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FILIPE JOSÉ MENEZES MERGULHÃO. Completed the PhD in Chemical Engineering in 2002 by Universidade de Lisboa/Instituto Superior Técnico and the degree Chemical Engineering in 1998 (5 year program) by Universidade de Lisboa/Instituto Superior Técnico. Is an Associate Professor in Universidade do Porto/Faculdade de Engenharia and Researcher in Universidade do Porto Laboratorio de Engenharia de Processos Ambiente Biotecnologia e Energia. Published more than 130 articles in international journals and has 13 book chapters. Supervised 7 PhD thesis and co-supervised 2.. Supervised 8 MSc dissertation(s). Has received 1 awards and/or honors. Participates and/or participated as Principal investigator in 7 project(s) and as a Researcher in 25 project(s). Works in the area(s) of Natural sciences with emphasis on Biological Sciences , Engineering and Technology with emphasis on Industrial Biotechnology, Bioproducts, Biomaterials and Medical Biotechnology with emphasis on Biomaterials. His main research activities are in the area of Biofilms particularly with application in the Industrial (mainly Food industry), Medical (mainly in biomedical devices and implants) and Environmental (mainly marine biofilms) sectors.
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Identification

Personal identification

Full name
Filipe José Menezes Mergulhão

Citation names

  • Mergulhão, Filipe

Author identifiers

Ciência ID
E310-ABDE-8A70
ORCID iD
0000-0001-5233-1037
Scopus Author Id
6506782617

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Microbiology
  • Medical and Health Sciences - Medical Biotechnology - Biomaterials
  • Engineering and Technology - Industrial Biotechnology - Bioproducts Biomaterials

Languages

Language Speaking Reading Writing Listening Peer-review
English Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
2002
Concluded
 Engenharia Química (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
"Design of bacterial vector systems for the secretion of recombinant proteins" (THESIS/DISSERTATION)
 Approved (maximum classification)
1998
Concluded
 Engenharia Química (Licenciatura)
Universidade de Lisboa Instituto Superior Técnico, Portugal
 16/20
Affiliation

Science

Category
Host institution 		Employer
2007 - Current Researcher (Research) Universidade do Porto Laboratorio de Engenharia de Processos Ambiente Biotecnologia e Energia, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2022/02/03 - Current Associate Professor (University Teacher) Universidade do Porto Faculdade de Engenharia, Portugal
2005 - 2022 Assistant Professor (University Teacher) Universidade do Porto Faculdade de Engenharia, Portugal
2016 - 2019 Assistant Professor (University Teacher) Universidade do Porto, Portugal
2013 - 2016 Assistant Professor (University Teacher) Universidade do Porto Faculdade de Engenharia, Portugal
2012/02/15 - 2012/07/30 Invited Assistant Professor (University Teacher) Stanford University Department of Microbiology and Immunology, United States
2002 - 2003 Assistant Professor (University Teacher) Universidade Lusófona de Humanidades e Tecnologias, Portugal
1998 - 1999 Assistant (University Teacher) Universidade de Lisboa Instituto Superior Técnico, Portugal

Others

Category
Host institution 		Employer
2002 - 2005 Post-doctoral fellow Universidade de Lisboa Instituto Superior Técnico, Portugal
2003 - 2003 Post-doctoral fellow Massachusetts Institute of Technology Department of Chemistry, United States
2003 - 2003 Post-doctoral fellow University of Cambridge, United Kingdom
1998 - 2002 PhD fellow Universidade de Lisboa Instituto Superior Técnico, Portugal
2000 - 2000 PhD fellow Kungliga Tekniska Högskolan, Sweden
1997 - 1997 Erasmus fellow University of St Andrews School of Biology, United Kingdom
Projects

Grant

Designation Funders
2010/06 - 2013/11 Bioresist - The influence of biofilm phenotype on its resilience and resistance
Provided by PTCRIS: 105085
PTDC/EBB-EBI/105085/2008
Researcher
Universidade do Porto Laboratorio de Engenharia de Processos Ambiente Biotecnologia e Energia, Portugal

Universidade do Porto Faculdade de Engenharia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/05 - 2013/11 SYNBIOBACTHER - Synthetic biology approaches to engineer "therapeutic" bacteria
Provided by PTCRIS: 102863
PTDC/EBB-BIO/102863/2008
Researcher
Instituto de Biotecnologia e Bioengenharia, Portugal

Universidade do Minho, Portugal

Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade do Porto Faculdade de Engenharia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/05 - 2013/10 Filmstart - Initial conditions controlling the onset of biofilms
Provided by PTCRIS: 104940
PTDC/EBB-BIO/104940/2008
Principal investigator
Universidade do Porto Laboratorio de Engenharia de Processos Ambiente Biotecnologia e Energia, Portugal

Universidade do Porto Faculdade de Engenharia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2007/07 - 2010/09 The interaction between recombinant protein secretion and biofilm formation and stability
Provided by PTCRIS: 69092
PTDC/BIO/69092/2006
Principal investigator
Universidade do Porto Laboratorio de Engenharia de Processos Ambiente Biotecnologia e Energia, Portugal

Universidade do Porto Faculdade de Engenharia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2018/08/01 - Current DelNam - Strengthening the Research Area of Delivery of Nucleic acid mimics (NAMS) into bacteria to fight the antibiotic crisis
810685
810685
Researcher
Universidade do Porto Laboratorio de Engenharia de Processos Ambiente Biotecnologia e Energia, Portugal
 N/A
Ongoing
2017/01/01 - Current PRINT-AID - Multidisciplinary european training network for development of personalized anti-infective medical devices combining printing technologies and antimicrobial functionality
722467
Researcher
Universidade do Porto Laboratorio de Engenharia de Processos Ambiente Biotecnologia e Energia, Portugal
Ongoing
2023/03/01 - 2026/02/28 Controlling bacteria and allergen contamination in the food industry using biomimetic surfaces
2022.05314.PTDC
Universidade do Porto Faculdade de Engenharia, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2023/03/01 - 2026/02/28 Nanoengineered systems tailored with natural phytochemicals for biofouling mitigation on industrial surfaces
2022.06149.PTDC
10.54499/2022.06149.PTDC
FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade do Porto Faculdade de Engenharia, Portugal

Universidade do Porto Faculdade de Ciências, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2023/03/12 - 2024/09/11 Análogo do sangue multidimensional para testes in vitro
2022.08598.PTDC
10.54499/2022.08598.PTDC
Universidade do Porto Faculdade de Engenharia, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2021/03/01 - 2024/02/29 NanoCAT - Using modified carbon nanotubes to prevent biofilm formation in urinary catheters and stents
PTDC/CTM-COM/4844/2020
10.54499/PTDC/CTM-COM/4844/2020
Universidade do Porto Laboratorio de Engenharia de Processos Ambiente Biotecnologia e Energia, Portugal

Universidade do Porto Faculdade de Engenharia, Portugal

Universidade do Porto Laboratório de Processos de Separação e Reacção Laboratório de Catálise e Materiais, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2020/01/01 - 2023/12/31 Laboratory for Process Engineering, Environment, Biotechnology and Energy
UIDB/00511/2020
10.54499/UIDB/00511/2020
10.54499/UIDP/00511/2020
UIDP/00511/2020
Universidade do Porto Laboratorio de Engenharia de Processos Ambiente Biotecnologia e Energia, Portugal

Universidade do Porto Faculdade de Engenharia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2020/03 - 2023/12 SurfSafe - Surface modification to increase microbial SAFEty in the food industry
952471
Principal investigator
Universidade do Porto Laboratorio de Engenharia de Processos Ambiente Biotecnologia e Energia, Portugal
Ongoing
2018/10/01 - 2022/05/31 FIlmprot - The use of Escherichia coli biofilms for the production of recombinant proteins and other added-value compounds
POCI-01-0145-FEDER-029589
PTDC/BII-BIO/29589/2017
Principal investigator
Universidade do Porto Laboratorio de Engenharia de Processos Ambiente Biotecnologia e Energia, Portugal

Universidade do Porto, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2015/10/01 - 2020/06/30 CVMar+i - Inovação industrial através de colaborações específicas entre empresas e centros de investigação no contexto de valorização biotecnológica marinha
0302_CVMAR_I_1_P
Researcher
Universidade do Porto Laboratorio de Engenharia de Processos Ambiente Biotecnologia e Energia, Portugal
Ongoing
2019/01/01 - 2019/12/31 Projeto Estratégico do LEPABE - Laboratório de Engenharia de Processos, Ambiente, Biotecnologia e Energia - Coordinator of the Biotechnology group
UID/EQU/00511/2019
UID/EQU/00511/2019
Researcher
Universidade do Porto Laboratorio de Engenharia de Processos Ambiente Biotecnologia e Energia, Portugal
 N/A
Concluded
2016/04/01 - 2019/09/30 LEPABE-2-ECO-INNOVATION - Coordinator of the Biotechnology group
NORTE-01-0145-FEDER-000005
Researcher
Universidade do Porto Laboratorio de Engenharia de Processos Ambiente Biotecnologia e Energia, Portugal
Concluded
2015/10/02 - 2019/01/31 Pomacea - Tecnologias económicas para controlo de (bio)fouling em membranas através da otimização de métodos de pré-tratamentos de limpeza
INN-INDIGO/0001/2014
Researcher
Concluded
2015/10/02 - 2019/01/31 Affordable technology for mitigation of membrane biofouling through optimization of pre-treatment and cleaning methods
Inn-INDIGO/0001/2014
Universidade do Porto Laboratorio de Engenharia de Processos Ambiente Biotecnologia e Energia, Portugal

Universidade do Porto Faculdade de Engenharia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2015/01/01 - 2018/12/31 Projeto Estratégico - UID/EQU/00511/2013 - Coordinator of the Biotechnology group
UID/EQU/00511/2013 - POCI-01-0145-FEDER-006939
Researcher
Universidade do Porto Laboratorio de Engenharia de Processos Ambiente Biotecnologia e Energia, Portugal
Concluded
2014/01/01 - 2015/12/31 Programa Incentivo/EQB/UI0511/2014 - Coordinator of the Biotechnology group
Incentivo/EQB/UI0511/2014
Researcher
Universidade do Porto Laboratorio de Engenharia de Processos Ambiente Biotecnologia e Energia, Portugal
Concluded
2013/07/01 - 2015/10/31 Novomar - Consolidação do Centro Multipolar de Valorização de Recursos Marinhos visando novos usos do mar
0687_NOVOMAR_1_P
Researcher
Universidade do Porto Laboratorio de Engenharia de Processos Ambiente Biotecnologia e Energia, Portugal
Concluded
2013/07 - 2015/08 Phytodisinfectants - Disinfection of planktonic bacteria and biofilms in hospital settings with phytochemical products
Provided by PTCRIS: 125925
PTDC/DTP-SAP/1078/2012
Researcher
Universidade do Porto Laboratorio de Engenharia de Processos Ambiente Biotecnologia e Energia, Portugal

Universidade do Porto Faculdade de Engenharia, Portugal

Universidade de Trás-os-Montes e Alto Douro, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2014/01/01 - 2015/06/30 (Bio) Chemical Engineering: Multi-Scale Approaches for Sustainable Environment and Health - Coordinator of the Biotechnology group
NORTE-07-0124-FEDER-000025
Researcher
Universidade do Porto Laboratorio de Engenharia de Processos Ambiente Biotecnologia e Energia, Portugal
Concluded
2014/01/01 - 2015/06/30 Chemical Engineering: Process Optimization and Energy Conversion - Coordinator of the Biotechnology Group
NORTE-07-0124-FEDER-000026
Researcher
Universidade do Porto Laboratorio de Engenharia de Processos Ambiente Biotecnologia e Energia, Portugal
Concluded
2013/01/01 - 2014/12/31 PROJECTO ESTRATÉGICO - UI 511 - 2013-2014 - Coordinator of the Biotechnology Group
PEst-C/EQB/UI0511/2013
Researcher
Universidade do Porto Laboratorio de Engenharia de Processos Ambiente Biotecnologia e Energia, Portugal
Concluded
2012/01/01 - 2014/12/31 Susclean - Sustainable Cleaning and Disinfection in Fresh-Cut Food Industries
287514
Researcher
Universidade do Porto Laboratorio de Engenharia de Processos Ambiente Biotecnologia e Energia, Portugal
Concluded
2010/05/01 - 2013/10/30 Fouling and cleaning of micro channels
PTDC/EQU-FTT/105535/2008
Provided by PTCRIS: 105535
Researcher
Universidade do Porto Centro de Estudos de Fenómenos de Transporte, Portugal

Universidade do Porto Faculdade de Engenharia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2012/12/31 PROJECTO ESTRATÉGICO - UI 511 - 2011-2012
FCOMP-01-0124-FEDER-022677
Researcher
Universidade do Porto Laboratorio de Engenharia de Processos Ambiente Biotecnologia e Energia, Portugal
Concluded
2009/04/01 - 2012/09/30 Bridging Systems and Synthetic Biology for the development of Improved Microbial Cell Factories
MIT-Pt/BS-BB/0082/2008
Provided by PTCRIS: 84035
Researcher
Universidade do Minho, Portugal

Universidade do Minho Centro de Engenharia Biológica, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal

Universidade do Porto Faculdade de Engenharia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2002/10/01 - 2005/08/31 PHYSIOLOGICAL ENGINEERING OF ESCHERICHIA COLI: APPLICATIONS IN GENE THERAPY AND RECOMBINANT PROTEIN PRODUCTION
SFRH/BPD/9428/2002
University of Cambridge, United Kingdom
 Fundação para a Ciência e a Tecnologia
Concluded
1998/06/01 - 2002/05/31 DESIGN DE SISTEMAS DE EXPRESSÃO GENÉTICA BACTERIANOS PARA A OPTIMIZAÇÃO DE PROCESSOS DE PURIFICAÇÃO DE PROTEÍNAS HUMANAS RECOMBINADAS
PRAXIS XXI/BD/15841/98
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book
  1. Romeu, M.J.; Alves, P.; Morais, J.; Ramos, V.; Vasconcelos, V.; Mergulhão, F.J.. Biofilm formation by a cyanobacterium strain belonging to a distinct leptolyngbya phylotype: Surface effect. 2016.
  2. Mergulhão, Filipe. Biofilms in Bioengineering. Nova Science Publishers. 2013.
  3. Teodósio, J.S.; Simões, M.; Melo, L.F.; Mergulhão, F.J.. The influence of arecombinant plasmid on the formation of Escherichia coli biofilms. 2011.
  4. Mergulhão, F.J.; Monteiro, G.A.. Periplasmic targeting of recombinant proteins in Escherichia coli. 2007.
    10.1007/978-1-59745-466-7_4
Book chapter
  1. Azevedo, A.; Carvalho, F.M.; Gomes, L.C.; Mergulhão, F.J.M.. "Use of bacterial biofilms to produce high added-value compounds". 665-681. 2022.
    10.1016/b978-0-323-99977-9.00015-6
  2. Abou-Hassan, A.; Barros, A.A.; Buchholz, N.; Carug, D.; Clavica, F.; Mergulhao, F.; Zheng, S.. "Preventing Biofilm Formation and Encrustation on Urinary Implants: (Bio)molecular and Physical Research Approaches". 437-447. 2022.
  3. Romeu, M.J.; Gomes, L.C.; Teixeira-Santos, R.; Mergulhão, F.J.. "Cyanobacteria in marine biofilms: Hydrodynamic and surface effects". 297-332. 2022.
  4. Gomes, L.C.; Teixeira-Santos, R.; Romeu, M.J.; Mergulhão, F.J.. "Bacterial Adhesion and Biofilm Formation: Hydrodynamics Effects". 225-243. 2022.
  5. Teixeira-Santos, R.; Gomes, L.C.; Mergulhão, F.J.. "DEVELOPMENT OF MARINE BIOFILMS BY COCCOID CYANOBACTERIA". 75-105. 2021.
  6. Moreira, J.M.R.; Araújo, J.D.P.; Simões, M.; Melo, L.F.; Mergulhão, F.J.. "Influence of surface conditioning with culture medium components on Escherichia coli biofilm formation". 2233-2248. 2021.
  7. Borges, A.; Meireles, A.; Mergulhão, F.; Melo, L.; Simões, M.. "Biofilm control with enzymes". 249-271. 2020.
    10.1016/b978-0-12-819497-3.00011-8
  8. Gomes, M.; Gomes, L.C.; Teixeira-Santos, R.; Mergulhão, F.J.. "PDMS IN URINARY TRACT DEVICES: APPLICATIONS, PROBLEMS AND POTENTIAL SOLUTIONS". 95-144. 2020.
  9. Teixeira-Santos, R.; Gomes, M.; Mergulhão, F.J.. "Carbon Nanotube-Based Antimicrobial and Antifouling Surfaces". 65-93. 2020.
    10.1007/978-981-15-4630-3_4
  10. Gomes, LucianaCalheiros; Silva, LauraNunes; Simões, Manuel; de Melo, LuísFerreira; Mergulhão, FilipeJosé. "Exploring the Antibiotic Effects in Bacterial Biofilms by Epifluorescence and Scanning Electron Microscopy". edited by Polychroniadis, E. K.; Oral, Ahmet Yavuz; Ozer, Mehmet, 241-248. Springer International Publishing, 2015.
    10.1007/978-3-319-16919-4_31
Conference abstract
  1. Mergulhao, FJM; Monteiro, GA. "The secretion efficiency of the Escherichia coli Sec pathway is dependent on the growth phase but not on protein size". 2005.
Journal article
  1. Marisa Gomes; Rita Teixeira-Santos; Luciana C. Gomes; Francisca Sousa-Cardoso; Fábio M. Carvalho; Andreia R. Tomé; Olívia S. G. P. Soares; Kathryn A. Whitehead; Filipe J. Mergulhão. "Antibiofilm Effect of Nitric Acid-Functionalized Carbon Nanotube-Based Surfaces against E. coli and S. aureus". Antibiotics (2023): https://doi.org/10.3390/antibiotics12111620.
    10.3390/antibiotics12111620
  2. Rita Teixeira-Santos; Samuel Belo; Rita Vieira; Filipe J. M. Mergulhão; Luciana C. Gomes. "Graphene-Based Composites for Biomedical Applications: Surface Modification for Enhanced Antimicrobial Activity and Biocompatibility". Biomolecules (2023): https://doi.org/10.3390/biom13111571.
    10.3390/biom13111571
  3. Rita Teixeira-Santos; Luciana C. Gomes; Rita Vieira; Francisca Sousa-Cardoso; Olívia S. G. P. Soares; Filipe J. Mergulhão. "Exploring Nitrogen-Functionalized Graphene Composites for Urinary Catheter Applications". Nanomaterials (2023): https://doi.org/10.3390/nano13182604.
    10.3390/nano13182604
  4. Maria João Romeu; João Morais; Vítor Vasconcelos; Filipe Mergulhão. "Effect of Hydrogen Peroxide on Cyanobacterial Biofilms". Antibiotics (2023): https://doi.org/10.3390/antibiotics12091450.
    10.3390/antibiotics12091450
  5. Samuel Belo; Francisca Sousa-Cardoso; Rita Teixeira-Santos; Luciana C. Gomes; Rita Vieira; Jelmer Sjollema; Olívia S. G. P. Soares; Filipe J. Mergulhão. "Production and Characterization of Graphene Oxide Surfaces against Uropathogens". Coatings (2023): https://doi.org/10.3390/coatings13081324.
    10.3390/coatings13081324
  6. Maria João Romeu; Filipe Mergulhão. "Development of Antifouling Strategies for Marine Applications". Microorganisms (2023): https://doi.org/10.3390/microorganisms11061568.
    10.3390/microorganisms11061568
  7. Andreia R. Tomé; Fábio M. Carvalho; Rita Teixeira-Santos; Mette Burmølle; Filipe J. M. Mergulhão; Luciana C. Gomes. "Use of Probiotics to Control Biofilm Formation in Food Industries". Antibiotics (2023): https://doi.org/10.3390/antibiotics12040754.
    10.3390/antibiotics12040754
  8. Francisca Sousa-Cardoso; Rita Teixeira-Santos; Ana Francisca Campos; Marta Lima; Luciana C. Gomes; Olívia S. G. P. Soares; Filipe J. Mergulhão. "Graphene-Based Coating to Mitigate Biofilm Development in Marine Environments". Nanomaterials (2023): https://doi.org/10.3390/nano13030381.
    10.3390/nano13030381
  9. Emanuel M. Fernandes; Flávia C. M. Lobo; Sara I. Faria; Luciana C. Gomes; Tiago H. Silva; Filipe J. M. Mergulhão; Rui L. Reis. "Development of Cork Biocomposites Enriched with Chitosan Targeting Antibacterial and Antifouling Properties". Molecules (2023): https://doi.org/10.3390/molecules28030990.
    10.3390/molecules28030990
  10. Ana Rita Neves; Joana Freitas-Silva; Fernando Durães; Elisabete R. Silva; Inês C. Rodrigues; Filipe Mergulhão; Marisa Gomes; et al. "Insights into the antimicrobial properties of a cationic steroid and antibiofilm performance in PDMS-based coatings to potentially treat urinary infections". Journal of Materials Chemistry B 11 36 (2023): 8697-8716. http://dx.doi.org/10.1039/d3tb01185b.
    10.1039/d3tb01185b
  11. Romeu, MJ; Morais, J; Gomes, LC; Silva, R; Vasconcelos, V; Mergulhao, FJM. "Characterization and biofouling potential analysis of two cyanobacterial strains isolated from Cape Verde and Morocco". FEMS MICROBIOLOGY ECOLOGY (2023):
    10.1093/femsec/fiad004
  12. Maria J. Romeu; Luciana C. Gomes; Francisca Sousa-Cardoso; João Morais; Vítor Vasconcelos; Kathryn A. Whitehead; Manuel F. R. Pereira; Olívia S. G. P. Soares; Filipe J. Mergulhão. "How do Graphene Composite Surfaces Affect the Development and Structure of Marine Cyanobacterial Biofilms?". Coatings (2022): https://doi.org/10.3390/coatings12111775.
    10.3390/coatings12111775
  13. M López-Álvarez; L González-Rodríguez; F Gontad; R Teixeira-Santos; M Doiro; L Álvarez-Gómez; F J M Mergulhão; P González; J Serra. "Dual pulsed laser deposition of Ag nanoparticles on calcium phosphate coatings for biomedical applications". Biomedical Physics & Engineering Express (2022): https://doi.org/10.1088/2057-1976/ac9846.
    10.1088/2057-1976/ac9846
  14. Filipe Mergulhão; Marisa Gomes; Luciana Gomes; Rita Teixeira-Santos; Manuel F.R. Pereira; Olívia S.G.P. Soares; Filipe J. Mergulhão. "Carbon nanotube-based surfaces: Effect on the inhibition of single- and dual-species biofilms of Escherichia coli and Enterococcus faecalis". Results in Surfaces and Interfaces 9 (2022): 100090-100090. http://dx.doi.org/10.1016/j.rsurfi.2022.100090.
    10.1016/j.rsurfi.2022.100090
  15. Marta Lima; Luciana Gomes; Rita Santos; Maria João Leal Romeu; Jesus Valcarcel; José Antonio Vázquez Álvarez; Miguel Ângelo Cerqueira; et al. "Assessment of the Antibiofilm Performance of Chitosan-Based Surfaces in Marine Environments". International Journal of Molecular Sciences (2022): https://www.mdpi.com/1422-0067/23/23/14647.
    10.3390/ijms232314647
  16. Maria J. Romeu; Marta Lima; Luciana C. Gomes; Ed. D. de Jong; João Morais; Vítor Vasconcelos; Manuel F. R. Pereira; et al. "The Use of 3D Optical Coherence Tomography to Analyze the Architecture of Cyanobacterial Biofilms Formed on a Carbon Nanotube Composite". Polymers (2022): https://doi.org/10.3390/polym14204410.
    10.3390/polym14204410
  17. Maria J. Romeu; Dany Domínguez-Pérez; Daniela Almeida; João Morais; Mário J. Araújo; Hugo Osório; Alexandre Campos; Vítor Vasconcelos; Filipe J. Mergulhão. "Hydrodynamic conditions affect the proteomic profile of marine biofilms formed by filamentous cyanobacterium". npj Biofilms and Microbiomes (2022): https://doi.org/10.1038/s41522-022-00340-w.
    10.1038/s41522-022-00340-w
  18. Francisca Sousa-Cardoso; Rita Teixeira-Santos; Filipe J. M. Mergulhão. "Antifouling Performance of Carbon-Based Coatings for Marine Applications: A Systematic Review". Antibiotics (2022): https://doi.org/10.3390/antibiotics11081102.
    10.3390/antibiotics11081102
  19. Ana Rita Neves; Luciana Gomes; Sara I. Faria; João Sousa; Raquel Ruivo; Inês Páscoa; Madalena M. M. Pinto; et al. "Antifouling Marine Coatings with a Potentially Safer and Sustainable Synthetic Polyphenolic Derivative". Marine Drugs (2022): https://www.mdpi.com/1660-3397/20/8/507.
    10.3390/md20080507
  20. Fábio Carvalho; Ana Azevedo; Marta Ferreira; Filipe Mergulhão; Luciana Gomes. "Advances on Bacterial and Fungal Biofilms for the Production of Added-Value Compounds". Biology (2022): https://doi.org/10.3390/biology11081126.
    10.3390/biology11081126
  21. Alexandra Soares; Luciana C. Gomes; Gabriel A. Monteiro; Filipe J. Mergulhão. "Hydrodynamic Effects on Biofilm Development and Recombinant Protein Expression". Microorganisms (2022): https://doi.org/10.3390/microorganisms10050931.
    10.3390/microorganisms10050931
  22. Luciana C. Gomes; Carla Ferreira; Filipe J. Mergulhão. "Implementation of a Practical Teaching Course on Protein Engineering". Biology 11 3 (2022): 387-387. https://doi.org/10.3390/biology11030387.
    10.3390/biology11030387
  23. "Oriented immobilization of Pep19-2.5 on antifouling brushes suppresses the development of Staphylococcus aureus biofilms". Progress in Organic Coatings 163 (2022): 106609-106609. http://dx.doi.org/10.1016/j.porgcoat.2021.106609.
    10.1016/j.porgcoat.2021.106609
  24. Isabel M. Oliveira; Marisa Gomes; Luciana C. Gomes; Manuel F. R. Pereira; Olívia S. G. P. Soares; Filipe J. Mergulhão. "Performance of Graphene/Polydimethylsiloxane Surfaces against S. aureus and P. aeruginosa Single- and Dual-Species Biofilms". Nanomaterials 12 3 (2022): 355-355. https://doi.org/10.3390/nano12030355.
    10.3390/nano12030355
  25. Teixeira-Santos, R; Gomes, LC; Mergulhão, FJ. "Recent advances in antimicrobial surfaces for urinary catheters". Current Opinion in Biomedical Engineering (2022):
    10.1016/j.cobme.2022.100394
  26. Gomes, LC; Saubade, F; Amin, M; Spall, J; Liauw, CM; Mergulhao, F; Whitehead, KA. "A comparison of vegetable leaves and replicated biomimetic surfaces on the binding of Escherichia coli and Listeria monocytogenes". FOOD AND BIOPRODUCTS PROCESSING (2022):
    10.1016/j.fbp.2022.11.003
  27. "Using Lactobacilli to Fight Escherichia coli and Staphylococcus aureus Biofilms on Urinary Tract Devices". Antibiotics 10 12 (2021): 1525-1525. http://dx.doi.org/10.3390/antibiotics10121525.
    10.3390/antibiotics10121525
  28. "Antimicrobial coatings based on chitosan to prevent implant-associated infections: A systematic review". iScience 24 12 (2021): 103480-103480. http://dx.doi.org/10.1016/j.isci.2021.103480.
    10.1016/j.isci.2021.103480
  29. "Future Directions for Ureteral Stent Technology: From Bench to the Market". Advanced Therapeutics (2021): 2100158-2100158. http://dx.doi.org/10.1002/adtp.202100158.
    10.1002/adtp.202100158
  30. M.J. Romeu; D. Domínguez-Pérez; D. Almeida; J. Morais; M.J. Araújo; H. Osório; A. Campos; V. Vasconcelos; F.J. Mergulhão. "Quantitative proteomic analysis of marine biofilms formed by filamentous cyanobacterium". Environmental Research 201 (2021): 111566-111566. https://doi.org/10.1016/j.envres.2021.111566.
    10.1016/j.envres.2021.111566
  31. Luciana C. Gomes; Filipe J. M. Mergulhão. "A Selection of Platforms to Evaluate Surface Adhesion and Biofilm Formation in Controlled Hydrodynamic Conditions". Microorganisms 9 9 (2021): 1993-1993. https://doi.org/10.3390/microorganisms9091993.
    10.3390/microorganisms9091993
  32. Alexandra Soares; Luciana C. Gomes; Gabriel A. Monteiro; Filipe J. Mergulhão. "The Influence of Nutrient Medium Composition on Escherichia coli Biofilm Development and Heterologous Protein Expression". Applied Sciences (2021): https://doi.org/10.3390/app11188667.
    10.3390/app11188667
  33. Fábio M. Carvalho; Rita Teixeira-Santos; Filipe J. M. Mergulhão; Luciana C. Gomes. "Effect of Lactobacillus plantarum Biofilms on the Adhesion of Escherichia coli to Urinary Tract Devices". Antibiotics 10 8 (2021): 966-966. https://doi.org/10.3390/antibiotics10080966.
    10.3390/antibiotics10080966
  34. Mergulhão, Filipe. "Development of Chitosan-Based Surfaces to Prevent Single- and Dual-Species Biofilms of Staphylococcus aureus and Pseudomonas aeruginosa". Molecules 26 14 (2021): 4378-4378. http://dx.doi.org/10.3390/molecules26144378.
    10.3390/molecules26144378
  35. "Principal Component Analysis to Determine the Surface Properties That Influence the Self-Cleaning Action of Hydrophobic Plant Leaves". Langmuir 37 27 (2021): 8177-8189. http://dx.doi.org/10.1021/acs.langmuir.1c00853.
    10.1021/acs.langmuir.1c00853
  36. Luciana C. Gomes; Sara I. Faria; Jesus Valcarcel; José A. Vázquez; Miguel A. Cerqueira; Lorenzo Pastrana; Ana I. Bourbon; Filipe J. Mergulhão. "The Effect of Molecular Weight on the Antimicrobial Activity of Chitosan from Loligo opalescens for Food Packaging Applications". Marine Drugs 19 7 (2021): 384-384. https://doi.org/10.3390/md19070384.
    10.3390/md19070384
  37. "Celebrating the centenary in polymer science: Drawing inspiration from nature to develop anti-fouling coatings. The development of biomimetic polymer surfaces and their effect on bacterial fouling". Pure and Applied Chemistry 0 0 (2021): http://dx.doi.org/10.1515/pac-2021-0108.
    10.1515/pac-2021-0108
  38. "Assessment of the environmental compatibility and antifouling performance of an innovative biocidal and foul-release multifunctional marine coating". Environmental Research 198 (2021): 111219-111219. http://dx.doi.org/10.1016/j.envres.2021.111219.
    10.1016/j.envres.2021.111219
  39. Ali Abou-Hassan; Alexandre Barros; Noor Buchholz; Dario Carugo; Francesco Clavica; Petra de Graaf; Julia de La Cruz; et al. "Potential strategies to prevent encrustations on urinary stents and catheters – thinking outside the box: a European network of multidisciplinary research to improve urinary stents (ENIUS) initiative". Expert Review of Medical Devices (2021): https://doi.org/10.1080/17434440.2021.1939010.
    10.1080/17434440.2021.1939010
  40. Sara I. Faria; Rita Teixeira-Santos; Maria J. Romeu; João Morais; Ed de Jong; Jelmer Sjollema; Vítor Vasconcelos; Filipe J. Mergulhão. "Unveiling the Antifouling Performance of Different Marine Surfaces and Their Effect on the Development and Structure of Cyanobacterial Biofilms". Microorganisms (2021): https://doi.org/10.3390/microorganisms9051102.
    10.3390/microorganisms9051102
  41. Marisa Gomes; Luciana C. Gomes; Rita Teixeira-Santos; Manuel F. R. Pereira; Olívia S. G. P. Soares; Filipe J. Mergulhão. "Optimizing CNT Loading in Antimicrobial Composites for Urinary Tract Application". Applied Sciences 11 9 (2021): 4038-4038. https://doi.org/10.3390/app11094038.
    10.3390/app11094038
  42. "The association between initial adhesion and cyanobacterial biofilm development". FEMS Microbiology Ecology 97 5 (2021): http://dx.doi.org/10.1093/femsec/fiab052.
    10.1093/femsec/fiab052
  43. Olga Ferreira; Patrícia Rijo; João Gomes; Ricardo Santos; Sílvia Monteiro; Rita Guedes; Maria Luísa Serralheiro; et al. "Antimicrobial Ceramic Filters for Water Bio-Decontamination". Coatings 11 3 (2021): 323-323. https://doi.org/10.3390/coatings11030323.
    10.3390/coatings11030323
  44. Sara I. Faria; Luciana C. Gomes; Rita Teixeira-Santos; João Morais; Vítor Vasconcelos; Filipe J. M. Mergulhão. "Developing New Marine Antifouling Surfaces: Learning from Single-Strain Laboratory Tests". Coatings 11 1 (2021): 90-90. https://doi.org/10.3390/coatings11010090.
    10.3390/coatings11010090
  45. Mergulhão, Filipe. "Targeting biofilms in medical devices using probiotic cells: a systematic review". AIMS Materials Science 8 4 (2021): 501-523. http://dx.doi.org/10.3934/matersci.2021031.
    10.3934/matersci.2021031
  46. "Surface activation of medical grade polyurethane for the covalent immobilization of an anti-adhesive biopolymeric coating". Journal of Materials Chemistry B 9 17 (2021): 3705-3715. http://dx.doi.org/10.1039/d1tb00278c.
    10.1039/d1tb00278c
  47. Mergulhão, Filipe. "Antimicrobial and anti-adhesive properties of carbon nanotube-based surfaces for medical applications: a systematic review.". iScience (2020): https://europepmc.org/articles/PMC7809508.
    10.1016/j.isci.2020.102001
  48. Fábio M. Carvalho; Rita Teixeira-Santos; Filipe J. M. Mergulhão; Luciana C. Gomes. "The Use of Probiotics to Fight Biofilms in Medical Devices: A Systematic Review and Meta-Analysis". Microorganisms (2020): https://doi.org/10.3390/microorganisms9010027.
    10.3390/microorganisms9010027
  49. Mergulhão, Filipe. "Cell adhesion in microchannel multiple constrictions - Evidence of mass transport limitations.". Colloids and surfaces. B, Biointerfaces (2020): https://doi.org/10.1016/j.colsurfb.2020.111490.
    10.1016/j.colsurfb.2020.111490
  50. Andreia S. Azevedo; Gislaine P. Gerola; João Baptista; Carina Almeida; Joana Peres; Filipe J. Mergulhão; Nuno F. Azevedo. "Increased Intraspecies Diversity in Escherichia coli Biofilms Promotes Cellular Growth at the Expense of Matrix Production". Antibiotics (2020): https://doi.org/10.3390/antibiotics9110818.
    10.3390/antibiotics9110818
  51. Mergulhão, Filipe. "Combining chemistry and topography to fight biofilm formation: Fabrication of micropatterned surfaces with a peptide-based coating.". Colloids and surfaces. B, Biointerfaces (2020): https://doi.org/10.1016/j.colsurfb.2020.111365.
    10.1016/j.colsurfb.2020.111365
  52. Sara I. Faria; Rita Teixeira-Santos; Luciana C. Gomes; Elisabete R. Silva; João Morais; Vítor Vasconcelos; Filipe J. M. Mergulhão. "Experimental Assessment of the Performance of Two Marine Coatings to Curb Biofilm Formation of Microfoulers". Coatings (2020): https://doi.org/10.3390/coatings10090893.
    10.3390/coatings10090893
  53. Maria João Leal Romeu; Dany Domínguez-Pérez; Daniela Almeida; João Morais; Alexandre Campos; Vítor Vasconcelos; Filipe J. M. Mergulhão. "Characterization of planktonic and biofilm cells from two filamentous cyanobacteria using a shotgun proteomic approach". Biofouling (2020): https://doi.org/10.1080/08927014.2020.1795141.
    10.1080/08927014.2020.1795141
  54. Márcia R. Vagos; Marisa Gomes; Joana M. R. Moreira; Olívia S. G. P. Soares; Manuel F. R. Pereira; Filipe J. Mergulhão. "Carbon Nanotube/Poly(dimethylsiloxane) Composite Materials to Reduce Bacterial Adhesion". Antibiotics 9 8 (2020): 434-434. https://doi.org/10.3390/antibiotics9080434.
    10.3390/antibiotics9080434
  55. Patrícia Alves; Joana Maria Moreira; João Mário Miranda; Filipe José Mergulhão. "Analysing the Initial Bacterial Adhesion to Evaluate the Performance of Antifouling Surfaces". Antibiotics 9 7 (2020): 421-421. https://doi.org/10.3390/antibiotics9070421.
    10.3390/antibiotics9070421
  56. P Alves; LC Gomes; M Vorobii; C Rodriguez-Emmenegger; FJ Mergulhão. "The potential advantages of using a poly(HPMA) brush in urinary catheters: effects on biofilm cells and architecture". Colloids and Surfaces B: Biointerfaces (2020): https://doi.org/10.1016/j.colsurfb.2020.110976.
    10.1016/j.colsurfb.2020.110976
  57. Patrícia Alves; Luciana Calheiros Gomes; Cesar Rodríguez-Emmenegger; Filipe José Mergulhão. "Efficacy of A Poly(MeOEGMA) Brush on the Prevention of Escherichia coli Biofilm Formation and Susceptibility". Antibiotics 9 5 (2020): 216-216. https://doi.org/10.3390/antibiotics9050216.
    10.3390/antibiotics9050216
  58. Sara I. Faria; Rita Teixeira-Santos; Maria J. Romeu; João Morais; Vitor Vasconcelos; Filipe J. Mergulhão. "The Relative Importance of Shear Forces and Surface Hydrophobicity on Biofilm Formation by Coccoid Cyanobacteria". Polymers 12 3 (2020): 653-653. https://doi.org/10.3390/polym12030653.
    10.3390/polym12030653
  59. Mergulhão, Filipe. "Magnetron co-sputtered TiO2/SiO2/Ag nanocomposite thin coatings inhibiting bacterial adhesion and biofilm formation". Surface and Coatings Technology (2020): http://dx.doi.org/10.1016/j.surfcoat.2019.125322.
    10.1016/j.surfcoat.2019.125322
  60. Luciana Gomes; Gabriel Monteiro; Filipe Mergulhão. "The Impact of IPTG Induction on Plasmid Stability and Heterologous Protein Expression by Escherichia coli Biofilms". International Journal of Molecular Sciences (2020): https://doi.org/10.3390/ijms21020576.
    10.3390/ijms21020576
  61. Maria J. Romeu; Patrícia Alves; João Morais; João M. Miranda; Ed.D. Jong; Jelmer Sjollema; Vítor Ramos; Vitor Vasconcelos; Filipe J. M. Mergulhão. "Biofilm formation behaviour of marine filamentous cyanobacterial strains in controlled hydrodynamic conditions". Environmental Microbiology 21 11 (2019): 4411-4424. https://doi.org/10.1111/1462-2920.14807.
    10.1111/1462-2920.14807
  62. J Ponmozhi; J. M. R. Moreira; Filipe Mergulhão; J. B. L. M. Campos; Joao Miranda. "Fabrication and Hydrodynamic Characterization of a Microfluidic Device for Cell Adhesion Tests in Polymeric Surfaces". Micromachines (2019): https://www.mdpi.com/2072-666X/10/5/303.
    10.3390/mi10050303
  63. Mergulhão, Filipe. "Evaluating Efficacy of Antimicrobial and Antifouling Materials for Urinary Tract Medical Devices: Challenges and Recommendations". Macromolecular Bioscience (2019): http://dx.doi.org/10.1002/mabi.201800384.
    10.1002/mabi.201800384
  64. Márcia R. Vagos; Joana M.R. Moreira; Olivia S.G.P. Soares; Manuel F.R. Pereira; Filipe J. Mergulhão. "Incorporation of carbon nanotubes in polydimethylsiloxane to control Escherichia coli adhesion". Polymer Composites (2019): https://doi.org/10.1002/pc.25125.
    10.1002/pc.25125
  65. Mergulhão, Filipe. "Recombinant protein expression in biofilms". AIMS Microbiology (2019): http://dx.doi.org/10.3934/microbiol.2019.3.232.
    10.3934/microbiol.2019.3.232
  66. Betina Lopez-Mila; Patrícia Alves; Tomáš Riedel; Barbara Dittrich; Filipe Mergulhão; Cesar Rodriguez-Emmenegger. "Effect of shear stress on the reduction of bacterial adhesion to antifouling polymers". Bioinspiration & Biomimetics 13 6 (2018): 065001-065001. https://doi.org/10.1088/1748-3190/aadcc2.
    10.1088/1748-3190/aadcc2
  67. Mergulhão, Filipe. "The effects of fluid composition and shear conditions on bacterial adhesion to an antifouling peptide-coated surface". MRS Communications (2018): http://dx.doi.org/10.1557/mrc.2018.160.
    10.1557/mrc.2018.160
  68. L.C. Gomes; J. Deschamps; R. Briandet; F.J. Mergulhão. "Impact of modified diamond-like carbon coatings on the spatial organization and disinfection of mixed-biofilms composed of Escherichia coli and Pantoea agglomerans industrial isolates". International Journal of Food Microbiology 277 (2018): 74-82. https://doi.org/10.1016/j.ijfoodmicro.2018.04.017.
    10.1016/j.ijfoodmicro.2018.04.017
  69. Mergulhão, Filipe. "Comparing the Recombinant Protein Production Potential of Planktonic and Biofilm Cells". Microorganisms (2018): http://www.mdpi.com/2076-2607/6/2/48.
    10.3390/microorganisms6020048
  70. L.C. Gomes; J.-C. Piard; R. Briandet; F.J. Mergulhão. "Pseudomonas grimontii biofilm protects food contact surfaces from Escherichia coli colonization". LWT - Food Science and Technology (2017): https://doi.org/10.1016%2Fj.lwt.2017.03.005.
    10.1016/j.lwt.2017.03.005
  71. J.M.R. Moreira; L.C. Gomes; K.A. Whitehead; S. Lynch; L.A. Tetlow; F.J. Mergulhão. "Effect of surface conditioning with cellular extracts on Escherichia coli adhesion and initial biofilm formation". Food and Bioproducts Processing 104 (2017): 1-12. https://doi.org/10.1016%2Fj.fbp.2017.03.008.
    10.1016/j.fbp.2017.03.008
  72. Luciana Calheiros Gomes; Filipe José Mergulhão. "SEM Analysis of Surface Impact on Biofilm Antibiotic Treatment". Scanning (2017):
    10.1155/2017/2960194
  73. Araújo, P.A.; Machado, I.; Meireles, A.; Leiknes, T.; Mergulhão, F.; Melo, L.F.; Simões, M.. "Combination of selected enzymes with cetyltrimethylammonium bromide in biofilm inactivation, removal and regrowth". Food Research International 95 (2017): 101-107. http://www.scopus.com/inward/record.url?eid=2-s2.0-85014941229&partnerID=MN8TOARS.
    10.1016/j.foodres.2017.02.016
  74. Gomes, L.C.; Mergulhão, F.J.. "Heterologous protein production in Escherichia coli biofilms: A non-conventional form of high cell density cultivation". Process Biochemistry 57 (2017): 1-8. http://www.scopus.com/inward/record.url?eid=2-s2.0-85017439544&partnerID=MN8TOARS.
    10.1016/j.procbio.2017.03.018
  75. Meireles, A.; Fulgêncio, R.; Machado, I.; Mergulhão, F.; Melo, L.; Simões, M.. "Characterization of the heterotrophic bacteria from a minimally processed vegetables plant". LWT - Food Science and Technology 85 (2017): 293-300. http://www.scopus.com/inward/record.url?eid=2-s2.0-85010878293&partnerID=MN8TOARS.
    10.1016/j.lwt.2017.01.038
  76. Gomes, L.C.; Mergulhão, F.J.. "Effects of antibiotic concentration and nutrient medium composition on Escherichia coli biofilm formation and green fluorescent protein expression". FEMS Microbiology Letters 364 5 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85018334955&partnerID=MN8TOARS.
    10.1093/femsle/fnx042
  77. Azevedo, A.S.; Almeida, C.; Gomes, L.C.; Ferreira, C.; Mergulhão, F.J.; Melo, L.F.; Azevedo, N.F.. "An in vitro model of catheter-associated urinary tract infections to investigate the role of uncommon bacteria on the Escherichia coli microbial consortium". Biochemical Engineering Journal 118 (2017): 64-69. http://www.scopus.com/inward/record.url?eid=2-s2.0-84998772458&partnerID=MN8TOARS.
    10.1016/j.bej.2016.11.013
  78. Costa, A.M.; Mergulhão, F.J.; Briandet, R.; Azevedo, N.F.. "It is all about location: How to pinpoint microorganisms and their functions in multispecies biofilms". Future Microbiology 12 11 (2017): 987-999. http://www.scopus.com/inward/record.url?eid=2-s2.0-85028548191&partnerID=MN8TOARS.
    10.2217/fmb-2017-0053
  79. Azeredo, J.; Azevedo, N.F.; Briandet, R.; Cerca, N.; Coenye, T.; Costa, A.R.; Desvaux, M.; et al. "Critical review on biofilm methods". Critical Reviews in Microbiology 43 3 (2017): 313-351. http://www.scopus.com/inward/record.url?eid=2-s2.0-85014963888&partnerID=MN8TOARS.
    10.1080/1040841x.2016.1208146
  80. Mergulhão, Filipe. "Surface conditioning with Escherichia coli cell wall components can reduce biofilm formation by decreasing initial adhesion". AIMS Microbiology (2017): http://dx.doi.org/10.3934/microbiol.2017.3.613.
    10.3934/microbiol.2017.3.613
  81. L.C. Gomes; D. Carvalho; R. Briandet; F.J. Mergulhão. "Temporal variation of recombinant protein expression in Escherichia coli biofilms analysed at single-cell level". Process Biochemistry 51 9 (2016): 1155-1161. https://doi.org/10.1016%2Fj.procbio.2016.05.016.
    10.1016/j.procbio.2016.05.016
  82. Gomes IB; Malheiro J; Mergulhão F; Maillard JY; Simões M. "Comparison of the efficacy of natural-based and synthetic biocides to disinfect silicone and stainless steel surfaces.". (2016): http://europepmc.org/abstract/med/26926153.
    10.1093/femspd/ftw014
  83. Araújo, P.A.; Malheiro, J.; MacHado, I.; Mergulhão, F.; Melo, L.; Simões, M.; Araujo, PA; et al. "Influence of flow velocity on the characteristics of pseudomonas fluorescens biofilms". Journal of Environmental Engineering (United States) 142 7 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84975247417&partnerID=MN8TOARS.
    10.1061/(ASCE)EE.1943-7870.0001068
  84. Moreira, J.M.R.; Fulgêncio, R.; Alves, P.; Machado, I.; Bialuch, I.; Melo, L.F.; Simões, M.; Mergulhão, F.J.. "Evaluation of SICAN performance for biofouling mitigation in the food industry". Food Control 62 (2016): 201-207. http://www.scopus.com/inward/record.url?eid=2-s2.0-84946595450&partnerID=MN8TOARS.
    10.1016/j.foodcont.2015.10.023
  85. Moreira, J.M.R.; Fulgêncio, R.; Oliveira, F.; Machado, I.; Bialuch, I.; Melo, L.F.; Simões, M.; Mergulhão, F.J.. "Evaluation of SICON® surfaces for biofouling mitigation in critical process areas". Food and Bioproducts Processing 98 (2016): 173-180. http://www.scopus.com/inward/record.url?eid=2-s2.0-84956686618&partnerID=MN8TOARS.
    10.1016/j.fbp.2016.01.009
  86. Gomes, LC; Mergulhao, FJ. "Effect of heterologous protein expression on Escherichia coli biofilm formation and biocide susceptibility". AIMS MICROBIOLOGY (2016):
    10.3934/microbiol.2016.4.434
  87. Machado, I.; Meireles, A.; Fulgêncio, R.; Mergulhão, F.; Simões, M.; Melo, L.F.. "Disinfection with neutral electrolyzed oxidizing water to reduce microbial load and to prevent biofilm regrowth in the processing of fresh-cut vegetables". Food and Bioproducts Processing 98 (2016): 333-340. http://www.scopus.com/inward/record.url?eid=2-s2.0-84961794771&partnerID=MN8TOARS.
    10.1016/j.fbp.2016.02.008
  88. Moreira, J.M.R.; Ponmozhi, J.; Campos, J.B.L.M.; Miranda, J.M.; Mergulhão, F.J.. "Micro- and macro-flow systems to study Escherichia coli adhesion to biomedical materials". Chemical Engineering Science 126 (2015): 440-445. http://dx.doi.org/10.1016/j.ces.2014.12.054.
    Accepted • 10.1016/j.ces.2014.12.054
  89. Malheiro, J.; Araújo, P.; Machado, I.; Lemos, M.; Mergulhão, F.; Melo, L.; Simões, M.. "The Effects of Selected Brominated and Chlorinated Chemicals on Pseudomonas Fluorescens Planktonic Cells and Flow-Generated Biofilms". Journal of Food Processing and Preservation (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84949257163&partnerID=MN8TOARS.
    10.1111/jfpp.12609
  90. Lemos, M.; Mergulhão, F.; Melo, L.; Simões, M.. "The effect of shear stress on the formation and removal of Bacillus cereus biofilms". Food and Bioproducts Processing 93 (2015): 242-248. http://www.scopus.com/inward/record.url?eid=2-s2.0-84956571746&partnerID=MN8TOARS.
    10.1016/j.fbp.2014.09.005
  91. Lemos, M.; Gomes, I.; Mergulhão, F.; Melo, L.; Simões, M.. "The effects of surface type on the removal of Bacillus cereus and Pseudomonas fluorescens single and dual species biofilms". Food and Bioproducts Processing 93 (2015): 234-241. http://www.scopus.com/inward/record.url?eid=2-s2.0-84956571748&partnerID=MN8TOARS.
    10.1016/j.fbp.2014.08.009
  92. Pogiatzis, T.A.; Vassiliadis, V.S.; Mergulhão, F.J.; Wilson, D.I.. "Choosing when to clean and how to clean biofilms in heat exchangers". Heat Transfer Engineering 36 (2015): 676-684. http://www.scopus.com/inward/record.url?eid=2-s2.0-84910656178&partnerID=MN8TOARS.
    10.1080/01457632.2015.954940
  93. Moreira, J.M.R.; Simões, M.; Melo, L.F.; Mergulhão, F.J.. "The combined effects of shear stress and mass transfer on the balance between biofilm and suspended cell dynamics". Desalination and Water Treatment 53 12 (2015): 3348-3354. http://www.scopus.com/inward/record.url?eid=2-s2.0-84923541231&partnerID=MN8TOARS.
    10.1080/19443994.2014.933625
  94. Gomes, L.C.; Silva, L.N.; Simões, M.; Melo, L.F.; Mergulhão, F.J.. "Escherichia coli adhesion, biofilm development and antibiotic susceptibility on biomedical materials". Journal of Biomedical Materials Research - Part A 103 4 (2015): 1414-1423. http://www.scopus.com/inward/record.url?eid=2-s2.0-84923575956&partnerID=MN8TOARS.
    10.1002/jbm.a.35277
  95. Moreira, J.M.R.; Gomes, L.C.; Simões, M.; Melo, L.F.; Mergulhão, F.J.. "The impact of material properties, nutrient load and shear stress on biofouling in food industries". Food and Bioproducts Processing 95 (2015): 228-236. http://www.scopus.com/inward/record.url?eid=2-s2.0-84934992919&partnerID=MN8TOARS.
    10.1016/j.fbp.2015.05.011
  96. Gomes LC; Moreira JM; Simões M; Melo LF; Mergulhão FJ. "Biofilm localization in the vertical wall of shaking 96-well plates.". (2014): http://europepmc.org/abstract/med/24834360.
    10.1155/2014/231083
  97. Lemos, M.; Borges, A.; Teodósio, J.; Araújo, P.; Mergulhão, F.; Melo, L.; Simões, M.. "The effects of ferulic and salicylic acids on Bacillus cereus and Pseudomonas fluorescens single- and dual-species biofilms". International Biodeterioration and Biodegradation 86 (2014): 42-51. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887023078&partnerID=MN8TOARS.
    10.1016/j.ibiod.2013.06.011
  98. Abreu, A.C.; Borges, A.; Mergulhão, F.; Simoes, M.. "Use of phenyl isothiocyanate for biofilm prevention and control". International Biodeterioration and Biodegradation 86 (2014): 34-41. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887029148&partnerID=MN8TOARS.
    10.1016/j.ibiod.2013.03.024
  99. Meireles, A.; Machado, I.; Fulgêncio, R.; Mergulhão, F.; Melo, L.; Simões, M.. "Efficacy of antimicrobial combinations to reduce the use of sodium hypochlorite in the control of planktonic and sessile Escherichia coli". Biochemical Engineering Journal (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84924912155&partnerID=MN8TOARS.
    10.1016/j.bej.2015.02.035
  100. Gomes, L.C.; Moreira, J.M.R.; Teodósio, J.S.; Araújo, J.D.P.; Miranda, J.M.; Simões, M.; Melo, L.F.; Mergulhão, F.J.. "96-well microtiter plates for biofouling simulation in biomedical settings". Biofouling 30 5 (2014): 535-546. http://www.scopus.com/inward/record.url?eid=2-s2.0-84900026049&partnerID=MN8TOARS.
    10.1080/08927014.2014.890713
  101. Moreira, J.M.R.; Araújo, J.D.P.; Miranda, J.M.; Simões, M.; Melo, L.F.; Mergulhão, F.J.. "The effects of surface properties on escherichia coli adhesion are modulated by shear stress". Colloids and Surfaces B: Biointerfaces 123 (2014): 1-7. http://www.scopus.com/inward/record.url?eid=2-s2.0-84908539622&partnerID=MN8TOARS.
    10.1016/j.colsurfb.2014.08.016
  102. Araújo, P.A.; Mergulhão, F.; Melo, L.; Simões, M.. "The ability of an antimicrobial agent to penetrate a biofilm is not correlated with its killing or removal efficiency". Biofouling 30 6 (2014): 675-683. http://www.scopus.com/inward/record.url?eid=2-s2.0-84902546839&partnerID=MN8TOARS.
    10.1080/08927014.2014.904294
  103. Moreira, J.M.R.; Simões, M.; Melo, L.F.; Mergulhão, F.J.. "Escherichia coli adhesion to surfaces–a thermodynamic assessment". Colloid and Polymer Science 293 1 (2014): 177-185. http://www.scopus.com/inward/record.url?eid=2-s2.0-84925513387&partnerID=MN8TOARS.
    10.1007/s00396-014-3390-x
  104. Araújo PA; Lemos M; Mergulhão F; Melo L; Simões M. "The Influence of Interfering Substances on the Antimicrobial Activity of Selected Quaternary Ammonium Compounds.". (2013): http://europepmc.org/abstract/med/26904590.
    10.1155/2013/237581
  105. Gomes, L.C.; Moreira, J.M.R.; Miranda, J.M.; Simões, M.; Melo, L.F.; Mergulhão, F.J.. "Macroscale versus microscale methods for physiological analysis of biofilms formed in 96-well microtiter plates". Journal of Microbiological Methods 95 3 (2013): 342-349. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886809883&partnerID=MN8TOARS.
    10.1016/j.mimet.2013.10.002
  106. Moreira, J.M.R.; Gomes, L.C.; Araújo, J.D.P.; Miranda, J.M.; Simões, M.; Melo, L.F.; Mergulhão, F.J.. "The effect of glucose concentration and shaking conditions on Escherichia coli biofilm formation in microtiter plates". Chemical Engineering Science 94 (2013): 192-199. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875583286&partnerID=MN8TOARS.
    10.1016/j.ces.2013.02.045
  107. Teodósio, J.S.; Silva, F.C.; Moreira, J.M.R.; Simões, M.; Melo, L.F.; Alves, M.A.; Mergulhão, F.J.. "Flow cells as quasi-ideal systems for biofouling simulation of industrial piping systems". Biofouling 29 8 (2013): 953-966. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883653767&partnerID=MN8TOARS.
    10.1080/08927014.2013.821467
  108. Moreira, J.M.R.; Teodósio, J.S.; Silva, F.C.; Simões, M.; Melo, L.F.; Mergulhão, F.J.. "Influence of flow rate variation on the development of Escherichia coli biofilms". Bioprocess and Biosystems Engineering 36 11 (2013): 1787-1796. http://www.scopus.com/inward/record.url?eid=2-s2.0-84892373974&partnerID=MN8TOARS.
    10.1007/s00449-013-0954-y
  109. Abreu, A.C.; Tavares, R.R.; Borges, A.; Mergulhão, F.; Simões, M.. "Current and emergent strategies for disinfection of hospital environments". Journal of Antimicrobial Chemotherapy 68 12 (2013): 2718-2732. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887514856&partnerID=MN8TOARS.
    10.1093/jac/dkt281
  110. Teodósio, J.S.; Simões, M.; Mergulhão, F.J.. "The influence of nonconjugative Escherichia coli plasmids on biofilm formation and resistance". Journal of Applied Microbiology 113 2 (2012): 373-382. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864005856&partnerID=MN8TOARS.
    10.1111/j.1365-2672.2012.05332.x
  111. Teodósio, J.S.; Simões, M.; Alves, M.A.; Melo, L.F.; Mergulhão, F.J.. "Setup and validation of flow cell systems for biofouling simulation in industrial settings". The Scientific World Journal 2012 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84871938448&partnerID=MN8TOARS.
    10.1100/2012/361496
  112. Teodósio, J.S.; Simões, M.; Melo, L.F.; Mergulhão, F.J.. "Flow cell hydrodynamics and their effects on E. coli biofilm formation under different nutrient conditions and turbulent flow". Biofouling 27 1 (2011): 1-11. http://www.scopus.com/inward/record.url?eid=2-s2.0-78449260750&partnerID=MN8TOARS.
    10.1080/08927014.2010.535206
  113. Carapuça, E.; Azzoni, A.R.; Prazeres, D.M.F.; Monteiro, G.A.; Mergulhão, F.J.M.. "Time-course determination of plasmid content in eukaryotic and prokaryotic cells using Real-Time PCR". Molecular Biotechnology 37 2 (2007): 120-126. http://www.scopus.com/inward/record.url?eid=2-s2.0-34248999538&partnerID=MN8TOARS.
    10.1007/s12033-007-0007-3
  114. Mergulhão, F.J.; Monteiro, G.A.. "Analysis of factors affecting the periplasmic production of recombinant proteins in Escherichia coli". Journal of Microbiology and Biotechnology 17 8 (2007): 1236-1241. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548502969&partnerID=MN8TOARS.
  115. Mergulhão, F.J.M.; Summers, D.K.; Monteiro, G.A.. "Recombinant protein secretion in Escherichia coli". Biotechnology Advances 23 3 (2005): 177-202. http://www.scopus.com/inward/record.url?eid=2-s2.0-14844283810&partnerID=MN8TOARS.
    10.1016/j.biotechadv.2004.11.003
  116. Mergulhão, F.J.M.; Monteiro, G.A.. "Secretion capacity limitations of the Sec pathway in Escherichia coli". Journal of Microbiology and Biotechnology 14 1 (2004): 128-133. http://www.scopus.com/inward/record.url?eid=2-s2.0-1542285366&partnerID=MN8TOARS.
  117. Mergulhão, F.J.M.; Monteiro, G.A.; Cabral, J.M.S.; Taipa, M.A.. "Design of bacterial vector systems for the production of recombinant proteins in Escherichia coli". Journal of Microbiology and Biotechnology 14 1 (2004): 1-14. http://www.scopus.com/inward/record.url?eid=2-s2.0-1542285371&partnerID=MN8TOARS.
  118. Mergulhão, F.J.M.; Taipa, M.A.; Cabral, J.M.S.; Monteiro, G.A.. "Evaluation of bottlenecks in proinsulin secretion by Escherichia coli". Journal of Biotechnology 109 1-2 (2004): 31-43. http://www.scopus.com/inward/record.url?eid=2-s2.0-1842425886&partnerID=MN8TOARS.
    10.1016/j.jbiotec.2003.10.024
  119. Mergulhão, F.J.M.; Monteiro, G.A.; Larsson, G.; Bostrom, M.; Farewell, A.; Nyström, T.; Cabral, J.M.S.; Taipa, M.A.. "Evaluation of inducible promoters on the secretion of a ZZ-proinsulin fusion protein in Escherichia coli". Biotechnology and Applied Biochemistry 38 1 (2003): 87-93. http://www.scopus.com/inward/record.url?eid=2-s2.0-0042591085&partnerID=MN8TOARS.
    10.1042/BA20030043
  120. Mergulhão, F.J.M.; Monteiro, G.A.; Larsson, G.; Sandén, A.M.; Farewell, A.; Nystrom, T.; Cabral, J.M.S.; Taipa, M.A.. "Medium and copy number effects on the secretion of human proinsulin in Escherichia coli using the universal stress promoters uspA and uspB". Applied Microbiology and Biotechnology 61 5-6 (2003): 495-501. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037899027&partnerID=MN8TOARS.
    10.1007/s00253-003-1232-8
  121. Mergulhão, F.J.M.; Monteiro, G.A.; Cabral, J.M.S.; Taipa, M.A.. "A quantitative ELISA for monitoring the secretion of ZZ-fusion proteins using SpA domain as immunodetection reporter system". Applied Biochemistry and Biotechnology - Part B Molecular Biotechnology 19 3 (2001): 239-244. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035168991&partnerID=MN8TOARS.
    10.1385/mb:19:3:239
  122. Mergulhao, F.J.M.; Monteiro, G.A.; Kelly, A.G.; Taipa, M.A.; Joaquim, M.S.C.. "Recombinant human proinsulin: A new approach in gene assembly and protein expression". Journal of Microbiology and Biotechnology 10 5 (2000): 690-693. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033757725&partnerID=MN8TOARS.
  123. Mergulhão, F.J.M.; Kelly, A.G.; Monteiro, G.A.; Taipa, M.A.; Cabral, J.M.S.. "Troubleshooting in gene splicing by overlap extension: A step-wise method". Applied Biochemistry and Biotechnology - Part B Molecular Biotechnology 12 3 (1999): 285-287. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033428016&partnerID=MN8TOARS.
    10.1385/mb:12:3:285

Other

Other output
  1. Recombinant Protein Production and Plasmid Stability in Escherichia coli Biofilms. 2020. Gomes, LC; Monteiro, GA; Mergulhão, FJ.
    10.5194/biofilms9-65
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2013/07/22 - Current Evaluation of bacterial adhesion on carbon nanotube-poly (dimethysiloxane) composite materials
Supervisor
 Bioengenharia (Master)
Universidade do Porto Faculdade de Engenharia, Portugal
2013/07/08 - Current Biofouling and cleaning of microchannels
Co-supervisor
 Engenharia Química e Biológica (PhD)
Universidade do Porto Faculdade de Engenharia, Portugal
2011/10/09 - Current Biofilm control with antimicrobial agents: the role of the exopolymeric matrix
Co-supervisor
 Engenharia Química e Biológica (PhD)
Universidade do Porto Faculdade de Engenharia, Portugal
2019 - 2019 Optimizing Recombinant Protein Production in Escherichia coli biofilms
Supervisor
 Engenharia Química e Biológica (PhD)
Universidade do Porto Faculdade de Engenharia, Portugal
2019 - 2019 Marine biofilm formed by coccoid cyanobacteria: Development and Control
Supervisor
 Engenharia Química e Biológica (PhD)
Universidade do Porto Faculdade de Engenharia, Portugal
2019 - 2019 Effects of Dedicated Yeasts as Starter Culture Candidates on the Microbial Community and Metabolite Profiles of Cocoa Pulp-Bean Mass Fermentation Processes
Supervisor
 Bioengenharia (Master)
Universidade do Porto Faculdade de Engenharia, Portugal
2017 - 2017 Estudo Comparativo de Métodos de Doseamento de Proteína em Preparações de Imunoglobulina Humana Intravenosa
Supervisor
 Engenharia Química (Master)
Universidade do Porto Faculdade de Engenharia, Portugal
2017 - 2017 Characterization of marine biofilms formed by filamentous cyanobacteria
Supervisor
 Engenharia Química e Biológica (PhD)
Universidade do Porto Faculdade de Engenharia, Portugal
2017 - 2017 Evaluation of Escherichia coli biofilms in controlled hydrodynamic conditions using flow cells
Supervisor
 Engenharia Química e Biológica (PhD)
Universidade do Porto Faculdade de Engenharia, Portugal
2016 - 2016 Cloning and expression of a new ketoreductase from the marine bacteria Virgibacillus pantothenticus
Supervisor
 Bioengenharia (Master)
Universidade do Porto Faculdade de Engenharia, Portugal
2015 - 2015 Avaliação da influência de células humanas e não-humanas no desenvolvimento de linhas celulares estáveis para produção de TribodyTM5
Supervisor
 Engenharia Química (Master)
Universidade do Porto Faculdade de Engenharia, Portugal
2015 - 2015 Marine biofilms - how do they start?
Supervisor
 Bioengenharia (Master)
Universidade do Porto Faculdade de Engenharia, Portugal
2013 - 2013 The effect of biofilm formation on recombinant protein expression
Supervisor
 Engenharia Química e Biológica (PhD)
Universidade do Porto Faculdade de Engenharia, Portugal
2012 - 2012 Analysis of factors controlling the onset of bacterial biofilms
Supervisor
 Engenharia Química e Biológica (PhD)
Universidade do Porto Faculdade de Engenharia, Portugal
2011 - 2011 The interaction between recombinant protein production and biofilm formation and stability
Supervisor
 Engenharia Química e Biológica (PhD)
Universidade do Porto Faculdade de Engenharia, Portugal
Distinctions

Award

2011 Fulbright Scholar Program
Fulbright Association, United States