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Rui Costa has an MSc (2008) and PhD (2013) in Biomedical Engineering from the University of Minho (UMINHO), in collaboration with University of Valladolid (Spain). Rui Costa is an Assistant Researcher (Portuguese FCT fellowship) at 3Bs from the ICVS/3Bs Associated Lab since 2023. He has been researching biomimetic and self-organization approaches applied to natural-derived biomaterials to obtain biomedical devices with controlled physicochemical properties, multifunctionality, cellular response and drug reservoir ability. His other contributions include the development of nanostructured core/shell systems and the encapsulation of bioactive substances and living cells. Rui Costa has delivered 43 indexed publications (h-index=20, over 1700 citations, Scopus), of which 5 are book chapters. He is a reviewer in over 20 different high ranked international journals from the most reputed publishers, including Advanced Materials and Acta Biomaterialia. In 2020 his interests converged to the fabrication of gene and drug vehicles for breast cancer treatments, and the processing of natural polysaccharides (with emphasis on glycosaminoglycans) via electrostatic complexation. Under these topics, between 2020-2025 he was PI of project OncoNeoTreat (PTDC/CTM-REF/0022/2020) to develop inorganic-templated layer-by-layer microcapsules with multimodal drug loading to treat breast cancer. Rui Costa received two self-grants under the competitive Scientific Employment program of the Portuguese Foundation for Science and Technology (FCT): Junior (Starting) Researcher fellowship (2019-2023) to develop nanostructured carriers for cancer treatments, and Assistant Researcher (2023-ongoing) under the same topic. In the last five years, he has participated in other 7 national FCT projects totaling about €1.8M and has been core member of two EU Horizon projects in health-enabling applications: APTADEGRAD (2022-2027, €600k) and ARTPLAC (2023-2027, €600k), counting with 8 academic members, 4 enterprises and 3 public bodies. Rui Costa received two IACOBUS Paper Awards (2020, 2025) which distinguishes collaborations between North Portugal and Spanish Galicia. He also received an IACOBUS Travel Award (2020) to work at University of Santiago de Compostela with Prof. Pablo Taboada on hybrid liposome/recombinant elastin nanoparticles with improved cell internalization. He was an Invited Professor at the Department of Polymers Engineering of UMINHO in 2017. His other teaching activities include volunteering to deliver lectures in the MIT-Portugal Bioengineering Program and developing content for the e-learning course on Tissue Engineering and Regenerative Medicine of UMINHO. In the last 5 years, Rui Costa has also co-supervised 1 MSc student and mentored 8 others (5 MSc and 3 PhD students).
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Identificação

Identificação pessoal

Nome completo
Rui Filipe Ramos da Costa

Identificadores de autor

Ciência ID
B91E-8A3D-3932
Scopus Author Id
7203063544

Endereços de correio eletrónico

  • rui.costa@i3bs.uminho.pt (Profissional)

Moradas

  • 3B's Research Group, I3Bs – Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, AvePark, Parque de Ciência e Tecnologia, Rua Ave 1, Edifício 1 (Sede), 4805-694, Barco, Guimarães, Portugal (Profissional)
Formação
Grau Classificação
2009/10/01 - 2013/12/19
Concluído
 Doctoral Program in Biomedical Engineering (Doutoramento)
Especialização em Tissue Engineering and Regenerative Medicine
Universidade do Minho Escola de Engenharia, Portugal
"Nanostructured Functional Multilayer Coatings Incorporating Biomimetic Macromolecules for Biomedical Applications" (TESE/DISSERTAÇÃO)
 Approved by unanimity
2003/09/01 - 2008/12/18
Concluído
 Integrated Master in Biomedical Engineering (Mestrado integrado)
Especialização em Biomaterials, Rehabilitation and Biomechanics
Universidade do Minho Escola de Engenharia, Portugal
"Development of Biomimetic Coatings Based on Chitosan and Elastin-Like Polymers for Medical Devices" (TESE/DISSERTAÇÃO)
 16
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2019/05/01 - 2023/03/31 Investigador Contratado (Investigação) Laboratório Associado ICVS 3B's, Portugal
Biomaterials Biodegradables and Biomimetics, Portugal
(...)
2014/04/01 - 2019/01/18 Pós-doutorado (Investigação) Laboratório Associado ICVS 3B's, Portugal
Biomaterials Biodegradables and Biomimetics, Portugal
(...)
2009/09/01 - 2013/12/19 Investigador (Investigação) Laboratório Associado ICVS 3B's, Portugal
Biomaterials Biodegradables and Biomimetics, Portugal
(...)
2012/10/01 - 2013/04/30 Investigador visitante (Investigação) Universidad de Valladolid Departamento de Física de la Materia Condensada Cristalografía y Mineralogía, Espanha

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2017/03/01 - 2017/11/16 Professor Auxiliar Convidado (Docente Universitário) Universidade do Minho Departamento de Engenharia de Polímeros, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2020/02/03 - 2020/04/30 Visiting Researcher (IACOBUS exchange programme) Universidade de Santiago de Compostela Departamento de Física de Partículas, Espanha
2008/03/03 - 2009/01/30 Master student Biomaterials Biodegradables and Biomimetics, Portugal
Universidade do Minho, Portugal
2007/09/03 - 2008/02/29 Visiting Researcher (ERASMUS exchange programme) Universidad de Valladolid Departamento de Física de la Materia Condensada Cristalografía y Mineralogía, Espanha
Projetos

Bolsa

Designação Financiadores
2014/04/01 - 2019/01/18 Layer-by-layer compartmentalized structures as customizable and multifuncional microreactors
SFRH/BPD/95446/2013
Bolseiro de Pós-Doutoramento
Laboratório Associado ICVS 3B's, Portugal
 Fundação para a Ciência e a Tecnologia (Portuguese FCT)
Concluído
2009/10/01 - 2013/09/30 Surface modification of biodegradable materials for the conception of innovative coatings with tunable cell adhesion properties and smart nature
SFRH/BD/61126/2009
Bolseiro de Doutoramento
Laboratório Associado ICVS 3B's, Portugal
 Fundação para a Ciência e a Tecnologia (Portuguese FCT)
Concluído

Projeto

Designação Financiadores
2024/04/01 - Atual Artificial Placenta (ArtPlac) - Miniaturized Integrated Lung and Kidney Support for Critically Ill Newborns
HORIZON-EIC-2022-PATHFINDEROPEN-01-101099596
10.3030/101099596
Investigador
Universidade do Minho, Portugal
 Horizon 2020
Em curso
2023/01/01 - Atual APTADEGRAD - A novel, first-in-its-kind, aptamer-based LYTACs to address the unmet clinical need of diabetic wounds
HORIZON-EIC-2022-PATHFINDEROPEN-01-101099063
10.3030/101099063
Investigador
Universidade do Minho, Portugal
 Horizon 2020
Em curso
2021/02/01 - Atual OncoNeoTreat - Inorganic-Templated and Polymeric Layer-by-Layer Microcapsules with Multimodal Drug Loading to Treat Breast Cancer
PTDC/CTM-REF/0022/2020
10.54499/PTDC/CTM-REF/0022/2020
Investigador responsável
Laboratório Associado ICVS 3B's, Portugal
 Fundação para a Ciência e a Tecnologia (Portuguese FCT)
Em curso
2023/04/01 - 2029/04/18 PolyTarget - Polyelectrolyte-Based Nanocarriers with Prospects of Targeting Breast Cancer Multiresistances
2022.00764.CEECIND/CP1718/CT0020
10.54499/2022.00764.CEECIND/CP1718/CT0020
Investigador responsável
Universidade do Minho, Portugal

Laboratório Associado ICVS 3B's, Portugal

Biomaterials Biodegradables and Biomimetics, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2022/01/01 - 2024/12/31 SpyPatch - Modular spider silk and elastin recombinamers for soft tissue repair patches
PTDC/BTM-MAT/2844/2021
Investigador
Laboratório Associado ICVS 3B's, Portugal
Em curso
2019/05/01 - 2023/03/31 SmartShuttle - Tackling Tumor Heterogeneity Using Biomaterial-Based Multifunctional Nanocarriers Against Cancer
10.54499/CEECIND/02842/2017/CP1458/CT0025
Investigador responsável
Biomaterials Biodegradables and Biomimetics, Portugal

Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia (Portuguese FCT)
Concluído
2020/07/31 - 2022/06/30 CardioHeal - Self-Healing Hydrogels with Extracellular Matrix Analogues for Cardiac Tissue Engineering
PTDC/BTM-MAT/28327/2017
Investigador
Laboratório Associado ICVS 3B's, Portugal
 Fundação para a Ciência e a Tecnologia (Portuguese FCT)
Em curso
2018/07/01 - 2021/06/30 SeaJellyBone - Multifunctional hydrogels inspired by mussels that combine bioactivity with superior adhesion for bone tissue regeneration
PTDC/BTM-MAT/28123/2017
Investigador
Laboratório Associado ICVS 3B's, Portugal
 Fundação para a Ciência e a Tecnologia (Portuguese FCT)
Em curso
2018/07/01 - 2021/06/30 BGcoat4Bone - Bioactive coatings containing new BioGlass nanoparticles for orthopedic applications
PTDC/BTM-MAT/28123/2017
Investigador
Laboratório Associado ICVS 3B's, Portugal
 Fundação para a Ciência e a Tecnologia (Portuguese FCT)
Em curso
2018/07/01 - 2021/06/30 Light2Skin - Photosensitive Capsules for Future Pharmaceutical Applications
PTDC/CTM-CTM/29813/2017
Investigador
Laboratório Associado ICVS 3B's, Portugal
 Fundação para a Ciência e a Tecnologia (Portuguese FCT)
Em curso
2015/06/01 - 2019/05/31 ELASTISLET - Tailored Elastin-like Recombinamers as Advanced Systems for Cell Therapies in Diabetes Mellitus: a Synthetic Biology Approach towards a Bioeffective and Immunoisolated Biosimilar Islet/Cell Niche
H2020-NMP-2014-two-stage 646075
Investigador
Universidade do Minho, Portugal
 Horizon 2020
Concluído
2016/01/01 - 2018/12/31 CHEM2NATURE - Enabling precision chemical methodologies applied to natural-based systems for the development of multifunctional biomedical devices
H2020-TWINN-2015 692333
Investigador
Universidade do Minho, Portugal
 Horizon 2020
Concluído
2011/07/01 - 2014/06/30 SupraRelax - Molecular Mobility of Biodegradable Polymers Ultra-Confined in Organized Supramolecular Geometries
PTDC/FIS/115048/2009
Investigador
Biomaterials Biodegradables and Biomimetics, Portugal
 Fundação para a Ciência e a Tecnologia (Portuguese FCT)
Concluído
2008/03/01 - 2010/12/31 NanoBioActive - Bioactive Materials Containing New Bioglass Nanoparticles for Biomedical Applications
PTDC/QUI/69263/2006
Investigador
Biomaterials Biodegradables and Biomimetics, Portugal
 Fundação para a Ciência e a Tecnologia (Portuguese FCT)
Concluído
Produções

Publicações

Artigo em conferência
  1. Costa, R.R.; Ribeiro, A.J.; Rodríguez-Cabello, J.C.; Mano, J.F.. "Nanostructured thin coatings from chitosan and an elastin-like recombinamer with acute stimuli-responsive behavior". Trabalho apresentado em VI International Materials Symposium MATERIAIS 2011 and XV meeting of SPM – Sociedade Portuguesa de Materiais, Guimarães, 2011.
    Publicado • 10.4028/www.scientific.net/MSF.730-732.32
Artigo em revista
  1. Rial, Ramón; Guimarães, Carlos F.; Gasperini, Luca; Brito, Alexandra; Costa, Rui R.; Ruso, Juan M.; Reis, Rui L.. "Precise multiphase hydrogel engineering of miniaturized 3D cancer architectures via computationally informed microfluidics". Matter 8 10 (2025): 102196. https://doi.org/10.1016/j.matt.2025.102196.
    10.1016/j.matt.2025.102196
  2. Rodrigues, L.C.; Gomes, J.M.; da Costa, D. Soares; Fernandes, E.M.; Costa, R.R.; Rodriguez-Cabello, J.C.; Silva, S.S.; Reis, R.L.. "3D tubular constructs based on natural polysaccharides and recombinant polypeptide synergistic blends as potential candidates for blood vessel solutions". International Journal of Biological Macromolecules 310 (2025): 143084. https://doi.org/10.1016/j.ijbiomac.2025.143084.
    10.1016/j.ijbiomac.2025.143084
  3. Albuquerque, Afonso V.; Soares da Costa, Diana; Correia, Cátia; Reis, Rui L.; Alves, Natália M.; Costa, Rui R.; Pashkuleva, Iva. Autor correspondente: Costa, Rui R.. "Effect of Hyaluronan Molecular Weight on the Stability and Biofunctionality of Microfibers Assembled by Interfacial Polyelectrolyte Complexation". ACS Applied Materials & Interfaces 17 2 (2025): 4199-4209. https://doi.org/10.1021/acsami.4c18335.
    10.1021/acsami.4c18335
  4. Costa, Rui R.; Domínguez-Arca, Vicente; Velasco, Brenda; Reis, Rui L.; Rodríguez-Cabello, José Carlos; Pashkuleva, Iva; Taboada, Pablo; Prieto, Gerardo. Autor correspondente: Costa, Rui R.. "Cholesterol Conjugated Elastin-like Recombinamers: Molecular Dynamics Simulations, Conformational Changes, and Bioactivity". ACS Applied Materials & Interfaces 16 48 (2024): 66327-66340. https://doi.org/10.1021/acsami.4c07285.
    10.1021/acsami.4c07285
  5. Martins, Sara A.; Costa, Rui R.; Brito, Alexandra; Reis, Rui L.; Alves, Natália M.; Pashkuleva, Iva; Soares da Costa, Diana. "Multifunctional calcium-based nanocarriers for synergistic treatment of triple-negative breast cancer". Journal of Colloid and Interface Science 674 (2024): 500-512. https://doi.org/10.1016/j.jcis.2024.06.159.
    10.1016/j.jcis.2024.06.159
  6. Gonçalves, Raquel R.; Peixoto, Daniela; Costa, Rui R.; Franco, Albina R.; Castro, Vânia I.B.; Pires, Ricardo A.; Reis, Rui L.; et al. "Antibacterial properties of photo-crosslinked chitosan/methacrylated hyaluronic acid nanoparticles loaded with bacitracin". International Journal of Biological Macromolecules 277 (2024): 134250. https://doi.org/10.1016/j.ijbiomac.2024.134250.
    10.1016/j.ijbiomac.2024.134250
  7. Fernandes, Eduarda; Costa, Rui R.; Machado, Raúl; Reis, Rui L.; Pashkuleva, Iva; Lúcio, Marlene. "A Label-Free Multitechnique Approach to Characterize the Interaction of Bioactive Compounds with Biomimetic Interfaces". Small Science In press (2024): 2300271. http://dx.doi.org/10.1002/smsc.202300271.
    Acesso aberto • No prelo • 10.1002/smsc.202300271
  8. Bastos, Filipa R.; Soares da Costa, Diana; Reis, Rui L.; Alves, Natália M.; Pashkuleva, Iva; Costa, Rui R.. "Layer-by-layer coated calcium carbonate nanoparticles for targeting breast cancer cells". Biomaterials Advances 153 (2023): 213563. http://dx.doi.org/10.1016/j.bioadv.2023.213563.
    Acesso aberto • Publicado • 10.1016/j.bioadv.2023.213563
  9. Costa, Rui R.; Caballero, David; Soares da Costa, Diana; Rodriguez-Trujillo, Romen; Kundu, Subhas C.; Reis, Rui L.; Pashkuleva, Iva. "Microfluidic-Assisted Interfacial Complexation of Extracellular Matrix Components to Mimic the Properties of Neural Tissues". Advanced Materials Technologies 8 19 (2023): 2300983. http://dx.doi.org/10.1002/admt.202300983.
    Publicado • 10.1002/admt.202300983
  10. Fonseca, Mário C.; Vale, Ana Catarina; Costa, Rui R.; Reis, Rui L.; Alves, Natália M.. "Exploiting Polyelectrolyte Complexation for the Development of Adhesive and Bioactive Membranes Envisaging Guided Tissue Regeneration". Journal of Functional Biomaterials 14 1 (2023): 3. http://dx.doi.org/10.3390/jfb14010003.
    Acesso aberto • Publicado • 10.3390/jfb14010003
  11. Costa, Rui R.; Reis, Rui L.; Pashkuleva, Iva. Autor correspondente: Costa, Rui R.. "Glycosaminoglycans as polyelectrolytes: implications in bioactivity and assembly of biomedical devices". International Materials Reviews (2022): 1-31. http://dx.doi.org/10.1080/09506608.2022.2026860.
    No prelo • 10.1080/09506608.2022.2026860
  12. Domínguez-Arca, Vicente; Costa, Rui R.; Carvalho, Ana M.; Taboada, Pablo; Leis, Rui R.; Prieto, Gerardo; Pashkuleva, Iva. "Liposomes embedded in layer by layer constructs as simplistic extracellular vesicles transfer model". Materials Science and Engineering: C 121 (2021): 111813. http://dx.doi.org/10.1016/j.msec.2020.111813.
    Publicado • 10.1016/j.msec.2020.111813
  13. Rial, Ramón; Costa, Rui R.; Reis, Rui L.; Liu, Zhen; Pashkuleva, Iva; Ruso, Juan M.. "Mineralization of Layer-by-Layer Ultrathin Films Containing Microfluidic-Produced Hydroxyapatite Nanorods". Crystal Growth & Design 19 11 (2019): 6351-6359. http://dx.doi.org/10.1021/acs.cgd.9b00831.
    Publicado • 10.1021/acs.cgd.9b00831
  14. Costa, Rui R.; Soares da Costa, Diana; Reis, Rui L.; Pashkuleva, Iva. "Bioinspired baroplastic glycosaminoglycan sealants for soft tissues". Acta Biomaterialia 87 (2019): 108-117. http://dx.doi.org/10.1016/j.actbio.2019.01.040.
    Publicado • 10.1016/j.actbio.2019.01.040
  15. Maciel, Jeanny S.; Azevedo, Sara; Correia, Clara R.; Costa, Ana M. S.; Costa, Rui R.; Magalhães, Francisco A.; Sousa Monteiro, Aliny Abreu; et al. "Oxidized Cashew Gum Scaffolds for Tissue Engineering". Macromolecular Materials and Engineering 304 3 (2019): 1800574. http://dx.doi.org/10.1002/mame.201800574.
    Publicado • 10.1002/mame.201800574
  16. Costa, R.R.; González-Pérez, M.; Herrero-Gutiérrez, M.; Pires, R.A.; Alonso, M.; Rodriguez-Cabello, J. C.; Reis, R.L.; Pashkuleva, I.. "Tuning the Stiffness of Surfaces by Assembling Genetically Engineered Polypeptides with Tailored Amino Acid Sequence". Biomacromolecules 19 8 (2018): 3401-3411. http://dx.doi.org/10.1021/acs.biomac.8b00723.
    Publicado • 10.1021/acs.biomac.8b00723
  17. Miranda, M.S.; Rodrigues, M.T.; Domingues, R.M.A.; Costa, R R.; Paz, Elvira; Rodríguez-Abreu, Carlos; Freitas, Paulo; et al. "Development of Inhalable Superparamagnetic Iron Oxide Nanoparticles (SPIONs) in Microparticulate System for Antituberculosis Drug Delivery". Advanced Healthcare Materials 7 15 (2018): 1800124. http://dx.doi.org/10.1002/adhm.201800124.
    Publicado • 10.1002/adhm.201800124
  18. Hatami, Javad; Silva, S.G.; Oliveira, M.B.; Costa, R.R.; Reis, R.L.; Mano, J.F.. "Multilayered Films Produced by Layer-by-Layer Assembly of Chitosan and Alginate as a Potential Platform for the Formation of Human Adipose-Derived Stem Cell aggregates". Polymers 9 12 (2017): 440. http://dx.doi.org/10.3390/polym9090440.
    Publicado • 10.3390/polym9090440
  19. Leite, A.J.; Costa, R.R.; Costa, A.M.S.; Maciel, J.S.; Costa, J.F.G.; de Paula, R.C.M.; Mano, J.F.. "The potential of cashew gum functionalization as building blocks for layer-by-layer films". Carbohydrate Polymers 174 (2017): 849-857. http://dx.doi.org/10.1016/j.carbpol.2017.06.055.
    Publicado • 10.1016/j.carbpol.2017.06.055
  20. De Trizio, A.; Srisuk, Pathomthat; Costa, R.R.; Fraga, A.G.; Modena, Tiziana; Genta, I.; Dorati, Rossella; et al. "Natural based eumelanin nanoparticles functionalization and preliminary evaluation as carrier for gentamicin". Reactive and Functional Polymers 114 (2017): 38-48. http://dx.doi.org/10.1016/j.reactfunctpolym.2017.03.004.
    Publicado • 10.1016/j.reactfunctpolym.2017.03.004
  21. Rodrigues, M.N.; Oliveira, M.B.; Costa, R.R.; Mano, J.F.. "Chitosan/Chondroitin Sulfate Membranes Produced by Polyelectrolyte Complexation for Cartilage Engineering". Biomacromolecules 17 6 (2016): 2178-2188. http://dx.doi.org/10.1021/acs.biomac.6b00399.
    Publicado • 10.1021/acs.biomac.6b00399
  22. Cardoso, M.J.; Caridade, S.G.; Costa, R.R.; Mano, J.F.. "Enzymatic Degradation of Polysaccharide-Based Layer-by-Layer Structures". Biomacromolecules 17 4 (2016): 1347-1357. http://dx.doi.org/10.1021/acs.biomac.5b01742.
    Publicado • 10.1021/acs.biomac.5b01742
  23. Cardoso, M.J.; Costa, R.R.; Mano, J.F.. "Marine Origin Polysaccharides in Drug Delivery Systems". Marine Drugs 14 2 (2016): 34. http://dx.doi.org/10.3390/md14020034.
    Acesso aberto • Publicado • 10.3390/md14020034
  24. Costa, R.R.; Costa, A.M.S.; Caridade, S.G.; Mano, J.F.. "Compact Saloplastic Membranes of Natural Polysaccharides for Soft Tissue Engineering". Chemistry of Materials 27 21 (2015): 7490-7502. http://dx.doi.org/10.1021/acs.chemmater.5b03648.
    Publicado • 10.1021/acs.chemmater.5b03648
  25. Silva, J.M.; Caridade, S.G.; Costa, R.R.; Alves, N.M.; Groth, Thomas; Picart, C.; Reis, R.L.; Mano, J.F.. "pH Responsiveness of Multilayered Films and Membranes Made of Polysaccharides". Langmuir 31 41 (2015): 11318-11328. http://dx.doi.org/10.1021/acs.langmuir.5b02478.
    Publicado • 10.1021/acs.langmuir.5b02478
  26. Costa, R.R.; Alatorre-Meda, Manuel; Mano, J.F.. "Drug nano-reservoirs synthesized using layer-by-layer technologies". Biotechnology Advances 33 6 (2015): 1310-1326. http://dx.doi.org/10.1016/j.biotechadv.2015.04.005.
    Publicado • 10.1016/j.biotechadv.2015.04.005
  27. Sher, P.; Correia, C.R.; Costa, R.R.; Mano, J.F.. "Compartmentalized bioencapsulated liquefied 3D macro-construct by perfusion-based layer-by-layer technique". RSC Advances 5 4 (2015): 2511-2516. http://www.scopus.com/inward/record.url?eid=2-s2.0-84916910833&partnerID=MN8TOARS.
    Publicado • 10.1039/c4ra11674g
  28. Costa, R.R.; Girotti, Alessandra; Santos, Mercedes; Arias, F.J.; Mano, J.F.; Rodríguez-Cabello, J.C.. "Cellular uptake of multilayered capsules produced with natural and genetically engineered biomimetic macromolecules". Acta Biomaterialia 10 6 (2014): 2653-2662. http://dx.doi.org/10.1016/j.actbio.2014.02.020.
    Publicado • 10.1016/j.actbio.2014.02.020
  29. Costa, R.R.; Mano, J.F.. "Polyelectrolyte multilayered assemblies in biomedical technologies". Chemical Society Reviews 43 10 (2014): 3453-3479. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899104646&partnerID=MN8TOARS.
    Publicado • 10.1039/c3cs60393h
  30. Costa, R.R.; Castro, E.; Arias, F.J.; Rodríguez-Cabello, J.C.; Mano, J.F.. "Multifunctional compartmentalized capsules with a hierarchical organization from the nano to the macro scales". Biomacromolecules 14 7 (2013): 2403-2410. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880063951&partnerID=MN8TOARS.
    Publicado • 10.1021/bm400527y
  31. Costa, R.R.; Testera, A.M.; Arias, F.J.; Rodríguez-Cabello, J.C.; Mano, J.F.. "Layer-by-layer film growth using polysaccharides and recombinant polypeptides: A combinatorial approach". Journal of Physical Chemistry B 117 22 (2013): 6839-6848. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879187608&partnerID=MN8TOARS.
    Publicado • 10.1021/jp4028518
  32. Costa, R.R.; Neto, A.I.; Calgeris, I.; Correia, C.R.; Pinho, A.C.M.; Fonseca, J.; Öner, E.T.; Mano, J.F.. "Adhesive nanostructured multilayer films using a bacterial exopolysaccharide for biomedical applications". Journal of Materials Chemistry B 1 18 (2013): 2367-2374. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879547212&partnerID=MN8TOARS.
    Publicado • 10.1039/c3tb20137f
  33. Costa, R.R.; Custódio, C.A.; Arias, F.J.; Rodríguez-Cabello, J.C.; Mano, J.F.. "Nanostructured and thermoresponsive recombinant biopolymer-based microcapsules for the delivery of active molecules". Nanomedicine: Nanotechnology, Biology, and Medicine 9 7 (2013): 895-902. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884289838&partnerID=MN8TOARS.
    Publicado • 10.1016/j.nano.2013.01.013
  34. Silva, Joana M.; Georgi, Nicole; Costa, Rui; Sher, Praveen; Reis, Rui L.; Van Blitterswijk, Clemens A.; Karperien, Marcel; Mano, João F.. "Nanostructured 3D Constructs Based on Chitosan and Chondroitin Sulphate Multilayers for Cartilage Tissue Engineering". PLoS ONE 8 2 (2013): e55451. http://dx.doi.org/10.1371/journal.pone.0055451.
    Publicado • 10.1371/journal.pone.0055451
  35. Costa, R.R.; Custõdio, C.A.; Arias, F.J.; Rodríguez-Cabello, J.C.; Mano, J.F.. "Layer-by-layer assembly of chitosan and recombinant biopolymers into biomimetic coatings with multiple stimuli-responsive properties". Small 7 18 (2011): 2640-2649. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052779197&partnerID=MN8TOARS.
    Publicado • 10.1002/smll.201100875
  36. Costa, R.R.; Custódio, C.A.; Testera, A.M.; Arias, F.J.; Rodríguez-Cabello, J.C.; Alves, N.M.; Mano, J.F.. "Stimuli-responsive thin coatings using elastin-like polymers for biomedical applications". Advanced Functional Materials 19 20 (2009): 3210-3218. http://www.scopus.com/inward/record.url?eid=2-s2.0-70350452405&partnerID=MN8TOARS.
    Publicado • 10.1002/adfm.200900568
  37. Barbosa, J.S.; Costa, R.R.; Testera, A.M.; Alonso, M.; Rodríguez-Cabello, J.C.; Mano, J.F.. "Multi-layered films containing a biomimetic stimuli-responsive recombinant protein". Nanoscale Research Letters 4 10 (2009): 1247-1253. http://www.scopus.com/inward/record.url?eid=2-s2.0-70449526811&partnerID=MN8TOARS.
    Publicado • 10.1007/s11671-009-9388-5
Capítulo de livro
  1. Costa, Rui R.; Reis, Rui L.; Pashkuleva, Iva. "Hydrogels formed by polyelectrolyte complexation". In Hydrogels for Tissue Engineering and Regenerative Medicine, editado por J. Miguel Oliveira; Joana Silva-Correia, 311-330. Elsevier, 2023.
    Publicado • 10.1016/b978-0-12-823948-3.00008-7
  2. Costa, R.R.; Mano, J.F.. "Three-Dimensional Multilayered Devices for Biomedical Applications". In Layer-by-Layer Films for Biomedical Applications, 363-384. Wiley-VCH Verlag GmbH & Co. KGaA, 2015.
    Publicado • 10.1002/9783527675869.ch17
  3. Costa, R.R.; Alves, N.M.; Rodríguez-Cabello, J.C.; Mano, J.F.. "Stimuli-Responsive Surfaces for Biomedical Applications". In Biomaterials Surface Science, editado por Taubert, A.; Mano, J.F.; Rodriguez-Cabello, J.C., 63-87. Wiley-VCH Verlag GmbH & Co. KGaA, 2013.
    Publicado • 10.1002/9783527649600.ch4
  4. Costa, R.R.; Mano, J.F.. "Layer-by-layer self-assembly techniques for nanostructured devices in tissue engineering". In Nanomaterials in Tissue Engineering, editado por Gaharwar, A.K.; Sant, S.; Hancock, M.J., 88-118. Elsevier, 2013.
    Publicado • 10.1533/9780857097231.1.88
  5. Costa, R.R.; Martín, L.; Mano, J.F.; Rodríguez-Cabello, J.C.. "Elastin-Like Macromolecules". In Biomimetic Approaches for Biomaterials Development, editado por Mano, J.F., 93-116. Wiley-VCH Verlag GmbH & Co. KGaA, 2012.
    Publicado • 10.1002/9783527652273.ch5
Distinções

Prémio

2025 IACOBUS Papers Award for Collaborative Scientific Publications in the Galicia - North Portugal Euroregion
Agrupamento Europeu de Cooperação Territorial – Galicia-Norte de Portugal (GNP-AECT), Espanha
2020 IACOBUS Papers Award for Collaborative Scientific Publications in the Galicia - North Portugal Euroregion
Agrupamento Europeu de Cooperação Territorial – Galicia-Norte de Portugal (GNP-AECT), Espanha
2020 IACOBUS Mobility Award of the Galicia - North Portugal Euroregion
Agrupamento Europeu de Cooperação Territorial – Galicia-Norte de Portugal (GNP-AECT), Espanha
2011 1st Prize for "Best Poster Award" of the 2011 School of Engineering Week of University of Minho
Universidade do Minho Escola de Engenharia, Portugal