Ana Rita Guerreiro de Brito Petronilho (1E17-D714-9123)

Curriculum Vitae

Ana Rita Guerreiro de Brito Petronilho

Ana Petronilho is the leader of the Bioorganometallic Chemistry Group at ITQB-NOVA since 2015. Her research is focused on the synthesis of organometallic nucleosides, in particular N-heterocyclic carbenes based on nucleosides, and their applications in medicinal chemistry and catalysis. Ana graduated in Chemistry in 2004, from Instituto Superior Técnico. In 2010, she concluded her PhD at the University of Seville under the supervision of Prof. Carmona, working in synthetic methodologies for C-H activation of pyridines with iridium complexes. During this period, Ana completed also a Master in Teaching for Higher Education from UNED. In 2011, she joined the group of Prof. M. Albrecht at UCD, Ireland, to work in synthesis of catalysts for artificial photosynthesis. In June 2015, after a short career break, she started her independent career at ITQB-NOVA after being awarded the FCT Starting Investigator Grant. Since then, Ana and her team have worked extensively in the development of new methodologies for the synthesis of organometallic nucleosides and their applications. Her current work deals with methodologies for functionalization of nucleic acids with metal complexes.

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Identification

Personal identification

Full name: Ana Rita Guerreiro de Brito Petronilho

Citation names

Petronilho, Ana

Author identifiers

Ciência ID: 1E17-D714-9123
ORCID iD: 0000-0002-3296-1522

Knowledge fields

Exact Sciences - Chemical Sciences - Inorganic Chemistry

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)
Spanish; Castilian	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)
French	Intermediate (B1)	Intermediate (B1)	Intermediate (B1)	Upper intermediate (B2)	Intermediate (B1)

Education

	Degree	Classification
2023/02 - 2023/06 Ongoing	Posgraduação em politica de Genero: Igualdade e Não-Discriminação-UNESCO Chair (Pós-Graduação) Universidade de Évora, Portugal
2010 - 2011 Concluded	Formación del Profesorado en Docencia e Investigación para la Educación Superior (Mestrado) Universidad Nacional de Educación a Distancia, Spain "Virtual Labs in Chemistry" (THESIS/DISSERTATION)	Aprovado
2005 - 2010 Concluded	Organometallic Chemistry (Doctor of Philosophy) Universidad de Sevilla, Spain "Tautomería de heterociclos nitrogenados mediante complejos de iridio(III) com formación de carbenos N-heterocíclicos" (THESIS/DISSERTATION)	suma cum laude
2007 Concluded	Organometallic Chemistry (DEA) Universidad de Sevilla, Spain "Isomerization of N-Heterocycles by Iridium Complexes" (THESIS/DISSERTATION)	Sobresaliente
2004 Concluded	Chemistry (Licenciatura) Major in Chemistry Universidade de Lisboa Instituto Superior Técnico, Portugal "Reactivity of Ethers and Amines with Iridium Complexes" (THESIS/DISSERTATION)	15

Affiliation

Science

	Category Host institution	Employer
2020/03/01 - Current	Auxiliary Researcher (Research)	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

2015/06/15 - 2020/06/14	Auxiliary Researcher (Research)	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

2014/11/01 - 2015/05/24	Science and Technology Management	Science Foundation Ireland, Ireland

2011/02/01 - 2014/10/31	Postdoc (Research)	University College Dublin, Ireland

2010/07/01 - 2010/12/31	Postdoc (Research)	Consejo Superior de Investigaciones Científicas Delegación en Andalucía, Spain

2005/09/01 - 2010/06/24	Researcher (Research)	Universidad de Sevilla, Spain

Projects

Grant

	Designation	Funders
2023/04/01 - 2024/03/31	Stressing Out: Promoting Antifungal Activity by Fostering Reductive Stress with Metal Complexes n/a Principal investigator Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Ongoing
2022/09/01 - 2023/08/31	Development of highly selective nickel complexes for the treatment of Candida spp. infections INNOVALEU Prof of concept Principal investigator	Camara Municipal Oeiras
2019/09/01 - 2021/08/31	(Co-PI) - Chemical Synthesis Using Earth-Abundant Metal Catalysts PTDC/QUI-QIN/28151/2017 Principal investigator Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2015/06 - 2020/06	Projecto Exploratório: On the impact of carbene formation on DNA IF/00109/2014/CP1244/CT0007	Fundação para a Ciência e a Tecnologia
2017/09/01 - 2018/08/31	Development of Novel AZT Derivatives Based on Triazoles NOVASAUDE 2017 Principal investigator Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal	Universidade Nova de Lisboa Concluded
2017/02/01 - 2018/01/31	Rethinking azoles as antifungals: New tricks for old drugs MostMicro Interline projects Principal investigator Universidade Nova de Lisboa Microbiologia Molecular Estrutural e Celular, Portugal	Universidade Nova de Lisboa Microbiologia Molecular Estrutural e Celular Concluded
2017/02 - 2018/01	Rethinking azoles as antifungals: New tricks for old drugs MostMicro Interline projects	Universidade Nova de Lisboa Microbiologia Molecular Estrutural e Celular
2007/01/01 - 2010/12/31	Desarrollo de entidades organometálicas para reacciones de funcionalización selectiva en moléculas orgánicas Consolider-Ingenio 2010 CSD2007-00006 PhD Student Fellow Consejo Superior de Investigaciones Científicas Delegación en Andalucía, Spain	Gobierno de Espana Ministerio de Educación Cultura y Deporte Concluded
2006/03/01 - 2009/02/28	Síntesis de compuestos organometálicos de Rh, Ir y Pt. Activación y funcionalización de enlaces C-H de los hidrocarburo EXC/2005/FQM-672 200780I006 200780I006 PhD Student Fellow Instituto De Investigaciones Quimicas, Spain	Junta de Andalucía Concluded

Contract

	Designation	Funders
2020/03/01 - Current	CEEC Inst CEECINST/00102/2018/CP1567/CT0043 Principal investigator Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Ongoing
2021/01/01 - 2025/12/31	Life Sciences for a Healthy and Sustainable Future LA/P/0087/2020 Universidade Nova de Lisboa Microbiologia Molecular Estrutural e Celular, Portugal Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal Fundação Calouste Gulbenkian, Portugal Instituto Gulbenkian de Ciência, Portugal Instituto de Biologia Experimental e Tecnológica, Portugal BioResources 4 Sustainability, Portugal Universidade NOVA de Lisboa, Portugal iNOVA4Health, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2015/06/15 - 2020/06/14	Investigador FCT IF/00109/2014 Principal investigator Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2019/01/01 - 2019/12/31	Molecular, Structural and Cellular Microbiology (Afliliated member) UID/CBQ/04612/2019 Universidade NOVA de Lisboa, Portugal Universidade Nova de Lisboa Microbiologia Molecular Estrutural e Celular, Portugal Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2013/10/01 - 2014/10/31	Mesoionic complexes for redox catalysis SSPC Post-doc Fellow University College Dublin, Ireland	Science Foundation Ireland
2012/10/01 - 2013/09/30	Mesoionic carbene complexes for water splitting: Harnessing renewable energy sources info:eu-repo/grantAgreement/EC/SEVENTH FRAMEWORK PROGRAMME/324609/EU Post-doc Fellow	European Research Council
2011/02/01 - 2013/01/31	New water splitting catalysts carbenzymes Post-doc Fellow University College Dublin, Ireland	European Research Council Concluded
2006/12/01 - 2010/12/24	Tautomerisation of N-heterocyclics induces by transition metal complexes. (PhD Fellowship) SFRH/BD/28240/2006 PhD Student Fellow Instituto De Investigaciones Quimicas, Spain Universidad de Sevilla, Spain	Fundação para a Ciência e a Tecnologia Concluded
2005/09/01 - 2006/11/30	C-H activation of N-Heterocycles mediated by Iridium complexes BES2005-10024 PhD Student Fellow	Gobierno de Espana Ministerio de Educación Cultura y Deporte Concluded

Outputs

Publications

Book	Petronilho, A.; Albrecht, M.. CHAPTER 3: Non-Classical N-Heterocyclic Carbene Complexes. 2017. 10.1039/9781782626817-00099
Conference paper	Giulia Orsini. "Synthesis of Platinum Complexes based on Uracil". Paper presented in 13th Inorganic & Bioinorganic Chemistry Conference, Aveiro, 2022.
Conference poster	Giulia Orsini. "Synthesis of Metallanucleosides based on Adenosine". Paper presented in 8th Latin American Symposium on Coordination and Organometallic Chemistry, 2023. Giulia Francescato. "Nickel N-Heterocyclic Carbenes based on Xanthines: Synthesis and Antifungal Activity". Paper presented in 44th ICCCInternational Conference on Coordination Chemistry, 2022. Petronilho, Ana. "Synthesis of Organometallic nucleosides based on uracil". Paper presented in 44th ICCC International Conference on Coordination Chemistry, Rimini, Italy, 28 August - 2 September 2022, 2022. Ana Carolina Gaspar-Cordeiro; Catarina Amaral; Pissarro, Teresa; Cláudia M. Luís; Vânia Pobre; Wilson Antunes; Lima, Luís M. P.; et al. "Copper potentiates fluconazole activity against Candida glabrata". Paper presented in ASM Microbe, 2022. Giuia Francescato. "Synthesis of an Iridium Complex Bearing a Mesoionic Carbene based on Uracil". Paper presented in 8th Latin American Symposium on Coordination and Organometallic Chemistry, 2022. Francescato, Giulia; sofia marques da Silva; Catarina Pimentel; Ana Petronilho. Corresponding author: Ana Petronilho. "Xanthine-based N-heterocyclic carbenes: Synthesis and antifungal activity". Paper presented in 24th Virtual Conference on Organometallic Chemistry (EuCOMC XXIV Virtual Conference), Madrid (SPAIN),, 2021. Francescato, Giulia; Ana Petronilho. Corresponding author: Ana Petronilho. "Xanthine-based N-heterocyclic carbenes with nickel: Synthesis and applications, Ciência 2021". Paper presented in Ciência 2021 - Science and Technology in Portugal Summit, 2021. Maria Inês P. S. Leitão; Francescato, Giulia; Ana Petronilho. "Metallanucleosides based on Adenosine". Paper presented in Ciência 2021 - Science and Technology in Portugal Summit,, 2021. Francescato, Giulia; Petronilho, Ana; Maria Inês P. S. Leitão. Corresponding author: Petronilho, Ana. "Synthesis, characterization and antifungal activity of a new caffeine-based Nickel NHC". Paper presented in XXVI Encontro da Sociedade Portuguesa de Química, 2019. Petronilho, Ana; Leitão, Maria Inês. "On the Reactivity of mRNA Caps: C-H Oxidative Addition of 7-Methyguanosine to Pt(0)". Paper presented in XXVI Encontro da Sociedade Portuguesa de Química, 2019. Petronilho, Ana; Maria Inês P. S. Leitão. Corresponding author: Petronilho, Ana. "Bio-Relevant N-Heterocyclic Carbenes Derived from RNA caps Formation in Purine Nucleosides". Paper presented in 1st Stable Carbene Symposium, Toulouse, France, 2018. Petronilho, Ana; Maria Inês P. S. Leitão; Nicolaus Gianopoulos. "Caffeine based Nickel(II) N-heterocyclic carbenes: synthesis and catalytic applications.". Paper presented in 12th IBCC – Inorganic and Bioinorganic Chemistry Conference of the Division of Inorganic and Bioinorganic Chemistry of SPQ, Porto, 2018. Petronilho, Ana; Maria Inês P. S. Leitão. "Base Pairing effects of N-Heterocyclic Carbene Formation in Purine Nucleosides". Paper presented in 28th International Conference in Organometallic Chemistry, Florence, Italy, 2018, 2018. Maria Inês P. S. Leitão; Federico Herrera; Petronilho, Ana. Corresponding author: Petronilho, Ana. "Metal N-heterocyclic carbenes as anticancer agents.". Paper presented in MedChemSicily2018,, Palermo, Italy, 2018. Petronilho, Ana; Zuzanna Filipiak. "N-Heterocyclic carbenes derived from 7-methylguanosine". Paper presented in 6th Portuguese Young Chemists Meeting, 2018. Petronilho, Ana; Maria Inês P. S. Leitão; Federico Herrera. "Cytotoxic Activity of N-Heterocyclic Carbenes Derived from Guanosine.". Paper presented in 12th National Organic Chemistry Meeting – 12ENQO, Coimbra,, 2018. Petronilho, Ana; Maria Inês P. S. Leitão. Corresponding author: Petronilho, Ana. "Synthesis of Palladium and Platinum N-Heterocyclic Carbenes Based on Nucleosides". Paper presented in XXII EUChems Organometallic Chemistry, Amsterdam, The Netherlands, 2017., 2017. Petronilho, Ana; Maria Inês P. S. Leitão. Corresponding author: Petronilho, Ana. "Base-Pairing Effects of N-Heterocyclic Carbene Formation in Nucleosides". Paper presented in XXV Encontro da Sociedade Portuguesa de Química, Lisbon, Portugal, 2017., 2017. Maria Inês P. S. Leitão; Petronilho, Ana. Corresponding author: Petronilho, Ana. "Synthesis of N-heterocyclic Carbenes Derived from Guanine". Paper presented in 5th COST CARISMA, Lisbon, Portugal, 2017., 2017. Petronilho, Ana; Maria Inês P. S. Leitão. "Synthetic Approaches for N-heterocyclic Carbenes Derived from Nucleosides,". Paper presented in 42nd International Conference in Coordination Chemistry, Brest, France, 2016, 2016. Petronilho, Ana. "Bioorganometallic Chemistry". Paper presented in MostMicro Kick-Off Meeting, Estoril, Portugal, 2015, 2015. Petronilho, Ana; Martin Albrecht. "Iridium Mesoionic Carbene Complexes as Catalysts for Water Oxidation". Paper presented in ISACS12: Challenges in Chemical Renewable Energy, Cambridge, UK, 2013. Petronilho, Ana; Martin Albrecht. "Carbene Iridium Complexes as Catalysts for Water Oxidation". Paper presented in Dalton Discussions 13: Inorganic Photophysics and Photochemistry, Fundamentals and Applications, Sheffield, UK, 2012, 2012. Petronilho, Ana; Martin Albrecht. "Catalytic Water Oxidation Using Iridium Abnormal Carbene Complexes". Paper presented in XIX EuCHEMS Conference in Organometallic Chemistry, Toulouse, France, 2011, 2011. Petronilho, Ana; Manuel Poveda; Ernesto Carmona; Margarita Paneque. "Light Induced Transformations of an Ir(III) Pyridylidene Complex in Deuterated Chloroform". Paper presented in CONSOLIDER Meeting, Oviedo, Spain, 2010., 2010. Petronilho, Ana; Salvador Conejero; Ernesto Carmona; Margarita Paneque; Manuel Poveda. "Reactividad de carbenos N-Heterocíclicos derivados de piridinas". Paper presented in CONSOLIDER Meeting, Ciudad Real, Spain, 2008., 2008. Petronilho, Ana; Ernesto Carmona; Salvador Conejero; Manuel Poveda; Margarita Paneque. "Stabilization of Carbene Tautomers Derived from N-Heterocycles by Ir(III) complexes.". Paper presented in XX Encontro Nacional Sociedade Portuguesa de Quimica, Monte da Caparica, Portugal, 2006, 2006. Petronilho, Ana; Salvador Conejero; Margarita Paneque; Ernesto Carmona; Manuel Poveda. "An Unusual 1,2 Hydrogen-shift in 2-substituted Pyridines leading to N-heterocyclic carbenes". Paper presented in XXII International Conference on Organometallic Chemistry, Zaragoza, Spain, 2006., 2006. 10.1109/icton.2006.248291 Petronilho, Ana; Dr.Manuel L. Poveda, Dr. Margarita Paneque; Manuel Poveda; Margarita Gomez. "Reactividad de metalaciclos de Iridío". Paper presented in XXX Reunión Bienal de la Real Sociedad Española de Química, Lugo, Spain, 2005., 2005. Petronilho, Ana; Laura Lopez Santos; Manuel Poveda; Ernesto Carmona. "Activación de n-Metil éteres mediante complejos de TpMe2Ir". Paper presented in Reunión del Grupo Especializado en Química Organometállica, Ciudad Real, Spain, 2004, 2004.
Journal article	Leitão, Maria Inês P. S.; Orsini, Giulia; Murtinheira, Fernanda; Gomes, Clara S. B.; Herrera, Federico; Petronilho, Ana. Corresponding author: Herrera, Federico. "Synthesis, Base Pairing Properties, and Biological Activity Studies of Platinum(II) Complexes Based on Uracil Nucleosides". Inorganic Chemistry 62 40 (2023): 16412-16425. http://dx.doi.org/10.1021/acs.inorgchem.3c02071. 10.1021/acs.inorgchem.3c02071 Maria Inês P. S. Leitão; Maria Turos-Cabal; Ana Maria Sanchez-Sanchez; Clara S. B. Gomes; Federico Herrera; Vanesa Martin; Ana Petronilho. "Antitumor Activity and Reductive Stress by Platinum(II) N-Heterocyclic Carbenes based on Guanosine*". Chemistry – A European Journal* (2023): https://doi.org/10.1002/chem.202301078. 10.1002/chem.202301078 Nuno Maulide; Ana Rita Petronilho. "Basta um Clique: O Prémio Nobel da Química de 2022". Boletim da Sociedade Portuguesa de Química (2023): 5. http://dx.doi.org/10.52590/m3.p704.a30002589. 10.52590/m3.p704.a30002589 Lees, James; Gorini, Lucrezia; Torjussen, Stian; Oliveira, Margarida; Pinto, Paula; Potes Barbas, Maria; Martins, Madalena; et al. "Transnational cooperation in enhancing researchers’ wider employability: the TRANSPEER project". Studies in Graduate and Postdoctoral Education 14 1 (2022): 19-25. http://dx.doi.org/10.1108/sgpe-12-2021-0083. 10.1108/sgpe-12-2021-0083 Gaspar-Cordeiro, Ana; Amaral, Catarina; Pobre, Vânia; Antunes, Wilson; Petronilho, Ana; Paixão, Paulo; Matos, António P.; Pimentel, Catarina. "Copper Acts Synergistically With Fluconazole in Candida glabrata by Compromising Drug Efflux, Sterol Metabolism, and Zinc Homeostasis". Frontiers in Microbiology 13 (2022): http://dx.doi.org/10.3389/fmicb.2022.920574. 10.3389/fmicb.2022.920574 Giulia Francescato; Sofia M. da Silva; Maria Inês P. S. Leitão; Ana Gaspar-Cordeiro; Nikolaos Giannopoulos; Clara S. B. Gomes; Catarina Pimentel; Ana Petronilho. "Nickel N-heterocyclic carbene complexes based on xanthines: Synthesis and antifungal activity on Candida sp.". Applied Organometallic Chemistry (2022): https://doi.org/10.1002/aoc.6687. 10.1002/aoc.6687 de Alencar, Daniel Machado; Gonçalves, Juliana; Vieira, Andreia; Cerqueira, Sofia A.; Sebastião, Cruz; Leitão, Maria Inês P. S.; Francescato, Giulia; et al. Corresponding author: Petronilho, Ana. "Development of Triazoles and Triazolium Salts Based on AZT and Their Anti-Viral Activity against HIV-1". Molecules 26 21 (2021): 6720. http://dx.doi.org/10.3390/molecules26216720. Published • 10.3390/molecules26216720 Leitão, Maria Inês P. S.; Francescato, Giulia; Gomes, Clara S. B.; Petronilho, Ana. Corresponding author: Petronilho, Ana. "Synthesis of Platinum(II) N-Heterocyclic Carbenes Based on Adenosine". Molecules 26 17 (2021): 5384. http://dx.doi.org/10.3390/molecules26175384. Published • 10.3390/molecules26175384 Leitão, Maria Inês P. S.; Gonzalez, Carmen; Francescato, Giulia; Filipiak, Zuzanna; Petronilho, Ana. Corresponding author: Petronilho, Ana. "On the reactivity of mRNA Cap0: C–H oxidative addition of 7-methylguanosine to Pt0 and base pairing studies". Chemical Communications 56 87 (2020): 13365-13368. http://dx.doi.org/10.1039/d0cc06075e. 10.1039/d0cc06075e Maria Inês P. S. Leitão; Herrera, Federico; Petronilho, Ana. Corresponding author: Petronilho, Ana. "On the Reactivity of mRNA Caps: C-H Oxidative Addition of 7-Methylguanosine to Pt(0)". ChemRxiv (2019): http://dx.doi.org/10.26434/chemrxiv.8144297.v1. 10.26434/chemrxiv.8144297.v1 Leitão, Maria Inês P. S.; Herrera, Federico; Petronilho, Ana. Corresponding author: Petronilho, Ana. "N-Heterocyclic Carbenes Derived from Guanosine: Synthesis and Evidences of Their Antiproliferative Activity". ACS Omega 3 11 (2018): 15653-15656. http://dx.doi.org/10.1021/acsomega.8b02387. 10.1021/acsomega.8b02387 Vivancos, Á.; Petronilho, A.; Cardoso, J.; Müller-Bunz, H.; Albrecht, M.. Corresponding author: Albrecht, M.. "Unveiling the role of ancillary ligands in acceptorless benzyl alcohol dehydrogenation and etherification mediated by mesoionic carbene iridium complexes". Dalton Transactions 47 1 (2018): 74-82. http://www.scopus.com/inward/record.url?eid=2-s2.0-85038640912&partnerID=MN8TOARS. 10.1039/c7dt04109h Petronilho, A.; Vivancos, A.; Albrecht, M.. Corresponding author: Albrecht, M.. "Ether formation through reductive coupling of ketones or aldehydes catalyzed by a mesoionic carbene iridium complex". Catalysis Science & Technology 7 23 (2017): 5766-5774. http://dx.doi.org/10.1039/c7cy01832k. 10.1039/c7cy01832k Corbucci, I.; Petronilho, A.; Müller-Bunz, H.; Rocchigiani, L.; Albrecht, M.; Macchioni, A.. "Substantial improvement of pyridine-carbene iridium water oxidation catalysts by a simple methyl-to-octyl substitution". ACS Catalysis 5 5 (2015): 2714-2718. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928969707&partnerID=MN8TOARS. 10.1021/acscatal.5b00319 Petronilho, A.; Mueller-Bunz, H.; Albrecht, M.. "Iridium, ruthenium, and palladium complexes containing a mesoionic fused imidazolylidene ligand". Journal of Organometallic Chemistry 775 (2015): 117-123. http://www.scopus.com/inward/record.url?eid=2-s2.0-84915753832&partnerID=MN8TOARS. 10.1016/j.jorganchem.2014.03.021 Petronilho, A.; Woods, J.A.; Bernhard, S.; Albrecht, M.. "Bimetallic iridium-carbene complexes with mesoionic triazolylidene ligands for water oxidation catalysis". European Journal of Inorganic Chemistry 4 (2014): 708-714. http://www.scopus.com/inward/record.url?eid=2-s2.0-84893305518&partnerID=MN8TOARS. 10.1002/ejic.201300843 Petronilho, A.; Woods, J.A.; Mueller-Bunz, H.; Bernhard, S.; Albrecht, M.. "Iridium complexes containing mesoionic C donors: selective C(sp3)-H versus C(sp2)-H bond activation, reactivity towards acids and bases, and catalytic oxidation of silanes and water". Chemistry (Weinheim an der Bergstrasse, Germany) 20 48 (2014): 15775-15784. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938514140&partnerID=MN8TOARS. 10.1002/chem.201404776 Woods, J.A.; Lalrempuia, R.; Petronilho, A.; McDaniel, N.D.; Müller-Bunz, H.; Albrecht, M.; Bernhard, S.. "Carbene iridium complexes for efficient water oxidation: Scope and mechanistic insights". Energy and Environmental Science 7 7 (2014): 2316-2328. http://www.scopus.com/inward/record.url?eid=2-s2.0-84902957534&partnerID=MN8TOARS. 10.1039/c4ee00971a Petronilho, A.; Llobet, A.; Albrecht, M.. "Ligand exchange and redox processes in iridium triazolylidene complexes relevant to catalytic water oxidation". Inorganic Chemistry 53 24 (2014): 12896-12901. http://www.scopus.com/inward/record.url?eid=2-s2.0-84920143556&partnerID=MN8TOARS. 10.1021/ic501894u Wei, Y.; Petronilho, A.; Mueller-Bunz, H.; Albrecht, M.. "Mesoionic triazolylidene nickel complexes: Synthesis, ligand lability, and catalytic C-C bond formation activity". Organometallics 33 20 (2014): 5834-5844. http://www.scopus.com/inward/record.url?eid=2-s2.0-84907777583&partnerID=MN8TOARS. 10.1021/om500593s Canseco-Gonzalez, D.; Petronilho, A.; Mueller-Bunz, H.; Ohmatsu, K.; Ooi, T.; Albrecht, M.. "Carbene transfer from triazolylidene gold complexes as a potent strategy for inducing high catalytic activity". Journal of the American Chemical Society 135 35 (2013): 13193-13203. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883716123&partnerID=MN8TOARS. 10.1021/ja406999p Cristõbal, C.; Hernández, Y.A.; Lõpez-Serrano, J.; Paneque, M.; Petronilho, A.; Poveda, M.L.; Salazar, V.; et al. "Reactivity studies of iridium pyridylidenes [Tp^Me2Ir(C 6H5)2(C(CH)3C(R)N H] (R=H, Me, Ph)". Chemistry - A European Journal 19 12 (2013): 4003-4020. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874996199&partnerID=MN8TOARS. 10.1002/chem.201203818 Donnelly, K.F.; Petronilho, A.; Albrecht, M.. "Application of 1,2,3-triazolylidenes as versatile NHC-type ligands: Synthesis, properties, and application in catalysis and beyond". Chemical Communications 49 12 (2013): 1145-1159. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872344009&partnerID=MN8TOARS. 10.1039/c2cc37881g Conejero, S.; Maya, C.; Paneque, M.; Petronilho, A.; Poveda, M.L.; Vattier, F.; Álvarez, E.; et al. "Iridium(iii) complexes with polypyridine ligands coordinated as N-heterocyclic carbenes. Synthesis, structure and photophysical properties". Dalton Transactions 41 46 (2012): 14126-14136. http://www.scopus.com/inward/record.url?eid=2-s2.0-84868652295&partnerID=MN8TOARS. 10.1039/c2dt31754k Petronilho, A.; Rahman, M.; Woods, J.A.; Al-Sayyed, H.; Müller-Bunz, H.; Don MacElroy, J.M.; Bernhard, S.; Albrecht, M.. "Photolytic water oxidation catalyzed by a molecular carbene iridium complex". Dalton Transactions 41 42 (2012): 13074-13080. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867393625&partnerID=MN8TOARS. 10.1039/c2dt30403a Conejero, S.; López-Serrano, J.; Paneque, M.; Petronilho, A.; Poveda, M.L.; Vattier, F.; Alvarez, E.; Carmona, E.. "Tautomerisation of 2-substituted pyridines to N-heterocyclic carbene ligands induced by the 16 e ^- unsaturated [Tp ^Me2Ir ^III(C 6H 5) 2] moiety". Chemistry - A European Journal 18 15 (2012): 4644-4664. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859227401&partnerID=MN8TOARS. 10.1002/chem.201103507 Petronilho, A.; Müller-Bunz, H.; Albrecht, M.. "Mesoionic oxides: Facile access from triazolium salts or triazolylidene copper precursors, and catalytic relevance". Chemical Communications 48 52 (2012): 6499-6501. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862223749&partnerID=MN8TOARS. 10.1039/c2cc32843g Álvarez, E.; Hernández, Y.A.; López-Serrano, J.; Maya, C.; Paneque, M.; Petronilho, A.; Poveda, M.L.; et al. "Metallacyclic pyridylidene structures from reactions of terminal pyridylidenes with alkenes and acetylene". Angewandte Chemie - International Edition 49 20 (2010): 3496-3499. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952403892&partnerID=MN8TOARS. 10.1002/anie.201000608 Conejero, S.; Lara, P.; Paneque, M.; Petronilho, A.; Poveda, M.L.; Serrano, O.; Vattier, F.; et al. "Monodentate, N-heterocyclic carbene-type coordination of 2,2'-bipyridine and 1,10-phenanthroline to iridium". Angewandte Chemie - International Edition 47 23 (2008): 4380-4383. http://www.scopus.com/inward/record.url?eid=2-s2.0-53549115645&partnerID=MN8TOARS. 10.1002/anie.200800705 Álvarez, Eleuterio; Paneque, Margarita; Petronilho, Ana G.; Poveda, Manuel L.; Santos, Laura L.; Carmona, Ernesto; Mereiter, Kurt. Corresponding author: Carmona, Ernesto. "Activation of Aliphatic Ethers by TpMe2Ir Compounds:¿ Multiple C-H Bond Activation and C-C Bond Formation". Organometallics 26 5 (2007): 1231-1240. http://dx.doi.org/10.1021/om0609822. 10.1021/om0609822 Álvarez, E.; Conejero, S.; Lara, P.; López, J.A.; Paneque, M.; Petronilho, A.; Poveda, M.L.; et al. "Rearrangement of pyridine to its 2-carbene tautomer mediated by iridium". Journal of the American Chemical Society 129 46 (2007): 14130-14131. http://www.scopus.com/inward/record.url?eid=2-s2.0-36448953136&partnerID=MN8TOARS. 10.1021/ja075685i Alvarez, E.; Conejero, S.; Paneque, M.; Petronilho, A.; Poveda, M.L.; Serrano, O.; Carmona, E.. "Iridium(III)-induced isomerization of 2-substituted pyridines to N-heterocyclic carbenes". Journal of the American Chemical Society 128 40 (2006): 13060-13061. http://www.scopus.com/inward/record.url?eid=2-s2.0-33749518082&partnerID=MN8TOARS. 10.1021/ja0646592
Preprint	Maria Inês Leitão; Giulia Orsini; Fernanda Murtinheira; Clara Gomes; Federico Herrera; Ana Petronilho. "Synthesis and Base Pairing Properties of Platinum(II) Nucleosides Based on Uracil". 2023. https://doi.org/10.26434/chemrxiv-2022-6k01r-v2. 10.26434/chemrxiv-2022-6k01r-v2 Maria Inês Leitão; Giulia Orsini; Ana Petronilho. "Synthesis and Base Pairing Properties of Platinum(II) Nucleosides Based on Uracil". 2022. https://doi.org/10.26434/chemrxiv-2022-6k01r. 10.26434/chemrxiv-2022-6k01r Maria Inês P.S. Leitão; Maria Turos-Cabal; Ana Maria Sanchez-Sanchez; Clara Gomes; vanesa martin fernandez; Federico Herrera; Ana Petronilho. "Antitumor Activity and Reductive Stress by Platinum(II) N-Heterocyclic Carbenes based on Guanosine". 2022. https://doi.org/10.26434/chemrxiv-2022-k8c22. 10.26434/chemrxiv-2022-k8c22

Other

Other output

Development of Triazoles based on AZT and their Anti-Viral Activity Against HIV-1 (Pre-Print). 2019. Daniel Alencar; Juliana Goncalves; Sofia A. Cerqueira; Helena Soares; Ana Petronilho. Corresponding author: Ana Petronilho. https://doi.org/10.1101/523225.
10.1101/523225
Anti-proliferative Activity of N-Heterocyclic Carbenes Derived from Guanosine. 2018. Maria Inês Leitão; Federico Herrera; Ana Petronilho. https://doi.org/10.26434/chemrxiv.6022919.v1.
10.26434/chemrxiv.6022919.v1

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2023/09	N-Heterocyclic Carbenes Based on Uracil: Synthesis and Applications	XXV EuCHEMS Conference (Alcala de Henares, Spain)
2023/03/14	Some things Just Click: A journey trough Click Chemistry	XXVI Jornadas de Engenharia Quimica Instituto Superior Tecnico (Lisboa, Portugal)
2023/03/08	Mulheres na Ciência em Portugal	Encontros Universidade Senior USCQAL-Universidade Sénior de Carnaxide (Portugal)
2022/09	Playing with Metals: Exploring therapeutic profiles of nucleosides through metallation	2nd CoLIfe Meeting CoLife (Portugal)
2022/03	Nickel N-Heterocyclic Carbenes based on Xanthines: Synthesis and Antifungal Activity	13th Inorganic & Bioinorganic Chemistry Conference Universidade de Aveiro- Sociedade Portuguesa de Quimica (aveiro, Portugal)
2022/02	Exploiting synergies to enhance anticancer activity of metallodrugs	JORTEC 2022 FCT-CAPARICA (Caparica, Portugal)
2021/02/09	Exploiting Synergies For Enhancing Anticancer Activity: The Development of Metallated Nucleosides (Invited)	Conferencia IUPAC: Promoviendo la Diversidad Cultural en la Ciencia Universidad Juarez Autonoma de Tabasco (Mexico)
2020/12/12	Exploiting Synergies For Enhancing Anticancer Activity: The Development of Metallated Nucleosides (Invited)	Drug Discovery for Anti-Cancer Agents Symposium Faculty of Pharmacy, University Of Lisbon (Lisbon, Portugal)
2019/08/01	N-Heterocyclic Carbenes derived from mRNA cap analogs	9th International Symposium on Bioorganometallic Chemistry University of York (York, United Kingdom)
2019/06/26	N-Heterocyclic carbenes: From bioinspired catalysis to medicinal chemistry (Invited Plenary Lecture)	IX Encuentro de Química Inorganica Sociedad Quimica de México (Orizaba, Mexico)
2019/02	N-Heterocyclic Carbenes Formation in Nucleic Acids (Invited)	JORTEC2019 Faculdade de Ciências e Tecnologia-UNL (Monte da Caparica, Portugal)
2018/07/06	Guanine Based N-Heterocyclic Carbenes: syntesis and base pairing properties.	12th Inorganic Bioinorganic Chemistry Conference SPQ (Porto, Portugal)
2018/02	On the formation of N-heterocyclic Carbenes in Nucleosides	SCAN-ITQB-NOVA ITQB_NOVA (Oeiras, Portugal)
2017/11	Development of Novel AZT Derivatives Based on Triazoles	Jornadas Nova Saúde Universidade Nova de Lisboa (Lisbon, Portugal)
2017/10	Synthetic Approaches for N-Heterocyclic Carbenes Derived from DNA and RNA Adducts.	Department of Chemistry University of Bern (Switzerland)
2017/05	Base-Pairing Effects of N-Heterocyclic Carbene Formation in Nucleosides (Invited)	CHEMFORUM Instituto Superior Técnico (Lisbon, Portugal)
2016	Synthetic Methodologies for the Synthesis of N-Heterocyclic Carbenes Derived from Nucleosides	11th Inorganic Chemistry Conference Portuguese Chemical Society (Sintra, Portugal)
2015/09	Etherification of Carbonyl Compounds via Reductive Coupling Promoted by a Mesoionic Iridium Carbene Complex	International Symposium on Synthesis and Catalysis Universidade de Évora (Évora, Portugal)
2014/11	N-heterocyclic Carbenes: From Fundamental Chemistry to Extraordinary Applications	Chemistry Department University of Hull (Hull, United Kingdom)
2014/09	Oxidative Coupling: New Routes for Amide Bond Formation	SSPC Meeting University of Limerick (Limerick, Ireland)
2014/05	N-heterocyclic Carbenes: From Fundamental Chemistry to Extraordinary Applications	NUI-Maynooth NUI-Maynooth (Maynooth, Ireland)
2014	Iridium Cp* Complexes Based on Abnormal Carbenes: Synthesis, Reactivity and Catalysis	10th Inorganic Chemistry Conference Portuguese Chemical Society SPQ (Costa da Caparica, Portugal)
2013/07	Mesoionic Carbenes: Perfectly Abnormal	Interligações Químicas Departamento de Engenharia Química-IST (Lisbon, Portugal)
2013	Carbene Iridium Complexes as Catalysts for Water Oxidation	XXV International Conference in Organometalic Chemistry ICOMC (Lisbon, Portugal)
2012	Catalytic Water Oxidation Using Iridium Carbene Complexes	SFI-SEC: Solar Research Cluster Meeting Solar Research Cluster (Dublin, Ireland)
2011	Catalytic Water Oxidation Using Iridium Abnormal Carbene Complexes.	SFI-SEC: Solar Research Cluster Meeting Solar Research Cluster (Dublin, Ireland)
2009	Síntesis y reactividad de carbenos N-Heterocíclicos derivados de piridinas a-sustituídas	XXXII Bienal de la Real Sociedad Española de Química Real Sociedad Española de Quimica (Oviedo, Spain)
2008	Tautomerisation of N-Heterocycles by Ir(III) complexes	1st Portuguese Young Chemists Meeting SPQ (Lisbon, Portugal)
2008	Reactividad de carbenos N-Heterocíclicos derivados de piridinas	Reunión del Grupo Especializado en Química Organometállica GEQO-RSEQ (Santiago de Compostela, Spain)
2007	Reactividad de carbenos N-Heterocíclicos derivados de piridinas	Consolider-Orfeo Meeting Consolider (Ciudad Real, Spain)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2021/07/15 - 2025	Targeting Metallodrug Delivery Through Encapsulation (PhD supervisor) Supervisor of Giulia Orsini	Chemistry (PhD) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2019/10/01 - 2023/09/30	Novel Tools to Target DNA adducts (PhD supervisor) Supervisor of Giulia Franscescato	Chemistry (PhD)
2018/01/01 - 2022/09/30	Synthesis of Platinum and Palladium complexes bearing N-Heterocyclic Carbenes based on nucleosides and their anticancer activity Supervisor of Maria Inês Paiva SIlva Leitão-PD/BD/135483	PhD Molecular Biosciences (PhD) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2017/04 - 2022/01/16	Exploring the synergy between copper loading and antifungals (PhD-co-supervisor) Co-supervisor of Ana Carolina Cordeiro	PhD Molecular Biosciences (PhD) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2021/03 - 2021/06	Síntese de compostos derivados de AZT para aplicação no combate ao vírus da SIDA Supervisor of Rafaela Cordeiro	Bioquimica (Degree) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2019/01/02 - 2019/09/30	Synthesis of Nickel complexes bearing N-Heterocyclic carbenes derived from nucleosides. (Erasmus + Supervision- Master) Supervisor of Giulia Francescato	Erasmus + Intership (Other) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal Università degli Studi di Pavia, Italy
2018/01/01 - 2018/06/30	Synthesis of metal complexes stabilized by nucleobase adducts (Erasmus + Internship- master) Supervisor of Zuzanna Filipiak	Erasmus + internship (Other) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal Roskilde Universitet, Denmark
2017/09/15 - 2018/06/30	NOVEL AZT-TRIAZOLES FOR HIV STRAINS (Erasmus interniship) Supervisor of Daniel Machado de Alencar	Erasmus + Intership (Other) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal University of Bath, United Kingdom
2018/01/02 - 2018/03/30	Synthesis of N-Heterocyclic carbenes derived from adenine. (Erasmus internship) Supervisor of Manuel Hernandez	Erasmus + intership (Other) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal Universidad de Murcia, Spain
2016/09/15 - 2017/11/30	Rethinking Triazoles as Antifungals: Synthesis and Evaluation of New Triazole Derivatives (Master Thesis Supervision) Supervisor of Andreia Vieira	Biochemistry for Health (Master) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2016/10 - 2017/08	Synthesis of Nickel complexes bearing N-Heterocyclic carbenes derived from caffeine (Erasmus internship) Supervisor of Nicolaus Giannopoulos	Erasmus + intership (Other) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal National and Kapodistrian University of Athens, Greece
2016/10/17 - 2017/07/17	Synthesis of metal complexes stabilized by nucleobase adducts (Erasmus internship) Supervisor of Carmen Gonzalez	Erasmus Internship (Other) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal Universidad de Huelva, Spain
2017/01/01 - 2017/04/30	Synthesis of Triazoles based on Zidovudine (Erasmus Internship) Supervisor of Paola Antenori	Erasmus+ Intership (Other) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Event organisation

	Event name Type of event (Role)	Institution / Organization
2019/05/14 - 2019/05/16	Erasmus TransPeer Workshop: Science Policy and Leadership (2019/05/14 - 2019/05/16) Workshop (Co-organisor)

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2022/07/12	Diseño y Aplicación de Arquitecturas Rh-NHC en Reacciones Cataliticas de Hydrofunctionalizacion de Alquinos (Thesis) Main arguer	MAria Galiana Cameo (PhD) Universidad de Zaragoza, Spain
2021/04/02	Supramolecular Catalytic Systems: Synthesis, Characterization and Application in Catalysis (Thesis) Arguer	Ester Iniesta (PhD) Universitat Autònoma de Barcelona, Spain
2021/01/22	THE SYNTHESIS AND EVALUATION OF BIS-1,2,3-TRIAZOLYLIDENE(CARBAZOLIDE) GOLD COMPLEXES AS ANTICANCER AGENTS (Thesis) Arguer	Danielle van der Westhuizen (PhD) University of the Witwatersrand, South Africa
2019/12/20	Towards Cooperative Organometallic and Enzymatic Catalysis to Develop New Value Chains from Organic Wastes (Thesis) Arguer	Ana Fernandes (PhD) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2019/08/08	Compuestos organomet licos en reacciones de acoplamiento deshidrogenante, transformacion del dioxido de carbono y otros procesos cataliticos (External Evaluator) (Thesis) Arguer	Pablo Rios (PhD) Universidad de Sevilla, Spain
2018/12/12	Synthesis, reactivity and computational studies of Ir complexes bearing terphenyl phosphine ligands (External Evaluator) (Thesis) Arguer	Juan Manuel Moreno (PhD) Universidad de Sevilla, Spain
2017/06/16	PhD Thesis Evaluation of Carmen Mejuto University Jaume I Spain (Thesis) Main arguer	Carmen Mejuto (PhD) Universitat Jaume I, Spain
2015/09	Late Transition Metal Organometallic Chemistry. Rhodium, Iridium and Gold Complexes with s and p Hydrocarbon-Based Ligands (External Evaluator)	Maria Rodriguez (PhD) Universidad de Sevilla, Spain
2015	Scientific Evaluator (PhD Thesis) Angela Vivancos (Thesis) Main arguer	Angela Vivancos (PhD) Universidad de Sevilla, Spain
2013	Transition metal complexes bearing 5- and 6-membered N-heterocyclic carbene ligands. Synthesis and reactivity studies (External Evaluator)	Marta Roselló (PhD) Universidad de Sevilla, Spain

Committee member

	Activity description Role	Institution / Organization
2019/09/01 - Current	Coordinator of Gender Equality Working Group of ITQB NOVA Coordinator	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2019/05/01 - Current	ACT ON GENDER - Community of Practices -Life Sciences https://www.act-on-gender.eu/ Member
2018/01/01 - Current	Thesis Commission Member-Diana Silva Advisor / Consultant
2018/01/01 - Current	Thesis commission PhD-Marcia Renio Advisor / Consultant	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2017/01/01 - Current	Thesis Commission Member João Cascão Advisor / Consultant	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2016 - Current	Member of Scientific Council ITQB-NOVA Member	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2016 - 2019	Thesis Commission Member - Mara Pinto Advisor / Consultant

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2019/10/01 - Current	Research Training I of the Molecular Biosciences (Unit Coordinator)	(Doutoramento)	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2019/11/29 - 2019/11/29	Click Chemistry for Bioconjugation, within the discipline Biological Chemistry	Click Chemistry for Bioconjugation (Doutoramento)	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2018/06 - 2018/06	Biological Chemistry	PhD Programme in Sustainable Chemistry (Curso de doutoramento (conclusão de unidades curriculares))	Universidade Nova de Lisboa, Portugal

Evaluation committee

	Activity description Role	Institution / Organization	Funding entity
2023/03 - Current	Evaluation of Research projects-SONATA GRANTS Evaluator	Narodowe Centrum Nauki, Poland

Interview (tv / radio show)

	Program	Topic
2019/07/08 - 2019/07/08	90 segundos de Ciência

Distinctions

Other distinction

2020	CEEC Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2014	SFI Fellowship Science Foundation Ireland, Ireland
2014	Investigador FCT-Starting Fundação para a Ciência e a Tecnologia, Portugal
2010	Postdoctoral Fellowship
2010	UNED grant
2006	BD-Fellowship