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Hartmut Luecke is a structural biologist with an emphasis on membrane protein structure-function studies and structure-based drug discovery. He began his independent career at the Stanford Synchrotron as a Structural Biologist before joining the faculty at the University of California, Irvine (UC Irvine) in 1996, where he was Professor of Biochemistry, Biophysics and Computer Science for over 20 years. He is also the founding director of the UC Irvine Center for Biomembrane Systems. In 2017, he was appointed as Professor and Assistant Director at the Norwegian Center for Molecular Medicine / University of Oslo (NCMM/UiO) leading the group on Structural Biology and Drug Discovery. At the same time, he invested in setting up cryo-EM facilities at UiO, the first such infrastructure in Norway. His work has been published in journals such as Nature (4), Science (4), and Proc. Natl. Acad. Sci. USA (4) with an average number of 137 citations per publication (Google Scholar h-index: 43; total citations: 11,107).
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Identificação

Identificação pessoal

Nome completo
Hartmut Luecke

Nomes de citação

  • Luecke, Hartmut

Identificadores de autor

Ciência ID
CF16-57B0-3F1A
ORCID iD
0000-0002-4938-0775
Scopus Author Id
7006841486

Websites

Formação
Grau Classificação
1990
Concluído
 Biochemistry, emphasis in X-ray Crystallography (Doktor (PhD))
Rice University, Estados Unidos
1984
Concluído
 Chemistry, Physics & Computer Science (Bachelor)
Heidelberg College, Estados Unidos
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2023 - Atual Investigador Coordenador (carreira) (Investigação) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
1992 - 1996 Investigador (Investigação) Stanford Synchrotron Radiation Lightsource, Estados Unidos
1990 - 1992 Pós-doutorado (Investigação) Max-Planck-Institute for Biochemistry, Alemanha

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2017 - Atual Professor Catedrático (Docente Universitário) University of Oslo - Norwegian Center for Molecular Medicine, Noruega
2002 - 2017 Professor Catedrático (Docente Universitário) University of California Irvine Department of Biological Chemistry, Estados Unidos
1996 - 2002 Professor Associado (Docente Universitário) University of California Irvine Department of Biological Chemistry, Estados Unidos

Cargos e Funções

Categoria Profissional
Instituição de acolhimento 		Empregador
2017 - Atual Subdirector de Unidade Orgânica University of Oslo - Norwegian Center for Molecular Medicine, Noruega
2007 - 2017 Director de Unidade Orgânica University of California Irvine Department of Biological Chemistry, Estados Unidos
Center for Biomembrane Systems, Estados Unidos
Projetos

Bolsa

Designação Financiadores
2023/01 - 2027/12 CryoEM@NOVA: a cryo electron microscopy hub enabling drug discovery
101087571
 European Commission
2018/04 - 2021/05 Structure-Activity Relationship (SAR) studies of p53 cancer mutant reactivators
18-0640
 Worldwide Cancer Research
2008/02 - 2018/06 Structure-Function Studies of the Proton-Gated Urea Channel from H. Pylori
R01AI078000
 National Institute of Allergy and Infectious Diseases
2003/08 - 2008/07 The mechanism of signal transduction in photoreceptors
R01GM067808
 National Institute of General Medical Sciences
1997/01 - 2008/05 Structure-Function Studies of Annexin I and II
R01GM056445
 National Institute of General Medical Sciences
1999/09 - 2005/08 STRUCTURAL STUDIES OF THE BACTERIORHODOPSIN PHOTOCYCLE
R01GM059970
 National Institute of General Medical Sciences
1992/09 - 2002/08 BIOCARS A SYNCHROTRON STRUCTURAL BIOLOGY RESOURCE
U41RR007707
 National Center for Advancing Translational Sciences
1999/06 - 2001/06 Structure determination of retinoic acid receptors with bound ligands
DRT-S98-65
 US Geological Survey

Projeto

Designação Financiadores
2023/01/01 - 2023/12/31 Applied Molecular Biosciences Unit
UIDB/04378/2020
10.54499/UIDB/04378/2020
Investigador
Universidade Nova de Lisboa, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2023/01/01 - 2023/12/31 Applied Molecular Biosciences Unit
UIDP/04378/2020
10.54499/UIDP/04378/2020
Investigador
Universidade Nova de Lisboa, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em revista
  1. Cunha, E.S.; Chen, X.; Sanz-Gaitero, M.; Mills, D.J.; Luecke, H.. "Author Correction: Cryo-EM structure of Helicobacter pylori urease with an inhibitor in the active site at 2.0 Å resolution (Nature Communications, (2021), 12, 1, (230), 10.1038/s41467-020-20485-6)". Nature Communications 14 1 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85147460966&partnerID=MN8TOARS.
    10.1038/s41467-023-36404-4
  2. Leipart, V.; Montserrat-Canals, M.; Cunha, E.S.; Luecke, H.; Herrero-Galán, E.; Halskau, Ø.; Amdam, G.V.. "Structure prediction of honey bee vitellogenin: a multi-domain protein important for insect immunity". FEBS Open Bio 12 1 (2022): 51-70. http://www.scopus.com/inward/record.url?eid=2-s2.0-85118265991&partnerID=MN8TOARS.
    10.1002/2211-5463.13316
  3. Gutiérrez-Fernández, J.; Javaid, F.; De Rossi, G.; Chudasama, V.; Greenwood, J.; Moss, S.E.; Luecke, H.. "Structural basis of human LRG1 recognition by Magacizumab, a humanized monoclonal antibody with therapeutic potential". Acta Crystallographica Section D: Structural Biology 78 (2022): 725-734. http://www.scopus.com/inward/record.url?eid=2-s2.0-85131226899&partnerID=MN8TOARS.
    10.1107/S2059798322004132
  4. Cunha, E.S.; Chen, X.; Sanz-Gaitero, M.; Mills, D.J.; Luecke, H.. "Cryo-EM structure of Helicobacter pylori urease with an inhibitor in the active site at 2.0 Å resolution". Nature Communications 12 1 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85099234392&partnerID=MN8TOARS.
    10.1038/s41467-020-20485-6
  5. Rajappa-Titu, L.; Suematsu, T.; Munoz-Tello, P.; Long, M.; Demir, O.; Cheng, K.J.; Stagno, J.R.; et al. "RNA Editing TUTase 1: Structural foundation of substrate recognition, complex interactions and drug targeting". Nucleic Acids Research 44 22 (2016): 10862-10878. http://www.scopus.com/inward/record.url?eid=2-s2.0-85016146373&partnerID=MN8TOARS.
    10.1093/nar/gkw917
  6. Dong, B.; Sánchez-Magraner, L.; Luecke, H.. "Structure of an Inward Proton-Transporting Anabaena Sensory Rhodopsin Mutant: Mechanistic Insights". Biophysical Journal 111 5 (2016): 963-972. http://www.scopus.com/inward/record.url?eid=2-s2.0-84995581761&partnerID=MN8TOARS.
    10.1016/j.bpj.2016.04.055
  7. Kryshtafovych, A.; Moult, J.; Bales, P.; Bazan, J.F.; Biasini, M.; Burgin, A.; Chen, C.; et al. "Challenging the state of the art in protein structure prediction: Highlights of experimental target structures for the 10th critical assessment of techniques for protein structure prediction experiment CASP10". Proteins: Structure, Function and Bioinformatics 82 SUPPL.2 (2014): 26-42. http://www.scopus.com/inward/record.url?eid=2-s2.0-84893020987&partnerID=MN8TOARS.
    10.1002/prot.24489
  8. Wassman, C.D.; Baronio, R.; Demir, O.; Wallentine, B.D.; Chen, C.-K.; Hall, L.V.; Salehi, F.; et al. "Computational identification of a transiently open L1/S3 pocket for reactivation of mutant p53". Nature Communications 4 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84879147794&partnerID=MN8TOARS.
    10.1038/ncomms2361
  9. Ran, T.; Ozorowski, G.; Gao, Y.; Sineshchekov, O.A.; Wang, W.; Spudich, J.L.; Luecke, H.. "Cross-protomer interaction with the photoactive site in oligomeric proteorhodopsin complexes". Acta Crystallographica Section D: Biological Crystallography 69 10 (2013): 1965-1980. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885463382&partnerID=MN8TOARS.
    10.1107/S0907444913017575
  10. McNulty, R.; Ulmschneider, J.P.; Luecke, H.; Ulmschneider, M.B.. "Mechanisms of molecular transport through the urea channel of Helicobacter pylori". Nature Communications 4 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84890072910&partnerID=MN8TOARS.
    10.1038/ncomms3900
  11. Strugatsky, D.; McNulty, R.; Munson, K.; Chen, C.-K.; Michael Soltis, S.; Sachs, G.; Luecke, H.. "Structure of the proton-gated urea channel from the gastric pathogen Helicobacter pylori". Nature 493 7431 (2013): 255-258. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872146541&partnerID=MN8TOARS.
    10.1038/nature11684
  12. Ozorowski, G.; Milton, S.; Luecke, H.. "Structure of a C-terminal AHNAK peptide in a 1:2:2 complex with S100A10 and an acetylated N-terminal peptide of annexin A2". Acta Crystallographica Section D: Biological Crystallography 69 1 (2013): 92-104. http://www.scopus.com/inward/record.url?eid=2-s2.0-84871884783&partnerID=MN8TOARS.
    10.1107/S0907444912043429
  13. Wallentine, B.D.; Wang, Y.; Tretyachenko-Ladokhina, V.; Tan, M.; Senear, D.F.; Luecke, H.. "Structures of oncogenic, suppressor and rescued p53 core-domain variants: Mechanisms of mutant p53 rescue". Acta Crystallographica Section D: Biological Crystallography 69 10 (2013): 2146-2156. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885443985&partnerID=MN8TOARS.
    10.1107/S0907444913020830
  14. Ozorowski, G.; Ryan, C.M.; Whitelegge, J.P.; Luecke, H.. "Withaferin A binds covalently to the N-terminal domain of annexin A2". Biological Chemistry 393 10 (2012): 1151-1163. http://www.scopus.com/inward/record.url?eid=2-s2.0-84869479021&partnerID=MN8TOARS.
    10.1515/hsz-2012-0184
  15. Arai, H.; Glabe, C.; Luecke, H.. "Crystal structure of a conformation-dependent rabbit IgG Fab specific for amyloid prefibrillar oligomers". Biochimica et Biophysica Acta - General Subjects 1820 12 (2012): 1908-1914. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866649947&partnerID=MN8TOARS.
    10.1016/j.bbagen.2012.08.016
  16. Nazmi, A.R.; Ozorowski, G.; Pejic, M.; Whitelegge, J.P.; Gerke, V.; Luecke, H.. "N-terminal acetylation of annexin A2 is required for S100A10 binding". Biological Chemistry 393 10 (2012): 1141-1150. http://www.scopus.com/inward/record.url?eid=2-s2.0-84869471258&partnerID=MN8TOARS.
    10.1515/hsz-2012-0179
  17. Nash, A.I.; McNulty, R.; Shillito, M.E.; Swartz, T.E.; Bogomolni, R.A.; Luecke, H.; Gardner, K.H.. "Erratum: Structural basis of photosensitivity in a bacterial light-oxygen-voltage/ helix-turn-helix (LOV-HTH) DNA-binding protein (Proceedings of the National Academy of Sciences of the United States of America (2011) 108, 23 (9449-9454) DOI: 10.1073/pnas.1100262108)". Proceedings of the National Academy of Sciences of the United States of America 109 15 (2012): 5904-5904. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859607992&partnerID=MN8TOARS.
    10.1073/pnas.1204100109
  18. Spudich, E.N.; Ozorowski, G.; Schow, E.V.; Tobias, D.J.; Spudich, J.L.; Luecke, H.. "A transporter converted into a sensor, a phototaxis signaling mutant of bacteriorhodopsin at 3.0 Å". Journal of Molecular Biology 415 3 (2012): 455-463. http://www.scopus.com/inward/record.url?eid=2-s2.0-84855835025&partnerID=MN8TOARS.
    10.1016/j.jmb.2011.11.025
  19. Nash, A.I.; McNulty, R.; Shillito, M.E.; Swartz, T.E.; Bogomolni, R.A.; Luecke, H.; Gardner, K.H.. "Structural basis of photosensitivity in a bacterial light-oxygen-voltage/ helix-turn-helix (LOV-HTH) DNA-binding protein". Proceedings of the National Academy of Sciences of the United States of America 108 23 (2011): 9449-9454. http://www.scopus.com/inward/record.url?eid=2-s2.0-79959354169&partnerID=MN8TOARS.
    10.1073/pnas.1100262108
  20. Stagno, J.; Aphasizheva, I.; Bruystens, J.; Luecke Hartmut, H.; Aphasizhev, R.. "Structure of the mitochondrial editosome-like complex associated TUTase 1 reveals divergent mechanisms of UTP selection and domain organization". Journal of Molecular Biology 399 3 (2010): 464-475. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954760175&partnerID=MN8TOARS.
    10.1016/j.jmb.2010.04.021
  21. Pathuri, P.; Nguyen, E.T.; Ozorowski, G.; Svärd, S.G.; Luecke, H.. "Apo and Calcium-Bound Crystal Structures of Cytoskeletal Protein Alpha-14 Giardin (Annexin E1) from the Intestinal Protozoan Parasite Giardia lamblia". Journal of Molecular Biology 385 4 (2009): 1098-1112. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149333150&partnerID=MN8TOARS.
    10.1016/j.jmb.2008.11.012
  22. Pathuri, P.; Vogeley, L.; Luecke, H.. "Crystal Structure of Metastasis-Associated Protein S100A4 in the Active Calcium-Bound Form". Journal of Molecular Biology 383 1 (2008): 62-77. http://www.scopus.com/inward/record.url?eid=2-s2.0-52049083050&partnerID=MN8TOARS.
    10.1016/j.jmb.2008.04.076
  23. Luecke, H.; Schobert, B.; Stagno, J.; Imasheva, E.S.; Wang, J.M.; Balashov, S.P.; Lanyi, J.K.. "Crystallographic structure of xanthorhodopsin, the light-driven proton pump with a dual chromophore". Proceedings of the National Academy of Sciences of the United States of America 105 43 (2008): 16561-16565. http://www.scopus.com/inward/record.url?eid=2-s2.0-55949126022&partnerID=MN8TOARS.
    10.1073/pnas.0807162105
  24. Vogeley, L.; Trivedi, V.D.; Sineshchekov, O.A.; Spudich, E.N.; Spudich, J.L.; Luecke, H.. "Crystal Structure of the Anabaena Sensory Rhodopsin Transducer". Journal of Molecular Biology 367 3 (2007): 741-751. http://www.scopus.com/inward/record.url?eid=2-s2.0-33847300912&partnerID=MN8TOARS.
    10.1016/j.jmb.2006.11.074
  25. Pathuri, P.; Nguyen, E.T.; Svärd, S.G.; Luecke, H.. "Apo and Calcium-bound Crystal Structures of Alpha-11 Giardin, an Unusual Annexin from Giardia lamblia". Journal of Molecular Biology 368 2 (2007): 493-508. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947595016&partnerID=MN8TOARS.
    10.1016/j.jmb.2007.02.016
  26. Stagno, J.; Aphasizheva, I.; Rosengarth, A.; Luecke, H.; Aphasizhev, R.. "UTP-bound and Apo Structures of a Minimal RNA Uridylyltransferase". Journal of Molecular Biology 366 3 (2007): 882-899. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846634055&partnerID=MN8TOARS.
    10.1016/j.jmb.2006.11.065
  27. Wang, Y.; Rosengarth, A.; Luecke, H.. "Structure of the human p53 core domain in the absence of DNA". Acta Crystallographica Section D: Biological Crystallography 63 3 (2007): 276-281. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947304781&partnerID=MN8TOARS.
    10.1107/S0907444906048499
  28. Stagno, J.; Aphasizheva, I.; Aphasizhev, R.; Luecke, H.. "Dual role of the RNA substrate in selectivity and catalysis by terminal uridylyl transferases". Proceedings of the National Academy of Sciences of the United States of America 104 37 (2007): 14634-14639. http://www.scopus.com/inward/record.url?eid=2-s2.0-35548937853&partnerID=MN8TOARS.
    10.1073/pnas.0704259104
  29. King, A.R.; Duranti, A.; Tontini, A.; Rivara, S.; Rosengarth, A.; Clapper, J.R.; Astarita, G.; et al. "URB602 Inhibits Monoacylglycerol Lipase and Selectively Blocks 2-Arachidonoylglycerol Degradation in Intact Brain Slices". Chemistry and Biology 14 12 (2007): 1357-1365. http://www.scopus.com/inward/record.url?eid=2-s2.0-37149011506&partnerID=MN8TOARS.
    10.1016/j.chembiol.2007.10.017
  30. Vogeley, L.; Luecke, H.. "Crystallization, X-ray diffraction analysis and SIRAS/molecular-replacenent phasing of three crystal forms of Anabaena sensory rhodopsin transducer". Acta Crystallographica Section F: Structural Biology and Crystallization Communications 62 4 (2006): 388-391. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645796433&partnerID=MN8TOARS.
    10.1107/S1744309106008359
  31. Pathuri, P.; Nguyen, E.T.; Luecke, H.. "Expression, purification, crystallization and preliminary X-ray diffraction analysis of a-11 giardin from Giardia lamblia". Acta Crystallographica Section F: Structural Biology and Crystallization Communications 62 11 (2006): 1108-1112. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750577924&partnerID=MN8TOARS.
    10.1107/S1744309106039650
  32. Trakhanov, S.; Vyas, N.K.; Luecke, H.; Kristensen, D.M.; Ma, J.; Quiocho, F.A.. "Ligand-free and -bound structures of the binding protein (LivJ) of the Escherichia coli ABC leucine/isoleucine/valine transport system: Trajectory and dynamics of the interdomain rotation and ligand specificity". Biochemistry 44 17 (2005): 6597-6608. http://www.scopus.com/inward/record.url?eid=2-s2.0-17844398488&partnerID=MN8TOARS.
    10.1021/bi047302o
  33. Appleby, T.C.; Luecke, H.; Jae, H.S.; Wu, J.Z.; Cheney, I.W.; Zhong, W.; Vogeley, L.; Hong, Z.; Yao, N.. "Crystal structure of complete rhinovirus RNA polymerase suggests front loading of protein primer". Journal of Virology 79 1 (2005): 277-288. http://www.scopus.com/inward/record.url?eid=2-s2.0-10644250663&partnerID=MN8TOARS.
    10.1128/JVI.79.1.277-288.2005
  34. Edmonds, B.W.; Luecke, H.. "Atomic resolution structures and the mechanism of ion pumping in bacteriorhodopsin". Frontiers in Bioscience 9 (2004): 1556-1566. http://www.scopus.com/inward/record.url?eid=2-s2.0-2442656919&partnerID=MN8TOARS.
    10.2741/1264
  35. Freites, J.A.; Ali, S.; Rosengarth, A.; Luecke, H.; Dennin, M.B.. "Annexin A1 interaction with a zwitterionic phospholipid monolayer: A fluorescence microscopy study". Langmuir 20 26 (2004): 11674-11683. http://www.scopus.com/inward/record.url?eid=2-s2.0-11144225827&partnerID=MN8TOARS.
    10.1021/la049713b
  36. Vogeley, L.; Sineshchekov, O.A.; Trivedi, V.D.; Sasaki, J.; Spudich, J.L.; Luecke, H.. "Anabaena sensory rhodopsin: A photochromic color sensor at 2.0 Å". Science 306 5700 (2004): 1390-1393. http://www.scopus.com/inward/record.url?eid=2-s2.0-8844250818&partnerID=MN8TOARS.
    10.1126/science.1103943
  37. Cartailler, J.-P.; Luecke, H.. "Structural and Functional Characterization of p Bulges and Other Short Intrahelical Deformations". Structure 12 1 (2004): 133-144. http://www.scopus.com/inward/record.url?eid=2-s2.0-1642534352&partnerID=MN8TOARS.
    10.1016/j.str.2003.12.001
  38. Prosise, G.L.; Luecke, H.. "Crystal structures of Tritrichomonas foetus inosine monophosphate dehydrogenase in complex with substrate, cofactor and analogs: A structural basis for the random-in ordered-out kinetic mechanism". Journal of Molecular Biology 326 2 (2003): 517-527. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037435776&partnerID=MN8TOARS.
    10.1016/S0022-2836(02)01383-9
  39. Rosengarth, A.; Luecke, H.. "A calcium-driven conformational switch of the N-terminal and core domains of annexin A1". Journal of Molecular Biology 326 5 (2003): 1317-1325. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037424618&partnerID=MN8TOARS.
    10.1016/S0022-2836(03)00027-5
  40. Fu, J.; Gaetani, S.; Oveisi, F.; Lo Verme, J.; Serrano, A.; De Fonseca, F.R.; Rosengarth, A.; et al. "Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-a". Nature 425 6953 (2003): 90-93. http://www.scopus.com/inward/record.url?eid=2-s2.0-0041321275&partnerID=MN8TOARS.
    10.1038/nature01921
  41. Tran, J.T.; Rosengarth, A.; Luecke, H.. "Cloning, purification and crystallization of full-length human annexin 2". Acta Crystallographica Section D: Biological Crystallography 58 10 I (2002): 1854-1857. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036794361&partnerID=MN8TOARS.
    10.1107/S0907444902013288
  42. Spudich, J.L.; Luecke, H.. "Sensory rhodopsin II: Functional insights from structure". Current Opinion in Structural Biology 12 4 (2002): 540-546. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036667744&partnerID=MN8TOARS.
    10.1016/S0959-440X(02)00359-7
  43. Prosise, G.L.; Zhen Wu, J.; Luecke, H.. "Crystal structure of Tritrichomonas foetus inosine monophosphate dehydrogenase in complex with the inhibitor ribavirin monophosphate reveals a catalysis-dependent ion-binding site". Journal of Biological Chemistry 277 52 (2002): 50654-50659. http://www.scopus.com/inward/record.url?eid=2-s2.0-0347297575&partnerID=MN8TOARS.
    10.1074/jbc.M208330200
  44. Abdulaev, N.G.; Strassmaier, T.T.; Ngo, T.; Chen, R.; Luecke, H.; Oprian, D.D.; Ridge, K.D.. "Grafting segments from the extracellular surface of CCR5 onto a bacteriorhodopsin transmembrane scaffold confers HIV-1 coreceptor activity". Structure 10 4 (2002): 515-525. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036223247&partnerID=MN8TOARS.
    10.1016/S0969-2126(02)00752-9
  45. Rosengarth, A.; Gerke, V.; Luecke, H.. "X-ray structure of full-length annexin 1 and implications for membrane aggregation". Journal of Molecular Biology 306 3 (2001): 489-498. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035936691&partnerID=MN8TOARS.
    10.1006/jmbi.2000.4423
  46. Rouhani, S.; Cartailler, J.-P.; Facciotti, M.T.; Walian, P.; Needleman, R.; Lanyi, J.K.; Glaeser, R.M.; Luecke, H.. "Crystal structure of the D85S mutant of bacteriorhodopsin: Model of an O-like photocycle intermediate". Journal of Molecular Biology 313 3 (2001): 615-628. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035955561&partnerID=MN8TOARS.
    10.1006/jmbi.2001.5066
  47. Luecke, H.; Schobert, B.; Lanyi, J.K.; Spudich, E.N.; Spudich, J.L.. "Crystal structure of sensory rhodopsin II at 2.4 angstroms: Insights into color tuning and transducer interaction". Science 293 5534 (2001): 1499-1503. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035943457&partnerID=MN8TOARS.
    10.1126/science.1062977
  48. Lanyi, J.K.; Luecke, H.. "Bacteriorhodopsin". Current Opinion in Structural Biology 11 4 (2001): 415-419. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035425498&partnerID=MN8TOARS.
    10.1016/S0959-440X(00)00226-8
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Livro
  1. Luecke, H.; Lanyi, J.K.. Structural clues to the mechanism of ion pumping in bacteriorhodopsin. 2003.
    10.1016/S0065-3233(03)63005-6
  2. Cartailler, J.-P.; Luecke, H.. X-ray crystallographic analysis of lipid-protein interactions in the bacteriorhodopsin purple membrane. 2003.
    10.1146/annurev.biophys.32.110601.142516

Outros

Outra produção
  1. High resolution analysis of proteolytic substrate processing. 2022. Schillinger, J.; Koci, M.; Bravo-Rodriguez, K.; Heilmann, G.; Kaschani, F.; Kaiser, M.; Beuck, C.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85128897396&partnerID=MN8TOARS.
    10.1101/2022.03.24.485615
  2. Cryo-EM structure of Helicobacter pylori urease with a novel inhibitor in the active site at 2.0 Å resolution. 2020. Cunha, E.S.; Chen, X.; Gaitero, M.S.; Mills, D.J.; Luecke, H.. http://www.scopus.com/inward/record.url?eid=2-s2.0-85098893817&partnerID=MN8TOARS.
    10.1101/2020.09.14.290999
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2023/11 Cryo-Electron Microscopy: Structural Biology at Atomic Resolution NOVA Science and Innovation Day
(Portugal)
2023/09 Drug discovery with Cryo EM: targeting Helicobacter pylori GlycoTwinning Summer School
(Portugal)
2023/05 Helicobacter pylori Acid Acclimation: The Evil Duo of a pH-Gated Urea Channel and a Cytoplasmic Urease 8th Internacional School on Biological Crystallization
(Espanha)
2022/03 Structural Insights in Membrane Protein Function
Gordon Research Seminar (Itália)
2021/08 ADVANCED METHODS IN MACROMOLECULAR CRYSTALLIZATION FEBS Advanced Course
(República Checa)
2021/06 Cryo-EM structure of Helicobacter pylori urease with an inhibitor in the active site at 1.68¿Å resolution Cryo-EM and Drug Development
SciLifeLab Symposium (Suécia)
2021/06 Proton transport and proton-coupled transport 13Th European Biophysics Conferene: EBSA Satellite Meeting
(Áustria)
2021/02 Helicobacter pylori chronic infection:The evil duo of a pH-gated urea channel and a cytoplasmic Urease ALBA II Colloquium #4 - "Multilength scale imaging with cryo-EM"
ALBA synchtron (Espanha)
2018/09 Helicobacter pylori Acid Acclimation: The Evil Duo of a pH-Gated Urea Channel and a Cytoplasmic Urease Nordic EMBL Meeting
2018/03 Helicobacter Pylori pH Acclimation: The Evil Duo of a pH-Gated Urea Channel and a Cytoplasmic Urease Molecular Mechanisms of Transporters, Ion Channels, and G-Protein Coupled Receptors
(Estados Unidos)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2023/09/01 - Atual Structural, dynamics and mechanistic studies of two enzymatic systems with environmental and biotechnological impact
Coorientador
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019 - 2021 Structural biology and drug discovery: Infectious diseases / Stomach cancer
Orientador
 Postdoc
University of Oslo - Norwegian Center for Molecular Medicine, Noruega
2019 - 2021 Compounds for reactivation of p53 tumor suppressor function in various cancers
Orientador
 Postdoc
University of Oslo - Norwegian Center for Molecular Medicine, Noruega
2019 - 2021 Structure-Function studies and inhibitor discovery targeting the cytoplasmic urease from H. pylori
Orientador
 Postdoc
University of Oslo - Norwegian Center for Molecular Medicine, Noruega
Distinções

Prémio

2003 Friedrich Wilhelm Bessel Science Prize, AvH Foundation

Título

2014 Member of the Council of the International Organization for Biological Crystallization
2012 Fellow of the American Association for Advancement of Science (AAAS)