Ana Rute de Azevedo Pina Neves (A51A-E760-E8B8)

Curriculum Vitae

Ana Rute de Azevedo Pina Neves

Identification

Personal identification

Full name: Ana Rute de Azevedo Pina Neves

Citation names

Neves, Ana Rute

Author identifiers

Ciência ID: A51A-E760-E8B8
ORCID iD: 0000-0003-4262-5837

Education

	Degree	Classification
2015 Concluded	Ciências Farmacêuticas (Doutoramento) Major in Especialidade: Química Farmacêutica e Medicinal Universidade do Porto Faculdade de Farmácia, Portugal "A membrane biophysical approach to the therapeutic effects of resveratrol and design of novel nutraceutical nanoformulations." (THESIS/DISSERTATION)

Projects

Grant

	Designation	Funders
2017 - Current	CQM+ M1420-01-0145-FEDER-000005 – Centro de Química da Madeira – CQM+	Região Autónoma da Madeira
2016 - 2017	Qualidade e Segurança Alimentar — uma abordagem (nano) tecnológica NORTE-01-0145-FEDER-000011	Governo de Portugal
2011 - 2015	"A membrane biophysical approach to the therapeutic effects of resveratrol and design of novel nutraceutical nanoformulations" SFRH/BD/73379/2010	Fundação para a Ciência e a Tecnologia
2009 - 2009	"Spectroscopic and Computational Studies of the Catalytic Mechanism of Nitrate Reductase" PTDC/QUI/67052/2006	Fundação para a Ciência e a Tecnologia

Contract

	Designation	Funders
2019 - Current	“NanoLact50+ - Nanotech-functional dairy foods for healthy aging” 02/SAICT/2017/032302/T496166614-00039289	Fundação para a Ciência e a Tecnologia
2018 - Current	“A nanotechnological approach for topical administration of insulin for wound healing” PTDC/MEC-DER/32610/2017	Fundação para a Ciência e a Tecnologia
2018 - Current	“BLUEHUMAN - BLUE biotechnology as a road for innovation on HUMAN’s health aiming smart growth in Atlantic Area” EAPA-151/2016	European Regional Development Fund
2018 - Current	“NANO-TB Nanomedicine as a multifunctional platform for the treatment of drug-sensitive and multidrug resistant tuberculosis” POCI-01-0145-FEDER-30624	Fundação para a Ciência e a Tecnologia
2016 - Current	“Navigating through marine-derived fungi: bioprospection and synthesis of bioactive secondary metabolites and analogues as chemotherapic agents” PTDC/MAR-BIO/4694/2014	Fundação para a Ciência e a Tecnologia
2018/07/01 - 2022/06/30	Nanomedicina como plataforma multifuncional para o tratamento de tuberculose sensível e multi-resistente a fármacos PTDC/BTM-MAT/30624/2017 Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal Universidade do Porto, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2019/01/01 - 2019/12/31	Centro de Química da Madeira UID/QUI/00674/2019 Universidade da Madeira, Portugal Universidade da Madeira Centro de Química da Madeira, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2019/01/01 - 2019/12/31	Unidade de Ciências Biomoleculares Aplicadas UID/Multi/04378/2019 Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal Unidade de Ciências Biomoleculares Aplicadas, Portugal Associação para a Inovação e Desenvolvimento da FCT, Portugal Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal Universidade do Porto Faculdade de Ciências, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Outputs

Publications

Journal article

Rúben G. R. Pinheiro; Ana Joyce Coutinho; Marina Pinheiro; Ana Rute Neves. "Nanoparticles for Targeted Brain Drug Delivery: What Do We Know?". International Journal of Molecular Sciences (2021): https://doi.org/10.3390/ijms222111654.
10.3390/ijms222111654
Rúben G. R. Pinheiro; Marina Pinheiro; Ana Rute Neves. "Nanotechnology Innovations to Enhance the Therapeutic Efficacy of Quercetin". Nanomaterials (2021): https://doi.org/10.3390/nano11102658.
10.3390/nano11102658
João Albuquerque; Susana Casal; Rebeca Cruz; Ingrid Van Dorpe; Margarida Rosa Garcez Maia; António José Mira Fonseca; Ana Rita Jordão Cabrita; Ana Rute Neves; Salette Reis. "Validation of a Simple HPLC-Based Method for Lysine Quantification for Ruminant Nutrition". Molecules 26 14 (2021): 4173-4173. https://doi.org/10.3390/molecules26144173.
10.3390/molecules26144173
R.G.R. Pinheiro; A. Granja; J.A. Loureiro; M.C. Pereira; M. Pinheiro; A.R. Neves; S. Reis. "RVG29-Functionalized Lipid Nanoparticles for Quercetin Brain Delivery and Alzheimer’s Disease". Pharmaceutical Research 37 7 (2020): https://doi.org/10.1007/s11095-020-02865-1.
10.1007/s11095-020-02865-1
R.G.R Pinheiro; A Granja; J.A Loureiro; M.C Pereira; M Pinheiro; A.R Neves; S Reis. "Quercetin lipid nanoparticles functionalized with transferrin for Alzheimer's disease". European Journal of Pharmaceutical Sciences 148 (2020): 105314-105314. https://doi.org/10.1016/j.ejps.2020.105314.
10.1016/j.ejps.2020.105314
Granja, A.; Neves, A.R.; Sousa, C.T.; Pinheiro, M.; Reis, S.. "EGCG intestinal absorption and oral bioavailability enhancement using folic acid-functionalized nanostructured lipid carriers". Heliyon 5 7 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85068239916&partnerID=MN8TOARS.
10.1016/j.heliyon.2019.e02020
Granja, A.; Frias, I.; Neves, A.R.; Pinheiro, M.; Reis, S.. "Therapeutic Potential of Epigallocatechin Gallate Nanodelivery Systems". BioMed Research International 2017 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85027178920&partnerID=MN8TOARS.
10.1155/2017/5813793
Granja, A.; Vieira, A.C.; Chaves, L.L.; Nunes, C.; Neves, A.R.; Pinheiro, M.; Reis, S.. "Folate-targeted nanostructured lipid carriers for enhanced oral delivery of epigallocatechin-3-gallate". Food Chemistry 237 (2017): 803-810. http://www.scopus.com/inward/record.url?eid=2-s2.0-85020422359&partnerID=MN8TOARS.
10.1016/j.foodchem.2017.06.019
Neves, A.R.; Queiroz, J.F.; Lima, S.A.C.; Reis, S.. "Apo E-Functionalization of Solid Lipid Nanoparticles Enhances Brain Drug Delivery: Uptake Mechanism and Transport Pathways". Bioconjugate Chemistry 28 4 (2017): 995-1004. http://www.scopus.com/inward/record.url?eid=2-s2.0-85018511957&partnerID=MN8TOARS.
10.1021/acs.bioconjchem.6b00705
Loureiro, J.A.; Andrade, S.; Duarte, A.; Neves, A.R.; Queiroz, J.F.; Nunes, C.; Sevin, E.; et al. "Resveratrol and grape extract-loaded solid lipid nanoparticles for the treatment of Alzheimer's disease". Molecules 22 2 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85013157937&partnerID=MN8TOARS.
10.3390/molecules22020277
Neves, A.R.; Nunes, C.; Reis, S.. "Resveratrol induces ordered domains formation in biomembranes: Implication for its pleiotropic action". Biochimica et Biophysica Acta - Biomembranes 1858 1 (2016): 12-18. http://www.scopus.com/inward/record.url?eid=2-s2.0-84949009364&partnerID=MN8TOARS.
10.1016/j.bbamem.2015.10.005
Neves, A.R.; Martins, S.; Segundo, M.A.; Reis, S.. "Nanoscale delivery of resveratrol towards enhancement of supplements and nutraceuticals". Nutrients 8 3 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84960096002&partnerID=MN8TOARS.
10.3390/nu8030131
Neves, A.R.; Nunes, C.; Amenitsch, H.; Reis, S.. "Resveratrol Interaction with Lipid Bilayers: A Synchrotron X-ray Scattering Study". Langmuir 32 48 (2016): 12914-12922. http://www.scopus.com/inward/record.url?eid=2-s2.0-85002822191&partnerID=MN8TOARS.
10.1021/acs.langmuir.6b03591
Neves, A.R.; Queiroz, J.F.; Costa Lima, S.A.; Figueiredo, F.; Fernandes, R.; Reis, S.. "Cellular uptake and transcytosis of lipid-based nanoparticles across the intestinal barrier: Relevance for oral drug delivery". Journal of Colloid and Interface Science 463 (2016): 258-265. http://www.scopus.com/inward/record.url?eid=2-s2.0-84946600781&partnerID=MN8TOARS.
10.1016/j.jcis.2015.10.057
Lopes-De-Araújo, J.; Neves, A.R.; Gouveia, V.M.; Moura, C.C.; Nunes, C.; Reis, S.. "Oxaprozin-Loaded Lipid Nanoparticles towards Overcoming NSAIDs Side-Effects". Pharmaceutical Research 33 2 (2016): 301-314. http://www.scopus.com/inward/record.url?eid=2-s2.0-84954368605&partnerID=MN8TOARS.
10.1007/s11095-015-1788-x
Barbosa, J.P.; Neves, A.R.; Silva, A.M.; Barbosa, M.A.; Salette Reis, M.; Santos, S.G.. "Nanostructured lipid carriers loaded with resveratrol modulate human dendritic cells". International Journal of Nanomedicine 11 (2016): 3501-3516. http://www.scopus.com/inward/record.url?eid=2-s2.0-84982733205&partnerID=MN8TOARS.
10.2147/IJN.S108694
Neves, A.R.; Queiroz, J.F.; Reis, S.. "Brain-targeted delivery of resveratrol using solid lipid nanoparticles functionalized with apolipoprotein E". Journal of Nanobiotechnology 14 1 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84962800287&partnerID=MN8TOARS.
10.1186/s12951-016-0177-x
Neves, A.R.; Nunes, C.; Amenitsch, H.; Reis, S.. "Effects of resveratrol on the structure and fluidity of lipid bilayers: A membrane biophysical study". Soft Matter 12 7 (2016): 2118-2126. http://www.scopus.com/inward/record.url?eid=2-s2.0-84958260311&partnerID=MN8TOARS.
10.1039/c5sm02905h
Frias, I.; Neves, A.R.; Pinheiro, M.; Reis, S.. "Design, development, and characterization of lipid nanocarriers-based epigallocatechin gallate delivery system for preventive and therapeutic supplementation". Drug Design, Development and Therapy 10 (2016): 3319-3528. http://www.scopus.com/inward/record.url?eid=2-s2.0-84994474541&partnerID=MN8TOARS.
10.2147/DDDT.S109589
Neves, A.R.; Nunes, C.; Reis, S.. "New Insights on the Biophysical Interaction of Resveratrol with Biomembrane Models: Relevance for Its Biological Effects". Journal of Physical Chemistry B 119 35 (2015): 11664-11672. http://www.scopus.com/inward/record.url?eid=2-s2.0-84941312936&partnerID=MN8TOARS.
10.1021/acs.jpcb.5b05419
Neves, A.R.; Reis, S.; Segundo, M.A.. "Development and Validation of a HPLC Method Using a Monolithic Column for Quantification of trans-Resveratrol in Lipid Nanoparticles for Intestinal Permeability Studies". Journal of Agricultural and Food Chemistry 63 12 (2015): 3114-3120. http://www.scopus.com/inward/record.url?eid=2-s2.0-84926289263&partnerID=MN8TOARS.
10.1021/acs.jafc.5b00390
Neves, A.R.; Queiroz, J.F.; Weksler, B.; Romero, I.A.; Couraud, P.-O.; Reis, S.. "Solid lipid nanoparticles as a vehicle for brain-targeted drug delivery: Two new strategies of functionalization with apolipoprotein e". Nanotechnology 26 49 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84947976708&partnerID=MN8TOARS.
10.1088/0957-4484/26/49/495103
Neves, A.R.; Lúcio, M.; Martins, S.; Lima, J.L.C.; Reis, S.. "Novel resveratrol nanodelivery systems based on lipid nanoparticles to enhance its oral bioavailability". International Journal of Nanomedicine 8 (2013): 177-187. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872351206&partnerID=MN8TOARS.
10.2147/IJN.S37840
Neves, A.R.; Lúcio, M.; Lima, J.L.C.; Reis, S.. "Resveratrol in medicinal chemistry: A critical review of its pharmacokinetics, drug-delivery, and membrane interactions". Current Medicinal Chemistry 19 11 (2012): 1663-1681. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860540855&partnerID=MN8TOARS.
10.2174/092986712799945085
Neves, A.R.; Fernandes, P.A.; Ramos, M.J.. "The accuracy of density functional theory in the description of cation-p and p-hydrogen bond interactions". Journal of Chemical Theory and Computation 7 7 (2011): 2059-2067. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960246616&partnerID=MN8TOARS.
10.1021/ct2001667
Sousa, S.F.; Cerqueira, N.M.F.S.A.; Perez, M.A.S.; Moreira, I.S.; Ribeiro, A.J.M.; Neves, A.R.A.P.; Ramos, M.J.; Fernandes, P.A.. "Recent advances on computational proteomics". World Academy of Science, Engineering and Technology 56 (2009): 376-386. http://www.scopus.com/inward/record.url?eid=2-s2.0-78651571830&partnerID=MN8TOARS.