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Identification

Personal identification

Full name
Jéssica Lopes Nunes

Citation names

  • Lopes-Nunes, Jéssica

Author identifiers

Ciência ID
6517-C3F7-6171
ORCID iD
0000-0001-9853-0306

Addresses

  • Health Sciences Research Centre, Faculty of Health Sciences, University of Beira Interior, Covilhã, Portugal. Av. Infante D. Henrique, 6200-506 , Covilhã, Covilhã, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Intermediate (B1) Upper intermediate (B2) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
2024
Ongoing
 Biomedicina (Doutoramento)
Universidade da Beira Interior, Portugal
2018/10/01 - 2018/11/19
Concluded
 Curso para el Desempeño de las Funciones B, C y D en Roedores, Lagomorfos, Carnívoros, Cerdos y Pequeños Rumiantes (Outros)
Centro de Cirugía de Mínima Invasión Jesús Usón, Spain
2017/09/18 - 2017/09/22
Concluded
 III Quantitative Fluorescence Microscopy Course (Outros)
CNC.IBILI, Portugal
2015/09 - 2017/07/26
Concluded
 Ciências Biomédicas (Mestrado)
Universidade da Beira Interior, Portugal
"Novel transcriptional regulation mechanisms associated with Parkinson’s disease pathogenesis: from biological activity towards therapy" (THESIS/DISSERTATION)
 18
2012/09 - 2015/07/01
Concluded
 Ciências Biomédicas (Licenciatura)
Universidade da Beira Interior, Portugal
"n/a" (THESIS/DISSERTATION)
 15
Affiliation

Science

Category
Host institution 		Employer
2024/03/04 - 2024/03/15 Visiting Researcher (Research) Universitair Medisch Centrum Groningen, Netherlands
2022/03/28 - 2022/04/15 Visiting Researcher (Research) Università degli Studi di Ferrara, Italy
Università degli Studi di Ferrara, Italy
2019/10/01 - 2019/10/15 Visiting Researcher (Research) Universidad Autónoma de Madrid Facultad de Medicina, Spain
Universidad Autónoma de Madrid, Spain
2019/05/13 - 2019/05/17 Visiting Researcher (Research) Centro de Ciências e Tecnologias Nucleares, Portugal
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
2018/11/15 - 2019/01/03 Researcher (Research) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2016/06 - 2017/07 Researcher (Research) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal

Others

Category
Host institution 		Employer
2020/11/01 - 2024/10/31 PhD Fellowship (ref. 2020.05329.BD) Fundação para a Ciência e a Tecnologia, Portugal, Portugal
2019/01/04 - 2020/11/03 Research Fellow - DREAM project (ref. UTAP-EXPL/NTec/0015/2017) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2018/01/03 - 2018/11/02 Research fellow (BID/ICI-FCS/CICS/Santander Universidades-UBI/2017) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Projects

Grant

Designation Funders
2019/01/04 - 2020/10/30 Drug delivery nanosystem for HPV infection therapy - DREAM
UTAP-EXPL/NTec/0015/2017
Research Fellow
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

University of Texas at Austin, United States

Centro Hospitalar Cova da Beira EPE, Portugal

Health Products Research and Development Lda, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing

Other

Designation Funders
2024/09/26 - Current AquaClean – Monitorização e remoção de disruptores endócrinos em águas superficiais
PL24-00059
Researcher
Universidade da Beira Interior FibEnTech Materiais Fibrosos e Tecnologias Ambientais, Portugal

Agência Portuguesa do Ambiente, Portugal

Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Fundação para a Ciência e a Tecnologia

Fundação La Caixa
Ongoing
2023 - Current DEFEND - Gel vaginal para lesões cancerígenas causadas pelo vírus do Papiloma Humano
CENTRO-01-0246-FEDER-000044
Researcher
Universidade da Beira Interior, Portugal
 INOVC+ Ecossistema de Inovação Inteligente da Região Centro funded by CENTRO 2020
Ongoing
2022 - Current Vaginal gel for topical application in precancerous lesions caused by the HPV
CENTRO-45-2021-30
Researcher
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal

Health Products Research and Development Lda, Portugal
Comissão de Coordenação e Desenvolvimento Regional do Centro
2021 - Current COMBINE - CombinatiOn aptaMer-drug Based therapeutics for ocular neovascular dIsease wheN two are bettEr than one
BInov
Researcher
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
 Ordem dos Farmaceuticos
2020 - 2021 SENSE - Deteção de eStruturas de G-quadruplEx no SARS-CoV-2 utilizando soNdas fluorescentes
ref. 6
Researcher
Centro de Competências em Cloud Computing (C4)
Concluded
2020/05/25 - 2020/08/24 Track and Trace COVID-19
149_596826219
Researcher
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2019/01/01 - 2019/12/31 Projeto de I&D do Plano Estratégico do Centro de Investigação em Ciências da Saúde - CICS
UID/Multi/00709/2019
Researcher
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
Outputs

Publications

Conference abstract
  1. Lopes-Nunes, Jéssica; Nastruzzi, Claudio; Cruz, Carla. "Production of aptamer-guided liposomes for head and neck cancer treatment". Paper presented in 2nd CA17140 STSM Virtual Conference, 2023.
    10.18778/costaction17140
  2. Lopes-Nunes, Jéssica; Oliveira, Paula A.; Cruz, Carla. "Development and Evaluation of AT11-Guided Liposomes for Human Papillomavirus Cancer". Paper presented in 8th International Electronic Conference on Medicinal Chemistry, 2022.
    10.3390/ecmc2022-13410
  3. Lopes-Nunes, Jéssica; Lifante, José; Shen, Yingli; Ximendes, Erving C; Iglesias-de la Cruz, M. Carmen; Jaque, Daniel; Cruz, Carla. "ICG-tagged aptamer as drug delivery system for malignant melanoma". Paper presented in Cost Action 17140, 1st STMS Virtual Conference, 2022.
    10.18778/costaction
  4. Nunes, Jéssica; Cruz, Carla; Oliveira, Paula. "Development of novel aptamer-functionalized liposomes for oral cancer therapy". Paper presented in 7th International Electronic Conference on Medicinal Chemistry, 2021.
    10.3390/ecmc2021-11516
Conference poster
  1. Lopes-Nunes, Jéssica; Oliveira, Paula A; Cruz, Carla. "LIPOSSOMAS GUIADOS POR APTAMEROS PARA LESÕES RELACIONADAS COM O VÍRUS DO PAPILOMA HUMANO". Paper presented in X Ciclo de Conferências da Faculdade de Ciências, 2024.
  2. Moreira, David; Leitão, Daniela; Lopes-Nunes, Jéssica; Santos, Tiago; Figueiredo, Joana; Miranda, André; Alexandre, Daniela; et al. "DECODING AT11-L2: G-QUADRUPLEX STRUCTURE, STABILITY, AND INTERACTION WITH LIGANDS AND NUCLEOLIN". Paper presented in XVIII International CICS-UBI Symposium, 2023.
  3. Lopes-Nunes, Jéssica; Oliveira, Paula A; Cruz, Carla. "APTAMER-GUIDED LIPOSOMES FOR ORAL CANCER TREATMENT". Paper presented in XVIII International CICS-UBI Symposium, 2023.
  4. Cruz, Carla; Lopes-Nunes, Jéssica; Oliveira, Paula. "AT11-GUIDED LIPOSOMES FOR HUMAN PAPILLOMA VIRUS CANCER: DEVELOPMENT AND CHARACTERIZATION OF A NOVEL APPROACH". Paper presented in 35th International Papillomavirus Conference, 2023.
  5. Cruz, Carla; Lopes-Nunes, Jéssica; Maocha, Izamara. "DEVELOPMENT OF GEL FORMULATION FOR HUMAN PAPILLOMAVIRUS-INDUCED LESIONS". Paper presented in 35th International Papillomavirus Conference, 2023.
  6. Cruz, Carla; Lopes-Nunes, Jéssica; Simões, Pedro. "RNA-GUIDED NANOPARTICLES FOR ORAL CANCER THERAPY". Paper presented in 35th International Papillomavirus Conference, 2023.
  7. Lopes-Nunes, Jéssica; Oliveira, Paula A; Cruz, Carla. "Production and evaluation of aptamer-functionalized liposomes for oral cancer therapy". Paper presented in XV Jornadas de Genética e Biotecnologia e V Jornadas Ibéricas de Genética y Biotecnología, 2023.
  8. Lopes-Nunes, Jéssica; Oliveira, Paula A; Cruz, Carla. "Aptamer-Functionalized Gold Nanoparticles for Drug Delivery to Gynecological Cancer Cells". Paper presented in INTERACTION WINS 2023 (virtual), 2023.
  9. Moreira, David; Leitão, Daniela; Lopes-Nunes, Jéssica; Santos, Tiago; Figueiredo, Joana; Miranda, André; Alexandre, Daniela; et al. "G-quadruplex aptamer interactions with ligands and nucleolin". Paper presented in INTERACTION WINS 2023 (virtual), 2023.
  10. Miranda, André; Lopez-Blanco, Roi; Lopes-Nunes, Jéssica; Melo, Ana M.; Cabral Campello, Maria Paula; Paulo, António; Oliveira, Maria Cristina; et al. "Gallic acid-triethylene glycol aptadendrimers synthesis, biophysical characterization and cellular evaluation". Paper presented in DARTER COST Final Meeting, 2023.
  11. Lopes-Nunes, Jéssica; Oliveira, Paula A; Cruz, Carla. "AT11-GUIDED LIPOSOMES AS POTENTIAL THERAPEUTIC APPROACH FOR HUMAN PAPILLOMA VIRUS-ASSOCIATED ORAL CANCER". Paper presented in IV International Congress on Health Sciences Research Towards Innovation and Entrepreneurship - Challenges from Research to Clinic, 2023.
  12. Rosado, Beatriz; Maocha, Izamara; Lopes-Nunes, Jéssica; Lopes, Melanie; Rolo, Joana; Palmeira-de-Oliveira, Ana; Palmeira-de-Oliveira, Rita; Martinez-de-Oliveira, José; Cruz, Carla. "DEVELOPMENT OF A VAGINAL GEL FOR TREATMENT OF INTRAEPITHELIAL LESIONS CAUSED BY HUMAN PAPILLOMA VIRUS". Paper presented in IV International Congress on Health Sciences Research Towards Innovation and Entrepreneurship - Challenges from Research to Clinic, 2023.
  13. Maocha, Izamara; Lopes-Nunes, Jéssica; Rosado, Beatriz; Lopes, Melanie; Rolo, Joana; Palmeira-de-Oliveira, Ana; Palmeira-de-Oliveira, Rita; Martinez-de-Oliveira, José; Cruz, Carla. "SELECTIVE THERAPY AGAINST CERVIVAL LESIONS ASSOCIATED WITH HUMAN PAPILLOMA VIRUS INFECTION". Paper presented in IV International Congress on Health Sciences Research Towards Innovation and Entrepreneurship - Challenges from Research to Clinic, 2023.
  14. Lopes, Melanie; Lopes-Nunes, Jéssica; Maocha, Izamara; Rosado, Beatriz; Rolo, Joana; Palmeira-de-Oliveira, Ana; Palmeira-de-Oliveira, Rita; Martinez-de-Oliveira, José; Cruz, Carla. "NANOPARTICLE DEVELOPMENT TO TREAT HUMAN PAPILLOMA VIRUS RELATED LESION". Paper presented in IV International Congress on Health Sciences Research Towards Innovation and Entrepreneurship - Challenges from Research to Clinic, 2023.
  15. Lopes-Nunes, Jéssica; Oliveira, Paula A; Cruz, Carla. "Development and Evaluation of AT11-guided Liposomes for Human Papillomavirus cancer". Paper presented in 8th International Electronic Conference on Medicinal Chemistry, 2022.
  16. Lopes-Nunes, Jéssica; Paula A Oliveira; Cruz, Carla. "AS1411 derivatives G-quadruplex for Acridine Orange Derivatives Delivery". Paper presented in Innovative ThERApeutiC Targets In nOn-canonical Nucleic acids structures Winter InterNational School 2021, 2021.
  17. Nunes, Jéssica; Oliveira, Paula; Cruz, Carla. "Development of novel aptamer-functionalized liposomes for oral cancer therapy". Paper presented in 7th International Electronic Conference on Medicinal Chemistry, 2021.
  18. Lopes-Nunes, Jéssica; Oliveira, Paula A; Cruz, Carla. "AS1411 derivatives-functionalized liposomes for anticancer drug delivery in oral cancer". Paper presented in 1st Symposium on Advanced Technologies for Drug Delivery, 2021.
  19. Simões, Pedro; Lopes-Nunes, Jéssica; Tomaz, Cândida; Cruz, Carla. "Development of RNA Functionalized Nanoparticle for Oral Cancer Therapy". Paper presented in UT Austin Portugal 2021 Annual Conference, 2021.
  20. Lopes-Nunes, Jéssica; Oliveira, Paula A; Cruz, Carla. "Development of G-Quadruplex Functionalized Liposomes for Anticancer Drugs Delivery". Paper presented in UT Austin Portugal 2021 Annual Conference, 2021.
  21. David Moreira; Lopes-Nunes, Jéssica; Santos, Fátima; Cruz, Carla; Tomaz, Cândida. "DEVELOPMENT OF APTAMER NANOPARTICLES FOR TREATMENT OF RETINAL DISEASES". Paper presented in XVI CICS-UBI Symposium, 2021.
  22. Simões, Pedro; Lopes-Nunes, Jéssica; Tomaz, Cândida; Cruz, Carla. "DEVELOPMENT OF RNA FUNCTIONALIZED NANOPATICLE FOR ORAL CANCER THERAPY". Paper presented in XVI CICS-UBI Symposium, 2021.
  23. Lopes-Nunes, Jéssica; Oliveira, Paula A; Cruz, Carla. "DEVELOPMENT OF G-QUADRUPLEX FUNCTIONALIZED LIPOSOMES FOR ANTICANCER DRUGS DELIVERY". Paper presented in XVI CICS-UBI Symposium, 2021.
  24. Simões, Pedro; Lopes-Nunes, Jéssica; Cruz, Carla. "Desenvolvimento de Nanopartículas Funcionalizadas com RNA para Terapia do Cancro Oral". Paper presented in 3º Encontro Nacional de Jovens Investigadores em Oncologia, 2021.
  25. Lopes-Nunes, Jéssica; Oliveira, Paula A; Cruz, Carla. "Desenvolvimento de lipossomas funcionalizados com aptameros de Gquadruplex para entrega de compostos anticancerígenos". Paper presented in 3º Encontro Nacional de Jovens Investigadores em Oncologia, 2021.
  26. Lopes-Nunes, Jéssica; Oliveira, Paula A.; Cruz, Carla. "TOPICAL FORMULATION OF AS1411 GOLD NANOPARTICLES AS CERVICAL CANCER DRUG DELIVERY SYSTEM". Paper presented in Encontro Ciência '21, 2021.
  27. Lopes-Nunes, Jéssica; Lifante, José; Shen, Yingli; Ximendes, Erving C.; Jaque, Daniel; Iglesias-de la Cruz, M. Carmen; Cruz, Carla. "ICG-tagged aptamer as drug delivery system for malignant melanoma". Paper presented in WG2 ONLINE CA17140 COST CONFERENCE “Characterisation of nanomaterials towards safe and efficient nanodrugs”, 2021.
  28. Lopes-Nunes, Jéssica; Agonia, Ana S; Rosado, Tiago; Gallardo, Eugénia; Palmeira-de-Oliveira, Rita; Palmeira-de-Oliveira, Ana; Martinez-de-Oliveira, José; et al. "Topical Formulation with AS1411-Gold Nanoparticles as Cervical Cancer Drug Delivery System". Paper presented in Applied Nanotechnology and Nanoscience International Conference – ANNIC 2021, 2021.
  29. Lopes-Nunes, Jéssica; Agonia, Ana S; Moutinho, José; Gallardo, Eugénia; Palmeira-de-Oliveira, Rita; Martinez-Oliveira, José; Cruz, Carla. "Formulação de nanopartículas com AS1411 para entrega de fármacos em lesões causadas por HPV". Paper presented in I SEMANA DA INVESTIGAÇÃO DO CHUCB, 2020.
  30. Figueiredo, Joana; Lopes-Nunes, Jéssica; Miranda, André; Carvalho, Josué; Alexandre, Daniela; Valente, Salete; Mergny, Jean-Louis; Cruz, Carla. "Estudo da expressão da nucleolina no cancro do pulmão de não-pequenas células". Paper presented in I SEMANA DA INVESTIGAÇÃO DO CHUCB, 2020.
  31. Lopes-Nunes, Jéssica; Tomás, Mariana; Agonia, Ana S; Rosado, Tiago; Moutinho, José; Gallardo, Eugénia; Palmeira-de-Oliveira, Rita; et al. "AS1411-GOLD NANOPARTICLES AS CERVICAL CANCER DRUG DELIVERY SYSTEM". Paper presented in XV Annual CICS-UBI Symposium, 2020.
  32. Gomes-Maocha, Izamara; Carvalho, Josué; Lopes-Nunes, Jéssica; Tomás, Mariana; Agonia, Ana S; Palmeira-de-Oliveira, Ana; Palmeira-de-Oliveira, Rita; Martinez-de-Oliveira, José; Cruz, Carla. "DEVELOPMENT OF DRUG-LOADED GEL FORMULATIONS FOR INTRAVAGINAL ADMINISTRATION OF ANTI-HPV DRUGS". Paper presented in XV Annual CICS-UBI Symposium, 2020.
  33. Lopes-Nunes, Jéssica; Tomás, Mariana; Ferreira, Sofia; Palmeira-de-Oliveira, Rita; Palmeira-de-Oliveira, Ana; Cruz, Carla. "Desenvolvimento de formulações de nanopartículas para entrega de fármacos para aplicação tópica". Paper presented in 2.º Encontro Nacional Jovens Investigadores em Oncologia, 2020.
  34. Carvalho, Josué; Lopes-Nunes, Jéssica; Milici, Janice; Meyers, Craig; Mergny, Jean-Louis; Salgado, Gilmar F; Cruz, Carla. "TARGETING HUMAN PAPILLOMAVIRUS PROMOTER REGIONS AS A POTENTIAL ANTIVIRAL STRATEGY". Paper presented in IPVC 2020 – The 33rd International Papillomavirus Conference, 2020.
  35. Lopes-Nunes, Jéssica; Palmeira-de-Oliveira, Rita; Palmeira-de-Oliveira, Ana; Martinez-de-Oliveira, José; Cruz, Carla. "Formulation of G-Quadruplex Nanosystem for Cervical Cancer Therapy". Paper presented in III Health Sciences Research Congress: Towards Innovation and Entrepreneurship - Trends in Aging and Cancer, 2019.
  36. Figueiredo, Joana; Lopes-Nunes, Jéssica; Carvalho, Josué; Mergny, Jean-Louis; Cruz, Carla. "Derivados de AS1411 como sistemas de entrega direcionada de ligandos de G-quadruplex para células do cancro cervical". Paper presented in 1º ENCONTRO NACIONAL DE JOVENS INVESTIGADORES EM ONCOLOGIA 2019, 2019.
  37. Lopes-Nunes, Jéssica; Carvalho, Josué; Ferreira L, Catarina; Palmeira-de-Oliveira, Rita; Palmeira-de-Oliveira, Ana; Moutinho, José; Martinez-de-Oliveira, José; Cruz, Carla. "Formulation of a nanosystem-loaded topical gel for cervical cancer therapy". Paper presented in UT Austin Portugal Program 2019 Annual Conference “Create Knowledge, Foster Change: Towards a New Decade of Joint Achievements”, 2019.
  38. Cabral Campello, Maria Paula; Lopes-Nunes, Jéssica; Carvalho, Josué; Gano, Lurdes; Oliveira, Maria Cristina; Peitinho, David; Silva, Francisco; Paulo, António; Cruz, Carla. "Evaluation of the cytotoxic activity of the AS1411-AO-nanosystem for HPV cancer therapy". Paper presented in Nanotechnology in Cancer: Engineering for Oncology, 2019.
  39. Lopes-Nunes, Jéssica; Carvalho, Josué; Cruz, Carla. "G-quadruplex aptamers-gold nanoparticles as drug delivery systems for cervical cancer". Paper presented in Nano Today Conference, 2019.
  40. Afonso, MCV; Sousa, ACA; Bernardino, L; Lopes-Nunes, J; Neves, CMSS; Sharma, M; Freire, MG; Cristóvão, AC. "Testing the application of new antioxidant chemical formulations to prevent neuronal degeneration". Paper presented in XII Annual CICS-UBI Symposium, 2017.
  41. Afonso, MCV; Sousa, ACA; Bernardino, L; Lopes-Nunes, J; Neves, CMSS; Sharma, M; Freire, MG; Cristóvão, AC. "Testing the application of new antioxidant chemical formulations to prevent neuronal degeneration". Paper presented in II International Congress in Health Sciences Research: Towards Innovation and Entrepreneurship – Trends in Biotechnology for Biomedical Applications, 2017.
  42. Lopes-Nunes, J; Afonso, MCV; Santos, T; Esteves, M; Cristóvão, AC; Bernardino, L. "Novel Transcriptional regulation mechanisms associated with Parkinson's disease pathogenesis". Paper presented in II International Congress in Health Sciences Research: Towards Innovation and Entrepreneurship – Trends in Biotechnology for Biomedical Applications, 2017.
Journal article
  1. Figueiredo, Joana; Carreira-Barral, Israel; Lourenço, Pedro; Miranda, André; Lopes Nunes, Jéssica; Quesada, Roberto; Laranjo, Mafalda; Mergny, Jean-Louis; Cruz, Carla. "Synthesis of 1,10-phenanthroline-2,9-bistriazoles: Evaluation as G-quadruplex binders and anti-tumor activity". ChemMedChem (2024): http://dx.doi.org/10.1002/cmdc.202400591.
    10.1002/cmdc.202400591
  2. Lopes-Nunes, Jéssica; Oliveira, Paula A.; Cruz, Carla. "Enhanced targeted liposomal delivery of imiquimod via aptamer functionalization for head and neck cancer therapy". Colloids and Surfaces B: Biointerfaces 243 (2024): 114121. http://dx.doi.org/10.1016/j.colsurfb.2024.114121.
    10.1016/j.colsurfb.2024.114121
  3. Lopes-Nunes, Jéssica; Cabral Campello, Maria Paula; Paulo, António; Nastruzzi, Claudio; Oliveira, Paula A.; Cruz, Carla. "AT11-guided liposomes for oral cancer cells: From characterization towards in vitro evaluation". Journal of Drug Delivery Science and Technology 101 (2024): 106214. http://dx.doi.org/10.1016/j.jddst.2024.106214.
    10.1016/j.jddst.2024.106214
  4. Paulo, António; Oliveira, Maria Cristina; Cabral Campello, Maria Paula; Gano, Lurdes; Raposinho, Paula; Belchior, Ana; Mendes, Edgar; et al. "Evaluation of a Radioiodinated G-quadruplex Binder in Cervical Cancer Models". ChemMedChem (2024): http://dx.doi.org/10.1002/cmdc.202400438.
    10.1002/cmdc.202400438
  5. Lopes-Nunes, Jéssica; Oliveira, Paula A.; Cruz, Carla. "Nanotherapy for human papillomavirus-associated cancers: breakthroughs and challenges". Trends in Pharmacological Sciences 45 9 (2024): 781-797. http://dx.doi.org/10.1016/j.tips.2024.07.004.
    10.1016/j.tips.2024.07.004
  6. Maocha, Izamara; Rosado, Beatriz; Lopes-Nunes, Jéssica; Lopes, Melanie; Rolo, Joana; Pires, Bruno; Gallardo, Eugénia; et al. "Imiquimod-Loaded Nanosystem for Treatment Human Papillomavirus-Induced Lesions". Pharmaceutics 16 7 (2024): 864. http://dx.doi.org/10.3390/pharmaceutics16070864.
    10.3390/pharmaceutics16070864
  7. Lopes-Nunes, Jéssica; Simões, Pedro; Moreira, David; Leandro, Kevin; Nobre, Rui Jorge; de Almeida, Luís Pereira; Campello, Maria Paula Cabral; et al. "RNA-based liposomes for oral cancer: From biophysical characterization to biological evaluation". International Journal of Biological Macromolecules (2024): 129157. http://dx.doi.org/10.1016/j.ijbiomac.2023.129157.
    10.1016/j.ijbiomac.2023.129157
  8. Moreira, David; Lopes-Nunes, Jéssica; Santos, Fátima Milhano; Campello, Maria Paula Cabral; Oliveira, Maria Cristina; Paulo, António; Tomaz, Cândida; Cruz, Carla. "Assessment of Aptamer as a Potential Drug Targeted Delivery for Retinal Angiogenesis Inhibition". Pharmaceuticals 16 5 (2023): 751. http://dx.doi.org/10.3390/ph16050751.
    10.3390/ph16050751
  9. Saraiva, Cláudia; Lopes-Nunes, Jéssica; Esteves, Marta; Santos, Tiago; Vale, Ana; Cristóvão, Ana Clara; Ferreira, Raquel; Bernardino, Liliana. "CtBP Neuroprotective Role in Toxin-Based Parkinson¿s Disease Models: From Expression Pattern to Dopaminergic Survival". Molecular Neurobiology 60 8 (2023): 4246-4260. http://dx.doi.org/10.1007/s12035-023-03331-w.
    10.1007/s12035-023-03331-w
  10. Miranda, André; Lopez-Blanco, Roi; Lopes-Nunes, Jéssica; Melo, Ana M.; Campello, Maria Paula Cabral; Paulo, António; Oliveira, Maria Cristina; et al. "Gallic Acid–Triethylene Glycol Aptadendrimers Synthesis, Biophysical Characterization and Cellular Evaluation". Pharmaceutics 14 11 (2022): 2456. http://dx.doi.org/10.3390/pharmaceutics14112456.
    10.3390/pharmaceutics14112456
  11. Moreira, David; Leitão, Daniela; Lopes-Nunes, Jéssica; Santos, Tiago; Figueiredo, Joana; Miranda, André; Alexandre, Daniela; et al. "G-Quadruplex Aptamer-Ligand Characterization". Molecules 27 20 (2022): 6781. http://dx.doi.org/10.3390/molecules27206781.
    10.3390/molecules27206781
  12. Santos, Tiago; Lopes-Nunes, Jéssica; Alexandre, Daniela; Miranda, André; Figueiredo, Joana; Silva, Micael S.; Mergny, Jean-Louis; Cruz, Carla. "Stabilization of a DNA aptamer by ligand binding". Biochimie 200 (2022): 8-18. http://dx.doi.org/10.1016/j.biochi.2022.05.002.
    10.1016/j.biochi.2022.05.002
  13. Maocha, Izamara Gomes; Carvalho, Josué; Lopes-Nunes, Jéssica; Rosado, Tiago; Gallardo, Eugénia; Tomás, Mariana; Palmeira-de-Oliveira, Ana; et al. "Drug formulations for localized treatment of Human Papillomavirus-induced lesions". Journal of Pharmaceutical Sciences (2022): http://dx.doi.org/10.1016/j.xphs.2022.02.004.
    10.1016/j.xphs.2022.02.004
  14. Carvalho, Josué; Lopes-Nunes, Jéssica; Figueiredo, Joana; Santos, Tiago; Miranda, André; Riscado, Micaela; Sousa, Fani; et al. "Molecular Beacon Assay Development for Severe Acute Respiratory Syndrome Coronavirus 2 Detection". Sensors 21 21 (2021): 7015. http://dx.doi.org/10.3390/s21217015.
    10.3390/s21217015
  15. Figueiredo, Joana; Santos, Tiago; Miranda, André; Alexandre, Daniela; Teixeira, Bernardo; Simões, Pedro; Lopes-Nunes, Jéssica; Cruz, Carla. "Ligands as Stabilizers of G-Quadruplexes in Non-Coding RNAs". Molecules 26 20 (2021): 6164. http://dx.doi.org/10.3390/molecules26206164.
    10.3390/molecules26206164
  16. Lopes-Nunes, Jessica; Agonia, Ana S.; Rosado, Tiago; Gallardo, Eugénia; Palmeira-de-Oliveira, Rita; Palmeira-de-Oliveira, Ana; Martinez-de-Oliveira, José; et al. "Aptamer-Functionalized Gold Nanoparticles for Drug Delivery to Gynecological Carcinoma Cells". Cancers 13 16 (2021): 4038. http://dx.doi.org/10.3390/cancers13164038.
    Published • 10.3390/cancers13164038
  17. Lopes-Nunes, Jéssica; Oliveira, Paula A; Cruz, Carla. "G-Quadruplex-Based Drug Delivery Systems for Cancer Therapy". Pharmaceuticals 14 7 (2021): 671. https://doi.org/10.3390/ph14070671.
    Published • https://doi.org/10.3390/ph14070671
  18. Carvalho, Josué; Lopes-Nunes, Jéssica; Vialet, Brune; Rosado, Tiago; Gallardo, Eugenia; Vale, João; Eloy, Catarina; et al. "Nanoaggregate-forming lipid-conjugated AS1411 aptamer AS a promising tumor-targeted delivery system of anticancer agents in vitro". Nanomedicine: Nanotechnology, Biology and Medicine (2021): 102429. http://dx.doi.org/10.1016/j.nano.2021.102429.
    10.1016/j.nano.2021.102429
  19. Figueiredo, Joana; Miranda, André; Lopes-Nunes, Jéssica; Carvalho, Josué; Alexandre, Daniela; Valente, Salete; Mergny, Jean-Louis; Cruz, Carla. "Targeting nucleolin by RNA G-quadruplex-forming motif". Biochemical Pharmacology (2021): 114418. http://dx.doi.org/10.1016/j.bcp.2021.114418.
    10.1016/j.bcp.2021.114418
  20. Lopes-Nunes, Jéssica; Lifante, José; Shen, Yingli; Ximendes, Erving C.; Jaque, Daniel; Iglesias-de la Cruz, M. Carmen; Cruz, Carla. "Biological studies of an ICG-tagged aptamer as drug delivery system for malignant melanoma". European Journal of Pharmaceutics and Biopharmaceutics 154 (2020): 228-235. http://dx.doi.org/10.1016/j.ejpb.2020.07.018.
    10.1016/j.ejpb.2020.07.018
  21. Lopes-Nunes, Jéssica; Carvalho, Josué; Figueiredo, Joana; Ramos, Catarina I.V.; Lourenço, Leandro M.O.; Tomé, João P.C.; Neves, Maria G.P.M.S.; et al. "Phthalocyanines for G-quadruplex aptamers binding". Bioorganic Chemistry 100 (2020): 103920. http://dx.doi.org/10.1016/j.bioorg.2020.103920.
    Published • 10.1016/j.bioorg.2020.103920
  22. Carvalho, Josué; Lopes-Nunes, Jéssica; Cabral Campello, Maria Paula; Paulo, António; Milici, Janice; Meyers, Craig; Mergny, Jean-Louis; et al. "Human Papillomavirus G-Rich Regions as Potential Antiviral Drug Targets". Nucleic Acid Therapeutics (2020): https://doi.org/10.1089/nat.2020.0869.
    Published
  23. Figueiredo, Joana; Lopes-Nunes, Jéssica; Carvalho, Josué; Antunes, Francisca; Ribeiro, Márcia; Campello, Maria Paula Cabral; Paulo, António; et al. "AS1411 derivatives as carriers of G-quadruplex ligands for cervical cancer cells". International Journal of Pharmaceutics (2019): 118511. http://dx.doi.org/10.1016/j.ijpharm.2019.118511.
    Published • 10.1016/j.ijpharm.2019.118511
  24. Carvalho, Josué; Lopes-Nunes, Jéssica; Lopes, Ana Catarina; Cabral Campello, Maria Paula; Paulo, António; Queiroz, João A.; Cruz, Carla. "Aptamer-guided acridine derivatives for cervical cancer". Organic & Biomolecular Chemistry 17 11 (2019): 2992-3002. http://dx.doi.org/10.1039/c9ob00318e.
    Published • 10.1039/c9ob00318e
Thesis / Dissertation
  1. Nunes, Jéssica. "Novel transcriptional regulation mechanisms associated with Parkinson’s disease pathogenesis: from biological activity towards therapy". Master, Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, 2017.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/10/16 Nucleic acid functionalized nanoparticles for Human Papillomavirus related lesions LUNCH SEMINAR CICS-UBI
CICS-UBI (Covilhã, Portugal)
2024/07/16 AT11-Guided Liposomes: Potential Therapeutic Approach for Oral Cancer Cells XIX Annual CICS-UBI Symposium
CICS-UBI (Covilhã, Portugal)
2024/02/05 Aptamer-guided nanocarriers for Human Papilloma Virus related lesions Cancer Research by PhD students at CICS-UBI
CICS-UBI (Covilhã, Portugal)
2023/07/11 LIPOSOMES FUNCTIONALIZED WITH THE APTAMER G- QUADRUPLEX FOR SELECTIVE DRUG DELIVERY FOR LUNG CANCER TREATMENT XVIII International CICS-UBI Symposium
2023/07/04 Aptamer-guided nanocarriers for Human Papilloma Virus related lesions My 3-min PhD Thesis
(Covilhã)
2023/02/23 Production of aptamer-guided liposomes for head and neck cancer treatment 2nd CA17140 STSM Virtual Conference
CA17140 Cost Action
2022/10/26 ICG-tagged aptamer as drug delivery system for in vitro and in vivo malignant melanoma models Final CA17140 Conference
Cost Action CA17140 (Rome, Italy)
2022/09/24 NANOPARTÍCULAS DE OURO FUNCIONALIZADAS COM APTAMERO DE DNA PARA ENTREGA DE FÁRMACOS A CÉLULAS DE CARCINOMAS GINECOLÓGICOS 4º Encontro Nacional de Jovens Investigadores em Oncologia
Liga Portuguesa Contra o Cancro (Porto, Portugal)
2022/03/16 ICG-tagged aptamer as drug delivery system for malignant melanoma 1st CA17140 STSM VIRTUAL CONFERENCE
Cost Action CA17140
2019/11/14 Human Papillomavirus G-rich Regions as Potential Targets for Antiviral Drug Development III International Congress in Health Sciences Research: Towards Innovation and Entrepreneurship - Trends in Aging
CICS-UBI Doctoral Students Committee (Covilhã, Portugal)
2019/10/15 G-quadruplexes Nanosystems for Cancer Therapy 1st CA17140 Conference
Cost Action CA17140 (Riga, Latvia)
2019/07/05 Aptamer-guided acridine derivatives for cervical cancer XIV Annual CICS-UBI Symposium
Universidade da Beira Centro de Investigação em Ciências da Saúde (Covilhã, Portugal)
2019/07/05 AS1411 derivatives as carriers of G-quadruplex ligands for cervical cancer cells XIV Annual CICS-UBI Symposium
Universidade da Beira Centro de Investigação em Ciências da Saúde (Covilhã, Portugal)
2019/06/20 AS1411 aptamer-conjugated polymeric micelle for the delivery of antiviral and anticancer agents 6th Nano Today Conference
Nano Today journal; NanoBio Lab; Elsevier (Lisbon, Portugal)
2018/07 Neuroprotective Role of CtBPs on In Vitro and In Vivo Models for Parkinson’s Disease XIII Annual CICS-UBI Symposium
(Covilhã, Portugal)
2017/07 Expression pattern and the protective effect of CtBPs on experimental models for Parkinson's disease XII Annual CICS-UBI Symposium
(Covilhã, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2022 - 2023 Development of a vaginal gel to treat intra-epithelial lesions caused by HPV
Co-supervisor
 Bioquímica (Master)
Universidade da Beira Interior, Portugal
2022 - 2023 Lipidic aptamer-nanoparticle development for HPV associated cervical cancer
Co-supervisor
 Bioquímica (Master)
Universidade da Beira Interior, Portugal
2021/07 - 2022/10 Development of RNA-based nanoparticles for cancer therapy
Co-supervisor
 Biomedical Sciences (Master)
Universidade da Beira Interior, Portugal
2019/02/19 - 2019/06/07 Nanopartículas de ouro guiadas por aptameros de G-quadruplex para entrega de fármacos em células tumorais do colo do útero
Co-supervisor
 Biochemistry (Degree)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2016/07 - 2017/10/14 Member of the organization Committee of the 10th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (2017/10/12 - 2017/10/14)
Congress (Member of the Organising Committee)
 Universidade da Beira Interior, Portugal
2016/02 - 2016/05/11 Organization Committee of the V Symposium – Employment and Opportunities in Biomedical Sciences, within the curricular unit of Project in Biomedical Sciences (2016/05/11 - 2016/05/11)
Symposium (Member of the Organising Committee)
 Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2024/02/04 - Current Communication entitled "Aptamer-guided nanocarriers for Human Papilloma Virus related lesions" at Cancer Research by PhD Students at CICS-UBI – World Cancer Day;
Other
 Cancer Research by PhD Students at CICS-UBI – World Cancer Day;
Universidade da Beira Interior, Portugal
2019/11/14 - 2019/11/16 Attendance at III International Congress in Health Sciences Research: Towards Innovation and Entrepreneurship - Trends in Aging and Cancer
Congress
 III International Congress in Health Sciences Research: Towards Innovation and Entrepreneurship - Trends in Aging and Cancer
2019/09/20 - 2019/09/20 Attendance at UT Austin Portugal Program 2019 Annual Conference “Create Knowledge, Foster Change: Towards a New Decade of Joint Achievements”
Conference
 UT Austin Portugal Program 2019 Annual Conference “Create Knowledge, Foster Change: Towards a New Decade of Joint Achievements”
2019/07/04 - 2019/07/05 Attendance at XIV Annual CICS-UBI Symposium
Symposium
 XIV Annual CICS-UBI Symposium
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2019/06/16 - 2019/06/20 Attendance at 6th Nano Today Conference
Conference
 6th Nano Today Conference
NanoBio Lab, Singapore

Elsevier BV, Netherlands
2018/07/05 - 2018/07/06 Attendance at XIII Annual CICS-UBI Symposium
Symposium
 XIII Annual CICS-UBI Symposium
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2017/07/06 - 2017/07/07 Attendance at XII Annual CICS-UBI Symposium
Symposium
 XII Annual CICS-UBI Symposium
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2017/05/17 - 2017/05/20 Attendance at II Congress in Health Sciences Research Towards Innovation and Entrepreneurship – Trends in Biotechnology for Biomedical Applications
Congress
 II Congress in Health Sciences Research Towards Innovation and Entrepreneurship – Trends in Biotechnology for Biomedical Applications
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2017/02/01 - 2017/02/01 Attendance at Mini-Symposium – Advanced Models in Neuroscience Research
Symposium
 Mini-Symposium – Advanced Models in Neuroscience Research
Universidade de Lisboa Faculdade de Farmácia, Portugal
2016/06/30 - 2016/07/01 Attendance at XI Annual CICS-UBI Symposium
Symposium
 XI Annual CICS-UBI Symposium
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2015/11/26 - 2015/11/28 Attendance at I Congress in Health Sciences Research Towards Innovation and Entrepreneurship – Trends in Endocrinology and Neurosciences
Congress
 I Congress in Health Sciences Research Towards Innovation and Entrepreneurship – Trends in Endocrinology and Neurosciences
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024/06/11 In cell evaluation of G-quadruplex in cell lines of lung cancer
(Thesis) Main arguer
 Diogo André da Silva Dias (Other)
Universidade da Beira Interior, Portugal
2019/06/26 Estudo do efeito do solvente na formulação de micelas funcionalizadas com aptâmeros
(Thesis) Main arguer
 Ricardo Guerra (Other)
Universidade da Beira Interior, Portugal

Mentoring / Tutoring

Topic Student name
2022/07 - 2022/07 International Federation of Medical Students’ Associations (IFMSA) Exchange Program Marvel Onassis
Distinctions

Award

2023 3.º lugar da Categoria Inovação na 11ª Edição do Concurso de Ideias de Negócio ARRISCA C, Programa INOVC+
2023 Honorable mention (Poster) at the XV Jornadas de Genética y Biotecnología / V Jornadas Ibéricas de Genética y Biotecnología
Universidad de León, Spain

Universidade de Trás-os-Montes e Alto Douro, Portugal
2023 1.º lugar WIN-UBI - Concurso de Ideias de Negócio
2023 2.º lugar Pitch dos projetos vencedores das 7 Universidades UI-CAN
2023 1º Lugar Making Health Safer
Associação FabLabs Portugal, Portugal
2019 Awarded with a Short Term Scientific Mission in the scope of COST Action CA17140 (CA17140-45161), Universidad Autónoma de Madrid, Spain
COST Action CA17140, Spain
2017 "Best Poster Award" in II International Congress in Health Sciences Research towards innovation and entrepreneurship: Trends in Biotechnology for Biomedical Applications