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João M.A. Santos is an accomplished researcher with a wealth of experience in developing innovative therapies for non-communicable diseases. He holds a PhD in Regenerative Medicine and Mechanisms of Disease, and has made significant scientific contributions throughout his career. João currently works at the Center of Marine Sciences, where he uses zebrafish as a model to study orphan diseases and screen new drugs for cardiovascular, skeletal, and neurological disorders. In addition, João has extensive experience in stem cell and molecular biology and extracellular vesicles analysis. João has published nine papers with a cumulative impact factor of 58.5 and an H-index of 7. He has played a significant role in securing and implementing multiple national and international research projects, including serving as the lead principal investigator for one. He has supervised 13 researchers and students and has been helping with teaching at the University of Algarve since 2019. João has also engaged in various public outreach activities, such as science festivals and mentoring programs, and is a member of national and international research societies. João is highly regarded by his colleagues for his excellent communication and leadership skills. He takes great pride in his excellent oral and written scientific communication skills, which have earned him numerous awards. In addition to his scientific career, João gained valuable working experience in a bank, which provided him with a business perspective and soft skills that have proven beneficial in his scientific career.
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Identification

Personal identification

Full name
Joao Santos

Citation names

  • Santos, Joao
  • Joao M.A. Santos

Author identifiers

Ciência ID
B713-B787-0A9E
ORCID iD
0000-0002-1218-368X

Telephones

Mobile phone
  • 927654819 (Personal)

Addresses

  • Estrada Da Senhora Da Saude, N62 7dto, 8000-498, Faro, Faro, Portugal (Personal)

Knowledge fields

  • Natural sciences - Biological Sciences - Molecular Biology
  • Natural sciences - Biological Sciences - Cell Biology
  • Medical and Health Sciences - Medical Biotechnology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Intermediate (B1)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
2015/01/01 - 2019/06/12
Concluded
 Mecanismos de Doença e Medicina Regenerativa (Doutoramento)
Universidade Nova de Lisboa, Portugal

Universidade do Algarve, Portugal
"Cited2 in Cardiac Development: an inside and outside job " (THESIS/DISSERTATION)
 Approved with High Distinction and Honor
2019
Concluded
 Certificado de Competências Pedagógicas (Outros)
Instituto do Emprego e Formação Profissional, Portugal
2017
Concluded
 R Language (Pós-Graduação)
Universidade do Algarve, Portugal
2016
Concluded
 Animal experimentation FELASA cat. B (Outros)
SPCAL - Sociedade Portuguesa de Ciências em Animais de Laboratório, Portugal
2011/09/01 - 2013/11/22
Concluded
 Ciências Biomédicas (Mestrado integrado)
Universidade da Beira Interior, Portugal
"Development of nanoparticles for mitochondrial gene therapy" (THESIS/DISSERTATION)
 17
2008/09/01 - 2011/06/30
Concluded
 Ciências Biomédicas (Licenciatura)
Universidade da Beira Interior, Portugal
 15
2002 - 2007
Concluded
 Diplome D'etudes de langue Française (Outros)
Centro de Línguas , Portugal
2000 - 2007
Concluded
 Certificate in Advanced English (Outros)
Centro de Línguas , Portugal
Affiliation

Science

Category
Host institution 		Employer
2021/09/01 - Current Postdoc (Research) Centro de Ciências do Mar, Portugal
Centro de Ciências do Mar, Portugal
2019/10/01 - 2021/07/31 Postdoc (Research) Universitetet i Oslo, Norway
Norsk Center for Molekylærmedisin, Norway
2015/01/01 - 2019/06/12 Research Trainee (Research) Universidade do Algarve, Portugal
Universidade do Algarve Centro de Investigação em Biomedicina, Portugal
2014/01/15 - 2014/12/15 Research Trainee (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Biocant Associação de Transferência de Tecnologia, Portugal

Others

Category
Host institution 		Employer
2008/06/01 - 2008/08/30 Assistente Bancário Banco Santander Portugal, Portugal
Outputs

Publications

Conference paper
  1. Medeiros, Maria C. R.; Mestre, Ana L. G.; Inácio, Pedro M. C.; Santos, José M. L.; Araujo, Inês M.; Bragança, José; Biscarini, Fabio; Gomes, Henrique L.. "Performance assessment of polymer based electrodes for in vitro electrophysiological sensing: the role of the electrode impedance". 2016.
    10.1117/12.2237659
Conference poster
  1. Joao M.A. Santos. Corresponding author: Joao M.A. Santos. "Zebrafish models to study ectopic calcification and calcium as-sociated pathologies". Paper presented in European Crystal Network 2023, 2023.
  2. Joao M.A. Santos. Corresponding author: Joao M.A. Santos. "Zebrafish model to study mechanisms of calcium metabolism in elastin associated pathologies". Paper presented in Interdisciplinary Approaches in Fish Skeletal Biology 2022, 2022.
  3. Joao M.A. Santos. Corresponding author: Joao M.A. Santos. "Zebrafish model to study mechanisms of calcium metabolism in elastin associated pathologies". Paper presented in ABC Days 2022, 2022.
  4. Joao M.A. Santos. Corresponding author: Joao M.A. Santos. "Zebrafish model to study mechanisms of ectopic mineralization associated to elastinopathies". Paper presented in III III International Meeting of the Portuguese Society of Genetics, 2022.
  5. Abreu, Rita; Santos, João; Rodrigues, Carolina; Borges, Inês; Gavaia, Paulo J.; Laizé, Vincent; Cancela, M. Leonor.. "Can zebrafish be a good model to study the onset of ectopic calcifications associated to mutant elastin?". Paper presented in 19th Portugaliæ Genetica, 2022.
  6. Nascimento, Pedro; Santos, João; Gavaia, Paulo J.; Bensimon-Brito, Anabela; Stainier, Didier Y.R.; Laizé, Vincent; Cance. "Studies towards the generation of Keutel Syndrome zebrafish models". Paper presented in 19th Portugaliæ Genetica, 2022.
  7. João M.A. Santos, Inês Borges, Paulo J. Gavaia, M. Leonor Cancela1,2,3. "Study of a Zebrafish mutant for elastin: Contribution to the study of Keutel Syndrome". Paper presented in Sociedade Portuguesa de Genética Humana (SPGH) 2021, 2021.
  8. Santos JMA, Silva L, Afonso V, Lopes J, Martins G, Machado R, Cancela L, Futschik M, Sachinidis A , Gavaia P and Braganç. "Cited2 in cardiac development: an inside and outside job". Paper presented in Secretome With]Out[ Borders, 2018.
  9. Silva L, Santos JMA, Lopes J, Martins G, Cancela L, Gavaia P and Bragança J.. "Zebrafish as model to study Cited2-caused developmental defects". Paper presented in Secretome With]Out[ Borders, 2018.
  10. José Irio, João Santos and José Bragança. "Engineering of embryonic stem cells lines for the modulation of Cited2 expression through conditional RNA silencing or overexpression.". 2016.
Journal article
  1. João M.A. Santos; Vincent Laizé; Paulo Gavaia; Natércia Conceição; M. Leonor Cancela. "Zebrafish Models to Study Ectopic Calcification and Calcium-Associated Pathologies". International Journal of Molecular Sciences (2023): https://www.mdpi.com/1422-0067/24/4/3366.
    10.3390/ijms24043366
  2. Arjmandi, Hamidreza; Rudsari, Hamid Khoshfekr; Santos, Joao; Zoofaghari, Mohammad; Ievglevskyi, Oleksandr; Kanada, Masamitsu; Khaleghi, Ali; Balasingham, Ilangko; Veletic, Mladen. "Extracellular Vesicle-Mediated Communication Nanonetworks: Opportunities and Challenges". IEEE Communications Magazine 59 5 (2021): 68-73. http://dx.doi.org/10.1109/mcom.001.2000994.
    10.1109/mcom.001.2000994
  3. Santos, João M. A.; Mendes-Silva, Leonardo; Afonso, Vanessa; Martins, Gil; Machado, Rui S. R.; Lopes, João A.; Cancela, Leonor; et al. "Exogenous WNT5A and WNT11 proteins rescue CITED2 dysfunction in mouse embryonic stem cells and zebrafish morphants". Cell Death & Disease 10 8 (2019): http://dx.doi.org/10.1038/s41419-019-1816-6.
    10.1038/s41419-019-1816-6
  4. Bragança, José; Lopes, João André; Mendes-Silva, Leonardo; Santos, João Miguel Almeida. "Induced pluripotent stem cells, a giant leap for mankind therapeutic applications". World Journal of Stem Cells 11 7 (2019): 421-430. http://dx.doi.org/10.4252/wjsc.v11.i7.421.
    10.4252/wjsc.v11.i7.421
  5. Charneca, João; Matias, Ana Catarina; Escapa, Ana Luisa; Fernandes, Catarina; Alves, André; Santos, João M.A.; Nascimento, Rita; Bragança, José. "Ectopic expression of CITED2 prior to reprogramming, promotes and homogenises the conversion of somatic cells into induced pluripotent stem cells". Experimental Cell Research 358 2 (2017): 290-300. http://dx.doi.org/10.1016/j.yexcr.2017.07.002.
    10.1016/j.yexcr.2017.07.002
  6. Inacio, Pedro M. C.; Mestre, Ana L. G.; de Medeiros, Maria do Carmo Raposo; Asgarifar, Sanaz; Elamine, Youssef; Canudo, Joana; Santos, Joao M. A.; et al. "Bioelectrical Signal Detection Using Conducting Polymer Electrodes and the Displacement Current Method". IEEE Sensors Journal 17 13 (2017): 3961-3966. http://dx.doi.org/10.1109/jsen.2017.2703834.
    10.1109/jsen.2017.2703834
  7. Pacheco-Leyva I; Matias AC; Oliveira DV; Santos JM; Nascimento R; Guerreiro E; Michell AC; et al. "CITED2 Cooperates with ISL1 and Promotes Cardiac Differentiation of Mouse Embryonic Stem Cells.". (2016): http://europepmc.org/abstract/med/27818139.
    10.1016/j.stemcr.2016.10.002
  8. Santos, Joao. "Is CITED2 a general regulator of stem cell functions?". Stem Cell and Translational Investigation (2015): http://dx.doi.org/10.14800/scti.755.
    10.14800/scti.755
  9. Santos J; Sousa F; Queiroz J; Costa D. "Rhodamine based plasmid DNA nanoparticles for mitochondrial gene therapy.". (2014): http://europepmc.org/abstract/med/24967548.
    10.1016/j.colsurfb.2014.06.003
Thesis / Dissertation
  1. "Cited2 in cardiac development: an inside and outside job". PhD, 2019.
  2. "Gene therapy: development of a new nanocarrier system for mitochondrial gene therapy". Master, 2013.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022/12/23 Zebrafish models to study ectopic mineralization disorders and calcium-associated pathologies Calcification disorders: from mechanisms to therapeutic strategies 2022
(Nancy, France)
2019/03/03 Cited2 in Cardiac Development III Jornadas do ABC
Algarve Biomedical Center (Quarteira, Portugal)
2018/06/15 Role of CITED2 in early stages of cardiac commitment of embryonic stem cells 2as Jornadas do ABC
Algarve Biomedical Center (Olhão, Portugal)
2017/10/12 Early Cardiogenic Events of Pluripotent Stem Cells 10th SPCE-TC Meeting
Sociedade Portuguesa de Células Estaminais e Terapias Celulares (Covilhã, Portugal)
2017/09/08 Role of Cited2 in Early Cardiogenic Events of Pluripotent Stem Cells 2nd CBMR/ProRegeM Annual Meeting
Centre for Biomedical Research (Faro, Portugal)
2017/02/04 Role of Cited2 in Early Cardiogenic Events of Pluripotent Stem Cells 2nd Heart Without Borders
Heart Without Borders (Coimbra, Portugal)
2016/07/01 Understanding the role of Cited2 during cardiac differentiation of mouse Embryonic Stem Cells 1st CBMR/ProRegeM Annual Meeting
Centre for Biomedical Research (Faro, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2022/01/15 - 2023/01 Understanding the pathophysiology of Keutel syndrome: A path towards cure
Supervisor
Centro de Ciências do Mar, Portugal
2021/09 - 2023/01 Study of the Matrix Gla Protein (MGP) loss-of-function in the zebrafish model - Contribution to the Keutel Syndrome project
Supervisor
 Biotecnologia (Master)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2021 - 2022 Role of Elastin in Cartilage Calcification caused by the decrease of Mgp function
Co-supervisor
 Genética Clínica Laboratorial (Master)
Universidade de Coimbra, Portugal
2018 - 2018 Reprogramação de células humanas de doentes de Fabry com os Fatores de Yamanaka e Cited2
Co-supervisor
 Biotecnologia (Degree)
Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2017 - 2017 Avaliação do potencial cardiogénico da sobre-expressão de Cited2 a várias etapas da diferenciação das células estaminais embrionárias
Co-supervisor
 Ciências Biomédicas (Degree)
Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2016 - 2016 Engineering of embryonic stem cells lines for the modulation of Cited2 expression through conditional RNA silencing or overexpression of flag-Cited2.
Co-supervisor
 Ciências Biomédicas (Degree)
Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2016 - 2016 Caracterização de células estaminais embrionárias de ratinho heterozigóticas para o gene CITED2
Co-supervisor
 Medicina (Master)
Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2022/11/09 - 2022/11/12 Interdisciplinary Approaches in Fish Skeletal Biology 2022 Sixth Conference: Interdisciplinary Approaches in Fish Skeletal Biology, Olhão, Algarve, Portugal. November 9-12 (2022/11/09 - 2022/11/12)
Congress (Member of the Organising Committee)
 Centro de Ciências do Mar, Portugal
2018 - 2018 3rd CBMR/ProRegeM Annual Meeting (2018 - 2018)
Meeting (Member of the Organising Committee)
 Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2018 - 2018 4th CBMR/ProRegeM Annual Meeting (2018 - 2018)
Meeting (Member of the Organising Committee)
 Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2016 - 2016 2nd CBMR/ProRegeM Annual Meeting (2016 - 2016)
Meeting (Member of the Organising Committee)
 Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2015 - 2015 1st CBMR/ProRegeM Annual Meeting (2015 - 2015)
Meeting (Member of the Organising Committee)
 Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2010 - 2010 2as Jornadas Nacionais de Ciências Biomédicas (2010 - 2010)
Congress (Member of the Organising Committee)
 Universidade da Beira Interior, Portugal

Ad Hoc journal article review

Journal title (ISSN) Publisher
2022/02 - Current Cells (2073-4409) mdpi
2021/11 - Current Environmental Science and Pollution Research (1614-7499) Springer

Association member

Society Organization name Role
2009/06/01 - 2011/06/01 Nucleo de estudantes de Ciências Biomédicas da Universidade da Beira Interior Departamento de Comunicação

Committee member

Activity description
Role 		Institution / Organization
2015/06/01 - 2018/06/01 Comissão de Doutorandos da Universidade do Algarve
Member
 Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2016/04/01 - 2018/03/01 Membro da Comissão Pedagógica
Member
 Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal

Consulting

Activity description Institution / Organization
2022/01 - Current Programa Mentoria - UALG Universidade do Algarve, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2021 - 2022 Eukaryotic Molecular Genetics (1st semester) Biologia Molecular e Microbiana (Mestrado) Universidade do Algarve, Portugal
2021/11 - 2021/11 BIOMEDAQU PHD Training School Program Biomedaqu PhD Program (Doctor of Philosophy) Universidade do Algarve, Portugal
2018 - 2019 Stem Cell Biology (1st Semester) Ciências Biomédicas (Mestrado) Universidade do Algarve, Portugal
Distinctions

Award

2020 The Blix Family Fund for Promoting Medical Research Award
2019 IMFAHE International Mentor Program awardee
2018 Famelab Semifinalist
2018 Best Oral presentation at 2nd Algarve Biomedical Center Congress
2018 Best poster award of 1 st Secretome Without Borders
2017 Bursary to the attendance of VIII Sociedade Portuguesa de Células Estaminais e Terapias Celulares (SPCE-TC)
2017 Bursary to the attendance of II Heart Without Borders
2014 PhD Scholarship Grant