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Senior Specialist in Internal Medicine, Specialist in Medical Oncolgy, coordinator of the Autoimmune Diseases Clinic, at the Hospital de Santo Espirito da Ilha Terceira (HSEIT EPER), Azores, Portugal. He was the Director of the Genetics & Arthritis Research Group (GARG) at the Institute for Molecular and Cell Biology (IBMC), University of Porto, Portugal until December 2016. He was Investigator at the iNOVA4Health - Programa de Medicina Translacional (iBET, CEDOC/FCM, IPOFLG, ITQB). He was an Investigator at the Comprehensive Health Research Centre (CHRC). He was also Director of the Epidemiology and Molecular Biology Service (SEEBMO) at the HSEIT EPER. Research interests are mainly the epidemiology and molecular genetics of Spondylarthritis (SpA), Diffuse Idiopathic Skeletal Hyperostosis (DISH), and Chondrocalcinosis (CC).
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Identification

Personal identification

Full name
Jacome Ornelas Bruges Armas

Citation names

  • Bruges Armas, J.
  • Armas, JB
  • Armas, J.

Author identifiers

Ciência ID
8413-FBC3-5584
ORCID iD
0000-0001-7671-6521

Telephones

Mobile phone
  • 967359388 (Personal)

Addresses

  • Caminho do Meio de São Carlos, 90, 9700-222, São Pedro, Angra do Heroísmo, Portugal (Personal)

Knowledge fields

  • Medical and Health Sciences
  • Medical and Health Sciences - Clinical Medicine - Rheumatology
  • Medical and Health Sciences - Clinical Medicine - Oncology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Upper intermediate (B2) Advanced (C1)
Spanish; Castilian Upper intermediate (B2) Advanced (C1) Intermediate (B1) Advanced (C1) Advanced (C1)
French Elementary (A2) Upper intermediate (B2) Intermediate (B1) Intermediate (B1) Advanced (C1)
Catalan Beginner (A1) Elementary (A2) Beginner (A1) Elementary (A2) Elementary (A2)
Education
Degree Classification
2007 - 2023
Concluded
 Assistente Graduado Sénior/Chefe de serviço de medicina interna (Outros)
Hospital de Santo Espírito da Ilha Terceira EPER, Portugal
1996 - 2001
Concluded
 Ciências Médicas (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
1995
Concluded
 Medical Oncology (Especialização pós-licenciatura)
Portuguese Medical Council, Portugal
1989
Concluded
 Internal Medicine (Especialização pós-licenciatura)
Portuguese Medical Residency, Portugal
1973 - 1979
Concluded
 Medicina (Licenciatura)
Universidade de Coimbra, Portugal
 17
Affiliation

Science

Category
Host institution 		Employer
2017 - 2023 Principal Investigator (Research) Universidade NOVA de Lisboa Comprehensive Health Research Centre, Portugal
Universidade Nova de Lisboa Medical School, Portugal
2017/01/02 - 2017/12/31 Researcher (Research) iNOVA4Health, Portugal

Positions / Appointments

Category
Host institution 		Employer
2020 - 2023/10/30 Director of Medical Oncology Hospital de Santo Espírito da Ilha Terceira EPER, Portugal
1999 - 2023/10/30 Diretor of SEEBMO (Serviço Especializado de Epidemiologia e Biologia Molecular) Hospital de Santo Espírito da Ilha Terceira EPER, Portugal
2005/01/01 - 2017/01/01 Organic Unit Director Instituto de Biologia Molecular e Celular, Portugal
Projects

Grant

Designation Funders
2007 - 2013 MTBIOBANCO
MAC/1/AO14
 INTERREG III MAC MAC 2007-2013
2008 - 2012 RIRCE
PT0023 (2008/2012)
 EEA Grants
2010 - 2011 MANSEEBMO
M1.2.1/I/006/2010
 Direção regional da Ciência e Tecnologia
2009 - 2010 REQUIPSEEBMO
M2.1.3/I/2009
 Direção regional da Ciência e Tecnologia
2008 - 2010 MANSEEBMO
M1.2.1/I/005/2008
 Direção regional da Ciência e Tecnologia
2005 - 2008 MANSEEBMO
M1.2.1/I/004/2005
 Direção regional da Ciência e Tecnologia

Contract

Designation Funders
2016/05/01 - 2020/03/31 Iniciativa Europeia para a ataxia espinocerebelosa do tipo 3/doença de Machado-Joseph
JPCOFUND/0002/2015
Fundação Gaspar Frutuoso, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2016/06/01 - 2019/03/29 Sequenciação do exoma de pares discordantes e concordantes de irmãos com ataxia espino-cerebelosa do tipo 3 SCA3: uma ferramenta para identificar novos modificadores e investigar vias moleculares alteradas.
PTDC/DTP-PIC/2638/2014
Instituto de Biologia Molecular e Celular, Portugal

Fundação Gaspar Frutuoso, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2013/05/01 - 2015/09/30 Identifying Molecular Endpoints for Machado-Joseph disease MJD/SCA3: evaluation of transcriptional candidate biomarkers in peripheral blood.
PTDC/DTP-PIC/0370/2012
Instituto de Biologia Molecular e Celular, Portugal

Universidade dos Açores, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/04/01 - 2013/12/31 Compreender o potencial das bactérias do ácido láctico BAL: Benefícios nutricionais e melhoria da segurança em queijos
PTDC/AGR-ALI/104385/2008
Universidade dos Açores Instituto de Investigação e Tecnologia da Agronomia e Meio Ambiente, Portugal

Fundação Gaspar Frutuoso, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2009/01/01 - 2011/05/30 Variação na transcrição do gene da ATXN3 como factor modelador da variabilidade clínica na doença de Machado-Joseph DMJ.
PIC/IC/83074/2007
Universidade dos Açores Centro de Investigação em Recursos Naturais, Portugal

Universidade dos Açores, Portugal

Hospital de Santo Espírito da Ilha Terceira EPER, Portugal

Hospital do Divino Espírito Santo de Ponta Delgada EPE, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2005/01/01 - 2007/05/31 Diversidade Genética do Sistema HLA em Populações Africanas
POCI/BIA-BCM/60440/2004
Hospital de Santo Espírito da Ilha Terceira EPER, Portugal

Universidade da Madeira, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
1995 - 1997 ANTIGÉNES
NA
Supervisor
Hospital de Santo Espírito da Ilha Terceira EPER, Portugal
Concluded
Outputs

Publications

Book
  1. Bruges Armas, J.. Ankylosing Spondylitis - Recent Concepts. London, United Kingdom: IntechOpen. 2023.
    Published • Editor
  2. Jacome Bruges-Armas. Clinical and Molecular Advances in Ankylosing Spondylitis. {InTech. 2012.
    10.5772/1057
  3. Armas, Jacome. Seminário do Projecto RIRCE. Contribuição para o conhecimento da epidemiologia da epilepsia pediátrica. Portugal. 2011.
Book chapter
  1. Bruges Armas, Jácome. "Introductory Chapter: AS Times Go by – An Axial Chronicle". In Ankylosing Spondylitis - Recent Concepts. IntechOpen, 2023.
    10.5772/intechopen.111723
  2. Foroni, Iris; Rita, Ana; Filipe, Bruno; Santos, Margarida; Lima, Manuela; Bruges-Armas, Jcome. "HLA-E, HLA-F and HLA-G The Non-Classical Side of the MHC Cluster". In HLA and Associated Important Diseases. InTech, 2014.
    10.5772/57507
  3. Armas, Jacome. "Human Papillomavirus Worldwide Distribution in Women Without Cervical Cancer". In Research Aspects, 37-64. Croatia: INTECH, 2012.
    Published
  4. Armas, Jacome. "Genetics in Ankylosing Spondylitis - Beyond HLA-B*27". In Clinical and Molecular Advances in Ankylosing Spondylitis, 103-134. In Tech, 2012.
    Published
  5. Lima, Manuela; Bruges-Armas, Jcome; Bettencourt, Conceio. "Non-Mendelian Genetic Aspects in Spinocerebellar Ataxias (SCAS): The Case of Machado-Joseph Disease (MJD)". In Spinocerebellar Ataxia. InTech, 2012.
    Published • 10.5772/30319
  6. Dutra, I.; Foroni, I.; Couto, A.R.; Lima, M.; Bruges-Armas, J.. "Molecular Diagnosis of Human Papillomavirus". In Human Papillomavirus and Related Diseases - From Bench to Bedside - Research aspects. InTech, 2012.
    10.5772/30165
  7. Armas, Jacome. "Spondyloarthritis, Diffuse Idiopathic Skeletal Hyperostosis (DISH) and Chondrocalcinosis". In Molecular Mechanisms of Spondyloarthropathies-Advances in Experimental Medicine and Biology,, 37-56. New York, United States: Landes Bioscience and Springer Science+Business Media, 2009.
  8. Armas, Jacome. "Update on the Immunogenetics of Spondyloarthritis". 241-253. New York, United States: Nova Science Publishers, 2005.
    Published
Conference paper
  1. Guiomar, Raquel; Pechirra, Pedro; Cristóvão, Paula; Costa, Inês; Conde, Patrícia; Côrte-Real, Rita; Branquinho, Paula; et al. "Influenza virus type/subtype and different infection profiles by age group during 2017/2018 season". 2018.
  2. Guiomar, Raquel; Pechirra, Pedro; Costa, Inês; Cristóvão, Paula; Conde, Patrícia; Nunes, Baltazar; Rodrigues, Ana Paula; et al. "Severe RSV infections in children and elderly during 2017/2018 winter season". 2018.
  3. Guiomar, Raquel; Pechirra, Pedro; Cristóvão, Paula; Costa, Inês; Conde, Patrícia; Corte-Real, Rita; Branquinho, Paula; et al. "Influenza severe cases in hospitals, between 2014 and 2016 in Portugal". 2016.
  4. Guiomar, Raquel; Cristóvão, Paula; Conde, Patrícia; Costa, Inês; Pechirra, Pedro; Rodrigues, Ana Paula; Pereira da Silva, Susana; et al. "Influenza seroprotection correlates with predominant circulating viruses during 2014/15 and 2015/16 seasons in Portugal". 2016.
  5. Guiomar, Raquel; Pechirra, Pedro; Conde, Patrícia; Cristóvão, Paula; Maia, Ana Carina; Silvestre, Maria José; Almeida Santos, Madalena; et al. "Rede Portuguesa de Laboratórios para o Diagnóstico da Gripe: inverno 2013/2014". 2014.
  6. Guiomar, Raquel; Pechirra, Pedro; Conde, Patrícia; Cristóvão, Paula; Silvestre, Maria José; Almeida Santos, Madalena; Sobrinho Simões, Joana; et al. "Severe acute respiratory infections in the 2012/2013 season studied by the Portuguese Laboratory Network for Influenza Diagnosis". 2013.
  7. Pechirra, Pedro; Gonçalves, Paulo; Conde, Patrícia; Guiomar, Raquel; Duque, Vítor; Vaz, João; Ribeiro, Graça; et al. "Characterisation of respiratory disease during the 2010/2011 influenza winter season in Portugal: Contribute of the Laboratory Network for the Diagnosis of Influenza A(H1N1)2009 Infection". 2011.
Journal article
  1. Guiomar, Raquel; Pereira da Silva, Susana; Costa, Inês; Conde, Patricia; Cristóvão, Paula; Rodrigues, Ana Paula; Fernandes, Aida; et al. "Seroprevalence of Protective Antibodies Against Influenza and the Reduction of the Influenza Incidence Rate: An Annual Repeated Cross-Sectional Study From 2014 to 2019". Influenza and Other Respiratory Viruses 18 5 (2024): http://dx.doi.org/10.1111/irv.13307.
    10.1111/irv.13307
  2. Bruna Parreira; Ana Rita Couto; Luís Pinheiro; Jácome Bruges-Armas. "Genetic basis for skeletal new bone formation". Exploration of Musculoskeletal Diseases (2023): https://doi.org/10.37349/emd.2023.00018.
    10.37349/emd.2023.00018
  3. Torres, Ana Rita; Guiomar, Raquel Guiomar; Verdasca, Nuno; Melo, Aryse; Rodrigues, Ana Paula; On behalf of Laboratórios para o Diagnóstico da Gripe. "Resurgence of Respiratory Syncytial Virus in Children: An Out-of-Season Epidemic in Portugal". Acta Médica Portuguesa (2023): http://dx.doi.org/10.20344/amp.18589.
    10.20344/amp.18589
  4. Borges, Vítor; Isidro, Joana; Trovão, Nídia Sequeira; Duarte, Sílvia; Cortes-Martins, Helena; Martiniano, Hugo; Gordo, Isabel; et al. "SARS-CoV-2 introductions and early dynamics of the epidemic in Portugal". Communications Medicine 2 1 (2022): http://dx.doi.org/10.1038/s43856-022-00072-0.
    10.1038/s43856-022-00072-0
  5. Madalena Sousa; Teresa Rego; Jácome Bruges Armas. "Insights into the Genetics and Signaling Pathways in Maturity-Onset Diabetes of the Young". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms232112910.
    10.3390/ijms232112910
  6. Couto AR; Parreira B; Power DM; Pinheiro L; Madruga Dias J; Novofastovski I; Eshed I; et al. "Evidence for a genetic contribution to the ossification of spinal ligaments in Ossification of Posterior Longitudinal Ligament and Diffuse idiopathic skeletal hyperostosis: A narrative review.". Frontiers in genetics (2022): https://europepmc.org/articles/PMC9586552.
    10.3389/fgene.2022.987867
  7. Saba Abdulghani; Ângela Afonso; Mireia Castillo; Javier Martín-Fernández; Inês Franco; Bruna Parreira; Ana Couto; et al. "The Role of Biobanks in the Fight against COVID-19 Pandemic: The Portuguese Response". Acta Médica Portuguesa (2022): https://doi.org/10.20344/amp.17856.
    10.20344/amp.17856
  8. Raposo, Mafalda; Bettencourt, Conceição; Melo, Ana Rosa Vieira; Ferreira, Ana F.; Alonso, Isabel; Silva, Paulo; Vasconcelos, João; et al. "Novel Machado-Joseph disease-modifying genes and pathways identified by whole-exome sequencing". Neurobiology of Disease 162 (2022): 105578. http://dx.doi.org/10.1016/j.nbd.2021.105578.
    10.1016/j.nbd.2021.105578
  9. Silveira, Catarina; Sousa, Ana Carla; Janeiro, André; Malveiro, Sara; Teixeira, Encarnação; Brysch, Eva; Pantarotto, Marcos; et al. "Detection and quantification of EGFR T790M mutation in liquid biopsies by droplet digital PCR". Translational Lung Cancer Research 10 3 (2021): 1200-1208. http://dx.doi.org/10.21037/tlcr-20-1010.
    10.21037/tlcr-20-1010
  10. Mader, Reuven; Pappone, Nicola; Baraliakos, Xenofon; Eshed, Iris; Sarzi-Puttini, Piercarlo; Atzeni, Fabiola; Bieber, Amir; et al. "Diffuse Idiopathic Skeletal Hyperostosis (DISH) and a Possible Inflammatory Component". Current Rheumatology Reports 23 1 (2021): http://dx.doi.org/10.1007/s11926-020-00972-x.
    10.1007/s11926-020-00972-x
  11. Sousa, Madalena; Bruges-Armas, Jácome. "Monogenic Diabetes: Genetics and Relevance on Diabetes Mellitus Personalized Medicine". Current Diabetes Reviews 16 8 (2020): 807-819. http://dx.doi.org/10.2174/1573399816666191230114352.
    10.2174/1573399816666191230114352
  12. Borges, Vítor; Isidro, Joana; Cortes-Martins, Helena; Duarte, Sílvia; Vieira, Luís; Leite, Ricardo; Gordo, Isabel; et al. "Massive dissemination of a SARS-CoV-2 Spike Y839 variant in Portugal". Emerging Microbes & Infections 9 1 (2020): 2488-2496. http://dx.doi.org/10.1080/22221751.2020.1844552.
    10.1080/22221751.2020.1844552
  13. Armas, Jacome. "Whole exome sequencing of patients with diffuse idiopathic skeletal hyperostosis and calcium pyrophosphate crystal chondrocalcinosis". Acta Reumatol Port. 45 2 (2020): 116-126.
    Published
  14. Sáez-López, Emma; Cristóvão, Paula; Costa, Inês; Pechirra, Pedro; Conde, Patrícia; Guiomar, Raquel; Peres, Maria João; et al. "Epidemiology and genetic variability of respiratory syncytial virus in Portugal, 2014-2018". (2019): http://hdl.handle.net/10400.18/6599.
    10.1016/j.jcv.2019.104200
  15. Armas, Jacome. "Persistence of the ABCC6 genes and the emergence of the bony skeleton in vertebrates". Scientific Reports (2018): http://10.1038/s41598-018-24370-7.
  16. Santos, Margarida Rodrigues; Couto, Ana Rita; Foroni, Iris; Bettencourt, Bruno Filipe; Li, Zhixiu; Meneses, Raquel; Wheeler, Lawrie; et al. "Non-classical human leucocyte antigens in ankylosing spondylitis: possible association with HLA-E and HLA-F". RMD Open . 4 1 (2018): http://www.scopus.com/inward/record.url?scp=85049483719&partnerID=8YFLogxK.
    Published • https://doi.org/10.1136/rmdopen-2018-000677
  17. Armas, Jacome. "Human leucocyte antigens class II allele and haplotype association with Type 1 Diabetes in Madeira Island (Portugal).". International journal of immunogenetics (2017): http://europepmc.org/abstract/med/28834219.
    10.1111/iji.12335
  18. Armas, Jacome; Guiomar, Raquel; Pereira da Silva, Susana; Conde, Patrícia; Cristóvão, Paula; Maia, Ana Carina; Pechirra, Pedro; et al. "Cross-protection to new drifted influenza A(H3) viruses and prevalence of protective antibodies to seasonal influenza, during 2014 in Portugal.". Vaccine (2017): http://europepmc.org/abstract/med/28318771.
    10.1016/j.vaccine.2017.02.019
  19. Armas, Jacome. "Promoter Variation and Expression Levels of Inflammatory Genes IL1A, IL1B, IL6 and TNF in Blood of Spinocerebellar Ataxia Type 3 (SCA3) Patients.". Neuromolecular medicine (2017): http://europepmc.org/abstract/med/27246313.
    10.1007/s12017-016-8416-8
  20. Armas, Jacome. "HLA-DQA1 and HLA-DQB1 allele diversity and its extended haplotypes in Madeira Island (Portugal).". International journal of immunogenetics (2017): http://europepmc.org/abstract/med/28032448.
    10.1111/iji.12300
  21. Armas, Jacome. "Combined approach for finding susceptibility genes in DISH/chondrocalcinosis families: whole-genome-wide linkage and IBS/IBD studies.". Human genome variation (2017): http://europepmc.org/abstract/med/29104755.
    10.1038/hgv.2017.41
  22. Armas, Jacome. "Diffuse idiopathic skeletal hyperostosis (DISH): where we are now and where to go next.". RMD open (2017): http://europepmc.org/abstract/med/28955488.
    10.1136/rmdopen-2017-000472
  23. Armas, Jacome. "Killer-cell immunoglobulin-like receptors genotyping of 127 individuals from Terceira Island, Azores, Portugal.". Human immunology (2016): http://europepmc.org/abstract/med/27503788.
    10.1016/j.humimm.2016.08.002
  24. Armas, Jacome. "Triplet Repeat Primed PCR (TP-PCR) in Molecular Diagnostic Testing for Spinocerebellar Ataxia Type 3 (SCA3).". Molecular diagnosis & therapy (2016): http://europepmc.org/abstract/med/27647319.
    10.1007/s40291-016-0235-y
  25. Armas, Jacome. "HLA-A, -B, -C, -DQA1, -DQB1, -DRB1, -E, -F and -G genotyping of 130 individuals from Terceira Island, Azores, Portugal.". Human immunology (2016): http://europepmc.org/abstract/med/27041245.
    10.1016/j.humimm.2016.03.008
  26. "Verification of Inter-laboratorial Genotyping Consistency in the Molecular Diagnosis of Polyglutamine Spinocerebellar Ataxias.". Journal of molecular neuroscience : MN (2016): http://europepmc.org/abstract/med/26454745.
    10.1007/s12031-015-0646-y
  27. Armas, Jacome. "A Single Nucleotide Polymorphism in the Il17ra Promoter Is Associated with Functional Severity of Ankylosing Spondylitis.". PLoS ONE (2016): http://europepmc.org/abstract/med/27415816.
    10.1371/journal.pone.0158905
  28. Armas, Jacome; Canhão, Helena; Rodrigues, Ana Maria; Santos, Maria José; Carmona-Fernandes, Diana; Bettencourt, Bruno F.; Cui, Jing; et al. "TRAF1/C5 but not PTPRC variants are potential predictors of rheumatoid arthritis response to anti-tumor necrosis factor therapy.". BioMed Research International (2015): http://europepmc.org/abstract/med/25834819.
    10.1155/2015/490295
  29. Raposo, Mafalda; Bettencourt, Conceição; Maciel, P.; Gao, Fuying; Ramos, Amanda; Kazachkova, Nadiya; Vasconcelos, João; et al. "Novel candidate blood-based transcriptional biomarkers of Machado-Joseph disease". Movement disorders : official journal of the Movement Disorder Society (2015): http://hdl.handle.net/1822/42783.
    10.1002/mds.26238
  30. Mourão, Ana Filipa; Santos, Maria José; Mendonça, Sílvia; Oliveira-Ramos, Filipa; Salgado, Manuel; Estanqueiro, Paula; Melo-Gomes, José; et al. "Genetic Predictors of Poor Prognosis in Portuguese Patients with Juvenile Idiopathic Arthritis". (2015): http://www.scopus.com/inward/record.url?scp=84945389456&partnerID=8YFLogxK.
    https://doi.org/10.1155/2015/706515
  31. Armas, Jacome. "Familial hypercholesterolemia: Molecular characterization of possible cases from the Azores Islands (Portugal).". Meta gene (2014): http://europepmc.org/abstract/med/25606447.
    10.1016/j.mgene.2014.08.004
  32. "Urolithiasis Bioresource". Open Journal of Bioresources 1 (2014): e4-e4. http://dx.doi.org/10.5334/ojb.ad.
    10.5334/ojb.ad
  33. Armas, Jacome. "Effectiveness and safety of infliximab in two cases of severe chondrocalcinosis: nine years of follow-up.". Case reports in rheumatology (2014): http://europepmc.org/abstract/med/25436167.
    10.1155/2014/536856
  34. Helena Canhão; Ana Rodrigues; Maria Jose Santos; Diana Carmona-Fernandes; José Costa; Helena Santos; Jaime Branco; et al. "A7.16 Lack of Replication ofPTPRC Geneas a Predictor of Response to Anti-Tumour Necrosis Factor Therapy in Patients with Rheumatoid Arthritis". Annals of the Rheumatic Diseases 72 Suppl 1 (2013): A53.2-A53. https://doi.org/10.1136%2Fannrheumdis-2013-203221.16.
    10.1136/annrheumdis-2013-203221.16
  35. Mendes, S.A.C.; Mansoor, T.A.; Rodrigues, A.; Armas, J.B.; Ferreira, M.-J.U.. "Anti-inflammatory guaiane-type sesquiterpenes from the fruits of Pittosporum undulatum". Phytochemistry (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84880439780&partnerID=MN8TOARS.
    10.1016/j.phytochem.2013.06.019
  36. Díaz-Peña, R.; Castro-Santos, P.; Aransay, A.M.; Brüges-Armas, J.; Pimentel-Santos, F.M.; López-Larrea, C.. "Genetic study confirms association of HLA-DPA1*01:03 subtype with ankylosing spondylitis in HLA-B27-positive populations". Human Immunology 74 6 (2013): 764-767. http://www.scopus.com/inward/record.url?eid=2-s2.0-84877073967&partnerID=MN8TOARS.
    10.1016/j.humimm.2013.02.001
  37. Bettencourt, C.; Raposo, M.; Ros, R.; Montiel, R.; Bruges-Armas, J.; Lima, M.. "Transcript Diversity of Machado-Joseph Disease Gene (ATXN3) Is Not Directly Determined by SNPs in Exonic or Flanking Intronic Regions". Journal of Molecular Neuroscience 49 3 (2013): 539-543. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880628160&partnerID=MN8TOARS.
    10.1007/s12031-012-9832-3
  38. Bettencourt, B.F.; Rocha, F.L.; Alves, H.; Amorim, R.; Caetano-Lopes, J.; Vieira-Sousa, E.; Pimentel-Santos, F.; et al. "Protective effect of an ERAP1 haplotype in ankylosing spondylitis: Investigating non-MHC genes in HLA-B27-positive individuals". Rheumatology (United Kingdom) 52 12 (2013): 2168-2176. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887669101&partnerID=MN8TOARS.
    10.1093/rheumatology/ket269
  39. Armas, Jacome. "Contribution of the Portuguese Laboratory Network for the Diagnosis of Influenza A(H1N1)pdm09 infection during the 2009/10 and 2010/11 influenza seasons.". Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin (2012): http://europepmc.org/abstract/med/22790607.
  40. Canhão H; Rodrigues A; Santos MJ; Carmona-Fernandes D; Costa J; Santos H; Branco J; et al. "TRAF1/C5 locus is associated with response to anti-TNF in rheumatoid arthritis.". Journal of translational medicine (2012): http://europepmc.org/abstract/PMC/PMC3509112.
    10.1186/1479-5876-10-s3-p31
  41. Gruber, B.L.; Couto, A.R.; Armas, J.B.; Brown, M.A.; Finzel, K.; Terkeltaub, R.A.. "Novel ANKH amino terminus mutation (Pro5Ser) associated with early-onset calcium pyrophosphate disease with associated phosphaturia". Journal of Clinical Rheumatology 18 4 (2012): 192-195. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862206369&partnerID=MN8TOARS.
    10.1097/RHU.0b013e3182582c3d
  42. Díaz-Peña, R.; Aransay, A.M.; Suárez-Álvarez, B.; Bruges-Armas, J.; Rodríguez-Ezpeleta, N.; Regueiro, M.; Pimentel-Santos, F.M.; et al. "A high density SNP genotyping approach within the 19q13 chromosome region identifies an association of a CNOT3 polymorphism with ankylosing spondylitis". Annals of the Rheumatic Diseases 71 5 (2012): 714-717. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859501672&partnerID=MN8TOARS.
    10.1136/annrheumdis-2011-200661
  43. Bettencourt, C.; Raposo, M.; Kazachkova, N.; Santos, C.; Kay, T.; Vasconcelos, J.; MacIel, P.; et al. "Sequence analysis of 5' regulatory regions of the Machado-Joseph disease gene (ATXN3)". Cerebellum 11 4 (2012): 1045-1050. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870454416&partnerID=MN8TOARS.
    10.1007/s12311-012-0373-7
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  103. Acebes, C.; De La Piedra, C.; Traba, M.L.; Seibel, M.J.; Martín, C.G.; Armas, J.; Herrero-Beaumont, G.. "Biochemical markers of bone remodeling and bone sialoprotein in ankylosing spondylitis". Clinica Chimica Acta 289 1-2 (1999): 99-110. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032720862&partnerID=MN8TOARS.
    10.1016/S0009-8981(99)00170-9
  104. Bruges-Armas, J.; Martinez-Laso, J.; Martins, B.; Allende, L.; Gomez-Casado, E.; Longas, J.; Varela, P.; Gonzalez-Granado, M.; Arnaiz-Villena, A.. "HLA in the Azores Archipelago: Possible presence of Mongoloid genes". Tissue Antigens 54 4 (1999): 349-359. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032824817&partnerID=MN8TOARS.
    10.1034/j.1399-0039.1999.540404.x
  105. Ismail, A.A.; O'Neill, T.W.; Cooper, C.; Finn, J.D.; Bhalla, A.K.; Cannata, J.B.; Delmas, P.; et al. "Mortality associated with vertebral deformity in men and women: Results from the European Prospective Osteoporosis Study (EPOS)". Osteoporosis International 8 3 (1998): 291-297. http://www.scopus.com/inward/record.url?eid=2-s2.0-7344223260&partnerID=MN8TOARS.
    10.1007/s001980050067
  106. Reeve, J.; Silman, A.J.; Agnusdei, D.; Banzer, D.; Benevolenskaya, L.I.; Bhalla, A.; Armas, J.B.; et al. "The European prospective osteoporosis study". Osteoporosis International 6 SUPPL. 3 (1996): 16-18. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029856827&partnerID=MN8TOARS.
  107. Armas, Jacome. "Psoriatic arthritis: outcome of disease subsets and relationship of joint disease to nail and skin disease.". British journal of rheumatology (1994): http://europepmc.org/abstract/med/8081668.
    10.1093/rheumatology/33.9.834
  108. Armas, Jacome. "The cervical spine in psoriatic arthritis: a clinical and radiological study.". British journal of rheumatology (1994): http://europepmc.org/abstract/med/8156288.
    10.1093/rheumatology/33.3.255
  109. Armas, Jacome. "Atypical Behçet's disease with peripheral erosive arthropathy and pyoderma gangrenosum.". Clinical and experimental rheumatology (1992): http://europepmc.org/abstract/med/1505112.
  110. Armas, Jacome. "Limited forms of Wegener's granulomatosis presenting as polymyalgia rheumatica.". British journal of rheumatology (1991): http://europepmc.org/abstract/med/1913011.
    10.1093/rheumatology/30.5.382
  111. Armas, Jacome. "Selective IgA deficiency and spondyloarthropathy: a distinct disease?". Annals of the rheumatic diseases (1990): http://europepmc.org/abstract/med/2396872.
    10.1136/ard.49.8.636
  112. Armas, Jacome. "Postsalmonella reactive phenomena in 2 patients with ankylosing spondylitis: no modification of the underlying disease.". The Journal of rheumatology (1990): http://europepmc.org/abstract/med/2181129.
  113. Herrero-Beaumont, G.; Armas, J.B.; Amorin, R.; Quiros, J.; Bhalla, A.K.. "Polymalgia rheumatica: A study of 106 cases with special referencia to articular manifestations,POLIMIALGIA REUMATICA. ESTUDIO DE 106 CASOS CON ESPECIAL REFERENCIA A LAS MANIFESTACIONES ARTICULARES". Revista Espanola de Reumatologia 17 3 (1990): 92-97. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024989364&partnerID=MN8TOARS.
  114. Herrero-Beaumont, G.; Zarco, P.; Armas, J.; Calin, A.. "Immunoglobulin A deficiency is a poor prognosis factor in the course of Reiter's syndrome,EL DEFICIT DE IgA ES UN FACTOR DE MAL PRONOSTICO EN LA EVOLUCION DEL SINDROME DE REITER". Revista Espanola de Reumatologia 16 6 (1989): 162-163. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024850685&partnerID=MN8TOARS.
  115. Armas, Jacome. "[Mauriac syndrome. Apropos of a clinical case]". Acta medica portuguesa (1986): http://europepmc.org/abstract/med/3661246.
Newspaper article
  1. Lima, Manuela; Raposo, Mafalda; Armas, Jácome Bruges; Vasconcelos, João. "Doença de Machado-Joseph à procura de biomarcadores moleculares", 2013, http://hdl.handle.net/10400.3/5520.
  2. Bettencourt, Bruno; Rocha, Fabiana; Martinho, Antonio; F. M. Pimentel-Santos; Alves, Helena; Branco, J; Fonseca, João Eurico; Amorim, Rosa; Armas, Jacome. "Ankylosing spondylitis and IL23R-preliminary results", Tissue Antigens , 2010
Thesis / Dissertation
  1. Amaro, Bruna da Conceição Correia Parreira. "Genetic variants associated with ectopic calcifications". PhD, Universidade do Algarve, 2018. http://hdl.handle.net/10400.1/10816.
  2. "New markers, prevalence and burden of osteoporosis and fragility fractures". PhD, 2018. http://hdl.handle.net/10451/38062.
  3. Parreira, Bruna da Conceição Correia. "Biobanco “AZORBIO”: organização de recursos biológicos para a investigação". Master, 2013. http://hdl.handle.net/10400.3/1653.
  4. "Genetics of ankylosing spondylitis-Contribution to the understading of the understading of the immnopathogenesis of the disease through the study of non-hla genes". PhD, Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, 2013.
  5. "Estudo Epidemiológico do Cancro do Pulmão no Hospital de Santo Espírito da Ilha Terceira entre 2002 e 2012". Master, 2013. https://hdl.handle.net/10216/71910.
  6. Mendes, Sofia Alexandra Carreiro. "Study of the anti-inflamatory and antitumoral activities of the fruits of Pittosporum undulatum Vent.". Master, 2012. http://hdl.handle.net/10451/11232.
  7. Freitas, Ana Margarida de Lima. "Caracterização fenotípica e genotípica de doentes açorianos com Espondilite Anquilosante". Master, Universidade dos Açores, 2011. http://hdl.handle.net/10400.3/1182.
  8. "Genetics and epidemiology of ectopic calcification.". PhD, 2011. http://hdl.handle.net/10216/54257.
  9. Dutra, Isa Catarina Fernandes, 1982-. "Aspectos moleculares do cancro do colo do útero". Master, 2010. http://hdl.handle.net/10451/2759.
  10. "Avaliação nutricional do doente oncológico pela AGS-GD". Master, Universidade do Porto Faculdade de Ciências da Nutrição e Alimentação, 2008.
  11. "Genética do suicídio : genes envolvidos no metabolismo das catecolaminas". Master, Universidade de Coimbra Faculdade de Medicina, 2008.
  12. "Microsatellite instability in colorectal cancer from Azorean patients". Master, Universidade do Minho, 2007.
  13. "Estudo da Associação entre alelos e haplótipos HLA-Classe II e a Retinopatia Diabética". Degree, Universidade dos Açores - Campus de Angra do Heroísmo, 2007.
  14. "Incidência do Cancro na Região Autónoma dos Açores 1998 - 2002. Ilhas dos Grupos Central e Ocidental". Master, Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, 2006.
  15. "Contribuição da via do poliol no desenvolvimento da Retinopatia Diabética". Degree, Universidade dos Açores - Campus de Angra do Heroísmo, 2005.

Other

Other output
  1. Spondyloarthritis, Diffuse Idiopathic Skeletal Hyperostosis (DISH) and Chondrocalcinosis. 2009. Jácome Brugues Armas; Ana Rita Couto; Bruno Filipe Bettencourt. https://doi.org/10.1007%2F978-1-4419-0298-6_3.
    10.1007/978-1-4419-0298-6_3
  2. 13 th IHWSDisease Component Joint Report. D7 The 13 th International Histocompatibility Working Group for Spondyloarthropathies Joint Report. 2006.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2016 Diffuse Idiopathic Skeletal Hyperostosis (DISH) 1st Investigators Workshop Meeting Tel Aviv 20-23 May 2016
(Tel Aviv, Israel)
2011/12/13 AZORES Biobank
(Lisbon, Portugal)
2009/11/21 Molecular Biology - Genetics of Cartilage 1st Course . Study Group on Cartilage, Prevention and Treatment of Arthrosis.
Portuguese Society for Orthopedics and Traumatology (Lisbon, Portugal)
2009/06/27 Molecular Genetics of Ankylosing Spondylitis II Simposium - Biologic Therapy of Autoimmune Diseases NEDAI
(Portugal)
2007/10/24 Retinopatia Diabética nos Açores: A Genética e o Prognóstico X Congresso de Endocrinologia e Nutrição dos Açores
Portuguese Society for Endocrinology (Ponta Delgada, Portugal)
2007/02 The Genetics of Ankylosing Spondylitis Iº Biomedical Meeting - The Genetics of Complex Diseases
University of Azores (Ponta Delgada, Portugal)
2005/09/23 Investigação na Saúde - Necessidade ou Obrigação". Lecture of the Opening Session of the Academic Year
University of Azores (Ponta Delgada, Portugal)
2005 Son la hiperostosis anquilosante y la condrocalcinosis la misma enfermedad XIII Symposio sobre Inflamación. Léon, Espanha
(Leon, Spain)
2003/10/26 Clinical, radiographic and genetic characteristics of familial DISH/CC in the Azores American College Rheumatology (ACR/ARHP) Anual Scientific Meeting
(United States)
2001 Estudio de las migraciones de los povos en Azores y su impronta en los subtipos del HLA-B27 y en las Espondilartritis Symposio Anual del Comité Iberoamericano de Reumatologia (CIAR)
(Sevilha, Spain)
1996 Osteoporose como proceso ligado a las Espondiloartritis XXII Congresso Nacional da Sociedade Espanhola de Reumatologia
(Spain)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023 - Current Epidemiologia, fatores de risco e agregação familiar da osteoartrose avançada da anca e joelho: a realidade da ilha Terceira
Supervisor
Universidade dos Açores, Portugal
2019 - Current Investigating the association of fluoride in drinking water in the epidemiology of skeletal ectopic calcifications and bone fragility in Portugal (FLEPIPORT)
Supervisor
Universidade do Porto, Portugal
2013 - 2018 Genetic variants associated with ectopic calcifications
Supervisor
 Biotechnological sciences (PhD)
Universidade do Algarve - Campus de Gambelas, Portugal
2011 - 2015 Genetics of ankylosis spondylitis
Supervisor
2010 - 2013 Estudo Epidemiológico do Cancro do Pulmão no Hospital de Santo Espírito da Ilha Terceira entre 2002 e 2012
Co-supervisor
 Ciências médicas e da saúde (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2007 - 2013 Genética da Espondilite Anquilosante - contribuição para o estudo da imunopatogénese da doença através do estudo de genes não HLA
Supervisor
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2010 - 2012 Biobanco AZORBIO: Organização de recursos biológicos para a investigação
Supervisor
 Biomedical sciences (Master)
Universidade dos Açores, Portugal
2010 - 2012 Study of the anti-inflamatory and antitumoral activities of the fruits of Pittosporum undulatum
Supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2009 - 2011 Caracterização fenotípica e genotípica de doentes açorianos com Espondilite Anquilosante
Supervisor
 Biomedicine (Master)
Universidade dos Açores, Portugal
2009 - 2010 Aspectos Moleculares do Carcinoma do Colo do Útero nos Açores
Supervisor
Universidade de Lisboa Faculdade de Ciências, Portugal
2009 - 2010 Caracterização das Células Mesenquimatosas Estaminais em Doentes com DISH / Condrocalcinose
Supervisor
2008 - 2009 Avaliação nutricional do doente oncológico pela AGS-GD
Supervisor
 Ciências da Nutrição (Master)
Universidade do Porto, Portugal
2003 - 2009 Genetic and Epidemiologic Studies on Ectopic Calcifications
Co-supervisor
Universidade do Porto, Portugal
2005 - 2008 Genética do suicídio : genes envolvidos no metabolismo das catecolaminas
Supervisor
Universidade de Coimbra, Portugal
2006 - 2007 Estudo da Associação entre alelos e haplótipos HLA-Classe II e a Retinopatia Diabética
Supervisor
 Biotechnology (Degree)
Universidade dos Açores - Campus de Angra do Heroísmo, Portugal
2006 - 2007 Microsatellite instability in colorectal cancer from Azorean patients
Supervisor
 Molecular Genetic (Master)
Universidade do Minho, Portugal
2005 - 2006 Incidência do Cancro na Região Autónoma dos Açores 1998 - 2002. Ilhas dos Grupos Central e Ocidental
Supervisor
 Oncology (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2004 - 2005 Contribuição da via do poliol no desenvolvimento da Retinopatia Diabética
Supervisor
 Biotechnology (Degree)
Universidade dos Açores - Campus de Angra do Heroísmo, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2011/04/29 - 2011/04/30 "Epidemiologia da epilepsia pediátrica" (2011/04/29 - 2011/04/30)
Seminar (President of the Organising Committee)
 Hospital de Santo Espírito da Ilha Terceira, EPER- Serviço Especializado de Epidemiologia e Biologia Molecular, Portugal
2007/06/15 - 2007/06/15 "Diabetes mellitus - aspeto clínicos e genéticos" (2007/06/15 - 2007/06/15)
Seminar (President of the Organising Committee)
 Hospital de Santo Espírito da Ilha Terceira, EPER- Serviço Especializado de Epidemiologia e Biologia Molecular, Portugal
2005/06/27 - 2005/06/27 "Genética da espondilartrite- sistema HLA e sua contribuição para a investigação clínica e antropológica nos arquipélagos da Macaronésia". (2005/06/27 - 2005/06/27)
Seminar (President of the Organising Committee)
 Hospital de Santo Espírito da Ilha Terceira, EPER- Serviço Especializado de Epidemiologia e Biologia Molecular, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2018 Genetic variants associated with ectopic calcifications
Supervisor
 Bruna da Conceição Correia Parreira (PhD)
Universidade do Algarve - Campus de Gambelas, Portugal
2013 Genética da Espondilite Anquilosante - contribuição para o estudo da imunopatogénese da doença através do estudo de genes não HLA
Supervisor
 Bruno Bettencourt (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2012 Biobanco AZORBIO: Organização de recursos biológicos para a investigação
Supervisor
 Bruna da Conceição Correia Parreira (Master)
Universidade dos Açores, Portugal
2011 Caracterização fenotípica e genotípica de doentes açorianos com Espondilite Anquilosante
Supervisor
 Ana Freitas (Master)
Universidade dos Açores, Portugal
2011 Effect of Inflammation on Bone Biological, Structural and Mechanical Behaviour
(Thesis) Main arguer
 Joana Caetano Lopes (PhD)
Universidade de Lisboa, Portugal
2011 Doença de Machado-Joseph : análise da região 3'UTR do gene ATXN3
(Thesis) Arguer
 Marta do Rosário Cristino Silva Ventura (Master)
Universidade dos Açores, Portugal
2010 Aspectos Moleculares do Carcinoma do Colo do Útero nos Açores
Supervisor
 Isa Dutra (Master)
Universidade de Lisboa, Portugal
2010 Influencia de las Regiones MHC (6p21) y LRC (19q13.4) en la Susceptibilidad a Espondilitis Anquilosante
(Thesis) Main arguer
 Roberto Diaz Peña (PhD)
Universidad de Oviedo, Spain
2009 Genetic and Epidemiologic Studies on Ectopic Calcifications
Supervisor
 Ana Rita Couto (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2009 Machado-Joseph disease: from genetic variability to clinical heterogeneity
(Thesis) Main arguer
 Conceição Bettencourt (PhD)
Universidade dos Açores, Portugal
2008 Genética do suicídio : genes envolvidos no metabolismo das catecolaminas
Supervisor
 Carla Fernandes (Master)
Centro Hospitalar e Universitario de Coimbra EPE Centro de Simulação Biomédica dos Hospitais da Universidade de Coimbra, Portugal
2008 Avaliação nutricional do doente oncológico pela AGS-GD
Supervisor
 Débora Silveira (Master)
Universidade do Porto, Portugal
2007 Microsatellite instability in colorectal cancer from Azorean patients
Supervisor
 Maria José Peixoto (Master)
Universidade do Minho, Portugal
2007 Influencia del polimorfismo HLA-B27 en el procesamiento antigénico de la molécula: implicaciones patogénicas en el desarrollo de las espondiloartropatias.
(Thesis) Main arguer
 Miguel Angel Blanco Gelaz (PhD)
Fundación Universidad de Oviedo, Spain
2005 Diversidade Genética do Sistema HLA em Portugal, Cabo Verde e Guin´-Bissau
Thesis Member
 Hélder Spínola de Freitas (PhD)
Universidade da Madeira, Portugal

Association member

Society Organization name Role
1992 - 2002 British Society for Rheumatology.

Committee member

Activity description
Role 		Institution / Organization
2011 - 2018 Linking WNT Pathway with Bone Mineralization, Mechanical Properties and Fracture Risk in Osteoporosis
Member
 Universidade de Lisboa, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2014 - 2016 Member of the evaluation group for Clinical Medicine and Health Sciences to evaluate PhD and Pos-Doc projects.
Evaluator
 Fundação para a Ciência e a Tecnologia, Portugal

Journal scientific committee

Journal title (ISSN) Publisher
2021/03/09 - Current BMC Musculoskeletal Disorders Springer

Other jury / evaluation

Activity description Institution / Organization
2022 - 2022 Bolsas Terry Fox- Liga Portuguesa Contra o Cancro Liga Portuguesa Contra o Cancro, Portugal
2013 - 2014 Painel de Medicina Clínica e Ciências da Saúde- Concursos FCT de bolsas individuais de Doutoramento e Pós- Doutoramento Fundação para a Ciência e a Tecnologia, Portugal
Distinctions

Other distinction

2018 Investigating the association of fluoride in drinking water in the pedidemiology of skeletal ectopic calcifications and bone fragility in Portugal
Sociedade Portuguesa de Reumatologia, Portugal
2017 TRAF1/C5 but not PTPRC variants are potential predictors of rheumatoid arthritis response to anti-tumor necrosis factor therapy
Sociedade Portuguesa de Reumatologia, Portugal