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Paula Agostinho (PA) is graduated in Biology and got a PhD degree in Cell Biology in 1998 from Coimbra University (UC), Faculty of Science and Technology, Portugal. Currently, she is Principal Investigator (with tenure) at the Faculty of Medicine at UC (FMUC), and is Principal Investigator at the Center for Neuroscience and Cell Biology (CNC), which integrates the Center for Innovative Biomedicine and Biotechnology (CIBB), an Associated Laboratory (top 100% score) at UC. PA has participated in the research team of 15 projects funded by either FCT (Portuguese agency) or other international agencies, being PI or Co-PI of three of these projects. Her research is mainly focused on studying the cellular and molecular mechanisms related to neurodegenerative disorders, such as Alzheimer´s, Parkinson´s, and Prion´s diseases, and also stress-related disorders, with a particular focus in aspects related with astrocyte-neuron communication operated by the purinergic system. P.Agostinho (or PM Agostinho) published 87 papers in peer-reviewed journals, the majority in international quartile 1 (Q1) journals, and have also more than 12 published abstracts in journals. The scientific impact of her research is reflected in the H index (41) and high number of citations (> 4900), being senior/corresponding author of 20 papers, and has a global "Category Normalized Citation Impact (CNCI)" of 1.67 values, according to WoScc Web of Science, which means her publications are 1.67 times more cited than the world average. The most representative areas of its publications are: i) "Neurosciences" (62 publications) where the CNCI is 1.62 values, and ii) Pharmacology & Pharmacy (11 publications) with a CNCI value of 2.61. It has a publication in the Top 1% (PNAS 2015) of the most cited and 25 publications in the Top10% of the most cited, in the aforementioned areas, as well as a publication in (Science 2021), with a CNCI value of 99.89, therefore Top 1% in the Multidisciplinary Sciences area. She supervised several PhD (4 concluded, 2 ongoing) and Master (15 concluded) students, research fellows, UC 1st cycle, and ERASMUS students, having also be enrolled in Master and PhD programs at UC as lecturer or member of organizing committee, thesis evaluation. Furthermore, she teaches (1st cycle) integrated masters in Medicine and Biomedical Engineering (UC). PA participated in the organization of XV Portuguese Neuroscience Meeting (2001) and of V Symposium of Portuguese Glial Network (2021), and was invited speaker and/or co-authored more than 66 oral and 220 poster communications in (inter)national scientific meetings. P. Agostinho was Guest Editor of a special issue of Frontiers of Neuroscience "Adenosinergic System and Central Nervous System Disorders (2021) and of Journal of Alzheimer´s disease, also act as a reviewer of several journals( e.g. FASEB J, Eur J. Neurosci, Aging Cell) and has integrated the evaluation board of funding agencies of the Czech Republic, Polony and Italy. In addition, she participated in some science outreach projects and activities, namely "Ciencia Viva during Summer Holidays" and "Brain Awareness Week", and was invited to participate in events in media and broad end-users (TV, radio, newspapers).
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Identificação

Identificação pessoal

Nome completo
PAULA MARIA GARCIA AGOSTINHO

Nomes de citação

  • Agostinho, Paula
  • Paula M Agostinho

Identificadores de autor

Ciência ID
CB17-DF58-E952
ORCID iD
0000-0001-5523-4945
Researcher Id
F-3748-2010
Scopus Author Id
57295664700

Endereços de correio eletrónico

  • pagostinho@fmed.uc.pt (Profissional)

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B2)
Português (Idioma materno)
Formação
Grau Classificação
1998
Concluído
 Biologia Celular (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Efeito do "stress" oxidativo nos mecanismos que regulam a libertação de neurotransmissores nas células da retina em cultura"" (TESE/DISSERTAÇÃO)
 Aprovação por unanimidade com distinção e louvor
1990
Concluído
 Biologia (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
 14 valores
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2024/05/09 - Atual Investigador principal (carreira) (Investigação) Universidade de Coimbra Faculdade de Medicina, Portugal
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
1999/02/19 - 2024/05/08 Investigador Auxiliar (carreira) (Investigação) Universidade de Coimbra Faculdade de Medicina, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
1998/02/01 - Atual Principal Investigator (non-remunerated) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
1998/10/01 - 1999/01/31 Postdoctoral fellowship (PRAXISXXI grant#IBPD/1663/98), awarded by the Portuguese Foundation for Science and Technology (FCT)) Fundação para a Ciência e a Tecnologia, Portugal
1992/11/01 - 1996/11/30 PhD fellowships grant# BD/2105/94-ID (1992-1994); and PRAXIS XXI grant# /BD/5288/95 (1995-1996)) Fundação para a Ciência e a Tecnologia, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
1990/11/01 - 1991/12/31 Master's scholarship (grant# BM/591/90-ID), awarded by the Junta Nacional de Investigação Científica e Tecnológica (JNICT) Fundação para a Ciência e a Tecnologia, Portugal
Projetos

Bolsa

Designação Financiadores
2010/04 - 2014/11 New treatments for stress-induced dysregulation of circuits regulating reward, fear, and habit learning
DARPA-BAA-009-68
 Defense Advanced Research Projects Agency Defense Sciences Office
2012/04 - 2014/09 Role of accumbens and amygdala in the control of chronic stress neuropathology
Provided by PTCRIS: 122254
122254
 Fundação para a Ciência e a Tecnologia, I.P.
2011/08 - 2013/12 Localization and metabolism of APP controlling synaptic degeneration in animal models of Alzheimer's disease
114810
Provided by PTCRIS: 114810
 Fundação para a Ciência e a Tecnologia, I.P.
2010/03 - 2012/09 Role of ATP and its P2Y1 receptors in neuroprotection
Provided by PTCRIS: 100423
100423
 Fundação para a Ciência e a Tecnologia, I.P.
2010/03 - 2012/02 Role of adenosine A2A receptors in microglia and glutamatergic synapses in the control of synaptic plasticity and brain damage
108668
Provided by PTCRIS: 108668
 Fundação para a Ciência e a Tecnologia, I.P.
2007/08 - 2011/07 Design, synthesis and biological assessment of multifunctional compounds as anti-Alzheimer drugs
Provided by PTCRIS: 64151
64151
 Fundação para a Ciência e a Tecnologia, I.P.

Projeto

Designação Financiadores
2019/10/01 - 2021/09/30 Adenosine A2A receptors as a new opportunity to manage and detail the neurobiology of emotional distress
La Caixa HR17-00523
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 LaCaixa Foundation
Em curso
2018/07/01 - 2021/06/30 Adenosine A2A receptors as triggers of memory dysfunction in Alzheimer's disease: mechanisms and therapeutic prospects
PTDC/MED-NEU/31274/2017
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2016/05 - 2019/10 Role of astrocytes on the control of memory-focus on adenosine A2A receptors
PTDC/NEU-NMC/4154/2014
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Ministério da Ciência, Tecnologia e Ensino Superior
Concluído
2013/07 - 2015/11 Transcriptome, epigenome and proteome dysregulation in human circuits regulating reward, fear, and habit learning
DARPA-BAA-10-55
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Defense Advanced Research Projects Agency Defense Sciences Office
Concluído
2012/05 - 2014/08 Physiopathological role of ecto-5`-nucleotidase - a new target for neuroprotection
122005
Provided by PTCRIS: 122005
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
Concluído
Produções

Publicações

Artigo em revista
  1. Ana Carla L. Nunes; Marta Carmo; Andrea Behrenswerth; Paula M. Canas; Paula Agostinho; Rodrigo A. Cunha. "Adenosine A2A Receptor Blockade Provides More Effective Benefits at the Onset Rather than after Overt Neurodegeneration in a Rat Model of Parkinson’s Disease". International Journal of Molecular Sciences (2024): https://doi.org/10.3390/ijms25094903.
    10.3390/ijms25094903
  2. Daniela Madeira; Joana Domingues; Cátia R. Lopes; Paula M. Canas; Rodrigo A. Cunha; Paula Agostinho. "Modification of astrocytic Cx43 hemichannel activity in animal models of AD: modulation by adenosine A2A receptors". Cellular and Molecular Life Sciences (2023): https://doi.org/10.1007/s00018-023-04983-6.
    10.1007/s00018-023-04983-6
  3. Daniela Madeira; Cátia R. Lopes; Ana P. Simões; Paula M. Canas; Rodrigo A. Cunha; Paula Agostinho. "Astrocytic A2A receptors silencing negatively impacts hippocampal synaptic plasticity and memory of adult mice". Glia (2023): https://doi.org/10.1002/glia.24384.
    10.1002/glia.24384
  4. Liliana Dias; Daniela Madeira; Rafael Dias; Ângelo R. Tomé; Rodrigo A. Cunha; Paula Agostinho. "Aß1-42 peptides blunt the adenosine A2A receptor-mediated control of the interplay between P2X7 and P2Y1 receptors mediated calcium responses in astrocytes". Cellular and Molecular Life Sciences (2022): https://doi.org/10.1007/s00018-022-04492-y.
    10.1007/s00018-022-04492-y
  5. Daniela Madeira; Liliana Dias; Patrícia Santos; Rodrigo A. Cunha; Paula Agostinho; Paula M. Canas. "Adenosine A2A receptors blockade attenuates dexamethasone-induced alterations in cultured astrocytes". Purinergic Signalling (2022): https://doi.org/10.1007/s11302-022-09864-4.
    10.1007/s11302-022-09864-4
  6. Cátia R. Lopes; Inês M. Amaral; Marlene F. Pereira; João P. Lopes; Daniela Madeira; Paula M. Canas; Rodrigo A. Cunha; Paula Agostinho. "Impact of blunting astrocyte activity on hippocampal synaptic plasticity in a mouse model of early Alzheimer's disease based on amyloid-ß peptide exposure". Journal of Neurochemistry (2022): https://doi.org/10.1111/jnc.15575.
    10.1111/jnc.15575
  7. Agostinho, Paula. "Convergence of adenosine and GABA signaling for synapse stabilization during development". Science 374 6568 (2021): http://dx.doi.org/10.1126/science.abk2055.
    10.1126/science.abk2055
  8. Daniela Madeira; Liliana Dias; Patrícia Santos; Rodrigo A. Cunha; Paula M. Canas; Paula Agostinho. "Association Between Adenosine A2A Receptors and Connexin 43 Regulates Hemichannels Activity and ATP Release in Astrocytes Exposed to Amyloid-ß Peptides". Molecular Neurobiology (2021): https://doi.org/10.1007/s12035-021-02538-z.
    10.1007/s12035-021-02538-z
  9. Marlene F. Pereira; Inês M. Amaral; Cátia Lopes; Catarina Leitão; Daniela Madeira; João P. Lopes; Francisco Q. Gonçalves; et al. "l -a-aminoadipate causes astrocyte pathology with negative impact on mouse hippocampal synaptic plasticity and memory". The FASEB Journal 35 8 (2021): https://doi.org/10.1096/fj.202100336R.
    10.1096/fj.202100336R
  10. Agostinho, Paula. "Astrocytes and Adenosine A2A Receptors: Active Players in Alzheimer’s Disease". Frontiers in Neuroscience 15 (2021): http://dx.doi.org/10.3389/fnins.2021.666710.
    10.3389/fnins.2021.666710
  11. Dias, Liliana; Lopes, Cátia R.; Gonçalves, Francisco Q.; Nunes, Ana; Pochmann, Daniela; Machado, Nuno J.; Tomé, Angelo R.; Agostinho, Paula; Cunha, Rodrigo A.. "Crosstalk Between ATP-P2X7 and Adenosine A2A Receptors Controlling Neuroinflammation in Rats Subject to Repeated Restraint Stress". Frontiers in Cellular Neuroscience 15 (2021): http://dx.doi.org/10.3389/fncel.2021.639322.
    Publicado • 10.3389/fncel.2021.639322
  12. Speck, Ana E.; Aguiar, Aderbal S.; Ferreira, Samira G.; Silva, Henrique B.; Tomé, Angelo R.; Agostinho, Paula; Cunha, Rodrigo A.; Prediger, Rui D.. "Exercise decreases aberrant corticostriatal plasticity in an animal model of L-DOPA-induced dyskinesia". American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (2021): http://dx.doi.org/10.1152/ajpregu.00295.2020.
    10.1152/ajpregu.00295.2020
  13. Paula Agostinho; Daniela Madeira; Liliana Dias; Ana Patrícia Simões; Rodrigo A. Cunha; Paula M. Canas. "Purinergic signaling orchestrating neuron-glia communication". Pharmacological Research (2020): 105253-105253. https://doi.org/10.1016/j.phrs.2020.105253.
    10.1016/j.phrs.2020.105253
  14. Silva, Daniel; Mendes, Eduarda; Summers, Eleanor J.; Neca, Ana; Jacinto, Ana C.; Reis, Telma; Agostinho, Paula; et al. "Synthesis, biological evaluation, and molecular modeling of nitrile-containing compounds: Exploring multiple activities as anti-Alzheimer agents". Drug Development Research 81 2 (2020): 215-231. http://dx.doi.org/10.1002/ddr.21594.
    10.1002/ddr.21594
  15. Gonçalves, Francisco Q.; Lopes, João P.; Silva, Henrique B.; Lemos, Cristina; Silva, António C.; Gonçalves, Nélio; Tomé, Ângelo R.; et al. "Synaptic and memory dysfunction in a ß-amyloid model of early Alzheimer's disease depends on increased formation of ATP-derived extracellular adenosine". Neurobiology of Disease 132 (2019): 104570. http://dx.doi.org/10.1016/j.nbd.2019.104570.
    10.1016/j.nbd.2019.104570
  16. Agostinho, Paula. "Enhanced ATP release and CD73-mediated adenosine formation sustain adenosine A2A receptor over-activation in a rat model of Parkinson's disease.". British journal of pharmacology (2019): https://doi.org/10.1111/bph.14771.
    10.1111/bph.14771
  17. Canas, P.M.; Porciúncula, L.O.; Simões, A.P.; Augusto, E.; Silva, H.B.; Machado, N.J.; Gonçalves, N.; et al. "Neuronal adenosine A2A receptors are critical mediators of neurodegeneration triggered by convulsions". eNeuro 5 6 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85059796352&partnerID=MN8TOARS.
    10.1523/ENEURO.0385-18.2018
  18. Silva, A.C.; Lemos, C.; Gonçalves, F.Q.; Pliássova, A.V.; Machado, N.J.; Silva, H.B.; Canas, P.M.; et al. "Blockade of adenosine A2A receptors recovers early deficits of memory and plasticity in the triple transgenic mouse model of Alzheimer's disease". Neurobiology of Disease 117 (2018): 72-81. http://www.scopus.com/inward/record.url?eid=2-s2.0-85048494541&partnerID=MN8TOARS.
    10.1016/j.nbd.2018.05.024
  19. Amorim, J.A.; Canas, P.M.; Tomé, A.R.; Rolo, A.P.; Agostinho, P.; Palmeira, C.M.; Cunha, R.A.. "Mitochondria in Excitatory and Inhibitory Synapses have Similar Susceptibility to Amyloid-ß Peptides Modeling Alzheimer's Disease". Journal of Alzheimer's Disease 60 2 (2017): 525-536. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029613373&partnerID=MN8TOARS.
    10.3233/JAD-170356
  20. Carvalho, F.B.; Gutierres, J.M.; Bueno, A.; Agostinho, P.; Zago, A.M.; Vieira, J.; Frühauf, P.; et al. "Anthocyanins control neuroinflammation and consequent memory dysfunction in mice exposed to lipopolysaccharide". Molecular Neurobiology 54 5 (2017): 3350-3367. http://www.scopus.com/inward/record.url?eid=2-s2.0-84966705153&partnerID=MN8TOARS.
    10.1007/s12035-016-9900-8
  21. Machado, N.J.; Simões, A.P.; Silva, H.B.; Ardais, A.P.; Kaster, M.P.; Garção, P.; Rodrigues, D.I.; et al. "Caffeine Reverts Memory But Not Mood Impairment in a Depression-Prone Mouse Strain with Up-Regulated Adenosine A2A Receptor in Hippocampal Glutamate Synapses". Molecular Neurobiology 54 2 (2017): 1552-1563. http://www.scopus.com/inward/record.url?eid=2-s2.0-84957698500&partnerID=MN8TOARS.
    10.1007/s12035-016-9774-9
  22. Moidunny, S.; Matos, M.; Wesseling, E.; Banerjee, S.; Volsky, D. J.; Cunha, R. A.; Agostinho, P.; Boddeke, H. W.; Roy, S.. "Oncostatin M is a potential therapeutic target in HIV-associated neuronal excitotoxicity". Journal of NeuroImmune Pharmacology (2017): https://publons.com/wos-op/publon/6042064/.
  23. Rial, D.; Lemos, C.; Pinheiro, H.; Duarte, J.M.; Gonçalves, F.Q.; Real, J.I.; Prediger, R.D.; et al. "Depression as a glial-based synaptic dysfunction". Frontiers in Cellular Neuroscience 9 JAN2016 (2016): 1-11. http://www.scopus.com/inward/record.url?eid=2-s2.0-84957876863&partnerID=MN8TOARS.
    10.3389/fncel.2015.00521
  24. Köfalvi, A.; Lemos, C.; Martín-Moreno, A.M.; Pinheiro, B.S.; García-García, L.; Pozo, M.A.; Valério-Fernandes, Â.; et al. "Stimulation of brain glucose uptake by cannabinoid CB2 receptors and its therapeutic potential in Alzheimer's disease". Neuropharmacology 110 (2016): 519-529. http://www.scopus.com/inward/record.url?eid=2-s2.0-84988025899&partnerID=MN8TOARS.
    10.1016/j.neuropharm.2016.03.015
  25. Moidunny, S.; Matos, M.; Wesseling, E.; Banerjee, S.; Volsky, D.J.; Cunha, R.A.; Agostinho, P.; Boddeke, H.W.; Roy, S.. "Oncostatin M promotes excitotoxicity by inhibiting glutamate uptake in astrocytes: Implications in HIV-associated neurotoxicity". Journal of Neuroinflammation 13 1 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84973515337&partnerID=MN8TOARS.
    10.1186/s12974-016-0613-8
  26. Pliássova, A.; Lopes, J.P.; Lemos, C.; Oliveira, C.R.; Cunha, R.A.; Agostinho, P.. "The Association of Amyloid-ß Protein Precursor With a- and ß-Secretases in Mouse Cerebral Cortex Synapses Is Altered in Early Alzheimer’s Disease". Molecular Neurobiology 53 8 (2016): 5710-5721. http://www.scopus.com/inward/record.url?eid=2-s2.0-84945268204&partnerID=MN8TOARS.
    10.1007/s12035-015-9491-9
  27. Pliassova, A.; Canas, P.; Xavier, A.; Da Silva, B.; Cunha, R.; Agostinho, P.; Pliássova, A.; et al. "Age-related changes in the synaptic density of amyloid-beta protein precursor and secretases in the human cerebral cortex". European Neuropsychopharmacology 52 4 (2016): 1209-1214. https://publons.com/wos-op/publon/6042072/.
    10.1016/S0924-977X(16)31773-4
  28. Matos, M.; Shen, H.-Y.; Augusto, E.; Wang, Y.; Wei, C.J.; Wang, Y.T.; Agostinho, P.; et al. "Deletion of Adenosine A2A Receptors from Astrocytes Disrupts Glutamate Homeostasis Leading to Psychomotor and Cognitive Impairment: Relevance to Schizophrenia". Biological Psychiatry 78 11 (2015): 763-774. http://www.scopus.com/inward/record.url?eid=2-s2.0-84957928612&partnerID=MN8TOARS.
    10.1016/j.biopsych.2015.02.026
  29. Agostinho, P.; Pliássova, A.; Oliveira, C.R.; Cunha, R.A.. "Localization and Trafficking of Amyloid-ß Protein Precursor and Secretases: Impact on Alzheimer's Disease". Journal of Alzheimer's Disease 45 2 (2015): 329-347. http://www.scopus.com/inward/record.url?eid=2-s2.0-84925344255&partnerID=MN8TOARS.
    10.3233/JAD-142730
  30. Kaster, M.P.; Machado, N.J.; Silva, H.B.; Nunes, A.; Ardais, A.P.; Santana, M.; Baqi, Y.; et al. "Caffeine acts through neuronal adenosine A2A receptors to prevent mood and memory dysfunction triggered by chronic stress". Proceedings of the National Academy of Sciences of the United States of America 112 25 (2015): 7833-7838. http://www.scopus.com/inward/record.url?eid=2-s2.0-84934894606&partnerID=MN8TOARS.
    10.1073/pnas.1423088112
  31. Travassos, M.; Santana, I.; Baldeiras, I.; Tsolaki, M.; Gkatzima, O.; Genc, S.; Yener, G.G.; et al. "Does Caffeine Consumption Modify Cerebrospinal Fluid Amyloid-ß Levels in Patients with Alzheimer's Disease?". Journal of Alzheimer's Disease 47 4 (2015): 1069-1078. http://www.scopus.com/inward/record.url?eid=2-s2.0-84939450783&partnerID=MN8TOARS.
    10.3233/JAD-150374
  32. Gutierres, J.M.; Carvalho, F.B.; Schetinger, M.R.C.; Agostinho, P.; Marisco, P.C.; Vieira, J.M.; Rosa, M.M.; et al. "Neuroprotective effect of anthocyanins on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia in rats". International Journal of Developmental Neuroscience 33 1 (2014): 88-97. http://www.scopus.com/inward/record.url?eid=2-s2.0-84892473219&partnerID=MN8TOARS.
    10.1016/j.ijdevneu.2013.12.006
  33. Garção, P.; Oliveira, C.R.; Cunha, R.A.; Agostinho, P.. "Subsynaptic localization of nicotinic acetylcholine receptor subunits: A comparative study in the mouse and rat striatum". Neuroscience Letters 566 (2014): 106-110. http://www.scopus.com/inward/record.url?eid=2-s2.0-84896142912&partnerID=MN8TOARS.
    10.1016/j.neulet.2014.02.018
  34. Gutierres, J.M.; Carvalho, F.B.; Schetinger, M.R.C.; Marisco, P.; Agostinho, P.; Rodrigues, M.; Rubin, M.A.; et al. "Anthocyanins restore behavioral and biochemical changes caused by streptozotocin-induced sporadic dementia of Alzheimer's type". Life Sciences 96 1-2 (2014): 7-17. http://www.scopus.com/inward/record.url?eid=2-s2.0-84892799447&partnerID=MN8TOARS.
    10.1016/j.lfs.2013.11.014
  35. Salamone, A.; Zappettini, S.; Grilli, M.; Olivero, G.; Agostinho, P.; Tomé, A.R.; Chen, J.; et al. "Prolonged nicotine exposure down-regulates presynaptic NMDA receptors in dopaminergic terminals of the rat nucleus accumbens". Neuropharmacology 79 (2014): 488-497. http://www.scopus.com/inward/record.url?eid=2-s2.0-84892589518&partnerID=MN8TOARS.
    10.1016/j.neuropharm.2013.12.014
  36. Rodrigues, D.I.; Gutierres, J.; Pliássova, A.; Oliveira, C.R.; Cunha, R.A.; Agostinho, P.. "Synaptic and sub-synaptic localization of amyloid-ß protein precursor in the rat hippocampus". Journal of Alzheimer's Disease 40 4 (2014): 981-992. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901755722&partnerID=MN8TOARS.
    10.3233/JAD-132030
  37. Rial, D.; Pamplona, F.A.; Moreira, E.L.G.; Moreira, K.M.; Hipolide, D.; Rodrigues, D.I.; Dombrowski, P.A.; et al. "Cellular prion protein is present in dopaminergic neurons and modulates the dopaminergic system". European Journal of Neuroscience 40 3 (2014): 2479-2486. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905364655&partnerID=MN8TOARS.
    10.1111/ejn.12600
  38. Lopes, J.P.; Oliveira, C.R.; Agostinho, P.. "Cdk5 acts as a mediator of neuronal cell cycle re-entry triggered by amyloid-ß and prion peptides". Cell Cycle 8 1 (2014): 97-104. https://publons.com/wos-op/publon/6041126/.
    10.4161/CC.8.1.7506
  39. Soares, E.; Prediger, R.D.; Nunes, S.; Castro, A.A.; Viana, S.D.; Lemos, C.; De Souza, C.M.; et al. "Spatial memory impairments in a prediabetic rat model". Neuroscience 250 (2013): 565-577. http://www.scopus.com/inward/record.url?eid=2-s2.0-84882959210&partnerID=MN8TOARS.
    10.1016/j.neuroscience.2013.07.055
  40. Garção, P.; Szabõ, E.C.; Wopereis, S.; Castro, A.A.; Tomé, A.R.; Prediger, R.D.; Cunha, R.A.; Agostinho, P.; Köfalvi, A.. "Functional interaction between pre-synaptic a6ß2-containing nicotinic and adenosine A2A receptors in the control of dopamine release in the rat striatum". British Journal of Pharmacology 169 7 (2013): 1600-1611. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880322083&partnerID=MN8TOARS.
    10.1111/bph.12234
  41. Silva, D.; Chioua, M.; Samadi, A.; Agostinho, P.; Garção, P.; Lajarín-Cuesta, R.; De Los Ríos, C.; et al. "Synthesis, pharmacological assessment, and molecular modeling of acetylcholinesterase/butyrylcholinesterase inhibitors: Effect against amyloid-ß-induced neurotoxicity". ACS Chemical Neuroscience 4 4 (2013): 547-565. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876529529&partnerID=MN8TOARS.
    10.1021/cn300178k
  42. Matos, M.; Augusto, E.; Agostinho, P.; Cunha, R.A.; Chen, J.-F.. "Antagonistic interaction between adenosine A 2A Receptors and Na + /K + -ATPase-a 2 controlling glutamate uptake in astrocytes". Journal of Neuroscience 33 47 (2013): 18492-18502. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887851711&partnerID=MN8TOARS.
    10.1523/JNEUROSCI.1828-13.2013
  43. Simões, A.P.; Duarte, J.A.; Agasse, F.; Canas, P.M.; Tomé, A.R.; Agostinho, P.; Cunha, R.A.. "Blockade of adenosine A 2A receptors prevents interleukin-1ß-induced exacerbation of neuronal toxicity through a p38 mitogen-activated protein kinase pathway". Journal of Neuroinflammation 9 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84865050131&partnerID=MN8TOARS.
    10.1186/1742-2094-9-204
  44. Matos, M.; Augusto, E.; MacHado, N.J.; Dos Santos-Rodrigues, A.; Cunha, R.A.; Agostinho, P.. "Astrocytic adenosine A2A receptors control the amyloid-ß peptide-induced decrease of glutamate uptake". Journal of Alzheimer's Disease 31 3 (2012): 555-567. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865592766&partnerID=MN8TOARS.
    10.3233/JAD-2012-120469
  45. Duarte, J.M.N.; Agostinho, P.M.; Carvalho, R.A.; Cunha, R.A.. "Caffeine consumption prevents diabetes-induced memory impairment and synaptotoxicity in the hippocampus of nonczno10/ltj mice". PLoS ONE 7 4 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84859733227&partnerID=MN8TOARS.
    10.1371/journal.pone.0021899
  46. Ferreira, S.G.; Teixeira, F.M.; Garção, P.; Agostinho, P.; Ledent, C.; Cortes, L.; MacKie, K.; Köfalvi, A.. "Presynaptic CB1 cannabinoid receptors control frontocortical serotonin and glutamate release - Species differences". Neurochemistry International 61 2 (2012): 219-226. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863463752&partnerID=MN8TOARS.
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  66. "The effect of amyloid-beta in the glutamate clearance by astrocytes". Neuron Glia Biology (2007): https://publons.com/wos-op/publon/6041107/.
  67. "Changes in nicotinic acetylcholine receptors under Alzheimer's disease conditions protection by galantamine". Journal of Neurochemistry (2007): https://publons.com/wos-op/publon/6041153/.
  68. Lopes, J. P.; Oliveira, C. R.; Agostinho, P.. "Role of cyclin-dependent kinase 5 in the neurodegenerative process of Alzheimer's disease and prion-related encephalopathies". Journal of Neurochemistry (2007): https://publons.com/wos-op/publon/6041152/.
  69. Garção, P.; Oliveira, C.R.; Agostinho, P.. "Comparative study of microglia activation induced by amyloid-beta and prion peptides: Role in neurodegeneration". Journal of Neuroscience Research 84 1 (2006): 182-193. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745782720&partnerID=MN8TOARS.
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  74. Pereira, C.; Agostinho, P.; Moreira, P.I.; Duarte, A.I.; Santos, M.S.; Oliveira, C.R.. "Neuroprotection strategies: Effect of vinpocetinein in vitro oxidative stress models,Estratégias de neuroprotecção: Efeito da vimpocetina em modelos in vitro de stresse oxidativo". Acta Medica Portuguesa 16 6 (2003): 401-406. http://www.scopus.com/inward/record.url?eid=2-s2.0-9644310235&partnerID=MN8TOARS.
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    10.3109/13506120209114097
  76. Agostinho, P.; Caseiro, P.; Rego, A.C.; Duarte, E.P.; Cunha, R.A.; Oliveira, C.R.. "Adenosine modulation of D-[3H]aspartate release in cultured retina cells exposed to oxidative stress". Neurochemistry International 36 3 (2000): 255-265. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033979263&partnerID=MN8TOARS.
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  77. Rego, A.C.; Agostinho, P.; Melo, J.; Cunha, R.A.; Oliveira, C.R.. "Adenosine A(2A) receptors regulate the extracellular accumulation of excitatory amino acids upon metabolic dysfunction in chick cultured retinal cells". Experimental Eye Research 70 5 (2000): 577-587. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033623815&partnerID=MN8TOARS.
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Capítulo de livro
  1. Canas, Paula M.; Cunha, Rodrigo A.; Agostinho, Paula. "Adenosine Receptors in Alzheimer’s Disease". In The Adenosine Receptors, editado por Borea P.; Gessi S; Merighi S; Vincenzi F., 259-280. Springer International Publishing, 2018.
    Publicado • 10.1007/978-3-319-90808-3_11
  2. Agostinho, Paula; João Pedro Lopes. "Agostinho P. Lopes JP. (2017) "Doenças de Priões ou encefalopatias espongiformes transmissíveis" Cap. 30 In Neurociências, Editora: Lidel- Portugal, pp 561.". In Neurociências, editado por Ana Cristina Rego; Catarina Resende Oliveira; Carlos Jorge Bandeira Duarte, 561. Portugal, 2017.
    Publicado
  3. Agostinho, Paula; Inês Pombinho de Araújo. "Ácido gama-aminobutírico" Cap. 30 In Neurociências, Editora: Lidel- Portugal, pp 103-123.". In Neurociências, editado por Ana Cristina Rego; Catarina R. Oliveira; Carlos Jorge Bandeira Duarte, 103-123. Portugal: LIDEL, 2017.
    Publicado
  4. Agostinho, Paula. "Neuroinflammation and mitochondrial dysfunction in Alzheimer´s and Prion´s diseases. In: "Interaction Between neurons and glia in aging and disease", Chapter 14, pp 309-332. Malva J.O., Rego A.C., Cunha R.A. Oliveira C.R. eds. Springer Publishers. New York, USA. ISBN:978-0-387-70829.". In Interaction Between Neurons and Glia in Aging and Disease. Springer US, 2007.
Livro
  1. Lopes, J.P.; Blurton-Jones, M.; Yamasaki, T.R.; Agostinho, P.; LaFerla, F.M.. Activation of cell cycle proteins in transgenic mice in response to neuronal loss but not aß and tau pathology. 2011.
    10.3233/978-1-60750-733-8-139
  2. Agostinho, P.; Oliveira, C.R.. Neuroinflammation and mitochondrial dysfunction in alzheimer's and prion's diseases. 2007.
    10.1007/978-0-387-70830-0_14
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2021/02/17 Adenosine A2A receptors modulate hemichannels activity in astrocytes treated with amyloid--ß peptides 51.ª Reunião da Sociedade Portuguesa de Farmacologia- Neuropharmacology I
Sociedade Portuguesa de Farmacologia (Lisboa (on-line), Portugal)
2021/02/17 Functional interaction beween ATP-P2X7 and adenosine A2A R receptors in the controlo of microglia Ca levels. 51.ª Reunião da Sociedade Portuguesa de Farmacologia
Sociedade Portuguesa de Farmacologia (Portugal)
2019/01/21 Impact of astrocytes and neuron-glia-communication on synaptic plasticity and memory” , 21 janeiro 2019 Neuroscience and Disease joint data-club
CiBB (Coimbra, Portugal)
2017 Astrocytic A2A Receptors: Novel Targets to Manage Brain Disorders 12th Young European Scientist (YES) Meeting, Porto, Portugal. Septembro,
(Porto, Portugal)
2015/12/04 Papel da astroglia na disfunção sináptica e nas alterações cognitivas. Foco na doença de Alzheimer V Congresso Luso-Brasileiro de Patologia Experimental & XV International Symposium on Experimental Techniques.
Sociedade Portuguess de Patologia Experimental (Coimbra, Portugal)
2012/11/16 Neuroinflammation VI Congresso do Núcleo de Estudantes de Farmácia- Imunologia, Doenças imunológicas e Imunoterapias
Associação Académica de Coimbra (NEF/AAC) (Coimbra, Portugal)
2009/11/15 Doença dos Priões e Neuroinflamação VII Jornadas Nacionais de Bioquímica
Universidade Beira Interior (Covilhã, Portugal)
2007/05/21 Microglial activation induced by amyloid and prion peptides: role in neurodegeneration 17th European Society for Neurochemistry Meeting-3rd Conference in Advances in Molecular Mechanisms of Neurological Disorders
European Society for Neurochemistry (Salamanca, Espanha)
2005/04 Os receptores nicotínicos e a Doença de Alzheimer Congresso Nacional da Associação Portuguesa de Gerontopsiquiatra
Associação Portuguesa de Gerontopsiquiatra (Albufeira, Portugal)
2004/05/06 Agentes infecciosos não convencionais XVII Jornadas de Engenharia Química
Instituto Superior Técnico (Lisboa, Portugal)
2003/06/12 Contribution of calcineurin and AKT/PKB to neurodegeneration induced by prion and beta-amyloid peptide 8th Meeting of the Portuguese Society for Neuroscience.
Sociedade Portuguesa de Neurociências (Curia, Portugal)
2002/12/05 Neurotoxic effects of amyloid-beta and prion peptides: the role of calcineurin XIII Congresso Nacional de Bioquímica. Lisboa, Portugal
Sociedade Portuguesa de Bioquímica (Lisboa, Portugal)
1997/11/10 Alterações na atividade dos transportadores dos neurotransmissores durante condições de stress oxidativo. Efeito de antioxidantes I Congresso de Investigação em Medicina
Universidade de Coimbra (Coimbra, Portugal)
1997/11 Effect of antioxidants on the dysfunction of excitatory amino acid transporters induced by oxidative stress in retinal cells Basic Mechanisms Related to Stress, Ischemia and Neuroprotection in Retina
Universidade de Coimbra (Coimbra, Portugal)
1995/05/23 Modulation of glutamate receptor activity under conditions of oxidative stress International Symposium on Cell Signalling
Universidade de Coimbra (Coimbra, Portugal)
1994/02/05 Potassium channels are involved in the control of neuronal excitability induced by oxidative stress First International Symposium on Neuroelectrochemistry
Universidade de Coimbra (Coimbra, Portugal)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2021/01/01 - Atual Role of adenosine A 2A receptors controlling synaptic senescence in ageing and Alzheimer´s disease
Coorientador
 Ciências Biomédicas (Doutoramento)
Universidade de Coimbra Faculdade de Medicina, Portugal
2019 - Atual Role of astrocytic adenosine A2A receptors in controlling aquaporin 4 under conditions of chronic stress. FCT grant SFRH/BD/147159/2019
Orientador
 Ciências Biomédicas (Doutoramento)
Universidade de Coimbra Faculdade de Medicina, Portugal
2018/11 - 2023/12/18 Astrocytic adenosine A2A receptor and connexin 43 crosstalk in Alzheimer´s disease FCT grant SFRH/BD/139334/2018,
Orientador de Daniela Isabel Ferreira Madeira
Ciências Biomédicas, (Doutoramento)
Universidade de Coimbra Faculdade de Medicina, Portugal
2020/01/01 - 2021/06/04 Astrocytes' morphological alterations with fear extinction – impact of A2A receptors blockade
Orientador
 Mestrado Integrado em Medicina (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2018/06/15 - 2019/07/19 Impact of astrocytes in memory: role of astrocytic adenosine A2A receptors
Orientador de Marlene Santos Domingues
 Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2017/07/01 - 2018/09/10 Effect of amyloid-beta peptides on astrocytic Ca2+ signaling and gliotransmission: modulation by adenosine A2A receptors
Orientador de Liliana Rodrigues Dias
Bioquímica (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2017/06/01 - 2018/09/07 Impact of an astrocytic pathology on hippocampal memory
Orientador de Catarina Isabel Moreira Leitão
Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2017/09/30 - 2018/09/05 Role of astrocytes in synaptic plasticity and memory in animal models of Alzheimer's disease
Orientador de Cátia Sofia Resende Lopes
Investigação Biomédica (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2016/07/01 - 2017/09/11 ATP and glutamate release by astrocytes under Alzheimer´s disease conditions: modulation by adenosine A2A receptors
Orientador de Daniela Isabel Ferreira Madeira
Investigação Biomédica (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2016/06/01 - 2017/07/19 Role of astrocytes in synaptic function and memory. Focus on adenosine A2A receptors
Orientador de Marlene Cristina Faria Pereira
Bioquímica (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2008 - 2014 Characterization of ecto-5´-nucleotidase (CD73) in the brain-role in adenosine A2A receptor activation
Coorientador
 Ciências Biomédicas (Doutoramento)
Universidade de Coimbra Faculdade de Medicina, Portugal
2012/06/01 - 2013/09/04 Interaction between ecto-5´- nucleotidase and adenosine A2A receptors in mice nerve terminals of mice prefrontal cortex
Orientador de Tiago Emanuel Soares Silva
Bioquímica (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2012/06/01 - 2013/07/02 Localization of secretases involved in the processing of ß-amyloid precursor protein related to Alzheimer´s disease
Orientador de Anna Vladímirovna Pliássova
Bioquímica (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2008 - 2013 Role of adenosine A2A receptors in astrocytes: implications for glutamatergic activity
Orientador de Marco António Paisana de Matos
Ciências Biomédicas (Doutoramento)
Universidade de Coimbra Faculdade de Medicina, Portugal
2005 - 2013 Functional interaction between presynaptic nicotinic and adenosine receptors in the control of dopamine release in the striatum
Orientador de Pedro Manuel Venâncio Garção
Ciências Biomédicas (Doutoramento)
Universidade de Coimbra Faculdade de Medicina, Portugal
2010 - 2011 Synaptic localization of amyloid precursor protein in the rat hippocampus
Orientador de Diana Isabel Queirós Guedes Rodrigues
Biologia Celular (Mestrado)
Universidade de Coimbra, Portugal
2004 - 2009 Neurodegeneration in Alzheimer´s disease and Prion-related encephalopathies: the role of cyclin-dependent kinase 5 and cell cycle regulators
Orientador de João Pedro Oliveira da Silva Paulino Lopes
 Biologia (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2006 - 2008 The effect of amyloid-beta peptide on the glutamate uptake by astrocytes
Orientador de Marco António Paisana de Matos
 Biologia Celular (Mestrado)
Universidade de Coimbra, Portugal
2000 - 2002 The effect of amyloid-beta peptide in cholinergic system. The role of oxidative stress and metabolic dysfunction
Coorientador de Maria Joana Barbosa de Melo
Biologia Celular
Universidade de Coimbra, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2021/11/30 - Atual V Symposium of Portuguese Glial Network Glial cells at the crossroad of health and disease (2021/10/07)
Encontro (Membro da Comissão Organizadora)
2001/05 - 2001/09 VII Annual Meeting of the Portuguese Society for Neuroscience”. Luso, Portugal (13-14 setembro) (2001/09/13 - 2001/09/14)
Congresso (Membro da Comissão Organizadora)
 Sociedade Portuguesa de Neurociências, Portugal

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2017/11 - Atual R A. Cunha, P Agostinho. “Adenosine A2A receptor over-activation is necessary and sufficient for the emergence of memory and synaptic plasticity deficits in animal models of early Alzheimer's disease” Poster: 208.09/G5 – Session Synaptic deficits in Alzheimer's disease and neurodegeneration I, 47Th Annual Meeting of the Society for Neuroscience. Washington DC- EUA, November 2017
Congresso
 47Th Annual Meeting of the Society for Neuroscience. Washington DC- EUA
Society for Neuroscience, Estados Unidos
2021/12/01 - 2021/12/03 Paula Agostinho, Cândida Dias, Rui A. Carvalho, Ana Ledo , João Laranjinha , Daniela Madeira, Liliana Dias , Rodrigo A. Cunha , Tibor Harkány , Attila Köfalvi , Astrocytic GPR55 Receptors Fuel Glycolysis, XVII meeting of the Portuguese Society for Neuroscience, Coimbra 1-3 december 2021
Congresso
 XVII meeting of the Portuguese Society for Neuroscience, Coimbra 1-3 december 2021
Sociedade Portuguesa de Neurociências, Portugal
2019/10/18 - 2019/10/23 P. M. Agostinho, M. Pereira, I. Amaral, C. Lopes, P. Canas, R. A. Cunha “Role of astrocytes on mouse hippocampal synaptic plasticity and memory. No. 205.08. 49Th Society for Neuroscience (SFN) meeting. Chicago, IL, USA; 18-23 October 2019
Congresso
 49Th Society for Neuroscience (SFN) meeting.
Society for Neuroscience, Estados Unidos
2019/07/10 - 2019/07/13 D. Madeira, L. Dias, A. Tomé, P. M. Canas, R. A. Cunha, P. Agostinho “Adenosine A2A receptors control amyloid-ß peptides-induced alteration of Ca2+ dynamics and ATP release in astrocytes” (Poster #726, T05-063B). XIV European meeting on glial cells in health and disease. (Abstract published in Wiley E-Only Supplement to Glia Journal). Porto, Portugal 10-13July 2019
Congresso
 XIV European meeting on glial cells in health and disease
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2019/07/10 - 2019/07/13 P. Agostinho, M. Perreira, I. Amaral, C. Leitão, C. Lopes, P. Canas, R. Cunha “Astrocytic dysfunction caused by L-a-aminoadipate impairs mouse hippocampal synaptic plasticity and memory (#644, T09-076B)” XIV European meeting on glial cells in health and disease. (Abstract published in Wiley E-Only Supplement to Glia Journal). Porto, Portugal 10-13July 2019
Congresso
 XIV European meeting on glial cells in health and disease.
2019/05/30 - 2019/06/01 Daniela Madeira, Liliana Dias; Patrícia Santos, Paula M. Canas, Rodrigo A. Cunha, Paula Agostinho “Alterations in connexin 43 triggered by amyloid-ß in astrocytes: modulation by adenosine A2A receptors” XVI Meeting of the Portuguese Society for Neuroscience". Lisboa, Portugal 30 May-June 1, 2019.
Congresso
 XVI Meeting of the Portuguese Society for Neuroscience
Sociedade Portuguesa de Neurociências, Portugal
2019/05/30 - 2019/06/01 Liliana Dias, Daniela Madeira, Ângelo R. Tomé, Rodrigo A. Cunha, Paula Agostinho “Amyloid-ß peptides affect astrocytic Ca2+ dynamics and exocytotic gliotransmitter release” XVI Meeting of the Portuguese Society for Neuroscience. Lisboa, Portugal 30 May-June 1, 2019
Congresso
 XVI Meeting of the Portuguese Society for Neuroscience.
Sociedade Portuguesa de Neurociências, Portugal
2019/05/30 - 2019/06/01 Cátia R. Lopes, Marlene Pereira, Inês Amaral, Paula M. Canas, Rodrigo A. Cunha, Paula Agostinho ”Astroglia control synaptic plasticity in an animal model of Alzheimer´s disease” XVI Meeting of the Portuguese Society for Neuroscience. Lisboa, Portugal 30 May-June 1, 2019.
Congresso
 XVI Meeting of the Portuguese Society for Neuroscience.
Sociedade Portuguesa de Neurociências, Portugal
2019/03/26 - 2019/03/30 Paula Agostinho, Cátia R. Lopes, Marlene Pereira, Inês Amaral, Paula M. Canas, Rodrigo A. Cunha “Impact of astrocytes on synaptic plasticity in Alzheimer’s disease condition” 14th International Conference on Alzheimer's and Parkinson's Diseases(AD/PD 2019) Lisbon, Portugal 26-31 March 2019.
Congresso
 14th International Conference on Alzheimer's and Parkinson's Diseases(AD/PD 2019)
2019/03/26 - 2019/03/30 Daniela Madeira, Liliana Dias, Ângelo R. Tomé, Paula M. Canas, Rodrigo A. Cunha, Paula Agostinho “Amyloid-ß peptides affect astrocytic gliotransmitter release and Ca 2+ dynamics. Protection by adenosine A 2A receptors blockade” 14th International Conference on Alzheimer's and Parkinson's Diseases(AD/PD 2019) Lisbon, Portugal 26-31 March 2019
Congresso
 14th International Conference on Alzheimer's and Parkinson's Diseases(AD/PD 2019)
2019/02/06 - 2019/02/08 Cátia Lopes, Marlene C. Pereira, Inês Amaral, Marlene Domingues, Paula M. Canas, Rodrigo A. Cunha, Paula Agostinho “Impact of astrocytes on synaptic plasticity in Alzheimer´s disease condition”.Session 1; XLIX Reunião Anual da Sociedade Portuguesa de Farmacologia. Porto, Portugal, 6-8 February 2019: ORAL
Congresso
 LIX Reunião Anual da Sociedade Portuguesa de Farmacologia.
Sociedade Portuguesa de Farmacologia, Portugal
2019/02/06 - 2019/02/08 Daniela Madeira, Liliana Dias, Patrícia Santos, Paula M. Canas, Rodrigo A. Cunha, Paula Agostinho “Impact of Amyloid -ß peptides on astrocytic gliotransmitters release: modulation by adenosine A2A receptors” Session 7; XLIX Reunião Anual da Sociedade Portuguesa de Farmacologia. Porto, Portugal, 6-8 February 2019: ORAL
Congresso
 XLIX Reunião Anual da Sociedade Portuguesa de Farmacologia
Sociedade Portuguesa de Farmacologia, Portugal
2019/02/06 - 2019/02/08 Liliana Dias, Daniela Madeira, Ângelo R. Tomé, Rodrigo A. Cunha, Paula AgostinhoInvolvement of adenosine A2A receptors in astrocytic Ca2+ dynamics in Alzheimer´s disease-like conditions. Session 7; XLIX Reunião Anual da Sociedade Portuguesa de Farmacologia. Porto, Portugal, 6-8 February 2019: ORAL
Congresso
 XLIX Reunião Anual da Sociedade Portuguesa de Farmacologia.
2018/07/07 - 2018/07/11 D.Madeira, L Dias, Â. R. Tomé, P.M. Canas, R. A. Cunha, P. Agostinho “Impact of amyloid-ß peptides on astrocytic gliotransmitter release and Ca2+ dynamics - modulation by adenosine A2A receptors” F18-3506, 11th FENS Forum of Neuroscience in Berlin, 7-11 July 2018
Congresso
 11th FENS Forum of Neuroscience in Berlin
Federation of European Neuroscience Societies, Bélgica
2018/07/07 - 2018/07/11 M.C. Pereira, I. Amaral, J.P. Lopes, C. Lopes, C. Leitão, R. A. Cunha, P. Agostinho “Pharmacological approaches to impinge astrocytic function: impact on mouse Hippocampal LTP” F18-3789 , 11th FENS Forum of Neuroscience in Berlin, 7-11 July 2018
Congresso
 11th FENS Forum of Neuroscience
Federation of European Neuroscience Societies, Bélgica
2018/07/07 - 2018/07/11 P.Santos, D.Madeira, , R. A. Cunha, P. Agostinho, P.M. Canas The role of astrocytic adenosine A2A receptors in depressive-like conditions F18-3382, FENS Forum of Neuroscience in Berlin, 7-11 July 2018
Congresso
 11Th FENS Forum of Neuroscience in Berlin
Federation of European Neuroscience Societies, Bélgica
2018/05/18 - 2018/05/18 C. Leitão, I. Amaral, M. Pereira, P.M. Canas, R.A. Cunha, P. Agostinho, “Astrocyte pathology is sufficient to trigger hippocampal synaptic dysfunction and memory loss in mice” III Symposium of Portuguese Glial Network, Porto, 18 maio 2018.
Simpósio
 III Symposium of Portuguese Glial Network
2018/05/18 - 2018/05/18 C. Lopes, M. Pereira, I. Amaral, P.M. Canas, R.A. Cunha, P. Agostinho, “Impact of astrocytes on synaptic dysfunction in a mice model of Alzheimer´s disease” III Symposium of Portuguese Glial Network, Porto, Maio 2018.
Simpósio
 III Symposium of Portuguese Glial Network,
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2018/05 - 2018/05 L. Dias, D. Madeira, P. Santos, P.M. Canas, R.A. Cunha, P. Agostinho, “Alterations in astrocytic gliotransmitter release triggered by amyloid-ß peptides - modulation by adenosine A2A receptors “III Symposium of Portuguese Glial Network, Porto, 18 Maio 2018.
Simpósio
 III Symposium of Portuguese Glial Network
2018/02 - 2018/02 D. Madeira, L. Dias, P. Santos, P. M. Canas, R. A. Cunha, P. Agostinho “5.1.- ATP and glutamate release by astrocytes under Alzheimer´s disease conditions: modulation by adenosine A2A receptors”. XLVIII Reunião Anual da Sociedade Portuguesa de Farmacologia. Lisboa, Portugal, Fevereiro 2018. ORAL
Congresso
 XLVIII Reunião Anual da Sociedade Portuguesa de Farmacologia.
2017/06/30 - 2017/07/01 D. Madeira, P. Santos, P.M. Canas, R.A. Cunha, P. Agostinho “ATP and glutamate release by astrocytes under Alzheimer´s disease conditions: Modulation by adenosine A2A receptors”. E-poster (apresentação oral de 5 minutos). 31ª Reunião do Grupo de estudos de envelhecimento e demência cerebral GEECD, Julho, 2017.
Congresso
 31ª Reunião do Grupo de estudos de envelhecimento e demência cerebral GEECD

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2022/09/20 "Mechanisms behind the pro-fibrotic role of adenosine in human subcutaneous fibroblasts and its contribution to myofascial pathological conditions"
Arguente principal
 Carine Talice Stübe Herman de Sousa (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2018/09/21 Relevance of astrocytes/microglia communication for NLRP3 signalling in the CNS - proof of concept in an ex vivo epilepsy model
Arguente principal
 Catarina Isabel Carvalhas (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016/01 PhD. thesis “Purines control Neuron-Glia interaction during Neuroinflammation”
Arguente
 Jimmy George. (Doutoramento)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2015/12/11 Modulatory effects of the chemokine fractalkine in a model of endotoxin-induced microglial activation
Arguente
 Ismael Araújo Neiva (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2015 Pathophysiology of hippocampalCA3 neurons in the APP/PSI Mouse Model of Alzheimer's Disease
Arguente
 Sílvia Margarida Viana da Silva (Doutoramento)
Universidade de Coimbra Faculdade de Medicina, Portugal
2013/09/06 Modulation of pro-inflammatory response of retina by adenosinergic systems. Neuroinflammation/neuroprotection
Arguente principal
 Raquel Sofia Freitas Boia (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013 Validation of tau aggregation model in HEK cells and cortical rat neurons
Arguente
 Rita Marisa Gomes Marreiros (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2012 Purinergic control of neuroinflammation and neuroprotection by the blockade of P2 receptors under excitotoxicity condition in the hippocampus
Arguente
 Ana Patrícia Figueiredo Rocha Simões (Doutoramento)
Universidade de Coimbra Faculdade de Medicina, Portugal
2012 Presynaptic A2A adenosine receptors control CB1 cannabinoid receptor-mediated effects at corticostriatal nerve terminals
Arguente
 Samira Cardoso Lopes Ferreira (Doutoramento)
Universidade de Coimbra Faculdade de Medicina, Portugal
2012 Purinergic control of neuroinflammation and neuroprotection by the blockade of P2 receptors under excitotoxicity condition in the hippocampus Ana Patrícia Figueiredo da Rocha Simões (Doutoramento)
Universidade de Coimbra Faculdade de Medicina, Portugal
2011 Modulação purinérgica do transporte de GABA e glutamato na epilepsia
Arguente
 Aurora Raquel Barros Barbosa (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2010 Sprague Dawley rat as non-transgenic animal model for testing of new amyloid-lowering therapies
Arguente
 Remy Cardoso (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009 Neuroprotection by adenosine A2A receptors in aged rats – role of neuroinflammation
Arguente
 Paula Margarida Gomes Canas (Doutoramento)
Universidade de Coimbra Faculdade de Medicina, Portugal
2008 Crosstalk between endoplasmic reticulum and mitochondria in the neurotoxicity induced by amyloid-beta and prion peptides
Arguente
 Elisabete Baptista Ferreiro (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Arbitragem científica em conferência

Nome da conferência Local da conferência
2019 - Atual 49.ª Reunião da Sociedade Portuguesa de Farmacologia Porto
2013 - Atual XXVII Reunião do Grupo de Estudos sobre Envelhecimento Cerebral e Demência Coimbra
2007 - Atual XXI Reunião do Grupo de Estudos sobre Envelhecimento Cerebral e Demência Luso
2021/02/17 - 2021/02/19 51.ª Reunião da Sociedade Portuguesa de Farmacologia, Lisboa

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2011 - Atual Aging Cell (1474-9726) Wiley Online Library
2009 - Atual Neurobiology of Disease (0969-9961) Elsevier
2019/09/01 - 2022/01/30 Frontiers of Neuroscience- Special issue Adenosinergic System and Central Nervous System Disorders (1662-453X ) Frontiers

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2022 - Atual Master course of Neurophysiology and Cognition (Mestrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2017/09 - Atual Aulas Práticas Bioquímica I Mestrado integrado medicina (Mestrado integrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2012/09/15 - Atual Biologia Celular do Desenvolvimento Humano. Engenharia Biomédica (Mestrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2010 - Atual Tecnologias de Investigação em Neurobiologia Engenharia Biomédica (Mestrado) Universidade de Coimbra Faculdade de Medicina, Portugal

Entrevista (jornal / revista)

Descrição da atividade Jornal / Forum
2014/05 Reportagem no âmbito do “Investigador do Mês” para a Revista Prevenir, nº 104 Revista Prevenir

Entrevista / Programa (rádio / tv)

Programa Tema
2014/05 - Atual Mentes que Brilham Doença de Alzheimer -terapêuticas

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2019/03/01 - 2021/12 Guest Editor of a special issue of Frontiers of Neuroscience "Adenosinergic System and Central Nervous System Disorders
Outro

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2012 - Atual Evaluation of research projects- Czech Science Foundation” (República Checa)

Tutoria

Tópico Nome do aluno
2015 - 2018 Post-Doctoral research investigator (co-tutor) João Pedro Oliveira da Silva Paulino Lopes
2011/08 - 2012/09 Co-tutor PhD degree Stefania Zappettini
Distinções

Outra distinção

2005 Short-term grants
Fundação Calouste Gulbenkian, Portugal
2003 Short-term grants
Fundação Calouste Gulbenkian, Portugal
2000 Short-term grants
Fundação Calouste Gulbenkian, Portugal