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L. Côrte-Real obtained her degree in Technological Chemistry (2010) from Faculdade de Ciências, Universidade de Lisboa (FCUL), where she also completed a master's degree in Biomedical Inorganic Chemistry: Applications in Diagnosis and Therapy (2012). During her master's project, she had the opportunity to work at Campus Tecnológico e Nuclear (C2TN) and Instituto de Medicina Molecular (IMM), studying the mechanisms of action of promising organometallic Ru compounds for cancer therapy, which gave her all the necessary tools to become independent in several biological assays (e.g. cell viability assays - MTT; evaluation of the cell death mechanism and cell cycle arrest - Flow cytometry), that are now an important complement of her scientific path. In June 2019, she obtained her Ph.D. in Chemistry (specialization in Inorganic Chemistry - Full score) from Universidade de Lisboa, where she developed polymer-metal based compounds for cancer targeted therapy. During her Ph.D., she was awarded a Fulbright grant to study her metallodrugs in the zebrafish model at Rutgers University, New Jersey, USA (February 2018 - July 2018: 6 months), further expanding her expertise panel. After her Ph.D., she was a Junior Researcher at Centro de Química Estrutural (CQE), FCUL, in the scope of the Project Lead4Target - PTDC/QUI-QIN/28662/2017 (PI: Dr. Andreia Valente) working on the synthesis, characterization and determination of the biological activity of metal-based compounds with potential as anticancer drugs and on ligand functionalization with relevant biomolecules for cancer targeted therapy. She also focused on the preparation and characterization (by Dynamic Light Scattering) of compounds' nanoformulations using drug-delivery systems for cancer therapy. In August 2021, she won a Postdoctoral fellowship at CQE@Instituto Superior Técnico (IST), working on novel nanoplatforms for targeting melanoma with 8-hydroxyquinoline metal complexes (Project: PTDC/QUI-QIN/0586/2020; PI: Prof. I. Correia). L. Côrte-Real has supervised so far 10 undergraduate students (3 Erasmus students, 1 Summer Internship student, 1 IASTE Program student) and will supervise 3 MSc students (1 ongoing; for 9 months). She has 24 scientific papers published in international peer-reviewed journals (9 as first author), with over 500 citations; 34 oral communications: 5 by invitation; 9 as invited co-author; 8 as speaker and 12 as co-author, and an h-index of 13 (Scopus). She was recently awarded an FCT-RESTART grant to start her independent research career, working on Cu(I)-NHC coumarin-based conjugates for treating aggressive cancers via folate-targeted approach.
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Identification

Personal identification

Full name
Leonor de Sá Nogueira Corte-real
Date of birth
1987/07/27
Gender
Female

Citation names

  • Côrte-Real, Leonor

Author identifiers

Ciência ID
F112-59D7-0984
ORCID iD
0000-0002-4974-1075
Google Scholar ID
vnK983YAAAAJ
Researcher Id
H-5636-2013
Scopus Author Id
55627880500

Email addresses

  • leonor.corte-real@tecnico.ulisboa.pt (Professional)

Telephones

Telephone
  • 218419270 Ext.: 3318 (Professional)

Addresses

  • Centro de Química Estrutural, Institute of Molecular Sciences, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais 1, 1049-001, Lisboa, Lisboa, Portugal (Professional)

Websites

Knowledge fields

  • Exact Sciences - Chemical Sciences - Inorganic Chemistry
  • Exact Sciences - Chemical Sciences - Organic Chemistry
  • Natural sciences - Biological Sciences - Biochemical Research Methods
  • Natural sciences - Biological Sciences - Biochemistry
  • Medical and Health Sciences - Basic Medicine - Medicinal Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Elementary (A2) Elementary (A2) Elementary (A2) Elementary (A2)
French Elementary (A2) Elementary (A2) Elementary (A2) Elementary (A2)
Education
Degree Classification
2021
Concluded
 Post-Graduate Course on Science Update in Laboratory Animals (Pós-Graduação)
Universidade de Lisboa Faculdade de Farmácia, Portugal
 17
2015 - 2019/06
Concluded
 Chemistry (Doutoramento)
Major in Inorganic Chemistry
Universidade de Lisboa Faculdade de Ciências, Portugal
"Polymer-metal based compounds to target (non)hormone-responsive cancers: synthesis and mechanistic evaluation" (THESIS/DISSERTATION)
 Approved by unanimity with Distinction and Honors (Summa cun laude)
2010 - 2012
Concluded
 Biomedical Inorganic Chemistry: Applications in Diagnosis and Therapy (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Complexos de Ruténio como potenciais agentes terapêuticos: estudos dos mecanismos de captação celular e modulação de enzimas metabólicos" (THESIS/DISSERTATION)
2007 - 2010
Concluded
 Technological Chemistry (Licenciatura)
Major in Materials and Environment
Universidade de Lisboa Faculdade de Ciências, Portugal
"Estudos de adsorção selectiva de vapores em titanossilicatos microporosos" (THESIS/DISSERTATION)
Affiliation

Science

Category
Host institution 		Employer
2024/04/08 - Current Researcher (Research) Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
Universidade de Lisboa Centro de Química Estrutural, Portugal
2021/08/01 - 2024/04/07 Postdoc (Research) Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
Universidade de Lisboa Centro de Química Estrutural, Portugal
2019/07 - 2021/07 Contracted Researcher (Research) Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
Universidade de Lisboa Faculdade de Ciências, Portugal

Others

Category
Host institution 		Employer
2015 - 2019 PhD Student at CQE, FCUL Universidade de Lisboa Faculdade de Ciências, Portugal
Universidade de Lisboa Faculdade de Ciências, Portugal
2018/02/02 - 2018/07/31 Visiting Researcher at Rutgers University (U.S.A.) in the framework of the PhD Thesis Universidade de Lisboa Faculdade de Ciências, Portugal
Rutgers The State University of New Jersey, United States
2016/04/03 - 2016/04/16 Visiting Researcher at Universidad de Oviedo, Oviedo (Spain) in the framework of the PhD Thesis Universidade de Lisboa Faculdade de Ciências, Portugal
Universidad de Oviedo, Spain
2014 - 2014 Research Fellow under the project PEst-OE/QUI/UI0100/2013 Universidade de Lisboa Instituto Superior Técnico, Portugal
Universidade de Lisboa Instituto Superior Técnico, Portugal
2013 - 2013 Research Fellow under the project "Ruthenium complexes for anti-tumour application" (PTDC/QuiQui/101187/2008) Universidade de Lisboa Faculdade de Ciências, Portugal
Universidade de Lisboa Faculdade de Ciências, Portugal
2011 - 2012 Researcher at Campus Tecnológico e Nuclear (C2TN) in the framework of the MSc. Thesis Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
Centro de Ciências e Tecnologias Nucleares, Portugal
2011 - 2012 Researcher at Instituto de Medicina Molecular (IMM) in the framework of the MSc. Thesis Universidade de Lisboa Faculdade de Medicina, Portugal
Instituto de Medicina Molecular, Portugal
Projects

Grant

Designation Funders
2023/12/23 - Current Unlocking the potential of Cu(I)-NHC coumarin-based conjugates for the treatment of aggressive cancers via folate-targeted approach
2023.00031.RESTART
Principal investigator
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2021/08/01 - 2024/04/07 PTDC/QUI-QIN/0586/2020, Novel Nanoplatforms for targeting melanoma with 8-hydroxyquinoline metal complexes
PTDC/QUI-QIN/0586/2020
Post-doc Fellow
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2013 - 2014 PROJECTO ESTRATÉGICO - UI 100 - 2013-2014 (PEst-OE/QUI/UI0100/2013)
PEst-OE/QUI/UI0100/2013
Researcher
Universidade de Lisboa Faculdade de Ciências, Portugal

Contract

Designation Funders
2019/07 - 2021/07 PTDC/QUI-QIN/28662/2017, Lead4Target - Fighting metastatic cancers: prime time for ruthenium
PTDC/QUI-QIN/28662/2017
Researcher
Universidade de Lisboa Faculdade de Ciências, Portugal
Concluded
2019/01/01 - 2019/12/31 Centro de Química Estrutural
UID/QUI/00100/2019
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Lisboa Centro de Química Estrutural, Portugal
Fundação para a Ciência e a Tecnologia
Concluded

Other

Designation Funders
2013/01/01 - 2013 PTDC/QuiQui/101187/2008 - Ruthenium complexes for anti-tumour application
info:eu-repo/grantAgreement/FCT/3599-PPCDT/101187/PT
Researcher
Universidade de Lisboa Faculdade de Ciências, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference paper
  1. De Matos, A.P.A.; Marques, F.M.; Côrte-Real, L.; Garcia, M.H.. "Ultrastructural Studies of the Cellular Effects of Antitumoral Compounds". Paper presented in INCOMAM'14, International Conference on Microscopy and Microanalysis, XLVIII Congress of the Portuguese Microscopy Society, 2014.
    Published • 10.1017/S1431927615014099
Conference poster
  1. H. Kovács; Côrte-Real, Leonor; I. Correia; G. Spengler; É.A. Enyedy. Corresponding author: H. Kovács. "Solution equilibrium studies on 8-hydroxyquinoline reduced Schiff bases and their complexes with essential metal ions". Paper presented in 4th European NECTAR Conference and Final Action Meeting, 2024.
  2. T. Jakusch; V. Józó; I. Szatmári; S. Tóth; G. Szakács; Côrte-Real, Leonor; I. Correia; É. A. Enyedy. Corresponding author: É. A. Enyedy. "Complex formation of anticancer 8-hydroxyquinoline derivatives with oxidovanadium(IV): solution stability and structure". Paper presented in 13th International Vanadium Symposium, 2023.
  3. Pedro Adão; Calado, Maria da Luz; Luís Alves; Côrte-Real, Leonor; Mafalda Guedes; Ricardo Baptista; Raul Bernardino; et al. Corresponding author: Pedro Adão. "Development of algal polysaccharide films hardened with processed stone sludge". Paper presented in Global Stone Congress (Batalha, Portugal), 2023.
  4. Teixeira, R.G.; Côrte-Real, Leonor; J. Mészáros; X. Fontrodona; I. Romero; G. Spengler; M.H. Garcia; et al. Corresponding author: Teixeira, R.G.. "Exploring the effect of phosphane functionalization on RuCp complexes: from synthesis to biological evaluation". Paper presented in CQE Days 2023 (Academia de Ciências de Lisboa, Portugal), 2023.
  5. J. Lopes; C.P. Matos; M. Albino; Côrte-Real, Leonor; J. Costa Pessoa; I. Correia; C.P. Reis; M. Manuela Gaspar. Corresponding author: M. Manuela Gaspar. "Liposomal formulations of new iron(III) anti-cancer complexes as a potential strategy for melanoma management". Paper presented in 7th International Symposium on Phospholipids in Pharmaceutical Research (Heidelberg, Germany), 2022.
  6. Pedro Adão e Silva; Calado, Maria da Luz; Côrte-Real, Leonor; Raul Bernardino; Susana Bernardino; Maria Jorge Campos; Maria M. Gil. Corresponding author: Pedro Adão e Silva. "Application of stone cutting sludge in the preparation of alginate films with potential antimicrobial activity". Paper presented in EuChemS (Lisbon, Portugal), 2022.
  7. Vivien Pósa; Côrte-Real, Leonor; Isabel Romero; Figueira, Mariana; Reis, Catarina Pinto; Gaspar, Maria Manuela; Pessoa, João Costa; Correia, Isabel; Éva Enyedy. Corresponding author: Vivien Pósa. "Solution studies on the interaction of three new Schiff base 8-hydroxyquinolines with essential metal ions". Paper presented in 3rd European Nectar Conference (Ljubljana, Slovenia), 2022.
  8. P.F. Farinha; Côrte-Real, Leonor; N. Ribeiro; J.O. Pinho; H. Luíz; C.P. Reis; J.D. Amaral; et al. Corresponding author: M.M. Gaspar. "Metal-based complexes with high potential towards colon cancer". Paper presented in 13th iMed.ULisboa Postgraduate Students Meeting (Faculdade de Farmácia Universidade de Lisboa, Portugal), 2022.
  9. Andreia Valente; Tânia S. Morais; Leonor Côrte-Real; Ana Isabel Tomaz; M. José Brito; M. Helena Garcia. "Metallodrugs for Cancer Therapy: Challenges and Expectations". Paper presented in CIÊNCIAS Research Day 2020, Online Zoom Sessions, 2020.
  10. Adhan Pilon; Ana Rita Brás; Leonor Côrte-Real; Fernando Avecilla; Paulo J. Costa; Ana Preto; M. Helena Garcia; Andreia Valente. "A New family of Iron-Cyclopentadienyl compounds: Synthesis and Biological Evaluation". Paper presented in CQE Days, Spring Meeting, Online twitter and Zoom Sessions, 2020.
  11. Andreia Valente; Tânia S. Morais; Leonor Côrte-Real; Ana Isabel Tomaz; M. José Brito; M. Helena Garcia. "Metallodrugs for Cancer Therapy: Challenges and Expectations". Paper presented in CIÊNCIAS Research Day 2019 (Lisboa, Portugal), 2019.
  12. Leonor Côrte-Real; Patrícia Gírio; Alexis Moreno; M. Helena Garcia; Pierre Falson; Andreia Valente. "Novel ruthenium-cyclopentadienyl complexes as potential candidates to surmount multidrug resistance in cancer". Paper presented in UL Chemistry PhD Meeting (2ECQUL, Lisbon, Portugal), 2017.
  13. Ricardo Teixeira; Leonor Côrte-Real; Fernando Avecilla; M. Helena Garcia; Fernanda Marques; Andreia Valente. "New ruthenium-methylcyclopentadienyl family of anticancer agents: synthesis, characterization and in vitro studies". Paper presented in Chem&BioChem Postgraduate Students Meeting (Lisbon, Portugal), 2017.
  14. Fernanda Marques; Leonor Côrte-Real; Tânia S. Morais; M. Helena Garcia; António P. Matos; Lurdes Gano; Manuel Bicho. "Ruthenium-based anticancer compounds: Insights into their uptake mechanisms and cellular targets". Paper presented in 4th World Congress on Cancer Science & Therapy (Chicago, USA), 2014.
  15. F. Marques; Côrte-Real, Leonor; T.S. Morais; M.H. Garcia; A.P. Matos; L. Gano; M. Bicho. Corresponding author: F. Marques. "Ruthenium-based anticancer compounds: Insights into their uptake mechanisms and cellular targets". Paper presented in 4th World Congress on Cancer Science & Therapy (Chicago, USA), 2014.
  16. Fernanda Marques; António P. Matos; Leonor Côrte-Real; Tânia S. Morais; M. Helena Garcia. "Novel Pathways for Anticancer Therapy: the role of golgi network in the mechanism of cell death of organometallic Ru complexes". Paper presented in Microscopy in Research,. Egas Moniz - Cooperativa de Ensino (Almada, Portugal), 2013.
Journal article
  1. Pedro Adão; Maria da Luz Calado; Wilson Fernandes; Luís G. Alves; Leonor Côrte-Real; Mafalda Guedes; Ricardo Baptista; et al. "Use of Limestone Sludge in the Preparation of Carrageenan/Alginate-Based Films". Materials 17 (2024): https://doi.org/10.3390/ma17071668.
    Published • 10.3390/ma17071668
  2. Leonor Côrte-Real; Baris Sergi; Busra Yildirim; Raquel Colucas; Radoslaw Starosta; Xavier Fontrodona; Isabel Romero; et al. "Enhanced selectivity towards melanoma cells with zinc(ii)-Schiff bases containing imidazole derivatives". Dalton Transactions (2024): https://doi.org/10.1039/D4DT00733F.
    Published • 10.1039/D4DT00733F
  3. Côrte-Real, Leonor; V. Pósa; M. Martins; R. Colucas; N.V. May; X. Fontrodona; I. Romero; et al. Corresponding author: I. Correia. "Cu(II) and Zn(II) complexes of new 8-hydroxyquinoline Schiff bases: Investigating their structure, solution speciation and anticancer potential". Inorganic Chemistry 62 29 (2023): 11466-11486. https://pubs.acs.org/doi/full/10.1021/acs.inorgchem.3c01066.
    Published
  4. R.G. Teixeira; J.P. Mészáros; B. Matos; Côrte-Real, Leonor; C.P.R. Xavier; X. Fontrodona; M.H. Garcia; et al. Corresponding author: A. Valente. "Novel family of [RuCp(N,N)(P)]+ compounds with simultaneous anticancer and antibacterial activity: Biological evaluation and solution chemistry studies". European Journal of Medicinal Chemistry 262 (2023): 115922. https://publons.com/wos-op/publon/64113463/.
    Published • 10.1016/J.EJMECH.2023.115922
  5. Matos, Cristina P.; Albino, Melissa; Lopes, Joana; Viana, Ana Silveira; Côrte-Real, Leonor; Mendes, Filipa; Pessoa, João Costa; et al. "New iron(III) anti-cancer aminobisphenolate/phenanthroline complexes: Enhancing their therapeutic potential using nanoliposomes". International Journal of Pharmaceutics 623 (2022): 121925. http://dx.doi.org/10.1016/j.ijpharm.2022.121925.
    Published • 10.1016/j.ijpharm.2022.121925
  6. Leonor Côrte-Real; Ana Rita Brás; Adhan Pilon; Nuno Mendes; Ana Sofia Ribeiro; Tiago D. Martins; José Paulo S. Farinha; et al. "Biotinylated Polymer-Ruthenium Conjugates: In Vitro and In Vivo Studies in a Triple-Negative Breast Cancer Model". Pharmaceutics 14 7 (2022): 1388-1388. https://doi.org/10.3390/pharmaceutics14071388.
    Published • 10.3390/pharmaceutics14071388
  7. Karas, Brittany F.; Doherty, Cathleen L.; Terez, Kristin R.; Côrte-Real, Leonor; Cooper, Keith R.; Buckley, Brian T.. "Dose Uptake of Platinum- and Ruthenium-based Compound Exposure in Zebrafish by Inductively Coupled Plasma Mass Spectrometry with Broader Applications". Journal of Visualized Experiments 182 (2022): https://www.jove.com/t/63587/dose-uptake-platinum-ruthenium-based-compound-exposure-zebrafish.
    Published
  8. Karas, Brittany F; Hotz, Jordan M; Gural, Brian M; Terez, Kristin R; DiBona, Victoria L; Côrte-Real, Leonor; Valente, Andreia; Buckley, Brian T; Cooper, Keith R. "Anti-cancer activity and in vitro to in vivo mechanistic recapitulation of novel ruthenium-based metallodrugs in the zebrafish model". Toxicological Sciences (2021): http://dx.doi.org/10.1093/toxsci/kfab041.
    Published • 10.1093/toxsci/kfab041
  9. Amiri Rudbari, Hadi; Kordestani, Nazanin; Correia, Isabel; Valente, Andreia; Côrte-Real, Leonor; Islam, Mohammad Khairul; Micale, Nicola; et al. "Heteroleptic enantiopure Pd(II)-complexes derived from halogen-substituted Schiff bases and 2-picolylamine: synthesis, experimental and computational characterization and investigation of the in¿uence of chirality and halogen atoms on the anticancer activity". New Journal of Chemistry (2021): http://dx.doi.org/10.1039/d1nj01491a.
    Published • 10.1039/d1nj01491a
  10. Pilon, A.; Brás, A.R.; Côrte-Real, L.; Avecilla, F.; Costa, P.J.; Preto, A.; Garcia, M.H.; Valente, A.. "A New Family of Iron(II)-Cyclopentadienyl Compounds Shows Strong Activity against Colorectal and Triple Negative Breast Cancer Cells". Molecules 25 7 (2020): 1592. http://dx.doi.org/10.3390/molecules25071592.
    Published • 10.3390/molecules25071592
  11. Côrte-Real, L.; Karas, B.; Brás, A.R; Pilon, A.; Avecilla, F.; Marques, F.; Preto, A.; et al. "Ruthenium-Cyclopentadienyl Bipyridine-Biotin Based Compounds: Synthesis and Biological Effect". Inorganic Chemistry 58 14 (2019): 9135-9149. http://dx.doi.org/10.1021/acs.inorgchem.9b00735.
    Published • 10.1021/acs.inorgchem.9b00735
  12. Karas, B.F.; Côrte-Real, L.; Doherty, C.L.; Valente, A.; Cooper, K.R.; Buckley, B.T.. "A novel screening method for transition metal-based anticancer compounds using zebrafish embryo-larval assay and inductively coupled plasma-mass spectrometry analysis". Journal of Applied Toxicology 39 8 (2019): 1173-1180. http://dx.doi.org/10.1002/jat.3802.
    Published • 10.1002/jat.3802
  13. Côrte-Real, L.; Karas, B.; Gírio, P.; Moreno, A.; Avecilla, F.; Marques, F.; Buckley, B.T.; et al. "Unprecedented inhibition of P-gp activity by a novel ruthenium-cyclopentadienyl compound bearing a bipyridine-biotin ligand". European Journal of Medicinal Chemistry 163 (2019): 853-863. http://dx.doi.org/10.1016/j.ejmech.2018.12.022.
    Published • 10.1016/j.ejmech.2018.12.022
  14. Teixeira, R.G.; Brás, A.R.; Côrte-Real, L.; Tatikonda, R.; Sanches, A.; Robalo, M.P.; Avecilla, F.; et al. "Novel ruthenium methylcyclopentadienyl complex bearing a bipyridine perfluorinated ligand shows strong activity towards colorectal cancer cells". European Journal of Medicinal Chemistry 143 (2018): 503-514. http://www.scopus.com/inward/record.url?eid=2-s2.0-85036521878&partnerID=MN8TOARS.
    Published • 10.1016/j.ejmech.2017.11.059
  15. Côrte-Real, L.; Teixeira, R.G.; Gírio, P.; Comsa, E.; Moreno, A.; Nasr, R.; Baubichon-Cortay, H.; et al. "Methyl-cyclopentadienyl Ruthenium Compounds with 2,2'-Bipyridine Derivatives Display Strong Anticancer Activity and Multidrug Resistance Potential". Inorganic Chemistry 57 8 (2018): 4629-4639. http://www.scopus.com/inward/record.url?eid=2-s2.0-85045544510&partnerID=MN8TOARS.
    Published • 10.1021/acs.inorgchem.8b00358
  16. Dömötör, O.; de Almeida, R.F.M.; Côrte-Real, L.; Matos, C.P.; Marques, F.; Matos, A.; Real, C.; et al. "Studies on the mechanism of action of antitumor bis(aminophenolate) ruthenium(III) complexes". Journal of Inorganic Biochemistry 168 (2017): 27-37. https://doi.org/10.1016%2Fj.jinorgbio.2016.12.008.
    Published • 10.1016/j.jinorgbio.2016.12.008
  17. Côrte-Real, L.; Robalo, M.P.; Marques, F.; Nogueira, G.; Avecilla, F.; Silva, T.J.L.; Santos, F.C.; et al. "The key role of coligands in novel ruthenium(II)-cyclopentadienyl bipyridine derivatives: Ranging from non-cytotoxic to highly cytotoxic compounds". Journal of Inorganic Biochemistry 150 (2015): 148-159. http://dx.doi.org/10.1016/j.jinorgbio.2015.06.015.
    Published • 10.1016/j.jinorgbio.2015.06.015
  18. Côrte-Real, L.; Mendes, F.; Coimbra, J.; Morais, T.S; Tomaz, A.I.; Valente, A.; Garcia, M.H.; et al. "Anticancer activity of structurally related ruthenium(II) cyclopentadienyl complexes". Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 19 6 (2014): 853-67. https://link.springer.com/article/10.1007/s00775-014-1120-y.
    Published • 10.1007/s00775-014-1120-y
  19. Valente, A.; Santos, A.M.; Côrte-Real, L.; Robalo, M.P.; Moreno, V.; Font-Bardia, M.; Calvet, T.; Lorenzo, J.; Garcia, M.H.. "New iron(II) cyclopentadienyl derivative complexes: Synthesis and antitumor activity against human leukemia cancer cells". Journal of Organometallic Chemistry 756 (2014): 52-60. https://www.sciencedirect.com/science/article/pii/S0022328X14000424.
    Published • 10.1016/j.jorganchem.2014.01.027
  20. Morais, T.S.; Santos, F.C.; Jorge, T.F.; Côrte-Real, L.; Madeira, P.J.A.; Marques, F.; Robalo, M.P.; et al. "New water-soluble ruthenium(II) cytotoxic complex: Biological activity and cellular distribution". Journal of Inorganic Biochemistry 130 (2014): 1-14. https://www.sciencedirect.com/science/article/pii/S0162013413002468?via%3Dihub.
    Published • 10.1016/j.jinorgbio.2013.09.013
  21. Marques, F.; Côrte-Real, L.; Alves de Matos, A.P.; Alho, I.; Morais, T.S.; Tomaz, A.I.; Garcia, M.H.; Bicho, M.P.. "Intracellular distribution of antitumor Ru (II) compounds: The lysosome and the lysosomal enzymes as targets for anticancer metal-based drugs". Microscopy and Microanalysis 19 (2013): 9-10. https://www.cambridge.org/core/journals/microscopy-and-microanalysis/article/intracellular-distribution-of-antitumor-ru-ii-compounds-the-lysosome-and-the-lysosomal-enzymes-as-targets-for-anticancer-metalbased-drugs/0CD089898822437A0E274F08071A2BFF.
    Published • 10.1017/S1431927613000664
  22. Morais, T.S.; Santos, F.C.; Côrte-Real, L.; Garcia, M.H.. "Exploring the effect of the ligand design on the interactions between [Ru(eta5-C5H5)(PPh3)(N,O)][CF3SO3] complexes and Human Serum Albumin". Journal of Inorganic Biochemistry 129 (2013): 94-101. https://www.sciencedirect.com/science/article/pii/S0162013413002419?via%3Dihub.
    Published • 10.1016/j.jinorgbio.2013.09.008
  23. Morais, T.S.; Santos, F.; Côrte-Real, L.; Marques, F.; Robalo, M.P.; Madeira, P.J.A.; Garcia, M.H.. "Biological activity and cellular uptake of [Ru(eta5-C5H5)(PPh3)(Me2bpy)][CF3SO3] complex". Journal of Inorganic Biochemistry 122 (2013): 8-17. https://www.sciencedirect.com/science/article/pii/S0162013413000263?via%3Dihub.
    Published • 10.1016/j.jinorgbio.2013.01.011
  24. Côrte-Real, L.; Matos, A.P.; Alho, I.; Morais, T.S.; Tomaz, A.I.; Garcia, M.H.; Santos, I.; Bicho, M.P.; Marques, F.. "Cellular Uptake Mechanisms of an Antitumor Ruthenium Compound: The Endosomal/Lysosomal System as a Target for Anticancer Metal-Based Drugs". Microscopy and Microanalysis 19 5 (2013): 1122-1130. https://www.cambridge.org/core/journals/microscopy-and-microanalysis/article/abs/cellular-uptake-mechanisms-of-an-antitumor-ruthenium-compound-the-endosomallysosomal-system-as-a-target-for-anticancer-metalbased-drugs/40E8B84D9DDE0CA3B5074B74CFAAD6D3.
    Published • 10.1017/S143192761300175X
Magazine article
  1. Côrte-Real, L.. "Combate ao Cancro da Mama Invasivo com Fármacos de Ruténio", Boletim Química SPQ, 2020, https://www.spq.pt/magazines/BSPQuimica/694/article/30002332/pdf.
Thesis / Dissertation
  1. Côrte-Real, Leonor. "Polymer-metal based compounds to target (non)hormone-responsive cancers: synthesis and mechanistic evaluation". PhD, Universidade de Lisboa Faculdade de Ciências, 2019.
  2. Côrte-Real, Leonor de Sá Nogueira. "Complexos de ruténio como potenciais agentes terapêuticos: estudos dos mecanismos de captação celular e modulação de enzimas metabólicas". Master, 2012. http://hdl.handle.net/10451/9690.
  3. Côrte-Real, Leonor. "Estudos de adsorção selectiva de vapores em titanossilicatos microporosos". Degree, Universidade de Lisboa Faculdade de Ciências, 2010.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/11 |Invited co-author| "Metal complexes of 8-hydroxyquinoline derived ligands with anticancer potential", I. Correia*, Leonor Côrte-Real, Nádia Ribeiro, Éva Enyedy, Xavier Fontrodona, Isabel Romero (To be held online in December) 9th Latin American Symposium on Coordination and Organometallic Chemistry (SiLQCOM)
(Havana, Cuba)
2024/08 |Invited co-author| "Metallodrugs based on 8-hydroxyquinoline Schiff bases: structure, reactivity and anticancer potential", I. Correia*, L. Côrte-Real, E. Enyedy, C, Acilan, M. Gaspar, C. Reis. 45th International Conference on Coordination Chemistry (ICCC 2024)
(Fort Collins, United States)
2024/05 |Invited Speaker| "The anticancer potential of 8-hydroxyquinoline Schiff base metal complexes containing N-heterocycles", L. Côrte-Real*, B. Sergi, B. Yildirim, R. Starosta, M. Coelho, I. Neto, J. Lopes, C.P. Reis, M.M. Gaspar, C. Acylan, I. Correia 14th Inorganic & Bioinorganic Chemistry Conference
Rectorate of NOVA University of Lisbon (Lisboa, Portugal)
2024/03/06 "Synthesis of Zinc(II) Schiff base complexes as promising anti-cancer agents". R. Chamaillard*, Leonor Côrte-Real& &PI and Supervisor Workshop: Breakthroughs of non-platinum anticancer metallopharmaceuticals
Instituto Superior Técnico, Lisboa (Lisboa, Portugal)
2024/03 |Invited Speaker| "Mastering selectivity: the newest challenge in cancer drug design", L. Côrte-Real Workshop: Breakthroughs of non-platinum anticancer metallopharmaceuticals
Instituto Superior Técnico, ULisboa (Lisboa, Portugal)
2023/11/22 |Speaker| "Oxidovanadium(IV) complexes containing 8-hydroxyquinoline Schiff bases – synthesis, characterization and biological screening". L. Côrte-Real*, A. Alborghetti, I. Neto, M. Coelho, J. Lopes, M.M. Gaspar, C. Pinto Reis, X. Fontrodona, I. Romero, I. Correia 13th International Vanadium Symposium
(Portugal)
2023/06/11 "8-Hydroxyquinoline metal complexes: structure, reactivity and anticancer potential". I. Correia*, L. Côrte-Real, N. Ribeiro, V. Pósa, E.A. Enyedy, X. Fontrodona, I. Romero, J. Costa Pessoa, B. Sergi, I. Bulut, C. Acilan, C.P. Reis, M.M. Gaspar 16th International Symposium on Applied Bioinorganic Chemistry (ISABC)
(Ionnina, Greece)
2023/05/25 |Speaker| "Exploring the anticancer potential of novel Cu(II) and Zn(II) complexes of 8-hydroxyquinoline Schiff bases". L. Côrte-Real*, V. Pósa, E. Enyedy, X. Fontrodona, I. Romero, F. Mendes, C. Pinto Reis, M.M. Gaspar, J. Costa Pessoa, I. Correia CQE Days 2023
(Lisbon, Portugal)
2023/04/25 |Invited co-author| "Metal complexes of 8-hydroxyquinoline Schiff bases: Structure, speciation and anticancer screening". L. Côrte-Real, M. Martins, R. Colucas, V. Pósa, E. Enyedy, X. Fontrodona, I. Romero, F. Mendes, J. Costa Pessoa, I. Correia* VIII Latin American Meeting on Biological Inorganic Chemistry
(Vinã del Mar, Chile)
2022/06/05 |Speaker| "New Zn(II) and Cu(II) Schiff base metal complexes based on 8- hydroxyquinoline scaffold designed for efficient cancer therapy". L. Côrte-Real*, I. Romero, M. Figueira, C. Pinto Reis, M.M. Gaspar, J. Costa Pessoa, I. Correia International Symposium on Metal Complexes (ISMEC)
(Valência, Spain)
2020/02/27 "Ruthenium-cyclopentadienyl bipyridine-biotin based compound: P-gp inhibition and activity against resistant cancer cells". Andreia Valente*, Leonor Côrte-Real, M. Helena Garcia, Marie Ehrlichova, Radka Vaclavikova STRATAGEM CA17104 Annual Conference, 3rd meeting and 4th WGs meeting
(Belgrade, Serbia)
2020/01 |Speaker| "Fighting Breast Cancer with Ruthenium-based Metallodrugs endowed with Tumor-targeting Vectors". Leonor Côrte-Real*, Ana Rita Brás, Ana Preto, M. Helena Garcia, Andreia Valente 13º Encontro Nacional de Química Orgânica/6º Encontro Nacional de Química Terapêutica, 15th-17th January 2020
Universidade de Aveiro (Aveiro, Portugal)
2019/12/02 |Invited co-author| "Strategies for targeted cancer therapy using ruthenium-cyclopentadienyl complexes". Andreia Valente*, Leonor Côrte-Real, Ana Rita Brás, M. Helena Garcia, Ana Preto 3rd International Caparica Christmas Congress on Translational Chemistry
(Caparica, Portugal)
2019/09 |Invited Speaker| "New ruthenium-cyclopentadienyl complexes bearing biotinylated (macro)ligands: Targeting strategies to fight metastatic breast cancer". Leonor Côrte-Real*, Ana Rita Brás, Ana Preto, M. Helena Garcia, Andreia Valente 6th Young Medicinal Chemist Symposium (EFMC-YMCS 2019), 5-6 September 2019
(Athens, Greece)
2019/06/24 "Targeting cancer with selective and potent ruthenium compounds". Andreia Valente*, Leonor Côrte-Real, M. Helena Garcia 6th World Congress on Natural Product & Synthetic Chemistry & 3rd Annual Cell Congress
(New York, United States)
2018/08 "Novel ruthenium methylcyclopentadienyl complexes bearing bipyridine based ligands with strong anticancer activity". M. Helena Garcia,* Ricardo G. Teixeira, Leonor Côrte-Real, Patrícia Gírio, Andreia Valente International Conference on Coordination Chemistry
(Sendai, Japan)
2018/07 "Ruthenium Cyclopentadienyl Compounds: Cytotoxic Agents Against Resistant Cancer Cells". Andreia Valente*, Leonor Côrte-Real, M. Helena Garcia 12th Inorganic and Bioinorganic Chemistry Conference
(Porto, Portugal)
2018/03 "Novel ruthenium cyclopentadienyl complexes bearing bipyridine based (macro)ligands with strong activity towards cancer cells". Ricardo G. Teixeira, Ana Rita Brás, Leonor Côrte-Real, Rajendhraprasad Tatikonda, M. Helena Garcia, Matti Haukka, Ana Preto, Andreia Valente* 4th European Conference on Smart Inorganic Polymers
(Zagreb, Croatia)
2017/12 |Invited co-author| "ABC proteins: targets for ruthenium-cyclopentadienyl anticancer compounds?". Andreia Valente*, Patrícia Gírio, Leonor-Côrte-Real, Ricardo Teixeira, Pierre Falson, M. Helena Garcia II International Caparica Christmas Congress on Translational Chemistry
(Caparica, Portugal)
2017/12 |Speaker| "Novel ruthenium-cyclopentadienyl complexes as potential candidates to surmount multidrug resistance in cancer". Leonor Côrte-Real*, Patrícia Gírio, Alexis Moreno, M. Helena Garcia, Pierre Falson, Andreia Valente UL Chemistry PhD Meeting (2ECQUL)
(Lisboa, Portugal)
2017/08 |Invited co-author| "Unprecedented polymer-metal vesicles as efficient anticancer agents". M. Helena Garcia*, Leonor Côrte-Real, Alejandro P. Soto, Catarina Rodrigues, Alexandra R. Fernandes, Andreia Valente SILQCOM 2017
(Puerto Iguazú, Misiones, Argentina)
2017/08 "Ruthenium-cyclopentadienyl' moiety: a versatile scaffold for the design of anticancer agents". Andreia Valente*, Adhan Pilon, Anabela Sanches, Leonor Côrte-Real, Ricardo Teixeira, M. Helena Garcia SILQCOM 2017
(Puerto Iguazú, Misiones, Argentina)
2017/02 |Speaker| "New self-assembled polymer-metal compounds: highly efficient anticancer vesicles". Leonor Côrte-Real*, Alejandro P. Soto, Ana S. Viana, Alexandra R. Fernandes, M. Helena Garcia, Andreia Valente Chem&BioChem Postgraduate Students Meeting
(Lisboa, Portugal)
2016/11 |Invited co-author| "Targeting cancer with new multifunctional metallodrugs". Andreia Valente*, Leonor Côrte-Real, Tiago Moreira, Ana Preto, M. Helena Garcia World Congress on Cancer Research and Therapy
(Miami, Flórida, United States)
2016/09 |Speaker| "Self-assembled polymer-ruthenium micelles: new promising anticancer agents". Leonor Côrte-Real*, Alejandro P. Soto, Ana S. Viana, M. Helena Garcia, Andreia Valente 3rd European Conference on Smart Inorganic Polymers
(Porto, Portugal)
2016/06 |Invited co-author| "Polymer-metal conjugates: versatile scaffolds for the synthesis of new antitumor drugs". Andreia Valente*, Leonor Côrte-Real, Guilherme Nogueira, Anabela Sanches, Fernanda Marques, Francisco Tortosa, Fátima Gärtner, Nuno Mendes, M. Helena Garcia European Chemistry Congress
(Roma, Italy)
2016/05/24 |Invited Speaker| "Nano-terapia dirigida: uma nova aposta no combate ao cancro". Leonor Côrte-Real* Jornadas da Química Tecnológica
Faculdade de Ciências da Universidade de Lisboa (Lisboa, Portugal)
2016/05/18 |Invited Speaker| "Nano-terapia dirigida: uma nova aposta no combate ao cancro". Leonor Côrte-Real* JobShop
Faculdade de Ciências da Universidade de Lisboa (Lisboa, Portugal)
2016/04 |Speaker| "Self-assembled polymer-metal micelles: new promising anticancer agents". Leonor Côrte-Real*, M. Helena Garcia, Ana S. Viana, Andreia Valente 5PYChem/EUChem
(Guimarães, Portugal)
2015/09 "Multifunctional polymer-ruthenium conjugates: new promising anticancer agents". Andreia Valente*, Leonor Côrte-Real, António P. Matos, M. Helena Garcia, Fernanda Marques 2nd European Conference on Smart Inorganic Polymers
(Upsalla, Sweden)
2014/12 |Invited co-author| "Polymer 'ruthenium-cyclopentadienyl' conjugates: a new approach to fight cancer". Andreia Valente*, M. Helena Garcia, Leonor Côrte-Real, Guilherme Nogueira, Philippe Zinck, António Matos, Fernanda Marques 3rd International Conference on Medicinal Chemistry & Computer Aided Drug Designing
(San Francisco, United States)
2014/11 "Ultrastructural studies of the cellular effects of antitumoral compounds". António P. Matos*, Fernanda Marques, Leonor Côrte-Real, M. Helena Garcia INCOMAM'14, International Conference on Microscopy and Microanalysis, XLVIII Congress of the Portuguese Microscopy Society
(Porto, Portugal)
2013/09 "Novel Pathways for Anticancer Therapy: the Role of Golgi network in the mechanism of cell death of organometallic complexes". Fernanda Marques*, António P. Matos, Leonor Côrte-Real, Tânia S. Morais, Ana Isabel Tomaz, M. Helena Garcia, Manuel P. Bicho Microscopy at the Frontiers of Science, 2013: 3rd Joint Congress of the Portuguese and Spanish Microscopy Societies and Israel Society for Microscopy
(Tarragona, Spain)
2012/09 "Intracellular distribution of antitumor Ru (II) compounds: The lysosome and the lysosomal enzymes as targets for anticancer metal-based drugs". Fernanda Marques*, Leonor Côrte-Real, António P. Matos, Irina Alho, Tânia S. Morais, Ana Isabel Tomaz, M. Helena Garcia, Manuel P. Bicho XLVI Congress of the Portuguese Society for Microscopy
(Centro Hospitalar de Lisboa Central - Hospital D. Estefânia, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2024/06 - 2024/06 Synthesis, characterization and UV-Vis titration studies of a novel Schiff base containing 8-hydroxyquinoline and coumarin moieties
Supervisor of Iryna Pavliuk
2024/01 - 2024/05 Synthesis and characterization of Schiff and Mannich bases and their metal compounds as promising anti-cancer agents
Supervisor of Ronan Chamaillard
2023/05 - 2023/08 Characterization and protein binding studies of Ni(II) complexes based on a hydroxyquinoline Schiff base scaffold
Supervisor of Mael Dejoux
2022/05 - 2022/07 Metal complexes of 8-hydroxyquinoline reduced Schiff bases: synthesis, characterization and solution behavior
Supervisor of Nathan Dubreucq
2021 - 2022 Bases de Schiff derivadas de 8-hidroxyquinolina: Síntese e coordenação a metais de transição
Supervisor of Márcia Venâncio
 Project in Chemistry (Undergraduate Student) (Degree)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2021 - 2022 Zn(II) complexes with Schiff bases of hydroxyquinoline: Characterization and protein binding
Supervisor of Raquel Colucas
 Project in Biochemistry (Undergraduate Student) (Degree)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2021 - 2022 Complexos de cobre(II) com bases de Schiff de 8-hidroxiquinolina: coordenação e reatividade
Supervisor of Matilde Martins
 Project in Biochemistry (Undergraduate Student) (Degree)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2021 - 2021 Development of new metallodrugs for targeted cancer therapy
Supervisor of Ana Dugopoljac
 Erasmus programme (Degree)
Universidade de Lisboa Faculdade de Ciências, Portugal
2020 - 2020 Síntese e caracterização de complexos bimetálicos com potencial aplicação como agentes anti-tumorais
Supervisor of Neuza Salgado
 Project in Chemistry (Undergraduate Student) (Degree)
Universidade de Lisboa Faculdade de Ciências, Portugal
2019 - 2020 Síntese e caracterização de complexos de Molibdénio como sistemas de libertação de CO para o tratamento do cancro
Supervisor of Marcelo Nunes
 Project in Chemistry (Undergraduate Student) (Degree)
Universidade de Lisboa Faculdade de Ciências, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023/01 - Current Member of the organizing committee of the 13th International Vanadium Symposium, V13 (2023/11/22 - 2023/11/24)
Conference (Member of the Organising Committee)
 Universidade de Lisboa Instituto Superior Técnico, Portugal
2021/08/25 - 2021/08/27 Member of the organizing committee of the 2nd European Nectar Conference, Cost Action CA18202 (2021/08/25 - 2021/08/27)
Conference (Member of the Organising Committee)
 Universidade de Lisboa Instituto Superior Técnico, Portugal
2017/02/09 - 2017/02/09 Member of the organizing committee of Chem&BioChem Postgraduate Students Meeting (2017/02/09 - 2017/02/09)
Meeting (Member of the Organising Committee)
 Universidade de Lisboa Faculdade de Ciências, Portugal
2012/09/01 - 2012/09/07 Student volunteer participant at the XXV International Conference on Organometallic Chemistry (XXV ICOMC) (2012/09/01 - 2012/09/07)
Conference (Other)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2018 - Current |Complementary training| - Short Course for Quantitative Real Time PCR Theories and Instrument Operation
Workshop
Rutgers The State University of New Jersey, United States
2016 - Current |Complementary training| - 3rd EuSIPs Training School, COST (CM1302 - Smart Inorganic Polymers)
Workshop
Universidade do Porto, Portugal
2015 - Current |Complementary Training| - Modern Methods of Structural Elucidation Course 2015 (theoretical and practical modules)
Workshop
Universidade de Lisboa Instituto Superior Técnico, Portugal
2023/12/11 - 2023/12/15 |Complementary training| - Basic principles of Nanomedicines R&D Course
Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/05/08 - 2023/05/12 |Complementary training| - Basic, Advanced & Hands-On modules of the 4th edition of FLxFlow Course: Principles and Applications of Flow Cytometry
Fundação Champalimaud, Portugal

Association member

Society Organization name Role
2015 - Current Sociedade Portuguesa de Química (SPQ) Member

Committee member

Activity description
Role 		Institution / Organization
2021 - 2022 Member of the Welcome Committee at CQE
Member
 Universidade de Lisboa Instituto Superior Técnico, Portugal

Mentoring / Tutoring

Topic Student name
2023/06 - 2023/07 Synthesis of new ligands and metal complexes of 8-hydroxyquinoline derivatives Hilda Kovács
2022/05 - 2022/07 Erasmus+ end of course internship Alice Alborghetti
Distinctions

Award

2020 Best Oral Communication at the 13th National Organic Chemistry Meeting (13ENQO) and the 6th National Medicinal Chemistry Meeting (6ENQT), in Aveiro, Portugal
Universidade de Aveiro, Portugal
2019 Portuguese representative at the 6th Young Medicinal Chemist Symposium in Athens, Greece
Sociedade Portuguesa de Química, Portugal
2017 Fulbright grant with the support of FCT for the academic year 2017/2018
Fulbright Association, United States
2017 Best oral communication Chem&BioChem Postgraduate Students Meeting, 9th February 2017, Faculdade de Ciências da Universidade de Lisboa
Hovione, Portugal