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Identification

Personal identification

Full name
Vera Ribeiro Marques
Gender
Female

Citation names

  • Marques, Vera
  • Ribeiro, V

Author identifiers

Ciência ID
3411-732A-B7FB
ORCID iD
0000-0002-9697-7830
Google Scholar ID
https://scholar.google.pt/citations?user=SvseyEcAAAAJ&hl=pt-PT
Researcher Id
G-3783-2011
Scopus Author Id
7006349364

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Intermediate (B1) Advanced (C1) Intermediate (B1) Intermediate (B1)
Italian Beginner (A1) Intermediate (B1) Beginner (A1) Beginner (A1)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Beginner (A1) Intermediate (B1)
Education
Degree Classification
1994
Concluded
 Doutoramento em Bioquímica - Biologia Molecular (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Expression and regulation of CYP3A genes. Cloning and characterization of a CYP3A1 allelic variant" (THESIS/DISSERTATION)
 Distinção e Louvor
1987
Concluded
 Química-Ramo de Bioquímica (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Isolation of Cytochromes P450 from rat liver by affinity chromatography. Immunochemical detection in hepatocytes in different physiological states" (THESIS/DISSERTATION)
 16/20
Affiliation

Science

Category
Host institution 		Employer
2015 - Current Principal Investigator (Research) Centro de Ciências do Mar, Portugal
2013 - 2015 Principal Investigator (Research) Universidade do Algarve Centro de Investigação em Biomedicina, Portugal
2003 - 2015 Coordinating Researcher (Research) Centro de Biomedicina Molecular e Estrutural, Portugal
1997/01/01 - 2000/10/01 Researcher (Research) Faculdade de Farmácia Universidade de Lisboa, UID 452 Biologia Molecular, Genética Ambiental e Farmacogenética , Portugal

Teaching in Higher Education

Category
Host institution 		Employer
1999/10/04 - Current Assistant Professor (University Teacher) Universidade do Algarve, Portugal
1998/10/04 - 1999/10/04 Invited Assistant Professor (University Teacher) Universidade do Algarve, Portugal

Positions / Appointments

Category
Host institution 		Employer
2017 - 2018 Conselho científico/técnico-científico ou orgão correspondente Universidade do Algarve, Portugal
2013 - 2015 Conselho científico/técnico-científico ou orgão correspondente Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal

Others

Category
Host institution 		Employer
2005 - 2005 Invited Professor (“Maitre de Conferences Invité”) INSERM UMR-S747 (Pharmacologie, Toxicologie et Signalisation Cellulaire), Faculté de Médecine, Université René Descartes, Paris V, France
2003 - 2003 Invited Professor (“Maitre de Conferences Invité”) Université de Nancy 1 Faculté de Pharmacie de Nancy, France
2002 - 2002 Visiting Professor Karolinska Universitetssjukhuset, Sweden
Outputs

Publications

Journal article
  1. Mulata Haile Nega; Derbew Fikadu Berhe; Vera Ribeiro. "Pharmacogenetic analysis of inter-ethnic variability in the uptake transporter SLCO1B1 gene in Colombian, Mozambican, and Portuguese populations". BMC Medical Genomics (2023): http://dx.doi.org/10.1186/s12920-023-01642-4.
    10.1186/s12920-023-01642-4
  2. Jorge C. Correia; Julie Massart; Jan Freark de Boer; Margareta Porsmyr-Palmertz; Vicente Martínez-Redondo; Leandro Z. Agudelo; Indranil Sinha; et al. "Bioenergetic cues shift FXR splicing towards FXRa2 to modulate hepatic lipolysis and fatty acid metabolism". Molecular Metabolism 4 12 (2015): 891-902. https://doi.org/10.1016%2Fj.molmet.2015.09.005.
    10.1016/j.molmet.2015.09.005
  3. Parente Carvalho, Catia; Norouzy, Amir; Ribeiro, Vera; Nau, Werner M.; Pischel, Uwe. "Cucurbiturils as supramolecular inhibitors of DNA restriction by type II endonucleases". Organic & Biomolecular Chemistry 13 10 (2015): 2866-2869. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000350674400003&KeyUID=WOS:000350674400003.
    10.1039/c4ob02122c
  4. Butenko, N.; Pinheiro, J.P.; Da Silva, J.P.; Tomaz, A.I.; Correia, I.; Ribeiro, V.; Costa Pessoa, J.; Cavaco, I.. "The effect of phosphate on the nuclease activity of vanadium compounds". Journal of Inorganic Biochemistry 147 (2014): 165-176. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930869864&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2015.04.010
  5. Ribeiro, A.L.; Ribeiro, V.. "Drug metabolism and transport under hypoxia". Current Drug Metabolism 14 9 (2013): 969-975. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887917442&partnerID=MN8TOARS.
    10.2174/1389200211314090003
  6. Ribeiro, A.L.; Gaspar, J.F.; Pereira, T.; Ribeiro, V.. "Lack of relevance of HIF-1a polymorphisms in breast cancer in a portuguese population". Anticancer Research 33 6 (2013): 2549-2556. http://www.scopus.com/inward/record.url?eid=2-s2.0-84881366858&partnerID=MN8TOARS.
  7. Dias, V.; Ribeiro, V.. "Ethnic differences in the prevalence of polymorphisms in CYP7A1, CYP7B1 and CYP27A1 enzymes involved in cholesterol metabolism". Journal of Pharmacy and Bioallied Sciences 3 3 (2011): 453-459. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052760752&partnerID=MN8TOARS.
    10.4103/0975-7406.84465
  8. Félix, R.C.; Müller, P.; Ribeiro, V.; Ranson, H.; Silveira, H.. "Plasmodium infection alters Anopheles gambiae detoxification gene expression". BMC Genomics 11 1 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77952304778&partnerID=MN8TOARS.
    10.1186/1471-2164-11-312
  9. Teixeira, V.H.; Ribeiro Vera, V.; Martel, P.J.. "Analysis of binding modes of ligands to multiple conformations of CYP3A4". Biochimica et Biophysica Acta - Proteins and Proteomics 1804 10 (2010): 2036-2045. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956060951&partnerID=MN8TOARS.
    10.1016/j.bbapap.2010.06.008
  10. Ribeiro, A.L.; Correia, J.; Ribeiro, V.. "Ethnic variability of HIF-1a polymorphisms". Cancer Biomarkers 5 6 (2009): 273-277. http://www.scopus.com/inward/record.url?eid=2-s2.0-76749153450&partnerID=MN8TOARS.
    10.3233/CBM-2009-0112
  11. Veiga, M.I.; Asimus, S.; Ferreira, P.E.; Martins, J.P.; Cavaco, I.; Ribeiro, V.; Hai, T.N.; et al. "Pharmacogenomics of CYP2A6, CYP2B6, CYP2C19, CYP2D6, CYP3A4, CYP3A5 and MDR1 in Vietnam". European Journal of Clinical Pharmacology 65 4 (2009): 355-363. http://www.scopus.com/inward/record.url?eid=2-s2.0-62549099045&partnerID=MN8TOARS.
    10.1007/s00228-008-0573-8
  12. Butenko, N.; Tomaz, A.I.; Nouri, O.; Escribano, E.; Moreno, V.; Gama, S.; Ribeiro, V.; et al. "DNA cleavage activity of VIVO(acac)2 and derivatives". Journal of Inorganic Biochemistry 103 4 (2009): 622-632. http://www.scopus.com/inward/record.url?eid=2-s2.0-62349111293&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2009.01.003
  13. Ferreira, P.E.; Veiga, M.I.; Cavaco, I.; Martins, J.P.; Andersson, B.; Mushin, S.; Ali, A.S.; et al. "Polymorphism of antimalaria drug metabolizing, nuclear receptor, and drug transport genes among malaria patients in Zanzibar, east Africa". Therapeutic Drug Monitoring 30 1 (2008): 10-15. http://www.scopus.com/inward/record.url?eid=2-s2.0-38549176303&partnerID=MN8TOARS.
    10.1097/FTD.0b013e31815e93c6
  14. Dorado, P.; Cavaco, I.; Cáceres, M.C.; Piedade, R.; Ribeiro, V.; LLerena, A.. "Relationship between CYP2C8 genotypes and diclofenac 5-hydroxylation in healthy Spanish volunteers". European Journal of Clinical Pharmacology 64 10 (2008): 967-970. http://www.scopus.com/inward/record.url?eid=2-s2.0-53249103537&partnerID=MN8TOARS.
    10.1007/s00228-008-0508-4
  15. Cavaco, I.; Asimus, S.; Peyrard-Janvid, M.; Ferreira, P.E.; Veiga, M.I.; Hai, T.N.; Ribeiro, V.; Ashton, M.; Gil, J.P.. "The Vietnamese khin population harbors particular N-acetyltransferase 2 allele frequencies [2]". Clinical Chemistry 53 11 (2007): 1977-1979. http://www.scopus.com/inward/record.url?eid=2-s2.0-35649010335&partnerID=MN8TOARS.
    10.1373/clinchem.2007.092684
  16. Pessoa, J.C.; Cavaco, I.; Correia, I.; Tomaz, I.; Adão, P.; Vale, I.; Ribeiro, V.; Castro, M.M.C.A.; Geraldes, C.C.F.G.. "Vanadium schiff base complexes: Chemistry, properties, and concerns about possible therapeutic applications". ACS Symposium Series 974 (2007): 340-351. http://www.scopus.com/inward/record.url?eid=2-s2.0-36749027238&partnerID=MN8TOARS.
  17. Jeannesson, E.; Albertini, L.; Siest, G.; Gomes, A.-M.; Ribeiro, V.; Aslanidis, C.; Schmitz, G.; Visvikis-Siest, S.. "Determination of ABCB1 polymorphisms and haplotypes frequencies in a French population". Fundamental and Clinical Pharmacology 21 4 (2007): 411-418. http://www.scopus.com/inward/record.url?eid=2-s2.0-34447515970&partnerID=MN8TOARS.
    10.1111/j.1472-8206.2007.00507.x
  18. Dias, V.; Ribeiro, V.. "The expression of the solute carriers NTCP and OCT-1 is regulated by cholesterol in HepG2 cells". Fundamental and Clinical Pharmacology 21 4 (2007): 445-450. http://www.scopus.com/inward/record.url?eid=2-s2.0-34447540370&partnerID=MN8TOARS.
    10.1111/j.1472-8206.2007.00517.x
  19. Cavaco, I.; Piedade, R.; Gil, J.P.; Ribeiro, V.. "CYP2C8 polymorphism among the Portuguese". Clinical Chemistry and Laboratory Medicine 44 2 (2006): 168-170. http://www.scopus.com/inward/record.url?eid=2-s2.0-32544457394&partnerID=MN8TOARS.
    10.1515/CCLM.2006.030
  20. Ribeiro, V.; Cavaco, I.. "Pharmacogenetics of cytochromes P450 in tropical medicine". Current Drug Targets 7 12 (2006): 1709-1719. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845306250&partnerID=MN8TOARS.
    10.2174/138945006779025347
  21. Cavaco, I.; Strömberg-Nörklit, J.; Kaneko, A.; Msellem, M.I.; Dahoma, M.; Ribeiro, V.L.; Bjorkman, A.; Gil, J.P.. "CYP2C8 polymorphism frequencies among malaria patients in Zanzibar". European Journal of Clinical Pharmacology 61 1 (2005): 15-18. http://www.scopus.com/inward/record.url?eid=2-s2.0-17644419314&partnerID=MN8TOARS.
    10.1007/s00228-004-0871-8
  22. Rodrigues, E.; Vilarem, M.-J.; Ribeiro, V.; Maurel, P.; Lechner, M.C.. "Two CCAAT/enhancer binding protein sites in the cytochrome p4503A1 locus: Potencial role in the glucocorticoid response". European Journal of Biochemistry 270 3 (2003): 556-564. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037315606&partnerID=MN8TOARS.
    10.1046/j.1432-1033.2003.03413.x
  23. Cavaco, I.; Gil, J.P.; Gil-Berglund, E.; Ribeiro, V.. "CYP3A4 and MDR1 alleles in a Portuguese population". Clinical Chemistry and Laboratory Medicine 41 10 (2003): 1345-1350. http://www.scopus.com/inward/record.url?eid=2-s2.0-0142091684&partnerID=MN8TOARS.
    10.1515/CCLM.2003.206
  24. Marques, L.P.J.; Cavaco, I.; Pinheiro, J.P.; Ribeiro, V.; Ferreira, G.N.M.. "Electrochemical DNA sensor for detection of single nucleotide polymorphisms". Clinical Chemistry and Laboratory Medicine 41 4 (2003): 475-481. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038397433&partnerID=MN8TOARS.
    10.1515/CCLM.2003.071
  25. Cavaco, I.; Reis, R.; Gil, J.P.; Ribeiro, V.. "CYP3A4*1B and NAT2*14 alleles in a native African population". Clinical Chemistry and Laboratory Medicine 41 4 (2003): 606-609. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037721320&partnerID=MN8TOARS.
    10.1515/CCLM.2003.091
  26. Fisher, M.B.; Thompson, S.J.; Ribeiro, V.; Lechner, M.C.; Rettie, A.E.. "P450-catalyzed in-chain desaturation of valproic acid: Isoform selectivity and mechanism of formation of d3-valproic acid generated by baculovirus-expressed CYP3A1". Archives of Biochemistry and Biophysics 356 1 (1998): 63-70. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032147090&partnerID=MN8TOARS.
    10.1006/abbi.1998.0742
  27. Wright, M.C.; Edwards, R.J.; Pimenta, M.; Ribeiro, V.; Ratra, G.S.; Lechner, M.C.; Paine, A.J.. "Developmental changes in the constitutive and inducible expression of cytochrome P450 3A2". Biochemical Pharmacology 54 7 (1997): 841-846. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030859375&partnerID=MN8TOARS.
    10.1016/S0006-2952(97)00264-5
  28. Wright, M.C.; Wang, X.-J.; Pimenta, M.; Ribeiro, V.; Paine, A.J.; Lechner, M.C.. "Glucocorticoid receptor-independent transcriptional induction of cytochrome P450 3A1 by metyrapone and its potentiation by glucocorticoid". Molecular Pharmacology 50 4 (1996): 856-863. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029909703&partnerID=MN8TOARS.
  29. Leandro, P.; Rivera, I.; Ribeiro, V.; De Almeida, I.T.; Da Silveira, C.; Lechner, M.C.. "Mutation analysis of phenylketonuria in South and Central Portugal: Prevalence of V388M mutation". Human Mutation 6 2 (1995): 192-194. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029102923&partnerID=MN8TOARS.
    10.1002/humu.1380060217
  30. Ribeiro, V.; Lechner, M.C.. "Cloning and characterization of a novel CYP3A1 allelic variant: Analysis of CYP3A1 and CYP3A2 sex-hormone-dependent expression reveals that the CYP3A2 gene is regulated by testosterone". Archives of Biochemistry and Biophysics 293 1 (1992): 147-152. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026573342&partnerID=MN8TOARS.
    10.1016/0003-9861(92)90377-9
  31. Chasserot-Golaz, S.; Ribeiro, V.; Genot, G.; Lechner, M.C.; Beck, G.. "The steroid antagonist RU38486 is metabolized by the liver microsomal P450 mono-oxygenases". Biochemical and Biophysical Research Communications 167 3 (1990): 1271-1278. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025327396&partnerID=MN8TOARS.
    10.1016/0006-291X(90)90661-6
  32. Lechner, M.C.; Ribeiro, V.L.; Henrique, D.; Barroso, M.; Cravino, M.M.. "Modulation of mRNAs P450 during promotion of hepatocarcinogenesis | MODULATION DES MRNAS P450 ET PROMOTION DE L'HEPATOCANCEROGENESE". Bulletin du Cancer 77 5 (1990): 509-514. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025359188&partnerID=MN8TOARS.
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2024 - Current Biomarcadores farmacogenómicos como fonte de evidência para a efetividade e segurança dos anti-coagulantes.
Co-supervisor of Filipa Isabel Coelho da Luz Barradas
 Pharmaceutical Sciences (Master)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2023 - 2023 Terapia génica pré-natal: Evolução e perspetivas futuras.
Supervisor of Carolina Jorge Veiga
 Integrated Master in Pharmaceutical sciences (Master)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2021 - 2021 Farmacogenómica do Mieloma Múltiplo.
Supervisor of Susana Daniela Ferraz de Noronha e Vasconcelos
 Integrated Master in Pharmaceutical Sciences (Master)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2021 - 2021 Fatores de suscetibilidade genética para a hipertensão arterial: a via de sinalização pelo recetor de hidrocarbonetos aromáticos.
Supervisor of CRISTIANO JOSÉ DA SILVA SALES
 Integrated Master in Pharmaceutical Sciences (Master)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2018 - 2018 Tumores cerebrais - histopatologia e tratamento de gliomas
Co-supervisor
 Ciências Farmacêuticas (Master)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2018 - 2018 A farmacogenómica na terapêutica das dislipidemias Ciências Farmacêuticas (Master)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2018 - 2018 Tumores Cerebrais – Histopatologia e Tratamento de Glioblastomas
Co-supervisor of Susana Filipa Jordão Viegas
 Integrated Master in Pharmaceutical Sciences (Master)
Universidade do Algarve - Campus de Gambelas, Portugal
2017 - 2017 A deficiência no enzima Glicose-6-Fosfato Desidrogenase - sensibilidade a fármacos
Supervisor
 Ciências Farmacêuticas (Master)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2017 - 2017 Fatores que influenciam o risco de desenvolvimento de cancro do pulmão
Supervisor
 Ciências Farmacêuticas (Master)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2017 - 2017 Influência da farmacogenómica na terapêutica da artrite reumatóide
Supervisor
 Ciências Farmacêuticas (Master)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2016 - 2016 A evolução da terapêutica com anticoagulantes orais: papel da farmacogenómica na avaliação da segurança
Supervisor
 Ciências Farmacêuticas (Master)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2015 - 2015 PHARMACOGENETIC ANALYSIS OF THE PREGNANE X RECEPTOR IN A BREAST CANCER CASE-CONTROL STUDY Qualidade em Análises (Master)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2014 - 2014 A IMPORTÂNCIA DA FARMACOGENÓMICA NA TERAPÊUTICA DA DIABETES MELLITUS TIPO 2 E DE COMORBILIDADES ASOCIADAS (HIPERTENSÃO E DISLIPIDEMIA) Ciências Farmacêuticas (Master)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2013 - 2013 DOENÇAS CARDIOVASCULARES: METABOLITOS DO CITOCROMO P 450 DA VIA DO ÁCIDO ARAQUIDÓNICO NO CONTROLO DO TÓNUS VASCULAR Ciências Farmacêuticas (Master)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2009 - 2009 TRANSCRIPTIONAL CONTROL OF ENERGY METABOLISM: STUDIES ON FXR AND PGC-1 Ciências Biológicas (PhD)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2008 - 2008 Molecular Determinants of the Response to Malaria Therapeutics Química (PhD)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2006 - 2006 Primary Production in Systems Subject to Natural and Anthropogenic Eutrophication
Co-supervisor
 Química (PhD)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2006 - 2006 NUCLEAR RECEPTOR SIGNALLING PATHWAYS IN CARDIOVASCULAR DISEASE: EXPRESSION PROFILE AND PHARMACOGENETICS OF GENES CANDIDATE TO PLAY A ROLE IN CARDIOVASCULAR DISEASE Ciências Biológicas (PhD)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2006 - 2006 The Role of hypoxia in the regulationof membrane transporters Ciências Biológicas (PhD)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2005 - 2005 Role of Drugmetabolism in Antimalarial Resistence Ciências Biológicas (PhD)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2023 - 2023 Membro do Painel de Peritos no Concurso para Atribuição de Bolsas de Investigação para Doutoramento 2023, no painel de Biologia Experimental e Bioquímica
Evaluator
 Fundação para a Ciência e a Tecnologia, Portugal
2020/07 - 2020/11 Membro do Painel de Peritos no Concurso para Atribuição de Bolsas de Investigação para Doutoramento 2020, no painel de Biologia Experimental e Bioquímica.
Evaluator
 Fundação para a Ciência e a Tecnologia, Portugal Fundação para a Ciência e a Tecnologia
2019/05 - 2019/10 Membro do Painel de Peritos no Concurso para Atribuição de Bolsas de Investigação para Doutoramento 2019, no painel de Biologia Experimental e Bioquímica.
Evaluator
 Fundação para a Ciência e a Tecnologia, Portugal Fundação para a Ciência e a Tecnologia
Distinctions

Other distinction

2007 Prémio Ceratonia para o Projecto “Determinantes moleculares da falência da terapêutica da Malária em Angola”
2007 Programa Empreender+, Call for Ideas for spin-offs of research and development.
2004 Membro da equipa premiada no Concurso de Idéias para a Criação de Empresas - Universidade do Algarve