward/record.url?eid=2-s2.0-20944449836&partnerID=MN8TOARS. 10.1007/s00702-004-0242-8 Honda, K.; Smithi, M.A.; Zhu, X.; Baus, D.; Merrick, W.C.; Tartakoff, A.M.; Hattier, T.; et al. "Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron". Journal of Biological Chemistry 280 22 (2005): 20978-20986. http://www.scopus.com/inward/record.url?eid=2-s2.0-20444383489&partnerID=MN8TOARS. 10.1074/jbc.M500526200 Cardoso, S.M.; Moreira, P.I.; Agostinho, P.; Pereira, C.; Oliveira, C.R.. "Neurodegenerative pathways in Parkinson's disease: Therapeutic strategies". Current Drug Targets: CNS and Neurological Disorders 4 4 (2005): 405-419. http://www.scopus.com/inward/record.url?eid=2-s2.0-23144431757&partnerID=MN8TOARS. 10.2174/1568007054546072 Lee, H.-G.; Perry, G.; Moreira, P.I.; Garrett, M.R.; Liu, Q.; Zhu, X.; Takeda, A.; Nunomura, A.; Smith, M.A.. "Tau phosphorylation in Alzheimer's disease: Pathogen or protector?". Trends in Molecular Medicine 11 4 (2005): 164-169. http://www.scopus.com/inward/record.url?eid=2-s2.0-17044435830&partnerID=MN8TOARS. 10.1016/j.molmed.2005.02.008 Moreira, P.I.; Santos, M.S.; Sena, C.; Seiça, R.; Oliveira, C.R.. "Insulin protects against amyloid ß-peptide toxicity in brain mitochondria of diabetic rats". Neurobiology of Disease 18 3 (2005): 628-637. http://www.scopus.com/inward/record.url?eid=2-s2.0-14744294296&partnerID=MN8TOARS. 10.1016/j.nbd.2004.10.017 Moreira, P.I.; Oliveira, C.R.; Santos, M.S.; Nunomura, A.; Honda, K.; Zhu, X.; Smith, M.A.; Perry, G.. "A second look into the oxidant mechanisms in Alzheimer's disease". Current Neurovascular Research 2 2 (2005): 179-184. http://www.scopus.com/inward/record.url?eid=2-s2.0-18744402471&partnerID=MN8TOARS. 10.2174/1567202053586758 Smith, M.A.; Nunomura, A.; Lee, H.-G.; Zhu, X.; Moreira, P.I.; Avila, J.; Perry, G.. "Chronological primacy of oxidative stress in Alzheimer disease". Neurobiology of Aging 26 5 (2005): 579-580. http://www.scopus.com/inward/record.url?eid=2-s2.0-13644249113&partnerID=MN8TOARS. 10.1016/j.neurobiolaging.2004.09.021 Webber, K.M.; Smith, M.A.; Lee, H.-G.; Harris, P.L.; Moreira, P.; Perry, G.; Zhu, X.. "Mitogen- and stress-activated protein kinase 1: Convergence of the ERK and p38 pathways in Alzheimer's disease". Journal of Neuroscience Research 79 4 (2005): 554-560. http://www.scopus.com/inward/record.url?eid=2-s2.0-14144250344&partnerID=MN8TOARS. 10.1002/jnr.20380 Moreira, P.I.; Custódio, J.B.; Oliveira, C.R.; Santos, M.S.. "Brain mitochondrial injury induced by oxidative stress-related events is prevented by tamoxifen". Neuropharmacology 48 3 (2005): 435-447. http://www.scopus.com/inward/record.url?eid=2-s2.0-13844275276&partnerID=MN8TOARS. 10.1016/j.neuropharm.2004.10.012 Moreira, P.I.; Honda, K.; Liu, Q.; Aliev, G.; Oliveira, C.R.; Santos, M.S.; Zhu, X.; Smith, M.A.; Perry, G.. "Alzheimer's disease and oxidative stress: The old problem remains unsolved". Current Medicinal Chemistry - Central Nervous System Agents 5 1 (2005): 51-62. http://www.scopus.com/inward/record.url?eid=2-s2.0-15344351142&partnerID=MN8TOARS. Liu, Q.; Smith, M.A.; Avilá, J.; DeBernardis, J.; Kansal, M.; Takeda, A.; Zhu, X.; et al. "Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations". Free Radical Biology and Medicine 38 6 (2005): 746-754. http://www.scopus.com/inward/record.url?eid=2-s2.0-13844267510&partnerID=MN8TOARS. 10.1016/j.freeradbiomed.2004.11.005 Moreira, P.I.; Smith, M.A.; Zhu, X.; Honda, K.; Lee, H.-G.; Aliev, G.; Perry, G.. "Oxidative damage and Alzheimer's disease: Are antioxidant therapies useful?". Drug News and Perspectives 18 1 (2005): 13-19. http://www.scopus.com/inward/record.url?eid=2-s2.0-17444377148&partnerID=MN8TOARS. 10.1358/dnp.2005.18.1.877165 Lee, H.-G.; Moreira, P.I.; Zhu, X.; Smith, M.A.; Perry, G.. "Staying connected: Synapses in alzheimer disease". American Journal of Pathology 165 5 (2004): 1461-1464. http://www.scopus.com/inward/record.url?eid=2-s2.0-7244252913&partnerID=MN8TOARS. Moreira, P.I.; Smith, M.A.; Zhu, X.; Santos, M.S.; Oliveira, C.R.; Perry, G.. "Therapeutic potential of oxidant mechanisms in Alzheimer's disease". Expert Review of Neurotherapeutics 4 6 (2004): 995-1004. http://www.scopus.com/inward/record.url?eid=2-s2.0-8344235899&partnerID=MN8TOARS. 10.1586/14737175.4.6.995 Liu, Q.; Xie, F.; Siedlak, S.L.; Nunomura, A.; Honda, K.; Moreira, P.I.; Zhua, X.; Smith, M.A.; Perry, G.. "Neurofilament proteins in neurodegenerative diseases". Cellular and Molecular Life Sciences 61 24 (2004): 3057-3075. http://www.scopus.com/inward/record.url?eid=2-s2.0-12144265815&partnerID=MN8TOARS. 10.1007/s00018-004-4268-8 Moreira, P.I.; Santos, M.S.; Moreno, A.M.; Proença, T.; Seiça, R.; de Oliveira, C.R.. "Effect of streptozotocin-induced diabetes on rat brain mitochondria". Journal of Neuroendocrinology 16 1 (2004): 32-38. http://www.scopus.com/inward/record.url?eid=2-s2.0-0742324515&partnerID=MN8TOARS. 10.1111/j.1365-2826.2004.01107.x Moreira, P.I.; Custódio, J.B.; Oliveira, C.R.; Santos, M.S.. "Hydroxytamoxifen protects against oxidative stress in brain mitochondria". Biochemical Pharmacology 68 1 (2004): 195-204. http://www.scopus.com/inward/record.url?eid=2-s2.0-2942568021&partnerID=MN8TOARS. 10.1016/j.bcp.2004.03.019 Moreira, P.I.; Santos, M.S.; Moreno, A.M.; Seiça, R.; Oliveira, C.R.. "Increased vulnerability of brain mitochondria in diabetic (goto-kakizaki) rats with aging and amyloid-ß exposure". Diabetes 52 6 (2003): 1449-1456. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038321341&partnerID=MN8TOARS. 10.2337/diabetes.52.6.1449 Pereira, C.; Agostinho, P.; Moreira, P.I.; Duarte, A.I.; Santos, M.S.; Oliveira, C.R.. "Neuroprotection strategies: Effect of vinpocetinein in vitro oxidative stress models \| Estratégias de neuroprotecção: Efeito da vimpocetina em modelos in vitro de stresse oxidativo". Acta Medica Portuguesa 16 6 (2003): 401-406. http://www.scopus.com/inward/record.url?eid=2-s2.0-9644310235&partnerID=MN8TOARS. Moreira, P.I.; Santos, M.S.; Moreno, A.; Rego, A.C.; Oliveira, C.. "Effect of amyloid ß-peptide on permeability transition pore: A comparative study". Journal of Neuroscience Research 69 2 (2002): 257-267. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037100213&partnerID=MN8TOARS. 10.1002/jnr.10282 Moreira, P.I.; Santos, M.S.; Moreno, A.; Oliveira, C.. "Amyloid ß-peptide promotes permeability transition pore in brain mitochondria". Bioscience Reports 21 6 (2001): 789-800. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035780141&partnerID=MN8TOARS. 10.1023/A:1015536808304 Santos, M.S.; Duarte, A.I.; Moreira, P.I.; Oliveira, C.R.. "Synaptosomal response to oxidative stress: Effect of vinpocetine". Free Radical Research 32 1 (2000): 57-66. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033988559&partnerID=MN8TOARS. Moreira, P.; Pereira, C.; Santos, M.S.; Oliveira, C.. "Effect of zinc ions on the cytotoxicity induced by the amyloid ß- peptide". Antioxidants and Redox Signaling 2 2 (2000): 317-325. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033949740&partnerID=MN8TOARS. Pereira, C.; Moreira, P.; Seiça, R.; Santos, M.S.; Oliveira, C.R.. "Susceptibility to ß-amyloid-induced toxicity is decreased in Goto- Kakizaki diabetic rats: Involvement of oxidative stress". Experimental Neurology 161 1 (2000): 383-391. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034051172&partnerID=MN8TOARS. 10.1006/exnr.1999.7270 Moreira, Paula; Pereira, Claudia; Santos, Maria S.; Oliveira, Catarina. "Effect of Zinc Ions on the Cytotoxicity Induced by the Amyloid beta-Peptide". Antioxidants & Redox Signaling 2 2 (2000): 317-325. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000207500700014&KeyUID=WOS:000207500700014. 10.1089/ars.2000.2.2-317
Capítulo de livro	Cardoso, Susana; Moreira, Paula I.. "Neuro-glia communication and glycolysis". In Glycolysis, 27-50. Elsevier, 2024. 10.1016/b978-0-323-91704-9.00006-9 Carvalho, Cristina; Pires, Joana F.; Moreira, Paula I.; Raimundo, Nuno. "Disrupted cellular quality control mechanisms in aging". In Aging, 359-384. Elsevier, 2023. 10.1016/b978-0-12-823761-8.00016-1 Cardoso, Susana; Moreira, Paula I.. Autor correspondente: Moreira, Paula I.. "Targeting Mitochondria and Redox Dyshomeostasis in Brain Ageing: An Update". In Redox Signaling and Biomarkers in Ageing, 147-183. Springer International Publishing, 2022. Publicado • 10.1007/978-3-030-84965-8_8 Moreira, PI; Sónia C. Correia. "Unraveling the Role of Mitochondria in Alzheimer's Disease". In Vascular Disease, Alzheimer's Disease, and Mild Cognitive Impairment: Advancing an Integrated Approach, 407. Oxford, Estados Unidos: Oxford University Press, USA, 2020. Publicado Cardoso, Susana; Moreira, Paula I.. "Antidiabetic drugs for Alzheimer's and Parkinson's diseases: Repurposing insulin, metformin, and thiazolidinediones". In Metabolic and Bioenergetic Drivers of Neurodegenerative Disease: Treating neurodegenerative diseases as metabolic diseases, 37-64. Elsevier, 2020. Publicado • 10.1016/bs.irn.2020.02.010 Carvalho, Cristina; Moreira, Paula I.. "Cognitive Impairment in Obesity and Diabetes". In Obesity and Diabetes, 399-414. Springer International Publishing, 2020. 10.1007/978-3-030-53370-0_29 Correia, S.C.; Moreira, P.I.. "Role of mitochondria in neurodegenerative diseases: The dark side of the "Energy factory"". 2018. Cardoso, S.M.; Correia, S.C.; Carvalho, C.; Moreira, P.I.. "Mitochondria in Alzheimer’s disease and diabetes-associated neurodegeneration: License to heal!". 2017. 10.1007/164_2017_3 Cardoso, S.; Seiça, R.; Moreira, P.I.. "Diabesity and brain energy metabolism: The case of alzheimer’s disease". 2017. 10.1007/978-3-319-63260-5_5 Castellani, R.J.; Correia, S.C.; Moreira, P.I.; Perry, G.. "Tackling Alzheimer's Disease by Targeting Oxidative Stress and Mitochondria". 2016. 10.1016/B978-0-12-802173-6.00018-6 Correia, S.C.; Moreira, P.I.; Perry, G.. "Autophagy in alzheimer’s disease: A cleaning service out-of-order?". 2015. 10.1007/978-3-319-13939-5_7 Marques-Aleixo, I.; Santos-Alves, E.; Moreira, P.I.; Oliveira, P.J.; Magalhães, J.; Ascensão, A.. "Exercise-Induced Protection Against Aging and Neurodegenerative Diseases: Role of Redox- and Mitochondrial-Based Alterations". 2015. 10.1002/9781118840634.ch26 Nunes, A.R.; Alves, M.G.; Moreira, P.I.; Oliveira, P.F.; Silva, B.M.. "Impact of green tea (Camellia Sinensis L.) consumption in diabetes mellitus-induced neurodegeneration". 2015. Castellani, R.J.; Moreira, P.I.; Zhu, X.; Perry, G.. "Alzheimer's Disease: Pathology and Pathogenesis". 2014. 10.1016/B978-0-12-801238-3.00160-4 Santos, R.X.; Moreira, P.I.. "Mtor is a potential therapeutic target for alzheimer's disease". 2014. Santos, Renato; Correia, Sónia; Cardoso, Susana; Carvalho, Cristina; Candeias, Emanuel; Plácido, Ana; Duarte, ANA; Santos, Maria; Moreira, Paula. "Role of Mitochondria and Oxidative Stress in Parkinson¿s Disease". In Role of Oxidative Stress in Chronic Diseases, 521-548. United States: CRC Press, 2014. Publicado • 10.1201/b16653-26 Carvalho, C.; Santos, R.X.; Cardoso, S.; Correia, S.C.; Moreira, P.I.. "Chronic hypoxia, type 2 diabetes and Alzheimer's disease: A dangerous triad". 2013. Duarte, A.; Candeias, E.; Correia, S.C.; Santos, R.X.; Carvalho, C.; Cardoso, S.; Plácido, A.I.; et al. "The Janus Face of Insulin in Brain". 2013. 10.1002/9781118395318.ch5 Cardoso, S.; Carvalho, C.; Correia, S.; Santos, R.X.; Santos, M.S.; Moreira, P.I.. "Mitochondrial uncoupling proteins - therapeutic targets in neurodegeneration?". 2011. Carvalho, C.; Correia, S.C.; Santos, R.X.; Cardoso, S.; Santos, M.S.; Moreira, P.I.. "Diabetes, mitochondria and brain endothelium dysfunction: A dangerous triad for neurodegeneration?". 2011. Nunomura, A.; Takeda, A.; Moreira, P.I.; Castellani, R.J.; Lee, H.-G.; Zhu, X.; Smith, M.A.; Perry, G.. "Neurofibrillary tangle formation as a protective response to oxidative stress in Alzheimer's disease". 2009. 10.1007/978-0-387-87995-6_9 Moreira, P.I.; Smith, M.A.; Zhu, X.; Nunomura, A.; Perry, G.. "The potential application of antioxidant agents in Alzheimer disease therapeutics". In Ageing research reviews. 2007. 10.1007/978-0-387-71522-3_12
Edição de número de revista	Moreira, PI; George Perry; Jesus Avila; Aaron Serensen; Massimo Tabaton. "Preface: Alzheimer's Disease: New Beginnings". Journal of Alzheimer s Disease 64 1 (2018): https://content.iospress.com/journals/journal-of-alzheimers-disease/64/s1. Publicado • 10.1111/nyas.1982.396.issue-1 Moreira, P.I.. "Mini-Symposium: Energy Demand and Energy Supply in Alzheimer’s Disease - Introduction". Brain Pathology 26 5 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84988637950&partnerID=MN8TOARS. 10.1111/bpa.12398
Livro	Several. Alzheimer's Disease: New Beginnings. Países Baixos: IOS Press BV. 2018. Publicado • Editor
Poster em conferência	Carvalho, Cristina; Paula I. Moreira. "Neuroprotective effects of Zfra 1-31 peptide against high glucose-induced mitochondrial and autophagy defects". Trabalho apresentado em 57th Annual Meeting of the European Association for the Study of Diabetes, 2021. Coimbra, Judite RM; Moreira, Paula Isabel; Santos, Armanda E; SALVADOR, J.A.R.. "Novel Glutaminyl Cyclase Inhibitors Discovered by Molecular Modeling Studies". Trabalho apresentado em 8th EFMC Young Medicinal Chemists¿ Symposium (EFMC-YMCS 2021), 2021. Coimbra, Judite RM; Moreira, Paula Isabel; Santos, Armanda E; Jorge A. R. Salvador, Salvador, J.. "A Virtual Screening Protocol to Identify Novel Inhibitors of Glutaminyl Cyclase". Trabalho apresentado em XXVI EFMC International Symposium on Medicinal Chemistry (EFMCISMC 2021, 2021. Coimbra, Judite R. M.; Baptista, Salete J.; Santos, Armanda E.; Moreira, Paula Isabel; Silva, Maria M.C; Dinis, Teresa C. P.; Jorge A. R. Salvador. "APPLICATION OF COMPUTATIONAL METHODS FOR DISCOVERY OF NOVEL BACE1 INHIBITORS: LIGAND- AND STRUCTURE-BASED PROTOCOLS WITH IN VITRO EVALUATION". Trabalho apresentado em 13th National Organic Chemistry Meeting & 6th National Medicinal Chemistry Meeting, January 15 - 17, 2020, Aveiro, Portugal, 2020. Coimbra, Judite RM; Baptista, Salete J.; Silva, MMC; Dinis, Teresa; Moreira, Paula Isabel; Santos, Armanda E; SALVADOR, J.A.R.. "Application of Computational Methods for Discovery of Novel BACE1 Hit Inhibitors: Ligand- and Structure-based Protocols with In Vitro Evaluation". Trabalho apresentado em the 13th National Organic Chemistry Meeting & 6th National Medicinal Chemistry Meeting, 2020. Mena, Débora; Alves, Inês N.; Sjögren M; Silva, Daniela; Oliveira CR; Moreira, PI; Björkqvist M; Duarte AI. "Dual therapy with liraglutide and ghrelin improves brain mitochondrial energy metabolism in the R6/2 mouse model for Huntington¿s disease". Trabalho apresentado em 1st Meeting of CIBB ¿ Center for Innovative Biomedicine & Biotechnology, 2020. Rodrigues-Neves AC; Carecho, Rafael; Filipa Baptista; Paula I. Moreira; António Francisco Ambrósio. "Do the retina and brain share similar glial patterns in an animal model of Alzheimer's disease?". Trabalho apresentado em XIV European Meeting on Glial Cells in Health and Disease, 2019. Moreira, PI. "Retinal thinning of inner layers is associated with visual cortex atrophy in a mouse model of Alzheimer's disease: a longitudinal in vivo multimodal study". Trabalho apresentado em ARVO Annual Meeting, 2019. Coimbra, Judite R. M.; Baptista, Salete J.; Santos, Armanda E; Moreira, Paula Isabel; Silva, Maria M.C; Dinis, Teresa C.P; Salvador, Jorge A. R.. "TARGETING ALZHEIMER¿S DISEASE: A VIRTUAL SCREENING PROTOCOL TO DISCOVER NEW CENTRAL-ACTING BACE1 INHIBITORS". Trabalho apresentado em Spring 2019 ACS National Meeting & Expo, Chemistry for New Frontiers, March 31 - April 4, 2019, Orlando, FL, USA, 2019. Coimbra, Judite R. M.; Baptista, Salete J.; Santos, Armanda E.; Moreira, Paula Isabel; Silva, Maria M. C.; Dinis, Teresa C.P; Salvador, Jorge A. R.. "TARGETING ALZHEIMER¿S DISEASE: AN INTEGRATED PROTOCOL OF VIRTUAL SCREENING FOR DISCOVERY OF NOVEL ANTI-BACE1 AGENTS". Trabalho apresentado em 14th International Conference on Alzheimer's and Parkinson's Diseases and related neurological disorders, March 26-31, 2019, Lisbon, Portugal, 2019. Sousa, Fábio J.; Carrascal, Mylene; Moreira, Paula Isabel; Santos, Armanda E; Cruz, Maria Teresa; Pereira, Cláudia. "Impact of ER stress on neuronal mitochondria". Trabalho apresentado em 1st Annual Meeting in Pharmaceutical Sciences, 2019. Rodrigues-Neves AC; Rafael Carecho; Elisa Campos; Paula I. Moreira; Filipa I. Baptista; António F. Ambrósio. "Is the retina a reliable mirror of Alzheimer¿s disease brain? screening of molecular and cellular parameters.". Trabalho apresentado em in ISER meeting, Belfast, Northern Ireland, UK., 2018. Rodrigues-Neves; Carecho, Rafael; Filipa Baptista; Paula I. Moreira; António Francisco Ambrósio. "Is the retina a reliable mirror of Alzheimer¿s disease brain? Screening of molecular and celular parameter". Trabalho apresentado em XXIII Biennial Meeting of the International Society for Eye Research (ISER), 2018. Pinho, Tiffany; Correia, SC; Moreira, PI. "The bittersweet side of O-GlcNacylation in Alzheimer's disease-related mitochondrial abnormalities.". Trabalho apresentado em MitoPorto - Mitochondrial Evolution, Metabolism and Disease, 2018. Pinho, Tiffany; Correia, SC; Moreira, PI. "The bittersweet relation between O-GlcNAcylation and Alzheimer's disease: a focus on mitochondria.". Trabalho apresentado em 52nd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI) ¿ ¿Precision medicine for healthy aging¿, 2018. Diniz, A; Candeias, E; Duarte, AI; Moreira, PI; Silva, BM; Alves, MG; Rato, L.. "Type 2 diabetes mellitus disrupts the molecular axis SIRT1/PGC-1a/SIRT3 predisposing to oxidative environment in the rat epididymis". Trabalho apresentado em XIII ANNUAL CICS SYMPOSIUM, 2018. Alves, Marco G.; Rato, L.; Diniz, A; Candeias, E; Duarte, AI; Moreira, PI; Silva, BM; Alves, MG; Oliveira, PF. "Type 2 diabetes Mellitus compromises the epididymal SIRT1/PGC1-alpha/SIRT3 axis predisposing to oxidative environment". Trabalho apresentado em I NoTeS Congress, 2018. Rodrigues-Neves AC; Chiquita, S; Carecho, R; Baptista, FI; Moreira, PI; Ambrósio, AF. "Can the retina mirror the alterations observed in Alzheimer¿s disease brain at early stages?". Trabalho apresentado em Portuguese Glial Network, 2018. Pinho, Tiffany; Correia, SC; Moreira, PI. "O-GlcNAcylation represents a "sweet" route to tackle abnormal mitochondrial function and neuronal loss in Alzheimer's disease.". Trabalho apresentado em MitoPorto - Advances in mitochondrial research, 2017. Rodrigues-Neves AC; Samuel Chiquita; Rafael Carecho; Filipa I. Baptista; Paula I. Moreira; António F. Ambrósio. "The retina as a mirror of the alterations observed in Alzheimer¿s disease brain? Evaluation of structural, cellular and molecular changes.". Trabalho apresentado em XV SPN, Braga, Portugal., 2017. Rodrigues-Neves AC; Samuel Chiquita; Carecho, Rafael; Filipa Baptista; Paula I. Moreira; António Francisco Ambrósio. "The retina as a mirror of the alterations observed in Alzheimer¿s disease brain? Evaluation of structural, cellular and molecular change". Trabalho apresentado em XV Annual Meeting of the Portuguese Society for Neuroscience (SPN), 2017. Carecho, Rafael; Rodrigues-Neves AC; Filipa Baptista; Paula I. Moreira; António Francisco Ambrósio. "Are the main features of Alzheimer¿s brain mirrored by the retina?". Trabalho apresentado em XV Annual Meeting of the Portuguese Society for Neuroscience (SPN), 2017. Correia, SC; Moreira, PI. "Type 2 diabetic female rat brains are less vulnerable to oxidative stress and Alzheimer disease-related hallmarks: a role for insulin/igf-1/estrogen signaling?". Trabalho apresentado em XII CNC Annual Meeting, 2015. Correia SC; Pinho TS; Zhu X; Perry, George; Moreira, PI. "Loss of HUMMR participates on mitochondrial traffic jams.". Trabalho apresentado em XIV Meeting of the Portuguese Society for Neuroscience, 2015. Rato, L.; Alves, MG; Santos, MS; Moreira, PI; Cavaco, JE; Duarte, AI; Oliveira, PF. "Impact of Reduced Testosterone Levels Induced by Progressive Stages of Diabetes Mellitus on Sertoli cells Glycolytic and Bioenergetic Profiles". Trabalho apresentado em I congress in health sciences. Towards innovation and entrepeneurship: trends in endocrinology and neurosciences, 2015. Correia, SC; Moreira, PI. "Stimulation of mitochondrial biogenesis and mitochondrial elongation during preconditioning: the brain adapting to survive!". Trabalho apresentado em 38th FEBS Congress, 2013. Correia, SC; Moreira, PI. "Effects of type 1 diabetes and insulin therapy on brain mitochondrial dynamics and autophagy.". Trabalho apresentado em XIII Meeting of the Portuguese Society for Neuroscience, 2013. Correia, SC; Moreira, PI. "Mitoplasticity during hypoxic preconditioning: the brain battles to survive!". Trabalho apresentado em XIII Meeting of the Portuguese Society for Neuroscience, 2013. Correia, SC; Moreira, PI. "Tolerância cerebral mediada pelo pré-condicionamento por hipóxia num modelo animal de insulino-resistência central". Trabalho apresentado em Annual meeting of the Portuguese Society of Diabetology, 2013. Rato, L.; Duarte, AI; Alves, Marco G.; Santos, MS; Moreira, PI; Cavaco, PE; Socorro, S.; Oliveira, PF. "Testicular mitochondrial bioenergetics is altered in pre-diabetes induced by a high-energy diet in rats". Trabalho apresentado em FEBS Congress, 2013. Ferreiro, Elisabete; Ana Isabel Plácido; Catarina Resende de Oliveira; Moreira, Paula Isabel; Cláudia Maria Fragão Pereira. "Role of endoplasmic reticulum in the endothelial-neuronal dialogue in Alzheimer´s disease". Trabalho apresentado em 8th Forum of European Neuroscience, Barcelona, Spain, 2012. Neuhaus-Oliveira, A.; Alves, Marco G.; Moreira, PI; Socorro, S; Oliveira, PF. "Exposure to 2,4-Dichlorophenoxyacetic Acid induces important metabolic alterations in Sertoli cells that may compromise the spermatogenesis". Trabalho apresentado em VII CICS Symposium, 2012. Ana Isabel Plácido; Ferreiro, Elisabete; Catarina Resende de Oliveira; Cláudia Maria Fragão Pereira; Moreira, Paula Isabel. "Endoplasmic reticulum stress induces brain endothelial cells dysfunction and death independently of caspase-12 pathway". Trabalho apresentado em 1st PF2MUC Symposium, Coimbra, Portugal, 2011. Susana Cardoso; Renato X. Santos; Cristina Carvalho; Sónia Correia; Sandrina Silva; Gonçalo C. Pereira; Susana P. Pereira; et al. "Brain mitochondria as a potential target of doxorubicin action". Trabalho apresentado em IV International Courses on Toxicology 2008 ¿ ¿Metabolic Toxicology: From the Pathway to Organism¿, 2008.
Resumo em conferência	Tânia Patrícia Dias Fernandes; Moreira, PI; et al.. Autor correspondente: Moreira, PI. "Impaired ER-mitochondria contacts affect lipid droplets metabolism in an in vitro Alzheimer's disease model.". Trabalho apresentado em 8th International Conference on Mitochondria in Aging, Cancer and Cell Death, Coimbra, 2024. Publicado Susana Maria Tomé Tieres Cardoso; Sónia Catarina de Sousa Correia; Moreira, PI; Carvalho, Cristina Isabel Marques Maurício de. "WWOX: a promoter of brain mitochondrial dysfunction in a mouse model of type 2 diabetes". Trabalho apresentado em 8th International Conference on Mitochondria in Aging, Cancer and Cell Death, Coimbra, 2024. Publicado C Carvalho, SC Correia, S Cardoso, PI Moreira. Untangling the protective role of Zfra 1-31 peptide against type 2 diabet. "Untangling the protective role of Zfra 1-31 peptide against type 2 diabetes-associated brain damage: preliminary results of a pilot study". Trabalho apresentado em 56th Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI), Bari, 2022. Publicado Moreira, PI; Carvalho, Cristina. "Neuroprotective effects of Zfra 1-31 peptide against high glucose-induced mitochondrial and autophagy defects". Trabalho apresentado em 57th Annual Meeting of the European Association for the Study of Diabetes 2021 - EASD2021, 2021. Publicado Cardoso, Susana; Diano, Sabrina; Moreira, PI. "UCP2 inhibition modulates cognition and brain mitochondrial function under different metabolic insults.". Trabalho apresentado em 55th Annual Scientific Meeting of the European Society for Clinical Investigation - ESCI2021, 2021. Publicado T Fernandes; R Resende; MR Domingues; Moreira, PI; C Pereira. "Physical and biochemical alterations in endoplasmic reticulum-mitochondria contacts in an Alzheimer's disease in vitro model". Trabalho apresentado em 55th Annual Scientific Meeting of the European Society for Clinical Investigation - ESCI2021, 2021. Publicado D Mena; IN Alves; DF Silva; E Candeias; CR Oliveira,; R Seiça; PF Monteiro; Moreira, PI; AI Duarte. "The Neuroprotection by GLP-1 Receptor Agonists in High Cardiovascular risk and Neurodegenerative Diseases". Trabalho apresentado em 55th Annual Scientific Meeting of the European Society for Clinical Investigation - ESCI2021, 2021. Publicado S Correia; M Alves; P Oliveira; G Casadesus; G Perry; Moreira, PI. "Hypoxia preconditioning-triggered mitochondrial remodeling in a rat model of sporadic Alzheimer's disease: A" breath of fresh air" towards effective treatment?". Trabalho apresentado em 55th Annual Scientific Meeting of the European Society for Clinical Investigation - ESCI2021, 2021. Publicado Moreira, PI; C Carvalho. "WWOX inhibition in neuronal cells exposed to high glucose ameliorates mitochondrial dynamics and autophagy preventing cell death". Trabalho apresentado em 55th Annual Scientific Meeting of the European Society for Clinical Investigation - ESCI2021, 2021. Publicado C Carvalho; C Martin; Moreira, PI. "N epsilon-Carboxymethyl lysine induces mitochondrial-associated defects in differentiated SH-SY5Y neuroblastoma cells". Trabalho apresentado em 55th Annual Scientific Meeting of the European Society for Clinical Investigation - ESCI2021, 2021. Publicado D Franco da Silva; MI Alves; D Mena; D Vaz; PF Monteiro; Moreira, PI; AI Duarte. "The neuroprotective effects of peripheral treatment with Evolocumab in middle-aged rat at high cardiovascular risk". Trabalho apresentado em European Society for Clinical Investigation (ESCI) 2020: Utrecht, NL, Utrecht, 2020. Publicado D Mena; MI Alves; DF Silva; D Vaz; E Candeias; CR Oliveira; PF Monteiro; Moreira, PI; AI Duarte. "Diet-induced high cardiovascular risk compromises brain hippocampal metabolism and long-term spatial memory in middle-aged male rats". Trabalho apresentado em 53rd Annual Meeting of the European Society for Clinical Investigation, Utrecht, 2020. Publicado D Mena; MI Alves; M Sjogren; DF Silva; CR Oliveira; Moreira, PI; M Bjorkqvist; AI Duarte. "Co-administration of liraglutide and ghrelin ameliorates brain mitochondrial energy metabolism in the R6/2 mouse model for Huntington's disease". Trabalho apresentado em 53rd Annual Meeting of the European Society for Clinical Investigation, Utrecht, 2020. Publicado MI Alves; D Mena; DF Silva; R Seica; CR Oliveira; AI Duarte; Moreira, PI. "Type 2 diabetes mitigates brain cortical energy metabolism in middle-aged female rats". Trabalho apresentado em 53rd Annual Meeting of the European Society for Clinical Investigation, Utrecht, 2020. Publicado Agostinho Almeida; Marina C. Pinto; Paula Marinho Reis; Edgar Pinto; Paula I. Moreira; Sandra Freitas; Mário R. Simões. "Trace Elements Levels in Hair and Cognitive Status in an Elderly Environmentally Exposed Population: A Case Study in the Surroundings of an Industrial Area.". Trabalho apresentado em the 13th Biennial ISTERH2019 Conference, Bali, 2019. Publicado Ambrósio, A.F.; Chiquita, Samuel; Castelhano, Joao; Ribeiro, Mário; Sereno, José; Carecho, Rafael; Rodrigues-Neves AC; et al. "Is the retina a reliable window to look into the brain in Alzheirmer's disease? Lessons from an animal model". Trabalho apresentado em XXIII Biennial Meeting of the International Society for Eye Research, Belfast, 2018. Publicado António Francisco Ambrósio; Rodrigues-Neves AC; Samuel Chiquita; Carecho, Rafael; Filipa Baptista; Elisa Campos; Paula I. Moreira. "Structural, functional and molecular alterations in the retina of a mouse model of Alzheimer¿s disease". Trabalho apresentado em Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Honolulu, Hawaii, 2018. Publicado Rodrigues-Neves AC; Samuel Chiquita; Carecho, Rafael; Elisa Campos; Paula I. Moreira; Filipa Baptista; António Francisco Ambrósio. "Alzheimer¿s disease: can the retina be a window to the brain?". Trabalho apresentado em XX European Association for Vision and Eye Research (EVER), Nice, 2017. Publicado António Francisco Ambrósio; Samuel Chiquita; Rodrigues-Neves AC; Carecho, Rafael; Filipa Baptista; Elisa Campos; Paula I. Moreira. "Can the retina be used as a reliable mirror to evaluate changes occurring in the Alzheimer¿s brain?". Trabalho apresentado em Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Baltimore, 2017. Publicado Cavaco, JE; Rato, L.; Alves, Marco G.; Duarte, AI; Santos, MS; Moreira, PI; Olivera, PF. "How does Sertoli cell metabolism responds to the reduced testosterone levels induced by progressive stages of Diabetes Mellitus?". Trabalho apresentado em Medicine, 2016. 10.1097/MD.0000000000002371 Silva, BM; Alves, Marco G.; Nunes, AR; Dias, TR; Moreira, PI; Oliveira, PF. "White tea (Camellia sinensis) consumption improves heart and brain glycolytic and oxidative profiles in prediabetic rats". Trabalho apresentado em Planta Medica, 2015. 10.1055/s-0035-1565707 Rato, L.; Alves, Marco G.; Duarte, AI; Santos, MS; Moreira, PI; Cavaco, JE; Oliveira, PF. "Progressive stages of diabetes mellitus induce testosterone deficiency promoting a modulation of Sertoli cell metabolism". Trabalho apresentado em Human Reproduction, 2015. 10.1093/humrep/30.Supplement_1.1 Rato, L.; Duarte, AI; Tomás, GD; Santos, MS; Moreira, PI; Socorro, S; Cavaco, JE; Alves, Marco G.; Oliveira, PF. "Pre-diabetes disrupts testicular PGC1-a/SIRT3 axis prompting to oxidative stress". Trabalho apresentado em Biochimica et Biophysica Acta, 2015. 10.1016/j.bbabio.2014.05.24 Marques, Ricardo; Vaz, Cátia; Alves, M.G.; Moreira, PI; Oliveira PF; Cavaco, J.E.; Maia CJ; Socorro, Sílvia. "Androgens regulate gene expression of glucose transporters and glycolytic enzymes in prostate cancer cells". Trabalho apresentado em 16th European Congress of Endocrinology, Wroclaw, 2014. 10.1530/endoabs.35.P571 Cavaco, JE; Rato, L.; Alves, Marco G.; Dias, TR; Lopes, G.; Socorro, S.; Oliveira, PF; et al. "Fast Food may Induce Pre-Diabetes Impairing Testicular Function in Rats". Trabalho apresentado em VIII Annual CICS Symposium, 2013. 10.1111/febs.12396 Resende, Rosa; Moreira, Paula Isabel; Deshpande, Atul; Busciglio, Jorge; Pereira, Cláudia Fragão; Oliveira, Catarina R. "Increased oxidative stress is an early pathological feature in 3xTg-AD mice.". Trabalho apresentado em Alzheimer's Association International Conference on Alzheimer's Disease (ICAD), Chicago, 2008. Publicado • 10.1016/j.jalz.2008.05.2250
Tese / Dissertação	Moreira, Paula; Santos, Maria; Carvalho, Cristina Isabel Marques Maurício de. "The interplay between vascular and mitochondrial abnormalities in type 2 diabetes and Alzheimer's disease". Doutoramento, 2013. http://hdl.handle.net/10316/23526. Moreira, PI. "Mitochondrial dysfunction in Alzheimer's disease and diabetes : effect of compounds with antioxidant properties". Doutoramento, Universidade de Coimbra Faculdade de Medicina, 2007. http://hdl.handle.net/10316/7501. Moreira, PI. "Effect of the amyloid beta peptide on the permeability transition pore: a comparative study". Mestrado, Universidade de Coimbra - Faculdade de Ciências e Tecnologia, 2002.

Atividades

Apresentação oral de trabalho

	Título da apresentação	Nome do evento Anfitrião (Local do evento)
2023/03/17	O inibidor da WWOX Zfra1-31 melhora a função cognitiva e a disfunção das mitocôndrias de cérebros de ratinhos com diabetes tipo 2	19th Meeting of Portuguese Society for Diabetes Sociedade Portuguesa de Diabetologia (Vilamoura, Portugal)
2023/01/25	WWOX: a new therapeutic target in Type 2 diabetes-associated neurodegeneration	DCV - Talks Universidade de Coimbra, Faculdade de Ciências e Tecnologia (Coimbra, Portugal)
2022/11/12	WWOX inhibition by Zfra1-31 ameliorates brain mitochondrial dysfunction and oxidative stress in a mouse model of type 2 diabetes	2nd International Meeting of the Portuguese Society of Physiology Sociedade Portuguesa de Fisiologia (Coimbra, Portugal)
2022/07/18	Metabolic Defects in Alzheimer's Disease	International Research Conference on Neurodegenerative Diseases Global Association for the Study of Neurodegenerative Diseases (Omaha, Estados Unidos)
2022/06/08	Untangling the protective role of Zfra 1-31 peptide against type 2 diabetes-associated brain damage: preliminary results of a pilot study	56th Annual Scientific Meeting European Society for Clinical Investigation European Society for Clinical Investigation (Bari, Itália)
2022/05/25	Diabetes and Alzheimer's disease crosstalk	Nova Medical School Seminars Faculdade de Ciências Médicas, Universidade Nova de Lisboa (Lisboa, Portugal)
2022/04/22	Impaired insulin and IGF-1 signaling affects brain mitochondria and redox homeostasis	Spanish Symposium on IGFs and Insulin 2022: Implications in Physiology and Disease (Logroño, Espanha)
2022/03/10	A inibição da proteína WWOX protege a mitocôndria e previne a morte de neurónios expostos a níveis elevados de glicose	18th Meeting of Portuguese Society for Diabetes Sociedade Portuguesa de Diabetologia (Vilamoura, Portugal)
2021/11/18	Structural and functional alterations in mitochondria-associated membranes (MAMs) in an in vitro model of Alzheimer's disease	2º Retiro do Grupo de Metabolismo, Envelhecimento e Doença (MAD) do Centro de Inovação em Biomedicina e Biotecnologia (CIBB) (Coimbra, Portugal)
2021/09/11	N-Carboxymethyl lysine induces mitochondrial-associated defects in differentiated SH-SY5Y neuroblastoma cells	55th Annual Scientific Meeting - ESCI Virtual 2021 European Society for Clinical Investigation
2021/07/27	Neuroprotective effect of Zfra 1-31 peptide against high glucose-induced mitochondrial dynamics and autophagy alterations	57th EASD Annual Meeting European Society for the study of diabetes 2021 European Association for the Study of Diabetes
2021/07/19	Zfra 1-31 prevents high glucose-induced neuronal death through improvement of mitochondrial and autophagy defects	International Conference on Diabetes and Endocrinology. Coalesce Research Group (Online)
2021/07/02	Alzheimer disease beyond amyloid: a preclinical perspective	35ª REUNIÃO ANUAL DO GEECD - Inovação em Doença de Alzheimer GEECD - Grupo de Estudos em Envelhecimento Cerebral e Demência (Coimbra, Portugal)
2021/06/10	Hypoxia preconditioning-triggered mitochondrial remodeling in a rat model of sporadic Alzheimer's disease: a "breath of fresh air"	55th Annual Scientific Meeting of the European Society for Clinical Investigation European Society for Clinical Investigation (Online)
2021/06/09	Physical and biochemical alterations in endoplasmic reticulum-mitochondria contacts in an Alzheimer's disease in vitro model	55ª Reunião científica anual da Sociedade Europeia para a Investigação Clínica (ESCI) European Society for Clinical Investigation (Webinar)
2021/06/06	UCP2 inhibition modulates cognition and brain mitochondrial function under different metabolic insults	55th Annual Scientific Meeting of the European Society for Clinical Investigation - ESCI2021 European Society for Clinical Investigation (On line)
2021/06/06	WWOX inhibition in neuronal cells exposed to high glucose ameliorates mitochondrial dynamics and autophagy preventing cell death	55th Annual Scientific Meeting - ESCI Virtual 2021 European Society for Clinical Investigation
2021/06/03	Loss of HUMMR as a potential 'roadblock' for mitochondrial movement in Alzheimer's disease	35th Meeting of the Portuguese Group of Studies on Aging and Dementia GEECD GEECD - Grupo de Estudos em Envelhecimento Cerebral e Demência (Webinar)
2021/04/26	Mitochondrial dysfunction and oxidative stress in Alzheimer's disease	Redox Webinar Series - Crosstalk between oxidative stress and metabolic defects: implications for Alzheimer's disease Faculty of Pharmacy and Medicine, Sapienza University of Rome (Rome, Itália)
2020/09/26	Hypoxic precoditioning averts sporadic Alzheimer's disease-like phenotype in rats: the role of mitochondrial remodeling	34th Meeting of the Portuguese Group of Studies on Aging and Dementia GEECD GEECD - Grupo de Estudos em Envelhecimento Cerebral e Demência (Portugal)
2020/09/26	Structural and functional alterations in endoplasmic reticulum-mitochondria contacts in Alzheimer's disease in vitro models	34ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência (GEECD) GEECD - Grupo de Estudos em Envelhecimento Cerebral e Demência (Webinar, Portugal)
2020/02/06	Changes in the Protein Composition of Mitochondrial-Associated Membranes (MAMs) in Alzheimer's Disease	50ª Reunião da Sociedade Portuguesa de Farmacologia Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2019/05	Hypoxic preconditioning: a strategy to fight Alzheimer’s disease?	European Society of Clinical Investigation (Coimbra, Portugal)
2018/03	Mitochondrial dysfunction and energy failure in Alzheimer’s disease	Focused Symposium “Bioenergetics and neurodegenerative disorders: moving from pathogenesis to therapeutics”; Advances in Neuroscience for Medical Advance Centre for Therapeutic Innovation in Neuropsychiatry, Institut de Recherches Servier (França)
2016/06/04	Alzheimer's disease: mechanistic insights and biomarkers discovery	30ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência (Lisboa, Portugal)
2016	Alzheimer's disease: focus on mitochondria	Seminars_IBILI (Coimbra, Portugal)
2015/10	The efficacy of the antidiabetic drug liraglutide in Alzheimer’s disease-like pathology	6th Annual Alliance for Healthy Ageing: Interventions to Slow Down Aging (Newcastle, Reino Unido)
2015/03	Insulin signaling as a bridge between diabetes and Alzheimer’s disease	Gordon Research Conference - IGF & Insulin System in Physiology & Disease (California, Estados Unidos)
2014/07	Mitochondria take center stage in Alzheimer’s disease	18th European BioEnergetics Conference – EBEC 2104 (Lisboa, Portugal)
2014/04	Etiologia e fisiopatologia das doenças neurodegenerativas	Ciclo de Palestras em Atividade Física e Saúde “Exercício, Saúde e Sociedade CIAFEL - Universidade do Porto (Porto, Portugal)
2014	A diabetes tipo 2 e a doença de Alzheimer	Jornadas de Análises Clínicas e Saúde Pública – Reunião Anual 2014 Escola Superior de Tecnologia da Saúde de Coimbra (Coimbra, Portugal)
2013	Mitochondrial crossroad in Alzheimer’s disease	47th Annual Scientific Meeting of the European Society for Clinical Investigation (Albufeira, Portugal)
2011	Mitochondria and the Vasculature	7th International Congress on Vascular Dementia (Riga, Letónia)
2010/11/22	Alzheimer’s disease: research tools and therapeutic perspectives	Palestras do Núcleo de Estudantes de Bioquímica Núcleo de Estudantes de Bioquímica (Coimbra, Portugal)
2010/05/03	Mitochondria, diabetes and Alzheimer’s disease	Seminars on neuropharmacology and functional imaging II: integrating mitochondria, diabetes and neurodegeneration Universidade do Porto (Porto, Portugal)
2009/07	A disfunção mitocondrial na doença de Alzheimer	II Jornadas de Bioquímica da UTAD Universidade de Trás-os-Montes e Alto Douro (Vila Real, Portugal)
2008/07	A mitocôndria, um catalizador do envelhecimento cerebral e da demência	Ciência 2008 – Encontro com a Ciência em Portugal Promovido pelos Laboratórios Associados Fundação Calouste Gulbenkian (Lisboa, Portugal)
2007/11/08	Diabetes is a risk factor for Alzheimer disease: the role of mitochondria	5th International Congress on Vascular Dementia (Budapeste, Hungria)
2007/11	O papel da mitocôndria na doença de Alzheimer	1º Congresso Científico de Saúde: Doenças Neurodegenerativas Faculdade de Farmácia da Universidade de Lisboa (Lisboa, Portugal)
2007/04/28	Liver mitochondria isolated from ovariectomized and tamoxifen-treated ovariectomized rat females are affected by estradiol	1st Iberic Meeting on Medicinal Chemistry: Anticancer Agents – 1IMMC (Régua, Portugal)
2006/12/08	Tamoxifen and estradiol: a deadly combination for cancer cells	XV National Congress of Biochemistry Sociedade Portuguesa de Bioquímica (Aveiro, Portugal)
2006/07	Mitochondrial autophagocytosis in Alzheimer disease	10th International Conference on Alzheimer´s Disease and Related Disorders (Madrid, Espanha)
2006/03	Tamoxifen and estradiol lead to mitochondrial complex I failure	International Courses on Toxicology “Smart Toxicology: Subcellular Targets of Anti-Cancer Therapy” Universidade de Coimbra, Centro de Neurociencias e Biologia Celular
2006	Oxidative Stress in Alzheimer disease: role of antioxidants	4th International Congress on the Improvement of the Quality of Life in Dementia, Epilepsy, MS and Peripheral Neuropathies (Odessa, Ucrânia)
2005/10	Brain mitochondria as a link between Alzheimer’s disease and diabetes	4th International Congress on Vascular Dementia (Porto, Portugal)
2005/07/03	Brain mitochondrial dysfunction is a common feature in both diabetes and Alzheimer’s disease	19ª Reunião do grupo de estudos do envelhecimento cerebral e demência (Tomar, Portugal)
2005/04	Effect of amyloid beta-peptide on brain mitochondria isolated from diabetic rats	Mitochondria: Between Life and Death – International Courses on Toxicology (Coimbra, Portugal)
2003/12/15	Diabetes and Alzheimer’s Disease: Are Brain Mitochondria a Link Between Both Pathologies?	1º Workshop de Bioquímica Clínica (Porto, Portugal)
2003/12	Role of Insulin in Brain Mitochondria Status of Type 1 Diabetic Rats. Does Amyloid beta-Peptide Interferes with Mitochondrial Function?	16st Luso-Spanish Congress on Free Radicals / 6th Portuguese Congress on Free Radicals in Chemistry, Biology and Medicine
2002/07/14	Bioenergética mitocondrial e o envelhecimento	16ª Reunião-Grupo de Estudos – Envelhecimento Cerebral e Demência
2001	Mitochondria: a target for beta-amyloid peptide	XXXII Reunião Anual da Sociedade Portuguesa de Farmacologia e XX Reunião de Farmacologia Clínica (Coimbra, Portugal)
2000/07/02	Mitocôndria e o envelhecimento: efeito do peptídeo Abeta25-35	14ª Reunião - Grupo de Estudos: Envelhecimento Cerebral e Demência

Orientação

	Título / Tema Papel desempenhado	Curso (Tipo) Instituição / Organização
2023 - Atual	WWOX e complicações cardíacas na diabetes tipo 2 Coorientador	Mestrado Integrado em Medicina (Mestrado) Universidade de Coimbra - Faculdade de Medicina, Portugal
2020 - 2024	Lipidomic fingerprint of MAMs in Alzheimer's disease - impact of its modulation on neuronal metabolism Orientador	Ciências Biomédicas (Doutoramento) Universidade de Coimbra - Faculdade de Medicina, Portugal
2019 - 2023	Rational drug design of novel potent multifunctional agents for Alzheimer´s disease treatment Coorientador	Ciências Farmacêuticas (Doutoramento) Universidade de Coimbra Faculdade de Farmácia, Portugal
2013 - 2022	Exendin-4 therapy in Alzheimer´s disease and diabetic brain: effect in mitochondria and insulin-mediated pathways Coorientador	Biologia Experimental e Biomedicina (Doutoramento) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2016 - 2017	O-GlcNAcylation represents a "sweet" route to tackle Alzheimer's disease-related phenotype Orientador	Biologia Celular e Molecular (Mestrado) Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal
2016 - 2017	Neuronal energy status and Alzheimer’s disease: searching for a connection Orientador	Bioquímica (Mestrado) Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal
2015 - 2016	Protective effects of hypoxic preconditioning against sporadic Alzheimer’s disease-like pathology - focus on insulin signaling, mitochondrial dynamics and autophagy Orientador	Mestrado Integrado em Medicina (Mestrado) Universidade de Coimbra - Faculdade de Medicina, Portugal
2014 - 2015	Effects of vitamin D deficient and high-fat diets in the diabetic brain: focus on insulin signaling Orientador	Bioquímica (Mestrado) Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal
2011 - 2015	Role of endoplasmic reticulum stress in the cross-talk between neurons and brain endothelial cells - Implications for Alzheimer's disease Orientador	Ciências Biomédicas (Doutoramento) Universidade de Coimbra - Faculdade de Medicina, Portugal
2013 - 2014	Brain endothelial cells protection by pinacidil preconditioning in an okadaic acid-induced Alzheimer’s disease model: role of mitoKATP channels, ROS and HIF-1a Orientador	Biologia Celular e Molecular (Mestrado) Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal
2013 - 2014	Effect of the Daily Consumption of White Tea in the Cerebral Cortex of Prediabetic Rats Coorientador	Ciências Biomédicas (Mestrado) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2011 - 2013	Efeitos do metilglioxal e da piridoxamina na bioenergética e no estado redox de mitocôndrias de cérebro de rato Orientador	Mestrado Integrado em Medicina (Mestrado) Universidade de Coimbra - Faculdade de Medicina, Portugal
2010 - 2013	Deciphering the role of mitochondria and uncoupling proteins in hypoglycemia- and/or hyperglycemia-induced brain injury Orientador	Biologia Celular (Doutoramento) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2010 - 2013	Diabetes-associated endothelium dysfunction: a cause of neurodegeneration? The role of brain endothelial mitochondria Orientador	Biologia (Doutoramento) Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal
2010 - 2013	Impact of diabetes and insulin in the selective degradation of brain mitochondria by mitophagy Orientador	Biologia (Doutoramento) Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal
2009 - 2012	Role of mitochondria in the regulation of factor hypoxia-inducible factor-1 in brain endothelium under diabetic conditions Orientador	Biologia (Doutoramento) Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal
2010 - 2011	Effect of age and chronic hypoxia on oxidative status, mitochondria and apoptosis in rat liver Orientador	Bioquímica (Mestrado) Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal
2009 - 2010	Effects of Aß1-40 and 17ß-estradiol on brain mitochondrial oxidative stress and damage Orientador	Biologia Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal
2007 - 2008	Efeito da metformina na bioenergética mitocondrial e no stresse oxidativo Orientador	Biologia Celular (Mestrado) Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal

Organização de evento

	Nome do evento Tipo de evento (Tipo de participação)	Instituição / Organização
2024/04/22 - 2024/05/03	ONE HEALTH: A Metabolic Approach from the Cell to Society Advanced Course - PHD Programme in Experimental Biology and Biomedicine (2024 - 2024) Outro	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2023/04/03 - 2023/04/13	ONE HEALTH: A Metabolic Approach from the Cell to Society Advanced Course - PHD Programme in Experimental Biology and Biomedicine (2023) Outro (Coorganizador)	Universidade de Coimbra - Centro de Neurociências e Biologia Celular, Portugal
2022/04/04 - 2022/04/08	Advanced Course "Metabolic and inflammatory drivers in age-related neurodegenerative diseases" (2022/04/04) Outro (Coorganizador)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/05/23 - 2019/05/24	Symposium - Neurobiology of Aging; 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (2019 - 2019) Simpósio	European Society for Clinical Investigation, Países Baixos
2019/04/08 - 2019/04/12	Advanced Course - Neurodegenerative Disorders PhD Programme in Experimental Biology and Biomedicine (2019 - 2019) Outro (Coorganizador)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013/02/25 - 2013/03/01	Advanced Course - Neurobiology and Disease Doctoral Programme in Health Sciences (2013 - 2013) Outro (Coorganizador)	Universidade de Coimbra - Faculdade de Medicina, Portugal
2012/12/10 - 2012/12/14	Advanced Course - Biology of Proteolysis in Pathology; PhD Programme in Experimental Biology and Biomedicine (2012 - 2012) Outro (Coorganizador)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Participação em evento

	Descrição da atividade Tipo de evento	Nome do evento Instituição / Organização
2022/07/18 - 2022/07/18	Session chair - International Research Conference on Neurodegenerative Diseases Conferência	International Research Conference on Neurodegenerative Diseases

Júri de grau académico

	Tema Tipo de participação	Nome do candidato (Tipo de grau) Instituição / Organização
2024/01/31	SC-Nanophytosomes to address neurodegenerative diseases challenge: a novel concept of mitochondria-targeted therapy. Arguente principal	Daniela Sofia Gonçalves Mendes (Doutoramento) Universidade do Porto Faculdade de Farmácia, Portugal
2023/10	Hippocampal lipid droplets and the gut microbiome: effects of type 2 diabetes and exercise	Gezime Seferi (Doutoramento) Oslo universitetssykehus, Noruega
2021	Role of TOMM40'523 - APOE haplotypes in Alzheimer's disease etiology - from clinics to mitochondria Arguente	Remy Cardoso (Doutoramento) Universidade NOVA de Lisboa NOVA Medical School, Portugal
2020	Brain energy and neurotransmitter metabolism in the 5xFAD mouse model of Alzheimer's disease Arguente principal	Jens Velde Andersen (Doutoramento) IT-Universitet i København, Dinamarca
2019	Targeting Hsp70 in Huntington's disease Arguente principal	Sara Daniela de Sousa Reis (Doutoramento) Universidade do Porto Faculdade de Farmácia, Portugal
2019	Physical exercise as a preventive and therapeutic strategy against behavioral dysfunction in Alzheimer’s disease Arguente principal	Telma Bernardo (Doutoramento) Universidade do Porto Faculdade de Desporto, Portugal
2019	Decoding the interplay between TAZ and metabolism in early lung development Arguente principal	Henrique Silva (Mestrado) Universidade do Minho Escola de Medicina, Portugal
2018	Deregulated inflammasome in Bipolar Disorder (BD): a matter of stress? Arguente principal	Ana Catarina de Jesus Pais Pereira (Mestrado) Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal
2018	The role of beclin 1 deacetylation on autophagic flux in Alzheimer´s disease Arguente principal	Filipa Isabel Parreiras Filipe (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2017	Evaluation of neuroprotective and neurotoxic functions of diferente microglia phenotypes in Alzheimer’s disease onset and progression, using in vitro and in vivo models Arguente	Cláudia Alexandra Oliveira Lopes Caldeira (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2017	Biological effects of new BACE1 inhibitors for Alzheimer´s disease treatment Arguente principal	Verónica Resende Figueiredo (Mestrado) Universidade de Coimbra Faculdade de Farmácia, Portugal
2017	Autophagy in Neurodegeneration: Latest developments on eating ourselves out of disease Arguente principal	Pedro Xavier Pinto Figueiredo (Mestrado) Universidade de Coimbra - Faculdade de Medicina, Portugal
2016	Novas abordagens terapêuticas para os fármacos baseados nas incretinas Arguente principal	Ana Luísa Vieira da Natividade Faria João (Mestrado) Universidade de Coimbra - Faculdade de Medicina, Portugal
2015	Modulation of neuronal mitochondrial dynamics, autophagy and huntingtin proteostasis by HDAC inhibitors: Insights for Huntington's disease Arguente principal	Pedro Gonçalo Guedes Dias (Doutoramento) Universidade do Porto Faculdade de Farmácia, Portugal
2015	Sirtuin 2 in hypothalamus: an emerging target in insulin resistance? Arguente principal	Liliana Isabel Fernandes dos Santos (Mestrado) Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal
2014	Chronic exercise mitigates doxorubicin-induced cardiac and brain mitochondrial liabilities. Effects on mitochondrial activity, oxidative stress, apoptotic signaling, mitochondrial dynamics and quality control Arguente principal	Inês Sofia Marques Aleixo (Doutoramento) Universidade do Porto Faculdade de Desporto, Portugal
2014	Insulin signalling depends on the endocannabinoid system in the brain Arguente principal	Carla Sofia da Silva Santos (Mestrado) Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal
2013	Transthyretin as a signaling molecule: influence on IGF-IR pathway and 14-3-3-¿ metabolism Arguente principal	Marta Virgínia Mota Vieira (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2013	Impact of H9c2 Cardiomyoblasts Differentiation on Isoproterenol Toxicity: Different Modulation of Signaling Pathways Arguente	Ana Filipa Roque Branco (Doutoramento) Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal
2013	Bioenergética do músculo esquelético na doença de Alzheimer Arguente principal	Marisa Alexandra Torres de Castro (Mestrado) Universidade de Trás-os-Montes e Alto Douro, Portugal
2013	Autophagy in cortical neurons: role of caloric restriction and neuropeptide Y Arguente principal	Marisa Ferreira Marques (Mestrado) Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal
2013	Evaluation of a dipeptidyl peptidase IV inhibitor as a microvascular protector in diabetes Arguente principal	Maria Luísa Morais de Almeida (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013	The multifaceted role of the endocannabinoid system in the regulation of cerebral glucose uptake Arguente principal	Ana Bárbara da Silva Pinheiro (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013	Papel do exercício físico na disfunção endotelial Presidente do júri	Papel do exercício físico na disfunção endotelial (Mestrado) Universidade de Coimbra - Faculdade de Medicina, Portugal
2013	Efeito da berberina na sensibilidade à insulina num modelo animal de diabetes tipo 2 Presidente do júri	Daniel Tavares Rego (Mestrado) Universidade de Coimbra - Faculdade de Medicina, Portugal
2013	Complicações macromoleculares da diabetes tipo 2: papel dos AGEs e do RAGE Presidente do júri	Daniela Sofia Lourenço Neto (Mestrado) Universidade de Coimbra - Faculdade de Medicina, Portugal
2013	O papel da piridoxamina na reversão da lesão renal induzida por metilglioxal Presidente do júri	Adriana Isabel Dias Roque (Mestrado) Universidade de Coimbra - Faculdade de Medicina, Portugal
2012	Sucrose-induced memory deficits Arguente principal	Edna Filipa Pais Soares (Mestrado) Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal
2011	O sistema somatossensitivo no rato com neuropatia diabética Arguente principal	Carla Sofia da Costa Morgado (Doutoramento) Universidade do Porto Faculdade de Medicina, Portugal
2008	Neurotoxicity induced by amyloid-beta: the role of different peptide assemblies Arguente	Rosa Maria Branco de Matos Resende (Doutoramento) Universidade de Coimbra - Faculdade de Medicina, Portugal

Arbitragem científica em conferência

	Nome da conferência	Local da conferência
2022/07/01 - 2022/07/02	36ª Reunião Anual do Grupo de Estudos de Envelhecimento Cerebral e Demência

Arbitragem científica em revista

	Nome da revista (ISSN)	Editora
2020/05 - Atual	Antioxidants & Redox Signaling (1557-7716)	Mary Ann Liebert
2018 - Atual	Journal of Alzheimer's Disease Reports	IOS Press
2018 - Atual	Diabetologia (1432-0428)	Springer-Verlag
2018 - Atual	Brain Behavior and Immunity (1090-2139)	Elsevier
2018 - Atual	Scientific Reports (2045-2322)	Springer Science and Business Media LLC
2018 - Atual	Cellular and Molecular Life Sciences (1420-9071)	Springer-Verlag
2018 - Atual	EClinicalMedicine (2589-5370)	Elsevier
2018 - Atual	Nature Reviews Neurology (1759-4766)	Springer Science and Business Media LLC
2018 - Atual	Neurotherapeutics (1878-7479)	Springer-Verlag
2017 - Atual	Progress in Neurobiology (0301-0082)	Elsevier
2017 - Atual	Alzheimers Disease & Dementia (2578-6490)	sPage.direcT
2017 - Atual	American Journal of Alzheimer s Disease (1082-5207)	SAGE Publications
2017 - Atual	Molecular Biology Reports (1573-4978)	Springer-Verlag
2016 - Atual	Rejuvenation Research (1557-8577)	Mary Ann Liebert
2016 - Atual	Diabetes Obesity and Metabolism (1463-1326)	Wiley (Blackwell Publishing)
2016 - Atual	Nature Reviews Endocrinology (1759-5037)	Springer Science and Business Media LLC
2016 - Atual	The Lancet Diabetes & Endocrinology (2213-8587)	Elsevier
2015 - Atual	PeerJ (2167-8359)	PeerJ
2015 - Atual	BioMed Research International (2314-6141)	Hindawi Limited
2015 - Atual	Current Alzheimer Research (1567-2050)	Bentham Science
2015 - Atual	Journal of Clinical Investigation (1558-8238)	American Society for Clinical Investigation
2015 - Atual	Medicinal Research Reviews (1098-1128)	Wiley (John Wiley & Sons)
2015 - Atual	Neuropathology and Applied Neurobiology (1365-2990)	Wiley (Blackwell Publishing)
2015 - Atual	Expert Opinion on Drug Discovery (1746-045X)	Informa UK (Taylor & Francis)
2015 - Atual	Molecular Neurobiology (0893-7648)	Springer-Verlag
2015 - Atual	Trends in Neurosciences (0166-2236)	Elsevier
2014 - Atual	Therapeutic Advances in Chronic Disease (2040-6231)	SAGE Publications
2014 - Atual	Neuropharmacology (0028-3908)	Elsevier
2014 - Atual	Aging Cell (1474-9728)	Wiley (Blackwell Publishing)
2014 - Atual	Trends in Biotechnology (0167-7799)	Elsevier
2013 - Atual	Expert Reviews in Molecular Medicine (1462-3994)	Cambridge University Press
2012 - Atual	Frontiers in Aging Neuroscience (1663-4365)	Frontiers Media SA
2012 - Atual	Diabetes
2012 - Atual	Neurobiology of Disease (1095-953X)	Elsevier
2012 - Atual	Neurobiology of Disease (1095-953X)	Elsevier
2012 - Atual	Free Radical Biology and Medicine (0891-5849)	Elsevier
2012 - Atual	Neuroendocrinology (1423-0194)	S. Karger AG
2012 - Atual	Biochemical Pharmacology (0006-2952)	Elsevier
2012 - Atual	Journal of Neurochemistry (1471-4159)	Wiley (Blackwell Publishing)
2010 - Atual	Journal of Alzheimer s Disease (1875-8908)	IOS Press
2010 - Atual	Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (0925-4439)	Elsevier
2010 - Atual	European Journal of Pharmacology (0014-2999)	Elsevier
2009 - Atual	Antioxidants & Redox Signaling (1557-7716)	Mary Ann Liebert
2009 - Atual	European Journal of Clinical Investigation (1365-2362)	Wiley (Blackwell Publishing)
2009 - Atual	Neurosciences (1658-3183)	Neurosciences
2008 - Atual	The FASEB Journal (1530-6860)	Federation of American Society for Experimental Biology
2005 - Atual	Experimental Neurology (1090-2430)	Elsevier
2004 - Atual	Expert Review of Neurotherapeutics (1744-8360)	Informa UK (Taylor & Francis)
2013 - 2019	British Journal of Pharmacology (1476-5381)	Wiley (Blackwell Publishing)

Comissão de avaliação

	Descrição da atividade Tipo de assessoria	Instituição / Organização	Entidade financiadora
2022 - Atual	2023 Pasqual Maragall Alzheimer Researchers Programme (PMRP) Avaliador	Generalitat de Catalunya Agència de Gestió d'Ajuts Universitaris i de Recerca, Espanha
2016 - Atual	Evaluator for European Science Foundation Avaliador	European Science Foundation, França
2024 - 2024	ERA4Health NutriBrain Joint Transnational Call	MUR - Ministero dell'Università e della Ricerca, Itália
2024 - 2024	Pathfinder Open call 2024 Avaliador
2021 - 2021	Evaluator of the reports submitted by Doctorate Researchers (Decreto-Lei n.º 57/2016) Avaliador	Faculty of Medicine, University of Coimbra, Portugal
2016 - 2021	Evaluator of the Marie Sklodowska-Curie Individual Fellowships (Life Sciences Panel) Avaliador	European Commission, Bélgica	European Commission
2016 - 2021	Evaluator of applications - Alzheimer's Association Research Grant Program Avaliador	Alzheimer's Association, Estados Unidos	Alzheimer's Association
2019/12 - 2020/12	Committee Member on Novo Nordisk Foundation Challenge Programme 2020 - Biomedicine and Health Sciences Avaliador	Novo Nordisk Fonden, Dinamarca	Novo Nordisk Fonden
2018 - 2018	Evaluator of applications within the call "What causes Brain Disease?" Avaliador	Lundbeckfonden, Dinamarca	Lundbeckfonden
2016 - 2018	Evaluator of applications submitted to ANR	Agence nationale de la recherche, França	Agence nationale de la recherche
2014 - 2015	Evaluator Post-Doctoral Fellowships (Experimental Biology and Biochemistry Panel) Avaliador	Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal), Portugal	Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)

Curso / Disciplina lecionado

	Disciplina	Curso (Tipo)	Instituição / Organização
2024 - Atual	Fundamentos de Fisiologia II - Curricular Unit Coordinator (Regência) Medicinal Chemistry Degree	Fundamentos de Fisiologia II	Universidade de Coimbra - Faculdade de Medicina, Portugal
2023 - Atual	Fundamentos de Fisiologia I - Curricular Unit Coordinator (Regência) Medicinal Chemistry Degree	Fundamentos de Fisiologia I (Licenciatura)	Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal
2020/05 - Atual	Fisiologia II	(Master Universitario)	Universidade de Cabo Verde, Cabo Verde
2012 - Atual	Fundamentos de Fisiologia II	Licenciatura em Química Medicinal (Licenciatura)	Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2011/02 - Atual	Fisiologia Humana Geral	Mestrado Integrado em Medicina Dentária (Mestrado integrado)	Universidade de Coimbra - Faculdade de Medicina, Portugal
2011 - Atual	Fundamentos de Fisiologia I	Licenciatura em Química Medicinal (Licenciatura)	Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009 - Atual	Fundamentos de Fisiologia II	Mestrado Integrado em Engenharia Biomédica (Mestrado integrado)	Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2008 - Atual	Fundamentos de Fisiologia I	Mestrado Integrado em Engenharia Biomédica (Mestrado integrado)	Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2006/02 - Atual	Fisiologia II	(Mestrado integrado)	Universidade de Coimbra - Faculdade de Medicina, Portugal
2005/12/01 - Atual	Fisiologia I	Mestrado Integrado em Medicina (Mestrado integrado)	Universidade de Coimbra - Faculdade de Medicina, Portugal
2023/04/03 - 2023/04/13	PHD Programme in Experimental Biology and Biomedicine - PDBEB	ONE HEALTH: A Metabolic Approach from the Cell to Society (Curso de doutoramento (conclusão de unidades curriculares))	Universidade de Coimbra - Centro de Neurociências e Biologia Celular, Portugal

Membro de associação

	Nome da associação	Tipo de participação
2022 - Atual	Portuguese Physiological Society	Member
2007 - Atual	Portuguese Society of Diabetology	Membro
2007 - Atual	European Association for the Study of Diabetes	Membro
2006 - Atual	Portuguese Society for Neuroscience	Membro

Membro de comissão

	Descrição da atividade Tipo de participação	Instituição / Organização
2022/07/18 - 2022/07/19	IRCND 2022 Long Range Planning Committee Membro
2019/05/22 - 2019/05/24	Scientific committee - 53rd Annual Meeting of the European Society for Clinical Investigation (ESCI) Membro	European Society for Clinical Investigation, Países Baixos
2018/07/13 - 2018/07/13	Scientific Committee - International Symposium; MitoPorto – Mitochondrial evolution, metabolism and disease Outro
2013/05/30 - 2013/06/01	Organizing committee - XIII Reunião da Sociedade Portuguesa de Neurociências Membro

Distinções

Prémio

2023	Rosalind Franklin Society Special Award in Science 2022 Rosalind Franklin Society , Estados Unidos Mary Ann Liebert Inc., Estados Unidos
2023	Honorable Mention Pedro Eurico Lisboa / SPD Sociedade Portuguesa de Diabetologia, Portugal
2017	Orlando Leitão Prize Sociedade Portuguesa de Neurologia, Portugal
2015	Mantero Belard Prize Santa Casa da Misericórdia de Lisboa, Portugal
2014	2nd prize for research project Sociedade Portuguesa de Diabetologia, Portugal
2013	Best Research Paper - Basic Science Universidade de Coimbra - Faculdade de Medicina, Portugal
2010	ASN Neuro Poster Prize American Society of Neurochemistry, Estados Unidos
2008	L'Oreal for Women in Science award L’Oreal Portugal , Portugal Comissão Nacional da UNESCO , Portugal Fundação para a Ciência e a Tecnologia, Portugal
2003	Stimulus to Research Prize Fundação Calouste Gulbenkian, Portugal
2003	Best Poster Prize Physiological Society, Reino Unido

Título

2022	Member of Global Association for the Study of Neurodegenerative Diseases
2021	Member of the Selection Committee Top 25 Outstanding Women Listeners 2021
2021	Member of Neurodegeneration Precision Medicine Initiative
2018	Member of the Dana Alliance for Brain Initiatives Dana Foundation, Estados Unidos
2018	Member of European Science Foundation (ESF) College of Expert Reviewers European Science Foundation, França

Outra distinção

2023	Research.com_ranked #4 in Portugal among Best Scientists in Biology and Biochemistry
2023	Research.com_ranked #9 in Portugal among Best Scientists in Medicine
2022	World's Top 2% Scientists 2022
2021	Expertscape World Expert in Mitochondria
2021	World's Top 2% Scientists 2021