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Maria João Arez completed her Bachelor in Biology at Faculdade de Ciências da Universidade de Lisboa in 2016. She then moved to Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa and completed her MSc in Molecular Genetics and Biomedicine in 2018. She performed her thesis year at Instituto de Medicina Molecular | João Lobo Antunes (iMM|JLA) working on DNA methylation and genomic imprinting and then she was awarded a master fellowship to work as a research technician and to continue her research project. During this time she participated in one international meeting with a poster presentation, in an EMBL Course in Heidelberg and in a submitted publication as an author. She also acquired the Laboratory animal course as well as the scientific writing course certificates. At 2020 she performed an internship at Prof. Simon Hippenmeyer Lab at Institute of Science and Technology in Austria (IST Austria) for four months where she established in vitro model of cortical neurons from Cdkn1c conditional knockout mouse embryonic stem cell. At 2021 she came back to her previous project from which resulted big findings leading to her first author publication that is now under revision in Nature Communications. She has now started her PhD in Bioengineering, specialty of cellular therapy and regenerative medicine at iBB, Instituto Superior Técnico (IST Lisboa) to work on the generation of human iPSCs free of epigenetic defects.
Identificação

Identificação pessoal

Nome completo
Maria João Arez

Nomes de citação

  • Arez, Maria

Identificadores de autor

Ciência ID
F71B-A234-1AA7
ORCID iD
0000-0001-5564-3490

Endereços de correio eletrónico

  • marez@medicina.ulisboa.pt (Profissional)

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador independente (B1) Utilizador proficiente (C1) Utilizador independente (B2) Utilizador independente (B2)
Formação
Grau Classificação
2021/04/05 - 2024
Em curso
PhD in Bioengeneering - Specialty of cellular therapy and regenerative medicine (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico Campus Taguspark, Portugal
2019/09/26 - 2019/12/31
Concluído
Scientific Writing "Structuring and writing a hypothesis-driven research paper" (Outros)
Instituto de Medicina Molecular, Portugal
97%
2019/06/17 - 2019/07/31
Concluído
CONGENTO Course on Laboratory Animal Science (EU, Function A) (Diploma de especialização)
Instituto de Medicina Molecular, Portugal
Aproved
2016/09/06 - 2018/10/23
Concluído
Genética Molecular e Biomedicina (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Comprehensive Evaluation of Genomic Imprinting Stability in Mouse iPSCs" (TESE/DISSERTAÇÃO)
17
2013/09/06 - 2016/07/06
Concluído
Biologia (Licenciatura)
Especialização em Biologia Molecular e Genética
Universidade de Lisboa Faculdade de Ciências, Portugal
16
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2021/04/05 - Atual Investigador (Investigação) Fundação para a Ciência e a Tecnologia, Portugal
Universidade de Lisboa Instituto Superior Técnico Campus Taguspark, Portugal
2021/01/01 - 2021/03/31 Investigador (Investigação) Fundação para a Ciência e a Tecnologia, Portugal
Instituto de Medicina Molecular, Portugal
2020/09/15 - 2020/12/31 Estagiário de Investigação (Investigação) Institute of Science and Technology Austria, Áustria
Institute of Science and Technology Austria, Áustria
2019/01/07 - 2020/08/31 Investigador (Investigação) Fundação para a Ciência e a Tecnologia, Portugal
Instituto de Medicina Molecular, Portugal
2017/09/23 - 2018/10/23 Estagiário de Investigação (Investigação) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
Instituto de Medicina Molecular, Portugal
2016/02/20 - 2016/07/06 Estagiário de Investigação (Investigação) Universidade de Lisboa Faculdade de Ciências, Portugal
Universidade de Lisboa - Tec Labs Centro de Inovação, Portugal
Projetos

Outro

Designação Financiadores
2021/04/05 - Atual Assessing the impact of imprinting defects in human iPSCs: Is cell therapy safe?
UI/BD/151251/2021
Bolseiro de Doutoramento
Em curso
2019/01/07 - 2021/03/31 The aging epigenetic barriers in cell reprogramming
PTDC/BIA-MOL/29320/2017
Bolseiro de Mestrado
Instituto de Medicina Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
Produções

Publicações

Artigo em revista
  1. Silva, Teresa P.; Pereira, Carolina A.; Raposo, Ana Cláudia; Oliveira, Ana Rita; Arez, Maria; Cabral, Joaquim M.S.; Milagre, Inês; Carmo-Fonseca, Maria; Rocha, Simão Teixeira da. "Generation and characterization of induced pluripotent stem cells heterozygous for the Portuguese BRCA2 founder mutation". Stem Cell Research 53 (2021): 102364. http://dx.doi.org/10.1016/j.scr.2021.102364.
    Publicado • 10.1016/j.scr.2021.102364
  2. Silva, Teresa P.; Pereira, Carolina A.; Oliveira, Ana Rita; Raposo, Ana Cláudia; Arez, Maria; Cabral, Joaquim M.S.; Milagre, Inês; Carmo-Fonseca, Maria; da Rocha, Simão T.. "Generation and characterization of induced pluripotent stem cells from a family carrying the BRCA1 mutation c.3612delA". Stem Cell Research 52 (2021): 102242. http://dx.doi.org/10.1016/j.scr.2021.102242.
    Publicado • 10.1016/j.scr.2021.102242
  3. Arez, Maria; Eckersley-Maslin, Melanie; Klobucar, Tajda; von Gilsa Lopes, João; Krueger, Felix; Raposo, Ana Cláudia; Gendrel, Anne-Valerie; Bernardes de Jesus, Bruno; da Rocha, Simão T.. Autor correspondente: da Rocha, Simão T.. "Sex of donor cell and reprogramming conditions predict the extent and nature of imprinting defects in mouse iPSCs". Nature Communications (BioRxiv) (2020): https://www.biorxiv.org/content/10.1101/2020.11.20.370973v1.
    Submetido
  4. Klobucar, Tajda; Kreibich, Elisa; Krueger, Felix; Arez, Maria; Pólvora-Brandão, Duarte; von Meyenn, Ferdinand; da Rocha, Simão Teixeira; Eckersley-Maslin, Melanie. "IMPLICON: an ultra-deep sequencing method to uncover DNA methylation at imprinted regions". Nucleic Acids Research 48 16 (2020): e92-e92. http://dx.doi.org/10.1093/nar/gkaa567.
    Publicado • 10.1093/nar/gkaa567
Poster em conferência
  1. Arez, Maria; Eckersley-Maslin, Melanie; Von Gilsa, João; GENDREL, ANNE-VALERIE; Raposo, Ana; Bernardes de Jesus, Bruno; da Rocha, Simão T.. "Comprehensive Evaluation of Genomic Imprinting Stability in Mouse iPSCs". Trabalho apresentado em 11th Edition of the International Meeting of the Portuguese Society for Stem Cells & Cell Therapies, 2019.
Resumo em conferência
  1. Arez, Maria. "Comprehensive Evaluation of Genomic Imprinting Stability in Mouse iPSCs". Trabalho apresentado em SPCE-TC 2019 – 11th Edition of the International Meeting of the Portuguese Society for Stem Cells & Cell Therapies, Lisbon, 2019.
    Publicado
Tese / Dissertação
  1. Arez, Maria. "Comprehensive Evaluation of Genomic Imprinting Stability in Mouse iPSCs". Mestrado, Instituto de Medicina Molecular, 2018.
Atividades

Participação em evento

Descrição da atividade
Tipo de evento
Nome do evento
Instituição / Organização
2019/09/26 - 2019/12/31 In this scientific writing course I wrote a full hypothesis-driven research paper according to the IMRAD (Introduction, Material and Methods, Results and Discussion) format. I also learnt the steps involved in producing and publishing a research paper and how to use the language (English) in order to produce an article that effectively conveys its message.
Outro
Scientific Writing “Structuring and writing a hypothesis-driven research paper”
Instituto de Medicina Molecular, Portugal
2019/12/02 - 2019/12/05 In the EMBL Course: Enzymatic Methyl-seq: Bisulfite-Free Methylation Analysis we prepared and analysed "bisulfite-free" methylome libraries for Illumina sequencing using a novel enzymatic approach to detect 5-methyl cytosines that results in longer reads and higher coverage of genomic features at lower minimum coverage thresholds when compared to Illumina bisulfite libraries.
Outro
EMBL Course: Enzymatic Methyl-seq: Bisulfite-Free Methylation Analysis
EMBL Heidelberg Genome Biology, Alemanha
2019/10/10 - 2019/10/12 The 11th Edition of the International Meeting of the Portuguese Society for Stem joined researchers coming from academia, health care institutions and industry to discuss topics such as stem cell reprogramming and advancements in cancer stem cell research, tissue engineering, stem cell transplantation, manipulation of the stem cell genome in a research context, and current trends in regenerative medicine. Young researchers had the opportunity to network, exchange ideas and to be inspired by top-level speakers and invited opinion leaders.
Encontro
11th Edition of the International Meeting of the Portuguese Society for Stem Cells & Cell Therapies
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/06/17 - 2019/07/31 The CONGENTO Course on Laboratory Animal Science included 20h of theoretical course in laboratory animal science as recommended by FELASA (category B) which was complemented with pratical training of rodents and zebrafish.
Outro
CONGENTO Course on Laboratory Animal Science (EU, Function A)
Instituto de Medicina Molecular, Portugal

Tutoria

Tópico Nome do aluno
2019/05/07 - 2019/08/07 Laboratorial Supervision Tajda Klobucar
2018/07/10 - 2018/08/10 Techniques teaching Patrícia Quelhas