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José C. Machado (JCM) is a Full Professor at the Faculty of Medicine of the University of Porto, Group Leader at i3S and a member of the Executive Committees of i3S and Ipatimup. He studied Biology at the University of Porto and developed his PhD at the Universities of Tubingen, Germany, and Porto, Portugal. JCM is best known for his scientific work on the role of Helicobacter pylori infection and E-cadherin in gastric cancer. He was a member of the scientific committees of UEG (United European Gastroenterology) and ESHG (European Society of Human Genetics). He was awarded the ECP (European Cancer Prevention Organization) Young Researcher Prize 2000, a Scholar-in-training Award for Promising Cancer Research from AACR in 2001, the National Gastroenterology Prize 2005, and the Pfizer Clinical Research Prize 2018. JCM was also the head of the molecular diagnostics laboratory of IPATIMUP. As of March 2024, JCM is a co-author of 200 scientific publications, with a total number of citations over 15000 and an h-index of 50 (Scopus Author ID: 7102792651).
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Identificação

Identificação pessoal

Nome completo
José Carlos Lemos Machado

Nomes de citação

  • Machado, José Carlos

Identificadores de autor

Ciência ID
A511-FB77-A15F
ORCID iD
0000-0003-4741-8415
Researcher Id
C-5907-2009
Scopus Author Id
7102792651

Endereços de correio eletrónico

  • josem@i3s.up.pt (Profissional)
  • josem@med.up.pt (Profissional)
  • josem@i3s.up.pt (Profissional)
  • joseclm1969@gmail.com (Pessoal)

Telefones

Telefone
  • 225570796 (Profissional)

Moradas

  • Rua Alfredo Allen, 208, 4200-135, Porto, Porto, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Português Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Espanhol; Castelhano Utilizador independente (B1) Utilizador independente (B1) Utilizador elementar (A1) Utilizador independente (B1)
Formação
Grau Classificação
2020/01/22
Concluído
 Biomedicina (Título de Agregado)
Universidade do Porto Faculdade de Medicina, Portugal
1999
Concluído
 Biologia Humana (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
 Aprovado (classificação máxima)
1994
Concluído
 Oncobiologia (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
 Muito Bom por Unanimidade
1992
Concluído
 Biologia (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
Percurso profissional

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2021/10/01 - Atual Professor Catedrático (Docente Universitário) Universidade do Porto Faculdade de Medicina, Portugal
Universidade do Porto Faculdade de Medicina, Portugal
2007/06/18 - 2021/09/30 Professor Associado (Docente Universitário) Universidade do Porto, Portugal
2001/11/01 - 2007/06/17 Professor Auxiliar (Docente Universitário) Universidade do Porto, Portugal
Universidade do Porto Faculdade de Medicina, Portugal

Cargos e Funções

Categoria Profissional
Instituição de acolhimento 		Empregador
2018 - Atual Member of the Board of Directors Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2014 - Atual Conselho científico/técnico-científico ou orgão correspondente Universidade do Porto, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2015/01/01 - Atual Principal Investigator (Group coordinator) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2004/01/01 - 2017/12/31 Director of the Genetic Diagnostics Laboratory at Ipatimup Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
1999/05/01 - 2001/10/31 Post-Doctoral Fellow Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
1994/12/01 - 1999/04/30 PhD Student Universidade do Porto Faculdade de Medicina, Portugal
1992/11/01 - 1994/11/30 MSc Student Universidade do Porto Faculdade de Medicina, Portugal
1991/01/01 - 1992/07/31 Young Researcher Fellowship Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Projetos

Projeto

Designação Financiadores
2021/01/01 - 2025/12/31 Institute for Research and Innovation in Health
LA/P/0070/2020
Instituto Nacional de Engenharia Biomédica, Portugal

Universidade do Porto, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2022/01/01 - 2024/12/31 Circulating Microbial Signatures for Early Diagnosis of Cancer
PTDC/BTM-TEC/0367/2021
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Instituto de Engenharia de Sistemas e Computadores Tecnologia e Ciência, Portugal

Centro Hospitalar Universitário de São João, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2022/01/01 - 2023/06/30 Glycosylation and cancer: immunosurveillance’s sweet spot
EXPL/MED-ONC/1592/2021
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2018/10/01 - 2022/09/30 Early molecular bases for the diagnosis and treatment of adrenocortical tumors in the era of personalized medicine
PTDC/MEC-ONC/31384/2017
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2018 - 2021/09/30 Molecular bases for the early diagnosis and treatment of adrenocortical tumors in the era of personalized medicine
PTDC/MEC-ONC/31384/2017
Investigador
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2018/07/26 - 2021/07/25 Neoantigen signature algorithm to predict immunotherapy response
PTDC/MEC-ONC/32018/2017
Investigador
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2018 - 2021/07/25 Tregs in cancer immune response
PTDC/MED-PAT/32462/2017
Investigador responsável
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2018 - 2021/07/25 Lung Cancer Screening - A non-invasive methodology for early diagnosis
PTDC/EMD-EMD/30263/2017
Investigador
Instituto de Engenharia de Sistemas e Computadores Tecnologia e Ciência, Portugal

Universidade do Porto, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2018/07/01 - 2021/06/30 Microbiome-derived metabolites as new gastric cancer biomarkers
PTDC/MED-OUT/32532/2017
Investigador
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2017/10/16 - 2020/01/16 Test strips for biomarker screening of venous thromboembolism in oncology
SAICT-POL/24358/2016
Investigador
Instituto Politécnico do Porto Instituto Superior de Engenharia do Porto, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

International Iberian Nanotechnology Laboratory, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2019/01/01 - 2019/12/31 Institute for Research and Innovation in Health Sciences
UID/BIM/04293/2019
Instituto de Astrofísica e Ciências do Espaço, Portugal

Universidade do Porto, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Instituto Nacional de Engenharia Biomédica, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2015 - 2019/09/01 Horizontal transmission of drug resistance: a game changer in the clinical management of cancer patients
PTDC/DTP-PIC/2500/2014
Investigador
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2015 - 2019/07/31 The yin and yang of somatic mutations in cancer immuno surveillance
PTDC/BIM-MEC/2834/2014
Investigador responsável
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2015 - 2019 Advancing cancer research: from basic knowledge to application
NORTE-01-0145-FEDER-000029
Investigador responsável
Comissao de Coordenacao e Desenvolvimento Regional do Norte
Em curso
2015 - 2018 Gastric microbiota & cancer: more than Helicobacter pylori
16-1352
Investigador
Worldwide Cancer Research
Concluído
2015 - 2017 Mutation detection in the plasma of lung cancer patients
FIS-FIS-2015-01_ONC_20150630-177
Investigador responsável
Infarmed Autoridade Nacional do Medicamento e Produtos de Saúde IP
Concluído
2013/05/01 - 2015/10/31 Portuguese study of familial dilated cardiomyopathies
PTDC/BIM-MEC/0650/2012
Sociedade Portuguesa de Cardiologia, Portugal

Universidade do Porto Unidade de Investigação e Desenvolvimento Cardiovascular, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2012/03/01 - 2015/06/30 Unravelling a new Helicobacter pylori virulence factor involved in tight junction dysfunction
PTDC/BIA-MIC/116890/2010
info:eu-repo/grantAgreement/FCT/COMPETE/116890/PT
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2012/03/01 - 2015 Helicobacter pylori genetic variation: An opportunity to identify individuals at increased risk for disease
info:eu-repo/grantAgreement/FCT/COMPETE/120024/PT
PTDC/SAU-SAP/120024/2010
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Hospital de São João, Portugal

Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2012/03/01 - 2015 PYLORICIDAL - Engineered biomaterials with Helicobacter PYLORI bacteriCIDAL effect
info:eu-repo/grantAgreement/FCT/COMPETE/121149/PT
PTDC/CTM-BPC/121149/2010
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2011/03/01 - 2014 Helicobacter pylori diversity in pathogenesis, antibiotic resistance, and evasion from natural and vaccine-induced immune responses (HELDIVPAT)
info:eu-repo/grantAgreement/FCT/3599-PPCDT/116470/PT
ERA-PTG/0001/2010
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2011 - 2014 Desenvolvimento de um novo método de detecção de mutações com relevância preditiva na resposta de doentes com carcinoma colo-rectal ao tratamento com cetuximab
Anti-EGFR Effective
Investigador responsável
Agência Nacional de Inovação SA
Concluído
2011/01/01 - 2012/12/31 Projecto Estratégico - LA 3 - 2011-2012
PEst-C/SAU/LA0003/2011
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2010 - 2012 Biomarcadores de resposta à terapía em doentes com carcinoma colo-rectal metastático na população Portuguesa
PPS5 Consórcio DoIT
Investigador responsável
Agência Nacional de Inovação SA
Concluído
2009 - 2012 Development of a medical information system about Hereditary Breast and Colorectal cancer
HMSP-IDSIM/SIM/0013/2009
Investigador
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Universidade do Porto Faculdade de Medicina, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2008/02/01 - 2011/04/30 Exploring the role of E-cadherin trafficking deregulation in epithelial cancer progression.
PTDC/SAU-OBD/64319/2006
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2007 - 2011 Evaluation and Control of Neglected Mucosal Enteric Infections in Childhood
INCO Contract Number 032136
 European Commission
Concluído
2007/02/01 - 2010/01/31 Parasite and host genetic diversity in Helicobacter infections (HELDIVNET)
ERA-PTG/0004/2006
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2006 - 2010 The role of chronic infections in the development of cancer
INCA Proposal/Contract no.: 018704
INCA ¿ Proposal/Contract no.: 018704
Investigador
European Commission
Concluído
2005/07/01 - 2008/06/30 Effects of Helicobacter pylori on gastric epithelial cells
POCI/SAU-IMI/56681/2004
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2005/09/01 - 2008/04/30 Characterization of nine members of the major outer membrane proteins family in Helicobacter pylori strains isolated from Portuguese patients
POCI/SAU-IMI/57297/2004
Universidade do Algarve, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2002 - 2005 Teste de susceptibilidade genética para determinação de risco de desenvolvimento de Doença de Crohn na população Portuguesa
TSG-CROHN
Investigador responsável
Agência Nacional de Inovação SA
Concluído
2001 - 2004 Helicobacter pylori virulence and interleukin-1 polymorphisms: interplay in gastric carcinogenesis
POCTI/CBO/41550/2001
Investigador responsável
Fundação para a Ciência e a Tecnologia
Concluído
2001 - 2004 Identification of genetic markers for risk of development of gastric carcinoma in the Portuguese population
SIFEC nº 15-01-01-FDR-00158
Investigador responsável
Associação Portuguesa da Indústria Farmacêutica
Concluído
1999 - 2002 Molecular genetic characterization of mixed carcinomas of the stomach: implications for phenotypic divergence and biological aggressiveness
POCTI/1999/MGI/35586
Investigador
Fundação para a Ciência e a Tecnologia
Concluído
2000/01/01 - 2001/12/31 CHARACTERISATION OF THE MOLECULAR FEATURES UNDERLYING THE PHENOTYPIC DIVERGENCE AND BIOLOGICAL AGGRESSIVENESS OF MIXED GASTRIC CARCINOMAS
PRAXIS XXI/BPD/22083/99
 Fundação para a Ciência e a Tecnologia
Concluído
1994/11/01 - 1998/10/31 PATTERNS OF TREFOIL PEPTIDES EXPRESSION IN GASTRO-INTESTINAL CANCER
PRAXIS XXI/BD/3271/94
 Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em conferência
  1. Simões, Miguel; Pereira, Tania; Silva, Francisco; Machado, José Carlos; Oliveira, Hélder P.. "A Machine Learning Approach for Predicting Microsatellite Instability using RNA-seq". 2023.
    10.1109/bibm58861.2023.10385571
  2. Junqueira-Neto, Susana; Oliveira, Ana Rita; Marques, Joana; Melo, Sónia; Costa, José Luís; Machado, José Carlos. "Abstract 1099: Resistance to anti-EGFR therapy can spread horizontally among cancer cells". Trabalho apresentado em AACR 2021, 2021.
    10.1158/1538-7445.am2021-1099
  3. Marta Laranjeiro Pinto; Durães, Cecília; Ricardo Ribeiro; Machado, José Carlos; Mantovani, Alberto; Adolfo Barbosa, Mário; Carneiro, Fatima; Maria José Oliveira. "Profiling macrophage populations in human colorectal cancer". Trabalho apresentado em 8th International Conference on Tumor Microenvironment: Progression, Therapy & Prevention, Lisbon, 2018.
    Publicado
  4. Fevereiro, B; Goncalves, FR; Torres Guimaraes, B; Tomaz, DF; Vasconcelos Oliveira, AC; Machado, JC; Severo, M. "THE IMPACT ON THE QUALITY AND SATISFACTION OF THE TESTS OF AN UNCUED QUESTION FORMAT VERSUS A SHORT ANSWER QUESTION FORMAT". 2016.
  5. Seabra, Catarina Leal; Nunes, Cláudia; Gomes-Lázaro, Maria; Correia, Marta; Machado, José Carlos; Gonçalves, Inês; Reis, Celso A.; Reis, Salette; Martins, M.C.L.. "Anti-Helicobacter pylori activity of lipid nanoparticles loaded with an omega-3 polyunsaturated fatty acid". Trabalho apresentado em 29th International Workshop on Helicobacter and Microbiota in Inflammation and Cancer (EHMSG), 2016.
    Publicado
  6. Regalo, G; Resende, Carlos; Wen, X; Suriano, G; Oliveira, Maria; Figueiredo, Ceu; Seruca, Raquel; Carneiro, Fatima; Machado, José Carlos. "C/EBPalpha is down-regulated in gastric carcinogenesis and is associated with decreased proliferation of gastric carcinoma cells". Trabalho apresentado em XX International Workshop of the European Helicobacter Study Group, Istanbul, 2007.
    Publicado
Artigo em revista
  1. José Pedro Santos; Joana Figueiredo; José Carlos Machado. "Gastric Cancer Genetics and Its Implications for Diagnosis, Prognosis, and Treatment of the Disease". The Korean Journal of Helicobacter and Upper Gastrointestinal Research (2024): https://doi.org/10.7704/kjhugr.2024.0018.
    10.7704/kjhugr.2024.0018
  2. Vincent D. de Jager; Wim Timens; Arnaud Bayle; Johan Botling; Luka Brcic; Reinhard Büttner; Maria Gabriela O. Fernandes; et al. "Future perspective for the application of predictive biomarker testing in advanced stage non-small cell lung cancer". The Lancet Regional Health - Europe (2024): http://dx.doi.org/10.1016/j.lanepe.2024.100839.
    10.1016/j.lanepe.2024.100839
  3. Vincent D. de Jager; Wim Timens; Arnaud Bayle; Johan Botling; Luka Brcic; Reinhard Büttner; Maria Gabriela O. Fernandes; et al. "Developments in predictive biomarker testing and targeted therapy in advanced stage non-small cell lung cancer and their application across European countries". The Lancet Regional Health - Europe (2024): http://dx.doi.org/10.1016/j.lanepe.2024.100838.
    10.1016/j.lanepe.2024.100838
  4. Pereira J; Melo S; Ferreira RM; Carneiro P; Yang V; Maia AF; Carvalho J; et al. "E-cadherin variants associated with oral facial clefts trigger aberrant cell motility in a REG1A-dependent manner.". Cell communication and signaling : CCS (2024): https://doi.org/10.1186/s12964-024-01532-x.
    10.1186/s12964-024-01532-x
  5. Adem B; Bastos N; Ruivo CF; Sara Sousa Alves; Carolina Dias; Patrícia Vieira; Ines Batista; et al. "Exosomes define a local and systemic communication network in healthy pancreas and pancreatic ductal adenocarcinoma.". Nature communications (2024): https://europepmc.org/articles/PMC10881969.
    10.1038/s41467-024-45753-7
  6. Jose Machado. "Next-Generation Sequencing (NGS) in lung cancer care: Advantages, applications, and challenges". Revista do Grupo de Estudos do Cancro do Pulmão (2023): https://doi.org/10.32932/gecp.2023.12.047.
    10.32932/gecp.2023.12.047
  7. Bujanda L; Nyssen OP; Ramos J; Bordin DS; Tepes B; Perez-Aisa A; Pavoni M; et al. "Effectiveness of Helicobacter pylori treatments according to antibiotic resistance.". The American journal of gastroenterology (2023): http://europepmc.org/abstract/med/37983769.
    10.14309/ajg.0000000000002600
  8. Nicola Normanno; José Carlos Machado; Edoardo Pescarmona; Simonetta Buglioni; Lara Navarro; Riziero Esposito Abate; Anabela Ferro; et al. "European Real-World Assessment of the Clinical Validity of a CE-IVD Panel for Ultra-Fast Next-Generation Sequencing in Solid Tumors". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms241813788.
    10.3390/ijms241813788
  9. Alexandra Mesquita; Anabela Ferro; José Carlos Machado; Fernando Schmitt. "Next-Generation Sequencing of Breast Cancer in the Neoadjuvant Setting". Pathobiology (2023): http://dx.doi.org/10.1159/000533810.
    10.1159/000533810
  10. Joana Espiga de Macedo Macedo; Tiago Taveira-Gomes; José Carlos Machado; Venceslau Hespanhol. "Implementation of a Pilot Study to Analyze Circulating Tumor DNA in Early-Stage Lung Cancer". Acta Médica Portuguesa (2023): https://doi.org/10.20344/amp.19487.
    10.20344/amp.19487
  11. Marina Morais; Telma Fonseca; Diogo Melo-Pinto; Isabel Prieto; Ana Teresa Vilares; Ana Luísa Duarte; Patrícia Leitão; et al. "Evaluation of ctDNA in the Prediction of Response to Neoadjuvant Therapy and Prognosis in Locally Advanced Rectal Cancer Patients: A Prospective Study". Pharmaceuticals (2023): https://doi.org/10.3390/ph16030427.
    10.3390/ph16030427
  12. Peixoto, A.; Cirnes, L.; Carvalho, A.L.; Andrade, M.J.; Brito, M.J.; Borralho, P.; Borralho, P.M.; et al. "Evaluation of PIK3CA mutations in advanced ER+/HER2-breast cancer in Portugal – U-PIK Project". Frontiers in Molecular Biosciences 10 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85148532448&partnerID=MN8TOARS.
    10.3389/fmolb.2023.1082915
  13. Bastos, N.; Castaldo, S.A.; Adem, B.; Machado, J.C.; Melo, C.A.; Melo, S.A.. "SMC3 epigenetic silencing regulates Rab27a expression and drives pancreatic cancer progression". Journal of Translational Medicine 21 1 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85168891055&partnerID=MN8TOARS.
    10.1186/s12967-023-04448-1
  14. Thorell, K.; Muñoz-Ramírez, Z.Y.; Wang, D.; Sandoval-Motta, S.; Boscolo Agostini, R.; Ghirotto, S.; Torres, R.C.; et al. "The Helicobacter pylori Genome Project: insights into H. pylori population structure from analysis of a worldwide collection of complete genomes". Nature Communications 14 1 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85179650185&partnerID=MN8TOARS.
    10.1038/s41467-023-43562-y
  15. M. Costa e Silva; I. Sucena; L. Cirnes; J.C. Machado; S. Campainha; A. Barroso. "KIF5B-MET fusion variant in non-small cell lung cancer". Pulmonology (2022): https://doi.org/10.1016/j.pulmoe.2022.02.001.
    10.1016/j.pulmoe.2022.02.001
  16. "Extracellular Vesicles from Pancreatic Cancer Stem Cells Lead an Intratumor Communication Network (EVNet) to fuel tumour progression". Gut (2022): gutjnl--2021--324994-gutjnl--2021--324994. http://dx.doi.org/10.1136/gutjnl-2021-324994.
    10.1136/gutjnl-2021-324994
  17. Morais, M.; Pinto, D.M.; Machado, J.C.; Carneiro, S.. "ctDNA on liquid biopsy for predicting response and prognosis in locally advanced rectal cancer: A systematic review". European Journal of Surgical Oncology 48 1 (2022): 218-227. http://www.scopus.com/inward/record.url?eid=2-s2.0-85114698880&partnerID=MN8TOARS.
    10.1016/j.ejso.2021.08.034
  18. Teixeira, MR; Oliveira, J; Borralho, P; Fernandes, MGO; Almodovar, T; Fernandes, I; Macedo, D; et al. "Portuguese Consensus Recommendations for Next-Generation Sequencing of Lung Cancer, Rare Tumors, and Cancers of Unknown Primary Origin in Clinical Practice". ACTA MEDICA PORTUGUESA (2022):
    10.20344/amp.17680
  19. Malfertheiner, P.; Megraud, F.; Rokkas, T.; Gisbert, J.P.; Liou, J.-M.; Schulz, C.; Gasbarrini, A.; et al. "Management of Helicobacter pylori infection: the Maastricht VI/Florence consensus report". Gut 71 9 (2022): 1724-1762. http://www.scopus.com/inward/record.url?eid=2-s2.0-85137345984&partnerID=MN8TOARS.
    10.1136/gutjnl-2022-327745
  20. JA Freitas; Irene Gullo; Diogo Garcia; Sara Miranda; Louisa Spaans; Lídia Pinho; Joana Pereira Reis; et al. "The Adaptive Immune Landscape of the Colorectal Adenoma–Carcinoma Sequence". International Journal of Molecular Sciences (2021): https://www.mdpi.com/1422-0067/22/18/9791.
    10.3390/ijms22189791
  21. Francesca Fenizia; Ilaria Alborelli; Jose Luis Costa; Claudia Vollbrecht; Beatriz Bellosillo; Winand Dinjens; Volker Endris; et al. "Validation of a Targeted Next-Generation Sequencing Panel for Tumor Mutation Burden Analysis". The Journal of Molecular Diagnostics 23 7 (2021): 882-893. https://doi.org/10.1016/j.jmoldx.2021.04.008.
    10.1016/j.jmoldx.2021.04.008
  22. Nyssen, OP; Bordin, D; Tepes, B; Perez Aisa, A; Vaira, D; Caldas, M; Bujanda, L; et al. "European Registry on Helicobacter pylori management (Hp--EuReg): patterns and trends in first-line empirical eradication prescription and outcomes of 5 years and 21 533 patients". GUT (2021):
    10.1136/gutjnl-2020-321372
  23. Pereira-Marques, J.; Ferreira, R.M.; Machado, J.C.; Figueiredo, C.. "The influence of the gastric microbiota in gastric cancer development". Best Practice and Research: Clinical Gastroenterology (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85101499383&partnerID=MN8TOARS.
    10.1016/j.bpg.2021.101734
  24. Fernandes, M.G.O.; Sousa, C.; Reis, J.P.; Cruz-Martins, N.; Moura, C.S.; Guimarães, S.; Justino, A.; et al. "Liquid biopsy for disease monitoring in non-small cell lung cancer: The link between biology and the clinic". Cells 10 8 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85115044336&partnerID=MN8TOARS.
    10.3390/cells10081912
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  147. Figueiredo, C.; Machado, J.C.; Yamaoka, Y.. "Pathogenesis of Helicobacter pylori infection". Helicobacter, Supplement 10 1 (2005): 14-20. http://www.scopus.com/inward/record.url?eid=2-s2.0-25844528219&partnerID=MN8TOARS.
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  177. Branco, M.; Machado, J.C.; Ferrand, N.. "Extensive genetic polymorphism of peptidases A, B, C, and D, in wild rabbit (Oryctolagus cuniculus) populations from the Iberian Peninsula". Biochemical Genetics 37 7-8 (1999): 237-249. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032705179&partnerID=MN8TOARS.
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  179. Labouvie, C.; Machado, J.C.; Carneiro, F.; Sarbia, M.; Vieth, M.; Porschen, R.; Seitz, G.; Blin, N.. "Differential expression of mucins and trefoil peptides in native epithelium, Barrett's metaplasia and squamous cell carcinoma of the oesophagus". Journal of Cancer Research and Clinical Oncology 125 2 (1999): 71-76. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032960551&partnerID=MN8TOARS.
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  181. Dos Santos Silva, E.; Kayademir, T.; Regateiro, F.; Machado, J.C.; Savas, S.; Dobosz, T.; Blin, N.; Gött, P.. "Variable distribution of TFF2 (Spasmolysin) alleles in Europeans does not indicate predisposition to gastric cancer". Human Heredity 49 1 (1999): 45-47. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032971007&partnerID=MN8TOARS.
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  182. Kayademir, T.; Dos Santos Silva, E.; Pusch, C.; Beck, S.; Machado, J.-C.; Gott, P.. "A novel 25 bp tandem repeat within the human trefoil peptide gene TFF2 in 21q22.3: Polymorphism and mammalian evolution". European Journal of Human Genetics 6 2 (1998): 121-128. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031958694&partnerID=MN8TOARS.
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Livro
  1. Figueiredo, C.; Constanza Camargo, M.; Leite, M.; Fuentes-Pananá, E.M.; Rabkin, C.S.; Machado, J.C.. Pathogenesis of gastric cancer: Genetics and molecular classification. 2017.
    10.1007/978-3-319-50520-6_12
  2. Figueiredo, C.; Camargo, M.C.; Leite, M.; Fuentes-Pananá, E.M.; Rabkin, C.S.; Machado, J.C.. Erratum to: Pathogenesis of Gastric Cancer: Genetics and Molecular Classification (molecular pathogenesis and signal transduction by helicobacter pylori, 10.1007/978-3-319-50520-6_12). 2017.
    10.1007/978-3-319-50520-6_15
Poster em conferência
  1. Pereira, João Luís; Francisca Ferreira; Matos, Andreia; Pereira, Dulcineia; Santos, Rita F; Alexandre M Carmo; Maria José Oliveira; Machado, José Carlos; dos Santos, Nuno R.. "Antibody blockade of PSGL-1, a novel immune checkpoint protein, enhances T cell activation against B-cell lymphoma". Trabalho apresentado em ESH 7th Translational Research Conference Lymphoid Malignancies, 2023.
  2. Pereira, João Luís; Ferreira, Francisca; Matos, Andreia; Pereira, Dulcineia; Santos, Rita F; Alexandre M Carmo; Maria José Oliveira; Machado, José Carlos; dos Santos, Nuno R.. "O bloqueio por anticorpo da glicoproteína PSGL-1, um novo checkpoint imunitário, facilita a ativação de células T contra linfoma". Trabalho apresentado em 5º Encontro Nacional de Jovens Investigadores em Oncologia, 2023.
  3. Pereira, João Luís; Francisca Ferreira; Matos, Andreia; Pereira, Dulcineia; Santos, Rita F; Alexandre M Carmo; Maria José Oliveira; Machado, José Carlos; dos Santos, Nuno R.. "Antibody blockade of PSGL-1, a novel immune checkpoint protein, enhances human T cell activation against lymphoma cells". Trabalho apresentado em EACR 2023 Congress: Innovative Cancer Science, 2023.
  4. Fernandes, Ângela; C Silva, Mariana; Resende, Carlos; Correia, Alexandra; Henrique, Rui M; Dinis-Ribeiro, Mário; Marcos-Pinto, Ricardo; Machado, José Carlos; Pinho, Salomé S. "The glyco-code in colorectal cancer immunoediting: glycans as novel immune checkpoints". Trabalho apresentado em XXIX Porto Cancer Meeting, 2023.
  5. Resende, Carlos; Xavier-Ferreira, Helena; Vilarinho, Ana; Gomes, Joana; Rodrigues, Joana; Cavadas, Bruno; Reis, Celso; Machado, José Carlos. "New evidences linking immunity, tumor development and tumor-associated glycosylation in a preclinical model of intestinal tumorigenesis". Trabalho apresentado em XXIX Porto Cancer Meeting, 2023.
  6. Pereira, João Luís; Ferreira, Francisca ; Matos, Andreia; Pereira, Dulcineia; Santos, Rita F; Alexandre M Carmo; Maria José Oliveira; Machado, José Carlos; dos Santos, Nuno R.. "PSGL-1 antibody blockade enhances human T cell activation against lymphoma cells". Trabalho apresentado em XLVIII Annual Meeting Portuguese Society for Immunology, 2023.
  7. Vilarinho, Ana; Resende, Carlos; Xavier-Ferreira, Helena; Cavadas, Bruno; Machado, José Carlos. "THE INTERPLAY BETWEEN SOMATIC MUTATIONS AND CANCER IMMUNOSURVEILLANCE: A MOUSE STORY". Trabalho apresentado em 4th SPLC-CRS Young Scientists Meeting, 2023.
  8. Pereira, João Luís; Santos, Rita F; Carmo, Alexandre; Machado, José Carlos; dos Santos, Nuno R.. "Antibody blockade of the PSGL-1 checkpoint regulator promotes human T cell responses against lymphoma cells". Trabalho apresentado em 5th ASPIC International Congress, 2022.
  9. Vieira, Patricia; Pereira-Marques, Joana; Ferreira, Rui M.; Machado, José Carlos; Figueiredo, Ceu. "The love affair between the microbiome, the immune response, and colorectal cancer.". Trabalho apresentado em 8th Porto Cancer Meeting | Extracellular Vesicles, Cell Communication and Cancer, 2022.
  10. Vieira, Patricia; Pereira-Marques, Joana; Ferreira, Rui M.; Machado, José Carlos; Figueiredo, Ceu. "Microbiome, immune response, and cancer: a game changer triad in colorectal cance". Trabalho apresentado em 4th PhDay: Break Borders and Build Opportunities, 2021.
  11. Resende, Carlos; Gomes, Joana; Rodrigues, Joana; Costa, José Luís; Reis, Celso; Machado, José Carlos. "Immunity and tumor development: new evidences from preclinical models". Trabalho apresentado em EACR-AACR-ASPIC 2020 Conference: Tumor Microenvironment in Lisbon, Portugal from 02 to 04 March 2020, 2020.
  12. Seabra, Catarina Leal; Nunes, Cláudia; Parreira, Paula; Henriques, Patrícia; Monteiro, Claudia; Gomes-Lázaro, Maria; Brás, Manuela; et al. "Lipid-based nanoparticles to fight Helicobacter pylori gastric infection". Trabalho apresentado em 6th Annual Meeting, 2017.
  13. Correia, Marta; Seabra, Catarina Leal; Nunes, Cláudia; Parreira, Paula; Henriques, Patrícia; Monteiro, Claudia; Gomes-Lázaro, Maria; et al. "Lipid-based nanoparticles to fight H. pylori infections". Trabalho apresentado em I3S science retreat, 2017.
  14. Seabra, Catarina Leal; Nunes, Cláudia; Gomes-Lázaro, Maria; Correia, Marta; Machado, José Carlos; Gonçalves, Inês; Reis, Celso A.; Reis, Salette; Martins, M.C.L.. "Effect of docosahexaenoic acid loaded nanoparticles on the growth of Helicobacter pylori in vitro". Trabalho apresentado em BioImaging 2016 - 5th International Symposium in Applied Bioimaging: Disease in focus, 2016.
  15. Silva, Miguel; Resende, Carlos; Barranha, Rui; Justino, Ana; Meireles, Sara; Carneiro, Fatima; Machado, José Carlos; Costa, José Luís. "Colorectal intratumoral genetic heterogeneity: a pilot study". Trabalho apresentado em XXIII Porto Cancer Meeting - Stem Cells and Cancer, 2015.
  16. Teixeira, Ana Luísa; Dias, Francisca; Ferreira, Marta; Santos, Juliana Inês; Gomes, Mónica; Lobo, Francisco; Maurício, Joaquina; Machado, José Carlos; Medeiros, Rui. "Influence of EGF+61G>A and TGFB+869T>C polymorphisms in renal cell carcinoma development: the link to circulating microRNAs". Trabalho apresentado em 1st ASPIC Internacional Congress, 2015.
  17. Seabra, Catarina Leal; Nunes, Cláudia; Reis, Salette; Correia, Marta; Machado, José Carlos; Reis, Celso A.; Gonçalves, Inês; Martins, M.C.L.. "Docosahexaenoic acid delivery system for H. pylori infection treatment". Trabalho apresentado em 4th i3S Annual Meeting, 2014.
  18. Teixeira, Ana Luísa; Dias, Francisca; Ferreira, Marta; Santos, Juliana Inês; Gomes, Mónica; Lobo, Francisco; Maurício, Joaquina; Machado, José Carlos; Medeiros, Rui. "Synergistic influence of EGF+61G>A and TGFB+869T>C polymorphisms in renal cell carcinoma progression and overall survival: the link to plasma circulating microRNAs". Trabalho apresentado em 7th Santorini Conference: ¿Systems Medicine, Personalized Health and Therapy, 2014.
Pré-impressão
  1. Santos, Nuno Rodrigues dos; Pereira, João; Ferreira, Francisca; Matos, Andreia; Pereira, Dulcineia; Santos, Rita; Carmo, Alexandre; Oliveira, Maria; Machado, José Carlos. "Antibody blockade of the PSGL-1 immune checkpoint enhances T-cell responses to B-cell lymphoma". 2024. http://dx.doi.org/10.21203/rs.3.rs-4018077/v1.
    10.21203/rs.3.rs-4018077/v1
  2. "Resistance to EGFR inhibitors in lung cancer occurs through horizontal transfer and is associated with increased caveolins expression". 2022. http://dx.doi.org/10.1101/2022.02.20.481179.
    10.1101/2022.02.20.481179
Resumo em conferência
  1. Lima, J; Pinheiro, J; Nunes, S; Fernandes, AP; Soares, P; Machado, JC; Pereira, J; da Costa, MJG. "NGS MOLECULAR PROFILE OF PAEDIATRIC BRAIN TUMOURS: RESULTS FROM 92 CONSECUTIVE PATIENTS TREATED AT CENTRO HOSPITALAR UNIVERSITARIO DE SAO JOAO". 2022.
  2. Freitas, João A.; Carla P. Gomes; Helena Xavier-Ferreira; Carlos Resende; Machado, José Carlos. "REGULATORY T CELLS CHARACTERISATION IN MURINE TUMOURS". Trabalho apresentado em 14th YES Meeting, Porto, 2019.
    Publicado
  3. McNicholl, AG; Nyssen, OP; Bordin, DS; Tepes, B; Perez Aisa, A; Vaira, D; Caldas, M; et al. "Pan-European Registry on H. pylori management (Hp-EuReg): Impact of resistance on efficacy". 2018.
  4. McNicholl, AG; Nyssen, OP; Bordin, DS; Tepes, B; Perez Aisa, A; Vaira, D; Caldas, M; et al. "Pan-European Registry on H. pylori management (Hp-EuReg): Experience with single capsule bismuth quadruple therapy in 1200 patients". 2018.
  5. Machado, JC; Reis, J; Fernandes, M; Silva, R; Cirnes, L; Carneiro, F; Costa, JL. "Tumor-specific neoantigens drive T-cell clonotype convergence". 2018.
  6. Machado, JC; Reis, J; Fernandes, M; Silva, R; Cirnes, L; Chaudhary, R; Carneiro, F; Costa, JL. "Determining tumor mutation load using an NGS-based, target gene panel". 2018.
  7. Nyssen, OP; McNicholl, AG; Vaira, D; Perez Aisa, A; Caldas, M; Tepes, B; Bordin, D; et al. "Pan-European Registry on H. pylori management (Hp-EuReg): analysis of 3532 second-line treatments". 2018.
  8. McNicholl, AG; Nyssen, OP; Bordin, DS; Tepes, B; Perez Aisa, A; Vaira, D; Caldas, M; et al. "Pan-European Registry on H. pylori management (Hp-EuReg): interim analysis of 16 600 first-line treatments". 2018.
  9. McNicholl, AG; Nyssen, OP; Bordin, D; Tepes, B; Perez Aisa, A; Vaira, D; Bujanda, L; et al. "Pan-European Registry on H. pylori management (Hp-EuReg): bacterial resistance of 2684 H. pylori isolates". 2018.
  10. McNicholl, AG; Nyssen, OP; Bordin, DS; Tepes, B; Perez Aisa, A; Vaira, D; Caldas, M; et al. "Pan-European Registry on H. pylori Management (Hp-EuReg): first-line treatment use and efficacy trends from 2013 to 2018". 2018.
  11. Moutinho Ribeiro, P; Santos, A; Batista, I; Adem, B; Silva, S; Morais, R; Coelho, R; et al. "Exosomal Glypican-1 and Pancreatic Adenocarcinoma: Prime Time for Early Diagnosis?". 2018.
  12. Machado, JC; Reis, J; Fernandes, M; Silva, R; Cirnes, L; Carneiro, F; Costa, JL. "T-cell clonotype convergence in colorectal cancer driven by tumor-specific neoantigens". 2018.
    10.1158/1538-7445.am2018-136
  13. Fernandes, MG; Costa, J; Reis, J; Jacob, M; Moura, C; Machado, J; Hespanhol, V. "BRAF-V600E Advanced Lung Adenocarcinoma with Leptomeningeal (LM) Disease Treated with Vemurafenib". 2017.
  14. Oliveira, J; Egas, C; Machado, JC; Sousa, M; Santos, R. "The genetics of hereditary myopathies revisited by massive parallel sequencing". 2016.
  15. Sousa, A; Canedo, P; Moura, B; Lopes, L; Azevedo, O; Amorim, S; Rocha Goncalves, FR; et al. "Clinical and prognostic profile of patients with dilated cardiomyopathy caused by mutations in MYBPC3 gene". 2016.
  16. Seabra, Catarina Leal; Nunes, Cláudia; Correia, Marta; Machado, José Carlos; Reis, Celso A.; Gonçalves, Inês; Reis, Salette; Martins, M.C.L.. "Anti-Helicobacter Pylori Activity of Nanoparticles Loaded with a Polyunsaturated Fatty Acid". Trabalho apresentado em 27th European Conference on Biomaterials (ESB 2015), 2015.
    Publicado
  17. Seabra, Catarina Leal; Nunes, Cláudia; Reis, Salette; Correia, Marta; Machado, José Carlos; Reis, Celso A.; Gonçalves, Inês C.; Martins, M.C.L.. "Nanoencapsulation improves the antibactericidal effect of docosahexaenoic acid against Helicobacter pylori". Trabalho apresentado em NanoPT2015- Nanoscience and nanotechnology international conference, Porto, 2015.
    Publicado
  18. Dias, M; Linhas, R; Machado, JC; Cirnes, L; Goncalves, A; Campainha, S; Conde, S; Barroso, A. "KRAS Mutations in Lung Cancer: Prevalence and Outcomes". 2015.
  19. McNicholl, AG; Gasbarrini, A; Tepes, B; Bordin, DS; Lerang, F; Leja, M; Rokkas, T; et al. "PAN-EUROPEAN REGISTRY ON H. PYLORI MANAGEMENT (HP-EUREG): BACTERIAL RESISTANCE". 2015.
  20. McNicholl, AG; Gasbarrini, A; Tepes, B; Bordin, DS; Lerang, F; Leja, M; Rokkas, T; et al. "PAN-EUROPEAN REGISTRY ON H-PYLORI MANAGEMENT (HP-EUREG): FIRST-LINE TREATMENTS AND INTERIM ANALYSIS OF 11 272 PATIENTS". 2015.
  21. Pereira, CM; Veiga, NJ; Amaral, OP; Baptista, M; Resende, C; Cirnes, L; Machado, JC; Bastos, I. "The Influence of Oral Microflora on Oral Health Among a Sample of Portuguese Adolescents.". 2015.
  22. Dias, M; Linhas, R; Machado, JC; Cirnes, L; Goncalves, A; Campainha, S; Conde, S; Barroso, A. "KRAS Mutations: Does It Mean No Erlotinib?". 2015.
  23. McNicholl, AG; Gasbarrini, A; Tepes, B; Bordin, DS; Lerang, F; Leja, M; Rokkas, T; et al. "Pan-European Registry on H. pylori Management (HP-EuReg): Safety". 2015.
  24. McNicholl, AG; Gasbarrini, A; Tepes, B; Bordin, DS; Lerang, F; Leja, M; Rokkas, T; et al. "Pan-European Registry on H. pylori Management (HP-EuReg): Bacterial Resistance". 2015.
  25. McNicholl, AG; Gasbarrini, A; Tepes, B; Bordin, DS; Lerang, F; Leja, M; Rokkas, T; et al. "Pan-European Registry on H. pylori Management (HP-EuReg): Interim Analysis of 8,271 Patients". 2015.
  26. McNicholl, AG; Gasbarrini, A; Tepes, B; Bordin, DS; Lerang, F; Leja, M; Rokkas, T; et al. "Pan-European Registry on H. pylori Management (HP-EuReg): Rescue Treatments". 2015.
  27. Laurent Puigi, P; Costa, JL; Sheils, O; Tops, B; Mafficini, A; Le Corre, D; Kurth, H; et al. "Comprehensive genetic profiling of chromosomal translocations in lung cancer tumors: development and validation of a next-generation sequencing panel in an international multicenter study". 2015.
    10.1158/1538-7445.am2015-4891
  28. Justino, A; Fernandes, G; Barroso, A; Parente, B; Hespanhol, V; Machado, JC; Costa, JL. "Next generation sequencing performance for the detection of mutations in plasma cell free DNA". 2015.
    10.1158/1538-7445.am2015-4930
  29. Neveling, K; Costa, JL; Yntema, H; Pantaleoni, F; Machado, JC; Nelen, M; Tartaglia, M. "Development and Verification of a Noonan Genes Ion AmpliSeq Panel". 2014.
  30. Ferreira, RM; Costa, JL; Machado, JC; Figueiredo, C. "DIFFERENCES IN GASTRIC MICROBIOTA IN GASTRITIS AND GASTRIC CANCER". 2014.
  31. Bernardes, M; Machado, JC; Goncalves, D; Abelha Aleixo, J; Fonseca, R; Madureira, P; Vieira, R; et al. "BSMI AND FOKI VDR GENE POLYMORPHISMS INFLUENCE DISEASE ACTIVITY IN ESTABLISHED RHEUMATOID ARTHRITIS PATIENTS". 2014.
    10.1136/annrheumdis-2014-eular.3913
  32. Bernardes, M; Machado, JC; Vieira, T; Goncalves, D; Vieira, R; Fonseca, R; Madureira, P; et al. "BSMI VDR GENE POLYMORPHISM IS ASSOCIATED WITH BONE MINERAL DENSITY AND BONE METABOLISM IN ESTABLISHED RHEUMATOID ARTHRITIS PATIENTS". 2014.
    10.1136/annrheumdis-2014-eular.3868
  33. Bernardes, M; Madureira, AJ; Martins, MJ; Vieira, T; Goncalves, D; Pereira, JG; Machado, JC; et al. "BONE MINERAL DENSITY, SCLEROSTIN AND INSULIN ARE INDEPENDENTLY ASSOCIATED WITH CORONARY-ARTERY ATHEROSCLEROSIS IN PATIENTS WITH ESTABLISHED RHEUMATOID ARTHRITIS". 2014.
    10.1136/annrheumdis-2014-eular.3921
  34. Magdaleno, SM; Cheng, A; Petraroli, R; Sheils, O; Tops, B; Corre, DL; Kurth, H; et al. "The OncoNetwork Consortium: A global collaborative research study on the development and verification of an Ion AmpliSeq RNA gene lung fusion panel". 2014.
    10.1158/1538-7445.am2014-3575
  35. McNicholl, AG; Gasbarrini, A; Tepes, B; Lerang, F; Bordin, DS; Shvets, O; Rokkas, T; et al. "PAN-EUROPEAN REGISTRY ON H. PYLORI MANAGEMENT (HP-EUREG): SAFETY". 2014.
  36. McNicholl, AG; Gasbarrini, A; Tepes, B; Lerang, F; Bordin, DS; Shvets, O; Rokkas, T; et al. "PAN-EUROPEAN REGISTRY ON H. PYLORI MANAGEMENT (HP-EUREG): RESCUE TREATMENTS". 2014.
  37. McNicholl, AG; Gasbarrini, A; Tepes, B; Lerang, F; Bordin, DS; Shvets, O; Rokkas, T; et al. "PAN-EUROPEAN REGISTRY ON H. PYLORI MANAGEMENT (HP-EUREG): FIRST-LINE TREATMENTS". 2014.
  38. Resende, C; Regalo, G; Duraes, C; Xiaogang, W; Figueiredo, C; Machado, JC. "IL1B SIGNALING LEADS TO INCREASED CELL SURVIVAL OF GASTRIC CARCINOMA CELLS". 2014.
  39. McNicholl, AG; Gasbarrini, A; Tepes, B; Lerang, F; Bordin, DS; Shvets, O; Rokkas, T; et al. "PAN-EUROPEAN REGISTRY ON H. PYLORI MANAGEMENT (HP-EUREG): INTERIM ANALYSIS OF 5792 PATIENTS". 2014.
  40. McNicholl, AG; Tepes, B; Gasbarrini, A; Boyanova, L; Leja, M; Lerang, F; Rokkas, T; et al. "Pan-European Registry on H-pylori Management: Interim Analysis". 2014.
  41. Costa, JL; Justino, A; Barroso, A; Parente, B; Machado, JC. "Detection of somatic alterations in plasma from lung cancer patients". 2014.
    10.1158/1538-7445.am2014-1512
  42. Ferreira, RM; Costa, JL; Figueiredo, C; Machado, JC. "CHARACTERIZATION OF THE GASTRIC MICROBIOTA IN PATIENTS WITH CHRONIC GASTRITIS AND GASTRIC CARCINOMA". 2013.
  43. Bernardes, M; Machado, JC; Vieira, T; Terroso, G; Abelha Aleixo, JAAP; Madureira, P; Vieira, R; et al. "V667M, A1330V AND N740N POLYMORPHISMS IN LRP5 GENE ARE ASSOCIATED WITH BONE MINERAL DENSITY AND BONE METABOLISM IN ESTABLISHED RHEUMATOID ARTHRITIS PATIENTS". 2013.
  44. Ferreira, RM; Pinto Ribeiro, I; Machado, JC; Figueiredo, C. "STRAIN-SPECIFIC SEQUENCES AT THE HELICOBACTER PYLORI CAGA PROMOTER INFLUENCE CAGA EXPRESSION AND INTERLEUKIN-8 SECRETION". 2013.
  45. Rossi, ED; Gerhard, R; Cirnes, L; Machado, JC; Schmitt, FC. "Common and Rare EGFR Mutations. The Challenge of Their Cytological Detection". 2013.
  46. Costa, JL; Gerhard, R; Rossi, ED; Cirnes, L; Justino, A; Machado, JC; Schmitt, F. "Massive Parallel Sequencing To Assess the Mutational Landscape of Fine Needle Aspirate Samples: A Pilot Study". 2013.
  47. Costa, J; Justino, A; Barroso, A; Parente, B; Machado, JC. "Detection of Somatic Alterations in Plasma from Lung Cancer Patients: A Pilot Study". 2013.
  48. Bernardes, M; Vieira, T; Terroso, G; Abelha Aleixo, J; Madureira, P; Vieira, R; Fonseca, R; et al. "RELATIONSHIP BETWEEN BONE MINERAL DENSITY AND RADIOGRAPHIC DAMAGE IN ESTABLISHED RHEUMATOID ARTHRITIS PATIENTS UNDER BIOLOGICS". 2013.
  49. Marcos Pinto, R; Dinis Ribeiro, MJ; Carneiro, F; Machado, JC; Figueiredo, C; Wen, XG; Reis, C; et al. "High-Risk Host Genotype and H. pylori Strains in First Degree Relatives of Patients With Early-Onset Gastric Cancer". 2012.
  50. Ferreira, RM; Machado, JC; Figueiredo, C. "VARIATION IN HELICOBACTER PYLORI CAGA PROMOTER REGION IS ASSOCIATED WITH CAGA EXPRESSION". 2012.
  51. Bernardes, M; Vieira, T; Terroso, G; Aleixo, A; Madureira, P; Vieira, R; Bernardo, A; et al. "DISEASE ACTIVITY IS ASSOCIATED WITH SCLEROSTIN LEVELS AND (HAND AND FEMORAL) BONE MINERAL DENSITY IN PATIENTS WITH ESTABLISHED RHEUMATOID ARTHRITIS". 2012.
    10.1136/annrheumdis-2012-eular.2582
  52. Machado, JC; Correia, M; Michel, V; Heurre, M; Seruca, R; Figueiredo, C; Touati, E. "DOCOSAHEXAENOIC ACID INHIBITS HELICOBACTER PYLORI MICE GASTRIC COLONIZATION". 2011.
  53. Dequeker, E; Bellon, E; Ligtenberg, M; de Hertogh, G; de Stricker, K; Edsjo, A; Laurent Puig, P; et al. "European external quality assessment for the improvement of KRAS testing". 2011.
  54. Costa, AC; Leite, M; Pinto, ML; Ferreira, RM; Costa, AM; Machado, JC; Atherton, JC; Figueiredo, C. "H-pylori disturbs gastric epithelial tight junctions in an inflammation-independent manner". 2010.
  55. Albergaria, A; Ribeiro, AS; Pinho, S; Milanezi, F; Sousa, B; Oliveira, C; Machado, J; et al. "ICI 182,780 induces p-cadherin overexpression in breast cancer cells through chromatin remodelling at the promoter level: role of C/EBPbeta in CDH3 gene activation". 2010.
  56. Lebreiro, A; Martins, E; Almeida, J; Pimenta, S; Bernardes, JM; Machado, JC; Abreu Lima, C. "Utility of molecular diagnosis in a family with Marfan Syndrome and an atypical vascular phenotype.". 2010.
  57. Resende, C; Regalo, G; Seruca, R; Machado, JC. "Determining the CCAAT/enhancer binding protein beta (C/EBP beta) partnership profile in gastric carcinogenesis". 2010.
  58. Gonzalez, E; Cabrera, JA; Machado, JC; Luna, A; Caro, P; Fuertes, B; Pizarro, G; Bayona, S; Sanchez Quintana, D. "Are the consensus screening criteria for a positive 12-lead ECG valid in competitive professional football (soccer) players? A genetic analysis and magnetic resonance imaging correlations". 2010.
  59. Santos, LF; Correia, E; Rodrigues, B; Nunes, L; Costa, A; Henriques, C; Matos, A; et al. "An alternative criterion for Brugada syndrome diagnosis". 2010.
  60. Santos, LF; Faria, R; Moreira, D; Nunes, L; Costa, A; Machado, J; Castedo, S; et al. "Specificity of the provocative test in the Brugada syndrome: the fall of a myth?". 2010.
  61. Gonzalez Caballero, E; Pizarro, G; Fuertes, B; Bayona, S; Machado, JC; Luna, A; Caro, P; Sanchez Quintana, D; Cabrera, JA. "Signs of subclinical myocarditis in a cohort of professional football players: a magnetic resonance imaging and genetic test study". 2010.
  62. Ferreira, AC; Suriano, G; Seruca, R; Machado, JC. "Notch Inhibition Overturns the Apoptosis Resistance Conferred by E-cadherin Deficiency". 2009.
  63. Ferreira, RM; Machado, JC; Carneiro, F; Figueiredo, C. "The Number of H. pylori CagA EPIYA C Tyrosine Phosphorylation Motifs is Associated with Histologic Features of Chronic Gastritis". 2009.
  64. Correia, MM; Michel, V; Oliveira, MJ; Ferreira, R; Figueiredo, C; Seruca, R; Touati, E; Machado, JC. "Omega 3 Docosahexaenoic Acid Inhibits H-pylori Gastric Colonization in C57BL/6 Mice". 2009.
  65. Santos, LF; Faria, R; Correia, E; Rodrigues, B; Nunes, L; Costa, A; Carvalho, JL; et al. "BRUGADA SYNDROME: CAN WE REALLY TRUST ON PROVOCATIVE TEST?". 2009.
  66. Santos, LF; Faria, R; Rodrigues, B; Correia, E; Nunes, L; Costa, A; Carvalho, JL; et al. "POSITIONING OF THE EGC LEADS IN BRUGADA SYNDROME: HIGHER SENSITIVITY WITH LOWER SPECIFICITY? ANSWERS FROM A GENETICALLY CHARACTERIZED FAMILY". 2009.
  67. Ferreira, RM; Machado, JC; Cameiro, F; Figueiredo, C. "The Number of Helicobacter pylori cagA EPIYA C Tyrosine Phosphorylation Motifs Is Associated with Histopathological Features of Chronic Gastritis". 2009.
  68. Peleteiro, B; Carrilho, C; David, L.; Machado, José Carlos; La Vecchia, C.; Lunet, N. "Association between cytokine gene polymorphisms and gastric precancerous lesions". Trabalho apresentado em IEA-EEF European Congress of Epidemiology, Varsóvia, 2009.
    Publicado
  69. Oliveira, MJ; Costa, AM; Costa, AC; Machado, JC; Seruca, R; Mareel, M; Figueiredo, C. "E-cadherin and CagA associate in a multiproteic complex that suppresses H-pylori-mediated cell invasive phenotype". 2008.
  70. Ferreira, AC; Suriano, G; Carneiro, F; Seruca, R; Machado, JC. "E-cadherin loss increases cell survival through a notch-dependent up-regulation of Bcl-2". 2008.
  71. Ferreira, RM; Machado, JC; Carneiro, F; Figueiredo, C. "Helicobacter pylon CagA EPIYA c tyrosine phosphorylation motif influences the risk for gastric carcinoma development". 2008.
  72. Oliveira, MJ; Costa, AM; Costa, AC; Machado, JC; Seruca, R; Mareel, M; Figueiredo, C. "E-cadherin and CagA associate in a tetrameric complex that suppresses Helicobacter pylori-mediated cell invasion". 2008.
  73. Correia, M; Oliveira, MJ; Ferreira, R; Figueiredo, C; Seruca, R; Touati, E; Machado, JC. "DHA from fish and marine oils inhibits H. pylori growth in vitro and in vivo". 2008.
  74. Oliveira, MJ; Costa, AM; Costa, AC; Ferreira, RM; Suriano, G; Machado, JC; Seruca, R; Mareel, M; Figueiredo, C. "The E-cadherin/catenin complex suppresses Helicobacter pylori-mediated cancer cell invasion". 2007.
  75. Canedo, P; Regalo, G; Rocha, J; Machado, JC. "TNFA haplotypes and risk for development of gastric carcinoma". 2007.
  76. Sousa, H; Breda, E; Catarino, R; Pinto, D; Canedo, R; Machado, JC; Medeiros, R. "-308G > A TNF-alpha polymorphism is a genetic susceptibility marker for nasopharyngeal carcinoma development". 2007.
    10.1016/s1359-6349(07)70359-2
  77. Ferreira, RM; Machado, JC; Carneiro, F; Fiqueiredo, C. "Risk for gastric carcinoma development is onfluenced by Helicabocter pylori CagA EPUYA c tyrosine phosphorylation motif". 2007.
  78. Oliveira, MJ; Costa, AM; Costa, AC; Soriano, G; Machado, JC; Seruca, R; Mareel, M; Figueiredo, C. "The E-cadherin/catenin complex suppresses Helicobacter pylori-mediated cancer cell invasion". 2007.
  79. Persson, C; Canedo, P; Machado, J; El Omar, E; Forman, D. "The Polymorphisms of pro-inflammatory genes associated with gastric cancer: A meta-analysis". 2006.
  80. Oliveira, MJ; Costa, AC; Costa, AM; Atherton, JC; Machado, JC; Seruca, R; Mareel, M; Leroy, A; Figueiredo, C. "Helicobacter pylori induces gastric epithelial cell invasion in a c-Met and cag PAI-dependent manner". 2006.
  81. Figueiredo, C; Maximo, V; Soares, P; Machado, JC; Seruca, R; Carneiro, F; Sobrinho Simoes, M. "Mitochondrial DNA (mtDNA) mutations in Helicobacter pylori chronic gastritis and gastric carcinoma". 2006.
  82. Maximo, V; Figueiredo, C; Soares, P; Machado, JC; Carneiro, F; Seruca, R; Sobrinho Simoes, M. "Mitochondrial DNA (MTDNA) mutations in Helicobacter pylori chronic gastritis and gastric carcinoma". 2006.
  83. Canedo, P; Pereira, F; Suriano, G; Figueiredo, C; Carneiro, F; Machado, JC. "The chain 1 interferon gamma receptor (IFNGR1)-56C/T gene polymorphism is associated with increased risk of early gastric carcinoma". 2006.
  84. Soriano, G; Carneiro, F; Oliveira, C; Regateiro, F; Huntsman, DG; Castedo, S; Machado, JC; Seruca, R. "In vitro functional assessment of CDH1 germline missense mutations and implications for clinical management of asymptomatic mutation carriers". 2006.
  85. Mateus, R; Luber, B; Machado, JC; Seruca, R; Suriano, G. "E-cadherin-dependent activation of EGFR is responsible for enhanced cell motility and invasion in gastric cancer". 2006.
  86. Canedo, P; Castanheira Vale, AJ; Lunet, N; Pereira, F; Figueiredo, C; Barros, H; Suriano, G; Carneiro, F; Machado, JC. "Interleukin 8-251T/A polymorphism is associated with risk for gastric carcinoma development in populations of Asian origin but not of Caucasian origin". 2006.
  87. Regale, G; Canedo, P; Soriano, G; Resende, C; Oliveira, MJ; Figueiredo, C; Carneiro, F; Seruca, R; Machado, JC. "C/EBP-beta is over-expressed in gastric carcinoma and is associated with the expression of cyclooxygenase-2". 2006.
  88. Oliveira, MJ; Costa, AC; Henriques, L; Suriano, G; Atherton, J; Machado, JC; Seruca, R; et al. "Helicobacter pylori induces gastric epithelial cell invasion in a cag PAI dependent manner". 2006.
  89. Pereira, F; Magalhães, B; Canedo, P; Peleteiro, B; Lunet, N; Barros, H; Machado, José Carlos. "Pro-inflammatory genetic polymorphisms and the risk of developing colorectal cancer". Trabalho apresentado em 14th United European Gastroenterology Week, Berlim, 2006.
    Publicado
  90. Regalo, G; Canedo, P; Campos, ML; Loncar, MB; Figueiredo, C; Carneiro, F; Machado, JC. "C/EBP-beta is expressed in gastric carcinoma and leads to overexpression of cyclooxygenase-2". 2005.
  91. Oliveira, MJ; Costa, AC; Henriques, L; Thomas, RJ; Atherton, J; Machado, JC; Mareel, M; Leroy, A; Figueiredo, C. "Helicobacter pylori stimulates cancer cell invasion: Molecular mechanisms involved". 2005.
  92. Canedo, P; Gioia Patricola, L; Figueiredo, C; Ferreira, AC; Regalo, G; Carneiro, F; Canzian, F; Machado, JC. "Polymorphisms in inflammation-related genes are associated with increased risk of gastric carcinoma and early development of the disease". 2004.
  93. Machado, JC; Figueiredo, C; Canedo, P; Nabais, S; Alves, CC; Campos, ML; Seruca, R; Carneiro, F; Sobrinho Simoes, M. "A pro-inflammatory genetic profile increases the risk of chronic atrophic gastritis and gastric carcinoma". 2003.
    10.1016/s0016-5085(03)80577-2
  94. Figueiredo, C; Quint, W; Kleter, B; Machado, JC; Van Doorn, LJ. "Helicobacter pylori and interleukin-1 genotyping using a novel reverse hybridization assay". 2003.
    10.1016/s0016-5085(03)81349-5
  95. Machado, JC; Figueiredo, C; Carvalho, R; Canedo, P; Ferreira, AC; Nabais, S; Seruca, R; Carfneiro, F; Sobrinho Simoes, M. "TNFA-308G/A polymorphism is associated with increased risk of gastric carcinoma". 2002.
  96. Figueiredo, C; Machado, JC; van Doorn, LJ; Seruca, R; Carneiro, F; Sobrinho Simoes, M. "Helicobacter pylori vacA and cagA genes, interleukin-1 polymorphisms and histopathological features of gastritis". 2002.
  97. Figueiredo, C; Machado, JC; Seruca, R; Caldas, C; Sousa, S; Carvalho, R; Quint, WG; et al. "Helicobacter pylori virulence and interleukin-1 polymorphisms have a synergistic effect in increasing the risk for chronic atrophic gastritis and gastric carcinoma". 2001.
  98. Oliveira, C; Machado, JC; Carvalho, A; Carneiro, F; Seruca, R; Caldas, C. "E-cadherin germline mutations in families with diffuse gastric cancer". 2001.
  99. Oliveira, C; Machado, JC; Carvalho, R; Cameiro, F; Seruca, R; Caldas, C. "E-cadherin germline mutations in families with diffuse gastric cancer". 2001.
  100. Machado, JC; Sousa, S; Carvalho, R; Oliveira, C; Amorim, A; Seruca, R; Caldas, C; Carneiro, F. "Interleukin-1 gene cluster polymorphisms associated with increased risk of intestinal-type gastric carcinoma.". 2001.
  101. Pinto, M; Oliveira, C; Machado, JC; Cimes, L; Tavares, J; Hamelin, R; Hofstra, R; et al. "MSI-L gastric carcinomas share the hMLH1 methylation status of MSI-H carcinomas but not their clinicopathological profile". 2001.
  102. Nogueira, AMMF; Carneiro, F; Seruca, R; Cirnes, L; Veiga, I; Machado, JC; Sobrinho Simoes, M. "Microsatellite instability and abnormal expression of P53 and ERBB-2 in hyperplastic and adenomatous polyps of the stomach.". 1999.
Tese / Dissertação
  1. Machado, José Carlos Lemos. "Cell differentiation and morphologic heterogeneity of gastric carcinoma : Insights from the immunocytochemical and molecular study of trefoil peptides and E-cadherin = Diferenciação celular e heterogeneidade morfológica do carcinoma gástrico : Estudo imunocitoquímico e molecular de "trefoil peptides" e da caderina-E". Doutoramento, 1999. http://hdl.handle.net/10216/10279.
  2. Machado, José Carlos. "Hormonodependência e carcinoma do estômago. Facto ou ficção? Estudo tecidular, in vitro e em ratinhos atímicos.". Mestrado, Universidade do Porto Faculdade de Medicina, 1994.

Propriedade Intelectual

Patente
  1. Machado, José. 2018. "MICROBIOME MARKERS FOR GASTRIC CANCER".
    Concedida/Emitida
  2. Machado, José. 2011. "DOCOSAHEXANOIC ACID AS INHIBITOR OF H. PYLORI". Estados Unidos.
    Concedida/Emitida

Outros

Empresa spin-off
  1. 2005. Genetest SA. Genetic diagnosis.
Outra produção
  1. ExoBow: A transgenic strategy to study CD63 exosomes in vivo. 2021. Bárbara Adem; Nuno Bastos; Carolina F. Ruivo; Patrícia F. Vieira; Barbara Seidler; José C. Machado; Dieter Saur; Dawen Cai; Sonia A. Melo. https://doi.org/10.1101/2021.03.10.434407.
    10.1101/2021.03.10.434407
  2. The number of Helicobacter pylori CagA EPIYA C tyrosine phosphorylation motifs influences the pattern of gastritis and the development of gastric carcinoma (vol 60, pg 992, 2012). 2016. Ferreira, RM; Machado, JC; Leite, M; Carneiro, F; Figueiredo, C.
    10.1111/his.12918
Atividades

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2022 - Atual Circulating microbial DNA signatures for early diagnosis of gastric cancer
Coorientador
Universidade do Porto Faculdade de Medicina, Portugal
2021 - Atual Microbiome, immune response, and cancer: a game changer triad in colorectal cancer?
Coorientador
Universidade do Porto Faculdade de Medicina, Portugal
2016 - 2024 Unraveling resistance mechanisms and optimizing liquid biopsies for improved lung cancer management
Coorientador
Universidade do Porto Faculdade de Medicina, Portugal
2023 - 2023 Prognostic impact of immune cell recovery following first-line chemotherapy in acute myeloid leukemia
Orientador
 Oncologia (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023 - 2023 Regulatory T cells in Colorectal Cancer immune tolerance
Orientador
 Bioengenharia (Mestrado)
Universidade do Porto Faculdade de Engenharia, Portugal
2017 - 2023 Integrating liquid biopsies into postoperative early-stage lung cancer
Coorientador
Universidade do Porto Faculdade de Medicina, Portugal
2014 - 2023 Avaliação do ctDNA e outros biomarcadores plasmáticos como marcadores de resposta e prognóstico após quimiorradioterapia neoadjuvante no cancro do reto localmente avançado.
Coorientador
Universidade do Porto Faculdade de Medicina, Portugal
2021 - 2021 Intercellular communication in cancer drug resistance : the role of extracellular vesicles
Orientador
 Medicina e Oncologia Molecular (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2019 - 2019 The origin of tumour-infiltrating regulatory T cells
Orientador
 Oncologia (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019 - 2019 The influence of the genetic and immunologic context in the development of colorectal adenoma
Orientador
 Medicina (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2018 - 2018 Role of intra-tumor heterogeneity in cancer immunosurveillance.
Orientador
 Ciências Biomédicas (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018 - 2018 Diagnóstico genético em cardiomiopatias: Uma abordagem multifásica na classificação de variantes genéticas
Orientador
 Medicina e Oncologia Molecular (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2017 - 2017 The role of immune tolerance in tumor escape to immunosurveillance
Orientador
 Bioengenharia (Mestrado)
Universidade do Porto Faculdade de Engenharia, Portugal
2009 - 2015 The role of CREB and C/EBP transcription factors in gastric carcinogenesis
Orientador
 Patologia e Genética Molecular (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2014 - 2014 Genetic heterogeneity in colorectal carcinoma and its clinical implications
Orientador
 Medicina (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2013 - 2013 Caracterização histopalógica e diagnóstico molecular das mutações no gene KRAS em pacientes com carcinoma coloretal metastático: importância para a definição da sensibilidade e especificidade de diferentes técnicas moleculares
Orientador
 Medicina e Oncologia Molecular (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2012 - 2012 "Bone Health in elite ballet dancers: a multidisciplinary approach."
Coorientador
 Ciências do Desporto (Doutoramento)
Universidade do Porto Faculdade de Desporto, Portugal
2008 - 2012 The Role of N-3 Polyunsaturated Fatty Acids in the Modulation of Inflammation and Tumorigenic Process
Orientador
 Biomedicina (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2008 - 2011 Targeting molecular signaling pathways of schistosoma haematobium infection in bladder cancer.
Coorientador
 Biomedicina (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2006 - 2011 Notch signaling pathway in gastric carcinogenesis: E-cadherin inactivation on Noth-dependent cell survival
Orientador
 Biomedicina (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2004 - 2009 From Inflammation to Gastric Cancer: the Role of the C/ebp Transcription Factor Family
Orientador
 Biologia Humana (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2000 - 2009 Genetic Susceptibility to Sporadic Gastric Carcinoma: the Role of Polymorphisms in Inflammation-related Genes
Orientador
 Biologia Humana (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2021 Expression of Thomsen-Friedenreich Antigen in colorectal cancer and association with microsatellite instability
Arguente principal
 Beatriz Farias Leão (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2021 Immune checkpoint inhibitors for the treatment of gastric cancer
Arguente principal
 Soraia Gonçalves Pereira Rodrigues (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2019 The role of CXCR4 in cancer exosomes and metastasis Joana Raquel da Silva Martins (Mestrado)
Universidade do Minho, Portugal
2018 RAD51C germline mutation analysis in families with clinical criteria of Li-Fraumeni syndrome Márcia Filipa Oliveira Cardoso (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018 Glycans as novel immunomodulators in Systemic Lupus Erythematosus. An opportunity for a new therapeutics strategy.
Presidente do júri
 Inês Sofia Moutinho Alves (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2018 Disclosing the role of helicobacter pylori outer membrane vesicles in bacterial pathogenesis
Arguente
 Joana Teixeira Pinto de Melo (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017 Germline and Somatic ALK Alterations in Neuroblastoma Patients Ana Catarina Marinho da Rocha (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2015 ANALYSIS OF OUTCOME AND CANCER STEM CELLS STATUS IN PATIENTS WITH RESECTABLE PANCREATIC ADENOCARCINOMA Daniela Dias Santos (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2015 Molecular-based approaches to characterize the microbiome: Exploring the gastric cancer scenario Joana Pereira Marques (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2015 Gastric Cancer Morphological, Immunophenotypic and molecular heterogeneity Irene Gullo (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2015 Unravelling Helicobacter pylori strategies to disrupt cell-cell junctions Miguel Sardinha Marques (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2015 Pole Somatic Mutations in Advanced Colorectal Cancer Joana Sofia Gonçalves Guerra (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2014 Tim-3 expression and function in Natural Killaer (NK) cells in metastatic melanoma Inês Esteves Domingues Pires da Silva (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2014 Novel insights in IBD pathogenesis: T cell receptor N-glycosylation as a new molecular mechanism Ana Isabel Mendes Dias (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2014 Mutational analysis of KRAS and NRAS in metastatic colorectal cancer Romina Oliveira Silva (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2014 Detection of fusion genes and novel RNA variants in cancer
Arguente
 MARTHE LØVF (Doutoramento)
Universitetet i Oslo Det Matematisk-naturvitenskapelige Fakultet, Noruega
2013 The Role of HOXB13 Gene in Colorectal Cancer Miguel Gomes Silva (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2013 A Model of BMP Pathway overexpression in the Gastrointestinal Tract - an in vivo Approach Ana Luísa Pinto Amaral (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2013 Generation of a stepwise prostate carcinogenesis model – A study of epithelial to mesenchymal transition and malignant transformation of prostate primary epithelial cells
Arguente
 Yi Qu (Doutoramento)
Universitetet i Bergen Det medisinsk-odontologiske fakultet, Noruega

Universitetet i Bergen Gades Institutt, Noruega
2011 Clinical and functional relevance of Helicobacter pylori vacA intermediate region and CagA tyrosine phosphorylation motifs. Rui Manuel Mendes da Silva Ferreira (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2010 Hereditary predisposition to prostate cancer Sofia de Melo Feiteira Maia (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2010 Towards the development of detection methods for helicobacter pylori within the human body
Arguente principal
 Silvia Marisa Janeiro Fontenete (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2009 Helicobacter pylori dans un modèle de carcinogenèse gastrique impliquant les cellules souches mésenchymateuses
Arguente
 Jonathan Ferrand (Doutoramento)
Université de Bordeaux École Doctorale des Sciences de la Vie et de la Santé, França
2009 Influência de Polimorfismos Genéticos e da Biologia Tumoral no Comportamento do Cancro do Pulmão
Vogal
 Maria Gabriela de Oliveira Fernandes (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2008 Distribuição Geográfica e Patologias Associadas À Metilação do Dna Genómico em Helicobacter Pylori Ana Filipa Ferreira do Vale (Doutoramento)
Universidade Católica Portuguesa, Portugal
2005 Estudo de Alterações Genéticas Envolvidas na Via Carcinogénese do Cancro do Cólon e Recto Associado À Colite Ulcerosa Lara Cristina dos Santos Maia Sayanda (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2019/08/01 - Atual Microbiota in Health and Disease (2704-8845)
2008 - Atual Helicobacter (1523-5378) Wiley (Blackwell Publishing)
2009 - 2011 Gut Pathogens (1757-4749) Springer (Biomed Central Ltd.)

Membro de associação

Nome da associação Tipo de participação
2014 - Atual European Society of Human Genetics Member
2013 - Atual European Society of Clinical Microbiology and Infectious Diseases Member
2006 - Atual European Helicobacter Study Group Active member
2004 - Atual American Association for Cancer Research Active member
1999 - Atual Sociedade Portuguesa de Genética Humana Member
1993 - Atual European Association for Cancer Research Member
1990 - Atual Ordem dos Biólogos
2009 - 2010 European Helicobacter Study Group President
2003 - 2010 European Cancer Prevention Organization

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2015 - Atual Data and Safety Monitoring Board (DSMB)” for the study “Multicentric randomized study of H. pylori eradication and pepsinogen testing for prevention of gastric cancer mortality: the GISTAR study
Membro
2014 - Atual Scientific Council - Medical Faculty of Porto
Membro
 Universidade do Porto Faculdade de Medicina, Portugal
2013 - 2017 Scientific Committee ESHG
Membro
 European Society of Human Genetics, Áustria
2011 - 2015 Scientific Committee UEG
Membro
 United European Gastroenterology, Áustria
Distinções

Prémio

2018 PFIZER 2018 Award - Clinical research
Sociedade de Ciências Médicas de Lisboa, Portugal
2005 National Prize of Gastroenterology
2004 National Prize of Gastroenterology
2003 1st Prize LabMed
2002 1st Prize LabMed
2000 ECP Young Researcher Prize

Outra distinção

2001 Scholar-in-training Award for Promising Cancer Research