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Dr. Ana Cláudia Lima has a post-doc research position under the scope of the 2MATCH project, at 3B's Research Group, since September 2020. She concluded her master’s degree in Pharmaceutical Sciences at the Faculty of Pharmacy of the University of Porto in 2013. She received her PhD in Tissue Engineering, Regenerative Medicine, and Stem Cells, with high academic distinction from 3Bs Research Group - University of Minho in 2020. During her PhD studies, she developed 3 novel nanomedicines to treat autoimmune/inflammatory conditions, which significantly contributed to the state-of-art of nanotechnology field, as revealed by the number of high-quality publications as the first author: 5 original papers (3 published in IF>7, Acs Appl Mater Inter, Adv Healthc Mater, J Control Release, 2 submitted), 1 review and 2 issued patents. She has a FELASA category C certification for animal experiments. Dr. Ana Lima has a broad scientific interdisciplinary expertise in the fields of nanotechnology, immunology, cellular/molecular biology, pharmacology, drug delivery, bioengineering, material science, biomaterials, tissue engineering, microfluidics, biosensors, and microfabrication. As a result of her research work, Dr. Ana C. Lima’s is the (co-)author of 10 full papers in Q1 score International journals (4 published, 6 submitted), 2 reviews (1 published, 1 submitted), and 2 issued patents. Considering the important role of her work in the field, she has attended several important national and international meetings with 5 oral presentations and 6 poster communications, being very active in engaging the public dissemination of the work. Her work has been cited around 59 times and has an h-index of 3 (Google Scholar). She has also been involved in the writing or active research in several national and international R&D research projects. During these years of research career, Dr. Ana C. Lima was granted with 2 fellowships and 1 grant from FCT (Incentivo/SAU/LA0026/2014, PD/BD/11384/2015, and PTDC/BTM-ORG/28070/2017) and 1 grant for research internship (H2020 MSCA RISE 2017 REMIX). In parallel, she has/d an active role in student supervision/mentoring, including more than 5 MSc/PhD students. She is also a referee in scientific journals and has been part of the organizing committees of conferences (eg TERM STEM conferences). To foster fruitful collaborations with different universities, she enrolled in 2 secondments at the Strathclyde Institute of Pharmacy and Biomedical Sciences in Glasgow, United Kingdom, and at the Faculty of Engineering in Chulalongkorn University, Bangkok, Thailand. Her personal and professional goals and ambitions make Dr. Ana C. Lima eager to embrace challenges and deliver research work at the highest standards levels, which is underscored by several scientific publications, presentations, and patents.
Identificação

Identificação pessoal

Nome completo
Ana Cláudia Fernandes Lima

Nomes de citação

  • Lima, Ana Cláudia
  • Lima, Ana C.

Identificadores de autor

Ciência ID
BD17-C41C-4297
ORCID iD
0000-0002-9102-6235

Endereços de correio eletrónico

  • aclaudialima2@gmail.com (Pessoal)

Domínios de atuação

  • Ciências Médicas e da Saúde - Biotecnologia Médica - Biotecnologia Aplicada à Saúde
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Biomateriais
  • Ciências da Engenharia e Tecnologias - Nanotecnologia
  • Ciências da Engenharia e Tecnologias - Outras Ciências da Engenharia e Tecnologias - Outras áreas das Engenharias e Tecnologias
  • Ciências Médicas e da Saúde - Medicina Básica - Farmacologia e Farmácia
  • Ciências Naturais - Ciências Biológicas - Biologia Molecular

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C2) Utilizador proficiente (C1) Utilizador proficiente (C2) Utilizador proficiente (C1)
Espanhol; Castelhano Utilizador elementar (A1) Utilizador independente (B2) Utilizador elementar (A2) Utilizador independente (B1) Utilizador elementar (A2)
Francês Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1)
Formação
Grau Classificação
2015/09/01 - 2020/02/20
Concluído
Tissue Engineering, Regenerative Medicine and Stem Cells (Doutoramento)
Universidade do Minho, Portugal
"Nanoparticles for advanced treatments of arthritic diseases" (TESE/DISSERTAÇÃO)
Muito bom (maximum grade)
2018/01/29 - 2018/02/09
Concluído
Animal Sciences Laboratory Category C (Diploma de especialização)
Especialização em Experiências animais
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
17/20
2008/09/02 - 2013/12/03
Concluído
Pharmaceutical Sciences (Mestrado)
Universidade do Porto Faculdade de Farmácia, Portugal
"Cancer and Herpes Simplex virus treatment" (TESE/DISSERTAÇÃO)
15/20
Percurso profissional

Ciência

2020/09/02 - Atual Pós-doutorado (Investigação)
Universidade do Minho, Portugal
2019/09/05 - 2019/12/05 Investigador visitante (Investigação)
Chulalongkorn University, Tailândia
2015/04/06 - 2015/08/31 Investigador (Investigação)
Universidade do Minho, Portugal
2013/01/30 - 2013/05/03 Estagiário de Investigação (Investigação)
Strathclyde Institute for Pharmacy & Biomedical Sciences - Univesity of Strathclyde, Reino Unido

Outros

2015/09/01 - 2020/02/20 PhD Student
Universidade do Minho, Portugal
2014/04/16 - 2015/04/05 Pharmacist
Farmácia Vitória, Portugal
Projetos

Bolsa

Designação Financiadores
2017 - 2019/12/05 Regenerative Medicine Innovation Crossing - Research and Innovation Staff Exchange inRegenerative Medicine
info:eu-repo/grantAgreement/EC/H2020/778078/EU
Chulalongkorn University, Tailândia
European Commission
2015 - 2019/09/01 PD/BD/11384/2015
PD/BD/11384/2015
Bolseiro de Doutoramento
Biomaterials Biodegradables and Biomimetics, Portugal

Laboratório Associado ICVS 3B's, Portugal
Fundação para a Ciência e a Tecnologia
2015 - 2015/08/31 Incentivo/SAU/LA0026/2014
Incentivo/SAU/LA0026/2014
Bolseiro de Investigação
Biomaterials Biodegradables and Biomimetics, Portugal

Laboratório Associado ICVS 3B's, Portugal
Fundação para a Ciência e a Tecnologia

Projeto

Designação Financiadores
2020 - Atual 2MATCH - Modelling cancer Metastasis into the humAn microcirculation system using a mulTiorgan- on-a-CHip approach
PTDC/BTM-ORG/28070/2017
Investigador Pós-doutorado
Biomaterials Biodegradables and Biomimetics, Portugal

Laboratório Associado ICVS 3B's, Portugal
Fundação para a Ciência e a Tecnologia

Outro

Designação Financiadores
2018 - Atual Cells4_IDs - Cell-based therapy for the treatment of articular inflammatory diseases
PTDC/BTM-SAL/28882/2017
Investigador
Biomaterials Biodegradables and Biomimetics, Portugal

Laboratório Associado ICVS 3B's, Portugal
Fundação para a Ciência e a Tecnologia
2016 - Atual Frontiers of technology for theranostics of cancer, metabolic and neurodegenerative diseases (FROnTHERA)
NORTE-01-0145-FEDER-000023
Investigador
Biomaterials Biodegradables and Biomimetics, Portugal

Laboratório Associado ICVS 3B's, Portugal
NORTE 2020
2017 - 2019/11/01 SPARTAN - Preclinical Validation of a TNF-Capturing Device as Therapeutics of Inflammatory Arthritic Diseases
PTDC/CTM-BIO/4388/2014
Investigador
Biomaterials Biodegradables and Biomimetics, Portugal

Laboratório Associado ICVS 3B's, Portugal
Fundação para a Ciência e a Tecnologia
Produções

Publicações

Artigo em conferência
  1. Lima, Ana Cláudia; Campos, Cláudia F.; Cunha, Cristina; Carvalho, Agostinho; Reis, Rui L.; Ferreira, Helena; Neves, Nuno M.. "IL-23 inactivation by targeted liposomes to mediate the regression of autoimmune diseases". Trabalho apresentado em TERMIS-EU 2019, Rhodes, 2019.
    Publicado
  2. Lima, Ana Cláudia; Amorim, Diana; Laranjeira, Inês; Almeida, Armando; Ferreira, Helena; Pinto-Ribeiro, Filipa; Neves, Nuno M.. "Neutralization of Pro-inflammatory Cytokines by Intra-articular Injection of Biofunctionalized Nanoparticles as an Advanced Treatment for Osteoarthritis". Trabalho apresentado em TERMIS-EU 2019, Rhodes, 2019.
    Publicado
  3. Lima, Ana Cláudia; Cunha, Cristina; Carvalho, Agostinho; Ferreira, Helena; Neves, Nuno M.. "Advanced treatment for arthritic diseases based on the capture and inactivation of interleukin-6 by biofunctionalized polymeric nanoparticles". Trabalho apresentado em TERMIS-EU 2017, Davos, 2017.
    Publicado
  4. Lima, Ana Cláudia; Lynne Braidwood; Kirsty Learmonth; Edmond Y.W. Chan; Joe Conner. "Autophagy in human cancer cell lines during infection with ICP34.5-deleted oncolytic HSV1716". Trabalho apresentado em 8th International Conference on Oncolytic Virus Therapeutics, Oxford, 2014.
    Publicado
Artigo em revista
  1. Lima, Ana Cláudia; Amorim, Diana; Laranjeira, Inês; Almeida, Armando; Reis, Rui L.; Ferreira, Helena; Pinto-Ribeiro, Filipa; Neves, Nuno M.. "Modulating inflammation through the neutralization of Interleukin-6 and tumor necrosis factor-a by biofunctionalized nanoparticles". Journal of Controlled Release 331 (2021): 491-502. http://dx.doi.org/10.1016/j.jconrel.2021.02.001.
    10.1016/j.jconrel.2021.02.001
  2. Lima, Ana Cláudia; Reis, Rui L.; Ferreira, Helena; Neves, Nuno M.. "Cellular Uptake of Nanoparticles in an Inflammatory Arthritis Scenario". Molecular Pharmaceutics (2021):
    Em revisão
  3. Lima, Ana Cláudia; Reis, Rui L.; Ferreira, Helena; Neves, Nuno M.. "Glutathione reductase-sensitive Polymeric Micelles for Controlled Drug Delivery on Arthritic Diseases". ACS Biomaterials Science & Engineering (2021):
    Em revisão
  4. Lima, Ana Cláudia. "A biocompatible and injectable hydrogel to facilitate and potentiate the neurodegenerative diseases treatment". (2021):
    Submetido
  5. Lima, Ana Cláudia. "Microfluidic Electrospinning, an alternative to Coaxial, as a dual drug release system to treat inflammatory arthritic diseases". Small (2021):
    Submetido
  6. Lima, Ana Cláudia. "Precision biomaterials in cancer research". Progress in Biomedical Engineering (2021):
    Em revisão
  7. Lima, Ana Cláudia. "Evaluation of the potential of sardine roe-derived liposomes as bioactive drug delivery systems using an in vivo model of arthritis". (2021):
    Submetido
  8. Lima, Ana Cláudia. "Development of thin membranes from eggshell membrane as an innovative biomaterial for biomedical applications". (2021):
    Submetido
  9. Lima, Ana Cláudia; Campos, Cláudia F.; Cunha, Cristina; Carvalho, Agostinho; Reis, Rui L.; Ferreira, Helena; Neves, Nuno M.. "Biofunctionalized Liposomes to Monitor Rheumatoid Arthritis Regression Stimulated by Interleukin-23 Neutralization". Advanced Healthcare Materials 10 2 (2020): 2001570. http://dx.doi.org/10.1002/adhm.202001570.
    Publicado • 10.1002/adhm.202001570
  10. Lima, Ana Cláudia; Ferreira, Helena; Reis, Rui L.; Neves, Nuno M.. "Biodegradable polymers: an update on drug delivery in bone and cartilage diseases". Expert Opinion on Drug Delivery 16 8 (2019): 795-813. http://dx.doi.org/10.1080/17425247.2019.1635117.
    Publicado • 10.1080/17425247.2019.1635117
  11. Lima, Ana Cláudia; Cunha, Cristina; Carvalho, Agostinho; Ferreira, Helena; Neves, Nuno M.. "Interleukin-6 Neutralization by Antibodies Immobilized at the Surface of Polymeric Nanoparticles as a Therapeutic Strategy for Arthritic Diseases". ACS Applied Materials & Interfaces 10 16 (2018): 13839-13850. http://dx.doi.org/10.1021/acsami.8b01432.
    Publicado • 10.1021/acsami.8b01432
  12. Cunha, S.C.; Faria, M.A.; Pereira, V.L.; Oliveira, T.M.; Lima, A.C.; Pinto, E.. "Patulin assessment and fungi identification in organic and conventional fruits and derived products". Food Control 44 (2014): 185-190. http://dx.doi.org/10.1016/j.foodcont.2014.03.043.
    Publicado • 10.1016/j.foodcont.2014.03.043
Poster em conferência
  1. Lima, Ana Cláudia; Amorim, Diana; Laranjeira, Inês; Almeida, Armando; Reis, Rui L.; Ferreira, Helena; Pinto-Ribeiro, Filipa; Neves, Nuno M.. "A dual targeting strategy using antibodies immobilized at the surface of biodegradable nanoparticles for local osteoarthritis treatment". Trabalho apresentado em Achilles 2019, 2019.
  2. Lima, Ana Cláudia; Amorim, Diana; Laranjeira, Inês; Almeida, Armando; Reis, Rui L.; Ferreira, Helena; Pinto-Ribeiro, Filipa; Neves, Nuno M.. "Neutralization of Pro-inflammatory Cytokines by Intra-articular Injection of Biofunctionalized Nanoparticles as an Advanced Treatment for Osteoarthritis". Trabalho apresentado em Society for Biomaterials Annual Meeting and Exposition 2019, 2019.
  3. Lima, Ana Cláudia; Amorim, Diana; Almeida, Armando; Reis, Rui L.; Ferreira, Helena; Pinto-Ribeiro, Filipa; Neves, Nuno M.. "Intra-articular injection of biofunctionalized nanoparticles to neutralize Interleukin-6 and Tumour Necrosis Factor-a to treat osteoarthritis". Trabalho apresentado em Gene2Skin / Chem2Nature Final Conferences, Guimarães, 2018.
  4. Lima, Ana Cláudia; Cunha, Cristina; Carvalho, Agostinho; Ferreira, Helena; Neves, Nuno M.. "Capture and neutralization of interleukin-6 by the intra-articular injection of biofunctionalized polymeric nanoparticles as advanced treatment for arthritic diseases". Trabalho apresentado em Chem2Nature / Gene2Skin, 2018.
  5. Lima, Ana Cláudia; Amorim, Diana; Almeida, Agostinho; Reis, Rui L.; Ferreira, Helena; Pinto-Ribeiro, Filipa; Neves, Nuno M.. "Interleukin-6 and Tumour Necrosis Factor-a neutralization by biofunctionalized nanoparticles after intra-articular injection for osteoarthritis treatment". Trabalho apresentado em TERM STEM 2017, 2017.
  6. Lima, Ana Cláudia; Cunha, Cristina; Carvalho, Agostinho; Ferreira, Helena; Neves, Nuno M.. "Biofunctionalized polymeric nanoparticles for a prolonged and local capture of pro-inflammatory cytokines in arthritic joints". Trabalho apresentado em TERM STEM 2016, 2016.
    10.1136/annrheumdis-2018-eular.2581
Tese / Dissertação
  1. Lima, Ana Cláudia. "Nanoparticles for advanced treatments of arthritic diseases". Doutoramento, Universidade do Minho, 2020.
  2. Lima, Ana Cláudia. "Cancer and Herpes Simplex virus treatment". Mestrado, Universidade do Porto Faculdade de Farmácia, 2013.

Propriedade Intelectual

Pedido provisório de patente
  1. 2019. "Polymeric micelle, methods of production and uses thereof".
    Protegido
  2. 2019. "Phosphatidylcholine liposomes, methods and uses thereof".
    Protegido
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2019/05/27 Pro-inflammatory Cytokines neutralization by intra-articular injection of biofunctionalized nanoparticles as advanced treatment for osteoarthritis. TERMIS-EU 2019
(Rhodes, Grécia)
2019/05/27 IL-23 inactivation by targeted liposomes to mediate the regression of autoimmune diseases. TERMIS-EU 2019
(Rhodes, Grécia)
2017/06/02 Capture and neutralization of interleukin-6 by the intra-articular injection of biofunctionalized polymeric nanoparticles as advanced treatment for arthritic diseases. Chem2Nature 2017
(Porto, Portugal)
2017/05/26 Advanced treatment for arthritic diseases based on the capture and inactivation of interleukin-6 by biofunctionalized polymeric nanoparticles. TERMIS - EU 2017
(Davos, Suiça)
2014/04/13 Autophagy in human cancer cell lines during infection with ICP34.5-deleted oncolytic HSV1716 8th International Conference on Oncolytic Virus Therapeutics, 2014
(Oxford, Reino Unido)

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação)
Instituição / Organização
2017/11/13 - Atual Organization committee of TermStem conferences (2017/11/13)
Conferência (Membro da Comissão Organizadora)
Biomaterials Biodegradables and Biomimetics, Portugal

Participação em evento

Descrição da atividade
Tipo de evento
Nome do evento
Instituição / Organização
2021/01/11 - 2021/01/20 On-line participation
Seminário
REMIX Seminar Series 2021 on Tissue Engineering and Regenerative Medicine
Università degli Studi di Trento, Itália

Universidade do Minho, Portugal
2020/03 - 2020/06 On-line attendance of different courses from Coursera.
Seminário
"Fundamentals of Immunology: Innate Immunity and B-Cell Function" "Fundamentals of Immunology: T Cells and Signaling"
Rice University, Estados Unidos
2020/02/13 - 2020/02/13 Event participation
Seminário
EIT Health Accelerator Info Session
Biomaterials Biodegradables and Biomimetics, Portugal
2019/07/11 - 2019/07/12 Event participation/Poster presentation
Conferência
Forecast/Achilles, Porto
2019/05/27 - 2019/05/31 Event participation/Oral presentation
Conferência
TERMIS EU, 2019, Rhodes, Greece
2019/05/08 - 2019/05/08 Event participation
Oficina (workshop)
Workshop Translational science in musculoskeletal disorders, Guimarães
2018/10/23 - 2018/10/26 Event participation/Poster presentation
Conferência
Gene2Skin / Chem2Nature Final Conferences, Guimarães
2018/09/12 - 2018/09/12 Participation with a scientific photo in the photo context "Uma Visão Dinâmica da Ciência"
Concurso
"Uma Visão Dinâmica da Ciência"
Biomaterials Biodegradables and Biomimetics, Portugal
2018/06/03 - 2018/06/06 Event participation/Poster presentation
Conferência
Chem2Nature / Gene2Skin, Porto
2017/11/13 - 2017/11/17 Event participation/poster presentation
Conferência
GENE2SKIN Winter School / TERM STEM / FORECAST, Porto
2017/06 - 2017/06 Event participation/Oral presentation
Conferência
Chem2Nature 2017, Porto, Portugal
2017/05/26 - 2017/05/30 Event participation/Oral presentation
Conferência
TERMIS EU 2017, Davos, Switzerland
2017/01/23 - 2017/01/24 Participation in "1st Chem2Nature Workshop"
Oficina (workshop)
1st Chem2Nature Workshop
Coventry University, Reino Unido
2016/10/26 - 2016/10/27 Event participation/poster presentation
Conferência
TERM STEM 2016, Guimarães
2015/04 - 2015/04 Participation in V ICVS/3Bs Meeting
Encontro
ICVS/3Bs Meeting
Laboratório Associado ICVS 3B's, Portugal
2014/04/11 - 2014/04/13 Event participation/Oral presentation
Conferência
8th International Conference on Oncolytic Virus Therapeutics, 2014
2011/09 - 2011/09 Participation in VII edition of "Young European Scientist Meeting"
Encontro
Young European Scientist Meeting
Universidade do Porto, Portugal
2010/09 - 2010/10 Participation in VI edition of "Young European Scientist Meeting"
Encontro
Young European Scientist Meeting
Universidade do Porto, Portugal
2007/06 - 2007/06 Participation in the Science Competition "Jovens Cientistas e Investigadores"
Concurso
Jovens Cientistas e Investigadores

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2021/01/01 - Atual Journal of Healthcare Engineering (2040-2309) Hindawi Publishing Corporation

Membro de associação

Nome da associação Tipo de participação
2017/06/01 - Atual Tissue Engineering and Regenerative Medicine International Society (TERMIS) Membership

Tutoria

Tópico Nome do aluno
2021/01/01 - Atual PhD Student - University of Minho (Nanoparticles internalization) Sara Gimondi
2020/11/01 - Atual PhD Student - University of Minho (Nanoparticles internalization) Daniel Mendanha
2020/08/01 - 2020/11/30 MSc in Biomedical Engineering - University of Minho (Cell Culture) Filipa Vasconcelos
2019/07/01 - 2019/09/01 PhD Student - University of Minho (In vivo studies) Marta Guedes
2018/01/01 - 2018/06/01 PhD Student - University of Minho (Cell culture) Sara Vieira
Distinções

Prémio

2008 Honors Diploma (High School)
2007 Honorable Mention in the Science Competition "Jovens Cientistas e Investigadores"

Título

2020 PhD degree in Tissue Engineering, Regenerative Medicine and Stem Cells
Universidade do Minho, Portugal

Biomaterials Biodegradables and Biomimetics, Portugal
2013 Master degree in Pharmaceutical Sciences
Universidade do Porto Faculdade de Farmácia, Portugal

Outra distinção

2006 First Certificate in English - ESOL Examinations
University of Cambridge Language Centre, Reino Unido