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Cláudio M. Gomes (PhD 1999, h-index 39) is Full Professor of Biochemistry at Ciências ULisboa and an expert in protein biochemistry, structure and folding, leading research on molecular mechanisms underlying neurodegenerative and protein folding diseases. ¦ Prof. Gomes obtained a PhD in Biochemistry (1999) from ITQB/NOVA through the competitive Gulbenkian PhD Program (1995-1998) and holds a BSc in Applied Chemistry/Biotechnology (1994) from FCT/NOVA. His academic career launched as Assistant Professor at FCT/NOVA (2000), then transitioned to ITQB/NOVA (2003) as an independent group leader after a competitive appointment as Assistant Researcher (held 2003-2014), earning the title of Aggregate in Structural Biochemistry (2013). ¦ In 2015, he secured a top-level Coordinating Researcher position through the FCT Investigator Programme and moved his laboratory to BioISI Ciências ULisboa, subsequently becoming Associate Professor (2016) and Full Professor (2023) through competitive appointments. ¦ As senior academic Prof. Gomes has held several positions of responsibility at Ciências ULisboa including Vice-President of the Chemistry and Biochemistry Department (2018-20), elected member of the Pedagogical Council (2019-2021), Coordinator of the MSc Biochemistry and Biomedicine (2018-2024), and Vice-coordinator of the BioISI Biomedicine thematic line (2018-). ¦ Prof. Gomes heads the Protein Misfolding and Amyloids in Biomedicine laboratory at BioISI Ciências ULisboa (https://folding.campus.ciencias.ulisboa.pt/). The laboratory focuses on unraveling the molecular mechanisms of protein misfolding and aggregation, with specific emphasis on neurodegenerative and protein folding diseases. Using a collaborative and integrative approach, the research spans from molecular levels to cellular and organismal contexts, employing a combination of biochemical, molecular, cellular, and biophysical methods. ¦ Coordinator of TWIN2PIPSA Horizon Europe Twinning project (2022-25) fostering collaboration with the Universities of Cambridge, Copenhagen, and Tel Aviv. Prof. Gomes has secured research funding amounting to 2M€ from national and international sources. As coordinator, he led 16 national and 4 international grants, contributing significantly to the advancement of diverse research areas. ¦ Prof Gomes has consistently demonstrated a profound commitment to nurturing researchers and fostering collaborative research environments. Overseeing the academic journeys of 60 students, including 12 PhDs and 21 MSc graduates, he ensured their success, with recognized works receiving awards for excellence. The impact of his mentorship extends to 10 post-docs, 1 Assistant Researcher, and 1 Project Manager as well as to 11 BSc thesis students and 12 international trainees, contributing to a diverse and dynamic research community. ¦ He regularly serves as international expert project reviewer for national funding agencies, the European Commission and foundations and as peer-reviewer for international scientific journals. ¦ Prof. Gomes has extensive publishing and editorial experience, both as a prolific author (134 international peer reviewed papers), member of editorial boards and editor of thematic issues and books. His work has received +4400 citations and his current h-index is 38 (WoS/Scopus).
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Identificação

Identificação pessoal

Nome completo
Cláudio Emanuel Moreira Gomes

Nomes de citação

  • Cláudio M. Gomes

Identificadores de autor

Ciência ID
A71E-B925-C139
ORCID iD
0000-0003-4662-6933

Endereços de correio eletrónico

  • cmgomes@fc.ul.pt (Profissional)

Moradas

  • BioISI - Faculdade de Ciências da Universidade de Lisboa. FCUL Edifício C8, Campo Grande 1749-016 Lisboa, 1749-016, Lisboa, Lisboa, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Bioquímica
  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências
  • Ciências Naturais - Ciências Biológicas - Biologia Molecular
  • Ciências Naturais - Ciências Biológicas - Biofísica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Formação
Grau Classificação
2013/09/19
Concluído
 Biochemistry (specialty Structural Biochemistry) (Título de Agregado)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
"n/a" (TESE/DISSERTAÇÃO)
 Aprovado / Approved
1999
Concluído
 PhD in Biochemistry - Gulbenkian Programme in Biology and Medicine (2nd Edition) (Doutoramento)
Especialização em Bioquímica
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
"Oxygen utilisation by prokaryotes - Redox proteins from archaea and anaerobic bacteria" (TESE/DISSERTAÇÃO)
 Aprovado / Approved
1995
Concluído
 BSc Applied Chemistry / Biotechnology (5 years course) (Licenciatura)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"n/a" (TESE/DISSERTAÇÃO)
 Aprovado / Approved
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2015/01/01 - 2016/08/31 Investigador Coordenador (carreira) (Investigação) Universidade de Lisboa Faculdade de Ciências, Portugal
2003/12/01 - 2014/12/31 Investigador Auxiliar (carreira) (Investigação) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
1999/07/01 - 2003/11/01 Investigador (Investigação) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2023/06/01 - Atual Professor Catedrático (Docente Universitário) Universidade de Lisboa Faculdade de Ciências, Portugal
Universidade de Lisboa Faculdade de Ciências, Portugal
2016/09/01 - 2023/05/31 Professor Associado (Docente Universitário) Universidade de Lisboa Faculdade de Ciências, Portugal
2000/03/01 - 2003/11/01 Professor Auxiliar Convidado (Docente Universitário) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2000/09/01 - 2001/07/01 Professor Auxiliar Convidado (Docente Universitário) Universidade Católica Portuguesa Campus Sintra, Portugal

Cargos e Funções

Categoria Profissional
Instituição de acolhimento 		Empregador
2021 - Atual Member of the 'Neurodegenerative Diseases' Workgroup RedeSAÚDE ULisboa Universidade de Lisboa Faculdade de Ciências, Portugal
Universidade de Lisboa, Portugal
2018/09/01 - Atual Vice-coordinator of the BioISI Biomedicine Thematic Line Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
2018/03/01 - Atual Coordinator of the Master's in Biochemistry and Biomedicine Universidade de Lisboa Faculdade de Ciências, Portugal
2018 - Atual BioISI Executive Board member Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
2019 - 2022/03 Member of the Pedagogical Council (Elected Representative) Universidade de Lisboa Faculdade de Ciências, Portugal
Universidade de Lisboa Faculdade de Ciências, Portugal
(...)
2018/03/01 - 2020/06 Vice President of the Chemistry and Biochemistry Department Universidade de Lisboa Faculdade de Ciências, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2015/01/01 - Atual Coordinator of the Protein Misfolding and Amyloids in Biomedicine Laboratory Universidade de Lisboa Faculdade de Ciências, Portugal
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
2015/10/01 - 2016 Visiting Professor University of Belgrade Faculty of Medicine, Sérvia
1995/09/01 - 1998/12/01 Ph.D. Student (Gulbenkian PhD programme in Biology and Medicine) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
1994/09/01 - 1995/08/01 Post Graduation student of the Gulbenkian PhD programme in Biology and Medicine Instituto Gulbenkian de Ciência, Portugal
Instituto Gulbenkian de Ciência, Portugal
Projetos

Projeto

Designação Financiadores
2021/12 - Atual How does the human brain regulate protein aggregation in Alzheimer's disease?
LCAWARD21
Investigador responsável
FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal

Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal
AgileBio SARL
Em curso
2022/10/01 - 2025/09/30 Twinning for Excellence in Biophysics of Protein Interactions & Self-Assembly (TWIN2PIPSA)
101079147
Investigador responsável
FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal

University of Cambridge Department of Chemistry, Reino Unido

Tel Aviv University, Israel

Københavns Universitet Biologisk Institut, Dinamarca
European Commission

Research Executive Agency
Em curso
2019/03/01 - 2023/02/28 Mechanisms of Protein Dysfunction in mitochondrial disease
PTDC/BIA-BQM/29963/2017
Co-Investigador Responsável (Co-IR)
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2016/05/02 - 2019/12/31 Regulation of mitochondrial beta oxidation by non-enzymatic post-translational modifications in health and disease
PTDC/BBB-BQB/5366/2014
Co-Investigador Responsável (Co-IR)
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2015/04 - 2019/12 Proteotoxic insults and synaptic dysfunction in the ageing brain
343/14
Investigador responsável
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
 Fundação Bial
Concluído
2016/06/01 - 2019/11/30 MIMED - Mining the Molecular Metric Space for Drug Design
PTDC/EEI-ESS/4923/2014
Investigador
Universidade de Lisboa Laboratório de Sistemas Informáticos de Grande Escala, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2016/01 - 2019/01 The calcium binding S100B protein as a modulator of amyloid beta aggregation and a potential therapeutic target in Alzheimer's disease
grant.Provided by PTCRIS: 140764
PTDC/NEU-NMC/2138/2014
Investigador responsável
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2016/01 - 2016/12 Atomic Force Microscopy approaches to study protein self-assemblies and interactions
BioISI-InternalGrants-2016
Investigador responsável
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
 Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas

Fundação para a Ciência e a Tecnologia, I.P.
Concluído
2015/01/01 - 2016/08/31 Molecular mechanisms in brain proteinopathies: pro-inflammatory S100 proteins as modulators of amyloid pathogenic cascades in Alzheimer's Disease
IF/01046/2014/CP1216/CT0015
Investigador responsável
Universidade de Lisboa Faculdade de Ciências, Portugal

Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2012/02/01 - 2015/07/31 Mechanisms of SOD1 toxic aggregation in neurodegenerative processes
PTDC/QUI-BIQ/117789/2010
Provided by PTCRIS: 117789
Investigador responsável
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
 Fundação para a Ciência e a Tecnologia

Fundação para a Ciência e a Tecnologia, I.P.
Concluído
2012/02 - 2015/07 Recovery of misfolded and aggregated proteins using biological nanoreactors and small molecules
Provided by PTCRIS: 117793
PTDC/EBB-BIO/117793/2010
Investigador responsável
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.

Fundação para a Ciência e a Tecnologia
Concluído
2012/03 - 2015/06 Characterization of ER-quality control for the F508del-CFTR protein: potential therapeutic targets for cystic fibrosis
Provided by PTCRIS: 122299
PTDC/SAU-GMG/122299/2010
Investigador
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Fundação para a Ciência e a Tecnologia, I.P.

Fundação para a Ciência e a Tecnologia
Concluído
2008/01 - 2011/12 Towards the understanding of the energetic and structural interplay between metal sites and protein folding
Provided by PTCRIS: 70101
PTDC/QUI/70101/2006
Investigador responsável
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.

Fundação para a Ciência e a Tecnologia
Concluído
2007/07 - 2011/06 Functional analysis and origins of the pathophysiology of mutations within genes of the fatty acid oxidation pathway: implications in the multiple acyl-CoA dehydrogenase deficiency disorder
Provided by PTCRIS: 70033
PTDC/SAU-GMG/70033/2006
Investigador responsável
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.

Fundação para a Ciência e a Tecnologia
Concluído
2005/07/01 - 2007/06/30 Screening hyperthermophilic Proteomes for Hyperstable Proteins
POCI/BIO/58465/2004
Investigador responsável
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
1996/10/01 - 1998/12/31 Metalloproteins from the respiratory chain of extremophilic archaeon
PRAXIS XXI/BD/9793/96
Investigador responsável
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído

Outro

Designação Financiadores
2018/01 - 2018/12 Single molecule approaches to study S100B protein interactions with Aß amyloid fibrils
BioISI-InternalGrants-2018
Investigador responsável
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal

Fundação para a Ciência e a Tecnologia, Portugal
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas
Concluído
Produções

Publicações

Artigo em revista
  1. Romina Coelho; Chiara A. De Benedictis; Ann Katrin Sauer; António J. Figueira; Hélio Faustino; Andreas M. Grabrucker; Cláudio M. Gomes. "Secondary Modification of S100B Influences Anti Amyloid-ß Aggregation Activity and Alzheimer¿s Disease Pathology". International Journal of Molecular Sciences (2024): https://doi.org/10.3390/ijms25031787.
    10.3390/ijms25031787
  2. Ivone M. Martins; Alexandre Lima; Wim de Graaff; Joana S. Cristóvão; Niek Brosens; Eleonora Aronica; Leon D. Kluskens; et al. "M13 phage grafted with peptide motifs as a tool to detect amyloid-ß oligomers in brain tissue". Communications Biology (2024): https://doi.org/10.1038/s42003-024-05806-5.
    10.1038/s42003-024-05806-5
  3. António J. Figueira; Saavedra, Joana; Cardoso, Isabel; Cláudio M. Gomes. Autor correspondente: Cláudio M. Gomes. "S100B chaperone multimers suppress the formation of oligomers during Aß42 aggregation". Frontiers in Neuroscience 17 (2023): http://dx.doi.org/10.3389/fnins.2023.1162741.
    Acesso aberto • Publicado • 10.3389/fnins.2023.1162741
  4. Guilherme G. Moreira; Cláudio M. Gomes. "Tau liquid-liquid phase separation is modulated by the Ca-switched chaperone activity of the S100B protein". Journal of Neurochemistry (2023): http://dx.doi.org/10.1111/jnc.15756.
    Publicado • 10.1111/jnc.15756
  5. Vázquez-Lorente, Héctor; Dunderovic, Duško M.; Tatic, Svetislav B.; Radojevic-Škodric, Sanja; Cláudio M. Gomes; Paunovic, Ivan R.; Dragutinovic, Vesna. Autor correspondente: Dragutinovic, Vesna. "Matrix Metalloproteinases 2 and 9 and Their Tissue Inhibitors in the Diagnostics of Medullary Thyroid Carcinoma". Applied Immunohistochemistry & Molecular Morphology 31 2 (2022): 121-127. http://dx.doi.org/10.1097/pai.0000000000001092.
    10.1097/pai.0000000000001092
  6. Figueira, António J.; Moreira, Guilherme G.; Saavedra, Joana; Cardoso, Isabel; Gomes, Cláudio M.. "Tetramerization of the S100B Chaperone Spawns a Ca2+ Independent Regulatory Surface that Enhances Anti-aggregation Activity and Client Specificity". Journal of Molecular Biology 434 19 (2022): 167791. http://dx.doi.org/10.1016/j.jmb.2022.167791.
    Publicado • 10.1016/j.jmb.2022.167791
  7. Vázquez-Lorente, Héctor; Dundjerovic, Duško M.; Tatic, Svetislav B.; Rodríguez-Menéndez, Sara; González-Iglesias, Héctor; Gomes, Cláudio M.; Paunovic, Ivan R.; Dragutinovic, Vesna V.. "Relationship between Trace Elements and Matrix Metalloproteinases 2 and 9 and their Tissue Inhibitors in Medullary Thyroid Carcinoma". Biological Trace Element Research (2022): http://dx.doi.org/10.1007/s12011-022-03431-z.
    Publicado • 10.1007/s12011-022-03431-z
  8. Bhatt, Dhaval P.; Mills, C. Allie; Anderson, Kristin A.; Henriques, Bárbara J.; Lucas, Tânia G.; Francisco, Sara; Liu, Juan; et al. "Deglutarylation of glutaryl-CoA dehydrogenase by deacylating enzyme SIRT5 promotes lysine oxidation in mice". Journal of Biological Chemistry 298 4 (2022): 101723. http://dx.doi.org/10.1016/j.jbc.2022.101723.
    10.1016/j.jbc.2022.101723
  9. Ammendola, Serena; Secli, Valerio; Pacello, Francesca; Mastropasqua, Maria Chiara; Romão, Mariana A; Gomes, Cláudio M; Battistoni, Andrea. "Zinc-binding metallophores protect Pseudomonas aeruginosa from calprotectin-mediated metal starvation". FEMS Microbiology Letters 369 1 (2022): http://dx.doi.org/10.1093/femsle/fnac071.
    Publicado • 10.1093/femsle/fnac071
  10. Eleonora Daini; Simone Hagmeyer; Chiara A. De Benedictis; Joana S. Cristóvão; Martina Bodria; Aisling M. Ross; Andrea Raab; et al. "S100B dysregulation during brain development affects synaptic SHANK protein networks via alteration of zinc homeostasis". Translational Psychiatry (2021): https://doi.org/10.1038/s41398-021-01694-z.
    10.1038/s41398-021-01694-z
  11. Moreira, Guilherme G.; Cantrelle, François-Xavier; Quezada, Andrea; Carvalho, Filipa S.; Cristóvão, Joana S.; Sengupta, Urmi; Puangmalai, Nicha; et al. Autor correspondente: Gomes, Cláudio M.. "Dynamic interactions and Ca2+-binding modulate the holdase-type chaperone activity of S100B preventing tau aggregation and seeding". Nature Communications 12 1 (2021): http://dx.doi.org/10.1038/s41467-021-26584-2.
    10.1038/s41467-021-26584-2
  12. Loera-Valencia, Raúl; Ismail, Muhammad-Al-Mustafa; Goikolea, Julen; Lodeiro, Maria; Mateos, Laura; Björkhem, Ingemar; Puerta, Elena; et al. "Hypercholesterolemia and 27-Hydroxycholesterol Increase S100A8 and RAGE Expression in the Brain: a Link Between Cholesterol, Alarmins, and Neurodegeneration". Molecular Neurobiology 58 12 (2021): 6063-6076. http://dx.doi.org/10.1007/s12035-021-02521-8.
    Acesso aberto • Publicado • 10.1007/s12035-021-02521-8
  13. Bárbara J. Henriques; Rikke Katrine Jentoft Olsen; Cláudio M. Gomes; Peter Bross. "Electron transfer flavoprotein and its role in mitochondrial energy metabolism in health and disease". Gene 776 (2021): 145407-145407. https://doi.org/10.1016/j.gene.2021.145407.
    10.1016/j.gene.2021.145407
  14. Filipe E. P. Rodrigues; António J. Figueira; Cláudio M. Gomes; Miguel Machuqueiro. "Computational Analysis of the Interactions between the S100B Extracellular Chaperone and Its Amyloid ß Peptide Client". International Journal of Molecular Sciences 22 7 (2021): 3629-3629. https://doi.org/10.3390/ijms22073629.
    10.3390/ijms22073629
  15. Joana S. Cristóvão; Mariana A. Romão; Rodrigo Gallardo; Joost Schymkowitz; Frederic Rousseau; Cláudio M. Gomes. "Targeting S100B with Peptides Encoding Intrinsic Aggregation-Prone Sequence Segments". Molecules 26 2 (2021): 440-440. https://doi.org/10.3390/molecules26020440.
    10.3390/molecules26020440
  16. Joana S. Cristóvão; Guilherme G. Moreira; Filipe E. P. Rodrigues; Ana P. Carapeto; Mário S. Rodrigues; Isabel Cardoso; António E. N. Ferreira; et al. "Cu2+-binding to S100B triggers polymerization of disulfide cross-linked tetramers with enhanced chaperone activity against amyloid-ß aggregation". Chemical Communications 57 3 (2021): 379-382. https://doi.org/10.1039/D0CC06842J.
    10.1039/D0CC06842J
  17. Ribeiro, Sara S.; Castro, Tarsila G.; Gomes, Cláudio M.; Marcos, João C.. "Hofmeister effects on protein stability are dependent on the nature of the unfolded state". Physical Chemistry Chemical Physics 23 44 (2021): 25210-25225. http://dx.doi.org/10.1039/d1cp02477a.
    10.1039/d1cp02477a
  18. Martins, Pedro M.; Navarro, Susanna; Silva, Alexandra; Pinto, Maria F.; Sárkány, Zsuzsa; Figueiredo, Francisco; Pereira, Pedro José Barbosa; et al. "MIRRAGGE – Minimum Information Required for Reproducible AGGregation Experiments". Frontiers in Molecular Neuroscience 13 (2020): http://dx.doi.org/10.3389/fnmol.2020.582488.
    10.3389/fnmol.2020.582488
  19. Ana M. de Matos; M. Teresa Blázquez-Sánchez; Andreia Bento-Oliveira; Rodrigo F. M. de Almeida; Rafael Nunes; Pedro E. M. Lopes; Miguel Machuqueiro; et al. "Glucosylpolyphenols as Inhibitors of Aß-Induced Fyn Kinase Activation and Tau Phosphorylation: Synthesis, Membrane Permeability, and Exploratory Target Assessment within the Scope of Type 2 Diabetes and Alzheimer's Disease". Journal of Medicinal Chemistry (2020): https://doi.org/10.1021/acs.jmedchem.0c00841.
    10.1021/acs.jmedchem.0c00841
  20. Joana V. Ribeiro; Cláudio M. Gomes; Henriques, Bárbara J. Autor correspondente: Henriques, Bárbara J. "Functional Recovery of a GCDH Variant Associated to Severe Deflavinylation - Molecular Insights into Potential Beneficial Effects of Riboflavin Supplementation in Glutaric Aciduria-Type I Patients". International Journal of Molecular Sciences 21 19 (2020): 7063. http://dx.doi.org/10.3390/ijms21197063.
    Publicado • 10.3390/ijms21197063
  21. Joana S. Cristóvão; António J. Figueira; Ana P. Carapeto; Mário S. Rodrigues; Isabel Cardoso; Cláudio M. Gomes. "The S100B Alarmin Is a Dual-Function Chaperone Suppressing Amyloid-ß Oligomerization through Combined Zinc Chelation and Inhibition of Protein Aggregation". ACS Chemical Neuroscience (2020): https://doi.org/10.1021/acschemneuro.0c00392.
    10.1021/acschemneuro.0c00392
  22. Lucas, T.G.; Henriques, B.J.; Gomes, C.M.. "Conformational analysis of the riboflavin-responsive ETF:QO-p.Pro456Leu variant associated with mild multiple acyl-CoA dehydrogenase deficiency". Biochimica et Biophysica Acta - Proteins and Proteomics 1868 6 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85080144241&partnerID=MN8TOARS.
    10.1016/j.bbapap.2020.140393
  23. Henriques, B.J.; Lucas, T.G.; Martins, E.; Gaspar, A.; Bandeira, A.; Nogueira, C.; Brandão, O.; et al. "Molecular and Clinical Investigations on Portuguese Patients with Multiple acyl-CoA Dehydrogenase Deficiency". Current molecular medicine 19 7 (2019): 487-493. http://www.scopus.com/inward/record.url?eid=2-s2.0-85071568818&partnerID=MN8TOARS.
    10.2174/1566524019666190507114748
  24. Hagmeyer, S.; Romão, M.A.; Cristóvão, J.S.; Vilella, A.; Zoli, M.; Gomes, C.M.; Grabrucker, A.M.. "Distribution and relative abundance of S100 proteins in the brain of the APP23 Alzheimer's disease model mice". Frontiers in Neuroscience 13 JUN (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85068474639&partnerID=MN8TOARS.
    10.3389/fnins.2019.00640
  25. Reis, F.P.; Bárria, C.; Gomez-Puertas, P.; Gomes, C.M.; Arraiano, C.M.. "Identification of temperature-sensitive mutations and characterization of thermolabile RNase II variants". FEBS Letters 593 3 (2019): 352-360. http://www.scopus.com/inward/record.url?eid=2-s2.0-85059154882&partnerID=MN8TOARS.
    10.1002/1873-3468.13313
  26. Ribeiro, J.V.; Lucas, T.G.; Bross, P.; Gomes, C.M.; Henriques, B.J.. "Potential complementation effects of two disease-associated mutations in tetrameric glutaryl-CoA dehydrogenase is due to inter subunit stability-activity counterbalance". Biochimica et Biophysica Acta - Proteins and Proteomics (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85072215716&partnerID=MN8TOARS.
    10.1016/j.bbapap.2019.140269
  27. Cristóvaõ, J.S.; Gomes, C.M.. "S100 Proteins in Alzheimer's Disease". Frontiers in Neuroscience 13 MAY (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85068445169&partnerID=MN8TOARS.
    10.3389/fnins.2019.00463
  28. Moreira, G.G.; Cristóvão, J.S.; Torres, V.M.; Carapeto, A.P.; Rodrigues, M.S.; Landrieu, I.; Cordeiro, C.; Gomes, C.M.. "Zinc binding to tau influences aggregation kinetics and oligomer distribution". International Journal of Molecular Sciences 20 23 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85075774527&partnerID=MN8TOARS.
    10.3390/ijms20235979
  29. Joana S. Cristóvão; Vanessa K. Morris; Isabel Cardoso; Sónia S. Leal; Javier Martínez; Hugo M. Botelho; Christoph Göbl; et al. "The neuronal S100B protein is a calcium-tuned suppressor of amyloid-ß aggregation". Science Advances 4 6 (2018): eaaq1702-eaaq1702. https://doi.org/10.1126%2Fsciadv.aaq1702.
    10.1126/sciadv.aaq1702
  30. Joana F. Ferreira; Cláudio M. Gomes; Bárbara J. Henriques; Cláudio M. Gomes; Henriques, Bárbara J. "Implication of post-translational modifications on ETF, a structural and functional approach". Free Radical Biology and Medicine 120 (2018): S144-S144. https://doi.org/10.1016%2Fj.freeradbiomed.2018.04.475.
    Publicado • 10.1016/j.freeradbiomed.2018.04.475
  31. Santos, G.; Barateiro, A.; Gomes, C.M.; Brites, D.; Fernandes, A.. "Impaired oligodendrogenesis and myelination by elevated S100B levels during neurodevelopment". Neuropharmacology 129 (2018): 69-83. http://www.scopus.com/inward/record.url?eid=2-s2.0-85034070602&partnerID=MN8TOARS.
    10.1016/j.neuropharm.2017.11.002
  32. Hagmeyer, S.; Cristóvão, J.S.; Mulvihill, J.J.E.; Boeckers, T.M.; Gomes, C.M.; Grabrucker, A.M.. "Zinc binding to S100B affords regulation of trace metal homeostasis and excitotoxicity in the brain". Frontiers in Molecular Neuroscience 10 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85041301032&partnerID=MN8TOARS.
    10.3389/fnmol.2017.00456
  33. Matos, A.M.; Cristóvaõ, J.S.; Yashunsky, D.V.; Nifantiev, N.E.; Viana, A.S.; Gomes, C.M.; Rauter, A.P.. "Synthesis and effects of flavonoid structure variation on amyloid-ß aggregation". Pure and Applied Chemistry 89 9 (2017): 1305-1320. http://www.scopus.com/inward/record.url?eid=2-s2.0-85028518254&partnerID=MN8TOARS.
    10.1515/pac-2017-0201
  34. Gouveia, Z.; Carlos, A.R.; Yuan, X.; Aires-da-Silva, F.; Stocker, R.; Maghzal, G.J.; Leal, S.S.; et al. "Characterization of plasma labile heme in hemolytic conditions". FEBS Journal 284 19 (2017): 3278-3301. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029000547&partnerID=MN8TOARS.
    10.1111/febs.14192
  35. Cristóvão, J.S.; Santos, R.; Gomes, C.M.. "Metals and Neuronal Metal Binding Proteins Implicated in Alzheimer's Disease". Oxidative Medicine and Cellular Longevity 2016 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84962853153&partnerID=MN8TOARS.
    10.1155/2016/9812178
  36. Adam, P.; Krížková, S.; Heger, Z.; Babula, P.; Pekarík, V.; Vaculovicová, M.; Gomes, C.M.; Kizek, R.; Adam, V.. "Metallothioneins in Prion-and Amyloid-Related Diseases". Journal of Alzheimer's Disease 51 3 (2016): 637-656. http://www.scopus.com/inward/record.url?eid=2-s2.0-84963757777&partnerID=MN8TOARS.
    10.3233/JAD-150984
  37. Henriques, B.J.; Lucas, T.G.; Gomes, C.M.. "Therapeutic approaches using riboflavin in mitochondrial energy metabolism disorders". Current Drug Targets 17 13 (2016): 1527-1534. http://www.scopus.com/inward/record.url?eid=2-s2.0-84991227435&partnerID=MN8TOARS.
    10.2174/1389450117666160813180812
  38. Vieira, M.; Leal, S.S.; Gomes, C.M.; Saraiva, M.J.. "Evidence for synergistic action of transthyretin and IGF-I over the IGF-I receptor". Biochimica et Biophysica Acta - Molecular Basis of Disease 1862 4 (2016): 797-804. http://www.scopus.com/inward/record.url?eid=2-s2.0-84958526939&partnerID=MN8TOARS.
    10.1016/j.bbadis.2016.01.008
  39. Gomes, Cláudio. "Free superoxide is an intermediate in the production of H2O2 by copper(I)-Aß peptide and O2". Angewandte Chemie - International Edition 55 3 (2016): 1085-1089. http://www.scopus.com/inward/record.url?eid=2-s2.0-84954243090&partnerID=MN8TOARS.
    10.1002/anie.201508597
  40. Leal, S.S.; Cristóvão, J.S.; Biesemeier, A.; Cardoso, I.; Gomes, C.M.. "Aberrant zinc binding to immature conformers of metal-free copper-zinc superoxide dismutase triggers amorphous aggregation". Metallomics 7 2 (2015): 333-346. http://www.scopus.com/inward/record.url?eid=2-s2.0-84923081496&partnerID=MN8TOARS.
    10.1039/c4mt00278d
  41. Estácio, S.G.; Leal, S.S.; Cristóvão, J.S.; Faísca, P.F.N.; Gomes, C.M.. "Calcium binding to gatekeeper residues flanking aggregation-prone segments underlies non-fibrillar amyloid traits in superoxide dismutase 1 (SOD1)". Biochimica et Biophysica Acta - Proteins and Proteomics 1854 2 (2015): 118-126. http://www.scopus.com/inward/record.url?eid=2-s2.0-84915749799&partnerID=MN8TOARS.
    10.1016/j.bbapap.2014.11.005
  42. Deive, F.J.; Ruivo, D.; Rodrigues, J.V.; Gomes, C.M.; Sanromán, M.A.; Rebelo, L.P.N.; Esperança, J.M.S.S.; Rodríguez, A.. "On the hunt for truly biocompatible ionic liquids for lipase-catalyzed reactions". RSC Advances 5 5 (2015): 3386-3389. http://www.scopus.com/inward/record.url?eid=2-s2.0-84918808549&partnerID=MN8TOARS.
    10.1039/c4ra15021j
  43. Leal SS; Gomes CM. "Calcium dysregulation links ALS defective proteins and motor neuron selective vulnerability.". (2015): http://europepmc.org/abstract/med/26136661.
    10.3389/fncel.2015.00225
  44. Rodrigues, J.V.; Ruivo, D.; Rodríguez, A.; Deive, F.J.; Esperança, J.M.S.S.; Marrucho, I.M.; Gomes, C.M.; Rebelo, L.P.N.. "Structural-functional evaluation of ionic liquid libraries for the design of co-solvents in lipase-catalysed reactions". Green Chemistry 16 10 (2014): 4520-4523. http://www.scopus.com/inward/record.url?eid=2-s2.0-84907733329&partnerID=MN8TOARS.
    10.1039/c4gc01329h
  45. Henriques BJ; Lucas TG; Rodrigues JV; Frederiksen JH; Teixeira MS; Tiranti V; Bross P; Gomes CM. "Ethylmalonic encephalopathy ETHE1 R163W/R163Q mutations alter protein stability and redox properties of the iron centre.". (2014): http://europepmc.org/abstract/med/25198162.
    10.1371/journal.pone.0107157
  46. Correia AR; Naik S; Fisher MT; Gomes CM. "Probing the kinetic stabilities of Friedreich's ataxia clinical variants using a solid phase GroEL chaperonin capture platform.". (2014): http://europepmc.org/abstract/med/25333765.
    10.3390/biom4040956
  47. Côrte L; Valente F; Serrano M; Gomes CM; Moran CP Jr; Henriques AO. "A conserved cysteine residue of bacillus subtilis SpoIIIJ is important for endospore development.". (2014): http://europepmc.org/abstract/med/25133632.
    10.1371/journal.pone.0099811
  48. Gomes, C.M.; Santos, R.. "Neurodegeneration in Friedreich's ataxia: From defective frataxin to oxidative stress". Oxidative Medicine and Cellular Longevity (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84880857530&partnerID=MN8TOARS.
    10.1155/2013/487534
  49. Leal, S.S.; Cardoso, I.; Valentine, J.S.; Gomes, C.M.. "Calcium ions promote superoxide dismutase 1 (SOD1) aggregation into non-fibrillar amyloid: A link to toxic effects of calcium overload in amyotrophic lateral sclerosis (ALS)?". Journal of Biological Chemistry 288 35 (2013): 25219-25228. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883434936&partnerID=MN8TOARS.
    10.1074/jbc.M113.470740
  50. Carvalho, S.B.; Botelho, H.M.; Leal, S.S.; Cardoso, I.; Fritz, G.; Gomes, C.M.. "Intrinsically Disordered and Aggregation Prone Regions Underlie ß-Aggregation in S100 Proteins". PLoS ONE 8 10 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84884875081&partnerID=MN8TOARS.
    10.1371/journal.pone.0076629
  51. Farinha, C.M.; King-Underwood, J.; Sousa, M.; Correia, A.R.; Henriques, B.J.; Roxo-Rosa, M.; Da Paula, A.C.; et al. "Revertants, low temperature, and correctors reveal the mechanism of F508del-CFTR rescue by VX-809 and suggest multiple agents for full correction". Chemistry and Biology 20 7 (2013): 943-955. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880894290&partnerID=MN8TOARS.
    10.1016/j.chembiol.2013.06.004
  52. Cristóvão, J.S.; Leal, S.S.; Cardoso, I.; Gomes, C.M.. "Small molecules present in the cerebrospinal fluid metabolome influence superoxide dismutase 1 aggregation". International Journal of Molecular Sciences 14 9 (2013): 19128-19145. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884562833&partnerID=MN8TOARS.
    10.3390/ijms140919128
  53. Sá-Moura B; Simões AM; Fraga J; Fernandes H; Abreu IA; Botelho HM; Gomes CM; et al. "Biochemical and biophysical characterization of recombinant yeast proteasome maturation factor ump1.". (2013): http://europepmc.org/abstract/med/24688736.
    10.5936/csbj.201304006
  54. Rodrigues, J.V.; Henriques, B.J.; Lucas, T.G.; Gomes, C.M.. "Cofactors and metabolites as protein folding helpers in metabolic diseases". Current Topics in Medicinal Chemistry 12 22 (2012): 2546-2559. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874923658&partnerID=MN8TOARS.
    10.2174/1568026611212220009
  55. Rodrigues, J.V.; Gomes, C.M.. "Mechanism of superoxide and hydrogen peroxide generation by human electron-transfer flavoprotein and pathological variants". Free Radical Biology and Medicine 53 1 (2012): 12-19. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861542507&partnerID=MN8TOARS.
    10.1016/j.freeradbiomed.2012.04.016
  56. Leal, S.S.; Botelho, H.M.; Gomes, C.M.. "Metal ions as modulators of protein conformation and misfolding in neurodegeneration". Coordination Chemistry Reviews 256 19-20 (2012): 2253-2270. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864548981&partnerID=MN8TOARS.
    10.1016/j.ccr.2012.04.004
  57. Alves, E.; Henriques, B.J.; Rodrigues, J.V.; Prudêncio, P.; Rocha, H.; Vilarinho, L.; Martinho, R.G.; Gomes, C.M.. "Mutations at the flavin binding site of ETF: QO yield a MADD-like severe phenotype in Drosophila". Biochimica et Biophysica Acta - Molecular Basis of Disease 1822 8 (2012): 1284-1292. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861401412&partnerID=MN8TOARS.
    10.1016/j.bbadis.2012.05.003
  58. Veith, A.; Botelho, H.M.; Kindinger, F.; Gomes, C.M.; Kletzin, A.. "The sulfur oxygenase reductase from the mesophilic bacterium Halothiobacillus neapolitanus is a highly active thermozyme". Journal of Bacteriology 194 3 (2012): 677-685. http://www.scopus.com/inward/record.url?eid=2-s2.0-84855915891&partnerID=MN8TOARS.
    10.1128/JB.06531-11
  59. Gomes, C.M.. "Protein misfolding in disease and small molecule therapies". Current Topics in Medicinal Chemistry 12 22 (2012): 2460-2469. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874905513&partnerID=MN8TOARS.
    10.2174/1568026611212220002
  60. Botelho, H.M.; Leal, S.S.; Cardoso, I.; Yanamandra, K.; Morozova-Roche, L.A.; Fritz, G.; Gomes, C.M.. "S100A6 amyloid fibril formation is calcium-modulated and enhances superoxide dismutase-1 (SOD1) aggregation". Journal of Biological Chemistry 287 50 (2012): 42233-42242. http://www.scopus.com/inward/record.url?eid=2-s2.0-84871281215&partnerID=MN8TOARS.
    10.1074/jbc.M112.396416
  61. Silva, M.A.; Lucas, T.G.; Salgueiro, C.A.; Gomes, C.M.. "Protein Folding Modulates the Swapped Dimerization Mechanism of Methyl-Accepting Chemotaxis Heme Sensors". PLoS ONE 7 9 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84866983174&partnerID=MN8TOARS.
    10.1371/journal.pone.0046328
  62. Lucas, T.G.; Henriques, B.J.; Rodrigues, J.V.; Bross, P.; Gregersen, N.; Gomes, C.M.. "Cofactors and metabolites as potential stabilizers of mitochondrial acyl-CoA dehydrogenases". Biochimica et Biophysica Acta - Molecular Basis of Disease 1812 12 (2011): 1658-1663. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054078305&partnerID=MN8TOARS.
    10.1016/j.bbadis.2011.09.009
  63. Rodrigues, J.V.; Prosinecki, V.; Marrucho, I.; Rebelo, L.P.N.; Gomes, C.M.. "Protein stability in an ionic liquid milieu: On the use of differential scanning fluorimetry". Physical Chemistry Chemical Physics 13 30 (2011): 13614-13616. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960960628&partnerID=MN8TOARS.
    10.1039/c1cp21187k
  64. Henriques, B.J.; Fisher, M.T.; Bross, P.; Gomes, C.M.. "A polymorphic position in electron transfer flavoprotein modulates kinetic stability as evidenced by thermal stress". FEBS Letters 585 3 (2011): 505-510. http://www.scopus.com/inward/record.url?eid=2-s2.0-79551482638&partnerID=MN8TOARS.
    10.1016/j.febslet.2011.01.002
  65. Botelho, H.M.; Gomes, C.M.. "Structural reorganization renders enhanced metalloprotein stability". Chemical Communications 47 39 (2011): 11149-11151. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053318341&partnerID=MN8TOARS.
    10.1039/c1cc13354c
  66. Amaral, J.D.; Correia, A.R.; Steer, C.J.; Gomes, C.M.; Rodrigues, C.M.P.. "No evidence of direct binding between ursodeoxycholic acid and the p53 DNA-binding domain". Bioscience Reports 30 5 (2010): 359-364. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954733196&partnerID=MN8TOARS.
    10.1042/BSR20090107
  67. Botelho, H.M.; Leal, S.S.; Veith, A.; Prosinecki, V.; Bauer, C.; Fröhlich, R.; Kletzin, A.; Gomes, C.M.. "Role of a novel disulfide bridge within the all-beta fold of soluble Rieske proteins". Journal of Biological Inorganic Chemistry 15 2 (2010): 271-281. http://www.scopus.com/inward/record.url?eid=2-s2.0-77949270785&partnerID=MN8TOARS.
    10.1007/s00775-009-0596-3
  68. Henriques, B.J.; Bross, P.; Gomes, C.M.. "Mutational hotspots in electron transfer flavoprotein underlie defective folding and function in multiple acyl-CoA dehydrogenase deficiency". Biochimica et Biophysica Acta - Molecular Basis of Disease 1802 11 (2010): 1070-1077. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956649789&partnerID=MN8TOARS.
    10.1016/j.bbadis.2010.07.015
  69. Fritz, G.; Botelho, H.M.; Morozova-Roche, L.A.; Gomes, C.M.. "Natural and amyloid self-assembly of S100 proteins: Structural basis of functional diversity". FEBS Journal 277 22 (2010): 4578-4590. http://www.scopus.com/inward/record.url?eid=2-s2.0-78049277867&partnerID=MN8TOARS.
    10.1111/j.1742-4658.2010.07887.x
  70. Kim, S.; Leal, S.S.; Halevy, D.B.; Gomes, C.M.; Lev, S.. "Structural requirements for VAP-B oligomerization and their implication in amyotrophic lateral sclerosis-associated VAP-B(P56S) neurotoxicity". Journal of Biological Chemistry 285 18 (2010): 13839-13849. http://www.scopus.com/inward/record.url?eid=2-s2.0-77951559589&partnerID=MN8TOARS.
    10.1074/jbc.M109.097345
  71. Rodrigues, J.V.; Gomes, C.M.. "Enhanced superoxide and hydrogen peroxide detection in biological assays". Free Radical Biology and Medicine 49 1 (2010): 61-66. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953020725&partnerID=MN8TOARS.
    10.1016/j.freeradbiomed.2010.03.014
  72. Correia, A.R.; Wang, T.; Craig, E.A.; Gomes, C.M.. "Iron-binding activity in yeast frataxin entails a trade off with stability in the a1/ß1 acidic ridge region". Biochemical Journal 426 2 (2010): 197-203. http://www.scopus.com/inward/record.url?eid=2-s2.0-76549093324&partnerID=MN8TOARS.
    10.1042/BJ20091612
  73. Henriques, B.J.; Olsen, R.K.; Bross, P.; Gomes, C.M.. "Emerging roles for riboflavin in functional rescue of mitochondrial ß-oxidation flavoenzymes". Current Medicinal Chemistry 17 32 (2010): 3842-3854. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650709553&partnerID=MN8TOARS.
    10.2174/092986710793205462
  74. Henriques, B.J.; Rodrigues, J.V.; Olsen, R.K.; Bross, P.; Gomes, C.M.. "Role of flavinylation in a mild variant of multiple acyl-CoA dehydrogenation deficiency: A molecular rationale for the effects of riboflavin supplmentation". Journal of Biological Chemistry 284 7 (2009): 4222-4229. http://www.scopus.com/inward/record.url?eid=2-s2.0-63249105550&partnerID=MN8TOARS.
    10.1074/jbc.M805719200
  75. Correia, A.R.; Ow, S.Y.; Wright, P.C.; Gomes, C.M.. "The conserved Trp155 in human frataxin as a hotspot for oxidative stress related chemical modifications". Biochemical and Biophysical Research Communications 390 3 (2009): 1007-1011. http://www.scopus.com/inward/record.url?eid=2-s2.0-70449705810&partnerID=MN8TOARS.
    10.1016/j.bbrc.2009.10.095
  76. Botelho, H.M.; Koch, M.; Fritz, G.; Gomes, C.M.. "Metal ions modulate the folding and stability of the tumor suppressor protein S100A2". FEBS Journal 276 6 (2009): 1776-1786. http://www.scopus.com/inward/record.url?eid=2-s2.0-61349168402&partnerID=MN8TOARS.
    10.1111/j.1742-4658.2009.06912.x
  77. Boscolo, B.; Leal, S.S.; Salgueiro, C.A.; Ghibaudi, E.M.; Gomes, C.M.. "The prominent conformational plasticity of lactoperoxidase: A chemical and pH stability analysis". Biochimica et Biophysica Acta - Proteins and Proteomics 1794 7 (2009): 1041-1048. http://www.scopus.com/inward/record.url?eid=2-s2.0-67349089554&partnerID=MN8TOARS.
    10.1016/j.bbapap.2009.03.003
  78. Stelter, M.; Melo, A.M.P.; Pereira, M.M.; Gomes, C.M.; Hreggvidsson, G.O.; Hjorleifsdottir, S.; Saraiva, L.M.; Teixeira, M.; Archer, M.. "A novel type of monoheme cytochrome c: Biochemical and structural characterization at 1.23 Å resolution of Rhodothermus marinus cytochrome c". Biochemistry 47 46 (2008): 11953-11963. http://www.scopus.com/inward/record.url?eid=2-s2.0-56249143434&partnerID=MN8TOARS.
    10.1021/bi800999g
  79. Frazão, C.; Aragão, D.; Coelho, R.; Leal, S.S.; Gomes, C.M.; Teixeira, M.; Carrondo, M.A.. "Crystallographic analysis of the intact metal centres [3Fe-4S]1+/0 and [4Fe-4S]2+/1+ in a Zn2+-containing ferredoxin". FEBS Letters 582 5 (2008): 763-767. http://www.scopus.com/inward/record.url?eid=2-s2.0-39649092718&partnerID=MN8TOARS.
    10.1016/j.febslet.2008.01.041
  80. Faísca, P.F.N.; Gomes, C.M.. "On the relation between native geometry and conformational plasticity". Biophysical Chemistry 138 3 (2008): 99-106. http://www.scopus.com/inward/record.url?eid=2-s2.0-55549109717&partnerID=MN8TOARS.
    10.1016/j.bpc.2008.09.006
  81. Leal, S.S.; Gomes, C.M.. "On the relative contribution of ionic interactions over iron-sulfur clusters to ferredoxin stability". Biochimica et Biophysica Acta - Proteins and Proteomics 1784 11 (2008): 1596-1600. http://www.scopus.com/inward/record.url?eid=2-s2.0-54049123709&partnerID=MN8TOARS.
    10.1016/j.bbapap.2008.05.001
  82. Correia, A.R.; Pastore, C.; Adinolfi, S.; Pastore, A.; Gomes, C.M.. "Dynamics, stability and iron-binding activity of frataxin clinical mutants". FEBS Journal 275 14 (2008): 3680-3690. http://www.scopus.com/inward/record.url?eid=2-s2.0-50549100932&partnerID=MN8TOARS.
    10.1111/j.1742-4658.2008.06512.x
  83. Gouveia, R.M.; Gomes, C.M.; Sousa, M.; Alves, P.M.; Costa, J.. "Kinetic analysis of L1 homophilic interaction: Role of the first four immunoglobulin domains and implications on binding mechanism". Journal of Biological Chemistry 283 42 (2008): 28038-28047. http://www.scopus.com/inward/record.url?eid=2-s2.0-57649116073&partnerID=MN8TOARS.
    10.1074/jbc.M804991200
  84. Leandro, P.; Gomes, C.M.. "Protein misfolding in conformational disorders: Rescue of folding defects and chemical chaperoning". Mini-Reviews in Medicinal Chemistry 8 9 (2008): 901-911. http://www.scopus.com/inward/record.url?eid=2-s2.0-50149112642&partnerID=MN8TOARS.
    10.2174/138955708785132783
  85. Boscolo, B.; Leal, S.S.; Ghibaudi, E.M.; Gomes, C.M.. "Lactoperoxidase folding and catalysis relies on the stabilization of the a-helix rich core domain: A thermal unfolding study". Biochimica et Biophysica Acta - Proteins and Proteomics 1774 9 (2007): 1164-1172. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548311972&partnerID=MN8TOARS.
    10.1016/j.bbapap.2007.07.003
  86. Leal, S.S.; Gomes, C.M.. "Studies of the molten globule state of ferredoxin: Structural characterization and implications on protein folding and iron-sulfur center assembly". Proteins: Structure, Function and Genetics 68 3 (2007): 606-616. http://www.scopus.com/inward/record.url?eid=2-s2.0-34447549197&partnerID=MN8TOARS.
    10.1002/prot.21448
  87. Liz, M.A.; Gomes, C.M.; Saraiva, M.J.; Sousa, M.M.. "ApoA-I cleaved by transthyretin has reduced ability to promote cholesterol efflux and increased amyloidogenicity". Journal of Lipid Research 48 11 (2007): 2385-2395. http://www.scopus.com/inward/record.url?eid=2-s2.0-35848967214&partnerID=MN8TOARS.
    10.1194/jlr.M700158-JLR200
  88. Prosinecki, V.; Faísca, P.F.N.; Gomes, C.M.. "Conformational states and protein stability from a proteomic perspective". Current Proteomics 4 1 (2007): 44-52. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547638393&partnerID=MN8TOARS.
    10.2174/157016407781387375
  89. Todorovic, S.; Leal, S.S.; Salgueiro, C.A.; Zebger, I.; Hildebrandt, P.; Murgida, D.H.; Gomes, C.M.. "A spectroscopic study of the temperature induced modifications on ferredoxin folding and iron-sulfur moieties". Biochemistry 46 37 (2007): 10733-10738. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548694529&partnerID=MN8TOARS.
    10.1021/bi700967g
  90. Correia, A.R.; Adinolfi, S.; Pastore, A.; Gomes, C.M.. "Conformational stability of human frataxin and effect of Friedreich's ataxia-related mutations on protein folding". Biochemical Journal 398 3 (2006): 605-611. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748745306&partnerID=MN8TOARS.
    10.1042/BJ20060345
  91. Rocha, R.; Leal, S.S.; Teixeira, V.H.; Regalla, M.; Huber, H.; Baptista, A.M.; Soares, C.M.; Gomes, C.M.. "Natural domain design: Enhanced thermal stability of a zinc-lacking ferredoxin isoform shows that a hydrophobic core efficiently replaces the structural metal site". Biochemistry 45 34 (2006): 10376-10384. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748694511&partnerID=MN8TOARS.
    10.1021/bi0610698
  92. Prosinecki, V.; Botelho, H.M.; Francese, S.; Mastrobuoni, G.; Moneti, G.; Urich, T.; Kletzin, A.; Gomes, C.M.. "A proteomic approach toward the selection of proteins with enhanced intrinsic conformational stability". Journal of Proteome Research 5 10 (2006): 2720-2726. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750201140&partnerID=MN8TOARS.
    10.1021/pr0602491
  93. Henriques, B.J.; Saraiva, L.M.; Gomes, C.M.. "Combined spectroscopic and calorimetric characterisation of rubredoxin reversible thermal transition". Journal of Biological Inorganic Chemistry 11 1 (2006): 73-81. http://www.scopus.com/inward/record.url?eid=2-s2.0-29544441514&partnerID=MN8TOARS.
    10.1007/s00775-005-0055-8
  94. Urich, T.; Gomes, C.M.; Kletzin, A.; Frazão, C.. "X-ray structure of a self-compartmentalizing sulfur cycle metalloenzyme". Science 311 5763 (2006): 996-1000. http://www.scopus.com/inward/record.url?eid=2-s2.0-33144477916&partnerID=MN8TOARS.
    10.1126/science.1120306
  95. Leal, S.S.; Gomes, C.M.. "Linear three-iron centres are unlikely cluster degradation intermediates during unfolding of iron-sulfur proteins". Biological Chemistry 386 12 (2005): 1295-1300. http://www.scopus.com/inward/record.url?eid=2-s2.0-29044434890&partnerID=MN8TOARS.
    10.1515/BC.2005.147
  96. Henriques, B.J.; Saraiva, L.M.; Gomes, C.M.. "Probing the mechanism of rubredoxin thermal unfolding in the absence of salt bridges by temperature jump experiments". Biochemical and Biophysical Research Communications 333 3 (2005): 839-844. http://www.scopus.com/inward/record.url?eid=2-s2.0-20744443027&partnerID=MN8TOARS.
    10.1016/j.bbrc.2005.06.004
  97. Kletzin, A.; Ferreira, A.S.; Hechler, T.; Bandeiras, T.M.; Teixeira, M.; Gomes, C.M.. "A Rieske ferredoxin typifying a subtype within Rieske proteins: Spectroscopic, biochemical and stability studies". FEBS Letters 579 5 (2005): 1020-1026. http://www.scopus.com/inward/record.url?eid=2-s2.0-13844273334&partnerID=MN8TOARS.
    10.1016/j.febslet.2004.12.075
  98. Kletzin, A.; Urich, T.; Müller, F.; Bandeiras, T.M.; Gomes, C.M.. "Dissimilatory Oxidation and Reduction of Elemental Sulfur in Thermophilic Archaea". Journal of Bioenergetics and Biomembranes 36 1 (2004): 77-91. http://www.scopus.com/inward/record.url?eid=2-s2.0-10044244502&partnerID=MN8TOARS.
    10.1023/B:JOBB.0000019600.36757.8c
  99. Leal, S.S.; Teixeira, M.; Gomes, C.M.. "Studies on the degradation pathway of iron-sulfur centers during unfolding of a hyperstable ferredoxin: Cluster dissociation, iron release and protein stability". Journal of Biological Inorganic Chemistry 9 8 (2004): 987-996. http://www.scopus.com/inward/record.url?eid=2-s2.0-12144283882&partnerID=MN8TOARS.
    10.1007/s00775-004-0599-z
  100. Das, T.K.; Gomes, C.M.; Bandeiras, T.M.; Pereira, M.M.; Teixeira, M.; Rousseau, D.L.. "Active site structure of the aa3 quinol oxidase of Acidianus ambivalens". Biochimica et Biophysica Acta - Bioenergetics 1655 1-3 (2004): 306-320. http://www.scopus.com/inward/record.url?eid=2-s2.0-1942440337&partnerID=MN8TOARS.
    10.1016/j.bbabio.2003.08.011
  101. Müller, F.H.; Bandeiras, T.M.; Urich, T.; Teixeira, M.; Gomes, C.M.; Kletzin, A.. "Coupling of the pathway of sulphur oxidation to dioxygen reduction: Characterization of a novel membrane-bound thiosulphate:quinone oxidoreductase". Molecular Microbiology 53 4 (2004): 1147-1160. http://www.scopus.com/inward/record.url?eid=2-s2.0-4344594427&partnerID=MN8TOARS.
    10.1111/j.1365-2958.2004.04193.x
  102. Urich, T.; Bandeiras, T.M.; Leal, S.S.; Rachel, R.; Albrecht, T.; Zimmermann, P.; Scholz, C.; et al. "The sulphur oxygenase reductase from Acidianus ambivalens is a multimeric protein containing a low-potential mononuclear non-haem iron centre". Biochemical Journal 381 1 (2004): 137-146. http://www.scopus.com/inward/record.url?eid=2-s2.0-3142776185&partnerID=MN8TOARS.
    10.1042/BJ20040003
  103. Victor, B.L.; Vicente, J.B.; Rodrigues, R.; Oliveira, S.; Rodrigues-Pousada, C.; Frazão, C.; Gomes, C.M.; Teixeira, M.; Soares, C.M.. "Docking and electron transfer studies between rubredoxin and rubredoxin:oxygen oxidoreductase". Journal of Biological Inorganic Chemistry 8 4 (2003): 475-488. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037951339&partnerID=MN8TOARS.
  104. Hellwig, P.; Gomes, C.M.; Teixeira, M.. "FTIR spectroscopic characterization of the cytochrome aa3 from Acidianus ambivalens: Evidence for the involvement of acidic residues in redox coupled proton translocation". Biochemistry 42 20 (2003): 6179-6184. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038182934&partnerID=MN8TOARS.
    10.1021/bi0205348
  105. Bandeiras, T.M.; Salgueiro, C.A.; Huber, H.; Gomes, C.M.; Teixeira, M.. "The respiratory chain of the thermophilic archaeon Sulfolobus metallicus: Studies on the type-II NADH dehydrogenase". Biochimica et Biophysica Acta - Bioenergetics 1557 1-3 (2003): 13-19. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037422395&partnerID=MN8TOARS.
    10.1016/S0005-2728(02)00374-2
  106. Manuela M Pereira; Cláudio M Gomes; Miguel Teixeira; Pereira, M.M.; Gomes, C.M.; Teixeira, M.. "Plasticity of proton pathways in haem–copper oxygen reductases". FEBS Letters 522 1-3 (2002): 14-18. http://dx.doi.org/10.1016/s0014-5793(02)02920-4.
    10.1016/s0014-5793(02)02920-4
  107. Bandeiras, T.M.; Salgueiro, C.; Kletzin, A.; Gomes, C.M.; Teixeira, M.. "Acidianus ambivalens type-II NADH dehydrogenase: Genetic characterisation and identification of the flavin moiety as FMN". FEBS Letters 531 2 (2002): 273-277. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037032427&partnerID=MN8TOARS.
    10.1016/S0014-5793(02)03514-7
  108. Gomes, C.M.; Kletzin, A.; Teixeira, M.. "An archaeal b-type cytochrome containing a nonfunctional carbonic anhydrase-like domain". Journal of Biological Inorganic Chemistry 7 4-5 (2002): 483-489. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036941312&partnerID=MN8TOARS.
    10.1007/s00775-001-0323-1
  109. Gomes, C.M.; Giuffrè, A.; Forte, E.; Vicente, J.B.; Saraiva, L.M.; Brunori, M.; Teixeira, M.. "A novel type of nitric-oxide reductase: Escherichia coli flavorubredoxin". Journal of Biological Chemistry 277 28 (2002): 25273-25276. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037067737&partnerID=MN8TOARS.
    10.1074/jbc.M203886200
  110. Vicente, J.B.; Gomes, C.M.; Wasserfallen, A.; Teixeira, M.. "Module fusion in an A-type flavoprotein from the cyanobacterium Synechocystis condenses a multiple-component pathway in a single polypeptide chain". Biochemical and Biophysical Research Communications 294 1 (2002): 82-87. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036297346&partnerID=MN8TOARS.
    10.1016/S0006-291X(02)00434-5
  111. Jones, K.; Gomes, C.M.; Huber, H.; Teixeira, M.; Wittung-Stafshede, P.. "Formation of a linear [3Fe-4S] cluster in a seven-iron ferredoxin triggered by polypeptide unfolding". Journal of Biological Inorganic Chemistry 7 4-5 (2002): 357-362. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036937481&partnerID=MN8TOARS.
    10.1007/s00775-001-0304-4
  112. Gomes, C.M.; Frazão, C.; Xavier, A.V.; Legall, J.; Teixeira, M.. "Functional control of the binuclear metal site in the metallo-ß-lactamase-like fold by subtle amino acid replacements". Protein Science 11 3 (2002): 707-712. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036176228&partnerID=MN8TOARS.
    10.1110/ps.31202
  113. Lemos, R.S.; Fernandes, A.S.; Pereira, M.M.; Gomes, C.M.; Teixeira, M.. "Quinol:fumarate oxidoreductases and succinate:quinone oxidoreductases: Phylogenetic relationships, metal centres and membrane attachment". Biochimica et Biophysica Acta - Bioenergetics 1553 1-2 (2002): 158-170. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037122944&partnerID=MN8TOARS.
    10.1016/S0005-2728(01)00239-0
  114. Lemos, R.S.; Gomes, C.M.; LeGall, J.; Xavier, A.V.; Teixeira, M.. "The quinol:fumarate oxidoreductase from the sulphate reducing bacterium Desulfovibrio gigas: Spectroscopic and redox studies". Journal of Bioenergetics and Biomembranes 34 1 (2002): 21-30. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036168642&partnerID=MN8TOARS.
    10.1023/A:1013814619023
  115. Gomes, C.M.; Bandeiras, T.M.; Teixeira, M.. "A new type-II NADH dehydrogenase from the archaeon acidianus ambivalens: Characterization and in vitro reconstitution of the respiratory chain". Journal of Bioenergetics and Biomembranes 33 1 (2001): 1-8. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035070335&partnerID=MN8TOARS.
    10.1023/A:1005630221892
  116. Gomes, C.M.; Le Gall, J.; Xavier, A.V.; Teixeira, M.. "Could a diiron-containing four-helix-bundle protein have been a primitive oxygen reductase?". ChemBioChem 2 7-8 (2001): 583-587. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035800902&partnerID=MN8TOARS.
  117. Moczygemba, C.; Guidry, J.; Jones, K.L.; Gomes, C.M.; Teixeira, M.; Wittung-Stafshede, P.. "High stability of a ferredoxin from the hyperthermophilic archaeon A. ambivalens: Involvement of electrostatic interactions and cofactors". Protein Science 10 8 (2001): 1539-1548. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034926051&partnerID=MN8TOARS.
    10.1110/ps.49401
  118. Gilderson, G.; Aagaard, A.; Gomes, C.M.; Ädelroth, P.; Teixeira, M.; Brzezinski, P.. "Kinetics of electron and proton transfer during O2 reduction in cytochrome aa3 from A. ambivalens: An enzyme lacking Glu(I-286)". Biochimica et Biophysica Acta - Bioenergetics 1503 3 (2001): 261-270. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035910668&partnerID=MN8TOARS.
    10.1016/S0005-2728(00)00195-X
  119. Lemos, R.S.; Gomes, C.M.; Teixeira, M.. "Acidianus ambivalens complex ii typifies a novel family of succinate dehydrogenases". Biochemical and Biophysical Research Communications 281 1 (2001): 141-150. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034810204&partnerID=MN8TOARS.
    10.1006/bbrc.2001.4317
  120. Gomes, C.M.; Backgren, C.; Teixeira, M.; Puustinen, A.; Verkhovskaya, M.L.; Wikström, M.; Verkhovsky, M.I.. "Heme-copper oxidases with modified D- and K-pathways are yet efficient proton pumps". FEBS Letters 497 2-3 (2001): 159-164. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035947367&partnerID=MN8TOARS.
    10.1016/S0014-5793(01)02431-0
  121. Lemos, R.S.; Gomes, C.M.; Santana, M.; LeGall, J.; Xavier, A.V.; Teixeira, M.. "The 'strict' anaerobe Desulfovibrio gigas contains a membrane-bound oxygen-reducing respiratory chain". FEBS Letters 496 1 (2001): 40-43. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035805166&partnerID=MN8TOARS.
    10.1016/S0014-5793(01)02399-7
  122. Frazão, C.; Silva, G.; Gomes, C.M.; Matias, P.; Coelho, R.; Sieker, L.; Macedo, S.; et al. "Structure of a dioxygen reduction enzyme from Desulfovibrio gigas". Nature Structural Biology 7 11 (2000): 1041-1045. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033767236&partnerID=MN8TOARS.
    10.1038/80961
  123. Gomes, C.M.; Vicente, J.B.; Wasserfallen, A.; Teixeira, M.. "Spectroscopic studies and characterization of a novel electron-transfer chain from Escherichia coli involving a flavorubredoxin and its flavoprotein reductase partner". Biochemistry 39 51 (2000): 16230-16237. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034719146&partnerID=MN8TOARS.
    10.1021/bi001844y
  124. Wittung-Stafshede, P.; Gomes, C.M.; Teixeira, M.. "Stability and folding of the ferredoxin from the hyperthermophilic archaeon Acidianus ambivalens". Journal of Inorganic Biochemistry 78 1 (2000): 35-41. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034651201&partnerID=MN8TOARS.
    10.1016/S0162-0134(99)00202-0
  125. Silva, G.; Oliveira, S.; Gomes, C.M.; Pacheco, I.; Liu, M.Y.; Xavier, A.V.; Teixeira, M.; LeGall, J.; Rodrigues-Pousada, C.. "Desulfovibrio gigas neelaredoxin: A novel superoxide dismutase integrated in a putative oxygen sensory operon of an anaerobe". European Journal of Biochemistry 259 1-2 (1999): 235-243. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033556244&partnerID=MN8TOARS.
    10.1046/j.1432-1327.1999.00025.x
  126. Romão, C.V.; Liu, M.Y.; Le Gall, J.; Gomes, C.M.; Braga, V.; Pacheco, I.; Xavier, A.V.; Teixeira, M.. "The superoxide dismutase activity of desulfoferrodoxin from Desulfovibrio desulfuricans ATCC 27774". European Journal of Biochemistry 261 2 (1999): 438-443. http://www.scopus.com/inward/record.url?eid=2-s2.0-0001473620&partnerID=MN8TOARS.
    10.1046/j.1432-1327.1999.00278.x
  127. Gomes, C.M.; Lemos, R.S.; Teixeira, M.; Kletzin, A.; Huber, H.; Stetter, K.O.; Schäfer, G.; Anemüller, S.. "The unusual iron sulfur composition of the Acidianus ambivalens succinate dehydrogenase complex". Biochimica et Biophysica Acta - Bioenergetics 1411 1 (1999): 134-141. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032941787&partnerID=MN8TOARS.
    10.1016/S0005-2728(99)00046-8
  128. Aagaard, A.; Gilderson, G.; Gomes, C.M.; Teixeira, M.; Brzezinski, P.. "Dynamics of the binuclear center of the quinol oxidase from Acidianus ambivalens". Biochemistry 38 31 (1999): 10032-10041. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033520113&partnerID=MN8TOARS.
    10.1021/bi990473m
  129. Das, T.K.; Gomes, C.M.; Teixeira, M.; Rousseau, D.L.. "Redox-linked transient deprotonation at the binuclear site in the aa3- type quinol oxidase from Acidianus ambivalens: Implications for proton translocation". Proceedings of the National Academy of Sciences of the United States of America 96 17 (1999): 9591-9596. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033578373&partnerID=MN8TOARS.
    10.1073/pnas.96.17.9591
  130. Gomes, C.M.; Teixeira, M.. "Ambineela, an unusual blue protein isolated from the archaeon acidianus ambivalens". Biochemical and Biophysical Research Communications 249 1 (1998): 23-25. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032504525&partnerID=MN8TOARS.
    10.1006/bbrc.1998.9020
  131. LeGall, J.; Liu, M.Y.; Gomes, C.M.; Braga, V.; Pacheco, I.; Regalla, M.; Xavier, A.V.; Teixeira, M.. "Characterisation of a new rubredoxin isolated from Desulfovibrio desulfuricans 27774: Definition of a new family of rubredoxins". FEBS Letters 429 3 (1998): 295-298. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032537511&partnerID=MN8TOARS.
    10.1016/S0014-5793(98)00610-3
  132. Gomes, C.M.; Teixeira, M.. "The NADH oxidase from the thermoacidophilic archaea Acidianus ambivalens: Isolation and physicochemical characterisation". Biochemical and Biophysical Research Communications 243 2 (1998): 412-415. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032512572&partnerID=MN8TOARS.
    10.1006/bbrc.1998.8111
  133. Gomes, C.M.; Faria, A.; Carita, J.C.; Mendes, J.; Regalia, M.; Chicau, P.; Huber, H.; Stetter, K.O.; Teixeira, M.. "Di-cluster, seven-iron ferredoxins from hyperthermophilic Sulfolobales". Journal of Biological Inorganic Chemistry 3 5 (1998): 499-507. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031753233&partnerID=MN8TOARS.
    10.1007/s007750050260
  134. Gomes, C.M.; Huber, H.; Stetter, K.O.; Teixeira, M.. "Evidence for a novel type of iron cluster in the respiratory chain of the archaeon Sulfolobus metallicus". FEBS Letters 432 3 (1998): 99-102. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031718523&partnerID=MN8TOARS.
    10.1016/S0014-5793(98)00836-9
  135. Gomes, C.M.; Silva, G.; Oliveira, S.; LeGall, J.; Liu, M.-Y.; Xavier, A.V.; Rodrigues-Pousada, C.; Teixeira, M.. "Studies on the redox centers of the terminal oxidase from Desulfovibrio gigas and evidence for its interaction with rubredoxin". Journal of Biological Chemistry 272 36 (1997): 22502-22508. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030954667&partnerID=MN8TOARS.
    10.1074/jbc.272.36.22502
  136. Giuffrè, A.; Gomes, C.M.; Antonini, G.; D'Itri, E.; Teixeira, M.; Brunori, M.. "Functional properties of the quinol oxidase from Acidianus ambivalens and the possible catalytic role of its electron donor Studies on the membrane-integrated and purified enzyme". European Journal of Biochemistry 250 2 (1997): 383-388. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031465914&partnerID=MN8TOARS.
  137. Teixeira, M.; Batista, R.; Campos, A.P.; Gomes, C.; Mendes, J.; Pacheco, I.; Anemuller, S.; Hagen, W.R.. "A Seven-iron Ferredoxin from the Thermoacidophilic Archaeon Desulfurolobus ambivalens". European Journal of Biochemistry 227 1-2 (1995): 322-327. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028895764&partnerID=MN8TOARS.
    10.1111/j.1432-1033.1995.tb20392.x
Capítulo de livro
  1. Cláudio M. Gomes. "Metals and amyloid gain-of-toxic mechanisms in neurodegenerative diseases". 2020.
    10.1016/b978-0-12-819132-3.00009-9
  2. Cláudio M. Gomes. "Riboflavin (vitamin B2) and mitochondrial energy". 2020.
    10.1016/b978-0-12-811907-5.00011-7
  3. Lucas, T.G.; Gomes, C.M.; Henriques, B.J.. "Thermal shift and stability assays of disease-related misfolded proteins using differential scanning fluorimetry". 255-264. 2019.
    10.1007/978-1-4939-8820-4_16
  4. Cristóvão, J.S.; Henriques, B.J.; Gomes, C.M.. "Biophysical and spectroscopic methods for monitoring protein misfolding and amyloid aggregation". 3-18. 2019.
    10.1007/978-1-4939-8820-4_1
  5. Martínez, J.; Cristóvão, J.S.; Sánchez, R.; Gasset, M.; Gomes, C.M.. "Preparation of amyloidogenic aggregates from EF-hand ß-parvalbumin and S100 proteins". 167-179. 2018.
    10.1007/978-1-4939-7816-8_11
  6. Carvalho, S.B.; Cardoso, I.; Botelho, H.M.; Yanamandra, K.; Fritz, G.; Gomes, C.M.; Morozova-Roche, L.A.. "Structural Heterogeneity and Bioimaging of S100 Amyloid Assemblies". In Bio-nanoimaging Protein Misfolding and Aggregation 2014, Pages 197-212, 197-212. Academic Press / Elsevier, 2014.
    Publicado • 10.1016/B978-0-12-394431-3.00018-3
  7. Botelho, Hugo M.; Fritz, Günter; Gomes, Cláudio M.. "Analysis of S100 Oligomers and Amyloids". In Methods in Molecular Biology, 373-386. Humana Press, 2012.
    10.1007/978-1-61779-551-0_25
  8. Henriques, Bárbara J.; Rodrigues, João V.; Gomes, Cláudio M.. "Riboflavin and ß-oxidation Flavoenzymes". In Food and Nutritional Components in Focus, 611-632. Royal Society of Chemistry, 2012.
    10.1039/9781849734714-00611
  9. Gomes, C.M.; Wittung-Stafshede, P.. "Metal ions, protein folding, and conformational states: an introduction". 3-11. CRC Press, 2010.
    Publicado
  10. Leal, S.S.; Gomes, C.M.. "Iron-sulfur clusters, protein folds, and ferredoxin stability". 81-96. CRC Press, 2010.
Edição de livro
  1. Cláudio M. Gomes. The Biochemistry of Amyloids in Neurodegenerative Diseases, Volume I. Frontiers Media SA. 2022.
    Publicado • 10.3389/978-2-88974-251-6 • Editor
  2. Cláudio M. Gomes. "Protein Misfolding Diseases - Methods and Protocols" - Methods in Molecular Biology. New York, NY, Estados Unidos: Springer New York. 2019.
    Publicado • 10.1007/978-1-4939-8820-4 • Editor
  3. Gomes, C.M.; Wittung-Stafshede, P.; Cláudio Gomes; Pernilla Wittung-Stafshede. Protein folding and metal ions: Mechanisms, biology and disease. Estados Unidos: CRC Press. 2010.
    Publicado • 10.1201/b10278 • Editor
Edição de número de revista
  1. Cláudio M. Gomes; Jinghui Luo; Wolfgang Hoyer. "The Biochemistry of Amyloids in Neurodegenerative Diseases, Volume II". Frontiers in Neuroscience (2022): https://www.frontiersin.org/research-topics/26380/the-biochemistry-of-amyloids-in-neurodegenerative-diseases-volume-ii.
    Editor convidado
  2. Cláudio M. Gomes; Jinghui Luo; Wolfgang Hoyer. "The Biochemistry of Amyloids in Neurodegenerative Diseases, Volume I". Frontiers in Neuroscience (2021): https://www.frontiersin.org/research-topics/13519/the-biochemistry-of-amyloids-in-neurodegenerative-diseases-volume-i.
    Publicado • Editor convidado
  3. Cláudio M. Gomes; Henriques, Bárbara J. "Protein Folding Diseases - Molecular Mechanisms and Therapeutic Approaches". International Journal of Molecular Sciences (2020): https://www.mdpi.com/journal/ijms/special_issues/protein_fold_dis.
    Editor convidado
  4. Andreas M. Grabrucker; Bernadeta Szewczyk; Cláudio M. Gomes. "Neuro-Metallomics: Molecular Biology of Trace Metals in the Brain". Frontiers in Molecular Neuroscience (2017):
    Publicado • Editor
  5. Renata Santos; Anne-Laure Bulteau; Cláudio M. Gomes. "Neurodegeneration, Neurogenesis, and Oxidative Stress 2015". Oxidative Medicine and Cellular Longevity 2016 (2016):
    Publicado • 10.1155/2016/7632025 • Editor
  6. Renata Santos; Carmen Ruiz de Almodóvar; Anne-Laure Bulteau; Cláudio M. Gomes. "Neurodegeneration, neurogenesis, and oxidative stress 2013". Oxidative Medicine and Cellular Longevity (2013): http://europepmc.org/abstract/med/24371504.
    10.1155/2013/730581 • Editor
  7. Gomes, C.M.. "Protein misfolding in conformational disorders". Current Topics in Medicinal Chemistry 12 22 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84874830615&partnerID=MN8TOARS.
    Publicado • 10.2174/1568026611212220001 • Editor
Livro
  1. Gomes, Cláudio M.; Faísca, Patrícia F.N.. Protein Folding - An Introduction. Springer International Publishing. 2019.
    Publicado • 10.1007/978-3-319-00882-0
Poster em conferência
  1. Margarida C. Simões; Joana S. Cristóvão; Els Pardon; Jan Steyaert; Cláudio M. Gomes. Autor correspondente: Cláudio M. Gomes. "Nanobodies as protein-based tools to modulate Tau aggregation in Alzheimer's disease". Trabalho apresentado em Ciências Research and Innovation Day 2023, 2023.
  2. António J. Figueira; Cláudio M. Gomes. "Aß42 aggregation and oligomerization is regulated by S100B chaperone multimers". Trabalho apresentado em Susan Lindquist School on Proteostasis, 2023.
  3. Saavedra, Joana; Nascimento, Mariana; Cláudio M. Gomes; Cardoso, Isabel. "Factors affecting S100B expression in Alzheimer´s disease: Evidence from a mouse model and a neuronal cell line". Trabalho apresentado em IBRO World Congress of Neuroscience (IBRO 2023), 2023.
  4. Margarida C. Simões; Joana S. Cristóvão; Els Pardon; Jan Steyaert; Cláudio M. Gomes. Autor correspondente: Cláudio M. Gomes. "Single-domain antibodies against S100B activate its chaperone function and modulate Tau/K18 aggregation". Trabalho apresentado em FEBS advanced course: Protein folding, aggregation and compartmentalization, 2023.
  5. António J. Figueira; Cláudio M. Gomes. "S100B chaperone multimers suppress Aß42 aggregation and oligomer formation". Trabalho apresentado em 5th International Symposium on Pathomechanisms of Amyloid Diseases, 2023.
  6. Henriques, Bárbara J; Joana V. Ribeiro; Cláudio M. Gomes. "Protein misfolding in Glutaric Aciduria-type I: from protein defects to function regulation by cofactor and substrate". Trabalho apresentado em EBSA Congress 2023, 2023.
  7. Joana V. Ribeiro; Magalhães, Pedro R.; Faustino, Hélio; Pedro M. P. Góis; Victor, Bruno; Cláudio M. Gomes; Henriques, Bárbara J. "Potential regulatory role of succinylation on electron transfer flavoprotein, a key protein in mitochondrial metabolism". Trabalho apresentado em EBSA Congress 2023, 2023.
  8. Cláudio M. Gomes; Guilherme G. Moreira. Autor correspondente: Cláudio M. Gomes. "Chaperone modulation of tau liquid liquid phase separation". Trabalho apresentado em 14th EBSA Congress 2023, Aula Magna of Stockholm¿s University, Sweden, 2023.
  9. Ruy M Domingos; Joana V. Ribeiro; Cláudio M. Gomes; Henriques, Bárbara J; Domingos, Ruy; Joana Valente Ribeiro. Autor correspondente: Henriques, Bárbara J. "Impact of non-enzymatic post-translational modifications on fatty acid oxidation enzymes". Trabalho apresentado em 3rd Chem & Biochem Students Meeting, 2023.
  10. Santos, Mariana; Ventura, Inês; Cláudio M. Gomes; Santos, Romana; Henriques, Bárbara. "Developing Synthetic Adhesive Proteins Inspired by Sea Urchin Nectin Structural Domains". Trabalho apresentado em 3rd Chem & Biochem Students Meeting, 2023.
  11. Margarida C. Simões; Joana S. Cristóvão; Els Pardon; Jan Steyaert; Cláudio M. Gomes. Autor correspondente: Cláudio M. Gomes. "Single-domain antibodies as tools for controlling Tau aggregation in neurodegenerative diseases". Trabalho apresentado em 3rd Chem&Biochem Students Meeting, 2023.
  12. de Freitas, Daniela P.; Guilherme G. Moreira; António J. Figueira; Cláudio M. Gomes. Autor correspondente: de Freitas, Daniela P.. "Exploring Early Disease Mechanisms: Cross-Interactions between Aß and Tau in Alzheimer's Disease". Trabalho apresentado em 3rd Chem&Biochem Students Meeting, 2023.
  13. Ventura, Inês; Santos, Mariana; Cláudio M. Gomes; Henriques, Bárbara; Santos, Romana. "A Sticky Research - Sea Urchin Bioinspired Adhesive Proteins". Trabalho apresentado em SynBioBeta 2023, 2023.
  14. Nascimento, Mariana; Saavedra, Joana; Cláudio M. Gomes; Cardoso, Isabel. "Finding a link between S100B and Transthyretin, two proteins with anti-aggregation properties against Aß peptide". Trabalho apresentado em Encontro de Investigação Jovem 2023 (IJUP 2023), 2023.
  15. Saavedra, Joana; Nascimento, Mariana; Cláudio M. Gomes; Cardoso, Isabel. "Transthyretin insufficiency induces brain S100B expression in an Alzheimer's Disease mouse model". Trabalho apresentado em FENS regional meeting 2023, 2023.
  16. Nascimento, Mariana; Saavedra, Joana; Cláudio M. Gomes; Cardoso, Isabel. "Oligomeric Aß increases S100B expression in the SH-SY5Y cell line: implications in Alzheimer´s Disease". Trabalho apresentado em FENS regional meeting 2023, 2023.
  17. Margarida C. Simões; Joana S. Cristóvão; Els Pardon; Jan Steyaert; Cláudio M. Gomes. Autor correspondente: Cláudio M. Gomes. "Anti-S100B nanobodies as modulators of Tau aggregation". Trabalho apresentado em EuroTau 2023, 2023.
  18. Guilherme G. Moreira; Cláudio M. Gomes. "S100B chaperone regulates tau liquid-liquid phase separation". Trabalho apresentado em EuroTau 2023 Meeting, 2023.
  19. Ventura, Inês; Santos, Mariana R; Cláudio M. Gomes; Henriques, Bárbara; Santos, Romana. "A Sticky Research - Bioinspired adhesive proteins from marine organisms". Trabalho apresentado em TWIN2PIPSA - Twinning for Excellence in Biophysics of Protein Interactions and Self-Assembly Kick-Off Meeting, 2023.
  20. Joana Valente Ribeiro; Cláudio M. Gomes; Henriques, Bárbara J. "Protein misfolding in mitochondrial aminoacyl-tRNA synthetase related neurological disease". Trabalho apresentado em TWIN2PIPSA Kick-off Meeting, Faculty of Sciences University of Lisbon, Lisbon, Portugal, 2023.
  21. Guilherme G. Moreira; Cláudio M. Gomes. Autor correspondente: Cláudio M. Gomes. "Tau liquid-liquid phase separation is modulated by the Ca2+-switched chaperone activity of the S100B protein". Trabalho apresentado em TWIN2PIPSA - Twinning for Excellence in Biophysics of Protein Interactions and Self-Assembly Kick-Off Meeting, 2023.
  22. Margarida C. Simões; Joana S. Cristóvão; Els Pardon; Jan Steyaert; Cláudio M. Gomes. Autor correspondente: Cláudio M. Gomes. "Single-domain antibodies targeting S100B as tools in Alzheimer's disease". Trabalho apresentado em 6º Conferência Anual da RedeSAÚDE (Prémios ULisboa - Rede Saúde 2022), 2022.
  23. Joana V. Ribeiro; Guilherme G. Moreira; António J. Figueira; Mariana Romão; Coelho, Romina; Margarida C. Simões; de Freitas, Daniela P.; et al. "Research on Protein Folding Diseases at the Protein Misfolding and Amyloids in Biomedicine Laboratory". Trabalho apresentado em Ciências Research Day 2022, 2022.
  24. António J. Figueira; Guilherme G. Moreira; Joana Saavedra; Isabel Cardoso; Cláudio M. Gomes; Saavedra, Joana; Cardoso, Isabel. Autor correspondente: Cláudio M. Gomes. "Tetramerization of the Synaptic S100B Chaperone Enhances Anti-aggregation Activity and Client Specificity". Trabalho apresentado em The Leuven Protein Aggregation Meeting, 2022.
  25. Filipa S. Carvalho; Vukosava M Torres; Joana V. Ribeiro; Botelho, Hugo; Vilarinho, Laura; Cláudio M. Gomes; Henriques, Bárbara J. "Mitochondria phenotype and metabolomic signature in MADD patient-derived fibroblasts". Trabalho apresentado em SSIEM 2022 Annual Symposium, 2022.
  26. Joana V. Ribeiro; Magalhães, Pedro R.; Joana F. Ferreira; Faustino, Hélio; Pedro M. P. Góis; Cláudio M. Gomes; Victor, Bruno; Henriques, Bárbara J. "Non-enzymatic succinylation of electron transfer flavoprotein ¿ potential implications on multiple acyl-CoA dehydrogenase deficiency". Trabalho apresentado em SSIEM Annual Symposium 2022, 2022.
  27. de Freitas, Daniela P.; Guilherme G. Moreira; Cláudio M. Gomes. "Extracellular regulation of tau aggregation and amyloid cross-interactions in Alzheimer's disease". Trabalho apresentado em 2nd Chem&Biochem Students Meeting, 2022.
  28. António J. Figueira; Cristóvão, Joana S.; Cláudio M. Gomes; Joana Cristóvão; Carapeto, Ana; Mario S Rodrigues; Isabel Cardoso. "Astrocytic S100B protein acts as Dual-Function Chaperone inhibiting aggregation and preventing the formation of zinc-induced toxic Aß Oligomers". Trabalho apresentado em The Biochemistry Global Summit ¿ 25th IUBMB, 46th FEBS and 15th PABMB Congresses, 2022.
  29. Guilherme G. Moreira; António J. Figueira; Quezada, Andrea; Filipa S. Carvalho; Mariana Romão; Coelho, Romina; Joana S. Cristóvão; et al. "A novel chaperone protein in the human brain that inhibits protein aggregation and toxicity in neurodegenerative dementias". Trabalho apresentado em Ciências Research Day 2021, 2021.
  30. Guilherme G. Moreira; Quezada, Andrea; Herrera, Federico; Cláudio M. Gomes. "Tau puncta and liquid-liquid phase separation are precluded by the S100B protein chaperone". Trabalho apresentado em Third Eurotau Meeting, 2021.
  31. Diogo Ferreira; Hathazi, Denisa; Horvath, Hilda; Cláudio M. Gomes; Henriques, Bárbara J. "On the track of mitochondrial aminoacyl-tRNA synthetase-related neurological diseases - Expression and purification of EARS2 protein". Trabalho apresentado em 17th International Symposium of the Portuguese Society for Metabolic Disorders (SPDM), 2021.
  32. Joana V. Ribeiro; Magalhães, Pedro R.; Joana F. Ferreira; Faustino, Hélio; Pedro M. P. Góis; Cláudio M. Gomes; Victor, Bruno; Henriques, Bárbara J. "Structural impact of succinylation on Electron Transfer Flavoprotein function". Trabalho apresentado em 17th International Symposium of SPDM, 2021.
  33. Filipa S. Carvalho; Joana V. Ribeiro; Vilarinho, Laura; Cláudio M. Gomes; Henriques, Bárbara J. "Multiple Acyl-CoA dehydrogenase deficiency: mitochondria characterization in patients-derived fibroblasts". Trabalho apresentado em 17th International Symposium of the Portuguese Society for Metabolic Disorders (SPDM), 2021.
  34. Joana V. Ribeiro; Cláudio M. Gomes; Henriques, Bárbara J. "Riboflavin supplementation in GA-I patients - a molecular rationale for a possible beneficial effect". Trabalho apresentado em 55th Annual Scientific Meeting ¿ ESCI, 2021.
  35. Lucas, Tânia G.; Henriques, Bárbara J; Cláudio M. Gomes. "Protein conformational analysis - a key tool to understand multiple acyl-CoA dehydrogenase deficiency (MADD)". Trabalho apresentado em 16th International Symposium of the Portuguese Society for Metabolic Disorders (SPDM), 2020.
  36. Joana V. Ribeiro; Cláudio M. Gomes; Henriques, Bárbara J. "Molecular rationale for riboflavin treatment in Glutaric Aciduria Type I patients". Trabalho apresentado em 16th International SPDM Symposium, 2020.
  37. Joana V. Ribeiro; Cláudio M. Gomes; Henriques, Bárbara J. "Rescue of disease associated folding defects by flavin cofactor ¿ the case of glutaryl-CoA dehydrogenase". Trabalho apresentado em Living Molecules: towards Integrative Biophysics of the Cell, 2020.
  38. André Ventura; Bárbara J. Henriques; Cláudio M. Gomes; Santos, Romana. "Identification of amyloid traits in tube feet and adhesive footprints of the sea urchin Paracentrotus lividus". Trabalho apresentado em 4th International Conference on Biological and Biomimetic Adhesives, 2020.
  39. Guilherme G. Moreira; Joana S. Cristovão; V. M. Torres; A. P. Carapeto; Mário S. Rodrigues; I. Landrieu; C. Cordeiro; Cláudio M. Gomes. "Zinc binding alters Tau Aggregation and oligomer formation". Trabalho apresentado em 5th PhD Student Meeting of The Mind-Brain College, Rectory of the University of Lisbon, Lisbon, Portugal, 2019.
  40. Joana V. Ribeiro; Lucas, Tânia G.; Bross, Peter; Cláudio M. Gomes; Henriques, Bárbara J. "Defective protein folding in metabolic diseases: the impact of clinical mutations on Glutaryl-CoA Dehydrogenase". Trabalho apresentado em EMBO Workshop - Proteostasis: From organelles to organisms, 2019.
  41. G. G. Moreira; J. S. Cristovão; V. M. Torres; Carapeto, Ana; M. S. Rodrigues; C. Cordeiro; I. Landrieu; Cláudio M. Gomes. "Biophysical studies on Tau aggregation and metal ion binding". Trabalho apresentado em Molecular Biophysics ¿ ABC of the Puzzle of Life, Zagreb, Croatia, 2019.
  42. Guilherme G. Moreira; Joana S. Cristovão; Carapeto, Ana; Mário S. Rodrigues; I. Landrieu; Cláudio M. Gomes. "Tau Aggregation Kinetics and Bioimaging". Trabalho apresentado em 4th PhD Student Meeting of the Mind-Brain Colege, Rectory of the University of Lisbon, Lisbon, Portugal, 2018.
  43. Guilherme G. Moreira; Joana S. Cristovão; Carapeto, Ana; Mário S. Rodrigues; I. Landrieu; Cláudio M. Gomes. "Aggregation kinetics and bioimaging of monomeric tau". Trabalho apresentado em Workshop on Integrative Approaches in Neurodegeneration, Lisbon, Portugal, 2018.
  44. Joana S. Cristovão; S. Hagmeyer; Carapeto, Ana; I. Cardoso; Mário S. Rodrigues; A. M. Grabrucker; Cláudio M. Gomes. "S100B is a neuronal zinc chelator that modulates zinc driven AB42 oligomerization in Alzheimer's disease". Trabalho apresentado em Workshop on Integrative Approaches in Neurodegeneration, Lisbon, Portugal, 2018.
    10.1149/1.2215512
  45. Joana V. Ribeiro; Lucas, Tânia G.; Bross, Peter; Cláudio M. Gomes; Henriques, Bárbara J. "Impact of Clinical Glutaric Aciduria Type I Mutations on Glutaryl-CoA Dehydrogenase Structure and Function". Trabalho apresentado em 14th International SPDM Symposium, 2018.
  46. Sofia B Carvalho; Sónia S. Leal; Botelho, Hugo M; Isabel Cardoso; Günter Fritz; Cláudio M. Gomes. "Cross talks between amyloid-forming proteins in neurodegeneration". Trabalho apresentado em 9th EBSA European Biophysics Congress, 2013.
  47. Botelho, Hugo M; Christine Betz; Katrin Kierdorf; Marco Prinz; Cláudio M. Gomes; Günter Fritz. "A new emerging role of S100B in amyloid plaque formation". Trabalho apresentado em 56th Annual Meeting, German Society for Neuropathology and Neuroanatomy, 2011.
    10.5414/npp30245
Prefácio / Posfácio
  1. Gomes, C.M.. "Preface to Methods in Molecular Biology "Protein Misfolding Diseases - Methods and Protocols"". Prefácio para Methods in Molecular Biology. 2019.
    Publicado
  2. Gomes, C.M.; Wittung-Stafshede, P.. "Preface to the Book "Protein Folding and Metal Ions: Mechanisms, Biology and Disease"". Prefácio para Protein Folding and Metal Ions: Mechanisms, Biology and Disease. Estados Unidos: CRC Press. 2016.
    Publicado
  3. Gomes, C.M.; Wittung-Stafshede, P.. "About the Editors "Protein Folding and Metal Ions: Mechanisms, Biology and Disease"". Prefácio para Protein Folding and Metal Ions: Mechanisms, Biology and Disease, editado por CRC Press. 2016.
    Publicado
Recurso online
  1. Henriques, Bárbara J; Katrine Jentoft Olsen, Rikke; Cláudio M. Gomes; Peter Bross. ETFA gene wikipedia page - target to general audience (PUBLIC OUTREACH). 2021. https://en.wikipedia.org/wiki/ETFA.
  2. Henriques, Bárbara J; Katrine Jentoft Olsen, Rikke; Cláudio M. Gomes; Peter Bross. ETFB gene wikipedia page - target to general audience (PUBLIC OUTREACH). 2021. https://en.wikipedia.org/wiki/ETFB.
  3. Dhaval P. Bhatt; C. Allie Mills; Kristin A. Anderson; Henriques, Bárbara J; Tania G. Lucas; Sara Francisco; Juan Liu; et al. Deglutarylation of GCDH by SIRT5 controls lysine metabolism in mice. 2020. https://www.biorxiv.org/content/10.1101/2020.06.28.176677v1.article-info.
    10.1101/2020.06.28.176677
Resumo em conferência
  1. Filipa S. Carvalho; Joana Valente Ribeiro; Botelho, Hugo M; Vilarinho, Laura; Cláudio M. Gomes; Henriques, Bárbara. "Cellular studies to evaluate mitochondria function on MADD, a rare metabolic disorder". Trabalho apresentado em FEBS OPEN BIO, 2022.
    Publicado
  2. Henriques, Bárbara; Joana V. Ribeiro; Filipa S. Carvalho; Cláudio M. Gomes. "Mechanisms of protein dysfunction in rare metabolic disorders - from protein misfolding to cellular impairment". Trabalho apresentado em FEBS OPEN BIO, 2022.
    Publicado
  3. Guilherme Gil Moreira; François Cantrelle; Quezada, Andrea; Filipa S. Carvalho; Joana Cristóvão; Urmi Sengupta; Nicha Puangmalai; et al. "A novel extracellular chaperone prevents tau aggregation and proteotoxicity". Trabalho apresentado em FEBS OPEN BIO, 2022.
    Publicado
  4. Guilherme Gil Moreira; Cláudio M. Gomes. Autor correspondente: Cláudio M. Gomes. "Tau pathological aggregation and liquid-liquid phase separation are precluded by the S100B chaperone". Trabalho apresentado em FEBS OPEN BIO, 2022.
    Publicado
  5. Joana V. Ribeiro; P. R. Magalhães; Joana F Ferreira; Faustino, Hélio; Pedro Góis; Cláudio M. Gomes; Victor, Bruno; Henriques, Bárbara. "Biochemical studies on the effect of non-enzymatic succinylation of electron transfer flavoprotein". Trabalho apresentado em FEBS OPEN BIO, 2022.
    Publicado
  6. Filipa S. Carvalho; Joana V. Ribeiro; Cláudio M. Gomes; Henriques, Bárbara J. "Mitochondria dysfunction in MADD patient- derived fibroblasts". Trabalho apresentado em Special Issue- 55TH ANNUAL SCIENTIFIC MEETING ¿ Online Event, 2021.
    Publicado
  7. Filipe E. P. Rodrigues; Cláudio M. Gomes; Miguel Machuqueiro. "Computational analysis of the interactions between the S100B extracellular chaperone and the Aß peptide". Trabalho apresentado em Virtual Workshop COMPUTER SIMULATION AND THEORY OF MACROMOLECULES 2021, 2021.
  8. Joana V. Ribeiro; Tânia G. Lucas; Peter Bross; Cláudio M. Gomes; Henriques, Bárbara J; Lucas, Tânia G.; Bross, Peter; Joana Valente Ribeiro; Tânia Gomes Lucas. "Structural and functional effects of clinical missense mutations on glutaryl-CoA dehydrogenase". Trabalho apresentado em Free Radical Biology and Medicine, 2018.
    Publicado
  9. Joana S. Cristóvão; Vanessa Morris; Isabel Cardoso; Leal, Sónia S.; Hugo M. Botelho; Christoph Göbl; Katrin Kierdorf; et al. "The neuronal S100B cytokine targeting amyloid-beta aggregation in Alzheimer's disease". Trabalho apresentado em FEBS Journal, 2017.
    Publicado
  10. Leal, Sónia S.; Joana M. Cristóvão; Cláudio M. Gomes. "Neurometals as modulators of protein aggregation in neurodegenerative diseases". Trabalho apresentado em Protein Science, 2015.
    Publicado
  11. Henriques, Bárbara J; Anderson, KA; Hirschey, MD; Cláudio M. Gomes. "Regulation of mitochondrial beta oxidation by non-enzymatic post-translational modification". Trabalho apresentado em 40th Congress of the Federation-of-European-Biochemical-Societies (FEBS) - The Biochemical Basis of Life, Berlin, 2015.
    Publicado
  12. João V. Rodrigues; Henriques, Bárbara J; R Olsen; Peter Bross; Cláudio M. Gomes. "Protein dysfunction in mitochondrial fatty acid ß oxidation accounts for oxidative stress burden". Trabalho apresentado em The Febs Journal, 2011.
    Publicado
  13. Leal, Sónia S.; Valentine, J.S.; Cláudio M. Gomes. "The effect of metal ions coupled with synaptic signaling on SOD1 aggregation events". Trabalho apresentado em 36th FEBS congress – Biochemistry for tomorrow’s medicine, Torino, 2011.
    Publicado
  14. Henriques, Bárbara J; Fisher, M.T.; Peter Bross; Cláudio M. Gomes. "Electron transfer flavoprotein polymorphism modulates protein stability as evidenced by thermal stress". 2011.
  15. Cláudio M. Gomes. "Pathogenesis mechanisms in mitochondrial ß oxidation diseases: protein misfolding, function and small molecules". Trabalho apresentado em FEBS Journal, 2011.
    Publicado
  16. Silva, M.A.; Londer, Y. Y.; Pokkuluri, P. R.; Schiffer, M.; Cláudio M. Gomes; Salgueiro, C.A.. "Thermal and Chemical Unfolding Studies in Chemotaxis heme sensors from Geobacter sulfurreducens". Trabalho apresentado em X European Biological Inorganic Chemistry Conference, Thessaloniki, 2010.
    Publicado
  17. Nascimento, C.; Hugo M. Botelho; Tavares De Almeida, I.; Cláudio M. Gomes; Paula Leandro. "Folding rescue of mild PKU mutations by chemical chaperones". Trabalho apresentado em Journal of Inherited Metabolic Disease, 2007.
    Publicado
  18. Vicente, J.B.; Cláudio M. Gomes; Wasserfallen, A.; Saraiva, L.M.; Teixeira, M.. "A diiron center in a ß-lactamase-like fold is responsible for oxygen reductase activity in the emerging family of mosaic proteins, the A-type flavoproteins". Trabalho apresentado em Journal of Inorganic Biochemistry, 2001.
    Publicado
  19. Lemos, R.S.; Cláudio M. Gomes; Santana, M.; LeGall, J.; Xavier, A.V.; Teixeira, M.. "The strict anaerobe d. gigas contains a membrane-bound oxygen respiratory chain". Trabalho apresentado em Journal of Inorganic Biochemistry, 2001.
    Publicado
  20. Bandeiras, T.M.; Cláudio M. Gomes; Teixeira, M.. "Insights into archaeal type-II NADH dehydrogenases". Trabalho apresentado em Journal of Inorganic Biochemistry, 2001.
    Publicado
  21. Cláudio M. Gomes; Vicente, J.B.; Wasserfallen, A.; Saraiva, L.M.; Teixeira, M.. "A novel two-component enzyme system from Escherichia coli composed by flavorubredoxin and its flavoprotein reductase partner". Trabalho apresentado em European Journal of Biochemistry, 2001.
    Publicado
  22. Vicente, J.B.; Cláudio M. Gomes; Wasserfallen, A.; Teixeira, M.. "A multi-domain A-type flavoprotein from Synechocystis sp. containing a fused putative reductase module". Trabalho apresentado em European Journal of Biochemistry, 2001.
    Publicado
  23. Campos, M.; Cláudio M. Gomes; Pereira, M.M.; Teixeira, M.; Moczygemba, C.; Guidry, J.; Jones, K.; Wittung-Stafshede, P.. "Hyperstability of iron-sulfur proteins: effect of structural metals and electrostatic interactions and evidence for a linear 3Fe centre during unfolding". Trabalho apresentado em European Journal of Biochemistry, 2001.
    Publicado
  24. Bandeiras, T.M.; Cláudio M. Gomes; Teixeira, M.. "Insights into type-II NADH dehydrogenases: new examples from archaea". Trabalho apresentado em European Journal of Biochemistry, 2001.
    Publicado
  25. Lemos, R.S.; Cláudio M. Gomes; Santana, M.; Legall, J.; Xavier, A.V.; Teixeira, M.. "The membrane-bound oxygen-reducing respiratory chain of the ‘strict’ anaerobe D. gigas.". Trabalho apresentado em European Journal of Biochemistry, 2001.
    Publicado
  26. Pereira, M.M.; Cláudio M. Gomes; Teixeira, M.. "Proton pathways in haem-copper oxidases". Trabalho apresentado em European Journal of Biochemistry, 2001.
    Publicado
  27. Frazão, C.; Silva, G.; Cláudio M. Gomes; Matias, P.; Coelho, R.; Sieker, L.; Macedo, S.; et al. "Dioxygen reduction in stritc anaerobes, structure of Desulfovirio gigas rubredoxin:oxygen oxidoreductase". Trabalho apresentado em European Journal of Biochemistry, 2001.
    Publicado
  28. Das, T.K.; Cláudio M. Gomes; Teixeira, M.; Rousseau, D.L.. "A model for redox-coupled proton translocation in an aa(3)-type heme-copper oxidase". Trabalho apresentado em Biophysical Journal, 2000.
    Publicado
  29. Das, T.K.; Cláudio M. Gomes; Teixeira, M.; Rousseau, D. L.. "Redox-linked deprotonation at the binuclear site of the aa(3)-type quinol oxidase from Acidianus ambivalens: Involvement of the heme a(3) formyl in proton translocation". Trabalho apresentado em Journal of Inorganic Biochemistry, 1999.
    Publicado
  30. Cláudio M. Gomes; Miguel Teixeira. "The family of A-type flavoproteins: new members and definitions of unique sequence fingerprints, in XIII International Symposium on Flavins and Flavoproteins". konstanz, 1999.
    Publicado
  31. Cláudio M. Gomes; Pereira, M. M.; Santana, M.; Teixeira, M.. "Alternative strategies in oxygenic respiration". Trabalho apresentado em Journal of Inorganic Biochemistry, 1999.
    Publicado
Tese / Dissertação
  1. Ribeiro, Maria Joana Valente. "Biochemical studies on clinical variants of Glutaryl-CoA Dehydrogenase, a mitochondrial enzyme involved in the rare disease Glutaric Aciduria type-I". Mestrado, 2018. http://hdl.handle.net/10451/35527.
  2. Moreira, Guilherme Gil da Silva Veríssimo. "Biochemistry of Tau aggregation and interactions in Alzheimer's disease". Mestrado, 2018. http://hdl.handle.net/10451/35430.
  3. Carvalho, Sofia Baptista de. "Structural and conformational effects of metal binding to the S100B cytokine". Mestrado, 2011. http://hdl.handle.net/10451/8475.
  4. Henriques, Bárbara J.. "Defective protein folding and function in metabolic disorders: studies on the mitochondrial flavoenzyme ETF". Doutoramento, 2010. http://hdl.handle.net/10362/5150.
  5. Botelho, Hugo M.. "Metal ions and protein folding: conformational and functional interplay". Doutoramento, 2010. http://hdl.handle.net/10362/5151.
  6. Leal, Sónia S.. "Protein folding, metal ions and conformational states: the case of a di-cluster ferredoxin". Doutoramento, 2010. http://hdl.handle.net/10362/3567.
  7. "Oxygen Utilisation by Procaryotes - Redox Proteins from Archaea and Anarobic Bacteria". Doutoramento, Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, 1999.

Propriedade Intelectual

Pedido provisório de patente
  1. 2022. "M13 bacteriophages displaying peptide motifs targeting amyloid-ßeta, methods and uses thereof".
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2023/03/23 The TWIN2PIPSA project at Ciências ULisboa: Twinning for strategic networking and impactful research and innovation in Biomedicine and Biotechnology Twin4Promis Kick off Meeting | Organizational Session
Biomedical Sciences Research Center "Alexander Fleming" & National Hellenic Research Foundation (Atenas, Grécia)
2023/03/23 Modulation of protein condensation and aggregation in Alzheimer's Disease Twin4Promis Kick off Meeting | Scientific Symposium
Biomedical Sciences Research Center "Alexander Fleming" & National Hellenic Research Foundation (Atenas, Grécia)
2023/03/06 Chaperone regulation of the protein condensation and aggregation continuum in Alzheimer's disease Department invited seminars
Institut Pasteur de Lille (Lille, França)
2022/12/08 Novel chaperones counteracting protein aggregation in neurodegeneration
Max Delbrück Center for Molecular Medicinene in the Helmholtz Association in Berlin (Berlim, Alemanha)
2022/10/25 Dynamic interactions and Ca-binding modulate the chaperone activity of S100B preventing tau aggregation and seeding EuroTau meeting
(Lille, França)
2022/09/21 Extracellular chaperones counteracting protein aggregation in neurodegeneration Leuven Protein Aggregation Meeting
KU Leuven - Switch Laboratory (Leuven, Bélgica)
2022/07/09 A novel extracellular chaperone prevents tau aggregation and proteotoxicity Congresso IUMBM/FEBS/PABMB 2022 – The Biochemistry Global Summit Lisbon - Molecular Medicine V - Aging
(Lisboa, Portugal)
2022/05/30 Modulators of protein aggregation and toxicity in neurodegenerative diseases Molecular Bases of Proteinopathies
University of Michigan, USA (video-conferência, Estados Unidos)
2022/02/22 The chaperone activity of S100B prevents tau aggregation and seeding 6th Ulm Meeting on “Biophysics of Amyloid Formation”
Insitute Protein Biochemistry, University Ulm (Virtual Meeting, Alemanha)
2021/10/25 The chaperone activity of S100B prevents tau aggregation and seeding EUROTAU 2021
(Lille, França)
2021/10/12 The S100B chaperone precludes formation of Tau puncta and liquid-liquid phase separation PhasAGE International Conference "Phase Transitions in Aging and Age-related Diseases
i3S - Instituto de Investigação e Inovação em Saúde da Universidade do Porto (Virtual Meeting, Portugal)
2021/09/09 Inflammatory alarmins with novel chaperone activities against protein aggregation in Alzheimer's disease Neuroscience Ireland 2021 meeting
Neuroscience Ireland (Virtual Meeting, Irlanda)
2021/06/07 Extracellular regulation of protein aggregation in Alzheimer's Disease Neurosciences Seminar series
Instituto de Medicina Molecular (IMM) (Lisboa, Portugal)
2020/02/06 S100 Proteins in Alzheimer's Disease: alarmins with novel chaperone activities Seminar at the Department of Clinical Neurosciences
University of Cambridge (Cambridge, Reino Unido)
2019/11/15 S100 alarmins as novel proteostasis players in Alzheimer's Disease EMBO Workshop on Proteostasis: From organelles to organisms
EMBO (Ericeira, Portugal)
2019/10/29 A new mechanism to inhibit amyloid aggregation in Alzheimer's Disease Seminário Ciências Research Day
Universidade de Lisboa, Faculdade de Ciências (Lisboa, Portugal)
2019/08/30 Suppression of Aß aggregation by the extracellular synaptic S100B protein ADAM8 8th Scandinavian Conference, Amyloid Diseases and Amyloid Mechanisms
(Lund, Suécia)
2019/06/11 Alzheimer's disease: protein aggregation in the brain and new inflammatory chaperones at the rescue Workshop Integrative approaches to protein folding & aggregation
Faculdade de Ciências da Universidade de Lisboa (Lisboa, Portugal)
2019/03/26 S100B protein is a calcium-tuned neuronal suppressor of amyloid-beta aggregation AD/PD 2019 - 14th International Conference on Alzheimer's & Parkinson's Diseases
(Lisbon, Portugal)
2019/03/21 S100B protein is a new inflammatory suppressor of amyloid-ß aggregation Workshop Strategies and tools for modulating pathologic protein self-assembly in proteinopathies
i3S – Instituto de Investigação e Inovação em Saúde, Universidade do Porto (Porto, Portugal)
2019/02/19 The neuronal S100B alarmin is a calcium-tuned suppressor of Aß aggregation 3rd Ulm Meeting Biophysics of Amyloid Formation
Ulm University (Ulm, Alemanha)
2019/01/25 The biochemistry of protein aggregation in Alzheimer’s Disease Chemistry & Biology Cross Talks 2019
Academia das Ciências de Lisboa (Lisbon, Portugal)
2018/12/12 Alzheimer's disease: protein misfolding in the brain and new inflammatory chaperones at the rescue Seminário CEDOC-NOVA
Faculdade de Ciências Médicas Universidade Nova de Lisboa (Lisboa, Portugal)
2018/09/21 The neuronal S100B alarmin as a calcium-tuned suppressor of Aß aggregation in Alzheimer’s disease International conference Current Challenges in Amyloid Diseases
Crowne Plaza Dead Sea hotel (Ein Bokek, Israel)
2018/06/21 Neuroinflammation meets protein aggregation: the neuronal S100B alarmin is a calcium-tuned suppressor of Aß aggregation Integrative approaches in Neurodegeneration" Workshop
Faculdade de Ciências Universidade de Lisboa (Lisbon, Portugal)
2018/05/31 Amyloids in neurodegeneration Seminar Faculty Medicine
University of Belgrade (Belgrade, Sérvia)
2017/09/18 A new role for S100B protein in amyloid-ßeta aggregation in Alzheimer’s disease Alzheimer´s Global Summit
Fundação Champalimaud (Lisbon, Portugal)
2017/06/18 Zinc as a modulator of protein folding and supramolecular assembly International Society Zinc Biology 2017 Meeting
University of Central Lancashire Cyprus Campus (Pyla, Chipre)
2017/05/24 When proteins misfold in the brain: the molecular and chemical biology of neurodegeneration Seminar Department of Chemistry and Biochemistry
Faculty of Agronomy, Mendel University (Brno, República Checa)
2017/05/02 When proteins misfold in the brain: the molecular and chemical biology of neurodegeneration Ciclo de palestras Centro Química
Departamento de Química da Universidade do Minho (Braga, Portugal)
2017/03/27 The biochemistry of protein aggregation in neuronal microenvironments: metal ions and metal-binding cytokines 4th Distalz International Workshop on Inhibition of protein-Protein Interactions in Alzheimer’s Disease and Related Proteinopathies
(Lille, França)
2016/06/29 It’s a crowd: metal ions and protein aggregation in neuronal microenvironments Simpósio Understanding the Molecular Brain in Health and Disease
Faculdade de Ciências Universidade de Lisboa (Lisbon, Portugal)
2016/04/19 Amylods in Health and Disease
Institute of Chemistry in Medicine, University of Belgrade (Belgrade, Sérvia)
2016/04/06 S100 proteins as novel metal-ion regulated molecular chaperones in neurodegeneration
Neurozentrum, Ulm University (Ulm, Alemanha)
2016/04/04 When proteins misfold in the brain: the molecular and chemical biology of neurodegeneration Seminários Colégio Mente-Cérebro
Faculdade de Medicina da Universidade de Lisboa (Lisboa, Portugal)
2015/10/09 Neurometals as modulators of protein aggregation in neurodegenerative diseases
Institute of Chemistry in Medicine, University of Belgrade (Belgrade, Sérvia)
2015/10/07 When proteins misbehave: Diseases of protein folding
School of Medicine University of Belgrade (Belgrade, Sérvia)
2015/09/28 S100 proteins as novel metal-ion regulated molecular chaperones in neurodegeneration
Karolinska Institutet, Center for Alzheimer Research (Stockholm, Suécia)
2015/07/01 When proteins misbehave: Diseases of protein folding
Instituto Nacional de Saúde Ricardo Jorge (Lisboa, Portugal)
2015/06/10 Neurometals as modulators of protein aggregation in neurodegenerative diseases 6th EuChem for Life Sciences
Reitoria UNL (Lisboa, Portugal)
2015/05/08 S100 proteins as novel metal-ion regulated molecular chaperones in neurodegeneration EMBO conference Molecular chaperones: From molecules to cells and misfolding diseases
(Heraklion, Grécia)
2015/04/28 When proteins misfold in the brain: the molecular and chemical biology of neurodegeneration First NeuroLx meeting
CEDOC (Lisbon, Portugal)
2014/11/17 When proteins misfold in the brain: the molecular and chemical biology of neurodegeneration Symposium: From genes to genious!
Instituto de Biologia Molecular e Celular (Porto, Portugal)
2014/07/08 Neuronal chemical and biological modulators of protein aggregation in neurodegenerative diseases
Institute of Biotechnology and Biomedicine Universitat Autònoma de Barcelona (Barcelona, Espanha)
2014/05/07 Small molecules at the rescue of misfolded proteins 10th Int Conference Protein Stabilisation
(Stresa, Itália)
2014/01/26 Protein misfolding and aggregation in human disease Seminário de Investigação BioSys/BioFIG
Universidade de Lisboa, Faculdade de Ciências (Lisboa, Portugal)
2013/12/02 Role of corruptive protein templating and metal ions in neurodegeneration onset and disease mechanisms 2nd Iberian Congress on Prions
(Faro, Portugal)
2013/10/10 Cross talks between amyloid-forming proteins and metal ions in neurodegeneration VIB-SWITCH
Universidad de Leuven (Leuven, Bélgica)
2013/07/15 Cross talks between amyloid-forming proteins in neurodegeneration 9th European Biophysics Congress
(Lisbon, Portugal)
2012/12/14 Protein misfolding and rare metabolic diseases: from proteins, to drugs and organisms Symposium on Rare Diseases of the metabolism
FCM/UNL (Lisbon, Portugal)
2011/12/15 Protein aggregation pathways at the synaptic millieu Congresso Nacional de Bioquímica
(Porto, Portugal)
2011/11/03 Cofactors and metabolites as potential stabilizers of mitochondrial acyl-CoA dehydrogenases Inborn Errors of Metabolism and neurodegeneration – VIII International Symposium SPDM
(Porto, Portugal)
2011/07/20 Protein deposition pathways in the unique chemical biology of the synaptic milieu
Institut Européen de Chimie et Biologie, Univiversité Bordeaux (Bordeaux, França)
2011/06/27 Metal ions and Protein aggregation pathways at the synaptic milieu Seminar Series Chemistry Department
University Torino (Torino, Itália)
2011/06/25 Pathogenesis mechanisms in mitochondrial ß oxidation diseases: protein misfolding, function and small molecules 36th FEBS Meeting
(Torino, Itália)
2011/05/18 Protein folding and structure: from fundamentals to disease
Departamento de Ciências Médicas da Universidade da Beira Interior (Covilhã, Portugal)
2011/03/28 Defective Electron Transfer Flavoprotein folding in MADD Aarhus Stress Group Seminar
Faculty of Health Sciences Aarhus University (Aarhus, Dinamarca)
2011/02/14 Protein aggregation pathways at the synaptic environment
nstitute de Chimie de Coordination, Université Paul Sabatier (Toulouse, França)
2011/01/26 Protein misfolding and function in neurodegeneration
Institute of Biomedicine CSIC Valencia, Spanish National Research Council (Valencia, Espanha)
2010/09/24 Misfolding and amyloid self-assembly of S100 proteins: novel pathways to disease?
Instituto Biologia Molecular Celular (Porto, Portugal)
2010/07/07 Iron, Frataxin and Friedreich's ataxia IV SpanishPortuguese Biophysical Congress
(Zaragoza, Espanha)
2010/06/10 Understanding defective protein folding in ß oxidation disorders: from structural biochemistry to model systems
Amsterdam Medical Center, University of Amesterdam (Amsterdam, Países Baixos)
2010/06/04 Protein misfolding and flavinylation in MADD: a molecular rationale for the effects of riboflavin supplementation 42nd European Metabolic Group Meeting
(Lisbon, Portugal)
2010/03/29 Defective Protein Folding in the cell: multiple pathways to disease Protein/Protein interaction and Protein folding Meeting
(Monte Caparica, Portugal)
2010/03/05 Protein misfolding and amyloidogenesis: multiple pathways to disease
iMED – Faculdade Farmácia Universidade de Lisboa (Lisboa, Portugal)
2009/05/23 Rescue of Folding defects in fatty acid metabolic disease EMBO-FEBS Workshop on Cellular Protein Homeostasis in disease and ageing
(Dubrovnik, Croácia)
2009/04/07 Defective protein folding in human disease: when molecular origami in the cell goes wrong Seminar Series Medical Biochemistry and biophysics department
Umea University (Umea, Suécia)
2009/02/11 Protein Misfolding and Disease Ciclo de Seminários Professor António Xavier
DQB Faculdade Ciencias, Universidade de Lisboa (Lisboa, Portugal)
2008/07/10 Protein Misfolding and Disease: frataxin misfolding and functional impairment in neurodegeneration 1st Portuguese-Spanish-British Joint Biophysics Congress
(Lisbon, Portugal)
2008/03/12 Protein misfolding and aggregation in neurodegenerative diseases Lisbon Area Neuroscience Meeting
Instituto Gulbenkian de Ciência (Oeiras, Portugal)
2007/07/09 Conformational destabilisation of human frataxin variants in the context of the neurodegenerative disorder Friedreich´s Ataxia EMBO-FEBS Workshop on Chaperones in Normal & Aberrant Protein Folding, Aging & Cancer
(Tomar, Portugal)
2007/06/09 Biophysical studies of metal binding to SOD1 ICOSA 8 - International Consortium on Superoxide Dismutase and Amyotrophic Lateral Sclerosis
(Umea, Suécia)
2007/02/02 Protein folding destabilization and disease phenotypes: the example of Frataxin and Friedreich´s ataxia Workshop on Proteins in Health and Disease: from structure to function
Faculdade Farmácia Universidade de Lisboa (Lisbon, Portugal)
2007/01/24 Protein Misfolding and Human Disease
Dep Química Faculdade de Ciência e Tecnologia UNL (Monte Caparica, Portugal)
2006/11/08 Protein misfolding and Disease A one day workshop on protein science
Complexo interdisciplinar Universidade de Lisboa (Lisbon, Portugal)
2006/09/24 Misfolding and Conformational destabilization of frataxin clinical variants: implications on the pathology of the neurodegenerative disease Friedreich´s ataxia VI Ibero-American Congress of Biophysics
(Madrid, Espanha)
2006/07/01 Metals and Protein Folding: Conformational stability of iron-sulfur proteins 8th European Bioinorganic Chemistry Conference
(Aveiro, Portugal)
2005/06/27 Protein Folding, Metals and Disease
Department of Biochemical Sciences, University of Rome La Sapienza (Rome, Itália)
2005/02/10 Hyperstable iron sulfur proteins from thermophiles
National Institute Medical Research, Medical Research Council (London, Reino Unido)
2005/01/16 Protein Folding and Stability Scientific Conferences at Noon seminar
Instituto de Tecnologia Química e Biológica (Oeiras, Portugal)
2001/10/23 Elucidating Structural and Functional Features in Metalloproteins using Bioinformatics tools IV Gulbenkian Autumn Meeting on Theroretical and computational Biology
(Oeiras, Portugal)
2001/03/08 A novel scenario for the evolution of heme copper oxidases IUBMB Workshop on Protonmotive Heme-Copper Oxidases
(Bari, Itália)
1999/09/04 The emerging family of A-type flavoproteins: Desulfovibrio gigas rubredoxin:oxygen oxidoreductase as a case study 13th International congress on flavins and flavoproteins
(Konstanz, Alemanha)
1999/05 Oxygen utilisation and scavenging mechanisms in anaerobic organisms of the Desulfovibrio genus Metals in Biological systems, Bioinorganic Society meeting
(Tomar, Portugal)
1998/11 Novel antioxidant proteins from anaerobic bacteria and hyperthermophilic archaea Extremophiles as cell factories Novo Nordisk meeting
(Copenhagen, Dinamarca)
1998/07 The oxygen utilising pathway of the anaerobe Desulfovibrio gigas European Bioinorganic Chemistry Conference
(Sevilla, Espanha)
1998/07 The archaeon Acidianus ambivalens expresses two distinct succinate/fumarate oxidoreductases depending on the growth mode in respect to oxygen TMR summer school Spectroscopy and Engineering of metalloproteins
ITQB (Oeiras, Portugal)
1998/06 The novel succinate dehydrogenase/fumarate reductase complexes from Acidianus ambivalens 10th European Bioenergetics Conference
(Goteborg, Suécia)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2021/09 - Atual Brain S100 proteins as a toolbox of novel chaperones to prevent amyloid aggregation and toxicity in Neurodegeneration (PhD)
Orientador de António J. Figueira
Bioquímica (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal
2021/09 - Atual Extracellular regulation of Tau aggregation and amyloid cross-interactions in Alzheimer's Disease
Orientador de Daniela Freitas
 Biologia Molecular e Genética (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2021/09 - Atual Understanding the Molecular Basis of Mitochondrial Neurological Diseases - Studies on Aminoacyl-tRNA Synthetase Disease Variants
Orientador de Beatriz Rasgado Lopes
 Bioquímica (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2020/09 - Atual The calcium-binding protein S100B as a novel chaperone preventing Tau aggregation in Alzheimer's disease (PhD)
Orientador de Guilherme G. Moreira
 Bioquímica (Outra)
Universidade de Lisboa Faculdade de Ciências, Portugal
2020 - Atual Unravelling the pathological mechanisms of rare metabolic disorders - from protein misfolding to mitochondrial dysfunction (PhD)
Orientador de Maria Joana Ribeiro
 Bioquímica (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal
2018 - Atual The role of secondary modification of S100B in protein aggregation and its influence on Alzheimer´s disease pathology (PhD) - Programa Doutoral BioSys (PhD)
Orientador de Romina Coelho
 Biologia (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal
2020/09/08 - 2022/02/14 Mechanisms of protein dysfunction in aminoacyl-tRNA synthetase related to neurological diseases
Orientador de Diogo Miguel Fernandes Meireles Ferreira
 Bioquímica (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2021 - 2021 Relevance of NLRP3 inflammasome in A1 astrocytes - impact of AB-induced toxicity
Coorientador
 Biologia Molecular e Genética (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2021 - 2021 Organotypic Brain Slices Cultures as a model to study supressors of amyloid-beta Toxicity Relevant in Alzheimer´s Disease
Orientador
 Bioquímica (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2021 - 2021 Molecular studies of alpha-synuclein aggregation
Coorientador
 Bioquímica (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2021 - 2021 Mecanismos e regulação da formação amilóide no contexto da doença de Alzheimer
Orientador
 Bioquímica (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2021 - 2021 Study of the interaction between the amyloid B peptide and the S100B protein using computational techniques
Orientador
 Bioquímica (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2021 - 2021 Insulin-Degrading Enzyme as a suppressor of alfa-synuclein pathogenesis
Coorientador
 Bioquímica (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2021 - 2021 The impact of BDNF receptor cleavage in Alzheimer´s disease-associated Neuroinflammation
Coorientador
 Bioquímica (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2020 - 2021 Single-Domain Antibodies targeting S100B as tools in Alzheimer´s disease
Orientador de Margarida Candeias Simões
 Bioquímica (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2020 - 2020 Blood-brain barrier: role in brain metastasization of breast cancer
Coorientador
 Biologia Molecular e Genética (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2020 - 2020 Biochemical characterization of a key cytocrome in respiratory electron transfer pathways from geobacter sulfurreducens
Coorientador
 Bioquímica (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2020 - 2020 Chaperone activity of neuronal S100 proteins
Orientador
 Bioquímica (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2019 - 2020 Molecular studies of alfa-synulcein aggregation (MSc)
Coorientador
 Bioquímica (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2019 - 2019 Vectored immunoprophylaxis to produce anti-BACE1 nanobodies for treatment of Alzheimer’s disease
Coorientador
 Biologia Molecular e Genética (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2019 - 2019 Studies on the role of calprotectin as a mediator of iron-induced inflammation with implications in Parkinson´s disease
Orientador
 Biologia Molecular e Genética (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2018 - 2019 Unraveling the pathological mechanisms of rare metabolic disorders – from protein misfolding to mitochondrial dysfunction (MSc)
Coorientador
 Doutoramento Bioquímica FCUL (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal
2018 - 2018 Biochemistry of Tau aggregation and interactions in Alzheimer´s disease
Orientador
 Bioquímica (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2017 - 2018 Exploring protein-protein interactions and cell mechanics with Atomic Force Microscopy (Post-Doc)
Orientador
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
2017 - 2018 Biochemical studies on clinical variants of Glutaryl-CoA Dehydrogenase, a mitochondrial enzyme involved in the rare disease Glutaric Aciduria type-I (MSc)
Coorientador
 Bioquímica (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2015 - 2018 A novel role of S100B in neuronal trace metal homeostasis associated with dysregulation of the autism-associated SHANK pathway (PhD)
Coorientador
Universität Ulm Medizinische Fakultät, Alemanha
2013 - 2018 Protein misfolding in mitochondrial ß-oxidation disorders (Post-Doc)
Orientador
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
2017 - 2017 S100 Proteins as novel modifiers of proteostasis in pathophysiological states (PhD)
Orientador
 Biologia (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal
2016 - 2017 Modulation of the formation and structural diversity of amyloids (Post-Doc)
Orientador
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
2016 - 2016 The calcium binding SIOOB protein as a new modulator of the Amyloid-beta peptide aggregation (PhD)
Orientador
 Bioquímica (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal
2016 - 2016 Study of the self-assembly of the pro-inflammatory S100A9 protein driven by metal ion binding
Orientador
 Bioquímica (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2015 - 2016 Agregação e formação de amiloides por proteínas neuroinflamatórias S100A8 e S100A9 e implicações em processos neurodegenerativos (MSc)
Orientador
 Bioquímica (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2009 - 2016 Misfolding and aggregation of Cu/Zn superoxide dismutase (Post-Doc)
Orientador
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
2015 - 2015 Protein misfolding and cellular responses in metabolic disorders
Orientador
 Bioquímica (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal
2011 - 2012 A agregação proteica em processos neurodegenerativos: Mecanismos de agregação da SOD1 no contexto da ELA (MSc)
Orientador
 Biotecnologia (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2007 - 2012 Protein folding studies and role of post-translational modifications in human disease (Post-Doc)
Orientador
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2005 - 2012 Protein stability in a proteomic perspective (PhD)
Orientador
 Bioquímica (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2010 - 2011 Aspectos Moleculares da Neurodegeneração na Esclerose Lateral Amiotrófica (MSc)
Orientador
 Genética Molecular e Biomedicina (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2010 - 2011 Estudos de folding e efeito de chaperões químicos e moleculares em proteínas envolvidas na ß-oxidação de ácidos gordos (MSc)
Orientador
 Bioquímica Estrutural e Funcional (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2010 - 2011 Structural and conformational effects of metal binding to the S100B cytokine (MSc)
Orientador
 Bioquímica (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2009 - 2010 Drosophila as a model to study fatty acid metabolic disorders (Post-Doc)
Orientador
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2006 - 2010 Metal Ions and Protein Folding - Conformational and Functional Interplay (PhD)
Orientador
 Bioquímica (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2006 - 2010 Defective protein folding and function in metabolic disorders: studies on mitochondrial flavoenzyme ETF (PhD)
Orientador
 Bioquímica (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2006 - 2010 Protein folding and disease: the mitochondrial protein frataxin (PhD)
Orientador
 Bioquímica (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2007 - 2008 Protein Folding and Evolution: Computational and in vitro Studies (Post-Doc)
Orientador
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2004 - 2008 Protein Folding, metal ions and conformational states: the case of a di-cluster ferredoxin (PhD)
Orientador
 Bioquímica (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2005/09 - 2006/09 Pesquisa, Identificação e Caracterização de Proteínas Hiperestáveis no Proteoma Solúvel da Archaea Hipertermofílica Sulfurisphaera sp. (BSc)
Orientador
 Bioquímica (Licenciatura/Bacharelato)
Universidade de Lisboa Faculdade de Ciências, Portugal
2005/11 - 2006 Caracterização da estabilidade conformacional de uma rubredoxina hipertermófila (BSc)
Orientador
 Bioquímica (Licenciatura/Bacharelato)
Universidade de Lisboa Faculdade de Ciências, Portugal
2005/11 - 2006 Estabilidade da SOR, uma proteína oligomérica (BSc)
Orientador
 Química Aplicada (Licenciatura/Bacharelato)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2003 - 2004 Comportamento dos centros ferro-enxofre durante a desnaturação alcalina da ferredoxina do termófilo Acidianus ambivalens (MSc)
Orientador
 Bioquímica (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2003 - 2004 Caracterização da estabilidade conformacional da frataxina, a proteína responsável pela ataxia de Friedreich (BSc)
Orientador
 Bioquímica (Licenciatura/Bacharelato)
Universidade de Lisboa Faculdade de Ciências, Portugal
2002 - 2003 Estudos de estabilidade em metalloproteínas de hipertermófilos (BSc)
Orientador
 Química Aplicada (Licenciatura/Bacharelato)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
1999 - 2000 Caracterização de NADH desidrogenase do tipo II do archeon termoacidófilo Acidianus ambivalens (BSc)
Orientador
 Química Aplicada (Licenciatura/Bacharelato)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
1999 - 2000 Caracterização molecular e espectroscópica de uma nova cadeia de transporte electrónico em Escherichia coli (BSc)
Orientador
 Química Aplicada (Licenciatura/Bacharelato)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2016/06/29 - Atual Understanding the Molecular Brain in Health and Disease - Chair: C.M. Gomes, Faculdade de Ciências da Universidade de Lisboa (2016/06/29)
Congresso (Outra)
 Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal
2019 - 2020 Masterclass Seminars series of the Masters in Biochemistry (2019 - 2020)
Seminário (Coorganizador)
 Universidade de Lisboa Faculdade de Ciências, Portugal
2019/06/11 - 2019/06/12 Workshop on Integrative approaches to protein folding & aggregation - Session Chair (2019/06/11 - 2019/06/12)
Oficina (workshop) (Outra)
 Universidade de Lisboa Faculdade de Ciências, Portugal
2018/09/02 - 2018/09/06 Current Challenges in Amyloid Diseases - Chair Session ‘Metals and amyloid aggregation’ (2018/09/02 - 2018/09/06)
Conferência (Outra)
 Israel Science Foundation, Israel
2017/06/18 - 2017/06/22 ISZB 2017 Meeting – International Society Zinc Biology - Chair Symposium ‘Zinc proteins: Folding, structure and function’ (2017/06/18 - 2017/06/22)
Simpósio (Outra)
 University of Central Lancashire - Cyprus Campus, Chipre
2013/07/13 - 2013/07/17 9th European Biophysics Congress - Chair Session ‘Intrinsically Disordered Proteins’; Chairs: C. Gomes and Y. Levy (2013/07/13 - 2013/07/17)
Conferência (Outra)
2011/09/22 - 2011/09/30 NMR applications in Protein Research: Interbio International Summer School on structural Biology Org: M.Matzapetakis (Chair), C.M. Gomes, P. Fernandes, C. Oliveira, A. Sanchez, M. Teixeira (2011/09/22 - 2011/09/30)
Conferência (Membro da Comissão Organizadora)
 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2011/05/05 - 2011/05/07 Interbio Symposium Frontiers in Protein Research - Organizers: C. Gomes, M. Teixeira, A. Sanchez, A. Veiga, L. Conceição (2011/05/05 - 2011/05/07)
Simpósio (Membro da Comissão Organizadora)
 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2010/07/07 - 2010/07/10 IV Spanish Portuguese Biophysical Congress - Chair Symposium 'Protein stability, folding and dynamics'; Chairs: CM Gomes and M. Menéndez (2010/07/07 - 2010/07/10)
Congresso (Outra)
2010/04/13 - 2010/04/13 Frontiers in Chemical Biology - One day symposium on collaborative research between Interbio partners Org: C.M. Gomes, M. Teixeira and J.J. Toulmé (Chairs) (2010/04/13 - 2010/04/13)
Simpósio (Membro da Comissão Organizadora)
 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2009/03/19 - 2009/03/19 Protein Folding Diseases: from metabolic disorders to neurodegeneration - One day international workshop Org: C.M. Gomes (chair), B. Henriques, J. Rodrigues, (2009/03/19 - 2009/03/19)
Oficina (workshop) (Membro da Comissão Organizadora)
 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2002/10/04 - 2002/10/06 Bioenergetics: the Cellular Power Plants - 4th Short course of the Portuguese Biophysical Society Org: M. Teixeira, M.M. Pereira, C.M. Gomes, R.O. Louro, M. Castanho, C.M. Soares, M. Prieto. (2002/10/04 - 2002/10/06)
Conferência (Membro da Comissão Organizadora)
 Sociedade Portuguesa de Biofísica, Portugal
2001/06/28 - 2001/06/30 Protein structure-function, trafficking and signaling - FEBS Forum of Young Scientists: Satellite meeting of the 27th FEBS/PABMB Meeting. Org: J Costa (Chair), CM Gomes, M Archer, A Henriques, S Oliveira. (2001/06/28 - 2001/06/30)
Encontro (Membro da Comissão Organizadora)
 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2018/04/22 - 2018/04/22 Alzheimer's disease: when protein misfold in the brain
Encontro
 BioSAM - Biological Sciences Annual Meeting – Encontro do Núcleo Estudantes de Biologia FCUL
Universidade de Lisboa Faculdade de Ciências, Portugal
2017/07/03 - 2017/07/05 When proteins misfold in the brain - Sessão Neurociências - Saúde, Investigação Clínica e de Translação
Encontro
 Encontro Ciência 2017
Governo da República Portuguesa Ministério da Ciência Tecnologia e Ensino Superior, Portugal
2016/04/28 - 2016/04/28 SOD1 misfolding and aggregation in ALS pathogenesis
Simpósio
 Simpósio Esclerose Lateral Amiotrófica (ELA): Ciência e Sociedade
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015/06/23 - 2015/06/23 Insultos proteicos e disfunção sináptica no cérebro em envelhecimento
Encontro
 Palestra na Conferência Envelhecimento: Pensar o Futuro Hoje

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2022/06/02 Modulation of mechanisms driving TTR amyloidogenesis: from tetramer destabilization to TTR proteolysis
Arguente
 Carla Bezerra (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/03/08 Biophysical analysis of Alzheimer’s amyloid-ß peptide assembly and clearance pathways
Arguente
 José Leite (Doutoramento)
Universidade do Porto, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021/10/30 Effects of system complexity on protein aggregation in neurodegeneration
Arguente principal
 Michele Sanguanini (Doutoramento)
University of Cambridge, Reino Unido
2021/02/24 Impact of NLRP3 Inflammasome Inhibition on a Model of Aß-Induced Toxicity
Arguente principal
 Diogo André Mendonça Dias (Mestrado)
Universidade de Lisboa Faculdade de Medicina, Portugal
2021/02/21 Effects of system complexity on protein aggregation in neurodegeneration
Arguente principal
 Michele Sanguanini (Doutoramento)
University of Cambridge Department of Chemistry, Reino Unido
2019 Targeting protein aggregation during cancer development
Arguente principal
 Evelyne Naus (Doutoramento)
Doctoral School of Biomedical Sciences, Katholic University Leuven, Bélgica
2018/12/07 A novel role of S100B in neuronal trace metal homeostasis associated with dysregulation of the autism-associated SHANK pathway
Arguente
 Simone Hagmeyer (Doutoramento)
International Graduate School in Molecular Medicine University of Ulm, Portugal
2018/11/13 Role of PKD1 and PKD2 on ion currents in renal epithelial cells
Presidente do júri
 Filipe Saúde (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2018/10/15 Study on the regulation of the expression of alternative protein isoforms involved in carcinogenesis
Presidente do júri
 Bruna Pereira (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2018/10/12 Role of Post-translational Modifications on the Oligomerization, Aggregation and Toxicity of Mutant Huntingtin
Arguente
 Joana Branco dos Santos (Doutoramento)
Universidade de Lisboa Faculdade de Medicina, Portugal
2018/09/12 Influence of histone octamer core distortion on nucleosome thermal mobility
Presidente do júri
 Alexandre Cirilo (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2018/04/24 Biological activity and functions of the capsid protein of Zika virus and related flaviviruses
Presidente do júri
 André Nascimento (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2018/03 The mechanism of action of Clioquinol for the treatment of Alzheimer’s disease
Arguente principal
 Yifat Biran (Doutoramento)
The Florey Institute of Neuroscience and Mental Health, Faculty of Medicine, Dentistry and Health Sciences of the University of Melbourne, Austrália
2017/01/06 Illuminating the Dark Proteome
Arguente
 Nélson Perdigão (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2016/11/28 Characterization of Hydroxymethylbilane Synthase and Pharmacological Chaperone Treatment for Acute Intermittent Porphyria
Arguente principal
 Helene Bustad Johannessen (Doutoramento)
Faculty of Medicine and Dentistry, University of Bergen, Noruega
2015/07/30 Analysis of CFTR mutants in epithelial Cells/tissues and testing of CFTR-repairing therapies
Arguente principal
 Inna Uliyakina (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal
2015/01/23 Actin cytoskeleton carbonylation in human T-lymphocytes: a role in cellular senescence
Arguente principal
 José Pedro Castro (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2014/11/11 Alpha-synuclein and tau: dangerous liaisons
Arguente principal
 Gianmario Ciaccioli (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal
2014/01/31 Kinetics and energetics of fundamental events in peptide and protein (un)folding
Arguente principal
 Catarina de Jesus (Doutoramento)
Universidade de Coimbra, Portugal
2013/06/14 Phenotypic consequences of genome mistranslation in Candida albicans
Arguente principal
 João Simões (Doutoramento)
Universidade de Aveiro, Portugal
2013/02/25 Regulating Proteostasis by a Chemical Genetics Approach
Arguente principal
 Mario Neto (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal
2012/12/17 Interactions des ions métalliques avec des forms tronquées du peptide amyloide-ß liées à la maladie d’Alzheimer
Arguente principal
 Bruno Aliès (Doutoramento)
Université Toulouse III Paul Sabatier, França
2012/07/14 Neural mechanisms of stimulus generalization in auditory fear conditioning
Arguente
 Raquel A.G. Antunes (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2012/07/03 Precious transition metals: The importance of Zn, Mn and Cu for the human pathogen Enterococcus faecalis
Arguente
 Marta Abrantes (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2012/01/20 Effect of sucrose on protein stability and fibrillation of Prion & S6 protein
Arguente principal
 Nídia Infante (Doutoramento)
Universidade do Algarve, Portugal
2012/01/09 Molecular pathways of NAD(P)H Dehydrogenases in neurospora crassa Mitochondria development
Arguente principal
 Patrícia Carneiro (Doutoramento)
Universidade do Porto, Portugal
2010/07/23 Impact of the UPR on the expression of relevant genes for cellular iron metabolism
Arguente
 Susana Oliveira (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2010/05/24 Methylglyoxal effects on protein aggregation and amyloid formation
Arguente principal
 Luís Oliveira (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal
2010/04/22 Interaction studies between biocompatible polymers and Aß peptides.
Arguente principal
 Ana Saraiva (Doutoramento)
Universidade do Porto Faculdade de Engenharia, Portugal
2009/12/14 Amyotrophic lateral sclerosis: mammalian cell models, copper-zinc superoxide dismutase and biological characteristics
Arguente principal
 Catarina Gomes (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2009/12/14 The neuronal L1 cell adhesion molecule: production, characterization and biological role
Arguente
 Ricardo Gouveia (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2008/11/21 p53, a novel molecular target of ursodeoxycholic acid in modulating hepatocyte apoptosis
Arguente
 Joana Amaral (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2008/02/07 Estudos estabilidade de diferentes formas da Fenilalanina hidroxilase
Arguente principal
 Cátia Nascimento (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2007/12/07 Epithelial Cells from Lung: Production, Cultivation and Characterization – Usage for Validation of Compounds Efficacy in Rescuing Mutant CFTR
Arguente
 Marta Palma (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2007/04/24 Protein Stabilization – the effect of trehalose and adsorption onto polymeric microspheres on cutinase stability
Arguente principal
 Ricardo Baptista (Doutoramento)
Universidade Técnica de Lisboa, Portugal
2007/03/09 Structure Function relationships of metalloproteins involved in oxygen and nitric oxide metabolism
Arguente principal
 Francesca Scandurra (Doutoramento)
Università degli Studi di Roma La Sapienza, Itália

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2021/07 - Atual International Journal of Molecular Sciences - Editorial Board Member Section 'Biochemistry' (1422-0067) MDPI
2019 - Atual Frontiers in Molecular Neuroscience - Associate Editor (1662-5099) Frontiers Media SA
2016 - Atual Frontiers Neuroscience (Neurodegeneration) - Associate Editor
2013 - Atual Scientific Reports (2045-2322) Springer Science and Business Media LLC
2012 - Atual PLoS ONE (1932-6203) Public Library of Science
2011 - 2021/05 Frontiers in Physiology (1664-042X) Frontiers Media SA
2012 - 2020/08 Current Topics in Medicinal Chemistry (1568-0266) Bentham Science
2015 - 2017 Biochemistry and Biophysics Reports - Associate Editor (2405-5808) Elsevier
2010 - 2015 Bioinorganic Chemistry and Applications (1687-479X) Hindawi Limited
2012 - 2014 Dataset Papers in Biology (2090-9764) Hindawi (Datasets International)

Entrevista (jornal / revista)

Descrição da atividade Jornal / Forum
2022/11/14 Newly funded Twinning project on protein biophysics will support innovation in biomedicine and biotechnology Eurekalert!
2021/11/01 Nova função de proteína do cérebro atrasa causas de demências neurodegenerativas - Descoberta liderada por professor da Ciências ULisboa publicada na Nature Communications Notícias FCUL, 15-01-2021
2021/11/01 Há uma proteína que ajuda a travar o avanço da demência: equipa portuguesa liderou estudo Observador
2021/01/15 Cláudio Gomes: "A promoção e reconhecimento da qualidade da investigação científica tem um impacto muito positivo dentro e fora da própria Universidade" Notícias FCUL, 15-01-2021 Notícias FCUL, 15-01-2021
2018/07/24 Entrevista - Cláudio M. Gomes. 'Ainda há muito por saber em relação à doença de Alzheimer' Jornal Sol
2018/06/30 "Equipa liderada por português descobre como atrasar uma das causas de Alzheimer" TSF
2018/06/26 Equipa liderada por português descobre proteína do cérebro que protege de Alzheimer Observador, 29/06/2018 Observador
2000/11/30 Usam extremófilos para estudar a vida Jornal de Notícias
2000/11/28 Nature revela importante descoberta de um grupo de cientistas portugueses Diário de Notícias

Entrevista / Programa (rádio / tv)

Programa Tema
2021/11/03 - Atual Reportagem - Investigação liderada por português descobre que proteína cerebral atrasa "origem" de Alzheimer Reportagem TVI Jornal da Uma
2012/06/20 - 2012/06/20 'Com Ciência' RTP2 Novo modelo para uma doença rara
2008/09/25 - 2008/09/25 Telejornal, RTP1 Noite dos Investigadores
2008/09/23 - 2008/09/23 Prova Oral Antena 3 Noite Europeia dos Investigadores

Membro de associação

Nome da associação Tipo de participação
2009 - Atual Sociedade Portuguesa de Biofísica
2008 - Atual Sociedade Portuguesa de Bioquímica
2008 - Atual Biochemical Society
2007 - Atual Sociedade Portuguesa de Química
2007 - Atual Society for Biological Inorganic Chemistry
2007 - Atual Protein Society

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2022 - Atual Project evaluator for international scientific agencies - Israel Science Foundation Binational Science Foundation, Israel
2022 - Atual Project evaluator for international scientific agencies - Fonds de la Recherche Scientifique - FNRS Fonds de la Recherche Scientific, Bélgica
2021 - Atual Project evaluator for international scientific agencies - National Science Centre, Poland Narodowe Centrum Nauki, Polónia
2020 - 2020 Project evaluator for international scientific agencies - Israel Science Foundation Israel Science Foundation, Israel
2019 - 2019 Project evaluator for international scientific agencies - Fund for Scientific Research – FNRS, Bélgica - Evaluator FNRS 2019 Call equipment credit
2018 - 2018 Project evaluator for international scientific agencies - Research Foundation Flanders – FWO, Bélgica
2018 - 2018 Project evaluator for international scientific agencies - Fund for Scientific Research – FNRS, Bélgica - Evaluator FNRS 2018 Generet Award for Rare Diseases 2018 & Evaluator FNRS 2018 Call Grants and fellowships
2017 - 2017 Project evaluator for international organizations - Royal Swedish Academy Sciences, Suécia - Evaluator Wallenberg Fellows
2017 - 2017 Stanford Synchrotron Radiation Lightsource, SSRL, USA – Projects Evaluator
2017 - 2017 FCT - Avaliador do painel de avaliação para a cooperação Bilateral 2016 Fundação para a Ciência e a Tecnologia, Portugal
2014 - 2017 Comitee Short Term Scientific Training COST Action ZincNet TD1304
2016 - 2016 Project evaluator for international scientific agencies - Agence Nationale de Recherche, ANR França - ANR 16 Comité CES11 Biochimie, Biophysique, Biologie moléculaire et structurale & ANR 16 Comité CE32 Sciences de la vie
2016 - 2016 Wallenberg fellows nominations - Chalmers University of Technology, Sweden Chalmers tekniska högskola, Suécia
2015 - 2015 Project evaluator for international organizations - European Commission - Horizon 2020-PHC14-2015 - Evaluator
2015 - 2015 Investigation Projects - University of Rome La Sapienza, Itália Università degli Studi di Roma La Sapienza, Itália
2015 - 2015 Avaliador iMed Conference - Fundação AstraZeneca Innovate Competition Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2014 - 2014 Project evaluator for international organizations - Italian Telethon Foundation, Itália - Evaluator
2013 - 2013 Project evaluator for international scientific agencies - ANR Comité Blanc SVSE5 Physics, Life chemistry and biotechnological innovations
2013 - 2013 Project evaluator for international scientific agencies - Israel Science Foundation, Israel
2013 - 2013 Project evaluator for international organizations - Royal Swedish Academy Sciences, Suécia - Evaluator Wallenberg Fellows
2013 - 2013 Project evaluator for international organizations - Institute Pasteur-Fondazione Cenci Bolognetti, Itália - Evaluator
2013 - 2013 Industrial Research Fund FWO - University of Leuven, Belgium Katholieke Universiteit Leuven - Campus Brussel, Bélgica
2012 - 2012 Project evaluator for international scientific agencies - Romanian National Research Council, Roménia
2012 - 2012 Project evaluator for international organizations - Royal Swedish Academy Sciences, Suécia - Wallenberg Academy Fellows
2012 - 2012 Project evaluator for international organizations - Research Foundation Flanders, Bélgica - Evaluator
2012 - 2012 Projectos Conselho de Investigação - University of Leuven, Belgium Katholieke Universiteit Leuven - Campus Brussel, Bélgica
2010 - 2010 Project evaluator for international organizations - Prinses Beatrix Fonds, Holanda - Evaluator
2010 - 2010 Project evaluator for international organizations - Fondazione Cariplo Milano, Itália - Evaluator Biomedicine
2008 - 2008 Project evaluator for international organizations - Smithsonian Institution, EUA - Evaluator Indo-US S&T Forum

Tutoria

Tópico Nome do aluno
2019/09 - 2019/12 Biochemical studies on amyloid beta Catarina Matos
2019/10/07 - 2019/11/01 Expression, purification and biochemical analysis of the Alzheimer’s disease-associated amyloid ß-peptide Cindy Blom
2019/10/07 - 2019/11/01 Expression, purification and biochemical analysis of the Alzheimer's disease-associated amyloid ß-peptide Myrrhe Venema
2019/01 - 2019/08 Purification and enzymology of mitochondrial dehydrogenases Mariana Almeida
2019/01 - 2019/07 Expression and purification of amyloidogenic human proteins Margarida Pedro
2018/10 - 2018/11 Biochemistry and Folding studies on the protein alpha-synuclein Jann-Louis Hau
2018 - 2018 Biochemical and spectroscopic analysis of the interaction of the inhibitor pentamidine with the S100B protein Ana Marta Capaz
2017/06 - 2017/07 Protein post-translational modifications Sophie Nguyen
2017/02 - 2017/02 Investigation of S100B aggregation states under different culture conditions in vitro Simone Hagmeyer
2017/01 - 2017/02 Impacto de modificações pós-traducionais não-enzimáticas em doenças do metabolismo: estudo da proteína ETF Lívia Maebuti
2016/01 - 2016/05 alpha-synulein purification and aggregation kinetics in Parkinson’s Disease Jana Vrints
2016/01 - 2016/02 Aspirina como modelo para acetilação e agregação da SOD1: relevância para a pesquisa translacional com Esclerose Lateral Amiotrófica Daniel Netto
2011/04 - 2011/06 Novel findings in amino acid position 163 mutants of human ETHE1 protein leading to Ethylmalonic Encephalopathy Jane B. Frederiksen
2010 - 2010 Role of Disulfide and of a salt bridge in the stability of the soluble Rieske Ferredoxin protein type-2 Francesco Barbero
Distinções

Prémio

2021 Honorable Mention - Scientific Awards University of Lisbon - Panel: Biomedical Sciences
Universidade de Lisboa, Portugal
2021 Labcollector Scientific Award 2021
AgileBio SARL, França
2019 Honorable Mention - Scientific Awards University of Lisbon - Panel: Biology. Biological Engineering, Biochemistry and Biotechnology
Universidade de Lisboa, Portugal
2011 Terry Fox Research Award
Liga Portuguesa Contra o Cancro, Portugal
2000 Gulbenkian Program for Stimulating Research
Fundação Calouste Gulbenkian, Portugal

Outra distinção

2020 PhD Thesis Excellence Award - Life Sciences and Health (To PhD student J. Cristóvão)
FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal