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João Franco Machado is a Resident Pharmacist of Clinical Chemistry at Western Lisbon Hospital Centre since January 2024. He has an Integrated Master's degree in Pharmaceutical Sciences (PharmD) by the Faculty of Pharmacy, University of Lisbon (2016) and a PhD degree in Chemistry by the Faculty of Sciences, University of Lisbon (2024). _________________________________________________________________________________________________________________________________ João started his research path as an undergraduate student at the Research Institute for Medicines (Portugal) in 2012. After graduating in 2016, he moved to the Swiss Federal Institute of Technology in Lausanne (Switzerland) to work as a Researcher and Teaching Assistant (2016-2017). João was named "Highly Commended in Chemical & Pharmaceutical Sciences" by The Global Undergraduate Awards (Dublin) under the patronage of His Excellency the President of Ireland in 2017. Afterwards, he moved back to Portugal to purse a PhD in Bioinorganic Chemistry, jointly at the Centre for Structural Chemistry and at the Centre for Nuclear Sciences and Technologies (2018-2024). Currently, João develops his research activities at the Clinical Pathology Department of São Francisco Xavier's University Hospital. _________________________________________________________________________________________________________________________________ João's major scientific activity focuses on Clinical and Medicinal Inorganic Chemistry. He is currently interested in developing novel metallodrugs for diagnosis and precision therapy of renal, cardiac, and malignant diseases. He has published a total of 12 articles, 1 international patent, 1 book chapter, 8 proceedings, 6 other publications, 14 oral communications, and 29 poster communications (h-index: 9).
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Identificação

Identificação pessoal

Nome completo
João Miguel Franco Machado
Data de nascimento
1993/07/10
Género
Masculino

Nomes de citação

  • João Franco Machado
  • João F. Machado
  • J. Franco Machado

Identificadores de autor

Ciência ID
CE14-F7CF-936B
ORCID iD
0000-0003-3741-2386
Google Scholar ID
Tt6gKOEAAAAJ&hl
Researcher Id
M-1891-2015
Scopus Author Id
57205179269

Endereços de correio eletrónico

  • joaomachado@edu.ulisboa.pt (Profissional)
  • jmmachado@ulslo.min-saude.pt (Profissional)

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Química Médica
  • Ciências Exatas - Química - Química Inorgânica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Espanhol; Castelhano Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Francês Utilizador elementar (A2) Utilizador elementar (A2) Utilizador elementar (A2) Utilizador elementar (A2) Utilizador elementar (A2)
Formação
Grau Classificação
2024/01 - 2028/01
Em curso
 Análises Clínicas (Título de especialista)
Especialização em Clinical Chemistry and Laboratory Medicine
Administração Central do Sistema de Saúde IP, Portugal
2024/09 - 2024/12
Em curso
 Post-graduate course in Biostatistics in Clinical Research (30h) (Pós-Graduação)
University of Cape Town, África do Sul
2018/10 - 2024/04
Concluído
 Química (Doutoramento)
Especialização em Inorganic Chemistry
Universidade de Lisboa Faculdade de Ciências, Portugal
"Novel ruthenium-peptide conjugates for precision therapy of metastatic breast cancer" (TESE/DISSERTAÇÃO)
 Approved Summa cum Laude
2023/07 - 2023/09
Concluído
 Post-graduate course in Hospital Pharmacy and Clinical Analysis (64h) (Pós-Graduação)
Ordem dos Farmacêuticos, Portugal
 Approved
2018/10 - 2018/10
Concluído
 Post-graduate course in Modern Methods of Chemical Structure Elucidation (35h) (Pós-Graduação)
Universidade de Lisboa Instituto Superior Técnico, Portugal
 Approved
2017/03 - 2017/07
Concluído
 Post-graduate course in Current Topics in Chemical Biology (60h) (Pós-Graduação)
École polytechnique fédérale de Lausanne Faculté des sciences de base, Suiça
 Approved
2016/10 - 2017/02
Concluído
 Post-graduate course in Principles of Drug Action at Cardiovascular and Nervous Systems (60h) (Pós-Graduação)
École polytechnique fédérale de Lausanne Faculté des sciences de base, Suiça
 Approved
2016/09 - 2016/09
Concluído
 Post-graduate course in Pharmacy Practice (40h) (Pós-Graduação)
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Approved
2011/09 - 2016/09
Concluído
 Ciências Farmacêuticas (Mestrado integrado)
Especialização em Pharmacy, Chemistry, Biology
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Development of a novel macrocyclic compound with in vitro antifungal activity" (TESE/DISSERTAÇÃO)
 ESCC: grade A (16/20)
Percurso profissional

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2024/01/01 - Atual Resident Pharmacist Centro Hospitalar de Lisboa Ocidental EPE, Portugal
Serviço de Patologia Clínica, Hospital de São Francisco Xavier, Portugal
2018/10/01 - 2024/04/30 PhD Student Universidade de Lisboa Faculdade de Ciências, Portugal
Universidade de Lisboa Centro de Química Estrutural and Centro de Ciências e Tecnologias Nucleares, Portugal
2016/10/01 - 2017/12/01 Researcher and Teaching Assistant École Polytechnique Fédérale de Lausanne, Suiça
École Polytechnique Fédérale de Lausanne Institut des sciences et ingénierie chimiques, Suiça
2011/09/01 - 2016/09/01 Undergraduate Student (volunteer) Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Projetos

Bolsa

Designação Financiadores
2021/03/01 - 2024/11/01 Ruthenium-peptide conjugates: arrows for selectively targeting breast cancer
PTDC/QUI-QIN/0146/2020
Investigador
Fundação para a Ciência e a Tecnologia
Concluído
2018/10/01 - 2022/12/01 Targeting metastatic breast cancer with innovative ruthenium-peptide conjugates
SFRH/BD/135915/2018
Bolseiro de Doutoramento
Fundação para a Ciência e a Tecnologia
Em curso
2016/10/01 - 2017/12/01 Novel bioconjugation strategy and application for drug development
157842
Investigador
Swiss National Science Foundation Consolidator Grant
Produções

Publicações

Artigo em conferência
  1. Marques, B.; João Franco Machado; Silva, M.T.; Marques, F.; Garcia, M.H.; Coelho, J.A.S.; Morais, T.S.. "New ruthenium antibiotic conjugates for synergistic anticancer/antibiotic activity (Proceeding; ISBN: 978-989-33-4904-5)". Trabalho apresentado em 3rd Chem&Biochem Students Meeting, Lisbon, 2023.
  2. João Franco Machado; Silva, M.T.; Pires, I.; Marques, F.; Machuqueiro, M.; Garcia, M.H.; Correia, J.D.G.; Morais, T.S.. "Innovative smart metallodrug delivery systems for targeted therapy of metastatic breast cancer (Proceeding; ISBN: 978-989-33-4904-5)". Trabalho apresentado em 3rd Chem&Biochem Students Meeting, Lisbon, 2023.
  3. Sá, M.; João Franco Machado; Garcia, M.H.; Morais, T.S.. "Synthesis and structural characterization of new Ru-cyclopentadienyl complexes for potential application in triple-negative breast cancer therapy (Proceeding; ISBN: 978-989-33-3550-5)". Trabalho apresentado em 2nd Chem&Biochem Students Meeting, Lisbon, 2022.
  4. João Franco Machado; Silva, M.T.; Marques, F.; Machuqueiro, M.; Garcia, M.H.; Coelho, J.A.S.; Correia, J.D.G.; Morais, T.S.. "Novel pH-responsive ruthenium-peptide conjugates for the precision therapy of metastatic breast cancer (Proceeding; ISBN: 978-989-33-3550-5)". Trabalho apresentado em 2nd Chem & Biochem Students Meeting, Lisbon, 2022.
  5. João Franco Machado; Machuqueiro, M.; Marques, F.; Garcia, M.H.; Correia, J.D.G.; Morais, T.S.. "Targeting FGFR(+) breast cancer cells with half-sandwich ruthenium(II)-cyclopentadienyl peptide conjugates (Proceeding; ISBN: 978-989-8124-31-9)". Trabalho apresentado em 7th Portuguese Young Chemists Meeting, Lisbon, 2021.
  6. João Franco Machado; Marques, F.; Piedade, M.F.M.; Villa Brito, M.J.; Garcia, M.H.; Morais, T.S.. "Copper(I)-phosphane complexes as promising anticancer agents (Proceeding; ISBN: 978-989-8124-24-1)". Trabalho apresentado em XXIV Encontro Luso-Galego de Química, Porto, 2018.
  7. João Franco Machado; Pontes, A.; Castro, M.; Costa, J.; Martins, M.L.; Cabral, M.F.. "Synthesis, potentiometric and antifungal studies of two thia-tetraaza macrocyclic ligands and their Cu(II) and Ni(II) complexes (Proceeding; ISBN: 978-84-608-3441-0)". Trabalho apresentado em XXI Encontro Galego-Portugués de Química, Pontevedra, 2015.
  8. Cabral, M.F.; Torres, N.; Costa, J.; Fernandes, A.S.; Gonçalves, S.; João F. Machado; Villa Brito, M.J.; Martins, M.L.; Castro, M.. "Thia-tetraaza macrocyclic compounds as potential agents for treatment of fungal infections (Proceeding; ISBN: 978-84-695-8688-4)". Trabalho apresentado em XIX Encontro Galego-Portugués de Química, Vigo, 2013.
Artigo em revista
  1. João Franco Machado; Cordeiro, S; Duarte, J.N.; Costa, P.J.; Mendes, P.J.; Garcia, M.H.; Baptista, P.V.; Fernandes, A.R.; Morais, T.S.. "Exploiting Co(III)-Cyclopentadienyl Complexes To Develop Anticancer Agents". Inorganic Chemistry 63 (2024): 5783-5804. http://dx.doi.org/10.1021/acs.inorgchem.3c03696.
    10.1021/acs.inorgchem.3c03696
  2. João Franco Machado; Sá, M.; Pires, I.; Silva, M.; Marques, F.; Celho, J.A.S.; Mendes, F.; Piedade, M.F.M.;; Machuqueiro, M.; Jiménez, M.A.; Garcia, M.H.; Correia, J.D.G.; Morais, T.S.. "Dual FGFR-targeting and pH-activable Ruthenium-Peptide Conjugates for targeted therapy of Breast Cancer (Selected as Front Cover)". Dalton Transactions 53 (2024): 7682-7693. http://dx.doi.org/10.1039/d4dt00497c.
    10.1039/d4dt00497c
  3. João Franco Machado; Marques, F.; Pinheiro, T.; Villa de Brito, M.J.; Scalese, G.; Perez-Dias, L.O.; António, J.P.M.; Gambino, D. "Copper(I)-Thiosemicarbazone Complexes with Dual Anticancer and Antiparasitic Activity (Selected as Very Important Paper; Reported by press)". ChemMedChem 18 (2023): 1-10. http://dx.doi.org/10.1002/cmdc.202300074.
    10.1002/cmdc.202300074
  4. João Franco Machado; Morais, T.S.. "Are smart delivery systems the solution to overcome the lack of selectivity of current metallodrugs in cancer therapy? (Invited Article; Selected as Front Cover; Selected as Hot Topic)". Dalton Transactions 51 (2022): 2593-2609. http://dx.doi.org/10.1039/d1dt04079k.
    10.1039/d1dt04079k
  5. Silva, R.D.M.; João Franco Machado; Gonçalves, K.; Lucas, F.M.; Batista, S.; Melo, R.; Morais, T.S.; Correia, J.D.G.. "Ultrasonication Improves Solid Phase Synthesis of Peptides Specific for Fibroblast Growth Factor Receptor and for the Protein-Protein Interface RANK-TRAF6". Molecules 26 (2021): 7349-7358. http://dx.doi.org/10.3390/molecules26237349.
    10.3390/molecules26237349
  6. Schlagintweit, J.F.; Jakob, C.H.G.; Wilke, N.L.; Ahrweiler, M.; Frias, C.; Frias, J.; König, M.; Esslinger, E.M.H.J.; Marques, F.M.; João Franco Machado; Reich, R.M.; Morais, T.S.; Correia, J.D.G.; Prokop, A.; Kühn, F.E.. "Gold(I) Bis(1,2,3-triazol-5-ylidene) Complexes as Promising Selective Anticancer Compounds". Journal of Medicinal Chemistry 64 (2021): 15747-15757. http://dx.doi.org/10.1021/acs.jmedchem.1c01021.
    10.1021/acs.jmedchem.1c01021
  7. João Franco Machado; Correia, João D. G.; Morais, Tânia S.. "Emerging Molecular Receptors for the Specific-Target Delivery of Ruthenium and Gold Complexes into Cancer Cells". Molecules 26 (2021): 3153-3191. http://dx.doi.org/10.3390/molecules26113153.
    10.3390/molecules26113153
  8. João Franco Machado; Machuqueiro, Miguel; Marques, Fernanda M.; Robalo, Maria Paula Alves; Minas da Piedade, Maria Fátima; Garcia, Maria Helena; Correia, João D. G.; Morais, Tânia S.. "Novel ''ruthenium cyclopentadienyl''-peptide conjugate complexes against human FGFR(+) breast cancer". Dalton Transactions 49 (2020): 5974-5987. http://dx.doi.org/10.1039/d0dt00955e.
    10.1039/d0dt00955e
  9. João Franco Machado; Sequeira, Diogo; Marques, Fernanda; Piedade, M. Fátima M.; Villa de Brito, Maria J.; Helena Garcia, M.; Fernandes, Alexandra R.; Morais, Tânia S.. "New copper(I) complexes selective for prostate cancer cells (Selected as Hot Topic)". Dalton Transactions 49 (2020): 12273-12286. http://dx.doi.org/10.1039/d0dt02157a.
    10.1039/d0dt02157a
  10. Kale, S. S.; Bergeron-Brlek, M.; Wu, Y.; Kumar, M. G.; Pham, M. V.; Bortoli, J.; Vesin, J.; Kong, X.-D.; João Franco Machado; Deyle, K.; Gonschorek, P.; Turcatti, G.; Cendron, L.; Angelini, A.; Heinis, C.. "Thiol-to-amine cyclization reaction enables screening of large libraries of macrocyclic compounds and the generation of sub-kilodalton ligands (Reported by press)". Science Advances 5 (2019): 1-9. http://dx.doi.org/10.1126/sciadv.aaw2851.
    10.1126/sciadv.aaw2851
  11. João Franco Machado; Silva, R.D.; Melo, R.; Correia, J.D.G.. "Less Exploited GPCRs in Precision Medicine: Targets for Molecular Imaging and Theranostics". Molecules 24 (2018): 49-77. https://doi.org/10.3390/molecules24010049.
    10.3390/molecules24010049
  12. Torres, N.; Gonçalves, S.; Fernandes, A.S.; João Franco Machado; Villa Brito, M.J.; Oliveira, N.G.; Castro, M.; Costa, J.; Cabral, M.F.. "[15]aneN4S: Synthesis, Thermodynamic Studies and Potential Applications in Chelation Therapy". Molecules 19 (2014): 550-567. https://doi.org/10.3390/molecules19010550.
    10.3390/molecules19010550
Capítulo de livro
  1. Costa, J.; João Franco Machado; Cabral, M.F.. "Preparation of a thia-tetraaza macrocyclic compound through a dual-step synthesis". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom (ISBN: 978-1-84973-963-4), 798-802. Reino Unido: Royal Society of Chemistry, 2017.
Edição de livro
  1. Fortuna, A.; Feliciano, I.; João Franco Machado; Silva, T.; Morgado, V. Book of abstracts of the 2nd Chem&Biochem Students Meeting (ISBN: 978-989-33-3550-5). Lisbon, Portugal: Organizing Committee of the 2nd Chem & Biochem Students Meeting; 1st edition. 2022.
    Editor
Entrada de enciclopédia
  1. João Franco Machado; Correia, J.D.G.; Morais, T.S.. "Cell Adhesion Molecules (CAM)". In Scholarly Community Encyclopedia, 2021. https://encyclopedia.pub/entry/10530.
Poster em conferência
  1. João Franco Machado; Silva, C.; Loaiza, M.; Gamelas, C.; Azevedo, A.P.. "Spurious leukopenia due to ex vivo cold-induced agglutination of polymorphonuclear neutrophils (Poster Communication; Corresponding author: João Franco Machado)". Trabalho apresentado em IX National Meeting of Clinical Pathology Residents, 2024.
  2. João Franco Machado; Fonseca, I.; Soares, J.; Cardoso, C.; Figueira, J.M; Azevedo, A.P.. "Assessment of laboratory turnaround time of high-sensitivity cardiac Troponin T testing from the emergency department of a Lisbon hospital (Poster Communication; Corresponding author: João Franco Machado)". Trabalho apresentado em 16th Scientific Meeting of the Portuguese Laboratory Medicine Society, 2024.
  3. Marques, B.; João Franco Machado; Silva, M.T.; Marques, F.; Garcia, M.H.; Coelho, J.A.S.; Morais, T.S.. "New ruthenium antibiotic conjugates for synergistic anticancer/antibiotic activity (Poster Communication; ISBN: 978-989-33-4904-5)". Trabalho apresentado em 3rd Chem&Biochem Students Meeting, 2023.
  4. Sá, M.; João Franco Machado; Garcia, M.H.; Morais, T.S.. "Synthesis and structural characterization of new Ru-cyclopentadienyl complexes for potential application in triple-negative breast cancer therapy (Poster Communication; ISBN: 978-989-33-3550-5)". Trabalho apresentado em 2nd Chem&Biochem Students Meeting, 2022.
  5. João Franco Machado; Silva, M.T.; Marques, F.; Machuqueiro, M.; Garcia, M.H.; Coelho, J.A.S.; Correia, J.D.G.; Morais, T.S.. "Novel pH-responsive ruthenium-peptide conjugates for the precision therapy of metastatic breast cancer (Poster Communication; ISBN: 978-989-33-3550-5)". Trabalho apresentado em 2nd Chem&Biochem Students Meeting, 2022.
  6. Marques, B.; João Franco Machado; Silva, M.T.; Marques, F.; Coelho, J.A.S.; Garcia, M.H.; Morais, T.S.. "New ruthenium-antibiotic conjugates as potential bifunctional anticancer agents (Poster Communication)". Trabalho apresentado em 4th CQE Days Spring Meeting, 2022.
  7. Duarte, J.N.; João Franco Machado; Cordeiro, S.; Baptista, P.V.; Garcia, M.H.; Fernandes, A.R.; Morais, T.S.. "New Co(III)(eta5-C5H5) organometallic complexes for potential application in cancer therapy (Poster Communication)". Trabalho apresentado em 4th CQE Days Spring Meeting, 2022.
  8. Mateus, M.; João Franco Machado; Silva, M.T.; Marques, F.; Garcia, M.H.; Morais, T.S.; Coelho, J.A.S.. "Development of a monosubstituted 2,2’-bipyridine ligand for a new promising anticancer ruthenium complex (Poster Communication)". Trabalho apresentado em 4th CQE Days Spring Meeting, 2022.
  9. Morais, T.S; João Franco Machado; Sá, M.; Machuqueiro, M.; Marques, F.; Garcia, M.H.; Correia, J.D.G.. "Targeted delivery of Ru-cyclopentadienyl complexes to breast cancer cells with FGFR-specific peptides (Poster Communication)". Trabalho apresentado em 8th Latin American Symposium on Coordination and Organometallic Chemistry, 2022.
  10. Villa Brito, M.J.; Morais, T.S.; João Franco Machado. "Copper(I) complexes with anticancer activity (Poster Communication)". Trabalho apresentado em 8th Latin American Symposium on Coordination and Organometallic Chemistry, 2022.
  11. João Franco Machado; Cordeiro, S.; Duarte, J.N.; Lourenço, M.J.; Baptista, P.V.; Garcia, M.H.; Fernandes, A.R.; Morais, T.S.. "New cobalt-cyclopentadienyl complexes with promising in vitro antiproliferative activity (Poster Communication)". Trabalho apresentado em 8th Latin American Symposium on Coordination and Organometallic Chemistry, 2022.
  12. Robalo, M.P.; João Franco Machado; Mendes, P.J.; Morais, T.S.; Garcia, M.H.. "Electrochemical behaviour of 1,10-phenanthroline based [CpRu(PPh3)(L_L)]+ complexes (Poster Communication)". Trabalho apresentado em XXIV Meeting of the Portuguese Electrochemical Society, 2021.
  13. Morais, T.S.; João Franco Machado; Machuqueiro, M.; Marques, F.; Garcia, M.H.; Correia, J.D.G.. "Targeting metastatic breast cancer with half-sandwich ruthenium(II)-cyclopentadienyl peptide conjugates (Poster Communication)". Trabalho apresentado em 56th International Conference on Medicinal Chemistry, 2021.
  14. João Franco Machado; Machuqueiro, M.; Marques, F.; Garcia, M.H.; Correia, J.D.G.; Morais, T.S.. "New ruthenium-peptide conjugates for selective targeting of breast cancer (Poster Communication)". Trabalho apresentado em 3rd CQE Days Spring Meeting, 2021.
  15. João Franco Machado; Machuqueiro, M.; Marques, F.; Garcia, M.H.; Correia, J.D.G.; Morais, T.S.. "Targeting FGFR(+) breast cancer cells with half-sandwich ruthenium(II)-cyclopentadienyl peptide conjugates (Poster Communication; ISBN: 978-989-8124-31-9)". Trabalho apresentado em 7th Portuguese Young Chemists Meeting, 2021.
  16. João Franco Machado; Machuqueiro, M.; Marques, F.; Robalo, M.P.; Piedade, M.F.M.; Garcia, M.H.; Correia, J.D.G.; Morais, T.S.. "Ru-peptide conjugates for targeting metastatic breast cancer (Poster Communication)". Trabalho apresentado em 2nd CQE Days Spring Meeting, 2020.
  17. João Franco Machado; Marques, F.; Piedade, M.F.M.; Villa Brito, M.J.; Garcia, M.H.; Morais, T.S.. "New selective Copper(I) complexes for prostate cancer cells (Poster Communication)". Trabalho apresentado em Ciências Research Day 2019, 2019.
  18. Pereira, J.; João Franco Machado; Costa, J.; Villa Brito, M.J.; Castro, M.; Lopes, M.M.; Cabral, M.F.. "Cu(II) and Ni(II) complexes of two novel thia-dioxo-triaza macrocycles with promising in vitro activity against Candida genus (Poster Communication)". Trabalho apresentado em 4th Meeting of the College of Chemistry of ULisboa, 2019.
  19. João Franco Machado; Pereira, M.P.; Robalo, P.; Piedade, M.F.M.; Garcia, M.H.; Morais, T.S.. "New ruthenium(II)-cyclopentadienyl complexes for cancer therapy: synthesis, characterisation and interaction with human serum albumin (Poster Communication)". Trabalho apresentado em 4th Meeting of the College of Chemistry of ULisboa, 2019.
  20. João Franco Machado; Marques, F.; Piedade, M.F.M.; Villa Brito, M.J.; Garcia, M.H.; Morais, T.S.. "New selective Copper(I) complexes for prostate cancer cells (Poster Communication)". Trabalho apresentado em 1st CQE Days Spring Meeting, 2019.
  21. Pereira, M.P.; João Franco Machado; Piedade, M.F.M.; Garcia, M.H.; Morais, T.S.. "Synthesis and characterization of a new family of ruthenium(II) complexes with phenantroline derivated ligands for anticancer applications (Poster Communication)". Trabalho apresentado em 1st CQE Days Spring Meeting, 2019.
  22. Morais, T.S.; Bravo, C.; João Franco Machado; Xavier, N.; Villa Brito, M.J.; Garcia, M.H.. "Synthesis and characterization of new copper(I) complexes comprising carbohydrates for cancer therapy (Poster Communication)". Trabalho apresentado em 29th International Carbohydrate Symposium, 2018.
  23. João Franco Machado; Ribeiro, D.I.; Villa Brito, M.J.; Piedade, M.F.M; Garcia, M.H.; Morais, T.S.. "Synthesis and structural characterisation of a new family of copper(I)-phosphane complexes for cancer therapy (Poster Communication)". Trabalho apresentado em rd Meeting of the College of Chemistry of ULisboa, 2018.
  24. João Franco Machado; Costa, J.; Castro, M.; Lopes, M.M.; Cabral, M.F.. "Thia-polyaza macrocyclic antifungal agents: synthesis and thermodynamic studies (Poster Communication)". Trabalho apresentado em 8th iMed.ULisboa Postgraduate Students Meeting & 1st i3DU Meeting, 2016.
  25. João Franco Machado; Pontes, A.; Villa Brito, M.J.; Castro, M.; Costa, J.; Martins, M.L.; Cabral, M.F.. "Dioxo-thia-triaza macrocyclic compounds as potential therapeutic agents for Candida infections (Poster Communication)". Trabalho apresentado em 5th Portuguese Young Chemists Meeting, 1st European Young Chemists Meeting, 2016.
  26. João Franco Machado; Torres, N.; Padilla, J.; Villa Brito, M.J.; Costa, J.; Castro, M; Cabral, M.F.. "Acid-base and thermodynamic studies with dioxo-thia macrocyclic compounds (Poster Communication)". Trabalho apresentado em 1st EFMC Young Medicinal Chemist Symposium, 2014.
  27. João Franco Machado; Torres, N.; Fernandes, A.S.; Martins, M.L.; Costa, J.; Castro, M; Cabral, M.F.. "Chemical and biological studies with macrocyclic compounds containing sulphur and nitrogen as donor atoms (Poster Communication)". Trabalho apresentado em 6th iMed.ULisboa Postgraduate Students Meeting, 2014.
  28. Cabral, M.F.; Torres, N.; Costa, J.; Fernandes, A.S.; Gonçalves, S.; João Franco Machado; Villa Brito, M.J.; Martins, M.L.; Castro, M.. "Thia-tetraaza macrocyclic compounds as potential agents for treatment of fungal infections (Poster Communication; ISBN: 978-84-695-8688-4)". Trabalho apresentado em XIX Encontro Galego-Portugués de Química, 2013.
  29. Cabral, M.F.; Costa, J.; João Franco Machado; Gonçalves S.; Padilla, J.; Villa Brito, M.J.; Torres, N.. "Synthesis and structural characterization of two dioxo-thia-triaza macrocyclic compounds (Poster Communication)". Trabalho apresentado em 10º Encontro Nacional de Química Orgânica, 1º Simpósio Luso-Brasileiro de Química Orgânica, 2013.
Recurso online
  1. João Franco Machado. Dioxo-[14]aneN3S: A novel macrocyclic compound with antifungal activity against Candida genus. 2017. https://gua.soutron.net/Portal/Default/en-GB/RecordView/Index/1255/.
  2. João Franco Machado; Costa, J.; Cabral, M.F.. Synthesis of a novel 14-membered oxo-thia-aza macrocyclic compound. 2015. https://www.epsa-online.org/epsa-students-science-publication/.
Resumo em conferência
  1. João Franco Machado; Silva, M.T.; Pires, I.; Marques, F.; Machuqueiro, M.; Garcia, M.H.; Correia, J.D.G.; Morais, T.S.. "Innovative smart metallodrug delivery systems for targeted therapy of metastatic breast cancer (Oral Communication; ISBN: 978-989-33-4904-5)". Trabalho apresentado em 3rd Chem&Biochem Students Meeting, Lisbon, 2023.
  2. Morais, T.S; João Franco Machado; Silva, M.T.; Marques, F.; Mendes, F.B.; Garcia, M.H.; Correia, J.D.G.. "Tumoral microenvironment-responsive ruthenium-peptide conjugates for precision therapy of breast cancer (Oral Communication)". Trabalho apresentado em XII Bioinorganic Meeting, Madrid, 2022.
  3. João Franco Machado; Duarte, J.N.; Silva, M.T.; Marques, F.; Mendes, F.B.;; Garcia, M.H.; Correia, J.D.G.; Morais, T.S.. "Hunting metastatic breast cancer with novel ruthenium smart metallodrug delivery systems (Oral Communication; Selected as Best Oral Communication)". Trabalho apresentado em 4th CQE Days Spring Meeting, Lisbon, 2022.
  4. João Franco Machado; Machuqueiro, M.; Marques, F.; Garcia, M.H.; Correia, J.D.G.; Morais, T.S.. "Target-specific delivery of cytotoxic ruthenium complexes to breast cancer cells with peptides (Oral Communication)". Trabalho apresentado em Radiopharmaceutical Sciences and Health Physics Workshop 2021, Lisbon (Online Conference), 2021.
  5. João Franco Machado; Machuqueiro, M.; Marques, F.; Garcia, M.H.; Correia, J.D.G.; Morais, T.S.. "New ruthenium-peptide conjugates for selective targeting of breast cancer (Oral Communication)". Trabalho apresentado em 3rd CQE Days Spring Meeting, Lisbon (Online Conference), 2021.
  6. Correia, J.D.G.; João Franco Machado; Marques, F.; Garcia, M.H.; Morais, T.S.. "Ruthenium-peptide conjugates for the selective treatment of triple-negative breast cancer (Oral Communication)". Trabalho apresentado em 17th Iberian Peptide Meeting, Madrid, 2020.
  7. João Franco Machado; Marques, F.; Piedade, M.F.M.; Villa Brito, M.J.; Garcia, M.H.; Morais, T.S.. "Copper(I)-phosphane complexes as promising anticancer agents (Oral Communication; ISBN: 978-989-8124-24-1)". Trabalho apresentado em XXIV Encontro Luso Galego de Química, Porto, 2018.
  8. João Franco Machado; Marques, F.; Piedade, M.F.M.; Garcia, M.H.; Morais, T.S.. "Synthesis and characterization of promising anticancer Cu(I) complexes (Oral Communication)". Trabalho apresentado em 10th Modern Methods of Structure Elucidation, Lisbon, 2018.
  9. João Franco Machado; Heinis, C.. "Diversification of peptide macrocycle libraries (Oral Communication)". Trabalho apresentado em LPPT/ EPFL Laboratory Retreat, Crans-Montana, 2017.
  10. João Franco Machado; Pontes, A.; Castro, M.; Costa, J.; Martins, M.L.; Cabral, M.F.. "Synthesis, potentiometric and antifungal studies of two thia-tetraaza macrocyclic ligands and their Cu(II) and Ni(II) complexes (Oral Communication; ISBN: 978-84-608-3441-0)". Trabalho apresentado em XXI Encontro Galego-Portugués de Química, Pontevedra, 2015.
  11. João Franco Machado; Costa, J.; Cabral, M.F.. "Dioxo-[14]aneN3S: a new macrocyclic compound & Macrocyclic chemistry research at iMed.ULisboa (Oral Communication)". Trabalho apresentado em CBT – iMed.ULisboa Meeting, Lisbon, 2015.
Tese / Dissertação
  1. "João Franco Machado. Novel ruthenium-peptide conjugates for precision therapy of metastatic breast cancer". Doutoramento, Universidade de Lisboa Faculdade de Ciências, 2024.
  2. João Franco Machado. "Development of a novel macrocyclic compound with in vitro antifungal activity". Mestrado, Universidade de Lisboa Faculdade de Farmácia, 2016. https://repositorio.ul.pt/handle/10451/35868.
  3. João Franco Machado. "Acid-base studies of two dioxo-thia-polyaza macrocyclic compounds by potentiometry and NMR spectroscopy". Licenciatura, Universidade de Lisboa Faculdade de Farmácia, 2015.
  4. João Franco Machado. "Dioxo-[14]aneN3S: a new macrocyclic compound". Licenciatura, Universidade de Lisboa Faculdade de Farmácia, 2015.

Propriedade Intelectual

Patente
  1. 2023. Morais, T.S.; Garcia, M.H.; João Franco Machado. 2023. "Organometallic complex, controlled-release multi-functional drug, pharmaceutical composition, processes for the preparation thereof and their use (WO 2023/199134 A1)".
Pedido provisório de patente
  1. 2022. "Morais, T.S.; Garcia, M.H.; João Franco Machado. Organometallic complex, controlled-release multi-functional drug, pharmaceutical composition, processes for the preparation thereof and their use (nr 20221000001619)".

Outros

Outra produção
  1. Front cover of Dalton Transactions journal (volume 53, number 18, pages 7645-8054, May 2024). Front cover artwork highlighting the paper "Dual FGFR-targeting and pH-activatable ruthenium–peptide conjugates for targeted therapy of breast cancer". 2024. João Franco Machado; Morais, T.S. https://doi.org/10.1039/D4DT90076F.
    10.1039/D4DT90076F
  2. Front cover of Dalton Transactions journal (volume 51, number 7, pages 2579-2978, February 2022). Front cover artwork highlighting the paper "Are smart delivery systems the solution to overcome the lack of selectivity of current metallodrugs in cancer therapy?". 2022. João Franco Machado; Morais, T.S. https://doi.org/10.1039/D2DT90026B.
    10.1039/D2DT90026B
  3. Article "Second edition of the Chem & Biochem Students Meeting". Química 2022, 166, 158-159. Article on the bulletin of the Portuguese Chemical Society (Química) about the 2nd edition of the Chem & Biochem Students Meeting held at Faculty of Sciences, University of Lisbon. 2022. Figueira, A.J.; João Franco Machado. https://doi.org/10.52590/M3.P703.
    10.52590/M3.P703
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2024/06/17 Invited Seminar: Laboratory diagnosis of kidney disease (Author & Corresponding author: João Franco Machado) Invited seminar given in the curricular unit Clinical Biochemistry II of the Master's Degree in Laboratory Medicine
Universidade de Lisboa Faculdade de Farmácia (Lisbon, Portugal)
2024/05/27 Invited Seminar: Factors impacting the laboratory turnaround time of high-sensitivity cardiac Troponin T testing in a Lisbon Hospital Centre (Authors: João Franco Machado; Fonseca, I.; Soares, J.; Cardoso, C.; Figueira, J.M; Azevedo, A.P. Corresponding author: João Franco Machado) Invited seminar given to the Clinical Chemistry and Immunology department of Roche Diagnostics Portugal
Roche Diagnostics (Lisbon, Portugal)
2023/07/13 Oral Communication: Innovative smart metallodrug delivery systems for targeted therapy of metastatic breast cancer (Authors: João Franco Machado; Silva, M.T.; Pires, I.; Marques, F.; Machuqueiro, M.; Garcia, M.H.; Correia, J.D.G.; Morais, T.S.) 3rd Chem&Biochem Students Meeting
Universidade de Lisboa Faculdade de Ciências (Lisbon, Portugal)
2022/05/27 Oral Communication: Hunting metastatic breast cancer with novel ruthenium smart metallodrug delivery systems (Authors: João Franco Machado; Duarte, J.N.; Silva, M.T.; Marques, F.; Mendes, F.B.; Garcia, M.H.; Correia, J.D.G.; Morais, T.S.) 4th CQE Days Spring Meeting
Universidade de Lisboa Centro de Química Estrutural (Lisbon, Portugal)
2022/05/04 Invited Seminar: From Pharmacy to Chemistry: the journey and the challenges (Author: João Franco Machado) Invited seminar given in the curricular unit Perspectives in Research and Development of the Bachelor's Degree in Chemistry, Bachelor's Degree in Technological Chemistry, and Bachelor's Degree in Biochemistry
Universidade de Lisboa Faculdade de Ciências (Lisbon, Portugal)
2021/07/08 Oral Communication: Target-specific delivery of cytotoxic ruthenium complexes to breast cancer cells with peptides (Authors: João Franco Machado; Machuqueiro, M.; Marques, F.; Garcia, M.H.; Correia, J.D.G.; Morais, T.S.) Radiopharmaceutical Sciences and Health Physics Workshop 2021
Universidade de Lisboa Centro de Ciências e Tecnologias Nucleares (Lisbon, Portugal)
2021/05/27 Oral Communication: New ruthenium-peptide conjugates for selective targeting of breast cancer (Authors: João Franco Machado; Machuqueiro, M.; Marques, F.; Garcia, M.H.; Correia, J.D.G.; Morais, T.S.) 3rd CQE Days Spring Meeting
Universidade de Lisboa Centro de Química Estrutural (Lisbon, Portugal)
2018/11/21 Oral Communication: Copper(I)-phosphane complexes as promising anticancer agents (Authors: João Franco Machado; Marques, F.; Piedade, M.F.M.; Villa Brito, M.J.; Garcia, M.H.; Morais, T.S.) XXIV Encontro Luso Galego de Química
Universidade do Porto Faculdade de Ciências (Porto, Portugal)
2018/10/18 Oral Communication: Synthesis and characterization of promising anticancer Cu(I) complexes (Authors: João Franco Machado; Marques, F.; Piedade, M.F.M.; Garcia, M.H.; Morais, T.S.) 10th Modern Methods of Structure Elucidation
Universidade de Lisboa Instituto Superior Técnico (Lisbon, Portugal)
2017/01/17 Oral Communication: Diversification of peptide macrocycle libraries (Authors: João Franco Machado; Heinis, C.) LPPT/ EPFL Laboratory Retreat
Hotel Valaisia (Crans-Montana, Suiça)
2015/11/18 Oral Communication: Synthesis, potentiometric and antifungal studies of two thia-tetraaza macrocyclic ligands and their Cu(II) and Ni(II) complexes (Authors: João Franco Machado; Pontes, A.; Castro, M.; Costa, J.; Martins, M.L.; Cabral, M.F.) XXI Encontro Galego-Portugués de Química
Pazo da Cultura (Pontevedra, Espanha)
2015/02/26 Oral Communication: Dioxo-[14]aneN3S: a new macrocyclic compound & Macrocyclic chemistry research at iMed.ULisboa (Authors: João Franco Machado; Costa, J.; Cabral, M.F.) CBT – iMed.ULisboa Meeting
Universidade de Lisboa Faculdade de Farmácia (Lisbon, Portugal)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2022/06 - 2022/07 Synthesis of Cu(I) complexes with potential anti-tumor application
Coorientador de Nishta Ramkhelawon
 Chemistry (Licenciatura/Bacharelato)
Sorbonne Université Faculté des Sciences et Ingénierie, França
2021/10 - 2022/07 New ruthenium complexes with antibiotics as potential bifunctional anticancer agents
Coorientador de Bárbara Marques
 Chemistry (Licenciatura/Bacharelato)
Universidade de Lisboa Faculdade de Ciências, Portugal
2020/10 - 2021/07 New organometallic complexes of Ruthenium for the treatment of breast cancer
Coorientador de Marco Sá
 Chemistry (Licenciatura/Bacharelato)
Universidade de Lisboa Faculdade de Ciências, Portugal
2019/09 - 2019/11 Ruthenium-peptide conjugates as potential anticancer agents
Coorientador de Sandra Deiser
 Chemistry (Mestrado)
Technische Universität München Fakultät für Chemie, Alemanha
2016/10 - 2017/02 Generation of macrocycle libraries by S-to-N macrocyclization
Coorientador de Lisa Bader
 Molecular and Biological Chemistry (Mestrado)
École polytechnique fédérale de Lausanne Faculté des sciences de base, Suiça

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2022/01 - 2022/07 Organisation of the 2nd Chem&Biochem Students Meeting at Lisbon, Portugal (250 participants; http://chembiochem02.campus.ciencias.ulisboa.pt/) (2022/07/15)
Conferência (Membro da Comissão Organizadora)
 Universidade de Lisboa Faculdade de Ciências, Portugal

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2013 - 2024 Participation in 27 national and international scientific meetings in the fields of Chemistry and Pharmacy
Congresso
2019/01 - 2019/01 Outreach Activity as Participant: Flash mob within the celebrations of the International Year of the Periodic Table (YPTB) at Faculty of Sciences, University of Lisbon (FCUL). Each participant (students, professors, and researchers) was identified as an Element of the Periodic Table and performed a collective flash mob on the Periodic Table paint located at FCUL (https://youtu.be/bmVMJoynb1Q)
Exposição
 Opening Ceremony of the 2019 International Year of the Periodic Table
Universidade de Lisboa Faculdade de Ciências, Portugal
2015/05 - 2016/07 Outreach Activities as Faculty Delegate (invited): Representation and promotion of the Faculty of Pharmacy and of the Integrated Master's degree in Pharmaceutical Sciences in several activities organised by the University of Lisbon, namely "FFULisboa Open Day", "Discover ULisboa" and "Summer at ULisboa"
Outro
Universidade de Lisboa Faculdade de Farmácia, Portugal

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2018/10 - 2019/07 Graduate Teaching Assistant: teaching of Inorganic Chemistry (laboratory) (Licenciatura) Universidade de Lisboa Faculdade de Ciências, Portugal
2016/10 - 2017/12 Teaching Assistant: teaching of Advanced General Chemistry (theoretical-practical), General Organic Chemistry (theoretical-practical), Molecular and Biological Chemistry (laboratory) (Bachelor) École polytechnique fédérale de Lausanne Faculté des sciences de base, Suiça
2012/09 - 2016/09 Monitor: collaboration in teaching of Analytical Chemistry (laboratory), and Pharmaceutical Chemistry (laboratory) (Mestrado integrado) Universidade de Lisboa Faculdade de Farmácia, Portugal

Entrevista (jornal / revista)

Descrição da atividade Jornal / Forum
2015/10 Interviewed by the European Pharmaceutical Students' Associationn EPSA Students Science Publication 2015, 3(1), 4. In: http://www.epsa-online.org/epsa-students-science-publication/

Membro de associação

Nome da associação Tipo de participação
2023/12 - Atual Portuguese Laboratory Medicine Society (Sociedade Portuguesa de Medicina Laboratorial) Affiliate member
2023/07 - Atual Portuguese Healthcare Pharmacists Society (Sociedade Portuguesa de Farmacêuticos dos Cuidados de Saúde) Member
2017/09 - Atual The Global Undergraduate Awards Alumni Network Member
2014/08 - Atual Portuguese Pharmacists Association (Ordem dos Farmacêuticos) Full-member (2016-present); Student-member (2014-2016)
2014/08 - Atual Portuguese Chemical Society (Sociedade Portuguesa de Química) Member

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2024/06 - 2024/09 Member of the Scientific Committee of "PRESFAR 2024" programme organized by the Portuguese Healthcare Pharmacists Society
Membro
 Portuguese Healthcare Pharmacists Society (Sociedade Portuguesa de Farmacêuticos dos Cuidados de Saúde), Portugal
2018/11 - 2022/11 Safety Delegate: Member of the safety and evacuation team of the Faculty of Sciences, University of Lisbon (responsible for the C8 building, 5C section), in straight collaboration with the Safety, Health and Sustainability Office of the Faculty
Membro
 Universidade de Lisboa Faculdade de Ciências, Portugal
2012/09 - 2013/07 Student's Representative (elected): member of the "Comissão de Curso" of the Integrated Master's degree in Pharmaceutical Sciences (Faculty of Pharmacy, University of Lisbon, Portugal) during the academic year of 2012/2013
Membro
 Universidade de Lisboa Faculdade de Farmácia, Portugal

Tutoria

Tópico Nome do aluno
2017 - 2019 Mentor (invited): scientific mentorship of students of the Integrated Master's degree in Pharmaceutical Sciences (mentorship programme organised by the Student's Association and the Pedagogical Council) Francisco Carvalho (2018/2019); Helena Vieira (2017/2018)
Distinções

Prémio

2022 Molecules-MDPI Best Oral Communication Award
Centro de Química Estrutural (4th CQE Days Spring Meeting with the sponsorship of Molecules-MDPI), Portugal
2017 Highly Commended in Chemical and Pharmaceutical Sciences 2017
The Global Undergraduate Awards (under the patronage of His Excellency the President of Ireland), Irlanda

Outra distinção

2024 Media citation: "Primeiros complexos de cobalto-ciclopentadienilo seletivos para o cancro"
Portuguese Association for Cancer Research (https://www.aspic.pt/pt-pt/noticias/primeiros-complexos-de-cobalto-ciclopentadienilo-seletivos-para-o-cancro), Portugal
2024 Scientific article selected as journal front cover
Paper «Dual FGFR-targeting and pH-activable Ruthenium-Peptide Conjugates for targeted therapy of Breast Cancer» (DOI: 10.1039/d4dt00497c) selected as front cover (DOI: 10.1039/D4DT90076F) by Dalton Transactions journal, Reino Unido
2023 Scientific article selected as «very important paper»
Paper «Copper(I)-Thiosemicarbazone Complexes with Dual Anticancer and Antiparasitic Activity» (DOI:10.1002/cmdc.202300074) selected as «very important paper» by ChemMedChem journal, Alemanha
2023 Media citation: "Copper(I) complexes as dual anticancer and antiparasitic agents"
ChemistryViews (https://www.chemistryviews.org/copperi-complexes-as-dual-anticancer-and-antiparasitic-agents), Alemanha
2023 Media citation: "Pedida patente para terapia de precisão do cancro da mama metastático”
Portuguese newspaper «Público» (https://www.publico.pt/2023/12/20/ciencia/noticia/pedida-patente-terapia-precisao-cancro-mama-metastatico-2074322) , Portugal
2022 Scientific article selected as journal front cover and as «hot topic»
Paper «Are smart delivery systems the solution to overcome the lack of selectivity of current metallodrugs in cancer therapy?» (DOI:10.1039/D1DT04079K) selected as front cover (DOI: 10.1039/D2DT90026B) and «hot topic» by Dalton Transactions journal, Reino Unido
2021 Media citation: "Arrows2cancer - ruthenium-peptide conjugates: arrows for selectively targeting breast cancer"
Portuguese Chemical Society: Bonifácio, V. Arrows2cancer - fármacos de ruténio-péptido: flechas para alvejar seletivamente o cancro da mama. Química. 2021, 161(45), 25. DOI: 10.52590/M3.P696, Portugal
2020 Scientific article selected as «hot topic»
Paper «New copper(I) complexes selective for prostate cancer cells» (DOI:10.1039/D0DT02157A) selected as «hot topic» by Dalton Transactions journal , Reino Unido
2019 Media citation: "New cyclization reactions for synthesizing macrocyclic drug leads"
Science Daily (https://www.sciencedaily.com/releases/2019/08/190821142721.htm), Estados Unidos
2018 PhD Studentship
Fundação para a Ciência e a Tecnologia, Portugal
2015 Shortlisted for the 2015 Gilead Award in Pharmaceutical Biotechnology
Gilead Sciences, França