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Miguel Xavier Jesus Josefat Fernandes obtained his Ph.D. in Biochemistry in 2000 from the University of Lisbon He is a researcher at the Universidad de La Laguna, Tenerife, Spain. He works in the area of Biochemistry, and his research interests include molecular modelling, drug design, anti-cancer therapy, rare diseases, multidrug resistance, and translational research. From 2017 to 2021, he has published 15 scientific papers, submitted 2 patents applications, and led 3 projects with a total funding of 463,300€. Currentlly, a company he founded in 2016 has one of its compounds undergoing Phase I clinical trials.
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Identification

Personal identification

Full name
Miguel Xavier Jesus Josefat Fernandes

Citation names

  • Fernandes, Miguel X

Author identifiers

Ciência ID
ED1D-3C7A-467C
ORCID iD
0000-0002-1840-616X

Knowledge fields

  • Natural sciences - Biological Sciences - Biochemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Spanish; Castilian Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
French Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
German Elementary (A2) Elementary (A2) Elementary (A2) Elementary (A2) Elementary (A2)
Education
Degree Classification
2015/10 - 2016/07
Concluded
 Master in Business Administration (Master)
ECN - Canary Business School, Spain
2000
Concluded
 Bioquímica (Doutoramento)
Universidade de Lisboa, Portugal
"A Determinação de Propriedades Estruturais, Conformacionais e Dinâmicas em Moléculas em Sistemas Modelo de Membranas e em Solução [texto Policopiado] : Estudos de Simulação por Dinâmica Browniana" (THESIS/DISSERTATION)
 Cum Laude
1992
Concluded
 Bioquímica (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
 16
Affiliation

Science

Category
Host institution 		Employer
2018/01 - Current Contracted Researcher (Research) Universidad de La Laguna, Spain
Universidad de La Laguna Instituto Universitario de Bio-Orgánica Antonio González, Spain
2016 - 2016 Science and Technology Management Fundación General Universidad de La Laguna, Spain
Fundación General Universidad de La Laguna, Spain
2013 - 2015 Contracted Researcher (Research) Universidad de La Laguna, Spain
Universidad de La Laguna Instituto Universitario de Bio-Orgánica Antonio González, Spain
2003 - 2004/08/31 Contracted Researcher (Research) University of Maryland Biotechnology Institute, United States
Institute for Bioscience and Biotechnology Research Shady Grove, United States

Teaching in Higher Education

Category
Host institution 		Employer
2004/09/01 - 2016/11/30 Assistant Professor (University Teacher) Universidade da Madeira, Portugal

Positions / Appointments

Category
Host institution 		Employer
2009/04 - 2013/04 Vice-Rector Universidade da Madeira, Portugal
2004 - 2009 Director de Curso da Licenciatura em Bioquímica Universidade da Madeira, Portugal

Others

Category
Host institution 		Employer
2016 - 2018 Chief Executive Officer and Chief Scientific Officer Orfan Biotech SL, Spain
Orfan Biotech SL, Spain
Projects

Grant

Designation Funders
2001/01/01 - 2003/12/31 Estudos de propriedades estruturais, cinéticas e químicas da associação difusiva proteína-proteína por simulação computacional de Dinâmica Browniana - utilização de modelos detalhados
SFRH/BPD/3594/2000
Post-doc Fellow
Universidad de Murcia Facultad de Química, Spain
 Fundação para a Ciência e a Tecnologia
Concluded
1996/10/01 - 2000/07/31 Estudo da estrutura e dinâmica de sistemas membranares heterogéneos envolvidos em novos transportadores moleculares e formulações inovadoras de vacinas
PRAXIS XXI/BD/9393/96
PhD Student Fellow
Universidade de Lisboa Faculdade de Ciências, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2020/01 - Current FARMACAN - Early pharmacological profile of marine natural products from the Canary biodiversity
EIS-2020-06
Researcher
Universidad de La Laguna Instituto Universitario de Bio-Orgánica Antonio González, Spain
 Gobierno de Canarias Consejería de Economía Industria Comercio y Conocimiento
2020/01 - Current TheraPanc - New Therapeutic Strategies for the Treatment of Pancreatic Cancer
ProID2020010101
Researcher
Universidad de La Laguna Instituto Universitario de Bio-Orgánica Antonio González, Spain
 Gobierno de Canarias Consejería de Economía Industria Comercio y Conocimiento
2019/01 - Current Sustainable chemistry: from small molecules to complex functional systems
PGC2018-094503-B-C22
Researcher
Universidad de La Laguna Instituto Universitario de Bio-Orgánica Antonio González, Spain
 Ministerio de Ciencia, Innovación y Universidades
Ongoing
2018/09 - Current STRATAGEM - New diagnostic and therapeutic tools against multidrug resistant tumors
CA17104
Researcher
Universidad de La Laguna Instituto Universitario de Bio-Orgánica Antonio González, Spain
 European Cooperation in Science and Technology
2016/04 - Current MuTaLig - Multi-target paradigm for innovative ligand identification in the drug discovery process
CA15135
Researcher
Universidad de La Laguna Instituto Universitario de Bio-Orgánica Antonio González, Spain
 European Cooperation in Science and Technology
Concluded
2018/01 - 2022/01 MetaPanc: glutamine metabolism inhibition as therapy against pancreatic ductal adenocarcinoma
ULL.ADB.17
Principal investigator
Universidad de La Laguna Instituto Universitario de Bio-Orgánica Antonio González, Spain
 Cabildo de Tenerife
Concluded
2019 - 2022 Development of LDHA inhibitors as a new strategy in the treatment of primary hyperoxaluria
RTI2018-098560-B-C22
Researcher
Universidad de La Laguna Instituto Universitario de Bio-Orgánica Antonio González, Spain
 España Ministerio de Ciencia e Innovación
2020/01/01 - 2021/06/30 Development of a new technology for acceleration of preclinical drug trials.
EATIC2020010065
Principal investigator
Orfan Biotech SL, Spain
 Agencia Canaria de Investigación Innovación y Sociedad de la Información
Concluded
2016/01 - 2019/12 Molecular substrate reduction therapy for Primary Hyperoxaluria
SAF2015-69796-C2-1-R
Researcher
Gobierno de España
2017/01/01 - 2018/06/30 Incorporation of new technology for the production of iPS cells derived from somatic cells of patients with Primary Hyperoxaluria type 1, PH1, to accelerate the transfer of R&D results to the market.
EATIC2017010042
Principal investigator
Orfan Biotech SL, Spain
 Agencia Canaria de Investigación Innovación y Sociedad de la Información
Concluded
2014/06 - 2016/11 BIOTRANSFER: Transfer of biotechnology research results oriented towards business profitability and mobilization of business flows
MAC/1/M041
Researcher
Universidad de La Laguna Instituto Universitario de Bio-Orgánica Antonio González, Spain
 European Regional Development Fund
Concluded
2013/07/01 - 2016/02/29 Optimização de moduladores da glicoproteína-P e investigação do mecanismo de efluxo
PTDC/QEQ-MED/0905/2012
Researcher
Universidade da Madeira, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2014/01/01 - 2015/11/30 Molecular basis of aldosterone multi-systemic effects: keys for news therapeutic approaches for mineralocorticoid physiopathology
BFU2013-47089R
Researcher
Universidad de La Laguna Instituto de Tecnologías Biomédicas, Spain
 Ministerio de Economía y Competitividad
Concluded
2013/10/01 - 2015/11/30 IMBRAIN: Improving Biomedical Research and Innovation in the Canary Islands
FP7-REGPOT-2012-CT2012-316137
Researcher
Universidad de La Laguna, Spain
 European Commission
2011/04/01 - 2014/09/30 DENDRIMAT - Novos materiais para a entrega de fármacos/genes baseados na auto-montagem de conjugados dendrímero-quitosano-DNA de cadeia simples
PTDC/CTM-NAN/112428/2009
Researcher
Universidade da Madeira, Portugal

Universidade da Madeira Centro de Química da Madeira, Portugal

Instituto Nacional de Engenharia Biomédica, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/04/01 - 2014/09/30 Estudos funcionais, moleculares e farmacológicos das proteínas da família p53: da levedura às células humanas
PTDC/SAU-FAR/110848/2009
Researcher
Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade do Porto Faculdade de Farmácia, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Universidade da Madeira, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/04/01 - 2014/03/31 Diterpenos como protótipos na reversão da multirresistência em células tumorais: moduladores da glicoproteína-P e agentes antiproliferativos
PTDC/QUI-QUI/099815/2008
Researcher
Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade da Madeira, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2009/09 - 2013/03 BIOPHARMAC - Knowledge based development of biotechnology and pharmacy industries based upon the biodiversity of Macaronesia
MAC/1/C104
Researcher
Universidade da Madeira Centro de Química da Madeira, Portugal
 European Regional Development Fund
Concluded
Outputs

Publications

Journal article
  1. Fuentes-Aguilar, A.; Merino-Montiel, P.; Montiel-Smith, S.; Meza-Reyes, S.; Vega-Báez, J.L.; Puerta, A.; Fernandes, M.X.; et al. "2-Aminobenzoxazole-appended coumarins as potent and selective inhibitors of tumour-associated carbonic anhydrases". Journal of Enzyme Inhibition and Medicinal Chemistry 37 1 (2022): 168-177. http://www.scopus.com/inward/record.url?eid=2-s2.0-85121301860&partnerID=MN8TOARS.
    10.1080/14756366.2021.1998026
  2. Ahuja-Casarín, A.I.; Merino-Montiel, P.; Vega-Baez, J.L.; Montiel-Smith, S.; Fernandes, M.X.; Lagunes, I.; Maya, I.; et al. "Tuning the activity of iminosugars: novel N-alkylated deoxynojirimycin derivatives as strong BuChE inhibitors". Journal of Enzyme Inhibition and Medicinal Chemistry 36 1 (2021): 138-146. http://www.scopus.com/inward/record.url?eid=2-s2.0-85096537426&partnerID=MN8TOARS.
    10.1080/14756366.2020.1847101
  3. Moya-Garzon, M.D.; Gomez-Vidal, J.A.; Alejo-Armijo, A.; Altarejos, J.; Rodriguez-Madoz, J.R.; Fernandes, M.X.; Salido, E.; Salido, S.; Diaz-Gavilan, M.. "Small molecule-based enzyme inhibitors in the treatment of primary hyperoxalurias". Journal of Personalized Medicine 11 2 (2021): 1-31. http://www.scopus.com/inward/record.url?eid=2-s2.0-85100516366&partnerID=MN8TOARS.
    10.3390/jpm11020074
  4. Dinic, J.; Ríos-Luci, C.; Karpaviciene, I.; Cikotiene, I.; Fernandes, M.X.; Pešic, M.; Padrón, J.M.. "CKT0353, a novel microtubule targeting agent, overcomes paclitaxel induced resistance in cancer cells". Investigational New Drugs 38 3 (2020): 584-598. http://www.scopus.com/inward/record.url?eid=2-s2.0-85067282745&partnerID=MN8TOARS.
    10.1007/s10637-019-00803-6
  5. "Inhibition of glutamine metabolism as a therapeutic approach against pancreatic ductal adenocarcinoma". Journal of Molecular and Clinical Medicine 2 4 (2019): 97-97. http://dx.doi.org/10.31083/j.jmcm.2019.04.5121.
    10.31083/j.jmcm.2019.04.5121
  6. Perestrelo, R.; Silva, C.; Fernandes, M.X.; Câmara, J.S.. "Prediction of terpenoid toxicity based on a quantitative structure–activity relationship model". Foods 8 12 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85077660016&partnerID=MN8TOARS.
    10.3390/foods8120628
  7. Lagunes, I.; Begines, P.; Silva, A.; Galán, A.R.; Puerta, A.; Fernandes, M.X.; Maya, I.; et al. "Selenocoumarins as new multitarget antiproliferative agents: Synthesis, biological evaluation and in silico calculations". European Journal of Medicinal Chemistry 179 (2019): 493-501. http://www.scopus.com/inward/record.url?eid=2-s2.0-85068104440&partnerID=MN8TOARS.
    10.1016/j.ejmech.2019.06.073
  8. "Naphthol-derived Betti bases as potential SLC6A14 blockers". Journal of Molecular and Clinical Medicine 2 2 (2019): 35-35. http://dx.doi.org/10.31083/j.jmcm.2019.02.7181.
    10.31083/j.jmcm.2019.02.7181
  9. Rodriguez-Rodriguez, A.E.; Donate-Correa, J.; Rovira, J.; Cuesto, G.; Luis-Ravelo, D.; Fernandes, M.X.; Acevedo-Arozena, A.; et al. "Inhibition of the mTOR pathway: A new mechanism of ß cell toxicity induced by tacrolimus". American Journal of Transplantation 19 12 (2019): 3240-3249. http://www.scopus.com/inward/record.url?eid=2-s2.0-85068801477&partnerID=MN8TOARS.
    10.1111/ajt.15483
  10. Serina, J.; Fernandes, M.X.; Castilho, P.C.. "Effects of hydroxycinnamic acids on the glycolysis pathway". South African Journal of Botany 120 (2019): 219-229. http://www.scopus.com/inward/record.url?eid=2-s2.0-85049473853&partnerID=MN8TOARS.
    10.1016/j.sajb.2018.06.016
  11. "Facts and myths of selective casein kinase 1e einhibition". Journal of Molecular and Clinical Medicine 1 4 (2018): http://dx.doi.org/10.31083/j.jmcm.2018.04.401.
    10.31083/j.jmcm.2018.04.401
  12. "A Small Molecule Tubulin Depolymerizing Agent Identi¿ed by a Phenotypic Drug Discovery Approach". Journal of Molecular and Clinical Medicine 1 2 (2018): http://dx.doi.org/10.31083/j.jmcm.2018.02.003.
    10.31083/j.jmcm.2018.02.003
  13. "Differential mechanism of action of the CK1e inhibitor GSD0054". Journal of Molecular and Clinical Medicine 1 2 (2018): http://dx.doi.org/10.31083/j.jmcm.2018.02.004.
    10.31083/j.jmcm.2018.02.004
  14. Sharma, M.G.; Vala, R.M.; Patel, D.M.; Lagunes, I.; Fernandes, M.X.; Padrón, J.M.; Ramkumar, V.; Gardas, R.L.; Patel, H.M.. "Anti-Proliferative 1,4-Dihydropyridine and Pyridine Derivatives Synthesized through a Catalyst-Free, One-Pot Multi-Component Reaction". ChemistrySelect 3 43 (2018): 12163-12168. http://www.scopus.com/inward/record.url?eid=2-s2.0-85057018343&partnerID=MN8TOARS.
    10.1002/slct.201802537
  15. Moya-Garzón, M.D.; Martín Higueras, C.; Peñalver, P.; Romera, M.; Fernandes, M.X.; Franco-Montalbán, F.; Gómez-Vidal, J.A.; Salido, E.; Díaz-Gavilán, M.. "Salicylic Acid Derivatives Inhibit Oxalate Production in Mouse Hepatocytes with Primary Hyperoxaluria Type 1". Journal of Medicinal Chemistry 61 16 (2018): 7144-7167. http://www.scopus.com/inward/record.url?eid=2-s2.0-85050596301&partnerID=MN8TOARS.
    10.1021/acs.jmedchem.8b00399
  16. "Caffeoylquinic acids as inhibitors for HIV-I protease and HIV-I Integrase. A Molecular docking study". SDRP Journal of Computational Chemistry & Molecular Modelling 1 2 (2017): http://dx.doi.org/10.25177/jccmm.1.2.1.
    10.25177/jccmm.1.2.1
  17. Podolski-Renic, A.; Bankovic, J.; Dinic, J.; Ríos-Luci, C.; Fernandes, M.X.; Ortega, N.; Kovacevic-Grujicic, N.; et al. "DTA0100, dual topoisomerase II and microtubule inhibitor, evades paclitaxel resistance in P-glycoprotein overexpressing cancer cells". European Journal of Pharmaceutical Sciences 105 (2017): 159-168. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019439523&partnerID=MN8TOARS.
    10.1016/j.ejps.2017.05.011
  18. Baptista, R.; Ferreira, R.J.; Dos Santos, D.J.V.A.; Fernandes, M.X.; Ferreira, M.-J.U.. "Optimizing the macrocyclic diterpenic core toward the reversal of multidrug resistance in cancer". Future Medicinal Chemistry 8 6 (2016): 629-645. http://www.scopus.com/inward/record.url?eid=2-s2.0-84966473176&partnerID=MN8TOARS.
    10.4155/fmc.16.11
  19. Jiménez-Canino, R.; Fernandes, M.X.; De La Rosa, D.A.. "Phosphorylation of mineralocorticoid receptor ligand binding domain impairs receptor activation and has a dominant negative effect over non-phosphorylated receptors". Journal of Biological Chemistry 291 36 (2016): 19068-19078. http://www.scopus.com/inward/record.url?eid=2-s2.0-84984889397&partnerID=MN8TOARS.
    10.1074/jbc.M116.718395
  20. Silveira-Dorta, G.; Sousa, I.J.; Fernandes, M.X.; Martín, V.S.; Padrón, J.M.. "Synthesis and identification of unprecedented selective inhibitors of CK1e". European Journal of Medicinal Chemistry 96 (2015): 308-317. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928012550&partnerID=MN8TOARS.
    10.1016/j.ejmech.2015.03.046
  21. Ramalhete, C.; Da Cruz, F.P.; Mulhovo, S.; Sousa, I.J.; Fernandes, M.X.; Prudêncio, M.; Ferreira, M.-J.U.. "Dual-stage triterpenoids from an African medicinal plant targeting the malaria parasite". Bioorganic and Medicinal Chemistry 22 15 (2014): 3887-3890. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905560275&partnerID=MN8TOARS.
    10.1016/j.bmc.2014.06.019
  22. Sousa, I.J.; Ferreira, M.-J.U.; Molnár, J.; Fernandes, M.X.. "QSAR studies of macrocyclic diterpenes with P-glycoprotein inhibitory activity". European Journal of Pharmaceutical Sciences 48 3 (2013): 542-553. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872528917&partnerID=MN8TOARS.
    10.1016/j.ejps.2012.11.012
  23. Lima, R.T.; Seca, H.; Palmeira, A.; Fernandes, M.X.; Castro, F.; Correia-da-Silva, M.; Nascimento, M.S.J.; et al. "Sulfated small molecules targeting EBV in Burkitt lymphoma: From in silico screening to the evidence of in vitro effect on viral episomal DNA". Chemical Biology and Drug Design 81 5 (2013): 631-644. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876827905&partnerID=MN8TOARS.
    10.1111/cbdd.12109
  24. Leão, M.; Pereira, C.; Bisio, A.; Ciribilli, Y.; Paiva, A.M.; Machado, N.; Palmeira, A.; et al. "Discovery of a new small-molecule inhibitor of p53-MDM2 interaction using a yeast-based approach". Biochemical Pharmacology 85 9 (2013): 1234-1245. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875712215&partnerID=MN8TOARS.
    10.1016/j.bcp.2013.01.032
  25. Sousa, I.J.; Padrón, J.M.; Fernandes, M.X.. "Generation of artificial neural networks models in anticancer study". Neural Computing and Applications 23 3-4 (2013): 577-582. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884587605&partnerID=MN8TOARS.
    10.1007/s00521-013-1404-0
  26. Silveira-Dorta, G.; Sousa, I.J.; Ríos-Luci, C.; Martín, V.S.; Fernandes, M.X.; Padrón, J.M.. "Molecular docking studies of the interaction between propargylic enol ethers and human DNA topoisomerase IIa". Bioorganic and Medicinal Chemistry Letters 23 19 (2013): 5382-5384. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883489958&partnerID=MN8TOARS.
    10.1016/j.bmcl.2013.07.055
  27. Fernandes, C.; Tiritan, M.E.; Cass, Q.; Kairys, V.; Fernandes, M.X.; Pinto, M.. "Enantioseparation and chiral recognition mechanism of new chiral derivatives of xanthones on macrocyclic antibiotic stationary phases". Journal of Chromatography A 1241 (2012): 60-68. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860674472&partnerID=MN8TOARS.
    10.1016/j.chroma.2012.04.011
  28. Palmeira, A.; Sousa, E.; Helena Vasconcelos, M.; Pinto, M.; Fernandes, M.X.. "Structure and Ligand-based design of P-glycoprotein inhibitors: A historical perspective". Current Pharmaceutical Design 18 27 (2012): 4197-4214. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866309751&partnerID=MN8TOARS.
    10.2174/138161212802430530
  29. Alves, C.S.; Kairys, V.; Castanho, M.A.; Fernandes, M.X.. "Interaction of antimicrobial peptides, BP100 and pepR, with model membrane systems as explored by Brownian dynamics simulations on a coarse-grained model.". Biopolymers 98 4 (2012): 294-312. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872014492&partnerID=MN8TOARS.
  30. Palmeira, A.; Vasconcelos, M.H.; Paiva, A.; Fernandes, M.X.; Pinto, M.; Sousa, E.. "Dual inhibitors of P-glycoprotein and tumor cell growth: (Re)discovering thioxanthones". Biochemical Pharmacology 83 1 (2012): 57-68. http://www.scopus.com/inward/record.url?eid=2-s2.0-81855198003&partnerID=MN8TOARS.
    10.1016/j.bcp.2011.10.004
  31. Palmeira, A.; Rodrigues, F.; Sousa, E.; Pinto, M.; Vasconcelos, M.H.; Fernandes, M.X.. "New uses for old drugs: Pharmacophore-based screening for the discovery of P-glycoprotein inhibitors". Chemical Biology and Drug Design 78 1 (2011): 57-72. http://www.scopus.com/inward/record.url?eid=2-s2.0-79958812376&partnerID=MN8TOARS.
    10.1111/j.1747-0285.2011.01089.x
  32. Lather, V.; Fernandes, M.X.. "Comparative QSAR analyses of competitive CYP2C9 inhibitors using three-dimensional molecular descriptors". Chemical Biology and Drug Design 78 1 (2011): 112-123. http://www.scopus.com/inward/record.url?eid=2-s2.0-79958865966&partnerID=MN8TOARS.
    10.1111/j.1747-0285.2011.01106.x
  33. Palmeira, A.; Sousa, E.; Fernandes, M.X.; Pinto, M.M.; Helena Vasconcelos, M.. "Multidrug resistance reversal effects of aminated thioxanthones and interaction with cytochrome P450 3A4". Journal of Pharmacy and Pharmaceutical Sciences 15 1 (2011): 31-45. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856137888&partnerID=MN8TOARS.
  34. Palmeira, A.; Paiva, A.; Sousa, E.; Seca, H.; Almeida, G.M.; Lima, R.T.; Fernandes, M.X.; Pinto, M.; Vasconcelos, M.H.. "Insights into the in vitro antitumor mechanism of action of a new pyranoxanthone". Chemical Biology and Drug Design 76 1 (2010): 43-58. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953008434&partnerID=MN8TOARS.
    10.1111/j.1747-0285.2010.00978.x
  35. Alves, C.S.; Melo, M.N.; Franquelim, H.G.; Ferre, R.; Planas, M.; Feliu, L.; Bardají, E.; et al. "Escherichia coli cell surface perturbation and disruption induced by antimicrobial peptides BP100 and pepR". Journal of Biological Chemistry 285 36 (2010): 27536-27544. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956238793&partnerID=MN8TOARS.
    10.1074/jbc.M110.130955
  36. Kairys, V.; Gilson, M.K.; Lather, V.; Schiffer, C.A.; Fernandes, M.X.. "Toward the design of mutation-resistant enzyme inhibitors: Further evaluation of the substrate envelope hypothesis". Chemical Biology and Drug Design 74 3 (2009): 234-245. http://www.scopus.com/inward/record.url?eid=2-s2.0-68949201698&partnerID=MN8TOARS.
    10.1111/j.1747-0285.2009.00851.x
  37. de la Torre, J.G.; Cifre, J.G.H.; Ortega, Á.; Schmidt, R.R.; Fernandes, M.X.; Snchez, H.E.P.; Pamies, R.. "Simuflex: Algorithms and tools for simulation of the conformation and dynamics of flexible molecules and nanoparticles in dilute solution". Journal of Chemical Theory and Computation 5 10 (2009): 2606-2618. http://www.scopus.com/inward/record.url?eid=2-s2.0-73949117802&partnerID=MN8TOARS.
    10.1021/ct900269n
  38. Lather, V.; Kairys, V.; Fernandes, M.X.. "Quantitative structure-activity relationship models with receptor-dependent descriptors for predicting peroxisome proliferator-activated receptor activities of thiazolidinedione and oxazolidinedione derivatives". Chemical Biology and Drug Design 73 4 (2009): 428-441. http://www.scopus.com/inward/record.url?eid=2-s2.0-61949250262&partnerID=MN8TOARS.
    10.1111/j.1747-0285.2009.00788.x
  39. Lather, V.; Fernandes, M.X.. "QSAR models for prediction of PPARd agonistic activity of indanylacetic acid derivatives". QSAR and Combinatorial Science 28 4 (2009): 447-457. http://www.scopus.com/inward/record.url?eid=2-s2.0-66149137609&partnerID=MN8TOARS.
    10.1002/qsar.200810092
  40. Cikotiene, I.; Kairys, V.; Buksnaitiene, R.; Morkunas, M.; Rudys, S.; Brukstus, A.; Fernandes, M.X.. "Study on the cyclization of 6-arylethynylpyrimidine-5-carbaldehydes with tert-butylamine: microwave versus thermal preparation of pyrido[4,3-d]pyrimidines". Tetrahedron 65 29-30 (2009): 5752-5759. http://www.scopus.com/inward/record.url?eid=2-s2.0-67149133364&partnerID=MN8TOARS.
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Intellectual property

Provisional application for patent
  1. 2021. "Processes for preparing triazole glycolate oxidase inhibitors".
    Disclosed
  2. 2017. "Compounds for the treatment of diseases caused by oxalate accumulation".
    Disclosed
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2018/10 - Current New chemotherapeutic strategies in cancer to overcome undruggable targets
Co-supervisor
 Ciencias de la Salud (PhD)
Universidad de La Laguna, Spain
2007/09 - 2011/11 Computational and experimental strategies for assessing conformational and dynamic properties of proteins and peptides
Supervisor
 Química (PhD)
Universidade da Madeira, Portugal
2008/09 - 2010/02 Assessment of P-glycoprotein inhibiting compounds
Supervisor
 Bioquímica Aplicada (Master)
Universidade da Madeira, Portugal
2008/09 - 2009/10 Identification of targets in anticancer therapy using molecular modelling techniques
Supervisor
 Bioquímica Aplicada (Master)
Universidade da Madeira, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2017/06 Molecular therapy in primary hyperoxaluria type 1
Thesis Member
 Cristina Martín Higueras (PhD)
Universidad de La Laguna, Spain
2012/12/17 Phenotypic drug discovery. Identification of the mechanism of action of antiproliferative compounds
Thesis Member
 Carla Ríos Lucí (PhD)
Universidad de La Laguna, Spain
2012/05/09 Methodologies for the prediction of conformational and dynamic properties of biological macromolecules in solution
Thesis Member
 Diego Amoros Cerdán (PhD)
Universidad de Murcia, Spain
2011/12 Design Synthesis and Evaluation of Xanthone Derivatives for Dual Activity: Antitumor and P-Glycoprotein Inhibition
(Thesis) Main arguer
 Andreia Filipa dos Santos Palmeira (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal
2011/12 Synthesis of xanthone/benzophenone derivatives by strategy based in molecular targets:potential applications for the treatment of hormone-dependent breast tumors
(Thesis) Arguer
 Elisangela Joaquina Valente da Costa (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal
2005/11 Computational methodologies for solvation properties of rigid and flexible macromolecules
Thesis Member
 Álvaro Ortega Retuerta (PhD)
Universidad de Murcia, Spain

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2012/03 - 2012/07 Modelação Molecular Bioquímica (Licenciatura) Universidade da Madeira, Portugal
2011/03 - 2011/07 Modelação Molecular Bioquímica (Licenciatura) Universidade da Madeira, Portugal
2010/03 - 2010/07 Modelação Molecular Bioquímica (Licenciatura) Universidade da Madeira, Portugal
2009/03 - 2009/07 Modelação Molecular Bioquímica (Licenciatura) Universidade da Madeira, Portugal
2009/03 - 2009/07 Tópicos Avançados em Bioquímica Bioquímica Aplicada (Mestrado) Universidade da Madeira, Portugal
2008/09 - 2009/02 Bioquímica II Bioquímica (Licenciatura) Universidade da Madeira, Portugal
2008/09 - 2009/02 Seminário I Bioquímica Aplicada (Mestrado) Universidade da Madeira, Portugal
2008/03 - 2008/07 Modelação Molecular Bioquímica (Licenciatura) Universidade da Madeira, Portugal
2008/03 - 2008/07 Tópicos Avançados em Bioquímica Bioquímica Aplicada (Mestrado) Universidade da Madeira, Portugal
2007/09 - 2008/02 Bioquímica II Bioquímica (Licenciatura) Universidade da Madeira, Portugal
2007/09 - 2008/02 Química Física III Química (Licenciatura) Universidade da Madeira, Portugal
2007/09 - 2008/02 Seminário I Bioquímica Aplicada (Mestrado) Universidade da Madeira, Portugal
2007/03 - 2007/07 Espectroscopia Molecular Química (Licenciatura) Universidade da Madeira, Portugal
2007/03 - 2007/07 Métodos Computacionais em Química Química (Licenciatura) Universidade da Madeira, Portugal
2006/09 - 2007/02 Bioquímica III Bioquímica (Licenciatura) Universidade da Madeira, Portugal
2006/09 - 2007/02 Química Física III Química (Licenciatura) Universidade da Madeira, Portugal
2006/03 - 2006/07 Métodos Computacionais em Química Química (Licenciatura) Universidade da Madeira, Portugal
2006/03 - 2006/07 Ética e Documentação Química (Licenciatura) Universidade da Madeira, Portugal
2005/09 - 2006/02 Fundamentos de Química I Bioquímica (Licenciatura) Universidade da Madeira, Portugal
2005/09 - 2006/02 Química Física III Química (Licenciatura) Universidade da Madeira, Portugal
2005/09 - 2006/02 Bioquímica Geral Química (Licenciatura) Universidade da Madeira, Portugal
2005/03 - 2005/07 Fundamentos de Química II Química (Licenciatura) Universidade da Madeira, Portugal
2005/03 - 2005/07 Métodos Computacionais em Química Química (Licenciatura) Universidade da Madeira, Portugal
2004/09 - 2005/02 Fundamentos de Química I Bioquímica (Licenciatura) Universidade da Madeira, Portugal
2004/09 - 2005/02 Química-Física III Química (Licenciatura) Universidade da Madeira, Portugal

Other jury / evaluation

Activity description Institution / Organization
2021/09 - Current Comissão de Acompanhamento de Tese do aluno José João Serina Título da tese: Caffeoylquinic acids from metabolic regulators to bio-pesticides, in silico and in vitro studies Doutoramento: Química Universidade da Madeira, Portugal
2019/09 - Current Comissão de Acompanhamento de Tese de da aluna Isabel Betancor Fernández Título da tese: Gene expression profiles in breast cancer and their relationship with clinicopathological variables Doutoramento: Ciencias de la Salud Universidad de La Laguna, Spain
2019/09 - Current Comissão de Acompanhamento de Tese da aluna Laura Karina de Freitas Tacoronte Título da tese: Implementation of high-throughput cancer genotyping in resource-limited environments Universidad de La Laguna, Spain
2019/09 - 2021/06 Comissão de Acompanhamento de Tese da aluna Patricia García García Título da tese: Estrategias para regeneración ósea en osteoporosis: estructuras 3D y liberación controlada Doutoramento: Ciencias de la Salud Universidad de La Laguna, Spain
2017/07 - 2020/07 Comissão de Acompanhamento de Tese do aluno Héctor Martín Estévez Silva Título da tese: The therapeutic potencial of sigma-1 proteins as a treatment for cognitive disorders related to aging and neurodegenerative diseases Doutoramento: Ciencias de la Salud Universidad de La Laguna, Spain