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Bárbara Rocha is an Assistant Professor at the Faculty of Pharmacy, University of Coimbra. She has a BSc in Pharmaceutical Sciences, a MSc degree in Medicine (University of Coimbra) and a PhD in Pharmaceutical Sciences (University of Coimbra). In collaboration with research groups at the University of La República (Uruguay) and the Karolinska Institute (Sweden) she studied the biochemical interactions of dietary polyphenols and nitrate in the murine and human stomach, establishing the proof of concept that phenols promote the non-enzymatic production of nitric oxide in the gastric environment upon a meal containing green vegetables. Moreover, she demonstrated that upon production in the gastric lumen, nitric oxide diffuses towards the gastric mucosa and induces smooth muscle relaxation, likely modulating the rate of gastric emptying. Then, Barbara Rocha studied post-translational modifications of gastric proteins induced by dietary nitrate and nitrite. She has shown that pepsin (gastric protease) is nitrated and inactivated by dietary nitrate in the stomach in vivo and that nitrated pepsin prevents the development of peptic ulcers. She later did a postdoc at University of Coimbra where she investigated the impact of dietary nitrate on gut and systemic physiological mechanisms upon antibiotic therapy by modulating gut microbiota. Currently, she is studying the impact of antibiotics on gut microbiota and gastrointestinal welfare at clinical level in collaboration with the Gastroenterology department of Coimbra University Hospital. Barbara Rocha has been team member of several FCT-funded projects and is a past member of EuroSurg, an European medical students and surgeons network that collaborates to run multicentre international studies. She has been awarded with the Early Career Research Fellowship (2022) by the Society for Free Radical Research Europe/Oxygen Club of California (OCC) and with the "Future of Redox Biology" award by OCC (2022). Barbara Rocha has supervised undergraduate and master students and is currently co-supervising two PhD students and one master student.
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Identificação

Identificação pessoal

Nome completo
Barbara Rocha

Nomes de citação

  • Rocha, Barbara S
  • Rocha, BS

Identificadores de autor

Ciência ID
DD1A-4D76-62F0
Researcher Id
M-7768-2014
Scopus Author Id
24339269500

Telefones

Telefone
  • (+351) 239488400 (Profissional)

Moradas

  • Faculty of Pharmacy, University of Coimbra, Polo das Ciências da Saúde, Azinhaga Sta. Comba , 3000-548, Coimbra, Coimbra, Portugal (Profissional)

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Clínica - Gastrenterologia e Hepatologia
  • Ciências Médicas e da Saúde - Medicina Básica - Fisiologia
  • Ciências Naturais - Ciências Biológicas - Biologia Celular
  • Ciências Naturais - Ciências Biológicas - Bioquímica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Espanhol; Castelhano Utilizador independente (B1) Utilizador proficiente (C1) Utilizador independente (B1) Utilizador independente (B1)
Formação
Grau Classificação
2012 - 2018
Concluído
 Master in Medicine (Mestrado integrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
 17 (out of 20)
2008 - 2012
Concluído
 PhD in Pharmacy (Doutoramento)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2001 - 2007
Concluído
 Bachelor degree (6 years) in Pharmaceutical Sciences (Licenciatura)
Universidade de Coimbra Faculdade de Farmácia, Portugal
 16 (out of 20)
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2013/06/01 - 2018/08/31 Pós-doutorado (Investigação) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2007/01/10 - 2008/09/30 Investigador (Investigação) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2018/09/01 - Atual Professor Auxiliar (Docente Universitário) Universidade de Coimbra Faculdade de Farmácia, Portugal
Projetos

Bolsa

Designação Financiadores
2023/03/01 - 2026/02/28 The Neurovascular Coupling as a biomarker and a target for cognitive enhancement in aging and vascular dementia through an innovative dietary nitrate-driven nitric oxide redox cycle: a translational study
2022.05454.PTDC
Investigador
Fundação para a Ciência e a Tecnologia, Portugal
Em curso
2021/03/15 - 2024/03/14 Helicobacter Pylori Eradication Therapy in Portugal: Prospective, randomized, blind and multicentre trial on the efficacy of quadruple therapies and their clinical impact and immunological, oral and gut microbiota changes
PTDC/MEC-GAS/7361/2020
Investigador
2022/05/01 - 2023/12/01 The impact of redox signaling on microbiota-gut-brain communication: sheding light on how dietary nitrate signals from the gut to the brain
ECR-2022
Investigador responsável
The Oxygen Club of California, Estados Unidos

Society for Free Radical Biology and Medicine - Europe, Reino Unido
Concluído

Projeto

Designação Financiadores
2021/01/01 - 2025/12/31 Center for Innovative Biomedicine and Biotechnology - Associate Laboratory
LA/P/0058/2020
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2019/01/01 - 2019/12/31 CNC. IBILI
UID/NEU/04539/2019
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal

Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2011/01/01 - 2012/12/31 Strategic Project - LA 1 - 2011-2012
PEst-C/SAU/LA0001/2011
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em revista
  1. Gonçalves, João S.; Marçal, Ana L.; Marques, Bárbara S.; Costa, Filipa D.; Laranjinha, João; Rocha, Bárbara S.; Lourenço, Cátia F.. Autor correspondente: Rocha, Bárbara S.. "Dietary nitrate supplementation and cognitive health: the nitric oxide-dependent neurovascular coupling hypothesis". Biochemical Society Transactions (2024): http://dx.doi.org/10.1042/bst20230491.
    10.1042/bst20230491
  2. Reis, Ana; Rocha, Barbara S.; Laranjinha, João; de Freitas, Victor. "Dietary (poly)phenols as modulators of the biophysical properties in endothelial cell membranes: its impact on nitric oxide bioavailability in hypertension". FEBS Letters (2024): http://dx.doi.org/10.1002/1873-3468.14812.
    10.1002/1873-3468.14812
  3. Paiva, Beatriz; Laranjinha, João; Rocha, Barbara S. "Are oral and gut microbiota communicating through redox pathways? A novel asset of the nitrate-nitrite-NO pathway". FEBS Letters (2024):
    No prelo
  4. Reva, Katerina; Laranjinha, João; Rocha, Bárbara S.. "Epigenetic Modifications Induced by the Gut Microbiota May Result from What We Eat: Should We Talk about Precision Diet in Health and Disease?". Metabolites 13 3 (2023): 375. http://dx.doi.org/10.3390/metabo13030375.
    10.3390/metabo13030375
  5. Fraga, César G.; Trostchansky, Andrés; Rocha, Barbara S.; Laranjinha, João; Rubbo, Homero; Galleano, Monica. "(Poly)phenols and nitrolipids: Relevant participants in nitric oxide metabolism". Molecular Aspects of Medicine 89 (2023): 101158. http://dx.doi.org/10.1016/j.mam.2022.101158.
    10.1016/j.mam.2022.101158
  6. Ahmed, W. U. R.; Bhatia, S.; McLean, K. A.; Khaw, R.; Baker, D.; Kamarajah, S. K.; Bell, S.; et al. "Validation of the OAKS prognostic model for acute kidney injury after gastrointestinal surgery". BJS Open 6 1 (2022): http://dx.doi.org/10.1093/bjsopen/zrab150.
    10.1093/bjsopen/zrab150
  7. Rocha, Barbara S; 3014-5272-6F5D. "Precision diet: tuning human gut microbiota to modulate epigenetic modifications in health and disease". European Journal of Nutrition (2022):
    Em revisão
  8. Rocha, Bárbara S.. "The Nitrate-Nitrite-Nitric Oxide Pathway on Healthy Ageing: A Review of Pre-clinical and Clinical Data on the Impact of Dietary Nitrate in the Elderly". Frontiers in Aging 2 (2021): http://dx.doi.org/10.3389/fragi.2021.778467.
    10.3389/fragi.2021.778467
  9. Trindade, Inês A.; Pereira, Joana; Galhardo, Ana; Ferreira, Nuno B.; Lucena-Santos, Paola; Carvalho, Sérgio A.; Oliveira, Sara; et al. "The LIFEwithIBD Intervention: Study Protocol for a Randomized Controlled Trial of a Face-to-Face Acceptance and Commitment Therapy and Compassion-Based Intervention Tailored to People With Inflammatory Bowel Disease". Frontiers in Psychiatry 12 (2021): http://dx.doi.org/10.3389/fpsyt.2021.699367.
    10.3389/fpsyt.2021.699367
  10. Laranjinha, João; Nunes, Carla; Ledo, Ana; Lourenço, Cátia; Rocha, Bárbara; Barbosa, Rui M.. "The Peculiar Facets of Nitric Oxide as a Cellular Messenger: From Disease-Associated Signaling to the Regulation of Brain Bioenergetics and Neurovascular Coupling". Neurochemical Research (2021): http://dx.doi.org/10.1007/s11064-020-03015-0.
    10.1007/s11064-020-03015-0
  11. Glasbey, JC; Bibi, S; Pata, F; Ozkan, BB; Van Straten, S; Hodson, J; Chapman, SJ; et al. "Timing of nasogastric tube insertion and the risk of postoperative pneumonia: an international, prospective cohort study". Colorectal Disease 22 12 (2020): 2288-2297. http://dx.doi.org/10.1111/codi.15311.
    10.1111/codi.15311
  12. Rocha, Bárbara S.; Laranjinha, João. "Nitrate from diet might fuel gut microbiota metabolism: Minding the gap between redox signaling and inter-kingdom communication". Free Radical Biology and Medicine 149 (2020): 37-43. http://dx.doi.org/10.1016/j.freeradbiomed.2020.02.001.
    10.1016/j.freeradbiomed.2020.02.001
  13. Chapman, S J; Blanco-Colino, R; Pérez-Ajates, S; Bautista, O Anabitarte; Hodson, J; Glasbey, J C; Pata, F; et al. "Safety of hospital discharge before return of bowel function after elective colorectal surgery". British Journal of Surgery 107 5 (2020): 552-559. http://dx.doi.org/10.1002/bjs.11422.
    10.1002/bjs.11422
  14. Chapman, SJ; Clerc, D; Blanco-Colino, R; Otto, A; Nepogodiev, D; Pagano, G; Schaeff, V; et al. "Safety and efficacy of non-steroidal anti-inflammatory drugs to reduce ileus after colorectal surgery". British Journal of Surgery (2019): http://dx.doi.org/10.1002/bjs.11326.
    10.1002/bjs.11326
  15. Rocha, Bárbara S.; Correia, Mariana G.; Pereira, Anabela; Henriques, Isabel; Da Silva, Gabriela J.; Laranjinha, João. "Inorganic nitrate prevents the loss of tight junction proteins and modulates inflammatory events induced by broad-spectrum antibiotics: A role for intestinal microbiota?". Nitric Oxide 88 (2019): 27-34. http://dx.doi.org/10.1016/j.niox.2019.04.001.
    10.1016/j.niox.2019.04.001
  16. Rocha, Bárbara S.; Nunes, Carla; Laranjinha, João. "Tuning constitutive and pathological inflammation in the gut via the interaction of dietary nitrate and polyphenols with host microbiome". The International Journal of Biochemistry & Cell Biology 81 (2016): 393-402. http://dx.doi.org/10.1016/j.biocel.2016.10.021.
    10.1016/j.biocel.2016.10.021
  17. Rocha, Bárbara S.; Correia, Mariana G.; Fernandes, Rita C.; Gonçalves, João S.; Laranjinha, João. "Dietary nitrite induces occludin nitration in the stomach". Free Radical Research 50 11 (2016): 1257-1264. http://dx.doi.org/10.1080/10715762.2016.1234049.
    10.1080/10715762.2016.1234049
  18. Rocha, Bárbara S.; Lundberg, Jon O; Radi, Rafael; Laranjinha, João. "Role of nitrite, urate and pepsin in the gastroprotective effects of saliva". Redox Biology 8 (2016): 407-414. http://dx.doi.org/10.1016/j.redox.2016.04.002.
    10.1016/j.redox.2016.04.002
  19. Rocha, Bárbara S.; Gago, Bruno; Barbosa, Rui M.; Cavaleiro, Carlos; Laranjinha, João. "Ethyl nitrite is produced in the human stomach from dietary nitrate and ethanol, releasing nitric oxide at physiological pH: potential impact on gastric motility". Free Radical Biology and Medicine 82 (2015): 160-166. http://dx.doi.org/10.1016/j.freeradbiomed.2015.01.021.
    10.1016/j.freeradbiomed.2015.01.021
  20. Rocha, Bárbara S.; Nunes, Carla; Pereira, Cassilda; Barbosa, Rui M.; Laranjinha, João. "A shortcut to wide-ranging biological actions of dietary polyphenols: modulation of the nitrate–nitrite–nitric oxide pathway in the gut". Food & Function 5 8 (2014): 1646-1652. http://dx.doi.org/10.1039/c4fo00124a.
    10.1039/c4fo00124a
  21. Rocha, Bárbara S.; Gago, Bruno; Barbosa, Rui M.; Lundberg, Jon O.; Mann, Giovanni E.; Radi, Rafael; Laranjinha, João. "Pepsin is nitrated in the rat stomach, acquiring antiulcerogenic activity: A novel interaction between dietary nitrate and gut proteins". Free Radical Biology and Medicine 58 (2013): 26-34. http://dx.doi.org/10.1016/j.freeradbiomed.2012.12.017.
    10.1016/j.freeradbiomed.2012.12.017
  22. Pereira, Cassilda; Ferreira, Nuno R.; Rocha, Bárbara S.; Barbosa, Rui M.; Laranjinha, João. "The redox interplay between nitrite and nitric oxide: From the gut to the brain". Redox Biology 1 1 (2013): 276-284. http://dx.doi.org/10.1016/j.redox.2013.04.004.
    10.1016/j.redox.2013.04.004
  23. Rocha, Bárbara S.; Gago, Bruno; Barbosa, Rui M.; Lundberg, Jon O.; Radi, Rafael; Laranjinha, João. "Intragastric nitration by dietary nitrite: Implications for modulation of protein and lipid signaling". Free Radical Biology and Medicine 52 3 (2012): 693-698. http://dx.doi.org/10.1016/j.freeradbiomed.2011.11.011.
    10.1016/j.freeradbiomed.2011.11.011
  24. S. Rocha, Barbara; Gago, Bruno; Pereira, Cassilda; M. Barbosa, Rui; Bartesaghi, Silvina; O. Lundberg, Jon; Radi, Rafael; Laranjinha, Joao. "Dietary Nitrite in Nitric Oxide Biology: A Redox Interplay with Implications for Pathophysiology and Therapeutics". Current Drug Targets 12 9 (2011): 1351-1363. http://dx.doi.org/10.2174/138945011796150334.
    10.2174/138945011796150334
  25. Rocha, Bárbara S.; Gago, Bruno; Barbosa, Rui M.; Laranjinha, João. "Diffusion of nitric oxide through the gastric wall upon reduction of nitrite by red wine: Physiological impact". Nitric Oxide 22 3 (2010): 235-241. http://dx.doi.org/10.1016/j.niox.2010.01.003.
    10.1016/j.niox.2010.01.003
  26. Rocha, Bárbara S.; Gago, Bruno; Barbosa, Rui M.; Laranjinha, João. "Dietary polyphenols generate nitric oxide from nitrite in the stomach and induce smooth muscle relaxation". Toxicology 265 1-2 (2009): 41-48. http://dx.doi.org/10.1016/j.tox.2009.09.008.
    10.1016/j.tox.2009.09.008
  27. Gago, Bruno; Nyström, Thomas; Cavaleiro, Carlos; Rocha, Bárbara S.; Barbosa, Rui M.; Laranjinha, João; Lundberg, Jon O.. "The potent vasodilator ethyl nitrite is formed upon reaction of nitrite and ethanol under gastric conditions". Free Radical Biology and Medicine 45 4 (2008): 404-412. http://dx.doi.org/10.1016/j.freeradbiomed.2008.04.027.
    10.1016/j.freeradbiomed.2008.04.027
Capítulo de livro
  1. Rocha, Barbara S; Rocha, Nelson Pacheco; Gago, Bruno. "Nanoparticles for Brain Drug Delivery: Translational Challenges". In Nanoparticles for Brain Drug Delivery, 453-463. New York, Estados Unidos: Taylor & Francis Group, 2021.
    Publicado
  2. Ledo, A.; Rocha, B. S.; Laranjinha, J.. "Bioactive Lipids and the Gut-Brain Axis: Diet as a Modulator of Bioactivity and Diversity of Lipids in the Brain". In Advances in Experimental Medicine and Biology, 147-168. Springer International Publishing, 2019.
    10.1007/978-3-030-11488-6_10
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2022/07/14 Dietary nitrate prevents the loss of intestinal claudin-5 induced by broad-spectrum antibiotics but has limited impact on gut microbiome diversity. IUBMB-FEBS-PABMB, The Biochemistry Global Summit
2022/06/18 Can dietary nitrate fuel gut microbiota metabolism? Minding the gap between redox signalling and inter-kingdom communication The Future of Redox Biology
Society for Free Radical Research Europe; Oxygen Club of California
2018/06/07 Dietary nitrate modulates gut microbiota profile and prevents the activation of mucosal inflammatory pathways induced by broad-spectrum antibiotics. 19th Biennial Meeting of the Society for Free Radical Research International
(Lisbon, Portugal)
2017/06/08 Interacção entre o microbiota intestinal e o hospedeiro durante antibioterapia: novas vias de sinalização com impacto na homeostasia gastrointestinal. Semana Digestiva 2017, Congresso da Sociedade Portuguesa de Gastrenterologia.
Sociedade Portuguesa de Gastrenterologia. (albufeira, Portugal)
2015/09/02 Gut microbiome is rescued by dietary nitrate during dysbiosis: the impact on epithelial fence function and inflammatory pathways during antibiotic therapy. European Meeting of the Society for Free Radical Research.
(Stuttgart, Alemanha)
2014/11/07 The microbiota-gut-brain-axis: from kitchen to bedside. Cérebro e suas (Dis)funções. Congresso do Núcleo de Estudantes de Farmácia.
(Coimbra, Portugal)
2014/06/05 A shortcut to comprehensive health benefits of dietary polyphenols: the nitrate-nitrite-nitric oxide pathway. 8th World Congress on Polyphenols Applications.
(lisboa, Portugal)
2014/05/16 The nitrate-nitrite-nitric oxide pathway and gut microbiota on gastric protein nitration: implications for peptic ulcer disease. Center for Neuroscience and Cell Biology Seminars - Summer Series.
(Coimbra, Portugal)
2013/04/18 Pepsin is nitrated in the stomach acquiring anti-ulcerogenic activity: a novel nitrating pathway involving dietary nitrite, gut microbiota and gastric proteins. 47th Annual Scientific Meeting of the European Society for Clinical Investigation.
(Albufeira, Portugal)
2012/09/08 Pepsin is nitrated in the stomach acquiring anti-ulcerogenic activity: a novel nitrating pathway involving dietary nitrite, gut microbiota and gastric proteins. 16th Biennial Meeting of the Society for Free Radical Research International.
(London, Reino Unido)
2011/09/08 Dietary nitrite is a nitrating agent in the stomach and generates anti-ulcerogenic compounds in vivo. European Meeting of the Society for Free Radical Research.
(Istanbul, Turquia)
2011/07/12 Pepsinogen is nitrated in the stomach in vivo: a dual function for dietary nitrate with functional and physiological consequences. Physiology 2011 – Annual Meeting of the Physiological Society.
(Oxford, Reino Unido)
2011/06/16 Pepsinogen is nitrated in the stomach in vivo: modulation by NSAIDs, oral bacteria and salivary nitrite. 4th Symposium on Nutrition, Oxygen Biology and Medicine
(Paris, França)
2010/12/20 Nitration of pepsinogen in vivo under acute gastric inflammation: dietary nitrate as a key modulator of nitration in the stomach. Annual Meeting of the Center for Neuroscience and Cell Biology.
(Coimbra, Portugal)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2021 - Atual Helicobacter pylori eradication therapy in Portugal: prospective, randomised, blind and multi centre trial on the efficacy of quadruple therapies and their clinical impact and immunological, oral and gut microbiota changes.
Coorientador
2020 - Atual Impact of exocrine pancreatic insufficiency associated with acute pancreatitis and pancreatic enzyme replacement therapy on gut microbiota, immunological changes and quality of life: longitudinal prospective study and randomised double blind placebo control clinical trial.
Coorientador
2024/01 - 2024/07 The modulatory effect of dietary nitrate on the oral microbiota and the expression of inflammatory markers along the gut
Orientador
 Master in Clinical Analysis (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2023/04 - 2023/07 The impact of antiseptic mouthwash in the composition and functional capacity of the oral microbiota
Orientador
 Master in Pharmaceutical Sciences (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2023/11/07 - Atual Second Workshop on the Biochemistry of Ageing (2023/11/07)
Oficina (workshop) (Membro da Comissão Organizadora)
 Sociedade Portuguesa de Bioquímica, Portugal
2021/03/30 - Atual First Workshop on the Biochemistry of Ageing (2021/03/30)
Oficina (workshop)
 Sociedade Portuguesa de Bioquímica, Portugal
2023/05/22 - 2023/05/25 Organising committee (co-chair) of the FEBS Redox Medicine: from cellular signalling to systems physiology and therapeutic targets (FEBS workshop) (2023/05/22 - 2023/05/25)
Oficina (workshop) (Coorganizador)
2019/06/19 - 2019/06/21 Organisation of the symposium "The microbiota-gut-brain axis: a journey from dietary nitrate to nitric oxide via inorganic nitrite" at the 2019 annual Meeting of the Society for Free Radical Research (SFRRE). Ferrara, Italy. (2019/06/19 - 2019/06/21)
Simpósio (Coorganizador)
2018/06/04 - 2018/06/07 Organisation of the “Early Career Symposium” at the 19th Meeting of the Society for Free Radical research International (2018/06/04 - 2018/06/07)
Seminário (Coorganizador)
2015/09/01 - 2015/09/04 Organisation of the "SFRRE/SFN Early Carrer Investigators Forum” at the Annual meeting of the Society for Free Radical Research, Stuttgart, Germany (2015/09/01 - 2015/09/04)
Simpósio (Coorganizador)

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2022/10/28 - Atual Lecture: "Microorganisms in Human Health: how the intestinal microbiota determines the genesis and evolution of Inflammatory Bowel Disease". Initiative organised for the general public and patients with Inflammatory Bowel Disease, as well as scientific and health sectors
Conferência
 One Health Conference. Get to know your gut
Ordem dos Farmaceuticos, Portugal
2022/06/17 - 2022/06/19 Can dietary nitrate fuel gut microbiota metabolism? Minding the gap between redox signalling and inter-kingdom communication. The Future of Redox Biology, 17-19 Junho 2022. Siena, Itália
Congresso
 The Future of Redox Biology
Society for Free Radical Biology and Medicine - Europe, Reino Unido

The Oxygen Club of California, Estados Unidos
2021/10/14 - 2021/10/16 Inorganic nitrate prevents the loss of intestinal claudin-5 induced by broad-spectrum antibiotics but has a mild impact on gut microbiome diversity: may nitrate be fueling bacterial metabolism? (poster presentation)
Conferência
 XXI SPB National Congress of Biochemistry 2020
Sociedade Portuguesa de Bioquímica, Portugal
2016/07/29 - 2016/07/31 Dietary nitrate modulates gut microbiome profile and prevents the activation of mucosal inflammatory pathways induced by broad-spectrum antibiotics.
Congresso
 Physiology 2016 - Annual Meeting of the Physiological Society
2014/12/17 - 2014/12/20 The nitrate-nitrite-nitric oxide pathway: reshaping gut microbiota and mucosal homeostasis under dysbiosis.
Congresso
 XVIII Congress of the Portuguese Biochemical Society
2014/11/19 - 2014/11/23 Dietary nitrate reshapes gut microbiota and attenuates gastric mucosal inflammation during dysbiosis.
Congresso
 21st Annual Meeting of the Society for Free Radical Biology and Medicine

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2023/01/18 MicroSpA: a Gut Microbiota and Axial Spondyloarthritis: The Impact on Anti-Tnf Therapy
Arguente principal
 Diana Rodrigues (Mestrado)
2022/12/20 NO2PROBE: Application of a new nitrite point-of-care test in biomedicine
Arguente principal
 Sara Gaspar (Mestrado)
2022/09/30 Dynamic changes of aerobic brain oxidative metabolism revealed by lactate and the redox modulation by nitrite
Arguente
 Candida Dias (Doutoramento)
2018 Staphylococcus aureus meticilina resistente: gene mecC e susceptibilidade à vancomicina
Arguente
 Raquel Catarina Saraiva Diaz (Doutoramento)
Universidade de Aveiro, Portugal
2016 Uma abordagem epigenética à determinação da idade de amostras biológicas: potenciais aplicações forenses
Arguente principal
 Sílvia Vale (Mestrado)
Universidade de Aveiro, Portugal
2014 Fingolimod a real world experience
Arguente principal
 Joaquim Fonseca (Mestrado)
Universidade de Aveiro, Portugal

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2020 - Atual Frontiers in Ageing - Molecular Aspects of Ageing Frontiers
2023/05 - 2024/06 FEBS Letters FEBS Press

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2019 - 2019 Evaluation and selection of abstracts for oral communication at the 26th meeting of the Society for Free radical Biology and Medicine (SFRBM), USA
Avaliador
2018 - 2018 Evaluation and selection of abstracts for oral presentation at the 25th meeting of the Society for Free radical Biology and Medicine (SFRBM), Chicago, USA
Avaliador

Entrevista (jornal / revista)

Descrição da atividade Jornal / Forum
2022/05/25 Interview on "Strategies to improve the health of our gut microbiota" Jornal Diário As Beiras
2022/05 interview on the modulation of the intestinal microbiota through the consumption of nitrate-rich vegetables and its implications for the prevention of side effects associated with antibiotics consumption Diário As Beiras
2013 Interview on the prevention of gastric ulcers through the consumption of nitrate-rich vegetables Jornal Público

Membro de associação

Nome da associação Tipo de participação
2023/01 - Atual Portuguese Biochemical Society Treasurer
2018 - Atual Ordem dos Médicos
2015 - Atual Society for Free radical Research Europe
2010 - Atual Sociedade Portuguesa de Bioquímica Part of direction board since 2018
2010 - Atual The Physiological Society
2019/01 - 2022/12 Portuguese Biochemical Society Adjunct secretary
2009 - 2013 Society for Free Radical Biology and Medicine

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2021 - 2022 Organising committee of the IUBMB-FEBS-PABMB Young Scientists Forum, Portugal, 2022 The IUBMB-FEBS-PABMB Young Scientists Forum will bring together 120 selected young researchers in biochemistry and molecular biology, who will be supported to attend by grants from FEBS, IUBMB and PABMB and will precede The Biochemistry Global Summit in Lisbon (July 2022)

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2023/10/20 - Atual The oral N-metabolism and its correlation with periodontal disease and hypertension: a cross sectional study (main arguer of the PhD probationary year report) Instituto Universitário Egas Moniz Escola Superior de Saúde Egas Moniz, Portugal
2015 - Atual Reviewer of scientific manuscripts in several peer-reviewed journals, such as The Journal of Physiology, International Journal of Cardiology, Free Radical Biology and Medicine, Nitric Oxide Biology & Chemistry, Free Radical Research, Journal of Infectiology and International Journal of Food Science
Distinções

Prémio

2022 The Future of Redox Biology
The Oxygen Club of California, Estados Unidos
2016 Travel award
The Physiological Society, Reino Unido
2014 Best Poster presentation
2014 Travel award
The Physiological Society, Reino Unido
2011 Young investigator award
2011 Travel award
The Physiological Society, Reino Unido
2010 Best oral presentation
Federation of the European Biochemical Societies, Portugal
2010 Travel award
Federation of the European Biochemical Societies, Portugal