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Luís Estronca finished the PhD in Chemistry (specialization in Biological Chemistry) in 2008 at the University of Coimbra. Currently is a Researcher at the Faculty of Medicine of the University of Coimbra. Published 13 peer-reviewed articles and 1 book chapter. Participated as a Researcher in 9 projects and as co-PI in two projects. Has experience in the following areas: Nanobiotechnology, Cell Biology, Vascular Biology, Molecular Biology, Stem cells, iPSC
Identificação

Identificação pessoal

Nome completo
LUÍS MIGUEL BEICINHA BRANCO ESTRONCA

Nomes de citação

  • Estronca, Luís
  • Estronca, LMBB
  • Estronca, LM

Identificadores de autor

Ciência ID
B914-E58A-F196
ORCID iD
0000-0001-8417-8313

Moradas

  • Universidade de Coimbra, Faculdade de Medicina. Biomaterials and Stem Cell-Based Therapeutics UC-Biotech Building - Parque Tecnológico de Cantanhede, Núcleo 4, Lote 8 , 3060-197, Cantanhede, Cantanhede, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências da Engenharia e Tecnologias - Nanotecnologia - Nanomateriais
  • Ciências Naturais - Ciências Biológicas - Biologia Celular
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Tecnologias que envolvem a Manipulação de Células,Tecidos,Órgãos ou todo o Organismo
Formação
Grau Classificação
2008
Concluído
 Química (Doutoramento)
Especialização em Química Biológica
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Primary Chemical Processes in Atherogenesis. Kinetics and Thermodynamics of Amphiphile Exchange between Serum Albumin, Lipoproteins and Lipid Bilayer Membranes" (TESE/DISSERTAÇÃO)
 Aprovado com Distinção e Louvor
Projetos

Projeto

Designação Financiadores
2021/11/01 - Atual Preservation of natural and cultural heritage and scientific validation of practices with medicinal plants from Côa Valley
COA/BRB/0019/2019
Investigador
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2021/05/20 - Atual RESEarch for healThy AGEING - RESETageing
Grant agreement ID: 952266
Investigador
Universidade de Coimbra, Portugal
 EU Framework Programme for Research and Innovation Euratom
Em curso
2020/11 - 2022/10 COVIRNA - A diagnostic test to improve surveillance and care of COVID-19 patients
Grant agreement ID: 101016072
Investigador
EU Framework Programme for Research and Innovation Science with and for Society
Em curso
2018/07/26 - 2022/05/25 An iPSC-derived vascular model of Progeria to identify mediators for smooth muscle loss
PTDC/BTM-SAL/29229/2017
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2018/07/06 - 2022/05/05 A light-activatable nanoparticle library for the delivery of RNA-based therapies
PTDC/EQU-EQU/29414/2017
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2016/11/17 - 2021/03/31 Era@UC - Enhancing Research in Ageing at The University of Coimbra
GA 669088 ERAatUC
Investigador
Universidade de Coimbra, Portugal
 EU Framework Programme for Research and Innovation Euratom
Concluído
2012/05/01 - 2015/09/30 Personalized 3D vascular constructs for toxicity assessment- VASCTOX
PTDC/SAU-TOX/121887/2010
Investigador
Fundação para a Ciência e a Tecnologia
Concluído
2011/01/01 - 2013/12/31 A sistematic functional analysis for Rab proteins in phagocytosis and phagosomal maturation of Mycobacterium tuberculosis
PTDC/BIA-BCM/112138/2009
Investigador
Concluído
2008/06/01 - 2010/08/31 ROLE AND MOLECULAR MECHANISMS UNDERLYING CD36-MEDIATED PHAGOCYTOSIS OF APOPTOTIC CELLS: IMPLICATIONS FOR ATHEROSCLEROSIS
PTDC/SAU-MII/66285/2006
Investigador
Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em revista
  1. Santinha, Deolinda; Vilaça, Andreia; Estronca, Luís; Schüler, Svenja C.; Bartoli, Catherine; De Sandre-Giovannoli, Annachiara; Figueiredo, Arnaldo; et al. "Remodelling of the cardiac extracellular matrix proteome during chronological and pathological ageing". Molecular & Cellular Proteomics (2023): 100706. http://dx.doi.org/10.1016/j.mcpro.2023.100706.
    Publicado • 10.1016/j.mcpro.2023.100706
  2. Estronca, Luís; Francisco, Vitor; Pitrez, Patrícia; Honório, Inês; Carvalho, Lara; Vazão, Helena; Blersch, Josephine; et al. "Induced pluripotent stem cell-derived vascular networks to screen nano-bio interactions". Nanoscale Horizons (2021): http://dx.doi.org/10.1039/d0nh00550a.
    10.1039/d0nh00550a
  3. Pitrez, Patricia R.; Estronca, Luís; Monteiro, Luís Miguel; Colell, Guillem; Vazão, Helena; Santinha, Deolinda; Harhouri, Karim; et al. "Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13". Nature Communications 11 1 (2020): http://dx.doi.org/10.1038/s41467-020-17901-2.
    10.1038/s41467-020-17901-2
  4. Pitrez, Patricia R.; Estronca, Luís; Vazão, Helena; Egesipe, Anne-Laure; Le Corf, Amélie; Navarro, Claire; Lévy, Nicolas; et al. "Substrate Topography Modulates Cell Aging on a Progeria Cell Model". ACS Biomaterials Science & Engineering 4 5 (2018): 1498-1504. http://dx.doi.org/10.1021/acsbiomaterials.8b00224.
    10.1021/acsbiomaterials.8b00224
  5. Domingues, N.; Estronca, L.M.B.B.; Silva, J.; Encarnação, M.R.; Mateus, R.; Silva, D.; Santarino, I.B.; et al. "Cholesteryl hemiesters alter lysosome structure and function and induce proinflammatory cytokine production in macrophages". Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 1862 2 (2017): 210-220. http://www.scopus.com/inward/record.url?eid=2-s2.0-84999089924&partnerID=MN8TOARS.
    10.1016/j.bbalip.2016.10.009
  6. Inácio, Â.S.; Domingues, N.S.; Nunes, A.; Martins, P.T.; Moreno, M.J.; Estronca, L.M.; Fernandes, R.; et al. "Quaternary ammonium surfactant structure determines selective toxicity towards bacteria: Mechanisms of action and clinical implications in antibacterial prophylaxis". Journal of Antimicrobial Chemotherapy 71 3 (2016): 641-654. http://www.scopus.com/inward/record.url?eid=2-s2.0-84960839711&partnerID=MN8TOARS.
    10.1093/jac/dkv405
  7. Estronca, L.M.B.B.; Filipe, H.A.L.; Salvador, A.; Moreno, M.J.; Vaz, W.L.C.. "Homeostasis of free cholesterol in the blood: A preliminary evaluation and modeling of its passive transport". Journal of Lipid Research 55 6 (2014): 1033-1043. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901660412&partnerID=MN8TOARS.
    10.1194/jlr.M043067
  8. Viegas, M.S.; Estronca, L.M.B.B.; Vieira, O.V.. "Comparison of the Kinetics of Maturation of Phagosomes Containing Apoptotic Cells and IgG-Opsonized Particles". PLoS ONE 7 10 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84868316815&partnerID=MN8TOARS.
    10.1371/journal.pone.0048391
  9. Estronca, L.M.B.B.; Silva, J.C.P.; Sampaio, J.L.; Shevchenko, A.; Verkade, P.; Vaz, A.D.N.; Vaz, W.L.C.; Vieira, O.V.. "Molecular etiology of atherogenesis - in vitro induction of lipidosis in macrophages with a new LDL model". PLoS ONE 7 4 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84859710740&partnerID=MN8TOARS.
    10.1371/journal.pone.0034822
  10. Estronca, Luís M.B.B.; Moreno, Maria João; Vaz, Winchil L.C.. "Kinetics and Thermodynamics of the Association of Dehydroergosterol with Lipid Bilayer Membranes". Biophysical Journal 93 12 (2007): 4244-4253. http://dx.doi.org/10.1529/biophysj.107.112847.
    10.1529/biophysj.107.112847
  11. Moreno, M.J.; Estronca, L.M.B.B.; Vaz, W.L.C.. "Translocation of phospholipids and dithionite permeability in liquid-ordered and liquid-disordered membranes". Biophysical Journal 91 3 (2006): 873-881. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746714404&partnerID=MN8TOARS.
    10.1529/biophysj.106.082115
  12. Estronca, L.M.B.B.; Moreno, M.J.; Laranjinha, J.A.N.; Almeida, L.M.; Vaz, W.L.C.. "Kinetics and thermodynamics of lipid amphiphile exchange between lipoproteins and albumin in serum". Biophysical Journal 88 1 (2005): 557-565. http://www.scopus.com/inward/record.url?eid=2-s2.0-11244253621&partnerID=MN8TOARS.
    10.1529/biophysj.104.047050
  13. Abreu, M.S.C.; Estronca, L.M.B.B.; Moreno, M.J.; Vaz, W.L.C.. "Binding of a fluorescent lipid amphiphile to albumin and its transfer to lipid bilayer membranes". Biophysical Journal 84 1 (2003): 386-399. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037216785&partnerID=MN8TOARS.
  14. Estronca, L.M.B.B.; João Moreno, M.; Abreu, M.S.C.; Melo, E.; Vaz, W.L.C.. "Solubility of amphiphiles in membranes: Influence of phase properties and amphiphile head group". Biochemical and Biophysical Research Communications 296 3 (2002): 596-603. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036384222&partnerID=MN8TOARS.
    10.1016/S0006-291X(02)00905-1
Capítulo de livro
  1. Estronca, L.; Ferreira, L.. "Stem Cells for the Regeneration of Chronic Wounds: A Translational Perspective". 2016.
    10.1016/B978-0-444-63265-4.00013-3