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Gilberto Lourenço Alves is associate professor at the Faculty of Health Sciences of the University of Beira Interior (Covilhã, Portugal). He is PhD member of the Health Sciences Research Center (CICS-UBI) of the University of Beira Interior (Covilhã). Gilberto Alves was also the coordinator of the Biomedicinal Chemistry and Drug Research (BCDR) group at CICS-UBI between 2019-2021. He is (co)author of more than 160 peer review articles published in international journals and several book chapters. His main research interests include the development and application of in vitro tools to predict ADME and pharmacotoxicological properties of drugs and drug candidates; this involves the application of PAMPA, cell culture assays and tissues mounted in Ussing chambers to study drug absorption, disposition, and toxicity of compounds. Additionally, he has a vast experience in laboratory animal models for the study of human diseases (e.g. epilepsy) and in the characterization of the pharmacokinetics of drugs or novel compounds in rodents (mice and rats) following administration by various routes (oral, intraperitoneal, intravenous and intranasal routes). This kind of studies are used to support non-clinical drug discovery and development programs, assessment of potential drug-drug or herb-drug interactions and development of novel drug formulations. The development and validation of analytical methods of liquid chromatography to quantify drugs, metabolites or novel compounds in biological matrices or pharmaceutical formulations is also routinely performed according to the needs.
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Identificação

Identificação pessoal

Nome completo
Gilberto Lourenço Alves

Nomes de citação

  • Alves, Gilberto
  • Alves, G.
  • Alves, G.L.

Identificadores de autor

Ciência ID
BA10-57D6-DF00
Formação
Grau Classificação
2010 - 2013
Concluído
 Biomedicina (Pós-doutoramento)
Especialização em Biomedicina
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
 Aprovado
2008/10/01
Concluído
 Farmácia (Farmacologia) (Doutoramento)
Especialização em Farmacologia
Universidade de Coimbra Faculdade de Farmácia, Portugal
"Caracterização Farmacocinética do Acetato de Eslicarbazepina e dos Seus Metabolitos S-licarbazepina e R- Licarbazepina em Murganhos" (TESE/DISSERTAÇÃO)
 Approved with distinction and honors
2004/11/02 - 2004/11/12
Concluído
 III Course on Laboratory Animal Science (FELASA - LEVEL C) (Diploma de especialização)
Universidade de Lisboa - Faculdade de Medicina Veterinária, Portugal
2003/04/29
Concluído
 Ciências Farmacêuticas (Licenciatura)
Especialização em Não Aplicável
Universidade de Coimbra Faculdade de Farmácia, Portugal
"Não aplicável" (TESE/DISSERTAÇÃO)
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2009 - Atual Investigador (Investigação) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2023/05 - Atual Professor Associado (Docente Universitário) Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2009/07 - 2023/05 Professor Auxiliar (Docente Universitário) Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2008/10/01 - 2009/07 Professor Auxiliar Convidado (Docente Universitário) Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal

Cargos e Funções

Categoria Profissional
Instituição de acolhimento 		Empregador
2021/12 - Atual Diretor do Curso de Mestrado Integrado em Ciências Farmacêuticas (FCS-UBI) Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2017 - Atual Membro da Unidade de Farmacovigilância da Beira Interior Universidade da Beira Interior, Portugal
2010 - Atual Member of the Medicines Evaluation Board (Comissão de Avaliação de Medicamentos) Infarmed Autoridade Nacional do Medicamento e Produtos de Saúde IP, Portugal
2019/10 - 2021/02 Coordenador do Grupo de Investigação Biomedicinal Chemistry and Drug Research (BCDR) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2019 - 2021 Membro da Comissão Executiva do Centro de Investigação em Ciências da Saúde da Universidade da Beira Interior Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2010 - 2013 Pos-Doc Student Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2004 - 2008 PhD Student Universidade de Coimbra Faculdade de Farmácia, Portugal
Universidade de Coimbra Faculdade de Farmácia, Portugal
Projetos

Bolsa

Designação Financiadores
2019 - Atual Prunus avium L. vegetal parts and their bioactive properties in health and disease: What is the impact of the unexplored cherry byproducts?
SFRH/BD/139137/2018
Orientador
Fundação para a Ciência e a Tecnologia
Em curso
2019 - Atual Desenvolvimento de novos fármacos antiepiléticos: uma estratégia de hibridação da S-licarbazepina com compostos GABAérgicos
SFRH/BD/141900/2018
Orientador
Fundação para a Ciência e a Tecnologia
Em curso
2018 - Atual Novos azaesteroides modificados no anel D potencialmente úteis no tratamento do cancro e hiperplasia benigna da próstata
SFRH/BD/131059/2017
Orientador
Fundação para a Ciência e a Tecnologia
Em curso
2018 - Atual Avaliação farmacométrica da administração intranasal dos novos fármacos antiepiléticos perampanel, rufinamida, estiripentol e retigabina incorporados em (nano)formulações multi-funcionais
SFRH/BD/136028/2018
Orientador
Fundação para a Ciência e a Tecnologia
Em curso
2014 - Atual Pharmacometric evaluation of the anticonvulsant activity in electrical- and chemical-induced seizure models: Computational modelling and application in drug discovery
SFRH/BD/95505/2013
Orientador
Fundação para a Ciência e a Tecnologia
Em curso
2018/01 - 2018/10 Sweet cherries and vegetal parts as health promoters
BIPD/ICI-FCS/CICS/Santander Universidades-UBI/2017
Orientador
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
 Universidade da Beira Interior
Concluído
2014 - 2016 Bioanalytical tools for unraveling part of the puzzle of the biochemical phenomena in epilepsy: neuromediators and antiepileptic drugs
SFRH/BD/86496/2012
Orientador
Fundação para a Ciência e a Tecnologia
Concluído
2013 - 2016 Development of new antiepileptic drug candidates: a set of lamotrigine-related compounds
SFRH/BD/85279/2012
Orientador
Fundação para a Ciência e a Tecnologia
Concluído
2013 - 2016 Coadministration of antiepileptic drugs and P-glycoprotein inhibitors of flavonoid-type: A strategy to overcome the drug resistance in epilepsy
SFRH/BD/84936/2012
Orientador
Fundação para a Ciência e a Tecnologia
Concluído
2013 - 2016 Pharmacometric Evaluation of the Clinical Impact of Genetic Polymorphisms of the Cytochrome P450 and P-Glycoprotein in the Pharmacokinetics and Pharmacodynamics of Antidepressant Drugs: Fluoxetine, Paroxetine and Venlafaxine
SFRH/BD/85069/2012
Orientador
Fundação para a Ciência e a Tecnologia
Concluído
2014/04 - 2015/07 MicroRNA-124 loaded nanoparticles: boosting neurogenesis to treat Parkinson's disease
Provided by PTCRIS: 133846
EXPL/BIM-MED/0822/2013
Investigador
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.

Fundação para a Ciência e a Tecnologia, I.P.
Concluído
2012 - 2015 A Screening Strategy for Evaluation of Drug Transport across the Blood-Brain Barrier: Application to Catechol-O-methyltransferase Inhibitors, Dopamine ß-hydroxylase Inhibitors and Dibenz[b,f]azepine-5-carboxamide Derivatives
SFRH/BD/78256/2011
Orientador
Fundação para a Ciência e a Tecnologia
Concluído
2011 - 2014 Non-clinical Evaluation of the Pharmacokinetics and Pharmacodynamics of Opicapone, a Novel Catechol-O-methyltransferase Inhibitor
SFRH/BD/70918/2010
Orientador
Fundação para a Ciência e a Tecnologia
Concluído
2010 - 2014 Evaluation of Intranasal Administration of Fluoroquinolones and their Potential in the Treatment of Chronic Rhinosinusitis: Ciprofloxacin and Levofloxacin
SFRH/BD/69378/2010
Orientador
Fundação para a Ciência e a Tecnologia
Concluído
2010 - 2013 Caracterização do efeito de extratos de plantas usadas em programas de emagrecimento no perfil cinético de fármacos convencionais.
SFRH/BPD/46826/2008
Bolseiro de Pós-Doutoramento
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010 - 2013 Intranasal Delivery of Antiepileptic Drugs: Non-clinical Evaluation of Pharmacokinetics and Brain Biodistribution
SFRH/BD/64895/2009
Orientador
Fundação para a Ciência e a Tecnologia
Concluído
2009 - 2013 Evaluation of the effect of herbal extracts used in slimming regimens in the kinetic profile of narrow therapeutic range drugs used for cardiovascular pathologies: the amiodarone
SFRH/BD/61901/2009
Orientador
Fundação para a Ciência e a Tecnologia
Concluído
2004 - 2008 Caracterização Farmacocinética do Acetato de Eslicarbazepina e dos seus Metabolitos S-Licarbazepina e R-Licarbazepina em Murganhos
SFRH/BD/12694/2003
Bolseiro de Doutoramento
Universidade de Coimbra Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído

Projeto

Designação Financiadores
2020 - 2023 Centro de Investigação em Ciências da Saúde (UIDB/00709/2020)
UIDB/00709/2020
Investigador
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Em curso
2020 - 2023 Centro de Investigação em Ciências da Saúde (UIDP/00709/2020)
UIDP/00709/2020
Investigador
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2018/07/26 - 2021/07/25 Promoting the quality-of-life of epileptic patients through personalized medicine (4Epilepsy)
PTDC/SAL-SER/30478/2017
Investigador
Fundação para a Ciência e a Tecnologia
Em curso
2017/04 - 2020/12 ICON - Interdisciplinary Challenges On Neurodegeneration (Desafios Interdisciplinares em Neurodegeneração)
CENTRO-01-0145-FEDER-000013
Investigador
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
 Comissão de Coordenação e Desenvolvimento Regional do Centro
Em curso
2018/12 - 2020/08 C4 - Cloud Computing Competence Centre
C4 - Cloud Computing CompetenceCentre (C4-UBI)
Investigador
Comissão de Coordenação e Desenvolvimento Regional do Centro
Em curso
2017 - 2020 CMeC – Cereja do Fundão confitada com mel e carqueja como promotora da saúde
CENTRO-01-0247-FEDER-017547
Investigador
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Em curso
2019/01 - 2019/12 Centro de Investigação em Ciências da Saúde (UID/Multi/00709/2019)
UID/Multi/00709/2019
Investigador
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2015 - 2018 Project UID/Multi/00709/2013 – Centro de Investigação em Ciências da Saúde
POCI-01-0145-FEDER-007491
Investigador
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2013 - 2015 Therapeutic drug monitoring on age related diseases
CENTRO-07-ST24-FEDER-002012
Investigador
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
 Comissão de Coordenação e Desenvolvimento Regional do Centro
Concluído
2013 - 2015 Technologies for purification and controlled release of biopharmaceuticals to be applied in age-related diseases
CENTRO-07-ST24-FEDER-002014
Investigador
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
 Comissão de Coordenação e Desenvolvimento Regional do Centro
Concluído
2014/01 - 2014/12 Projeto Estratégico - UI 709 - 2014
PEst-OE/SAU/UI0709/2014
Investigador
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2011 - 2013 Projeto Estratégico - UI 709 - 2011-2012 (prolongado a 2013)
PEst-C/SAU/UI0709/2011
Investigador
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em revista
  1. Vanessa Brito; Mariana Marques; Marta Esteves; Catarina Serra-Almeida; Gilberto Alves; Paulo Almeida; Liliana Bernardino; Samuel Silvestre. "Synthesis, In Vitro Biological Evaluation of Antiproliferative and Neuroprotective Effects and In Silico Studies of Novel 16E-Arylidene-5a,6a-epoxyepiandrosterone Derivatives". Biomedicines (2023): https://doi.org/10.3390/biomedicines11030812.
    10.3390/biomedicines11030812
  2. Mariana Matias; Adriana O. Santos; Samuel Silvestre; Gilberto Alves. "Fighting Epilepsy with Nanomedicines—Is This the Right Weapon?". Pharmaceutics (2023): https://doi.org/10.3390/pharmaceutics15020306.
    10.3390/pharmaceutics15020306
  3. Ana C. Gonçalves; Fernando Sánchez-Juanes; Sara Meirinho; Luís R. Silva; Gilberto Alves; José David Flores-Félix. "Insight into the Taxonomic and Functional Diversity of Bacterial Communities Inhabiting Blueberries in Portugal". Microorganisms (2022): https://doi.org/10.3390/microorganisms10112193.
    10.3390/microorganisms10112193
  4. Ana R. Nunes; José D. Flores-Félix; Ana C. Gonçalves; Amílcar Falcão; Gilberto Alves; Luís R. Silva. "Anti-Inflammatory and Antimicrobial Activities of Portuguese Prunus avium L. (Sweet Cherry) By-Products Extracts". Nutrients (2022): https://doi.org/10.3390/nu14214576.
    10.3390/nu14214576
  5. Ana C. Gonçalves; Amílcar Falcão; Gilberto Alves; João A. Lopes; Luís R. Silva. "Employ of Anthocyanins in Nanocarriers for Nano Delivery: In Vitro and In Vivo Experimental Approaches for Chronic Diseases". Pharmaceutics (2022): https://doi.org/10.3390/pharmaceutics14112272.
    10.3390/pharmaceutics14112272
  6. Radhia Aitfella Lahlou; Nsevolo Samba; Pedro Soeiro; Gilberto Alves; Ana Carolina Gonçalves; Luís R. Silva; Samuel Silvestre; Jesus Rodilla; Maria Isabel Ismael. "Thymus hirtus Willd. ssp. algeriensis Boiss. and Reut: A Comprehensive Review on Phytochemistry, Bioactivities, and Health-Enhancing Effects". Foods (2022): https://doi.org/10.3390/foods11203195.
    10.3390/foods11203195
  7. Vanessa Brito; Adriana Oliveira Santos; Gilberto Alves; Paulo Almeida; Samuel Silvestre. "Novel 4-Azapregnene Derivatives as Potential Anticancer Agents: Synthesis, Antiproliferative Activity and Molecular Docking Studies". Molecules (2022): https://doi.org/10.3390/molecules27186126.
    10.3390/molecules27186126
  8. Sara Meirinho; Márcio Rodrigues; Adriana O. Santos; Amílcar Falcão; Gilberto Alves. "Self-Emulsifying Drug Delivery Systems: An Alternative Approach to Improve Brain Bioavailability of Poorly Water-Soluble Drugs through Intranasal Administration". Pharmaceutics (2022): https://doi.org/10.3390/pharmaceutics14071487.
    10.3390/pharmaceutics14071487
  9. Ana C. Gonçalves; Ana R. Nunes; José D. Flores-Félix; Gilberto Alves; Luís R. Silva. "Cherries and Blueberries-Based Beverages: Functional Foods with Antidiabetic and Immune Booster Properties". Molecules 27 10 (2022): 3294-3294. https://doi.org/10.3390/molecules27103294.
    10.3390/molecules27103294
  10. Ana R. Nunes; Fernando Sánchez-Juanes; Ana C. Gonçalves; Gilberto Alves; Luís R. Silva; José David Flores-Félix. "Evaluation of Raw Cheese as a Novel Source of Biofertilizer with a High Level of Biosecurity for Blueberry". Agronomy (2022): https://doi.org/10.3390/agronomy12051150.
    10.3390/agronomy12051150
  11. Ana C. Gonçalves; Dário Gaspar; José David Flores-Félix; Amílcar Falcão; Gilberto Alves; Luís R. Silva. "Effects of Functional Phenolics Dietary Supplementation on Athletes’ Performance and Recovery: A Review". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms23094652.
    10.3390/ijms23094652
  12. Catarina Canário; Mariana Matias; Vanessa Brito; Patrícia Pires; Adriana O. Santos; Amílcar Falcão; Samuel Silvestre; Gilberto Alves. "C-Ring Oxidized Estrone Acetate Derivatives: Assessment of Antiproliferative Activities and Docking Studies". Applied Sciences 12 7 (2022): 3579-3579. https://doi.org/10.3390/app12073579.
    10.3390/app12073579
  13. Cristina Monteiro; Samuel Silvestre; Ana Paula Duarte; Gilberto Alves. "Safety of Non-Steroidal Anti-Inflammatory Drugs in the Elderly: An Analysis of Published Literature and Reports Sent to the Portuguese Pharmacovigilance System". International Journal of Environmental Research and Public Health 19 6 (2022): 3541-3541. https://doi.org/10.3390/ijerph19063541.
    10.3390/ijerph19063541
  14. Ana Gonçalves; José Flores-Félix; Paula Coutinho; Gilberto Alves; Luís Silva. "Zimbro (Juniperus communis L.) as a Promising Source of Bioactive Compounds and Biomedical Activities: A Review on Recent Trends". International Journal of Molecular Sciences 23 6 (2022): 3197-3197. https://doi.org/10.3390/ijms23063197.
    10.3390/ijms23063197
  15. Patrícia C. Pires; Márcio Rodrigues; Gilberto Alves; Adriana O. Santos. "Strategies to Improve Drug Strength in Nasal Preparations for Brain Delivery of Low Aqueous Solubility Drugs". Pharmaceutics (2022):
    10.3390/pharmaceutics14030588
  16. Ana R. Nunes; Ana C. Gonçalves; Edgar Pinto; Filipa Amaro; José D. Flores-Félix; Agostinho Almeida; Paula Guedes de Pinho; et al. "Mineral Content and Volatile Profiling of Prunus avium L. (Sweet Cherry) By-Products from Fundão Region (Portugal)". Foods (2022): https://doi.org/10.3390/foods11050751.
    10.3390/foods11050751
  17. Canário C; Matias M; Brito V; Cruz-Vicente P; Soeiro P; Santos AO; Falcão A; Silvestre S; Alves G. "10ß-Hydroxyestra-1,4-diene-3,17-dione as potential antiproliferative agent: in vitro biological evaluation and in silico studies.". Natural product research (2022): http://europepmc.org/abstract/med/35167416.
    10.1080/14786419.2022.2039136
  18. Ana C. Gonçalves; Márcio Rodrigues; José David Flores-Félix; Gonçalo Campos; Ana R. Nunes; Alessandra Braga Ribeiro; Luís R. Silva; Gilberto Alves. "Sweet cherry phenolics revealed to be promising agents in inhibiting P-glycoprotein activity and increasing cellular viability under oxidative stress conditions: in vitro and in silico study". Journal of Food Science (2021): https://doi.org/10.1111/1750-3841.16001.
    10.1111/1750-3841.16001
  19. Silva S; Bicker J; Fonseca C; Ferreira NR; Vitorino C; Alves G; Falcão A; Fortuna A. "Encapsulated Escitalopram and Paroxetine Intranasal Co-Administration: In Vitro/In Vivo Evaluation.". Frontiers in pharmacology (2021): http://europepmc.org/abstract/med/34925013.
    10.3389/fphar.2021.751321
  20. Ana C. Gonçalves; Radhia Aitfella Lahlou; Gilberto Alves; Cristina Garcia-Viguera; Diego A. Moreno; Luís R. Silva. "Potential Activity of Abrantes Pollen Extract: Biochemical and Cellular Model Studies". Foods (2021): https://doi.org/10.3390/foods10112804.
    10.3390/foods10112804
  21. Ana C. Gonçalves; José D. Flores-Félix; Ana R. Costa; Amílcar Falcão; Gilberto Alves; Luís R. Silva. "Hepatoprotective Effects of Sweet Cherry Extracts (cv. Saco)". Foods (2021): https://doi.org/10.3390/foods10112623.
    10.3390/foods10112623
  22. Candeias C; Gama J; Rodrigues M; Falcão A; Alves G. "Potentially Inappropriate Medications and Potential Prescribing Omissions in Elderly Patients Receiving Post-Acute and Long-Term Care: Application of Screening Tool of Older People's Prescriptions/Screening Tool to Alert to Right Treatment Criteria.". Frontiers in pharmacology (2021): http://europepmc.org/abstract/med/34737705.
    10.3389/fphar.2021.747523
  23. Ana R. Nunes; Ana C. Gonçalves; Amílcar Falcão; Gilberto Alves; Luís R. Silva. "Prunus avium L. (Sweet Cherry) By-Products: A Source of Phenolic Compounds with Antioxidant and Anti-Hyperglycemic Properties—A Review". Applied Sciences 11 18 (2021): 8516-8516. https://doi.org/10.3390/app11188516.
    10.3390/app11188516
  24. José David Flores-Félix; Ana C. Gonçalves; Gilberto Alves; Luís R. Silva. "Consumption of Phenolic-Rich Food and Dietary Supplements as a Key Tool in SARS-CoV-19 Infection". Foods (2021): https://doi.org/10.3390/foods10092084.
    10.3390/foods10092084
  25. Catharine Falch; Gilberto Alves. "Pharmacists’ Role in Older Adults’ Medication Regimen Complexity: A Systematic Review". International Journal of Environmental Research and Public Health (2021): https://doi.org/10.3390/ijerph18168824.
    10.3390/ijerph18168824
  26. Ana C. Gonçalves; Ana R. Nunes; Amílcar Falcão; Gilberto Alves; Luís R. Silva. "Dietary Effects of Anthocyanins in Human Health: A Comprehensive Review". Pharmaceuticals 14 7 (2021): 690-690. https://doi.org/10.3390/ph14070690.
    10.3390/ph14070690
  27. Gonçalves AC; Campos G; Pinto E; Oliveira AS; Almeida A; de Pinho PG; Alves G; Silva LR. "Essential and non-essential elements, and volatile organic compounds for the discrimination of twenty-three sweet cherry cultivars from Fundão, Portugal.". Food chemistry (2021): http://europepmc.org/abstract/med/34352697.
    10.1016/j.foodchem.2021.130503
  28. Pires PC; Fazendeiro AC; Rodrigues M; Alves G; Santos AO. "Nose-to-brain delivery of phenytoin and its hydrophilic prodrug fosphenytoin combined in a microemulsion - formulation development and in vivo pharmacokinetics.". European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences (2021): http://europepmc.org/abstract/med/34174414.
    10.1016/j.ejps.2021.105918
  29. Ana R. Nunes; Ana C. Gonçalves; Gilberto Alves; Amílcar Falcão; Cristina Garcia-Viguera; Diego A. Moreno; Luís R. Silva. "Valorisation of Prunus avium L. By-Products: Phenolic Composition and Effect on Caco-2 Cells Viability". Foods 10 6 (2021): 1185-1185. https://doi.org/10.3390/foods10061185.
    10.3390/foods10061185
  30. Catarina Canário; Mariana Matias; Vanessa Brito; Adriana O. Santos; Amílcar Falcão; Samuel Silvestre; Gilberto Alves. "New Estrone Oxime Derivatives: Synthesis, Cytotoxic Evaluation and Docking Studies". Molecules (2021): https://doi.org/10.3390/molecules26092687.
    10.3390/molecules26092687
  31. José David Flores Félix; Fernando Sanchez-Juanes; Luis R. Silva; Gilberto Alves. "Metagenomic and Culturomic Approaches for Blueberry Biofertilizer Design". Biology and Life Sciences Forum (2021): https://doi.org/10.3390/IECAG2021-09668.
    10.3390/IECAG2021-09668
  32. Monteiro C; Silvestre S; Duarte AP; Alves G. "Assessment of suspected adverse drug reactions in elderly patients with diabetes mellitus based on a Portuguese spontaneous reporting database: analysis of reporting from 2008 to 2018.". Expert opinion on drug safety (2021): http://europepmc.org/abstract/med/33962523.
    10.1080/14740338.2021.1928072
  33. Vanessa Brito; Gilberto Alves; Paulo Almeida; Samuel Silvestre. "Highlights on Steroidal Arylidene Derivatives as a Source of Pharmacologically Active Compounds: A Review". Molecules 26 7 (2021): 2032-2032. https://doi.org/10.3390/molecules26072032.
    10.3390/molecules26072032
  34. Ana C. Gonçalves; Ana R. Nunes; Gilberto Alves; Luís R. Silva. "Serotonin and Melatonin: Plant Sources, Analytical Methods, and Human Health Benefits". Revista Brasileira de Farmacognosia (2021): https://doi.org/10.1007/s43450-021-00141-w.
    10.1007/s43450-021-00141-w
  35. Ana C. Gonçalves; Gonçalo Campos; Gilberto Alves; Cristina Garcia-Viguera; Diego A. Moreno; Luís R. Silva. "Physical and phytochemical composition of 23 Portuguese sweet cherries as conditioned by variety (or genotype)". Food Chemistry 335 (2021): 127637-127637. https://doi.org/10.1016/j.foodchem.2020.127637.
    10.1016/j.foodchem.2020.127637
  36. Joana Gonçalves; Soraia Silva; Filipa Gouveia; Joana Bicker; Amílcar Falcão; Gilberto Alves; Ana Fortuna. "A combo-strategy to improve brain delivery of antiepileptic drugs: Focus on BCRP and intranasal administration". International Journal of Pharmaceutics 593 (2021): 120161-120161. https://doi.org/10.1016/j.ijpharm.2020.120161.
    10.1016/j.ijpharm.2020.120161
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  3. Gonçalves, A.C.; Bento, C.; Jesus, F.; Alves, G.; Silva, L.R.. "Sweet Cherry Phenolic Compounds: Identification, Characterization, and Health Benefits". 31-78. 2018.
    10.1016/B978-0-444-64179-3.00002-5
  4. Alves, Gilberto. "Bioanalysis in drug discovery and development: Focus on pharmacokinetic studies". 191-210. 2011.
Livro
  1. Magalhães, M.; Ferreira, D.; Martinho, A.; Rosado, T.; Figueirinha, D.; Pires, A.; Domingues, F.; et al. Are naphthodianthrones the key molecules in the biological properties of hypericum perforatum?. 2017.
  2. Fortuna, A.; Alves, G.; Falcão, A.. Pharmacokinetics and bioanalysis to improve drug development. 2015.
    10.1515/9783110468755-003
  3. Fortuna, A.; Alves, G.; Falcão, A.. The pharmacology of simvastatin: From the mechanism of action to new therapeutic applications. 2015.
  4. Matias, M.; Canário, C.; Silvestre, S.; Falcã, A.; Alves, G.. Cytochrome P450-mediated toxicity of therapeutic drugs. 2014.
  5. Serralheiro, A.; Alves, G.; Sousa, J.; Fortuna, A.; Falcão, A.. Nose as a route for drug delivery. 2013.
    10.1007/978-3-642-37250-6_15
Pré-impressão
  1. Ana C. Gonçalves; Amícal Falcão; Gilberto Alves; João A. Lopes; Luís R. Silva. "Employ of Anthocyanins in nanocarriers for Nano Delivery: In Vitro and In Vivo Experimental Approaches for Chronic Diseases". 2022. https://doi.org/10.20944/preprints202210.0142.v1.
    10.20944/preprints202210.0142.v1
Tese / Dissertação
  1. Alves, Eunice Sofia Faria dos Santos. "Efeito do extrato de Paullinia cupana na farmacocinética da fenitoína em ratos Wistar". Mestrado, 2019. http://hdl.handle.net/10400.6/8924.
  2. Ventura, Sandra Cristina do Espírito Santo. "Nonclinical assessment of the potential for herb-drug interactions between herbal extracts present in weight loss supplements and lamotrigine". Doutoramento, 2019. http://hdl.handle.net/10400.6/6973.
  3. Fonseca, Beatriz Marques da. "Bioanalytical tools for unraveling part of the puzzle of the biochemical phenomena in epilepsy: neuromediators and antiepileptic drugs". Doutoramento, 2019. http://hdl.handle.net/10400.6/6966.
  4. Ferreira, Joana Giesteira. "Otimização de formulações termorreversíveis para administração nasal de carbamazepina". Mestrado, 2018. http://hdl.handle.net/10400.6/8747.
  5. Matias, Mariana Ruivo; Alves, Gilberto Lourenço; Silvestre, Samuel Martins; Ferreira, Amílcar Celta Falcão Ramos. "Development of new antiepileptic drug candidates: a set of lamotrigine-related compounds". Doutoramento, 2018. http://hdl.handle.net/10400.6/4769.
  6. Sousa, Joana Maria Ramalho de Almeida e; Ferreira, Amílcar Celta Falcão Ramos; Alves, Gilberto Lourenço. "Evaluation of intranasal administration of fluoroquinolones and their potential in the treatment of chronic rhinosinusitis: ciprofloxacin and levofloxacin". Doutoramento, 2018. http://hdl.handle.net/10316/42556.
  7. Aparício, Joana Bicker de Melo Alves; Falcão, Amílcar; Alves, Gilberto. "A Screening Strategy for Evaluation of Drug Transport across the Blood-Brain Barrier: Application to Catechol-O-methyltransferase Inhibitors, Dopamine ß-hydroxylase Inhibitors and Dibenz[b,f]azepine-5-carboxamide Derivatives". Doutoramento, 2018. http://hdl.handle.net/10316/42543.
  8. Ferreira, Ana Filipa da Silva; Alves, Gilberto Lourenço; Ferreira, Amílcar Celta Falcão Ramos. "Coadministration of antiepileptic drugs and P-glycoprotein inhibitors of flavonoid-type". Doutoramento, 2018. http://hdl.handle.net/10400.6/4775.
  9. Alves, Gilberto; Falcão, Amílcar; Gonçalves, Daniela de Oliveira. "Non-clinical Evaluation of the Pharmacokinetics and Pharmacodynamics of Opicapone, a Novel Catechol-O-methyltransferase Inhibitor". Doutoramento, 2017. http://hdl.handle.net/10316/79620.
  10. Amante, Pedro Miguel Lima Sobral. "Doença maníaco-depressiva: uma patologia psiquiátrica intrigante". Mestrado, 2017. http://hdl.handle.net/10400.6/7938.
  11. Ferreira, Paulo Renato da Silva. "Possibilidade de indução de cancro pelo tacrolímus". Mestrado, 2017. http://hdl.handle.net/10400.6/7937.
  12. Santos, Carmo Isabel Costa Fernandes Madaleno dos. "A funcionalização de esteroides com heterociclos no desenvolvimento de potenciais inibidores da glicoproteína-P". Mestrado, 2017. http://hdl.handle.net/10400.6/7949.
  13. Vicente, Nuno Tavares. "Caraterização sociodemográfica, clínica e farmacoterapêutica de doentes com epilepsia seguidos em consulta externa de neurologia". Mestrado, 2017. http://hdl.handle.net/10400.6/7936.
  14. Fernandes, Ana Cristina Moura Xavier. "Monitorização terapêutica de fármacos com base nos princípios de farmacocinética clínica". Mestrado, 2017. http://hdl.handle.net/10400.6/7929.
  15. Alves, Gilberto Lourenço; Ferreira, Ana Filipa da Silva; Gomes, Ana Inês Pacheco Vaz. "In vitro assessment of cytochrome P450 2C9 inhibition: tolbutamide as probe substrate and HepaRG cells as human hepatic model". Mestrado, 2016. http://hdl.handle.net/10400.6/5808.
  16. Rebelo, Ana Isabel Cunha; Alves, Gilberto Lourenço. "Alterações farmacocinéticas e suas implicações em estados de obesidade mórbida em adultos. Experiência Profissionalizante na vertente de Farmácia Comunitária, Hospitalar e Investigação". Mestrado, 2016. http://hdl.handle.net/10400.6/6282.
  17. Serralheiro, Ana Isabel Azevedo; Falcão, Amílcar; Alves, Gilberto. "Intranasal Delivery of Antiepileptic Drugs: Non-clinical Evaluation of Pharmacokinetics and Brain Biodistribution". Doutoramento, 2016. http://hdl.handle.net/10316/29482.
  18. Alves, Gilberto Lourenço; Pires, Benedita Nunes. "Necrólise epidérmica tóxica induzida por fármacos". Mestrado, 2015. http://hdl.handle.net/10400.6/4941.
  19. Alves, Gilberto Lourenço; Lopes, Ricardo José Castro Bastos. "Foto-onicólise induzida por fármacos: uma visão geral". Mestrado, 2015. http://hdl.handle.net/10400.6/5334.
  20. Alves, Gilberto Lourenço; Santos, Adriana; Santos, Rui Pedro da Silva. "Desenvolvimentos na administração intranasal de antipsicóticos: aspetos farmacêuticos, farmacocinéticos e farmacodinâmicos". Mestrado, 2015. http://hdl.handle.net/10400.6/5276.
  21. Alves, Gilberto Lourenço; Rodrigues, Márcio; Marques, Alexandre Emanuel Ramos. "Aplicação de MEPS em bioanálise de amostras de tecidos". Mestrado, 2015. http://hdl.handle.net/10400.6/5277.
  22. Alves, Gilberto Lourenço; Rodrigues, Márcio; Marvanejo, Patricia Sofia Draque. "Métodos cromatográficos para a quantificação de sondas da glicoproteína-P". Mestrado, 2015. http://hdl.handle.net/10400.6/5278.
  23. Alves, Gilberto Lourenço; Santos, Flávia Patrícia Andrade. "Estudo e caracterização dos hábitos de compra de medicamentos e suplementos online em Portugal". Mestrado, 2015. http://hdl.handle.net/10400.6/5280.
  24. Alves, Gilberto Lourenço; Serralheiro, Ana; Meirinho, Sara Alexandra. "Bioanalytical method validation of Venlafaxine and Desvenlafaxine in mouse plasma, brain and liver using a MEPS/HPLC assay: a path to study these drugs’ intranasal administration". Mestrado, 2015. http://hdl.handle.net/10400.6/6438.
  25. Almeida, Anabela Antunes de; Alves, Gilberto Lourenço; Ferreira, Teresa de Jesus Santos. "Reflexão sobre erros de medicação na aferição da qualidade dos Cuidados de Saúde". Mestrado, 2015. http://hdl.handle.net/10400.6/5043.
  26. Alves, Gilberto Lourenço; Mota, Nadine Freitas. "Análise do folheto informativo de medicamentos não sujeitos a receita médica para afeções comuns do trato gastrointestinal". Mestrado, 2015. http://hdl.handle.net/10400.6/5140.
  27. Ferreira, Maria João da Silva; Alves, Gilberto Lourenço. "Polimedicação em idosos institucionalizados". Mestrado, 2015. http://hdl.handle.net/10400.6/5328.
  28. Silva, Joana Madeira da; Alves, Gilberto Lourenço; Queimado, Sandra Isabel da Silva. "Operacionalização dos Critérios STOPP/START e sua Aplicação em Idosos sob Terapia Anticoagulante". Mestrado, 2015. http://hdl.handle.net/10400.6/5442.
  29. Nunes, Daniela Sofia Vieira; Alves, Gilberto Lourenço. "Evidência de efeitos cancerígenos e anticancerígenos associados à Amiodarona". Mestrado, 2015. http://hdl.handle.net/10400.6/5106.
  30. Moreira, Isabel Sofia Lourenço. "Desenvolvimento de uma solução autoemulsionante de fenitoína para administração oral". Mestrado, 2015. http://hdl.handle.net/10400.6/7168.
  31. Freitas, Sílvia Vanessa Spínola; Alves, Gilberto Lourenço. "Cardiotoxicidade induzida por fármacos". Mestrado, 2015. http://hdl.handle.net/10400.6/4983.
  32. Alves, Gilberto Lourenço; Agostinho, André Filipe Chambel. "Caracterização do perfil de consumo de ansiolíticos, sedativos e hipnóticos na Beira Interior". Mestrado, 2014. http://hdl.handle.net/10400.6/5144.
  33. Alves, Gilberto Lourenço; Castelo-Branco, Miguel; Pousinho, Sarah Jane. "Deteção e análise de casos de nefrotoxicidade induzida por fármacos ou outras substâncias medicinais". Mestrado, 2014. http://hdl.handle.net/10400.6/4984.
  34. Alves, Gilberto Lourenço; Serra, António Luís; Tomás, Carina Alexandra Gomes. "Aplicação dos critérios STOPP/START a idosos diabéticos em Cuidados de Saúde Primários". Mestrado, 2014. http://hdl.handle.net/10400.6/5047.
  35. Alves, Gilberto Lourenço; Silvestre, Samuel Martins; Esteves, Davide Miguel Pires. "Antidiabéticos orais: perfil de utilização, efeitos secundários e interações medicamentosas". Mestrado, 2014. http://hdl.handle.net/10400.6/5055.
  36. Gonçalves, Miguel Ângelo Lopes; Alves, Gilberto; Santos, Adriana Oliveira dos. "Modelos ex-vivo para avaliação da permeação de fármacos pelas vias nasal e rectal – revisão sistemática". Mestrado, 2014. http://hdl.handle.net/10400.6/6413.
  37. Diogo, Carla Alexandra Santos; Alves, Gilberto Lourenço. "Interações farmacológicas envolvendo a glicoproteína-P: o caso particular da digoxina". Mestrado, 2014. http://hdl.handle.net/10400.6/4876.
  38. Santos, João Pedro Ladeira; Alves, Gilberto Lourenço. "Inibição da glicoproteína-P: modelos celulares para ensaios de screening in vitro". Mestrado, 2014. http://hdl.handle.net/10400.6/5142.
  39. Santos, Sara Catarina Gomes Coelho dos; Alves, Gilberto Lourenço. "Caracterização da utilização de medicamentos em idosos residentes em lares através da aplicação dos critérios de Beers". Mestrado, 2014. http://hdl.handle.net/10400.6/5134.
  40. Alves, Gilberto Lourenço; Cardoso, Raquel Guilherme. "Avaliação do uso de medicamentos potencialmente inapropriados em idosos institucionalizados em lares : aplicação dos Critérios de Beers". Mestrado, 2013. http://hdl.handle.net/10400.6/1632.
  41. Rodrigues, Márcio José de Abreu Marques; Falcão, Amílcar; Alves, Gilberto Lourenço. "Evaluation of the effect of herbal extracts used in slimming regimens in the kinetic profile of narrow therapeutic range drugs used for cardiovascular pathologies: the amiodarone". Doutoramento, 2013. http://hdl.handle.net/10316/24327.
  42. Martins, Ana Isabel Figueiredo; Alves, Gilberto Lourenço; Falcão, Amílcar. "Determinação fluorimétrica da rodamina 123 em plasma de rato: ferramenta para a avaliação in vivo da actividade da glicoproteína-P". Mestrado, 2010. http://hdl.handle.net/10400.6/3948.
  43. Alves, Gilberto Lourenço; Falcão, Amílcar; Figueiredo, Isabel Vitória. "Caracterização farmacocinética do acetato de eslicarbazepina e dos seus metabolitos S-licarbazepina e R-licarbazepina em murganhos". Doutoramento, 2008. http://hdl.handle.net/10316/5945.

Outros

Outra produção
  1. Anti-Inflammatory and Antiproliferative Properties of Sweet Cherry Phenolic-Rich Extracts. Molecules. 2021. Ana C. Gonçalves; Ana R. Costa; José D. Flores-Félix; Amílcar Falcão; Gilberto Alves; Luís Manuel Lopes Rodrigues da Silva; Gonçalves, Ana C.; et al. https://doi.org/10.20944/preprints202112.0263.v1.
    10.20944/preprints202112.0263.v1
  2. Influence of the dual combination of silymarin and (-)-epigallocatechin gallate, natural dietary flavonoids, on the pharmacokinetics of oxcarbazepine in rats. Considering the potential of flavonoids in reversing the P-glycoprotein (P-gp)–mediated multidrug resistance, this work aimed to assess the combined effects of silymarin and (-)-epigallocatechin gallate (EPG) on the pharmacokinetics of the P-gp substrates oxcarbazepine (OXC) and licarbazepine (LIC). Rats were pre-treated intraperitoneally with silymarin (25 mg/kg), EPG (25 mg/kg), silymarin/EPG (1. 2017. Ferreira, Ana; Rodrigues, Márcio; Marques, Alexandre; Falcão, Amílcar; Alves, Gilberto; Ferreira, A.; Rodrigues, M.; et al. http://hdl.handle.net/10314/3720.
    10.1016/j.fct.2017.06.015
  3. Flavonoid compounds as reversing agents of the P-glycoprotein-mediated multidrug resistance: An in vitro evaluation with focus on antiepileptic drugs. The pharmacoresistance to antiepileptic drugs (AEDs) remains a major unsolved therapeutic need. The overexpression of multidrug transporters, as the P-glycoprotein (P-gp), at the level of the blood-brain barrier of epileptic patients has been suggested as a key mechanism underlying the refractory epilepsy. Thus, efforts have been made to search for therapeutically useful P-gp inhibitors. Herein, t. 2017. Ferreira, Ana; Rodrigues, Márcio; Fortuna, Ana; Falcão, Amílcar; Alves, Gilberto; Ana, Ferreira; Márcio, Rodrigues; et al. http://hdl.handle.net/10314/3945.
    10.1016/j.foodres.2017.10.010
  4. Determination of catecholamines and endogenous related compounds in rat brain tissue exploring their native fluorescence and liquid chromatography. The profiling analysis of catecholamines and their metabolites in brain tissue offers a crucial key to understand their functions in the body and the opportunity to follow up neural diseases. A rapid and simple liquid chromatography-fluorescence detection (LC-FLD) method was developed and validated for simultaneously measuring several catecholamines and endogenous related compounds in the rat brai. 2017. Fonseca, Beatriz; Rodrigues, Márcio; Cristóvão, Ana; Gonçalves, Daniela; Fortuna, Ana; Bernardino, Liliana; Falcão, Amílcar; et al. http://hdl.handle.net/10314/3607.
    10.1016/j.jchromb.2017.02.028
  5. A Rapid and Sensitive HPLC–DAD Assay to Quantify Lamotrigine, Phenytoin and Its Main Metabolite in Samples of Cultured HepaRG Cells. A sensitive and fast high-performance liquid chromatography-diode-array detection assay was developed and validated for the simultaneous quantification of 5-(4-hydroxyphenyl)-5-phenylhydantoin (HPPH), phenytoin (PHT) and lamotrigine (LTG) in samples of cultured HepaRG cells. Chromatographic separation of analytes and internal standard (IS) was achieved in ~15 min on a C18-column, at 35°C, using ac. 2016. Ferreira, Ana; Rodrigues, Márcio; Falcão, Amílcar; Alves, Gilberto; Ferreira, A.; Rodrigues, M.; Falcão, A.; Alves, G.. http://hdl.handle.net/10314/3101.
    10.1093/chromsci/bmw088
  6. An easy-to-use liquid chromatography assay for the analysis of lamotrigine in rat plasma and brain samples using microextraction by packed sorbent:Application to a pharmacokinetic study. A simple and rapid high-performance liquid chromatography method with diode-array detection (HPLC-DAD) using microextraction by packed sorbent (MEPS) during the sample preparation step was developed and validated to quantify lamotrigine (LTG) in rat plasma and brain samples. MEPS variables such as pH, number of draw-eject cycles, and washing and desorption conditions were optimized. The chromatogr. 2016. Ventura, Sandra; Rodrigues, Márcio; Pousinho, Sarah; Falcão, Amílcar; Alves, Gilberto; Ventura, S.; Rodrigues, M.; et al. http://hdl.handle.net/10314/3099.
    10.1016/j.jchromb.2016.09.032
  7. Development and application of an ex vivo fosphenytoin nasal bioconversion/permeability evaluation method. There is an increasing interest in the intranasal delivery of central nervous system-active drugs due to the existence of a direct nose-to-brain connection. However, poor solubility limits the amount of drug that can be administered within an aqueous solution. In the present work, the objectives were to develop an ex vivo bioconversion/ permeability evaluation method and to study the ex vivo bioco. 2016. Viegas, Daniel Antunes; Rodrigues, Márcio; Francisco, Joana; Falcão, Amílcar; Alves, Gilberto; Santos, Adriana O.; Antunes Viegas, D.; et al. http://hdl.handle.net/10314/3103.
    10.1016/j.ejps.2016.04.018
  8. Pharmacokinetics, brain distribution and plasma protein binding of carbamazepine and nine derivatives: new set of data for predictive in silico ADME models. In silico approaches to predict absorption, distribution, metabolism and excretion (ADME) of new drug candidates are gaining a relevant importance in drug discovery programmes. When considering particularly the pharmacokinetics during the development of oral antiepileptic drugs (AEDs), one of the most prominent goals is designing compounds with good bioavailability and brain penetration. Thus, it. 2013. Fortuna, Ana; Alves, Gilberto; Soares-da-Silva, Patrício; Falcão, Amílcar; Fortuna, A.; Alves, G.; Soares-da-Silva, P.; Falcão, A.. http://hdl.handle.net/10316/27421.
    10.1016/j.eplepsyres.2013.08.013
Atividades

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2016 - 2016 Alterações farmacocinéticas e suas implicações em estados de obesidade mórbida em adultos. Experiência Profissionalizante na vertente de Farmácia Comunitária, Hospitalar e Investigação Ciências Farmacêuticas (Mestrado)
Universidade da Beira Interior, Portugal
2016 - 2016 In vitro assessment of cytochrome P450 2C9 inhibition: tolbutamide as probe substrate and HepaRG cells as human hepatic model Química Medicinal (Mestrado)
Universidade da Beira Interior, Portugal
2015 - 2015 Cardiotoxicidade induzida por fármacos Experiência Profissionalizante na vertente de Farmácia Comunitária, Hospitalar e Investigação Ciências Farmacêuticas (Mestrado)
Universidade da Beira Interior, Portugal
2015 - 2015 Necrólise epidérmica tóxica induzida por fármacos Experiência Profissionalizante na vertente de Farmácia Comunitária, Hospitalar e Investigação Ciências Farmacêuticas (Mestrado)
Universidade da Beira Interior, Portugal
2015 - 2015 Análise do folheto informativo de medicamentos não sujeitos a receita médica para afeções comuns do trato gastrointestinal Experiência Profissionalizante na vertente de Farmácia Comunitária, Farmácia Hospitalar e Investigação Ciências Farmacêuticas (Mestrado)
Universidade da Beira Interior, Portugal
2015 - 2015 Evidência de efeitos cancerígenos e anticancerígenos associados à Amiodarona Experiência Profissionalizante na vertente de Farmácia Comunitária e Investigação Ciências Farmacêuticas (Mestrado)
Universidade da Beira Interior, Portugal
2015 - 2015 Polimedicação em Idosos Institucionalizados Experiência Profissionalizante na vertente de Farmácia Comunitária, Hospitalar e Investigação Ciências Farmacêuticas (Mestrado)
Universidade da Beira Interior, Portugal
2015 - 2015 Desenvolvimentos na administração intranasal de antipsicóticos: aspetos farmacêuticos, farmacocinéticos e farmacodinâmicos Experiência Profissionalizante na vertente de Farmácia Comunitária e Investigação Ciências Farmacêuticas (Mestrado)
Universidade da Beira Interior, Portugal
2015 - 2015 Aplicação de MEPS em bioanálise de amostras de tecidos Experiência Profissionalizante na vertente de Farmácia Comunitária e Investigação Ciências Farmacêuticas (Mestrado)
Universidade da Beira Interior, Portugal
2015 - 2015 Métodos cromatográficos para a quantificação de sondas da glicoproteína-P Experiência Profissionalizante na vertente de Farmácia Comunitária, Hospitalar e Investigação Ciências Farmacêuticas (Mestrado)
Universidade da Beira Interior, Portugal
2015 - 2015 Estudo e caracterização dos hábitos de compra de medicamentos e suplementos online em Portugal Experiência Profissionalizante na vertente de Farmácia Comunitária e Investigação Ciências Farmacêuticas (Mestrado)
Universidade da Beira Interior, Portugal
2015 - 2015 Bioanalytical method validation of Venlafaxine and Desvenlafaxine in mouse plasma, brain and liver using a MEPS/HPLC assay: a path to study these drugs’ intranasal administration Experiência Profissionalizante na vertente de Farmácia Comunitária, Hospitalar e Investigação Ciências Farmacêuticas (Mestrado)
Universidade da Beira Interior, Portugal
2015 - 2015 Foto-onicólise induzida por fármacos: Uma visão geral Experiência Profissionalizante na vertente de Farmácia Comunitária e Investigação Ciências Farmacêuticas (Mestrado)
Universidade da Beira Interior, Portugal
2015 - 2015 Operacionalização dos Critérios STOPP/START e sua Aplicação em Idosos sob Terapia Anticoagulante - Experiência Profissionalizante na vertente de Farmácia Comunitária, Hospitalar e Investigação Ciências Farmacêuticas (Mestrado)
Universidade da Beira Interior, Portugal
2014 - 2014 Interações farmacológicas envolvendo a glicoproteína-P: o caso particular da digoxina Experiência profissionalizante na vertente de farmácia comunitária, farmácia hospitalar e investigação Ciências Farmacêuticas (Mestrado)
Universidade da Beira Interior, Portugal
2014 - 2014 Caracterização da utilização de medicamentos em idosos residentes em lares através da aplicação dos critérios de Beers Experiência Profissionalizante na vertente de Investigação, Farmácia Hospitalar e Comunitária Ciências Farmacêuticas (Mestrado)
Universidade da Beira Interior, Portugal
2014 - 2014 Deteção e análise de casos de nefrotoxicidade induzida por fármacos ou outras substâncias medicinais Experiência Profissionalizante na vertente de Farmácia Comunitária, Hospitalar e Investigação Ciências Farmacêuticas (Mestrado)
Universidade da Beira Interior, Portugal
2014 - 2014 Aplicação dos Critérios STOPP/START a Idosos Diabéticos em Cuidados de Saúde Primários Experiência Profissionalizante na vertente de Farmácia Comunitária e Investigação Ciências Farmacêuticas (Mestrado)
Universidade da Beira Interior, Portugal
2014 - 2014 Inibição da glicoproteína-P: modelos celulares para ensaios de screening in vitro Experiência Profissionalizante na Vertente de Farmácia Comunitária, Hospitalar e Investigação Ciências Farmacêuticas (Mestrado)
Universidade da Beira Interior, Portugal
2014 - 2014 Caracterização do perfil de consumo de ansiolíticos, sedativos e hipnóticos na Beira Interior Experiência Profissionalizante na vertente de Farmácia Comunitária, Hospitalar e Investigação Ciências Farmacêuticas (Mestrado)
Universidade da Beira Interior, Portugal
2013 - 2013 Coadministration of antiepileptic drugs and P-glycoprotein inhibitors of flavonoid-type: a strategy to overcome the drug resistance in epilepsy Ciências Farmacêuticas (Doutoramento)
Universidade da Beira Interior, Portugal
2013 - 2013 Avaliação do uso de medicamentos potencialmente inapropriados em idosos institucionalizados em lares: aplicação dos Critérios de Beers Experiência Profissionalizante na Vertente de Farmácia Comunitária Ciências Farmacêuticas (Mestrado)
Universidade da Beira Interior, Portugal
2013 - 2013 Development of new antiepileptic drug candidates: a set of lamotrigine-related compounds Ciências Farmacêuticas (Doutoramento)
Universidade da Beira Interior, Portugal
2012 - 2012 Bioanalytical tools for unraveling part of the puzzle of the biochemical phenomena in epilepsy: neuromediators and antiepileptic drugs Bioquímica (Doutoramento)
Universidade da Beira Interior, Portugal
2011 - 2011 Avaliação do potencial de interacção entre extratos de plantas usados em produtos de emagrecimento e a lamotrigina Bioquímica (Doutoramento)
Universidade da Beira Interior, Portugal
2009 - 2009 Evalution of the Effedt of Herbal Extracts used in slimming Regimens in the Kinetic Profile of Narrow Therapeutic Range Drugs used for Cardiovacular Pathologies: the Amiodarone Farmácia (Doutoramento)
Universidade de Coimbra Faculdade de Farmácia, Portugal

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2019/10 - 2021/02 Membro da Comissão Executiva do Centro de Investigação em Ciências da Saúde da Universidade da Beira Interior
Membro
2019/10 - 2021/02 Coordenador do Grupo de Investigação Biomedicinal Chemistry and Drug Research (BCDR) do Centro de Investigação em Ciências da Saúde da Universidade da Beira Interior
Coordenador
Distinções

Outra distinção

2015 LPCE 2015 Award
2014 Best Poster Award
2012 LPCE 2012 Award
2012 Poster Award: "Pharmacokinetic interaction of Paullinia cupana extract and amiodarone in rat"
2012 Poster award: "Interação entre os extratos de Fucus vesiculosus e de Paullinia cupana com a amiodarona em ratos"
2008 Honorable Mention
2003 Merit Scholarship
2002 Merit Scholarship