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Raquel Boia (RB) is a researcher at the Coimbra Institute for Clinical and Biomedical Research (iCBR) of the Faculty of Medicine of University of Coimbra (FMUC), which is part of CIBB (Center for Innovative Biomedicine and Biotechnology), University of Coimbra (UC). Raquel Boia is graduated in Biochemistry and concluded her MSc degree in Biochemistry, in 2013, aiming to unravel the potential of microglia-mediated neuroinflammation control as a therapeutic strategy for retinal neuroprotection in experimental models of glaucoma. Then, she was a research fellow in a FCT-funded project (PTDC/BIM-MEC/0913/2012). Afterward, she was granted a PhD fellowship (FCT, PD/BD/114115/2015) in the Inter-University Doctoral Program in Ageing and Chronic Diseases of UC. She studied the therapeutic benefits of the adenosine A3 receptor (A3R) agonist to retinal ganglion cells neuroprotection, identifying a potential treatment for vision loss in glaucoma. These years’ work culminated in several publications, in which her publication Boia et al, 2022, J Control Release, IF: 11.467 was selected to be featured in the cover, March 2022, after Editor-in-chief invitation, and it was identified as a Top 1-5% published scientific paper for UC. RB research outputs include 24 publications in leading peer-reviewed journals (7 as first author), with an average IF of 5.7, h-index of 16 and more than 820 citations (as of February 2024). All of her contributions to this scientific field culminated in the award in the Innovators category by The IAPB - Eye Health Hero Programme in 2021, which is a recognition based on her contribution in aiding vision and restoring sight all around the globe as an Innovator. Moreover, she was awarded the Prize L'Oréal Portugal Medals of Honor for Women in Science 2022, with the project “A new therapeutic approach to leverage vision restoration in glaucoma”. RB has been involved in scientific projects as, i) PI: L'Oréal Portugal Medals of Honor for Women in Science 2022; ii) TEAM MEMBER: 8 grants (3 awarded by FCT - 1 is an ongoing project; 1 funded by Bayer HealthCare; 3 funded by the FMUC and 1 funded by Manuel Rui Azinhais Nabeiro, Lda). The activities of academic supervision and guidance are reflected in, i) SUPERVISION: 4 master students (3 ongoing), 11 undergraduate students, 1 scholarship holder, 2 Summer Internships at UC and 4 elementary school students from summer internship program “Ciência Viva no Laboratório”; ii) GUIDANCE: 1 international Post-Doc during the stay in Portugal, 6 PhD students during Lab rotations, 5 master students, 10 undergraduate students and 1 scholarship holder. Her teaching activities are reflected in: laboratorial tutor of the Advanced Course in Vision Sciences from the PhD program in Health Sciences and of the Course of Sciences in Laboratory Animals, lectures in the Advanced Course in Vision Sciences of the PhD Programme in Health Sciences of FMUC; main examiner in a jury of Bsc degree and Msc thesis. Moreover, RB contributions are also reflected in 15 published abstracts from scientific meetings and 1 proceeding of international conference, 36 oral communications (12 as invited/presenting author), 80 poster presentations (as author/co-author). RB has also been participating as guest editor in several special issues, and to note the one from Frontiers in Neuroscience entitled “Molecular and cellular players of axonal regeneration in injured CNS”. She acted as a reviewer for Acta Biomaterialia; Molecular Neurobiology; Biomedicine Hub; Cells; IJMS; Journal of Clinical Medicine; Journal of Ophthalmology and Nutrients. RB has been actively participating in outreach science activities: World Sight Day, Brain Awareness Week and European Researchers Night. She is also team member of a science communication project Talk Neuro to Me (“Fala-me Neuro” in Portuguese) which is committed to foster neuroscience literacy and fight misinformation in the Portuguese community.
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Identificação

Identificação pessoal

Nome completo
Raquel Sofia Freitas Boia

Nomes de citação

  • Boia, Raquel
  • Boia, R.

Identificadores de autor

Ciência ID
B914-BBE9-9F8C
ORCID iD
0000-0002-0479-3066
Scopus Author Id
56587954800

Endereços de correio eletrónico

  • raquelfboia@gmail.com (Profissional)

Websites

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Formação
Grau Classificação
2022/09/27 - 2022/09/29
Concluído
 “Novel Challenges in Toxicology” (Outros)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2022/07/05 - 2022/07/07
Concluído
 “Competency based skills training in mice and rats” (Outros)
Universidade de Coimbra Faculdade de Medicina, Portugal
2022/05/20
Concluído
 Workshop L2B²-T: “Ajudar os alunos a reter, recuperar e aplicar conhecimentos: estratégias baseadas na evidência” (Outros)
Universidade de Coimbra Faculdade de Medicina, Portugal
2015/10 - 2021/09/21
Concluído
 Inter-University Doctoral Programme in Ageing and Chronic Disease (Doutoramento)
Universidade de Coimbra Faculdade de Medicina, Portugal
"Activation of A3 adenosine receptor using intraocular biodegradable implants as a strategy for the treatment of glaucoma" (TESE/DISSERTAÇÃO)
 Approved with praise and distinction
2021/07/21
Concluído
 Workshop "Definição de Procedimento e Classificação de Severidade de Dor" (Outros)
Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine of University of Coimbra, Portugal
2021/05/06
Concluído
 Workshop "Comunicação de Experimentação Animal" (Outros)
Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine of University of Coimbra, Portugal
2016/11/28 - 2016/12/02
Concluído
 II Quantitative Fluorescence Microscopy Course (Outros)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2016/01/11 - 2016/01/28
Concluído
 Biostatistics in Health Sciences, 6th edition (Outros)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2015/05/04 - 2015/05/15
Concluído
 Laboratory Animal Science Course - Category C (Outros)
Instituto de Biologia Molecular e Celular, Portugal
2015/03/30 - 2015/04/01
Concluído
 FRAME Training School in Experimental Design and Statistical Analysis of Biomedical Experiments (Outros)
Universidade de Coimbra, Portugal
2014/11/07 - 2014/11/08
Concluído
 "Profiling alterations in microglia dynamic properties by neuroinflammation" (Outros)
Faculty of Pharmacy of University of Lisbon (iMed.ULisboa), Portugal
2011 - 2013
Concluído
 Biochemistry (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Modulation of pro-inflammatory response of retina by adenosinergic system - Neuroinflammation/Neuroprotection" (TESE/DISSERTAÇÃO)
 18
2013
Concluído
 Online Course on Laboratory Animal Science, covering topics recommended by FELASA for category B (Outros)
Sociedade Portuguesa de Ciências em Animais de Laboratório, Portugal
2009 - 2011
Concluído
 Biochemistry (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"n/a" (TESE/DISSERTAÇÃO)
 13,45
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2019/10 - Atual Investigador Contratado (Investigação) Vector B2B - Drug development - Association for Research in Biotechnology, Portugal
Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine of University of Coimbra, Portugal
2013 - 2015 Investigador (Investigação) Universidade de Coimbra Faculdade de Medicina, Portugal
Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine of University of Coimbra, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2022/07/10 - 2022/07/14 Experience in foreign labs in Laboratory of Prof. Manuel Vidal-Sanz, Grupo de Investigación de Oftalmología Experimental Universidad de Murcia Facultad de Medicina, Espanha
2018/07/01 - 2018/07/30 Experience in foreign labs in Laboratory of Prof. Manuel Vidal-Sanz, Grupo de Investigación de Oftalmología Experimental Universidad de Murcia Facultad de Medicina, Espanha
2015/04/12 - 2015/04/20 Experience in foreign labs in Laboratory of Prof. Manuel Vidal-Sanz, Grupo de Investigación de Oftalmología Experimental Universidad de Murcia Facultad de Medicina, Espanha
Projetos

Bolsa

Designação Financiadores
2015/10 - 2019/09 Activation of A3 adenosine receptor using intraocular biodegradable implants as a strategy for the treatment of glaucoma
PD/BD/114115/2015
Bolseiro de Doutoramento
Fundação para a Ciência e a Tecnologia

Projeto

Designação Financiadores
2023/03/12 - Atual Deciphering the role of Piezo1 mechanosensitive channel in microglia-mediated glaucomatous neurodegeneration
2022.01354.PTDC
Investigador
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
Em curso
2023/01 - 2026/12 A new therapeutic approach to leverage vision restoration in glaucoma.
n.a.
Investigador responsável
Medalhas de Honra L’Oréal para as Mulheres na Ciência
Em curso
2016/07 - 2019/12 Biodegradable intravitreal porous implants for the extended release of A3 adenosine receptor agonist for the treatment of glaucoma
PTDC/NEU-OSD/3123/2014
Investigador
Fundação para a Ciência e a Tecnologia
Concluído
2015/12 - 2018/02 Managing inflammation in diabetic retinopathy by adenosine A2A receptor blockade
US2083156314
Investigador
Global Ophthalmology Awards Program - Bayer HealthCare
Concluído
2016/06 - 2017/07 Exosomes as amplifiers of inflammation: microglia-Müller cell communication in glaucoma.
GAI-Santander Totta 2016_224
Investigador
Universidade de Coimbra Faculdade de Medicina
Concluído
2014/01 - 2015/12 The potential protective effect of caffeine in the retina: relevance for the treatment of glaucoma.
n/a
Investigador
MANUEL RUI AZINHAIS NABEIRO LDA
Concluído
2015/04 - 2015/10 Biodegradable intravitreal porous implants for extended release of A3 adenosine receptor agonist for the protection of retinal ganglion cells
ASantiago.GAI2015
Investigador
Universidade de Coimbra Faculdade de Medicina
Concluído
2013/06 - 2015/09 From neuroinflammation control to neuroprotection: blocking adenosine A2A receptor for the treatment of glaucoma.
PTDC/BIM-MEC/0913/2012
Bolseiro de Investigação
Fundação para a Ciência e a Tecnologia
Concluído
2013/05 - 2013/10 Adenosine A3 receptor: a new therapeutic target for the treatment of glaucoma?
GAI Santiago06.01.13
Investigador
Universidade de Coimbra Faculdade de Medicina
Concluído
Produções

Publicações

Artigo em conferência
  1. Aires, Inês Dinis; Boia, Raquel; Ribeiro-Rodrigues, Teresa M; Girao, Henrique; Ambrósio, António Francisco; Santiago, Ana Raquel. "Exosomes from microglia under elevated pressure promote retinal neuroinflammation and degeneration". Trabalho apresentado em GLIA, Porto, 2019.
    10.1002/glia.23675
  2. Braga, Mara E.M.; Dias, Paulo A.N.; Boia, Raquel; Martins, J.M.; Ambrósio, A.F.; Santiago, A.R.; de Sousa, Hermínio C.. "Porous and Safe Ocular Implants Developed by scCO2 Foaming/Mixing for Increased Degradation Rate". Trabalho apresentado em 12th International Symposium on Supercritical Fluids (ISSF 2018), Juan-Les-Pins, 2018.
    Publicado
  3. Boia, Raquel. "Development of Innovative Porous Ocular Implants by a Green Supercritical Foaming/Mixing Technology". Trabalho apresentado em 16th European Meeting on Supercritical Fluids (EMSF), Lisbon, 2017.
    Publicado
  4. Ambrósio, António Francisco; Aires, I; Catarina Neves; Boia, Raquel; Madeira, Maria Helena Bica; Ana Raquel Santiago. "Control of microglia reactivity elicited by elevated hydrostatic pressure through A2A receptor blockade.". Trabalho apresentado em Society for Neuroscience Annual Meeting ¿ Neuroscience 2015, Chicago, 2015.
    Publicado
Artigo em revista
  1. Santiago, Ana Raquel; Aires, Inês Dinis; Agudo-Barriuso, Marta; Boia, Raquel. "Editorial: Molecular and cellular players of axonal regeneration in injured CNS". Frontiers in Neuroscience 17 (2023): https://doi.org/10.3389/fnins.2023.1315632.
    10.3389/fnins.2023.1315632
  2. Cabrera-Maqueda, José María; Boia, Raquel; Lucas-Ruiz, Fernando; González-Riquelme, María José; Ambrósio, António Francisco; Santiago, Ana Raquel; Vidal-Sanz, Manuel; Agudo-Barriuso, Marta; Galindo-Romero, Caridad. "Neuroinflammation and gliosis in the injured and contralateral retinas after unilateral optic nerve crush". Experimental Eye Research 235 (2023): 109627. http://dx.doi.org/10.1016/j.exer.2023.109627.
    10.1016/j.exer.2023.109627
  3. Realinho, Ana M.; Boia, Raquel; Paiva, Beatriz; Correia, Raquel G.; Gaspar, Rita; Ambrósio, António F.; Baptista, Filipa I.. "Maternal diabetes affects rat offspring retinal structure and function: Sex-specific vulnerabilities at infancy". Life Sciences 327 (2023): 121852. http://dx.doi.org/10.1016/j.lfs.2023.121852.
    10.1016/j.lfs.2023.121852
  4. Sanches, Eliane Swely; Boia, Raquel; Silva, Ana Paula; Leitão, Ricardo Alexandre; Medeiros, Maria; Md; Sanches, Eliane S.; et al. "Attention-Deficit/Hyperactivity Disorder animal model presents retinal alterations and methylphenidate has a differential effect in ADHD versus control conditions (under revision)". Antioxidants 12 4 (2023): 937. http://dx.doi.org/10.3390/antiox12040937.
    Em revisão • 10.3390/antiox12040937
  5. María José González-Riquelme; Fernando Lucas-Ruiz; Caridad Galindo-Romero; Raquel Boia; António Francisco Ambrósio; Manuel Vidal-Sanz; Ana Raquel Santiago; Marta Agudo-Barriuso. "Comparative Analysis of Retinal Organotypic Cultures and In Vivo Axotomized Retinas". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24043481.
    10.3390/ijms24043481
  6. Boia, Raquel; Dias, Paulo A.N.; Galindo-Romero, Caridad; Ferreira, Hugo; Aires, Inês D.; Vidal-Sanz, Manuel; Agudo-Barriuso, Marta; et al. "Intraocular implants loaded with A3R agonist rescue retinal ganglion cells from ischemic damage". Journal of Controlled Release 343 (2022): 469-481. http://dx.doi.org/10.1016/j.jconrel.2022.02.001.
    10.1016/j.jconrel.2022.02.001
  7. Riquelme, Maria Josefa Gonzalez; Lucas-Ruiz, Fernando; Boia, Raquel; Santiago, Ana Raquel; Vidal-Sanz, Manuel; Galindo-Romero, Caridad; Agudo-Barriuso, Marta. "Course of retinal ganglion cell loss and microglial activation in two models of neuronal degeneration". Acta Ophthalmologica (2022): https://publons.com/wos-op/publon/54356176/.
    10.1111/J.1755-3768.2022.211
  8. Aires, Inês Dinis; Ribeiro-Rodrigues, Teresa; Boia, Raquel; Ferreira-Rodrigues, Magda; Girão, Henrique; Ambrósio, António Francisco; Santiago, Ana Raquel. "Microglial Extracellular Vesicles as Vehicles for Neurodegeneration Spreading". Biomolecules 11 6 (2021): 770. http://dx.doi.org/10.3390/biom11060770.
    10.3390/biom11060770
  9. Ferreira-Silva, Joana; Aires, Inês D.; Boia, Raquel; Ambrósio, António Francisco; Santiago, Ana Raquel. "Activation of Adenosine A3 Receptor Inhibits Microglia Reactivity Elicited by Elevated Pressure". International Journal of Molecular Sciences 21 19 (2020): 7218. http://dx.doi.org/10.3390/ijms21197218.
    10.3390/ijms21197218
  10. Aires, Inês Dinis; Ribeiro-Rodrigues, Teresa; Boia, Raquel; Catarino, Steve; Girão, Henrique; Ambrósio, António Francisco; Santiago, Ana Raquel. "Exosomes derived from microglia exposed to elevated pressure amplify the neuroinflammatory response in retinal cells". Glia 68 12 (2020): 2705-2724. http://dx.doi.org/10.1002/glia.23880.
    10.1002/glia.23880
  11. Boia, Raquel; Salinas-Navarro, Manuel; Gallego-Ortega, Alejandro; Galindo-Romero, Caridad; Aires, Inês D.; Agudo-Barriuso, Marta; Ambrósio, António Francisco; Vidal-Sanz, Manuel; Santiago, Ana Raquel. "Activation of adenosine A3 receptor protects retinal ganglion cells from degeneration induced by ocular hypertension". Cell Death & Disease 11 5 (2020): http://dx.doi.org/10.1038/s41419-020-2593-y.
    10.1038/s41419-020-2593-y
  12. Boia, Raquel; Ruzafa, Noelia; Aires, Inês Dinis; Pereiro, Xandra; Ambrósio, António Francisco; Vecino, Elena; Santiago, Ana Raquel. "Neuroprotective Strategies for Retinal Ganglion Cell Degeneration: Current Status and Challenges Ahead". International Journal of Molecular Sciences 21 7 (2020): 2262. http://dx.doi.org/10.3390/ijms21072262.
    10.3390/ijms21072262
  13. Santiago, Ana Raquel; Madeira, Maria H.; Boia, Raquel; Aires, Inês Dinis; Rodrigues-Neves, Catarina; Santos, Paulo Fernando; Ambrósio, António Francisco. "Keep an eye on adenosine: Its role in retinal inflammation". Pharmacology & Therapeutics (2020): 107513. http://dx.doi.org/10.1016/j.pharmthera.2020.107513.
    10.1016/j.pharmthera.2020.107513
  14. Boia, Raquel; Dias, Paulo A.N.; Martins, Joana M.; Galindo-Romero, Caridad; Aires, Inês D.; Vidal-Sanz, Manuel; Agudo-Barriuso, Marta; et al. "Porous poly(e-caprolactone) implants: A novel strategy for efficient intraocular drug delivery". Journal of Controlled Release 316 (2019): 331-348. http://dx.doi.org/10.1016/j.jconrel.2019.09.023.
    10.1016/j.jconrel.2019.09.023
  15. Aires, Inês Dinis; Madeira, Maria Helena; Boia, Raquel; Rodrigues-Neves, Ana Catarina; Martins, Joana Margarida; Ambrósio, António Francisco; Santiago, Ana Raquel. "Intravitreal injection of adenosine A2A receptor antagonist reduces neuroinflammation, vascular leakage and cell death in the retina of diabetic mice". Scientific Reports 9 1 (2019): http://dx.doi.org/10.1038/s41598-019-53627-y.
    10.1038/s41598-019-53627-y
  16. Aires, Inês Dinis; Boia, Raquel; Rodrigues-Neves, Ana Catarina; Madeira, Maria Helena; Marques, Carla; Ambrósio, António Francisco; Santiago, Ana Raquel. "Blockade of microglial adenosine A2A receptor suppresses elevated pressure-induced inflammation, oxidative stress, and cell death in retinal cells". Glia 67 5 (2019): 896-914. http://dx.doi.org/10.1002/glia.23579.
    10.1002/glia.23579
  17. Santiago, Ana Raquel; Aires, Ines Dinis; Ribeiro-Rodrigues, Teresa; Boia, Raquel; Catarino, Steve; Almeida, Daniela; Girao, Henrique; Ambrosio, Antonio F.. "Extracellular vesicles released by microglia exposed to elevated hydrostatic pressure promote retinal neural cell loss and microglia reactivity". Investigative Ophthalmology & Visual Science (2019): https://publons.com/wos-op/publon/28332477/.
  18. Boia, Raquel; Salinas-Navarro, Manuel; Gallego-Ortega, Alejandro; Galindo-Romero, Caridad; Agudo-Barriuso, Marta; Ambrosio, Antonio F.; Vidal-Sanz, Manuel; Raquel Santiago, Ana. "Adenosine A3 receptor agonist prevents the loss of retinal ganglion cells in a glaucoma model". Investigative Ophthalmology & Visual Science (2019): https://publons.com/wos-op/publon/28944127/.
  19. Santiago, Ana R.; Boia, Raquel; Aires, Inês D.; Ambrósio, António F.; Fernandes, Rosa. "Sweet Stress: Coping With Vascular Dysfunction in Diabetic Retinopathy". Frontiers in Physiology 9 (2018): http://dx.doi.org/10.3389/fphys.2018.00820.
    10.3389/fphys.2018.00820
  20. Rodrigues-Neves, Ana C.; Aires, Inês D.; Vindeirinho, Joana; Boia, Raquel; Madeira, Maria H.; Gonçalves, Francisco Q.; Cunha, Rodrigo A.; et al. "Elevated Pressure Changes the Purinergic System of Microglial Cells". Frontiers in Pharmacology 9 (2018): http://dx.doi.org/10.3389/fphar.2018.00016.
    10.3389/fphar.2018.00016
  21. Alves, Mariana R. P.; Boia, Raquel; Campos, Elisa J.; Martins, Joao; Nunes, Sara; Madeira, Maria H.; Santiago, Ana Raquel; et al. "Subtle thinning of retinal layers without overt vascular and inflammatory alterations in a rat model of prediabetes". Molecular Vision 24 (2018): 353-366. https://publons.com/wos-op/publon/7412815/.
  22. Boia, Raquel; Elvas, Filipe; Madeira, Maria H; Aires, Inês D; Rodrigues-Neves, Ana C; Tralhão, Pedro; Szabó, Eszter C; et al. "Treatment with A2A receptor antagonist KW6002 and caffeine intake regulate microglia reactivity and protect retina against transient ischemic damage". Cell Death & Disease 8 10 (2017): e3065-e3065. http://dx.doi.org/10.1038/cddis.2017.451.
    10.1038/cddis.2017.451
  23. Boia, Raquel. "Having a Coffee Break: The Impact of Caffeine Consumption on Microglia-Mediated Inflammation in Neurodegenerative Diseases.". Mediators of inflammation (2017): http://europepmc.org/abstract/med/28250576.
    10.1155/2017/4761081
  24. Madeira, Maria H.; Boia, Raquel; Elvas, Filipe; Martins, Tiago; Cunha, Rodrigo A.; Ambrósio, António Francisco; Santiago, Ana Raquel. "Selective A2A receptor antagonist prevents microglia-mediated neuroinflammation and protects retinal ganglion cells from high intraocular pressure–induced transient ischemic injury". Translational Research 169 (2016): 112-128. http://dx.doi.org/10.1016/j.trsl.2015.11.005.
    10.1016/j.trsl.2015.11.005
  25. Boia, Raquel; Ambrósio, António Francisco; Santiago, Ana Raquel. "Therapeutic Opportunities for Caffeine and A2A Receptor Antagonists in Retinal Diseases". Ophthalmic Research 55 4 (2016): 212-218. http://dx.doi.org/10.1159/000443893.
    10.1159/000443893
  26. Madeira, Maria H.; Elvas, Filipe; Boia, Raquel; Gonçalves, Francisco Q.; Cunha, Rodrigo A.; Ambrósio, António Francisco; Santiago, Ana Raquel. "Adenosine A2AR blockade prevents neuroinflammation-induced death of retinal ganglion cells caused by elevated pressure". Journal of Neuroinflammation 12 1 (2015): http://dx.doi.org/10.1186/s12974-015-0333-5.
    10.1186/s12974-015-0333-5
  27. Madeira, Maria H.; Boia, Raquel; Santos, Paulo F.; Ambrósio, António F.; Santiago, Ana R.. "Contribution of Microglia-Mediated Neuroinflammation to Retinal Degenerative Diseases". Mediators of Inflammation 2015 (2015): 1-15. http://dx.doi.org/10.1155/2015/673090.
    10.1155/2015/673090
Poster em conferência
  1. Sanches, Eliane Swely; Boia, Raquel; Leitão, Ricardo Alexandre; Maria Helena Bica Madeira; Carlos Alberto Fontes Ribeiro; António Francisco Ambrósio; Rosa Cristina S Fernandes; Ana Paula Silva. "A pre-clinical study to analyze the retinal alterations in Attention Deficit/Hyperactivity Disorder (ADHD) and the effect of methylphenidate". Trabalho apresentado em 5th National Congress of ADHD (5º Congresso Nacional PHDA), 2022.
  2. Sanches, Eliane Swely; Boia, Raquel; Leitão, Ricardo; Maria H. Madeira; Carlos Alberto Fontes Ribeiro; António Francisco Ambrósio; Fernandes, Rosa; Ana Paula Pereira da Silva Martins. "Retinal alterations in Attention-Deficit/Hyperactivity Disorder and the effect of methylphenidate treatment: a pre-clinical study". Trabalho apresentado em 35th ECNP Congress, 2022.
  3. Sanches, Eliane Swely; Boia, R.; Leitão, Ricardo Alexandre; Maria Helena Bica Madeira; Carlos Alberto Fontes Ribeiro; António Francisco Rosa Gomes Ambrósio; Rosa Cristina S Fernandes; Ana Paula Pereira da Silva Martins. "Retinal alterations in Attention-deficit/Hyperactivity Disorder and control conditions with(out) methylphenidate treatment". Trabalho apresentado em 35th ECNP Congress, 2022.
  4. Cruz, Alexandra; Boia, Raquel; Gaspar, Rita; Sara Nunes; Baptista, FI; António Francisco Ambrósio; Hugo Fernandes. "Assessment of the impact of an early acute immune challenge on the diabetic retina". Trabalho apresentado em The Biochemistry Global Summit, 2022.
  5. Ambrosio, A.F. ; Cruz, Alexandra ; Boia, Raquel; Fernandes, Hugo; Gaspar, Rita; Nunes, Sara; Baptista, Filipa. "Impact of an early primary immune challenge on the retinal dysfunction upon a secondary chronic diabetic insult.". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neurosciencce, 2021.
  6. Sanches, ESAM; Boia, Raquel; Leitão, Ricardo Alexandre; Madeira, Maria; Fontes-Ribeiro, Carlos A; António Francisco Ambrósio; Fernandes, Rosa; Ana Paula Pereira da Silva Martins. "Retinal physiology and function in control and ADHD conditions with(out) methylphenidate treatment". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  7. António Francisco Ambrósio; Alexandra F. Cruz; Boia, Raquel; Gaspar, Rita; Nunes, Sara; Baptista, FI. "Impact of an Early Immune Challenge on the Retinal Dysfunction upon a Secondary Chronic Diabetic Insult". Trabalho apresentado em XVII Reunião da Sociedade Portuguesa de Neurociências, 2021.
  8. Santos, Carolina; Pereiro, Xandra; Boia, Raquel; Vecino, Elena; A.F. Ambrosio; Santiago, Ana Raquel. "Microvesicles released by Müller glial cells promote the survival of retinal ganglion cells". Trabalho apresentado em V Symposium of the Portuguese Glial Network - Glial cells at the crossroad of health and disease, 2021.
  9. Ferreira-Rodrigues, M; Aires ID; Ribeiro-Rodrigues, Teresa M; Boia, Raquel; Girao, Henrique; António Francisco Ambrósio; Santiago, Ana Raquel. "Intravitreal injection of microglia-derived microvesicles induces retinal inflammation and retinal ganglion cell loss". Trabalho apresentado em 3rd Symposium on Physiology & Pathology of Neuroglia, 2020.
  10. Sanches, ESAM; Boia, Raquel; Leitão, Ricardo Alexandre; Martins, Joao; Fontes-Ribeiro, Carlos A; António Francisco Ambrósio; Fernandes, Rosa; Ana Paula Pereira da Silva Martins, PhD. "Impact of Methylphenidate on the Retina in Control and ADHD conditions". Trabalho apresentado em SPF Meeting 2020 - Sociedade Portuguesa de Farmacologia (Portuguese Society of Pharmacology), 2020.
  11. Santos, Carolina; Boia, Raquel; Aires, Inês Dinis; Ambrósio, A.F.; Santiago, Ana Raquel. "The adenosine A3 receptor agonist is protective to the retinas of diabetic mice". Trabalho apresentado em IV Symposium of the Portuguese Glial Network - Glia Diversity in Neuromodulation and Neurodegeneration, 2019.
  12. Ferreira-Silva, Joana; Boia, Raquel; Aires, Inês Dinis; Martins, Joana Margarida ; Ambrósio, A.F.; Santiago, AR. "Activation of A3 receptors prevents microglial reactivity triggered by elevated hydrostatic pressure". Trabalho apresentado em III Symposium of the Portuguese Glial Network, 2019.
  13. Silva, Ana Paula; Madeira, Maria H.; Coelho-Santos, Vanessa; Leitão, Ricardo Alexandre; Boia, Raquel; Fontes-Ribeiro, Carlos A.; Fernandes, Rosa. "An eye on ADHD: Can the retina be used as a diagnostic support tool?". Trabalho apresentado em 7th World Congress on ADHD, 2019.
  14. Boia, Raquel; Martins, Joana Margarida ; Dias, Paulo A N; Galindo-Romero, C; Vidal-Sanz, M.; AGUDO-BARRIUSO, MARTA; C. de Sousa, Hermínio; et al. "Safety of a new biodegradable poly(e-caprolactone) implant to the retina of Wistar rats". Trabalho apresentado em XXIII Biennial Meeting of the International Society for Eye Research, 2018.
  15. Santos, Carolina; Boia, Raquel; Aires, Inês Dinis; Ambrósio, A.F.; Santiago, Ana Raquel. "Effect of adenosine A3 receptor agonist treatment in microglial reactivity in a mouse model of diabetic retinopathy". Trabalho apresentado em III Symposium of the Portuguese Glial Network, 2018.
  16. Martins, Joana Margarida ; Boia, Raquel; Ambrósio, A.F.; Santiago, AR. "Activation of adenosine A3 receptor prevents pressure-induced retinal neuronal cell death.". Trabalho apresentado em XV Meeting of the Portuguese Society for Neuroscience, 2017.
  17. Boia, Raquel; Tralhão, P.; Madeira, Maria Helena Bica; Elvas, Filipe; Müller, Christa E.; Cunha, Rodrigo A.; Ambrósio, António Francisco; Ana Raquel Santiago. "Caffeine and the selective A2AR antagonist KW6002 afford protection and control neuroinflammation in a model of transient retinal ischemia". Trabalho apresentado em VII Annual Meeting of IBILI, 2015.
  18. Boia, Raquel; Madeira, Maria Helena Bica; Elvas, Filipe; Martins, T; Ambrósio, António Francisco; Ana Raquel Santiago. "Antagonism of adenosine A2A receptor prevents retinal ganglion cell loss and neuroinflammation in a model of transient retinal ischemia". Trabalho apresentado em 6th Annual Alliance for Healthy Aging, 2015.
  19. Boia, Raquel; Madeira, Maria Helena Bica; Elvas, Filipe; Martins, T; Ambrósio, António Francisco; Ana Raquel Santiago; Queiroz-Gonçalves, F.; Cunha, Rodrigo A.. "Blockade of adenosine A2A receptor prevents retinal ganglion cell loss through the control of neuroinflammation: possible role in glaucoma". Trabalho apresentado em XIV Meeting of the Portuguese Society for Neurosciences, 2015.
  20. Ana Raquel Santiago; Boia, Raquel; Madeira, Maria Helena Bica; Elvas, Filipe; Martins, T; Cunha, Rodrigo A.; Ambrósio, António Francisco. "The blockade of adenosine A2A receptor inhibits retinal neuroinflammation and cell death". Trabalho apresentado em VI Annual Meeting of IBILI, 2014.
  21. Aires, I; Boia, Raquel; Madeira, Maria Helena Bica; Ambrósio, António Francisco; Ana Raquel Santiago. "A2A receptor blockade prevents pressure-induced microglia reactivity". Trabalho apresentado em VI Annual Meeting of IBILI, 2014.
  22. Ambrósio, António Francisco; Elvas, F; Correia, S.R.; Madeira, Maria Helena Bica; Martins, João; Martins, T; Boia, Raquel; Cavadas, C; Ana Raquel Santiago. "Modulation of pro-inflammatory responses in the retina by Neuropeptide Y: the role of NPY Y1 receptor". Trabalho apresentado em XXI Biennial Meeting of the International Society for Eye Research, 2014.
  23. Ana Raquel Santiago; Boia, Raquel; Tralhão, P.; Elvas, Filipe; Madeira, Maria Helena Bica; Ambrósio, António Francisco. "Adenosine A2A receptor blockade and caffeine modulate retinal neuroinflammation following ischemia-reperfusion injury". Trabalho apresentado em XXI Biennial Meeting of the International Society for Eye Research, 2014.
  24. Boia, Raquel; Madeira, Maria Helena Bica; Elvas, Filipe; Tralhão, P.; Martins, T; Ambrósio, António Francisco; Ana Raquel Santiago. "Adenosine A2A receptor blockade and caffeine prevent retinal neuroinflammation and retinal ganglion cell death". Trabalho apresentado em The international Symposium on ocular pharmacology and therapeutics, 2014.
  25. Madeira, Maria Helena Bica; Boia, Raquel; Elvas, Filipe; Ambrósio, António Francisco; Ana Raquel Santiago. "Adenosine A2A receptor blockade controls retinal neuroinflammation in experimental models of glaucoma". Trabalho apresentado em Microglia: Guardians of the Brain, 2014.
  26. Correia, S.R.; Martins, João; Boia, Raquel; Madeira, Maria Helena Bica; Ana Raquel Santiago; Ambrósio, António Francisco. "Modulation of pro-inflammatory responses in the retina by sitagliptin and the role of neuropeptide Y1 receptor". 2014.
  27. Boia, Raquel; Tralhão, P.; Madeira, Maria Helena Bica; Elvas, Filipe; Szabo, E.; Tomé, A; Ambrósio, António Francisco; Ana Raquel Santiago. "Chronic caffeine administration prevents retinal neuroinflammation and cell death in a rat retinal ischemia-reperfusion model". 2014.
  28. Boia, Raquel; Tralhão, P.; Madeira, Maria Helena Bica; Elvas, Filipe; Tomé, A; Ambrósio, António Francisco; Ana Raquel Santiago; Szabo, E.; Tomé, A.. "Caffeine inhibits neuroinflammation and cell death in the retina induced by ischemia-reperfusion injury". Trabalho apresentado em EMBO - Young Scientist Forum, 2013.
Resumo em conferência
  1. Sanches, Eliane Swely; Boia, Raquel; Maria H. Madeira; Leitão, Ricardo Alexandre; Baptista, FI; António Francisco Rosa Gomes Ambrósio; Fernandes, Rosa; Ana Paula Pereira da Silva Martins. "Unveilling the impact of methylphenidate misuse on the retina". Trabalho apresentado em 54th Meeting of the Portuguese Society of Pharmacology, 42nd Meeting of Clinical Pharmacology and 23rd Meeting of Toxicology, Lisbon, 2024.
    Publicado
  2. Sanches, Eliane Swely; Boia, Raquel; Leitão, Ricardo Alexandre; Carlos Alberto Fontes Ribeiro; António Francisco Rosa Gomes Ambrósio; Fernandes, Rosa; Ana Paula Pereira da Silva Martins. "Unveilling the effects of Methylphenidate on the retina of control and Attention-Deficit/Hyperactivity Disorder rat models". Trabalho apresentado em 52nd Meeting of the Portuguese Society of Pharmacology, 40th Meeting of Clinical Pharmacology and 21st Meeting of Toxicology, Porto, 2022.
    Publicado
  3. Boia, R.; Dias, Paulo A.N.; Galindo-Romero, C.; Aires, I.D.; Vidal-Sanz, M.; Agudo-Barriuso, M.; Santos, P.F.; et al. "Activation of the adenosine A3 receptor as a new strategy to rescue retinal ganglion cells from ischemic damage". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience, Coimbra, 2021.
    Publicado
  4. Boia, R.; Dias, Paulo A.N.; Galindo-Romero, C.; Aires, I.D.; Vidal-Sanz, M.; Agudo-Barriuso, M.; Santos, P.F.; et al. "Intraocular biodegradable implants loaded with A3 receptor agonist rescue retinal ganglion cells from ischemic damage". Trabalho apresentado em 2021 CRS Virtual Annual Meeting, Web conference, 2021.
    Publicado
  5. Boia, R.; Dias, Paulo A.N.; Galindo-Romero, C.; Aires, I.D.; Vidal-Sanz, M.; Agudo-Barriuso, M.; Santos, P.F.; et al. "Long-lasting retinal neuroprotection by an adenosine A3 receptor agonist loaded in an intraocular biodegradable implant". Trabalho apresentado em 3rd SPLC-CRS Young Scientists Virtual Meeting, Web conference, 2021.
    Publicado
  6. Boia, R.; Dias, Paulo A.N.; Galindo-Romero, C.; Aires, I.D.; Vidal-Sanz, M.; Agudo-Barriuso, M.; Santos, P.F.; et al. "Intraocular biodegradable implant loaded with adenosine A3 receptor agonist as a strategy for the treatment of glaucoma". Trabalho apresentado em 50.ª Reunião da Sociedade Portuguesa de Farmacologia, Coimbra, 2020.
    Publicado
  7. Boia, R.; Dias, Paulo A.N.; Galindo-Romero, C.; Martins, J.; Aires, I.D.; Vidal-Sanz, M.; Agudo-Barriuso, M.; et al. "Biodegradable intraocular implant loaded with adenosine A3 receptor agonist affords protection against retinal ischemic injury". Trabalho apresentado em 5th ISOPT Clinical: The International Symposium on Ocular Pharmacology & Therapeutics, The Retina Chapter, Valencia, 2019.
    Publicado
  8. Boia, Raquel; Martins, J.M.; Dias, Paulo A.N.; Galindo-Romero, C.; Vidal-Sanz, M.; Agudo-Barriuso, M.; de Sousa, Hermínio C.; et al. "A new drug delivery system for glaucoma patients: poly(e-caprolactone) biodegradable intravitreal implants". Trabalho apresentado em XII Spanish-Portuguese Conference on Controlled Drug Delivery, Tailoring drug delivery systems to the patients¿ needs, Coimbra, 2018.
    Publicado
  9. Boia, Raquel; Martins, J.M.; Dias, Paulo A.N.; Galindo-Romero, C.; Vidal-Sanz, M.; Agudo-Barriuso, M.; de Sousa, Hermínio C.; et al. "Biodegradable Porous Intravitreal Implants for Extended Drug Release: An Opportunity For Retinal Ganglion Cell Neuroprotection?". Trabalho apresentado em ISER/BrightFocus 2017 meeting, Basic science catalyzing treatments for glaucoma, Atlanta, Georgia, 2017.
    Publicado
  10. alves, MP; Boia, Raquel; Campos, Elisa J.; Martins, João; Nunes, Sara; madeira, mh; Reis, Flávio; et al. "Early retinal changes in a rat model of prediabetes: assessment of blood-retinal barrier permeability, neural markers and inflammatory mediators". Trabalho apresentado em 7th Annual Meeting of IBILI, Coimbra, 2015.
    Publicado
  11. Inês Aires; Boia, Raquel; Catarina Neves; Madeira, Maria Helena Bica; Ambrósio, António F.; Santiago, Ana R.; Aires, I; Ambrósio, António Francisco; Ana Raquel Santiago. "A2A receptor blockade prevents microglia reactivity triggered by elevated hydrostatic pressure". Trabalho apresentado em Glia Meeting, Bilbao, 2015.
    Publicado
  12. Boia, Raquel; Madeira, Maria Helena Bica; Elvas, Filipe; Tiago Martins; Ambrósio, António F.; Santiago, Ana Raquel. "Blockade of adenosine A2A receptor confers neuroprotection against retinal ischemia-reperfusion injury through the control of neuroinflammation". Trabalho apresentado em Glia Meeting, Bilbao, 2015.
    Publicado
Tese / Dissertação
  1. "Activation of A3 adenosine receptor using intraocular biodegradable implants as a strategy for the treatment of glaucoma.". Doutoramento, Universidade de Coimbra, 2020. https://estudogeral.uc.pt/handle/10316/98625.
  2. "Modulation of pro-inflammatory response of retina by adenosinergic system - Neuroinflammation/Neuroprotection.". Mestrado, Universidade de Coimbra, 2013. https://estudogeral.sib.uc.pt/handle/10316/24659.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2024/04/30 Restoring vision in glaucoma: may the adenosine A3 receptor be a therapeutic target? Meet my Science from CIBB
(Portugal)
2023/10/18 Invited Speaker - A new therapeutic approach to leverage vision restoration in glaucoma”. DVC.Talks
(Coimbra, Portugal)
2023/10 Small extracellular vesicles derived from reactive microglia contribute to retinal neuroinflammation and neurodegeneration 26th EVER congress
(Valencia, Espanha)
2023/06/21 Invited Speaker - “A new therapeutic approach to leverage vision restoration in glaucoma”. Instituto de Medicina Molecular João Lobo Antunes (iMM)
(Lisboa, Portugal)
2023/06 Non-canonical anti-inflammatory effects of sitagliptin on (retinal) microglia. 33rd Conference of the European Association for the Study of Diabetes Eye Complications
(Coimbra, Portugal)
2023/03 Alterações estruturais e funcionais na retina induzidas pela diabetes durante a gravidez nos descendentes durante a infância: diferente vulnerabilidade associada ao sexo. 19º Congresso Português de Diabetes (SPD)
(Vilamoura, Portugal)
2022/12 Glial response in the injured and contralateral retinas after unilateral optic nerve crush. Optic Nerve Meeting
(Obergurgl, Áustria)
2021/06 Morphological Changes of Microglial Cells: Comparison between Retinal Organotypic Cultures and In vivo Axotomized Retinas SIREV Congress
(Murcia, Espanha)
2021/06 Brain Inflammatory Response after an Unilateral Optic Nerve Damage in Mice. Retinal Organotypic Cultures and In vivo Axotomized Retinas. SIREV Congress
(Murcia, Espanha)
2021/02 Intraocular biodegradable implants loaded with adenosine A3 receptor agonist afford protection to retinal ganglion cells 51.ª Reunião da Sociedade Portuguesa de Farmacologia
(Portugal)
2021/02 Impact of methylphenidate on the retina in control and ADHD conditions. 51.ª Reunião da Sociedade Portuguesa de Farmacologia
(Coimbra, Portugal)
2021/01/21 Long-lasting retinal neuroprotection by an adenosine A3 receptor agonist loaded in an intraocular biodegradable implant 3rd SPLC-CRS Young Scientists Meeting (virtual)
2021/01/20 Activation of A3 adenosine receptor using intraocular biodegradable implants as a strategy for the treatment of glaucoma CIBB Neuroscience and Disease - data club
(Portugal)
2021/01/13 Activation of A3 adenosine receptor using intraocular biodegradable implants as a strategy for the treatment of glaucoma iCBR scientific meeting
(Portugal)
2020/11 Intravitreal injection of microglia-derived microvesicles induces retinal inflammation and retinal ganglion cell loss. 3rd Symposium on Physiology and Pathology of Neuroglia
2020/10 Resident retinal microglia amplify the neuroinflammatory response initiated by exosomes derived from reactive microglia. PhDOC retreat annual meeting 2020 (online)
2020/02/07 Intraocular biodegradable implant loaded with adenosine A3 receptor agonist as a strategy for the treatment of glaucoma 50.ª Reunião da Sociedade Portuguesa de Farmacologia
(Portugal)
2019/12 Invited Speaker - Long-lasting retinal neuroprotection using an intraocular implant with adenosine A3 receptor agonist CIBB annual meeting 2019
(Coimbra, Portugal)
2019/11 Biodegradable intraocular implant loaded with adenosine A3 receptor agonist affords protection against retinal ischemic injury. 15th ISOPT Clinical: The International Symposium on Ocular Pharmacology & Therapeutics
(Valencia, Espanha)
2019/10 Microglial extracellular vesicles induce glial reactivity and retinal degeneration in glaucomatous conditions. PhDOC retreat annual meeting 2019
(Coimbra, Portugal)
2019/07 Exosomes derived from microglia exposed to elevated pressure code for an inflammatory response: implications for retinal degeneration. XIV European Meeting on Glial Cells in Health and Disease
(Porto, Portugal)
2019/05/29 Controlling microglia-mediated neuroinflammation in retinal diseases: role of adenosine A2A receptors IV Symposium of the Portuguese Glial Network
(Lisbon, Portugal)
2019/05/10 Invited Speaker - Activation of A3 adenosine receptor using intraocular biodegradable implants as a neuroprotective strategy against glaucomatous degeneration. CIBB Neuroscience and Disease – Retreat
(Coimbra, Portugal)
2019/04/27 Adenosine A3 receptor agonist prevents the loss of retinal ganglion cells in a glaucoma model Pan-American Research Day
University of British Columbia (Vancouver, Canadá)
2019/04/27 Extracellular vesicles released by microglia exposed to elevated hydrostatic pressure promote retinal neural cell loss and microglia reactivity.
(Vancouver, Canadá)
2018/10 Microglial response to optic nerve injuries 2018 European Association for Vision and Eye Research Conference (EVER)
(Nice, França)
2018/09 Elevated Hydrostatc Pressure-derived Microglial Extracellular Vesicles Drive Microglia Reactvity: Contributon to Neuroinflammatory Response in Glaucoma Models XXIII Biennial Meeting of the International Society for Eye Research in Belfast (ISER)
(Northern Ireland, Reino Unido)
2017/09 Contribution of microglia-mediated neuroinflammation to retinal degenerative diseases XXthEuropean Association for Vision and Eye Research (EVER)
(Nice, França)
2017/04 Development of Innovative Porous Ocular Implants by a Green Supercritical Foaming/Mixing Technology. 16th European Meeting on Supercritical Fluids (EMSF)
(Lisboa, Portugal)
2016/12 Treatment with an A2A receptor antagonist reduces neuroinflammation and protects the retina against ischemic damage 13th ISOPT Clinical symposium
(Rome, Itália)
2016/09 The Blockade of Adenosine A2A Receptor Affords Neuroprotection through the Control of Microglia Mediated Neuroinflammation in Experimental Models of Glaucoma. XXII Biennial Meeting of the International Society for Eye Research (ISER)
(Tóquio, Japão)
2016/09 Impact of Elevated Pressure in the Adenosinergic System in Microglia and Retina. XXII Biennial Meeting of the International Society for Eye Research (ISER)
(Tóquio, Japão)
2015/03 Prediabetes does not induce changes in tight junction proteins, neural markers and inflammatory mediators in the rat retina. LIMSC
(Países Baixos)
2014/12/11 Adenosine A2A receptor blockade and caffeine modulate neuroinflammation following retinal ischemia-reperfusion injury VI Annual Meeting of IBILI
(Coimbra, Portugal)
2014/06 Adenosine A2A receptor blockade and caffeine prevent retinal neuroinflammation and retinal ganglion cell death. 11th ISOPT clinical
(Reykjavik, Islândia)
2014/03 Role of neuroinflammation in retinal degenerative diseases: microglia as a potential therapeutic target. I Simpósio da Rede Glial Luso-Brasileira
(Rio de Janeiro, Brasil)
2013/09 Adenosine A2A receptor blockade and caffeine decrease retinal neuroinflammation. FENS Featured Regional Meeting
(Praga, República Checa)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2023/09 - Atual Unraveling the role of Piezo1 channel activation in elevated pressure-exposed microglia: effect on oxidative stress, proliferation, and antigen presentation
Coorientador
 Química Medicinal (Mestrado)
Universidade de Coimbra, Portugal
2023/09 - Atual Role of Piezo1 in microglia-mediated neuroinflammation: Dissecting the role of Piezo1 activation in the retina
Coorientador
 Investigação Biomédica (Mestrado)
Universidade de Coimbra, Portugal
2023/09 - Atual Adenosine A3 receptor activation as a strategy for axon regeneration in glaucoma
Orientador
 Neurociências Molecular e de Translação (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2022/09 - 2023/10/23 Role of Piezo1 mechanosensitive channel in elevated pressure-induced microglia reactivity
Coorientador
 Investigação Biomédica (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2021/03/04 - 2021/06/14 Efeito do agonista do recetor de adenosina A3 no tratamento das alterações induzidas pela Diabetes do tipo 1 na retina
Orientador de João Pires
2017/09/04 - 2017/09/29 Biodegradable intravitreal porous implants for the extended release of A3 adenosine receptor agonist for the treatment of glaucoma
Orientador de Anna-Maria Graubner
Universidade de Coimbra Faculdade de Medicina, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2023/11 - Atual Cycle of seminars "Meet My Science", an event organized by Postdocs@CIBB Representatives, which aims to showcase, once a month, the scientific work carried out at CIBB. (2023/11)
Seminário (Membro da Comissão Organizadora)
 Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2022/05/10 - 2022/05/31 Organized a seminar series entitled "May is Healthy Vision Month". These 4 seminars aimed at promoting the discussion between basic researchers and clinicians on the challenges of pre-clinical research and its translation to the patients, Online. (2022/05/10 - 2022/05/31)
Seminário (Outra)
 Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine of University of Coimbra, Portugal
2019/10/30 - 2019/10/31 Member of the organizing committee of the "VIII Annual PhDOC meeting" (2019/10/30 - 2019/10/31)
Congresso (Membro da Comissão Organizadora)
2016/10/14 - 2016/10/15 Member of the organizing committee of the "V Annual PhDOC meeting" (2016/10/14 - 2016/10/15)
Conferência (Membro da Comissão Organizadora)

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2019 - Atual Visit to the Basic School "Centro Ilda Moreno de Montemor-o-Velho", "Escola de Alvaiázere" and "Agrupamento de Escolas de Anadia" to participate on the initiative "Scientists go to School" within the framework of the Brain Awareness Week. Brain Awareness Week 2019
2019 - Atual Coordination, planning and visit to the School "Centro Escolar da Figueira da Foz" to participate on the initiative "Scientists go to School" within the framework of the Brain Awareness Week. Brain Awareness Week 2019
2018 - Atual Coordination, planning and visit to the "Basic School of Abadias, Figueira da Foz" to participate on the initiative "Scientists go to School" within the framework of the Brain Awareness Week. Brain Awareness Week 2018
2018 - Atual Participation and co-coordination in the activities related with Noite Europeia dos Investigadores - Guerra das cores (European Researchers Night), that took place at the Nucleo Museológico do Mar, Figueira da Foz European Researchers’ Night 2018
2017 - Atual Visit to the "Elementary School from Anadia" to participate in the activity "Scientists go to School" within the framework of the Brain Awareness Week. Brain Awareness Week 2017
2017 - Atual Participation and co-coordination in the activities related with Noite Europeia dos Investigadores - Uma noite com sentidos (European Researchers Night), that took place at the Nucleo Museológico do Mar, Figueira da Foz European Researchers’ Night 2017

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2025/01/30 Social Stimulus Encoding in Neurodevelopmental Disorders Using Mouse Models
Arguente principal
 Muzakir Jamil Dawood Parkar (Mestrado)
2024/02/21 Sexual steroid modulation of glucocorticoid-induced changes in mitochondria of microglia
Arguente principal
 Jéssica Santos Monteiro (Mestrado)
2023/07/18 Efeito da ativação do Piezo-1 na imunoreatividade da iNOS em células da microglia.
Arguente principal
 Sara Costa (Outro)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2023/06/19 Otimização de técnicas e criação de modelo celular para o estudo do EYS na retinopatia pigmentar
Arguente principal
 Sofia Pereira Nunes da Silva (Outro)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2022/10/25 Unravel the role of p-cadherin expression in ovarian cancer cell lines.
Arguente
 Inês Morgado de Sá (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2022/10/03 Alterações epigenéticas desencadeadas pelo stress e depressão materna durante a gravidez.
Arguente principal
 Ana Catarina Cerejeira Silva (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2022/07/22 Alterações Mitocondriais Associadas a Experiências Adversas na Infância e a sua Relação com Patologias Mentais na Vida Adulta
Arguente principal
 Alcina de Fátima Gonçalves (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2022/07/08 Papel da ativação do mecanorrecetor Piezo-1 em células da microglia na neuro-inflamação
Arguente principal
 Solange Trindade Castanheira (Outro)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2015/06/23 Estudo das Alterações Histológicas e Funcionais na Retina de Rato Após Elevação Aguda da Pressão Intraocular
Arguente principal
 Joana Cláudia Ferreira da Silva (Outro)
Instituto Politécnico de Coimbra Escola Superior Agrária de Coimbra, Portugal

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2024 - Atual Special Issue “Cell Therapy in the Central Nervous System and its Crosstalk with the Immune System” Frontiers in Cellular Neuroscience
2022/01/24 - Atual Special issue "Molecular and cellular players of axonal regeneration in injured CNS" (1662-453X) Frontiers in Neurosciences
2022 - Atual Molecular Neurobiology Springer
2022 - Atual Special Issue “Retinal Neurodegenerative Diseases: Molecular Targets Driving Neuroinflammation and Neuroprotection 2022” International Journal of Molecular Sciences
2021/11/25 - Atual Special issue "The Senescence of The Retina" (1662-5129) Frontiers in Neuroanatomy
2021 - Atual Acta Biomaterialia Elsevier
2021 - Atual Cells MDPI
2021 - Atual Drug Design, Development and Therapy Dove Medical Press
2021 - Atual Journal of Clinical Medicine MDPI
2021 - Atual Journal of Ophthalmology Hindawi
2020 - Atual Special Issue "Retinal Neurodegenerative Diseases: Molecular Targets Driving Neuroinflammation and Neuroprotection" (ISSN 1422-0067) MDPI AG
2020 - Atual International Journal of Molecular Sciences MDPI
2019 - Atual Biomedicine Hub Karger

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2024/07 - Atual Laboratorial tutor of Ciência Viva no Laboratório (28ª edição) - “Como estudamos no laboratório as doenças que afetam a visão?”
2024/07 - Atual Laboratorial tutor of Ciência Viva no Laboratório (28ª edição) - “Culturas celulares de microglia para estudar o glaucoma”
2024/04 - Atual Collaborator on teaching classes of medical students (Immunology II), Integrated Master Degree in Medicine, Faculty of Medicine, University of Coimbra.
2024/04 - Atual Laboratorial tutor of the curricular unit “Investigação em Ortóptica II”, Bachelor degree in Orthoptics, Escola Superior de Saúde do Politécnico do Porto
2023/04 - Atual Lecture entitled “Can immune system be a key mediator of axonal regeneration in CNS?” for the Immunology course from Doctoral Program in Health Sciences, Faculty of Medicine, University of Coimbra
2023/04 - Atual Lecture entitled “Restoring vision in glaucoma: may the adenosine A3 receptor be a therapeutic target?”, advanced course “Vision Sciences”, PhD Programme in Health Sciences, Master in Biomedical Research (MIB), Faculty of Medicine, University of Coimbra
2023/03 - Atual Practical Lecture of the advanced course “Visual System and Related Pathologies”, Master in Molecular and Translational Neuroscience (MNMT), Faculty of Medicine, University of Coimbra
2024/09 - 2024/10 Laboratorial tutor of the curricular unit “Cellular Regulation” from Master in Biomedical Research (MIB), Faculty of Medicine, University of Coimbra, September 20 - October 7
2021/11/02 - 2021/11/03 Long-lasting retinal neuroprotection by an adenosine A3 receptor agonist loaded in an intraocular biodegradable implant Master in Biomedical Research Faculty of Medicine of University of Coimbra, Portugal
2021/03/04 - 2021/06/14 Laboratorial tutor of Applied Research IV Integrated Master in Medicine Universidade de Coimbra, Portugal
2019/02/25 - 2019/03/01 Laboratorial tutor of the advanced course "Vision Sciences" Doctoral Program in Health Sciences Faculty of Medicine of University of Coimbra, Portugal
2018/03/12 - 2018/03/16 Laboratorial tutor of the advanced course "Vision Sciences" Doctoral Program in Health Sciences Faculty of Medicine of University of Coimbra, Portugal
2017/09/26 - 2017/10/06 Laboratorial tutor of the Course of Sciences in Laboratory Animals - Modules 21 and 22 (practice) Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine of University of Coimbra, Portugal
2017/03/06 - 2017/03/10 Laboratorial tutor of the advanced course "Vision Sciences" Doctoral Program in Health Sciences Faculty of Medicine of University of Coimbra, Portugal
2016/02/29 - 2016/03/04 Laboratorial tutor of the advanced course "Vision Sciences" Doctoral Program in Health Sciences Faculty of Medicine of University of Coimbra, Portugal
2015/03/09 - 2015/03/13 Laboratorial tutor of the advanced course "Vision Sciences" Doctoral Program in Health Sciences Faculty of Medicine of University of Coimbra, Portugal

Membro de associação

Nome da associação Tipo de participação
2024/03/22 - Atual Associação Fala-me Neuro Member of the Direction board
2014 - Atual Sociedade Portuguesa de Bioquímica
2013 - Atual Sociedade Portuguesa de Neurociências

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2023/11 - Atual Postdocs@CIBB Representatives
Membro
 Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2022/01 - Atual Member of science communication project "Fala-me Neuro" which is committed to communicate neuroscience in Portuguese to the society.
Membro

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2023 - Atual Member of the jury for the selection of one research fellowship in the framework of the project “PRESING - Deciphering the role of Piezo1 mechanosensitive channel in microglia-mediated glaucomatous neurodegeneration” (reference: 2022.01354.PTDC), funded by FCT.
2023 - Atual Member of the jury for the selection of one research fellowship in the framework of the project “Evaluation of the best therapeutic strategies for the treatment of retinal diseases using animal models” (reference: L928162), financed by FMUC revenues. Universidade de Coimbra, Portugal
2022 - Atual Member of the jury for the selection of one research fellowship in the framework of the project “Evaluation of neuroprotective therapeutic strategies for the treatment of animal models of neurodegenerative retinal diseases” (reference: BIOT-FM-21 - L768532), financed by FMUC revenues.

Tutoria

Tópico Nome do aluno
2019/01 - 2019/04 PhD student (collaboration in laboratorial supervision during his stay in Portugal) José María Cabrera Maqueda
2018/03/20 - 2018/04/13 PhD student (collaboration in laboratorial supervision during her laboratorial rotation) Daniela Antunes
2017/06 - 2017/09 PhD students (collaboration in laboratorial supervision during his stay in Portugal) Fernando Lucas Ruiz
2016/11 - 2016/12 PhD students (collaboration in laboratorial supervision during her laboratorial rotation) Gabriela Silva
2016/08 - 2016/09 Post-doctoral work (collaboration in laboratorial supervision during her stay in Portugal) Caridad Galindo Romero
Distinções

Prémio

2023 BEST ORAL COMMUNICATION
Sociedade Portuguesa de Diabetologia, Portugal
2022 L'ORÉAL PORTUGAL MEDALS OF HONOR FOR WOMEN IN SCIENCE, 2022
Fundação para a Ciência e a Tecnologia, Portugal
2021 BEST ORAL COMMUNICATION - 3rd SPLC-CRS Young Scientists Meeting 2021
3rd SPLC-CRS Young Scientists Meeting, Espanha
2021 SPN SCHOLARSHIP TO PARTICIPATE IN SPN2021
Sociedade Portuguesa de Neurociências, Portugal
2021 2021 LOCAL CHAPTER YOUNG SCIENTIST REGISTRATION AWARD
CRS and Local Chapter Spanish-Portuguese, Espanha
2014 BEST POSTER - Biochemical Portuguese Society
Sociedade Portuguesa de Bioquímica, Portugal

Outra distinção

2021 AWARD IN THE INNOVATORS CATEGORY BY THE IAPB EYE HEALTH HERO PROGRAMME 2021
IAPB Eye Health Hero Programme 2021, Reino Unido