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José Alberto Martins. Completed the degree in Biochemistry in 1988 by University of Coimbra, Faculdade de Ciências e Tecnologia and Doctor of Philosophy, PhD in Chemistry, in 2000 by University of Warwick. Published 51 articles in journals. Has 1 section(s) of books. Has 2 patent(s) registered. Supervised 3 PhD thesis and co-supervised 4. Supervised 5 MSc dissertation(s) and co-supervised 3. Participates and/or participated as Co-Principal Investigator (Co-PI) in 1 project(s) and Researcher in 7 project(s). Works in the area(s) of Organic, Bioorganic and Bioinorganic Chemistry and Medicinal Chemistry. In his curriculum Ciência Vitae the most frequent terms in the context of scientific and technological output are: "metal chelators"; "metal complexes"; "medical imaging"; "MRI, PET, SPECT"; "multimodality"; "Contrast Agents"; "relaxometry"; "nanoparticles"; "nanostructures"; "SPION"; "magnetogels"; "hyperthermia"; "peptide synthesis"; "self-assembly"; "self-assembled peptide hydrogels"; "drug-delivery"; "theranostics" .
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Identificação

Identificação pessoal

Nome completo
José Alberto Martins

Nomes de citação

  • Martins, José
  • Martins J. A.
  • Martins, J.

Identificadores de autor

Ciência ID
EC10-E0D8-22C1
ORCID iD
0000-0001-9323-3978

Endereços de correio eletrónico

  • jmartins@quimica.uminho.pt (Profissional)

Telefones

Telefone
  • 253604385 (Profissional)

Moradas

  • Departamento de Química, Universidade do Minho, Campus de Gualtar , 4710-057, Gualtar, Braga, Braga, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Química Médica
  • Ciências Exatas - Química - Química Orgânica
  • Ciências Exatas - Química - Química Inorgânica
  • Ciências Naturais - Ciências Biológicas - Bioquímica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Francês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B2)
Formação
Grau Classificação
1996/09/01 - 2000/09/03
Concluído
 PhD Chemistry (Doctor of Philosophy)
Especialização em Organic and Bioorganic Chemistry
University of Warwick, Reino Unido
"Solution and Solid-Phase Biotransformations" (TESE/DISSERTAÇÃO)
 Aproved
1984/09/01 - 1988/07/30
Concluído
 Bioquímica (Licenciatura)
Especialização em NA
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
 BOM
Percurso profissional

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2000/06/01 - 2020 Professor Auxiliar (Docente Universitário) Universidade do Minho, Portugal
Universidade do Minho Centro de Química, Portugal
1996 - 2000 Assistente (Docente Universitário) Universidade do Minho, Portugal
Universidade do Minho Departamento de Química, Portugal
Projetos

Projeto

Designação Financiadores
2021/01/02 - 2023/06/30 New imaging biomarkers in the assessment of chronic total coronary occlusion - BioImage2CTO – 39698
BioImage2CTO – 39698
Investigador
Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal

Universidade de Coimbra Centro de Imagem Biomédica e Investigação Translacional, Portugal

Universidade de Coimbra, Portugal

Universidade do Minho Centro de Química, Portugal
Agência Nacional de Inovação SA
Em curso
2018/09/15 - 2021/09/14 Self-assembled minimalist peptide hydrogels inspired by mussel adhesive proteins for biomedical applications
PTDC/QUI-QOR/29015/2017
Co-Investigador Responsável (Co-IR)
Universidade do Minho, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2013/06/03 - 2015/09/30 Concise and highly stereoselective strategy in the synthesis of aza-sugars. Theoretical studies and biological evaluation of Products
PTDC/QEQ-MED/1671/2012
Investigador
Universidade do Minho, Portugal

Universidade do Minho Centro de Química, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2012/03/01 - 2015/08/31 Influence of Salt Additives on Protein Extraction in Aqueous Polymer/Salt Two-Phase Systems
PTDC/EQU-FTT/120332/2010
Investigador
Universidade do Minho, Portugal

Instituto de Biotecnologia e Bioengenharia, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2009/01/05 - 2012/07/03 Common strategy for the synthesis of azasugars and modified nucleotides. Biological evaluation.
PTDC/QUI/67407/2006
Investigador
Universidade do Minho, Portugal

Universidade do Minho Centro de Química, Portugal

Universidade do Algarve, Portugal

Universidade do Porto Faculdade de Ciências, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2008/01/01 - 2011/12/31 Targeted Nanostructures for Multimodal Molecular Medical Imaging
PTDC/QUI/70063/2006
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade do Minho, Portugal

Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2005/06/01 - 2008/05/31 The Influence of the Chemical Structure of Polymers on Proteins Partition
POCI/EQU/60720/2004
Investigador
Universidade do Porto Faculdade de Engenharia, Portugal

Universidade do Porto Laboratório de Processos de Separação e Reacção Laboratório de Catálise e Materiais, Portugal

Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2003/10/01 - 2007 Targeted Contrast Agents for Magnetic Resonance Imaging (MRI) and Nuclear Scintigraphy (TARCAS)
info:eu-repo/grantAgreement/FCT/POCI/47005/PT
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Universidade do Algarve Faculdade de Ciências e Tecnologia
Concluído
Produções

Publicações

Artigo em conferência
  1. Peter J. Jervis; Inês Baptista; Luciana Martins; David M. Pereira; José A. Martins; Paula M. T. Ferreira. "Hydrogels and Nanostructures Formed from Ciprofloxacin–Peptide Conjugates". 2023.
    10.3390/IOCN2023-14493
  2. André Carvalho; Paula M. T. Ferreira; José A. Martins. "New 2,6-Bis(5-phenyloxazolyl)pyridine Ligands for Luminescent LnIII Complexes". 2022.
    10.3390/ecsoc-26-13714
  3. Carolina Beltrán; Peter Cifuentes; Juliana Castellanos; Paula Ruiz; José Ellis; David Arango; Carolina Muñoz-Camargo; Luis H. Reyes; Juan C. Cruz. "Delivery of Linear Gene-Editing Systems by Cell-Penetrating Magnetite Vehicles: Synthesis, Characterization and Preliminary In Vitro Testing". 2020.
    10.3390/IOCN2020-07927
Artigo em revista
  1. Carlos B. P. Oliveira; André Carvalho; Renato B. Pereira; David M. Pereira; Loic Hilliou; Peter J. Jervis; José A. Martins; Paula M. T. Ferreira. "New Supramolecular Hydrogels Based on Diastereomeric Dehydrotripeptide Mixtures for Potential Drug Delivery Applications". Gels (2024): https://doi.org/10.3390/gels10100629.
    10.3390/gels10100629
  2. Alexandra Machado; Miguel Gama; José Alberto Martins. "Development of a dextrin–vitamin D3 micelle nanocarrier for the antimicrobial peptide LLKKK18 as a potential therapeutic agent for bone infections". Journal of Materials Chemistry B (2024): https://doi.org/10.1039/D4TB00903G.
    10.1039/D4TB00903G
  3. Vilaça, Helena; Carvalho, André; Castro, Tarsila; Castanheira, Elisabete M. S.; Hilliou, Loic; Hamley, Ian; Melle-Franco, Manuel; Ferreira, Paula M. T.; Martins J. A.. Autor correspondente: Martins J. A.. "Unveiling the Role of Capping Groups in Naphthalene N-Capped Dehydrodipeptide Hydrogels". Gels 9 6 (2023): 464. http://dx.doi.org/10.3390/gels9060464.
    Acesso aberto • 10.3390/gels9060464
  4. Correia da Silva, Daniela; Jervis, Peter J.; Martins J. A.; Valentão, Patrícia; Ferreira, Paula M.T.; Pereira, David M.. Autor correspondente: Pereira, David M.. "Fisetin derivatives exhibit enhanced anti-inflammatory activity and modulation of endoplasmic reticulum stress". International Immunopharmacology 119 (2023): 110178. http://dx.doi.org/10.1016/j.intimp.2023.110178.
    10.1016/j.intimp.2023.110178
  5. Oliveira, Carlos B. P.; Gomes, Valéria; Ferreira, Paula M. T.; Martins, José A.; Jervis, Peter J.. "Peptide-Based Supramolecular Hydrogels as Drug Delivery Agents: Recent Advances". Gels 8 11 (2022): 706. http://dx.doi.org/10.3390/gels8110706.
    10.3390/gels8110706
  6. Carlos B. P. Oliveira; Renato B. Pereira; David M. Pereira; Loic Hilliou; Tarsila G. Castro; José A. Martins; Peter J. Jervis; Paula M. T. Ferreira. "Aryl-Capped Lysine-Dehydroamino Acid Dipeptide Supergelators as Potential Drug Release Systems". International Journal of Molecular Sciences 23 19 (2022): 11811. https://doi.org/10.3390/ijms231911811.
    Acesso aberto • Publicado • 10.3390/ijms231911811
  7. Oliveira, Carlos B. P.; Veloso, Sérgio R. S.; Castanheira, Elisabete M. S.; Figueiredo, Pedro R.; Carvalho, Alexandra T. P.; Hilliou, Loic; Pereira, Renato B.; et al. "An injectable, naproxen-conjugated, supramolecular hydrogel with ultra-low critical gelation concentration—prepared from a known folate receptor ligand". Soft Matter 18 20 (2022): 3955-3966. http://dx.doi.org/10.1039/d2sm00121g.
    10.1039/d2sm00121g
  8. Nuno R. da Silva; Paula Jorge; José A. Martins; José A. Teixeira; João C. Marcos. "Initial Screening of Poly(ethylene glycol) Amino Ligands for Affinity Purification of Plasmid DNA in Aqueous Two-Phase Systems". Life 11 11 (2021): 1138. https://doi.org/10.3390/life11111138.
    10.3390/life11111138
  9. Zoltán Garda; Tamara Kócs; István Bányai; José A. Martins; Ferenc Krisztián Kálmán; Imre Tóth; Carlos F. G. C. Geraldes; Gyula Tircsó. "Complexes of Bifunctional DO3A-N-(a-amino)propinate Ligands with Mg(II), Ca(II), Cu(II), Zn(II), and Lanthanide(III) Ions: Thermodynamic Stability, Formation and Dissociation Kinetics, and Solution Dynamic NMR Studies". Molecules 26 16 (2021): 4956. https://doi.org/10.3390/molecules26164956.
    10.3390/molecules26164956
  10. Carolina Amorim; Sérgio R. S. Veloso; Elisabete M. S. Castanheira; Loic Hilliou; Renato B. Pereira; David M. Pereira; José A. Martins; Peter J. Jervis; Paula M. T. Ferreira. "Bolaamphiphilic Bis-Dehydropeptide Hydrogels as Potential Drug Release Systems". Gels 7 2 (2021): 52. https://doi.org/10.3390/gels7020052.
    10.3390/gels7020052
  11. Jervis, Peter J.; Hilliou, Loic; Pereira, Renato B.; Pereira, David M.; Martins, José A.; Ferreira, Paula M. T.. "Evaluation of a Model Photo-Caged Dehydropeptide as a Stimuli-Responsive Supramolecular Hydrogel". Nanomaterials 11 3 (2021): 704. http://dx.doi.org/10.3390/nano11030704.
    10.3390/nano11030704
  12. Peter J. Jervis; Carolina Amorim; Teresa Pereira; José A. Martins; Paula M. T. Ferreira. "Dehydropeptide Supramolecular Hydrogels and Nanostructures as Potential Peptidomimetic Biomedical Materials". International Journal of Molecular Sciences 22 5 (2021): 2528. https://doi.org/10.3390/ijms22052528.
    10.3390/ijms22052528
  13. Veloso, Sérgio R.S.; Jervis, Peter J.; Silva, Joana F.G.; Hilliou, Loic; Moura, C.; Pereira, David M.; Coutinho, Paulo J.G.; et al. "Supramolecular ultra-short carboxybenzyl-protected dehydropeptide-based hydrogels for drug delivery". Materials Science and Engineering: C 122 (2021): 111869. http://dx.doi.org/10.1016/j.msec.2021.111869.
    10.1016/j.msec.2021.111869
  14. Sérgio R. S. Veloso; Joana F. G. Silva; Loic Hilliou; Cacilda Moura; Paulo J. G. Coutinho; José A. Martins; Martín Testa-Anta; et al. "Impact of Citrate and Lipid-Functionalized Magnetic Nanoparticles in Dehydropeptide Supramolecular Magnetogels: Properties, Design and Drug Release". Nanomaterials 11 1 (2020): 16. https://doi.org/10.3390/nano11010016.
    10.3390/nano11010016
  15. Sérgio R. S. Veloso; Raquel G. D. Andrade; Beatriz C. Ribeiro; André V. F. Fernandes; A. Rita O. Rodrigues; J. A. Martins; Paula M. T. Ferreira; Paulo J. G. Coutinho; Elisabete M. S. Castanheira. "Magnetoliposomes Incorporated in Peptide-Based Hydrogels: Towards Development of Magnetolipogels". Nanomaterials 10 9 (2020): 1702. https://doi.org/10.3390/nano10091702.
    Publicado • 10.3390/nano10091702
  16. Moreira, Rute; Jervis, Peter J.; Carvalho, André; Ferreira, Paula M. T.; Martins, José A.; Valentão, Patrícia; Andrade, Paula B.; et al. "Biological Evaluation of Naproxen–Dehydrodipeptide Conjugates with Self-Hydrogelation Capacity as Dual LOX/COX Inhibitors". Pharmaceutics 12 2 (2020): 122. http://dx.doi.org/10.3390/pharmaceutics12020122.
    Acesso aberto • Publicado • 10.3390/pharmaceutics12020122
  17. Sérgio R. S. Veloso; J. A. Martins; Loic Hilliou; C. O. Amorim; V. S. Amaral; B. G. Almeida; Peter J. Jervis; et al. "Dehydropeptide-based plasmonic magnetogels: a supramolecular composite nanosystem for multimodal cancer therapy". Journal of Materials Chemistry B 8 (2020): 45-64. https://doi.org/10.1039/C9TB01900F.
    Publicado • 10.1039/C9TB01900F
  18. Jervis, Peter J.; Amorim, Carolina; Pereira, Teresa; Martins, José A.; Ferreira, Paula M. T.. "Exploring the properties and potential biomedical applications of NSAID-capped peptide hydrogels". Soft Matter 16 44 (2020): 10001-10012. http://dx.doi.org/10.1039/d0sm01198c.
    10.1039/D0SM01198C
  19. André Carvalho; Juan Gallo; David Pereira; Patrícia Valentão; Paula Andrade; Loic Hilliou; Paula Ferreira; Manuel Bañobre-López; José Martins. "Magnetic Dehydrodipeptide-Based Self-Assembled Hydrogels for Theragnostic Applications". Nanomaterials 9 4 (2019): 541. https://doi.org/10.3390/nano9040541.
    Publicado • 10.3390/nano9040541
  20. Sérgio R. S. Veloso; Carlos A. B. Magalhães; Ana Rita O. Rodrigues; H. Vilaça; Maria-João R. P. Queiroz; J. A. Martins; Paulo J. G. Coutinho; Paula M. T. Ferreira; Elisabete M. S. Castanheira. "Novel dehydropeptide-based magnetogels containing manganese ferrite nanoparticles as antitumor drug nanocarriers". Physical Chemistry Chemical Physics 21 (2019): 10377. https://doi.org/10.1039/C9CP00352E.
    Publicado • 10.1039/C9CP00352E
  21. Veloso, Sérgio; Ferreira, Paula; Martins, José; Coutinho, Paulo; Castanheira, E. M. S.. "Magnetogels: Prospects and Main Challenges in Biomedical Applications". Pharmaceutics 10 3 (2018): 145. http://dx.doi.org/10.3390/pharmaceutics10030145.
    Publicado • 10.3390/pharmaceutics10030145
  22. Helena Vilaça; Tarsila Castro; Fernando M. G. Costa; Manuel Melle-Franco; Loic Hilliou; Ian W. Hamley; Elisabete M. S. Castanheira; José A. Martins; Paula M. T. Ferreira. "Self-assembled RGD dehydropeptide hydrogels for drug delivery applications". Journal of Materials Chemistry B 5 43 (2017): 8607-8617. https://doi.org/10.1039/C7TB01883E.
    10.1039/C7TB01883E
  23. Mao, B. Y.; Calatayud, D. G.; Mirabello, V.; Kuganathan, N.; Ge, H. B.; Jacobs, R. M. J.; Shepherd, A. M.; et al. "Fluorescence-Lifetime Imaging and Super-Resolution Microscopies Shed Light on the Directed- and Self-Assembly of Functional Porphyrins onto Carbon Nanotubes and Flat Surfaces". Chemistry-a European Journal 23 41 (2017): 9772-9789. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000405923800014&KeyUID=WOS:000405923800014.
    Publicado • 10.1002/chem.201605232
  24. Marslin, Gregory; Sarmento, Bruno; Franklin, Gregory; Martins, José; Silva, Carlos; Gomes, Andreia; Sárria, Marisa; et al. "Curcumin Encapsulated into Methoxy Poly(Ethylene Glycol) Poly(e-Caprolactone) Nanoparticles Increases Cellular Uptake and Neuroprotective Effect in Glioma Cells". Planta Medica 83 05 (2016): 434-444. http://dx.doi.org/10.1055/s-0042-112030.
    Publicado • 10.1055/s-0042-112030
  25. Mao, Boyang; Calatayud, David G.; Mirabello, Vincenzo; Hodges, Benjamin J.; Ribeiro Martins, Jose Alberto; Botchway, Stanley W.; Mitchels, John M.; Pascu, Sofia I.. "Interactions between an Aryl Thioacetate-Functionalized Zn(II) Porphyrin and Graphene Oxide". Advanced Functional Materials 26 5 (2016): 687-697. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000369969100004&KeyUID=WOS:000369969100004.
    Publicado • 10.1002/adfm.201504147
  26. Vilaca, Helena; Hortelao, Ana C. L.; Castanheira, Elisabete M. S.; Queiroz, Maria-Joao R. P.; Hilliou, Loic; Hamley, Ian W.; Martins, Jose A.; Ferreira, Paula M. T.. "Dehydrodipeptide Hydrogelators Containing Naproxen N-Capped Tryptophan: Self-Assembly, Hydrogel Characterization, and Evaluation as Potential Drug Nanocarriers". Biomacromolecules 16 11 (2015): 3562-3573. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000364614300016&KeyUID=WOS:000364614300016.
    Publicado • 10.1021/acs.biomac.5b01006
  27. Martins, José; Vilaca, H.; Pereira, G.; Castro, T. G.; Hermenegildo, B. F.; Shi, J.; Faria, T. Q.; et al. "New self-assembled supramolecular hydrogels based on dehydropeptides". Journal of Materials Chemistry B 3 30 (2015): 6355-6367. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000358351400023&KeyUID=WOS:000358351400023.
    Publicado • 10.1039/C5TB00501A
  28. Goncalves, C.; Silva, J. P.; Antunes, I. F.; Ferreira, M. F. M.; Martins, J. A.; Geraldes, C. F. G. C.; Lalatonne, Y.; et al. "Dextrin-Based Nanomagnetogel: In Vivo Biodistribution and Stability". Bioconjugate Chemistry 26 4 (2015): 699-706. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000353177300011&KeyUID=WOS:000353177300011.
    Publicado • 10.1021/acs.bioconjchem.5b00024
  29. Ferreira, Miguel F.; Goncalves, Janaina; Mousavi, Bibimaryam; Prata, Maria I. M.; Rodrigues, Sergio P. J.; Calle, Daniel; Lopez-Larrubia, Pilar; et al. "Gold nanoparticles functionalised with fast water exchanging Gd3+ chelates: linker effects on the relaxivity". Dalton Transactions 44 9 (2014): 4016-4031. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000349993400017&KeyUID=WOS:000349993400017.
    Publicado • 10.1039/c4dt03210a
  30. Ferreira, Miguel F.; Pereira, Goretti; Andre, Joao P.; Prata, M. I. M.; Ferreira, Paula M. T.; Martins, Jose A.; Geraldes, Carlos F. G. C.. "Ga[NO2A-N-(alpha-amino)propionate] chelates: synthesis and evaluation as potential tracers for Ga-68 PET". Dalton Transactions 43 21 (2014): 8037-8047. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000335926800043&KeyUID=WOS:000335926800043.
    Publicado • 10.1039/c4dt00386a
  31. Gregory, M.; Sarmento, B.; Duarte, S.; Martins, J. A.; Silva, C.; Coutinho, O.; Dias, A.. "Curcumin loaded MPEG-PCL di-block copolymer nanoparticles protect glioma cells from oxidative damage". Planta Medica 80 16 (2014): 1468-1468. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000345550400359&KeyUID=WOS:000345550400359.
  32. Antunes, I. Farinha; Goncalves, C.; Silva, J. P.; Ferreira, M. F. A.; Martins, J. A.; Geraldes, C. F. G. C.; Lalatonne, Y.; et al. "In vivo dextrin nanomagnetogel performance as dual imaging bioprobe". European Journal of Nuclear Medicine and Molecular Imaging 41 (2014): S414-S414. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000348841901192&KeyUID=WOS:000348841901192.
  33. Ferreira, M. F.; Pereira, G.; Martins, A. F.; Martins, C. I. O.; Prata, M. I. M.; Petoud, S.; Toth, E.; et al. "Ln[DO3A-N-alpha-(pyrenebutanamido)propionate] complexes: optimized relaxivity and NIR optical properties". Dalton Transactions 43 8 (2013): 3162-3173. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000330785100019&KeyUID=WOS:000330785100019.
    Publicado • 10.1039/c3dt52958d
  34. Gonçalves, C.; Lalatonne, Y.; Melro, L.; Badino, G.; Ferreira, M.F.M.; David, L.; Geraldes, C.F.G.C.; et al. "New dextrin nanomagnetogels as contrast agents for magnetic resonance imaging". Journal of Materials Chemistry B 1 42 (2013): 5853-5864. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885464908&partnerID=MN8TOARS.
    Publicado • 10.1039/c3tb21063d
  35. Barros, S.C.; Louro, R.O.; Micaêlo, N.M.; Martins, J.A.; Marcos, J.C.; Cavaco-Paulo, A.. "NMR and molecular modelling studies on elastase inhibitor-peptides for wound management". Reactive and Functional Polymers 73 10 (2013): 1357-1365. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885376832&partnerID=MN8TOARS.
    Publicado • 10.1016/j.reactfunctpolym.2013.02.011
  36. Ferreira, M.F.; Martins, A.F.; Martins, C.I.O.; Ferreira, P.M.; Tóth, E.; Rodrigues, T.B.; Calle, D.; et al. "Amide conjugates of the DO3A-N-(a-amino)propionate ligand: Leads for stable, high relaxivity contrast agents for MRI?". Contrast Media and Molecular Imaging 8 1 (2013): 40-49. http://www.scopus.com/inward/record.url?eid=2-s2.0-84868094442&partnerID=MN8TOARS.
    Publicado • 10.1002/cmmi.1492
  37. Barros, Sandra Cerqueira; Martins, José Alberto; Marcos, João Carlos; Cavaco-Paulo, Artur; Barros, S.C.; Martins, J.A.; Marcos, J.C.; Cavaco-Paulo, A.. "Influence of secretory leukocyte protease inhibitor-based peptides on elastase activity and their incorporation in hyaluronic acid hydrogels for chronic wound therapy". Biopolymers 98 6 (2012): 576-590. http://dx.doi.org/10.1002/bip.22166.
    Publicado • 10.1002/bip.22166
  38. Pereira, G.; Ferreira, M.F.; Castanheira, E.M.S.; Martins, J.A.; Ferreira, P.M.T.. "Synthesis of 2,6-bis(oxazolyl)pyridine ligands for luminescent Ln III complexes". European Journal of Organic Chemistry 21 (2012): 3905-3910. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863952052&partnerID=MN8TOARS.
    Publicado • 10.1002/ejoc.201200177
  39. Ferreira, M.F.; Mousavi, B.; Ferreira, P.M.; Martins, C.I.O.; Helm, L.; Martins, J.A.; Geraldes, C.F.G.C.. "Gold nanoparticles functionalised with stable, fast water exchanging Gd 3+ chelates as high relaxivity contrast agents for MRI". Dalton Transactions 41 18 (2012): 5472-5475. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859796835&partnerID=MN8TOARS.
    Publicado • 10.1039/c2dt30388d
  40. Barros, S.C.; Martins, J.A.; Marcos, J.C.; Cavaco-Paulo, A.. "Characterization of potential elastase inhibitor-peptides regulated by a molecular switch for wound dressings applications". Enzyme and Microbial Technology 50 2 (2012): 107-114. http://www.scopus.com/inward/record.url?eid=2-s2.0-84855432805&partnerID=MN8TOARS.
    Publicado • 10.1016/j.enzmictec.2011.10.006
  41. Silvério, S.C.; Ferreira, L.A.; Martins, J.A.; Marcos, J.C.; Macedo, E.A.; Teixeira, J.A.. "Lysozyme and bovine serum albumin partitioning in polyethylene glycol-phenylalanine conjugate polymer/salt aqueous two-phase systems". Fluid Phase Equilibria 322-323 (2012): 19-25. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859959117&partnerID=MN8TOARS.
    Publicado • 10.1016/j.fluid.2012.03.003
  42. Alves, M.J.; Costa, F.T.; Duarte, V.C.M.; Fortes, A.G.; Martins, J.A.; Micaelo, N.M.. "Advances in the synthesis of homochiral (-)-1-azafagomine and (+)-5-epi-1-azafagomine. 1-N-phenyl carboxamide derivatives of both enantiomers of 1-azafagomine: Leads for the synthesis of active a-glycosidase inhibitors.". Journal of Organic Chemistry 76 23 (2011): 9584-9592. http://www.scopus.com/inward/record.url?eid=2-s2.0-82255170789&partnerID=MN8TOARS.
    Publicado • 10.1021/jo201486q
  43. Teixeira, J.M.C.; Dias, D.M.; Cañada, F.J.; Martins, J.A.; Andrá, J.P.; Jimánez-Barbero, J.; Geraldes, C.F.G.C.. "The interaction of La 3+ complexes of DOTA/DTPA glycoconjugates with the RCA 120 lectin: A saturation transfer difference NMR spectroscopic study". Journal of Biological Inorganic Chemistry 16 5 (2011): 725-734. http://www.scopus.com/inward/record.url?eid=2-s2.0-80051552449&partnerID=MN8TOARS.
    Publicado • 10.1007/s00775-011-0773-z
  44. Gonçalves, C.; Ferreira, M.F.M.; Santos, A.C.; Prata, M.I.M.; Geraldes, C.F.G.C.; Martins, J.A.; Gama, F.M.. "Studies on the biodistribution of dextrin nanoparticles". Nanotechnology 21 29 (2010): 295103. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954412360&partnerID=MN8TOARS.
    Publicado • 10.1088/0957-4484/21/29/295103
  45. Prata, M. M.; Goncalves, C.; Ferreira, M. M. F.; Santos, A. C.; Geraldes, C. F. G. C.; Martins, J. A.; Gama, F. M.. "In vivo evaluation of radiolabeled dextrin nanoparticles for drug delivery". European Journal of Nuclear Medicine and Molecular Imaging 37 (2010): S362-S362. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000283023801148&KeyUID=WOS:000283023801148.
  46. Torres, S.; Martins, J.A.; André, J.P.; Neves, M.; Santos, A.C.; Prata, M.I.M.; Geraldes, C.F.G.C.. "Radiolabeled 153Sm-chelates of glycoconjugates: Multivalence and topology effects on the targeting of the asialoglycoprotein receptor". Radiochimica Acta 95 6 (2009): 343-349. http://www.scopus.com/inward/record.url?eid=2-s2.0-34250738372&partnerID=MN8TOARS.
    10.1524/ract.2007.95.6.343
  47. Ferreira, M.F.; Martins, A.F.; Martins, J.A.; Ferreira, P.M.; Tóth, E.; Geraldes, C.F.G.C.. "Gd(DO3A-N-a-aminopropionate): A versatile and easily available synthon with optimized water exchange for the synthesis of high relaxivity, targeted MRI contrast agents". Chemical Communications 42 (2009): 6475-6477. http://www.scopus.com/inward/record.url?eid=2-s2.0-70350289656&partnerID=MN8TOARS.
    Publicado • 10.1039/b912201j
  48. Silvério, S.; Torres, S.; Martins, A.F.; Martins, J.A.; André, J.P.; Helm, L.; Prata, M.I.M.; Santos, A.C.; Geraldes, C.F.G.C.. "Lanthanide chelates of (bis)-hydroxymethyl-substituted DTTA with potential application as contrast agents in magnetic resonance imaging". Dalton Transactions 24 (2009): 4656-4670. http://www.scopus.com/inward/record.url?eid=2-s2.0-67749103643&partnerID=MN8TOARS.
    Publicado • 10.1039/b823402g
  49. Torres, S.; Prata, M.I.M.; Santos, A.C.; André, J.P.; Martins, J.A.; Helm, L.; Tóth, É.; et al. "Gd(III)-EPTPAC16, a new self-assembling potential liver MRI contrast agent: In vitro characterization and in vivo animal imaging studies". NMR in Biomedicine 21 4 (2008): 322-336. http://www.scopus.com/inward/record.url?eid=2-s2.0-44649111266&partnerID=MN8TOARS.
    Publicado • 10.1002/nbm.1194
  50. Torres, S.; Martins, J.A.; André, J.P.; Pereira, G.A.; Kiraly, R.; Brücher, E.; Helm, L.; Tóth, É.; Geraldes, C.F.G.C.. "H5EPTPACH2OH: Synthesis, relaxometric characterization and 1H NMR spectroscopic studies on the solution dynamics of its LnIII complexes". European Journal of Inorganic Chemistry 2007 35 (2007): 5489-5499. http://www.scopus.com/inward/record.url?eid=2-s2.0-37349104891&partnerID=MN8TOARS.
    10.1002/ejic.200700435
  51. Gonçalves, C.; Martins, J.A.; Gama, F.M.. "Self-assembled nanoparticles of dextrin substituted with hexadecanethiol". Biomacromolecules 8 2 (2007): 392-398. http://www.scopus.com/inward/record.url?eid=2-s2.0-33847254019&partnerID=MN8TOARS.
    Publicado • 10.1021/bm060993e
  52. Prata, M.; Torres, S.; Santos, A. C.; Andre, J. P.; Martins, J. A.; Neves, M.; Helm, L.; et al. "A new self-assembling potential liver imaging agent: In vitro characterization and in vivo animal imaging studies". European Journal of Nuclear Medicine and Molecular Imaging 34 (2007): S211-S211. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000253283900438&KeyUID=WOS:000253283900438.
  53. Prata, M.I.; Santos, A.C.; Torres, S.; André, J.P.; Martins, J.A.; Neves, M.; García-Martín, M.L.; et al. "Targeting of lanthanide(III) chelates of DOTA-type glycoconjugates to the hepatic asyaloglycoprotein receptor: cell internalization and animal imaging studies.". Contrast media & molecular imaging 1 6 (2006): 246-258. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947723488&partnerID=MN8TOARS.
    Publicado • 10.1002/cmmi.111
  54. Torres, S.; Martins, J.A.; André, J.P.; Geraldes, C.F.G.C.; Merbach, A.E.; Tóth, É.. "Supramolecular assembly of an amphiphilic GdIII chelate: Tuning the reorientational correlation time and the water exchange rate". Chemistry - A European Journal 12 3 (2006): 940-948. http://www.scopus.com/inward/record.url?eid=2-s2.0-30744441893&partnerID=MN8TOARS.
    Publicado • 10.1002/chem.200500551
  55. Baía, P.; André, J.P.; Geraldes, C.F.G.C.; Martins, J.A.; Merbach, A.E.; Tóth, É.. "Lanthanide(III) chelates of DTPA bis(amide) glycoconjugates: Potential imaging agents targeted at the asyaloglycoprotein receptor". European Journal of Inorganic Chemistry 2005 11 (2005): 2110-2119. http://www.scopus.com/inward/record.url?eid=2-s2.0-20444493273&partnerID=MN8TOARS.
    Publicado • 10.1002/ejic.200400766
  56. André, J.P.; Geraldes, C.F.G.C.; Martins, J.A.; Merbach, A.E.; Prata, M.I.M.; Santos, A.C.; De Lima, J.J.P.; Tóth, É.. "Lanthanide(III) complexes of DOTA-glycoconjugates: A potential new class of lectin-mediated medical imaging agents". Chemistry - A European Journal 10 22 (2004): 5804-5816. http://www.scopus.com/inward/record.url?eid=2-s2.0-9244230554&partnerID=MN8TOARS.
    10.1002/chem.200400187
  57. Martins, J. A. R.; Crout, D. H. G.; Critchley, P.; Martins, J.A.R.; Crout, D.H.G.. "C-n microspheres as surrogate membranes in glycosidase-catalysed hydrolysis of glycolipids". Chemical Communications 10 2 (2003): 198-199. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000188617000033&KeyUID=WOS:000188617000033.
    10.1039/b309154f
  58. Chevolot, Y.; Martins, J.; Milosevic, N.; Leonard, D.; Zeng, S.; Malissard, M.; Berger, E. G.; et al. "Immobilisation on polystyrene of diazirine derivatives of mono- and disaccharides: Biological activities of modified surfaces". Bioorganic & Medicinal Chemistry 9 11 (2001): 2943-2953. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000171753000022&KeyUID=WOS:000171753000022.
    Publicado • 10.1016/s0968-0896(01)00172-9
  59. Leand´onard, D.; Chevolot, Y.; Heger, F.; Martins, J.; Crout, D.H.G.; Sigrist, H.; Mathieu, H.J.. "ToF-SIMS and XPS study of photoactivatable reagents designed for surface glycoengineering: Part III. 5-Carboxamidopentyl-n-[m-[3-(trifluoromethyl)diazirin-3-yl]phenyl-ß- D -galactopyranosyl]-(1->4)-1-thio-ß-D-glucopyranoside (lactose aryl diazirine) on diamond". Surface and Interface Analysis 31 6 (2001): 457-464. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035365231&partnerID=MN8TOARS.
    Publicado • 10.1002/sia.1071
Capítulo de livro
  1. Sérgio R.S. Veloso; Paula M. T. Ferreira; Martins J. A.; Paulo J. G. Coutinho; Elisabete M. S. Castanheira. "Advances in Nanotheranostics with Plasmonic and Magnetic Nanoparticles". In Nanoparticles for Brain Drug Delivery, editado por Carla Vitorino; Andreia Jorge; Alberto A.C.C. Pais. Estados Unidos: . Taylor & Francis CRC Press, 2021.

Propriedade Intelectual

Patente
  1. Marcos, J.C; Martins, José; Silva, P.J.N.M. 2014. "ISOLAMENTO DE DNA PLASMÍDICO EM SISTEMAS DE DUAS FASES AQUOSAS UTILIZANDO POLÍMEROS, PN 105438". Portugal.
  2. Sigrist, H.; Chevolot, Y.; Crout, D.H.G; Martins, José; Mthieu, H-J; Lohmann, D.. 2004. "Preparation of carbohydrate structures on material surfaces, useful to manufacture biomedical devices, comprises photochemical fixation of benzene derivatives and enzymatic attachment of further carbohydrates to radicals of modified surface , US6780980-B1 Patent".
    Concedida/Emitida
Atividades

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2022/01/01 - 2026/12/31 Self-assembled peptide-based photothermal hydrogels: cancer theranostic combining thermo-chemotherapy and MRI imaging (2021.07290.BD)
Orientador
 Doutoramento em Química Aplicada (Doutoramento)
Universidade do Minho Centro de Química, Portugal
2020/09/01 - 2024 Innovative peptide-based self-assembled theranostic hydrogel platform for combined MRI imaging and magnetic hyperthermia-activated cancer thermo-chemotherapy (2020.07743.BD)
Coorientador
 Programa Doutoral em Química (Doutoramento)
Universidade do Minho Centro de Química, Portugal
2018/03/15 - 2023 Dextrin: a platform for the development of drug delivery systems
Coorientador
 Doctoral Program in Biological Engineering (Doutoramento)
Universidade do Minho Centro de Engenharia Biológica, Portugal

Universidade do Minho Centro de Química, Portugal
2019/09/01 - 2021/02/17 Towards injectable theranostic platforms: magnetic peptide-based supramolecular hydrogels with drug-delivery, MRI reporting and hyperthermia capabilities.
Orientador
 Mestrado em Química Medicinal (Mestrado)
Universidade do Minho Centro de Química, Portugal
2019 - 2019 Preparation and characterisation of magnetic dehydropeptide-based hydrogels.
Orientador
 Química Medicinal (Mestrado)
Universidade do Minho, Portugal
2016 - 2016 Synthesis of novel pyridine bis-oxazole ligands for preparation of luminescent Ln(III) metal complexes.
Orientador
 Química Medicinal (Mestrado)
Universidade do Minho, Portugal
2011 - 2015 Synthesis of new peptide derivatives that self-assemble into nanostructured hydrogels for biomedical applications
Coorientador
 phD Chemistry (Doutoramento)
Universidade do Minho Centro de Química, Portugal
2010 - 2014 Multifunctional gold nanoparticles for magnetic resonance imaging (MRI) and therapeutic applications.
Orientador
 PhD (Doutoramento)
Universidade do Minho Centro de Química, Portugal
2013 - 2013 Synthesis, characterization, energy transfer and binding properties of quantum dots and its superstructures
Coorientador
 Química Medicinal (Mestrado)
Universidade do Minho, Portugal
2011/09/01 - 2012/12/01 Gold nanoparticles and quantum dots functionalised with Gd3+ chelates as Contrast Agentes for medical imaging
Orientador
 Mestrado em Química medicinal
Universidade do Minho Centro de Química, Portugal
2011/09/01 - 2012/11/01 Self-assembled non-covalent hydrogels based on dehydrodipeptides
Coorientador
 Mestrado em Química Medicinal (Mestrado)
Universidade do Minho Centro de Química, Portugal
2011 - 2011 Synthesis of new peptide derivates that self-assemble into nanostructured hydrogels for biomedical applications
Coorientador
 Ciências (Doutoramento)
Universidade do Minho, Portugal
2010 - 2010 Optimized molecular imaging agents: from metal chelates to micelles to gold nanoparticles
Orientador
 Ciências (Doutoramento)
Universidade do Minho, Portugal
2007 - 2010 Gadolinium Complexes for Magnetic Resonance Imaging: Synthesis, Characterization and Evaluation of the Pharmacoki-netic Behaviour
Orientador
 Ciências (Doutoramento)
Universidade do Minho, Portugal
2008/09/01 - 2009/12/02 Nanomagnetogels for biomedical apllications
Coorientador
 Mestardo em Micro e Nanotecnologias (Mestrado)
Universidade do Minho Centro de Engenharia Biológica, Portugal
2008/09/01 - 2009/12/02 Paramagnetic gold nanoparticles for magnetic resonance imaging and therapeutic applications
Orientador
 Mestrado em Química medicinal (Mestrado)
Universidade do Minho Centro de Química, Portugal
2003/09/01 - 2004/01/01 Metal complexes of glycoconjugates for medical applications
Orientador
 Mestrado em Química (Mestrado)
Universidade do Minho Centro de Química, Portugal

Tutoria

Tópico Nome do aluno
2010 - 2013 Magnetonanogels: new formulations for drug delivery Catarina Gonçalves