Artigo em revista |
- Antas, Pedro; Carvalho, Cláudia; Cabral-Teixeira, Joaquim; de Lemos, Luísa; Seabra, MC. "Toward low-cost gene therapy: mRNA-based
therapeutics for treatment of inherited retinal diseases". Trends in Molecular Medicine (2023): http://dx.doi.org/10.1016/j.molmed.2023.11.009.
Acesso aberto • Publicado • 10.1016/j.molmed.2023.11.009
- Cardoso, M. Helena; Hall, Michael J.; Burgoyne, Thomas; Fale, Pedro; Storm, Tina; Escrevente, Cristina; Antas, Pedro; Seabra,
MC; Futter, Clare E.. Autor correspondente: Futter, Clare E.. "Impaired Lysosome Reformation in Chloroquine-Treated Retinal
Pigment Epithelial Cells". Investigative Opthalmology & Visual Science 64 11 (2023): 10. http://dx.doi.org/10.1167/iovs.64.11.10.
Acesso aberto • Publicado • 10.1167/iovs.64.11.10
- Flores, Rita; Fradinho, Ana C.; Pereira, Rita Serras; Mendes, Jorge M.; Seabra, MC; Tenreiro, Sandra; Carneiro, Ângela. Autor
correspondente: Flores, Rita. "Identifying Imaging Predictors of Intermediate Age-Related Macular Degeneration Progression".
Translational Vision Science & Technology 12 7 (2023): 22. http://dx.doi.org/10.1167/tvst.12.7.22.
Acesso aberto • Publicado • 10.1167/tvst.12.7.22
- Bento-Lopes, Liliana; Cabaço, Luís C.; Charneca, João; Neto, Matilde V.; Seabra, MC; Barral, Duarte C.. Autor correspondente:
Barral, Duarte C.. "Melanin’s Journey from Melanocytes to Keratinocytes: Uncovering the Molecular Mechanisms of Melanin Transfer
and Processing". International Journal of Molecular Sciences 24 14 (2023): 11289. http://dx.doi.org/10.3390/ijms241411289.
Publicado • 10.3390/ijms241411289
- Burrinha, Tatiana; Cunha, César; Hall, Michael J.; Lopes-da-Silva, Mafalda; Seabra, MC; Guimas Almeida, Cláudia. Autor correspondente:
Guimas Almeida, Cláudia. "Deacidification of endolysosomes by neuronal aging drives synapse loss". Traffic 24 8 (2023):
334-354. http://dx.doi.org/10.1111/tra.12889.
Acesso aberto • Publicado • 10.1111/tra.12889
- Rosado-Ramos, Rita; Poças, Gonçalo M.; Marques, Daniela; Foito, Alexandre; M. Sevillano, David; Lopes-da-Silva, Mafalda; Gonçalves,
Luís G.; et al. Autor correspondente: Santos, Cláudia N.. "Genipin prevents alpha-synuclein aggregation and toxicity by affecting
endocytosis, metabolism and lipid storage". Nature Communications 14 1 (2023): http://dx.doi.org/10.1038/s41467-023-37561-2.
Acesso aberto • Publicado • 10.1038/s41467-023-37561-2
- Dias, Sarah Batista; de Lemos, Luísa; Sousa, Luís; Bitoque, Diogo B.; Silva, Gabriela Araújo; Seabra, Miguel C.; Tenreiro,
Sandra. "Age-Related Changes of the Synucleins Profile in the Mouse Retina". Biomolecules 13 1 (2023): 180. http://dx.doi.org/10.3390/biom13010180.
Acesso aberto • Aceite para publicação • 10.3390/biom13010180
- Cabral, Diogo; Ramtohul, Prithvi; Kaden, Talia R.; Tenreiro, Sandra; Seabra, Miguel C.; Freund, K. Bailey. "Hyperpigmented
epiretinal membrane in macular telangiectasia type 2: imaging characteristics and correlation with transretinal pigment migration".
Eye (2022): http://dx.doi.org/10.1038/s41433-022-02260-7.
No prelo • 10.1038/s41433-022-02260-7
- Cabaço, Luís C.; Bento-Lopes, Liliana; Neto, Matilde V.; Ferreira, Andreia; Staubli, Wanja B.L.; Ramalho, José S.; Seabra,
Miguel C.; Barral, Duarte C.. "RAB3A Regulates Melanin Exocytosis and Transfer Induced by Keratinocyte-Conditioned Medium".
JID Innovations 2 5 (2022): 100139. http://dx.doi.org/10.1016/j.xjidi.2022.100139.
Acesso aberto • 10.1016/j.xjidi.2022.100139
- Cabral, Diogo; Fradinho, Ana C.; Pereira, Telmo; Ramakrishnan, Meera S.; Bacci, Tommaso; An, Dong; Tenreiro, Sandra; et al.
Autor correspondente: Freund, K. Bailey. "Macular Vascular Imaging and Connectivity Analysis Using High-Resolution Optical
Coherence Tomography". Translational Vision Science & Technology 11 6 (2022): 2. http://dx.doi.org/10.1167/tvst.11.6.2.
Acesso aberto • Publicado • 10.1167/tvst.11.6.2
- Flores, Rita; Carneiro, Ângela; Neri, Guilherme; Fradinho, Ana C.; Quenderra, Bruno; Barata, Maria João; Tenreiro, Sandra;
Seabra, MC. Autor correspondente: Flores, Rita. "Choroidal Vascular Impairment in Intermediate Age-Related Macular Degeneration".
Diagnostics 12 5 (2022): 1290. http://dx.doi.org/10.3390/diagnostics12051290.
Acesso aberto • Publicado • 10.3390/diagnostics12051290
- Moreiras, Hugo; Bento-Lopes, Liliana; Neto, Matilde V.; Escrevente, Cristina; Cabaço, Luís C.; Hall, Michael J.; Ramalho,
José S.; Seabra, MC; Barral, Duarte C.. Autor correspondente: Barral, Duarte C.. "Melanocore uptake by keratinocytes occurs
through phagocytosis and involves protease-activated receptor-2 internalization". Traffic 23 6 (2022): 331-345. http://dx.doi.org/10.1111/tra.12843.
Publicado • 10.1111/tra.12843
- Barral, Duarte C.; Staiano, Leopoldo; Guimas Almeida, Cláudia; Cutler, Dan F.; Eden, Emily R.; Futter, Clare E.; Galione,
Antony; et al. Autor correspondente: Seabra, MC. "Current methods to analyze lysosome morphology, positioning, motility and
function". Traffic 23 5 (2022): 238-269. http://dx.doi.org/10.1111/tra.12839.
Acesso aberto • Publicado • 10.1111/tra.12839
- Hall, Michael J.; Lopes-Ventura, Sara; Neto, Matilde V.; Charneca, João; Zoio, Patricia; Seabra, MC; Oliva, Abel; Barral,
Duarte C.. Autor correspondente: Barral, Duarte C.. "Reconstructed human pigmented skin/epidermis models achieve epidermal
pigmentation through melanocore transfer". Pigment Cell & Melanoma Research 35 4 (2022): 425-435. http://dx.doi.org/10.1111/pcmr.13039.
Publicado • 10.1111/pcmr.13039
- Flores, Rita; Carneiro, Ângela; Tenreiro, Sandra; Seabra, Miguel C.. "Retinal Progression Biomarkers of Early and Intermediate
Age-Related Macular Degeneration". Life 12 1 (2021): 36. http://dx.doi.org/10.3390/life12010036.
Acesso aberto • 10.3390/life12010036
- Escrevente, Cristina; Falcão, Ana S.; Hall, Michael J.; Lopes-da-Silva, Mafalda; Antas, Pedro; Mesquita, Miguel M.; Ferreira,
Inês S.; et al. "Formation of Lipofuscin-Like Autofluorescent Granules in the Retinal Pigment Epithelium Requires Lysosome
Dysfunction". Investigative Opthalmology & Visual Science 62 9 (2021): 39. http://dx.doi.org/10.1167/iovs.62.9.39.
Acesso aberto • Publicado • 10.1167/iovs.62.9.39
- Flores, Rita; Carneiro, Ângela; Vieira, Miguel; Tenreiro, Sandra; Seabra, Miguel C.. "Age-Related Macular Degeneration: Pathophysiology,
Management, and Future Perspectives". Ophthalmologica (2021): http://dx.doi.org/10.1159/000517520.
Acesso aberto • Publicado • 10.1159/000517520
- Moreiras, Hugo; Seabra, Miguel C.; Barral, Duarte C.. "Melanin Transfer in the Epidermis: The Pursuit of Skin Pigmentation
Control Mechanisms". International Journal of Molecular Sciences 22 9 (2021): 4466. http://dx.doi.org/10.3390/ijms22094466.
Acesso aberto • 10.3390/ijms22094466
- Meschede, Ingrid P.; Burgoyne, Thomas; Tolmachova, Tanya; Seabra, Miguel C.; Futter, Clare E.. "Chronically shortened rod
outer segments accompany photoreceptor cell death in Choroideremia". PLOS ONE 15 11 (2020): e0242284. http://dx.doi.org/10.1371/journal.pone.0242284.
Publicado • 10.1371/journal.pone.0242284
- Flores, Rita; Carneiro, Angela; Serra, Joana; Gouveia, Nélia; Pereira, Telmo; Mendes, Jorge M.; Coelho, Pedro S.; Tenreiro,
Sandra; Seabra, Miguel C.. "CORRELATION STUDY BETWEEN DRUSEN MORPHOLOGY AND FUNDUS AUTOFLUORESCENCE". Retina Publish
Ah (2020): http://dx.doi.org/10.1097/iae.0000000000002881.
Publicado • 10.1097/iae.0000000000002881
- Meschede, Ingrid P.; Ovenden, Nicholas C.; Seabra, Miguel C.; Futter, Clare E.; Votruba, Marcela; Cheetham, Michael E.; Burgoyne,
Thomas. "Symmetric arrangement of mitochondria:plasma membrane contacts between adjacent photoreceptor cells regulated by
Opa1". Proceedings of the National Academy of Sciences 117 27 (2020): 15684-15693. http://dx.doi.org/10.1073/pnas.2000304117.
Acesso aberto • Publicado • 10.1073/pnas.2000304117
- Gross, Tilman; Wack, Gesine; Syhr, Katharina M. J.; Tolmachova, Tanya; Seabra, Miguel C.; Geisslinger, Gerd; Niederberger,
Ellen; Schmidtko, Achim; Kallenborn-Gerhardt, Wiebke. "Rab27a Contributes to the Processing of Inflammatory Pain in Mice".
Cells 9 6 (2020): 1488. http://dx.doi.org/10.3390/cells9061488.
10.3390/cells9061488
- Miguel C. Seabra. "Transfer of extracellular vesicle-microRNA controls germinal center reaction and antibody production.".
EMBO reports (2020): https://europepmc.org/articles/PMC7132182.
10.15252/embr.201948925
- Miguel C. Seabra. "The exocyst is required for melanin exocytosis from melanocytes and transfer to keratinocytes.". Pigment
cell & melanoma research (2019): https://doi.org/10.1111/pcmr.12840.
10.1111/pcmr.12840
- Hayes, Matthew J.; Burgoyne, Thomas; Wavre-Shapton, Silene T.; Tolmachova, Tanya; Seabra, Miguel C.; Futter, Clare E.. "Remodeling
of the Basal Labyrinth of Retinal Pigment Epithelial Cells With Osmotic Challenge, Age, and Disease". Investigative Opthalmology
& Visual Science 60 7 (2019): 2515. http://dx.doi.org/10.1167/iovs.19-26784.
Acesso aberto • Publicado • 10.1167/iovs.19-26784
- Miguel C. Seabra. "Remodeling of the Basal Labyrinth of Retinal Pigment Epithelial Cells With Osmotic Challenge, Age, and
Disease.". Investigative ophthalmology & visual science (2019): https://europepmc.org/articles/PMC6564051.
10.1167/iovs.19-26784
- Storck, Elisabeth M.; Morales-Sanfrutos, Julia; Serwa, Remigiusz A.; Panyain, Nattawadee; Lanyon-Hogg, Thomas; Tolmachova,
Tanya; Ventimiglia, Leandro N.; et al. "Dual chemical probes enable quantitative system-wide analysis of protein prenylation
and prenylation dynamics". Nature Chemistry 11 6 (2019): 552-561. http://dx.doi.org/10.1038/s41557-019-0237-6.
Acesso aberto • 10.1038/s41557-019-0237-6
- Sanzà, Paolo; Evans, Richard D.; Briggs, Deborah A.; Cantero, Marta; Montoliu, Lluis; Patel, Shyamal; Sviderskaya, Elena V.;
et al. "Nucleotide exchange factor Rab3GEP requires DENN and non-DENN elements for activation and targeting of Rab27a". Journal
of Cell Science 132 9 (2019): jcs212035. http://dx.doi.org/10.1242/jcs.212035.
Acesso aberto • Publicado • 10.1242/jcs.212035
- Moreiras, Hugo; Lopes-da-Silva, Mafalda; Seabra, Miguel C.; Barral, Duarte C.. "Melanin processing by keratinocytes: A non-microbial
type of host-pathogen interaction?". Traffic 20 4 (2019): 301-304. http://dx.doi.org/10.1111/tra.12638.
Acesso aberto • Publicado • 10.1111/tra.12638
- Hume, Alistair N.; Seabra, Miguel C.; Figueiredo, Ana C.; Itzen, Aymelt; Sviderskaya, Elena V.; Patel, Shyamal; Montoliu,
Lluis; et al. "Nucleotide exchange factor Rab3GEP requires DENN and non- DENN elements for activation and targeting of Rab27a".
Journal of Cell Science (2019): https://publons.com/publon/21577431/.
10.1242/JCS.212035
- Xue, Kanmin; Jolly, Jasleen K; Barnard, Alun R.; Rudenko, Anna; Salvetti, Anna P.; Patrício, Maria I.; Edwards, Thomas L.;
et al. "Beneficial effects on vision in patients undergoing retinal gene therapy for choroideremia". Nature Medicine
24 10 (2018): 1507-1512. http://dx.doi.org/10.1038/s41591-018-0185-5.
Acesso aberto • 10.1038/s41591-018-0185-5
- Dimopoulos, Ioannis S.; Hoang, Stephanie C.; Radziwon, Alina; Binczyk, Natalia M.; Seabra, Miguel C.; MacLaren, Robert E.;
Somani, Rizwan; Tennant, Matthew T.S.; MacDonald, Ian M.. "Two-Year Results After AAV2-Mediated Gene Therapy for Choroideremia:
The Alberta Experience". American Journal of Ophthalmology 193 (2018): 130-142. http://dx.doi.org/10.1016/j.ajo.2018.06.011.
Acesso aberto • 10.1016/j.ajo.2018.06.011
- Seixas, Elsa; Escrevente, Cristina; Seabra, Miguel C.; Barral, Duarte C.. "Rab GTPase regulation of bacteria and protozoa
phagocytosis occurs through the modulation of phagocytic receptor surface expression". Scientific Reports 8 1 (2018):
http://dx.doi.org/10.1038/s41598-018-31171-5.
Acesso aberto • 10.1038/s41598-018-31171-5
- Correia, Maria S.; Moreiras, Hugo; Pereira, Francisco J.C.; Neto, Matilde V.; Festas, Tiago C.; Tarafder, Abul K.; Ramalho,
José S.; Seabra, Miguel C.; Barral, Duarte C.. "Melanin Transferred to Keratinocytes Resides in Nondegradative Endocytic Compartments".
Journal of Investigative Dermatology 138 3 (2018): 637-646. http://dx.doi.org/10.1016/j.jid.2017.09.042.
Publicado • 10.1016/j.jid.2017.09.042
- Seabra, Miguel C.; Jolly, Jasleen K.; Webster, Andrew; Black, Graeme; Lotery, Andrew; Downes, Susan; Edwards, Thomas L.; et
al. "Retinal Gene Therapy for Choroideremia in a Multicenter Dose Escalation Phase I/II Clinical Trial". Investigative
Ophthalmology & Visual Science (2018): https://publons.com/publon/21577433/.
- Alexander, Margaret; Ramstead, Andrew G.; Bauer, Kaylyn M.; Lee, Soh-Hyun; Runtsch, Marah C.; Wallace, Jared; Huffaker, Thomas
B.; et al. "Rab27-Dependent Exosome Production Inhibits Chronic Inflammation and Enables Acute Responses to Inflammatory Stimuli".
The Journal of Immunology 199 10 (2017): 3559-3570. http://dx.doi.org/10.4049/jimmunol.1700904.
Acesso aberto • Publicado • 10.4049/jimmunol.1700904
- Edwards, Thomas L.; Jolly, Jasleen K.; Groppe, Markus; Barnard, Alun R.; Cottriall, Charles L.; Tolmachova, Tanya; Black,
Graeme C.; et al. "Visual Acuity after Retinal Gene Therapy for Choroideremia". New England Journal of Medicine 374
20 (2016): 1996-1998. http://dx.doi.org/10.1056/nejmc1509501.
Acesso aberto • 10.1056/nejmc1509501
- Wankel, Bret; Ouyang, Jiangyong; Guo, Xuemei; Hadjiolova, Krassimira; Miller, Jeremy; Liao, Yi; Tham, Daniel Kai Long; et
al. "Sequential and compartmentalized action of Rabs, SNAREs, and MAL in the apical delivery of fusiform vesicles in urothelial
umbrella cells". Molecular Biology of the Cell 27 10 (2016): 1621-1634. http://dx.doi.org/10.1091/mbc.e15-04-0230.
Acesso aberto • Publicado • 10.1091/mbc.e15-04-0230
- Seabra, Miguel; Webster, Andrew; Lotery, Andrew J.; Black, Graeme C. M.; Holder, Graham E.; Downes, Susan; Xue, Kanmin; et
al. "Long term vision results following retinal gene therapy for choroideremia". Investigative Ophthalmology & Visual Science
(2016): https://publons.com/publon/21577439/.
- "Sequential and compartmentalized action of Rabs, SNAREs, and MAL in the apical delivery of fusiform vesicles in urothelial
umbrella cells". Molecular biology of the cell (2016): http://europepmc.org/articles/PMC4865319.
10.1091/mbc.E15-04-0230
- "Correction: A Role for Na+,K+-ATPase a1 in Regulating Rab27a Localisation on Melanosomes". PloS one (2016): http://europepmc.org/articles/PMC4740420.
10.1371/journal.pone.0148719
- Burgoyne, Thomas; Meschede, Ingrid P.; Burden, Jemima J.; Bailly, Maryse; Seabra, Miguel C.; Futter, Clare E.. "Rod disc renewal
occurs by evagination of the ciliary plasma membrane that makes cadherin-based contacts with the inner segment". Proceedings
of the National Academy of Sciences 112 52 (2015): 15922-15927. http://dx.doi.org/10.1073/pnas.1509285113.
Acesso aberto • Publicado • 10.1073/pnas.1509285113
- Thieleke-Matos, Carolina; Lopes da Silva, Mafalda; Cabrita-Santos, Laura; Portal, Martim D.; Rodrigues, Inês P.; Zuzarte-Luis,
Vanessa; Ramalho, José S.; et al. "Host cell autophagy contributes to
Plasmodium
liver development". Cellular Microbiology 18 3 (2015): 437-450. http://dx.doi.org/10.1111/cmi.12524.
Acesso aberto • 10.1111/cmi.12524
- Reichhart, Nadine; Markowski, Magdalena; Ishiyama, Shimpei; Wagner, Andrea; Crespo-Garcia, Sergio; Schorb, Talitha; Ramalho,
José S.; et al. "Rab27a GTPase modulates L-type Ca 2+ channel function via interaction with the II–III linker of Ca V 1.3
subunit". Cellular Signalling 27 11 (2015): 2231-2240. http://dx.doi.org/10.1016/j.cellsig.2015.07.023.
Publicado • 10.1016/j.cellsig.2015.07.023
- Wavre-Shapton, Silène T.; Calvi, Alessandra A.; Turmaine, Mark; Seabra, Miguel C.; Cutler, Daniel F.; Futter, Clare E.; Mitchison,
Hannah M.. "Photoreceptor phagosome processing defects and disturbed autophagy in retinal pigment epithelium ofCln3¿ex1-6mice
modelling juvenile neuronal ceroid lipofuscinosis (Batten disease)". Human Molecular Genetics (2015): ddv406. http://dx.doi.org/10.1093/hmg/ddv406.
10.1093/hmg/ddv406
- Alexander, Margaret; Hu, Ruozhen; Runtsch, Marah C.; Kagele, Dominique A.; Mosbruger, Timothy L.; Tolmachova, Tanya; Seabra,
Miguel C.; et al. "Exosome-delivered microRNAs modulate the inflammatory response to endotoxin". Nature Communications
6 1 (2015): http://dx.doi.org/10.1038/ncomms8321.
Acesso aberto • 10.1038/ncomms8321
- Alexander, Margaret; Hu, Ruozhen; Runtsch, Marah C.; Kagele, Dominique A.; Mosbruger, Timothy L.; Tolmachova, Tanya; Seabra,
Miguel C.; et al. "Exosome-delivered microRNAs modulate the inflammatory response to endotoxin". Nature Communications
6 1 (2015): http://dx.doi.org/10.1038/ncomms8321.
Acesso aberto • Publicado • 10.1038/ncomms8321
- Walker, B.; Schmid, E.; Russo, A.; Schmidt, E.-M.; Burk, O.; Münzer, P.; Velic, A.; et al. "Impact of the serum- and glucocorticoid-inducible
kinase 1 on platelet dense granule biogenesis and secretion". Journal of Thrombosis and Haemostasis 13 7 (2015): 1325-1334.
http://dx.doi.org/10.1111/jth.12998.
Acesso aberto • Publicado • 10.1111/jth.12998
- Burgoyne, T.; O'Connor, M. N.; Seabra, M. C.; Cutler, D. F.; Futter, C. E.. "Regulation of melanosome number, shape and movement
in the zebrafish retinal pigment epithelium by OA1 and PMEL". Journal of Cell Science 128 7 (2015): 1400-1407. http://dx.doi.org/10.1242/jcs.164400.
Acesso aberto • Publicado • 10.1242/jcs.164400
- Singh, Rajesh K; Furze, Rebecca C; Birrell, Mark A; Rankin, Sara M; Hume, Alistair N; Seabra, Miguel C. "A role for Rab27
in neutrophil chemotaxis and lung recruitment". BMC Cell Biology 15 1 (2014): http://dx.doi.org/10.1186/s12860-014-0039-z.
Acesso aberto • Publicado • 10.1186/s12860-014-0039-z
- Hume, Alistair N.; Seabra, Miguel C.. "Melanoma goes on a diet to get moving: toning down phagocytic Rab7 expression helps
melanoma to metastasise". Pigment Cell & Melanoma Research 27 6 (2014): 1012-1013. http://dx.doi.org/10.1111/pcmr.12310.
Publicado • 10.1111/pcmr.12310
- Okoye, Isobel S.; Coomes, Stephanie M.; Pelly, Victoria S.; Czieso, Stephanie; Papayannopoulos, Venizelos; Tolmachova, Tanya;
Seabra, Miguel C.; Wilson, Mark S.. "MicroRNA-Containing T-Regulatory-Cell-Derived Exosomes Suppress Pathogenic T Helper 1
Cells". Immunity 41 3 (2014): 503. http://dx.doi.org/10.1016/j.immuni.2014.08.008.
Acesso aberto • 10.1016/j.immuni.2014.08.008
- Thieleke-Matos, Carolina; da Silva, Mafalda Lopes; Cabrita-Santos, Laura; Pires, Cristiana F.; Ramalho, José S.; Ikonomov,
Ognian; Seixas, Elsa; et al. "Host PI(3,5)P2Activity Is Required forPlasmodium bergheiGrowth During Liver Stage Infection".
Traffic 15 10 (2014): 1066-1082. http://dx.doi.org/10.1111/tra.12190.
Acesso aberto • Publicado • 10.1111/tra.12190
- Wavre-Shapton, S. T.; Meschede, I. P.; Seabra, M. C.; Futter, C. E.. "Phagosome maturation during endosome interaction revealed
by partial rhodopsin processing in retinal pigment epithelium". Journal of Cell Science 127 17 (2014): 3852-3861. http://dx.doi.org/10.1242/jcs.154757.
Acesso aberto • Publicado • 10.1242/jcs.154757
- Booth, Antonia E. G.; Tarafder, Abul K.; Hume, Alistair N.; Recchi, Chiara; Seabra, Miguel C.. "A Role for Na+,K+-ATPase a1
in Regulating Rab27a Localisation on Melanosomes". PLoS ONE 9 7 (2014): e102851. http://dx.doi.org/10.1371/journal.pone.0102851.
Acesso aberto • Publicado • 10.1371/journal.pone.0102851
- Tarafder, Abul K.; Bolasco, Giulia; Correia, Maria S.; Pereira, Francisco J.C.; Iannone, Lucio; Hume, Alistair N.; Kirkpatrick,
Niall; et al. "Rab11b Mediates Melanin Transfer between Donor Melanocytes and Acceptor Keratinocytes via Coupled Exo/Endocytosis".
Journal of Investigative Dermatology 134 4 (2014): 1056-1066. http://dx.doi.org/10.1038/jid.2013.432.
Publicado • 10.1038/jid.2013.432
- MacLaren, Robert E; Groppe, Markus; Barnard, Alun R; Cottriall, Charles L; Tolmachova, Tanya; Seymour, Len; Clark, K Reed;
et al. "Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial". The Lancet
383 9923 (2014): 1129-1137. http://dx.doi.org/10.1016/s0140-6736(13)62117-0.
Acesso aberto • 10.1016/s0140-6736(13)62117-0
- Seabra, Miguel C.; Webster, Andrew; Downes, Susan M.; Lotery, Andrew; Black, Graeme C.; Cremers, Frans P.; Tolmachova, Tanya;
et al. "Improved visual function in patients with choroideremia undergoing subretinal gene therapy". Investigative Ophthalmology
& Visual Science (2014): https://publons.com/publon/21577452/.
- Black, A.; Vasireddy, V.; Chung, D.C.; Maguire, A.M.; Gaddameedi, R.; Tolmachova, T.; Seabra, M.; Bennett, J.. "Adeno-associated
virus 8-mediated gene therapy for choroideremia: Preclinical studies in in vitro and in vivo models". Journal of Gene Medicine
16 5-6 (2014): 122-130. http://www.scopus.com/inward/record.url?eid=2-s2.0-84904540483&partnerID=MN8TOARS.
10.1002/jgm.2768
- Burgoyne, T.; Jolly, R.; Martin-Martin, B.; Seabra, M.C.; Piccirillo, R.; Schiaffino, M.V.; Futter, C.E.. "Expression of OA1
limits the fusion of a subset of MVBs with lysosomes - a mechanism potentially involved in the initial biogenesis of melanosomes
[J. Cell Sci. 126, 5143-5152]". Journal of Cell Science 127 3 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84894098374&partnerID=MN8TOARS.
10.1242/jcs.148072
- Seabra, Miguel. "Portugal's research funding is secure". Nature (2014): https://publons.com/publon/21577447/.
10.1038/507306B
- Burgoyne, T.; Jolly, R.; Martin-Martin, B.; Seabra, M. C.; Piccirillo, R.; Schiaffino, M. V.; Futter, C. E.. "Expression of
OA1 limits the fusion of a subset of MVBs with lysosomes - a mechanism potentially involved in the initial biogenesis of melanosomes".
Journal of Cell Science 126 22 (2013): 5143-5152. http://dx.doi.org/10.1242/jcs.128561.
Acesso aberto • Publicado • 10.1242/jcs.128561
- Kim, John Dongil; Willetts, Lian; Ochkur, Sergei; Srivastava, Nutan; Hamburg, Rudolf; Shayeganpour, Anooshirvan; Seabra, Miguel
C.; et al. "An essential role for Rab27a GTPase in eosinophil exocytosis". Journal of Leukocyte Biology 94 6 (2013):
1265-1274. http://dx.doi.org/10.1189/jlb.0812431.
Acesso aberto • 10.1189/jlb.0812431
- Moosajee, Mariya; Ramsden, Simon C; Black, Graeme CM; Seabra, Miguel C; Webster, Andrew R. "Clinical utility gene card for:
Choroideremia". European Journal of Human Genetics 22 4 (2013): 572-572. http://dx.doi.org/10.1038/ejhg.2013.183.
Acesso aberto • 10.1038/ejhg.2013.183
- Tolmachova, Tanya; Tolmachov, Oleg E.; Barnard, Alun R.; de Silva, Samantha R.; Lipinski, Daniel M.; Walker, Nathan J.; MacLaren,
Robert E.; Seabra, Miguel C.. "Functional expression of Rab escort protein 1 following AAV2-mediated gene delivery in the
retina of choroideremia mice and human cells ex vivo". Journal of Molecular Medicine 91 7 (2013): 825-837. http://dx.doi.org/10.1007/s00109-013-1006-4.
Acesso aberto • 10.1007/s00109-013-1006-4
- Kirsten, Marie L.; Baron, Rudi A.; Seabra, Miguel C.; Ces, Oscar. "Rab1a and Rab5a preferentially bind to binary lipid compositions
with higher stored curvature elastic energy". Molecular Membrane Biology 30 4 (2013): 303-314. http://dx.doi.org/10.3109/09687688.2013.818725.
Acesso aberto • 10.3109/09687688.2013.818725
- Seixas, Elsa; Barros, Mafalda; Seabra, Miguel C.; Barral, Duarte C.. "Rab and Arf Proteins in Genetic Diseases". Traffic
14 8 (2013): 871-885. http://dx.doi.org/10.1111/tra.12072.
Acesso aberto • Publicado • 10.1111/tra.12072
- Wavre-Shapton, Silène T.; Tolmachova, Tanya; da Silva, Mafalda Lopes; Futter, Clare E.; Seabra, Miguel C.. "Conditional Ablation
of the Choroideremia Gene Causes Age-Related Changes in Mouse Retinal Pigment Epithelium". PLoS ONE 8 2 (2013): e57769.
http://dx.doi.org/10.1371/journal.pone.0057769.
Acesso aberto • Publicado • 10.1371/journal.pone.0057769
- Miguel C Seabra. "Gene Replacement Therapy for Choroideremia". Molecular Therapy (2013): https://publons.com/publon/21577458/.
- "Correction: Conditional Ablation of the Choroideremia Gene Causes Age-Related Changes in Mouse Retinal Pigment Epithelium".
PloS one (2013): http://europepmc.org/articles/PMC3654017.
10.1371/annotation/83a88285-e6a0-41fb-ae67-4315c21e5090
- Singh, Rajesh K.; Mizuno, Koichi; Wasmeier, Christina; Wavre-Shapton, Silene T.; Recchi, Chiara; Catz, Sergio D.; Futter,
Clare; et al. "Distinct and opposing roles for Rab27a/Mlph/MyoVa and Rab27b/Munc13-4 in mast cell secretion". FEBS Journal
(2012): n/a-n/a. http://dx.doi.org/10.1111/febs.12081.
Acesso aberto • 10.1111/febs.12081
- Bobrie, A.; Krumeich, S.; Reyal, F.; Recchi, C.; Moita, L. F.; Seabra, M. C.; Ostrowski, M.; Thery, C.. "Rab27a Supports Exosome-Dependent
and -Independent Mechanisms That Modify the Tumor Microenvironment and Can Promote Tumor Progression". Cancer Research
72 19 (2012): 4920-4930. http://dx.doi.org/10.1158/0008-5472.can-12-0925.
Acesso aberto • 10.1158/0008-5472.can-12-0925
- Lopes da Silva, Mafalda; Thieleke-Matos, Carolina; Cabrita-Santos, Laura; Ramalho, José S.; Wavre-Shapton, Silène T.; Futter,
Clare E.; Barral, Duarte C.; Seabra, Miguel C.. "The Host Endocytic Pathway is Essential for Plasmodium berghei Late Liver
Stage Development". Traffic 13 10 (2012): 1351-1363. http://dx.doi.org/10.1111/j.1600-0854.2012.01398.x.
Acesso aberto • Publicado • 10.1111/j.1600-0854.2012.01398.x
- Seixas, Elsa; Ramalho, José S.; Mota, Luís J.; Barral, Duarte C.; Seabra, Miguel C.. "Bacteria and Protozoa Differentially
Modulate the Expression of Rab Proteins". PLoS ONE 7 7 (2012): e39858. http://dx.doi.org/10.1371/journal.pone.0039858.
Acesso aberto • Publicado • 10.1371/journal.pone.0039858
- Tolmachova, Tanya; Tolmachov, Oleg E.; Wavre-Shapton, Silene T.; Tracey-White, Dhani; Futter, Clare E.; Seabra, Miguel C..
"CHM/REP1 cDNA delivery by lentiviral vectors provides functional expression of the transgene in the retinal pigment epithelium
of choroideremia mice". The Journal of Gene Medicine 14 3 (2012): 158-168. http://dx.doi.org/10.1002/jgm.1652.
Publicado • 10.1002/jgm.1652
- Seabra, Miguel; Booth AE; Seabra MC; Hume AN. "Rab27a and melanosomes: a model to investigate the membrane targeting of Rabs".
Biochemical Society transactions (2012): https://doi.org/10.1042/BST20120200.
10.1042/bst20120200
- Seabra, Miguel. "Novel functions for Rab GTPases in multiple aspects of tumour progression". Biochemical Society transactions
(2012): http://europepmc.org/articles/PMC3554041.
10.1042/BST20120199
- Hendrix, An; Lambein, Kathleen; Westbroek, Wendy; Seabra, Miguel C.; Cocquyt, Veronique; Pauwels, Patrick; Bracke, Marc; Gespach,
Christian; Wever, Olivier De. "An immunohistochemical analysis of Rab27B distribution in fetal and adult tissue". The International
Journal of Developmental Biology 56 5 (2012): 363-368. http://dx.doi.org/10.1387/ijdb.120008ah.
Acesso aberto • 10.1387/ijdb.120008ah
- Miguel C Seabra. "Molecular characterization of melanin transfer from donor melanocytes to recipient keratinocytes". Molecular
Biology of the Cell (2012): https://publons.com/publon/21577462/.
- Miguel C Seabra. "The Development of Non-Viral Vectors for Choroideremia". Molecular Therapy (2012): https://publons.com/publon/21577466/.
- Miguel C Seabra. "Rab27a-mediated protease release regulates neutrophil recruitment by allowing uropod detachment". Journal
of Cell Science (2012): https://publons.com/publon/21577467/.
10.1242/JCS.100438
- Seabra, Miguel C.; MacLaren, Robert E.; During, Matthew J.; Groppe, Markus; Barnard, Alun R.; Tolmachov, Oleg E.; Tolmachova,
Tanya. "AAV2/2-CBA-REP1 Vector with WPRE Provides Functional Expression of the Transgene in Choroideremia Mouse Knock-Out
and Patient Cells". Molecular Therapy (2012): https://publons.com/publon/21577465/.
- Diekmann, Yoan; Seixas, Elsa; Gouw, Marc; Tavares-Cadete, Filipe; Seabra, Miguel C.; Pereira-Leal, José B.. "Thousands of
Rab GTPases for the Cell Biologist". PLoS Computational Biology 7 10 (2011): e1002217. http://dx.doi.org/10.1371/journal.pcbi.1002217.
Acesso aberto • Publicado • 10.1371/journal.pcbi.1002217
- Hume, Alistair N.; Seabra, Miguel C.. "Melanosomes on the move: a model to understand organelle dynamics". Biochemical
Society Transactions 39 5 (2011): 1191-1196. http://dx.doi.org/10.1042/bst0391191.
Publicado • 10.1042/bst0391191
- Rojo Pulido, Inés; Nightingale, Thomas D.; Darchen, François; Seabra, Miguel C.; Cutler, Daniel F.; Gerke, Volker. "Myosin
Va Acts in Concert with Rab27a and MyRIP to Regulate Acute Von-Willebrand Factor Release from Endothelial Cells". Traffic
12 10 (2011): 1371-1382. http://dx.doi.org/10.1111/j.1600-0854.2011.01248.x.
Acesso aberto • Publicado • 10.1111/j.1600-0854.2011.01248.x
- Chiang, Lilian; Ngo, Julie; Schechter, Joel E.; Karvar, Serhan; Tolmachova, Tanya; Seabra, Miguel C.; Hume, Alistair N.; Hamm-Alvarez,
Sarah F.. "Rab27b regulates exocytosis of secretory vesicles in acinar epithelial cells from the lacrimal gland". American
Journal of Physiology-Cell Physiology 301 2 (2011): C507-C521. http://dx.doi.org/10.1152/ajpcell.00355.2010.
Acesso aberto • Publicado • 10.1152/ajpcell.00355.2010
- Tarafder, Abul K.; Wasmeier, Christina; Figueiredo, Ana C.; Booth, Antonia E. G.; Orihara, Asumi; Ramalho, Jose S.; Hume,
Alistair N.; Seabra, Miguel C.. "Rab27a Targeting to Melanosomes Requires Nucleotide Exchange but Not Effector Binding". Traffic
12 8 (2011): 1056-1066. http://dx.doi.org/10.1111/j.1600-0854.2011.01216.x.
Acesso aberto • Publicado • 10.1111/j.1600-0854.2011.01216.x
- Taylor, Adam; Mules, Emilie H.; Seabra, Miguel C.; Helfrich, Miep H.; Rogers, Michael J.; Coxon, Fraser P.. "Impaired prenylation
of Rab GTPases in thegunmetalmouse causes defects in bone cell function". Small GTPases 2 3 (2011): 131-142. http://dx.doi.org/10.4161/sgtp.2.3.16488.
Acesso aberto • 10.4161/sgtp.2.3.16488
- Bolasco, Giulia; Tracey-White, Dhani C.; Tolmachova, Tanya; Thorley, Andrew J.; Tetley, Teresa D.; Seabra, Miguel C.; Hume,
Alistair N.. "Loss of Rab27 function results in abnormal lung epithelium structure in mice". American Journal of Physiology-Cell
Physiology 300 3 (2011): C466-C476. http://dx.doi.org/10.1152/ajpcell.00446.2010.
Acesso aberto • 10.1152/ajpcell.00446.2010
- Seabra, Miguel. "Rab27b regulates exocytosis of secretory vesicles in acinar epithelial cells from the lacrimal gland". American
journal of physiology. Cell physiology (2011): http://europepmc.org/articles/PMC3154548.
10.1152/ajpcell.00355.2010
- Seabra, Miguel. "The gunmetal mouse reveals Rab geranylgeranyl transferase to be the major molecular target of phosphonocarboxylate
analogues of bisphosphonates". Bone (2011): https://doi.org/10.1016/j.bone.2011.03.686.
10.1016/j.bone.2011.03.686
- Michael A. Ferenczi. "Semi-Automated Analysis of Organelle Movement and Membrane Content: Understanding Rab-Motor Complex
Transport Function". Traffic (2011): https://publons.com/publon/10397620/.
10.1111/J.1600-0854.2011.01283.X
- McKenna, Charles E.; Ebetino, Frank H.; Seabra, Miguel C.; Rogers, Michael J.; Baron, Rudi; Stewart, Charlotte A.; Coxon,
Fraser P.; et al. "Synthesis, stereochemistry and SAR of a series of minodronate analogues as RGGT inhibitors". European
Journal of Medicinal Chemistry (2011): https://publons.com/publon/2169969/.
10.1016/J.EJMECH.2011.04.063
- Nightingale, T.D.; Pattni, K.; Hume, A.N.; Seabra, M.C.; Cutler, D.F.. "Rab27a and MyRIP regulate the amount and multimeric
state of VWF released from endothelial cells. (Blood (2009) 113, 20, (5010-5018))". Blood 117 12 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-79953124444&partnerID=MN8TOARS.
10.1182/blood-2011-01-329136
- Anderson, Karen E.; Chessa, Tamara A. M.; Davidson, Keith; Henderson, Robert B.; Walker, Simon; Tolmachova, Tanya; Grys, Katarzyna;
et al. "PtdIns3P and Rac direct the assembly of the NADPH oxidase on a novel, pre-phagosomal compartment during FcR-mediated
phagocytosis in primary mouse neutrophils". Blood 116 23 (2010): 4978-4989. http://dx.doi.org/10.1182/blood-2010-03-275602.
Acesso aberto • Publicado • 10.1182/blood-2010-03-275602
- Tolmachova, Tanya; Wavre-Shapton, Silene T.; Barnard, Alun R.; MacLaren, Robert E.; Futter, Clare E.; Seabra, Miguel C.. "Retinal
Pigment Epithelium Defects Accelerate Photoreceptor Degeneration in Cell Type–Specific Knockout Mouse Models of Choroideremia".
Investigative Opthalmology & Visual Science 51 10 (2010): 4913. http://dx.doi.org/10.1167/iovs.09-4892.
Acesso aberto • Publicado • 10.1167/iovs.09-4892
- Hendrix A; Braems G; Bracke M; Seabra M; Gahl W; De Wever O; Westbroek W; et al. "The secretory small GTPase Rab27B as a marker
for breast cancer progression.". Oncotarget (2010): http://europepmc.org/abstract/med/21304180.
Acesso aberto • 10.18632/ONCOTARGET.100809
- Hendrix, An; Maynard, Dawn; Pauwels, Patrick; Braems, Geert; Denys, Hannelore; Van den Broecke, Rudy; Lambert, Jo; et al.
"Effect of the Secretory Small GTPase Rab27B on Breast Cancer Growth, Invasion, and Metastasis". JNCI: Journal of the National
Cancer Institute 102 12 (2010): 866-880. http://dx.doi.org/10.1093/jnci/djq153.
Acesso aberto • 10.1093/jnci/djq153
- Hendrix, An; Maynard, Dawn; Pauwels, Patrick; Braems, Geert; Denys, Hannelore; Van den Broecke, Rudy; Lambert, Jo; et al.
"Effect of the Secretory Small GTPase Rab27B on Breast Cancer Growth, Invasion, and Metastasis". JNCI: Journal of the National
Cancer Institute 102 12 (2010): 866-880. http://dx.doi.org/10.1093/jnci/djq153.
Acesso aberto • Publicado • 10.1093/jnci/djq153
- Ali, Bassam R.; Nouvel, Ian; Leung, Ka Fai; Hume, Alistair N.; Seabra, Miguel C.. "A novel statin-mediated “prenylation block-and-release”
assay provides insight into the membrane targeting mechanisms of small GTPases". Biochemical and Biophysical Research Communications
397 1 (2010): 34-41. http://dx.doi.org/10.1016/j.bbrc.2010.05.045.
Acesso aberto • Publicado • 10.1016/j.bbrc.2010.05.045
- McKenna, Charles E.; Kashemirov, Boris A.; Blaz¿ewska, Katarzyna M.; Mallard-Favier, Isabelle; Stewart, Charlotte A.; Rojas,
Javier; Lundy, Mark W.; et al. "Synthesis, Chiral High Performance Liquid Chromatographic Resolution and Enantiospecific Activity
of a Potent New Geranylgeranyl Transferase Inhibitor, 2-Hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic Acid". Journal
of Medicinal Chemistry 53 9 (2010): 3454-3464. http://dx.doi.org/10.1021/jm900232u.
Acesso aberto • Publicado • 10.1021/jm900232u
- Berry, Alexandra F. H.; Heal, William P.; Tarafder, Abul K.; Tolmachova, Tanya; Baron, Rudi A.; Seabra, Miguel C.; Tate, Edward
W.. "Rapid Multilabel Detection of Geranylgeranylated Proteins by Using Bioorthogonal Ligation Chemistry". ChemBioChem
11 6 (2010): 771-773. http://dx.doi.org/10.1002/cbic.201000087.
10.1002/cbic.201000087
- Frasa, Marieke A.M.; Maximiano, Filipe C.; Smolarczyk, Kasia; Francis, Richard E.; Betson, Martha E.; Lozano, Encarnacion;
Goldenring, James; et al. "Armus Is a Rac1 Effector that Inactivates Rab7 and Regulates E-Cadherin Degradation". Current
Biology 20 3 (2010): 198-208. http://dx.doi.org/10.1016/j.cub.2009.12.053.
Acesso aberto • 10.1016/j.cub.2009.12.053
- Miguel C Seabra. "Rab27a and Rab27b Regulate Neutrophil Azurophilic Granule Exocytosis and NADPH oxidase Activity by Independent
Mechanisms". Traffic (2010): https://publons.com/publon/21577478/.
10.1111/J.1600-0854.2009.01029.X
- Ostrowski, Matias; Carmo, Nuno B.; Krumeich, Sophie; Fanget, Isabelle; Raposo, Graça; Savina, Ariel; Moita, Catarina F.; et
al. "Rab27a and Rab27b control different steps of the exosome secretion pathway". Nature Cell Biology 12 1 (2009):
19-30. http://dx.doi.org/10.1038/ncb2000.
Acesso aberto • Publicado • 10.1038/ncb2000
- Ramalho, José S.; Lopes, Vanda S.; Tarafder, Abul K.; Seabra, Miguel C.; Hume, Alistair N.. "Myrip uses distinct domains in
the cellular activation of myosin VA and myosin VIIA in melanosome transport". Pigment Cell & Melanoma Research 22
4 (2009): 461-473. http://dx.doi.org/10.1111/j.1755-148x.2009.00567.x.
10.1111/j.1755-148x.2009.00567.x
- Moosajee, Mariya; Tulloch, Merrin; Baron, Rudi A.; Gregory-Evans, Cheryl Y.; Pereira-Leal, Jose´ B.; Seabra, Miguel C.. "Single
choroideremia Gene in Non mammalian Vertebrates Explains Early Embryonic Lethality of the Zebrafish Model of Choroideremia".
Investigative Opthalmology & Visual Science 50 6 (2009): 3009. http://dx.doi.org/10.1167/iovs.08-2755.
Publicado • 10.1167/iovs.08-2755
- Nightingale, Thomas D.; Pattni, Krupa; Hume, Alistair N.; Seabra, Miguel C.; Cutler, Daniel F.. "Rab27a and MyRIP regulate
the amount and multimeric state of VWF released from endothelial cells". Blood 113 20 (2009): 5010-5018. http://dx.doi.org/10.1182/blood-2008-09-181206.
Acesso aberto • Publicado • 10.1182/blood-2008-09-181206
- "Phosphonocarboxylates inhibit the second geranylgeranyl addition by Rab geranylgeranyl transferase". The Journal of biological
chemistry (2009): http://europepmc.org/articles/PMC2652301.
10.1074/jbc.M806952200
- Baron, Rudi A.; Tavaré, Richard; Figueiredo, Ana C.; Blazewska, Katarzyna M.; Kashemirov, Boris A.; McKenna, Charles E.; Ebetino,
Frank H.; et al. "Phosphonocarboxylates Inhibit the Second Geranylgeranyl Addition by Rab Geranylgeranyl Transferase". Journal
of Biological Chemistry 284 11 (2008): 6861-6868. http://dx.doi.org/10.1074/jbc.m806952200.
Acesso aberto • Publicado • 10.1074/jbc.m806952200
- Wasmeier, C.; Hume, A. N.; Bolasco, G.; Seabra, M. C.. "Melanosomes at a glance". Journal of Cell Science 121 24 (2008):
3995-3999. http://dx.doi.org/10.1242/jcs.040667.
Acesso aberto • Publicado • 10.1242/jcs.040667
- Hume, A. N.; Buttgereit, J.; Al-Awadhi, A. M.; Al-Suwaidi, S. S.; John, A.; Bader, M.; Seabra, M. C.; Al-Gazali, L.; Ali,
B. R.. "Defective cellular trafficking of missense NPR-B mutants is the major mechanism underlying acromesomelic dysplasia-type
Maroteaux". Human Molecular Genetics 18 2 (2008): 267-277. http://dx.doi.org/10.1093/hmg/ddn354.
Acesso aberto • Publicado • 10.1093/hmg/ddn354
- Baron, Rudi A.; Seabra, Miguel C.. "Rab geranylgeranylation occurs preferentially via the pre-formed REP–RGGT complex and
is regulated by geranylgeranyl pyrophosphate". Biochemical Journal 415 1 (2008): 67-75. http://dx.doi.org/10.1042/bj20080662.
Publicado • 10.1042/bj20080662
- Moosajee, M.; Gregory-Evans, K.; Ellis, C. D.; Seabra, M. C.; Gregory-Evans, C. Y.. "Translational bypass of nonsense mutations
in zebrafish rep1, pax2.1 and lamb1 highlights a viable therapeutic option for untreatable genetic eye disease". Human
Molecular Genetics 17 24 (2008): 3987-4000. http://dx.doi.org/10.1093/hmg/ddn302.
Publicado • 10.1093/hmg/ddn302
- Figueiredo, Ana C.; Wasmeier, Christina; Tarafder, Abul K.; Ramalho, José S.; Baron, Rudi A.; Seabra, Miguel C.. "Rab3GEP
Is the Non-redundant Guanine Nucleotide Exchange Factor for Rab27a in Melanocytes". Journal of Biological Chemistry
283 34 (2008): 23209-23216. http://dx.doi.org/10.1074/jbc.m804134200.
Acesso aberto • Publicado • 10.1074/jbc.m804134200
- "Rab3GEP is the non-redundant guanine nucleotide exchange factor for Rab27a in melanocytes". The Journal of biological
chemistry (2008): http://europepmc.org/articles/PMC2516999.
10.1074/jbc.M804134200
- Coxon, Fraser P.; Rogers, Michael J.; Ebetino, Frank H.; Kashemirov, Boris A.; McKenna, Charles E.; Blazewska, Katarzyna M.;
Seabra, Miguel C.; et al. "Characterisation of the inhibition of rab prenylation by phosphonocarboxylates". Bone (2008):
https://publons.com/publon/11292902/.
10.1016/J.BONE.2007.12.167
- Lopes, Vanda S.; Wasmeier, Christina; Seabra, Miguel C.; Futter, Clare E.. "Melanosome Maturation Defect in Rab38-deficient
Retinal Pigment Epithelium Results in Instability of Immature Melanosomes during Transient Melanogenesis". Molecular Biology
of the Cell 18 10 (2007): 3914-3927. http://dx.doi.org/10.1091/mbc.e07-03-0268.
Acesso aberto • Publicado • 10.1091/mbc.e07-03-0268
- Hume, A. N.; Ushakov, D. S.; Tarafder, A. K.; Ferenczi, M. A.; Seabra, M. C.. "Rab27a and MyoVa are the primary Mlph interactors
regulating melanosome transport in melanocytes". Journal of Cell Science 120 17 (2007): 3111-3122. http://dx.doi.org/10.1242/jcs.010207.
Acesso aberto • Publicado • 10.1242/jcs.010207
- Mizuno, Kouichi; Tolmachova, Tanya; Ushakov, Dmitry S.; Romao, Maryse; Åbrink, Magnus; Ferenczi, Michael A.; Raposo, Graça;
Seabra, Miguel C.. "Rab27b Regulates Mast Cell Granule Dynamics and Secretion". Traffic 8 7 (2007): 883-892. http://dx.doi.org/10.1111/j.1600-0854.2007.00571.x.
Acesso aberto • Publicado • 10.1111/j.1600-0854.2007.00571.x
- Lopes, Vanda S.; Ramalho, José S.; Owen, Dylan M.; Karl, Mike O.; Strauss, Olaf; Futter, Clare E.; Seabra, Miguel C.. "The
Ternary Rab27a-Myrip-Myosin VIIa Complex Regulates Melanosome Motility in the Retinal Pigment Epithelium". Traffic
8 5 (2007): 486-499. http://dx.doi.org/10.1111/j.1600-0854.2007.00548.x.
Acesso aberto • Publicado • 10.1111/j.1600-0854.2007.00548.x
- Tolmachova, T.; Abrink, M.; Futter, C. E.; Authi, K. S.; Seabra, M. C.. "Rab27b regulates number and secretion of platelet
dense granules". Proceedings of the National Academy of Sciences 104 14 (2007): 5872-5877. http://dx.doi.org/10.1073/pnas.0609879104.
Acesso aberto • Publicado • 10.1073/pnas.0609879104
- Jancic, Carolina; Savina, Ariel; Wasmeier, Christina; Tolmachova, Tanya; El-Benna, Jamel; Dang, Pham My-Chan; Pascolo, Steve;
et al. "Rab27a regulates phagosomal pH and NADPH oxidase recruitment to dendritic cell phagosomes". Nature Cell Biology
9 4 (2007): 367-378. http://dx.doi.org/10.1038/ncb1552.
Publicado • 10.1038/ncb1552
- "Melanosome maturation defect in Rab38-deficient retinal pigment epithelium results in instability of immature melanosomes
during transient melanogenesis". Molecular biology of the cell (2007): http://europepmc.org/articles/PMC1995718.
10.1091/mbc.E07-03-0268
- Önfelt, Björn; Nedvetzki, Shlomo; Benninger, Richard K. P.; Purbhoo, Marco A.; Sowinski, Stefanie; Hume, Alistair N.; Seabra,
Miguel C.; et al. "Structurally Distinct Membrane Nanotubes between Human Macrophages Support Long-Distance Vesicular Traffic
or Surfing of Bacteria". The Journal of Immunology 177 12 (2006): 8476-8483. http://dx.doi.org/10.4049/jimmunol.177.12.8476.
Acesso aberto • Publicado • 10.4049/jimmunol.177.12.8476
- Onfelt B; Nedvetzki S; Benninger RK; Purbhoo MA; Sowinski S; Hume AN; Seabra MC; et al. "Structurally distinct membrane nanotubes
between human macrophages support long-distance vesicular traffic or surfing of bacteria.". (2006): http://europepmc.org/abstract/med/17142745.
- Leung, Ka Fai; Baron, Rudi; Ali, Bassam R.; Magee, Anthony I.; Seabra, Miguel C.. "Rab GTPases Containing a CAAXMotif Are
Processed Post-geranylgeranylation by Proteolysis and Methylation". Journal of Biological Chemistry 282 2 (2006): 1487-1497.
http://dx.doi.org/10.1074/jbc.m605557200.
Acesso aberto • Publicado • 10.1074/jbc.m605557200
- Hume, Alistair N.; Tarafder, Abul K.; Ramalho, José S.; Sviderskaya, Elena V.; Seabra, Miguel C.. "A Coiled-Coil Domain of
Melanophilin Is Essential for Myosin Va Recruitment and Melanosome Transport in Melanocytes". Molecular Biology of the
Cell 17 11 (2006): 4720-4735. http://dx.doi.org/10.1091/mbc.e06-05-0457.
Acesso aberto • Publicado • 10.1091/mbc.e06-05-0457
- Wasmeier, Christina; Romao, Maryse; Plowright, Lynn; Bennett, Dorothy C.; Raposo, Grac¸a; Seabra, Miguel C.. "Rab38 and Rab32
control post-Golgi trafficking of melanogenic enzymes". Journal of Cell Biology 175 2 (2006): 271-281. http://dx.doi.org/10.1083/jcb.200606050.
Acesso aberto • Publicado • 10.1083/jcb.200606050
- Savina, Ariel; Jancic, Carolina; Hugues, Stephanie; Guermonprez, Pierre; Vargas, Pablo; Moura, Ivan Cruz; Lennon-Duménil,
Ana-Maria; et al. "NOX2 Controls Phagosomal pH to Regulate Antigen Processing during Crosspresentation by Dendritic Cells".
Cell 126 1 (2006): 205-218. http://dx.doi.org/10.1016/j.cell.2006.05.035.
Acesso aberto • Publicado • 10.1016/j.cell.2006.05.035
- Tolmachova, T.. "Independent degeneration of photoreceptors and retinal pigment epithelium in conditional knockout mouse models
of choroideremia". Journal of Clinical Investigation 116 2 (2006): 386-394. http://dx.doi.org/10.1172/jci26617.
Acesso aberto • Publicado • 10.1172/jci26617
- Leung, Ka Fai; Baron, Rudi; Seabra, Miguel C.. "Thematic review series: Lipid Posttranslational Modifications.Geranylgeranylation
of Rab GTPases". Journal of Lipid Research 47 3 (2006): 467-475. http://dx.doi.org/10.1194/jlr.r500017-jlr200.
Acesso aberto • 10.1194/jlr.r500017-jlr200
- "A coiled-coil domain of melanophilin is essential for Myosin Va recruitment and melanosome transport in melanocytes". Molecular
biology of the cell (2006): http://europepmc.org/articles/PMC1635380.
10.1091/mbc.E06-05-0457
- "Independent degeneration of photoreceptors and retinal pigment epithelium in conditional knockout mouse models of choroideremia".
The Journal of clinical investigation (2006): http://europepmc.org/articles/PMC1326146.
10.1172/JCI26617
- Johnson, Jennifer L.; Ellis, Beverly A.; Noack, Deborah; Seabra, Miguel C.; Catz, Sergio D.. "The Rab27a-binding protein,
JFC1, regulates androgen-dependent secretion of prostate-specific antigen and prostatic-specific acid phosphatase1". Biochemical
Journal 391 3 (2005): 699-710. http://dx.doi.org/10.1042/bj20050380.
Acesso aberto • Publicado • 10.1042/bj20050380
- Coxon, Fraser P.; Ebetino, Frank H.; Mules, Emilie H.; Seabra, Miguel C.; McKenna, Charles E.; Rogers, Michael J.. "Phosphonocarboxylate
inhibitors of Rab geranylgeranyl transferase disrupt the prenylation and membrane localization of Rab proteins in osteoclasts
in vitro and in vivo". Bone 37 3 (2005): 349-358. http://dx.doi.org/10.1016/j.bone.2005.04.021.
Publicado • 10.1016/j.bone.2005.04.021
- Ali, B.R.; Seabra, M.C.. "Targeting of Rab GTPases to cellular membranes". Biochemical Society Transactions 33 4 (2005):
652-656. http://dx.doi.org/10.1042/bst0330652.
Publicado • 10.1042/bst0330652
- Chen, Ying; Bellamy, William P.; Seabra, Miguel C.; Field, Mark C.; Ali, Bassam R.. "ER-associated protein degradation is
a common mechanism underpinning numerous monogenic diseases including Robinow syndrome". Human Molecular Genetics 14
17 (2005): 2559-2569. http://dx.doi.org/10.1093/hmg/ddi259.
Publicado • 10.1093/hmg/ddi259
- Magee, Tony; Seabra, Miguel C. "Fatty acylation and prenylation of proteins: what's hot in fat". Current Opinion in Cell
Biology 17 2 (2005): 190-196. http://dx.doi.org/10.1016/j.ceb.2005.02.003.
Publicado • 10.1016/j.ceb.2005.02.003
- "The Rab27a-binding protein, JFC1, regulates androgen-dependent secretion of prostate-specific antigen and prostatic-specific
acid phosphatase". The Biochemical journal (2005): http://europepmc.org/articles/PMC1276972.
10.1042/BJ20050380
- Ali, B. R.. "Multiple regions contribute to membrane targeting of Rab GTPases". Journal of Cell Science 117 26 (2004):
6401-6412. http://dx.doi.org/10.1242/jcs.01542.
Acesso aberto • Publicado • 10.1242/jcs.01542
- Westbroek, Wendy; Lambert, Jo; Schepper, Sofie De; Kleta, Robert; Bossche, Karolien Van Den; Seabra, Miguel C.; Huizing, Marjan;
Mommaas, Mieke; Naeyaert, Jean Marie. "Rab27b is Up-Regulated in Human Griscelli Syndrome Type II Melanocytes and Linked to
the Actin Cytoskeleton via Exon F-Myosin Va Transcripts". Pigment Cell Research 17 5 (2004): 498-505. http://dx.doi.org/10.1111/j.1600-0749.2004.00173.x.
Publicado • 10.1111/j.1600-0749.2004.00173.x
- Seabra, Miguel C; Wasmeier, Christina. "Controlling the location and activation of Rab GTPases". Current Opinion in Cell
Biology 16 4 (2004): 451-457. http://dx.doi.org/10.1016/j.ceb.2004.06.014.
Publicado • 10.1016/j.ceb.2004.06.014
- Futter, Clare E.; Ramalho, José S.; Jaissle, Gesine B.; Seeliger, Mathias W.; Seabra, Miguel C.. "The Role of Rab27a in the
Regulation of Melanosome Distribution within Retinal Pigment Epithelial Cells". Molecular Biology of the Cell 15 5
(2004): 2264-2275. http://dx.doi.org/10.1091/mbc.e03-10-0772.
Acesso aberto • Publicado • 10.1091/mbc.e03-10-0772
- Seabra, Miguel C.; Coudrier, Evelyne. "Rab GTPases and Myosin Motors in Organelle Motility". Traffic 5 6 (2004): 393-399.
http://dx.doi.org/10.1111/j.1398-9219.2004.00190.x.
Acesso aberto • Publicado • 10.1111/j.1398-9219.2004.00190.x
- Barral, Duarte C.; Seabra, Miguel C.. "The Melanosome as a Model to Study Organelle Motility in Mammals". Pigment Cell
Research 17 2 (2004): 111-118. http://dx.doi.org/10.1111/j.1600-0749.2004.00138.x.
Publicado • 10.1111/j.1600-0749.2004.00138.x
- Ramalho, J S. "Mouse genetic corneal disease resulting from transgenic insertional mutagenesis". British Journal of Ophthalmology
88 3 (2004): 428-432. http://dx.doi.org/10.1136/bjo.2003.028787.
Acesso aberto • 10.1136/bjo.2003.028787
- Tolmachova, Tanya; Anders, Ross; Stinchcombe, Jane; Bossi, Giovanna; Griffiths, Gillian M.; Huxley, Clare; Seabra, Miguel
C.. "A General Role for Rab27a in Secretory Cells". Molecular Biology of the Cell 15 1 (2004): 332-344. http://dx.doi.org/10.1091/mbc.e03-07-0452.
Acesso aberto • Publicado • 10.1091/mbc.e03-07-0452
- "A general role for Rab27a in secretory cells". Molecular biology of the cell (2004): http://europepmc.org/articles/PMC307551.
10.1091/mbc.E03-07-0452
- "The role of Rab27a in the regulation of melanosome distribution within retinal pigment epithelial cells". Molecular biology
of the cell (2004): http://europepmc.org/articles/PMC404021.
10.1091/mbc.E03-10-0772
- Marques, MPM; Miranda, MA; Pereira, E; de Lima, MCP; da Cruz, MTG; Reis, E; Seabra, M; Teixeira, LJ. "Cytotoxic activity of
metal complexes of biogenic polyamines: Polynuclear platinum(II) chelates". Journal of Medicinal Chemistry (2004):
https://publons.com/publon/6017759/.
10.1021/JM0311238
- Tiwari, Sanjay; Italiano, Joseph E.; Barral, Duarte C.; Mules, Emilie H.; Novak, Edward K.; Swank, Richard T.; Seabra, Miguel
C.; Shivdasani, Ramesh A.. "A role for Rab27b in NF-E2-dependent pathways of platelet formation". Blood 102 12 (2003):
3970-3979. http://dx.doi.org/10.1182/blood-2003-03-0977.
Publicado • 10.1182/blood-2003-03-0977
- MAGEE, Anthony I.; SEABRA, Miguel C.. "Are prenyl groups on proteins sticky fingers or greasy handles?". Biochemical Journal
376 1 (2003): e3-e4. http://dx.doi.org/10.1042/bj20031531.
Acesso aberto • Publicado • 10.1042/bj20031531
- Hannah, M. J.. "Weibel-Palade bodies recruit Rab27 by a content-driven, maturation-dependent mechanism that is independent
of cell type". Journal of Cell Science 116 19 (2003): 3939-3948. http://dx.doi.org/10.1242/jcs.00711.
Acesso aberto • Publicado • 10.1242/jcs.00711
- Larijani, Banafshé; Hume, Alistair N.; Tarafder, Abul K.; Seabra, Miguel C.. "Multiple Factors Contribute to Inefficient Prenylation
of Rab27a in Rab Prenylation Diseases". Journal of Biological Chemistry 278 47 (2003): 46798-46804. http://dx.doi.org/10.1074/jbc.m307799200.
Acesso aberto • Publicado • 10.1074/jbc.m307799200
- Gomes, Anita Q.; Ali, Bassam R.; Ramalho, José S.; Godfrey, Richard F.; Barral, Duarte C.; Hume, Alistair N.; Seabra, Miguel
C.. "Membrane Targeting of Rab GTPases Is Influenced by the Prenylation Motif". Molecular Biology of the Cell 14 5
(2003): 1882-1899. http://dx.doi.org/10.1091/mbc.e02-10-0639.
Acesso aberto • Publicado • 10.1091/mbc.e02-10-0639
- Gomes, Anita Q.; Ali, Bassam R.; Ramalho, José S.; Godfrey, Richard F.; Barral, Duarte C.; Hume, Alistair N.; Seabra, Miguel
C.. "Membrane Targeting of Rab GTPases Is Influenced by the Prenylation Motif". Molecular Biology of the Cell 14 5
(2003): 1882-1899. http://dx.doi.org/10.1091/mbc.e02-10-0639.
Acesso aberto • Publicado • 10.1091/mbc.e02-10-0639
- Anand, Vibha; Barral, Duarte C; Zeng, Yong; Brunsmann, Frank; Maguire, Albert M; Seabra, Miguel C; Bennett, Jean. "Gene therapy
for choroideremia: in vitro rescue mediated by recombinant adenovirus". Vision Research 43 8 (2003): 919-926. http://dx.doi.org/10.1016/s0042-6989(02)00389-9.
Acesso aberto • 10.1016/s0042-6989(02)00389-9
- Pereira-Leal, José B.; Strom, Molly; Godfrey, Richard F.; Seabra, Miguel C.. "Structural determinants of Rab and Rab Escort
Protein interaction: Rab family motifs define a conserved binding surface". Biochemical and Biophysical Research Communications
301 1 (2003): 92-97. http://dx.doi.org/10.1016/s0006-291x(02)02963-7.
Publicado • 10.1016/s0006-291x(02)02963-7
- "Are prenyl groups on proteins sticky fingers or greasy handles?". The Biochemical journal (2003): http://europepmc.org/articles/PMC1223795.
10.1042/BJ20031531
- "Membrane targeting of Rab GTPases is influenced by the prenylation motif". Molecular biology of the cell (2003): http://europepmc.org/articles/PMC165084.
10.1091/mbc.E02-10-0639
- Barral, D. C.. "Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome". Journal of Clinical
Investigation 110 8 (2002): 1213-1213. http://dx.doi.org/10.1172/jci200215058e.
Acesso aberto • Publicado • 10.1172/jci200215058e
- Strom, Molly; Hume, Alistair N.; Tarafder, Abul K.; Barkagianni, Eleni; Seabra, Miguel C.. "A Family of Rab27-binding Proteins".
Journal of Biological Chemistry 277 28 (2002): 25423-25430. http://dx.doi.org/10.1074/jbc.m202574200.
Acesso aberto • Publicado • 10.1074/jbc.m202574200
- Hume, Alistair N.; Collinson, Lucy M.; Hopkins, Colin R.; Strom, Molly; Barral, Duarte C.; Bossi, Giovanna; Griffiths, Gillian
M.; Seabra, Miguel C.. "The leaden Gene Product Is Required with Rab27a to Recruit Myosin Va to Melanosomes in Melanocytes".
Traffic 3 3 (2002): 193-202. http://dx.doi.org/10.1034/j.1600-0854.2002.030305.x.
Acesso aberto • Publicado • 10.1034/j.1600-0854.2002.030305.x
- Seabra, Miguel C; Mules, Emilie H; Hume, Alistair N. "Rab GTPases, intracellular traffic and disease". Trends in Molecular
Medicine 8 1 (2002): 23-30. http://dx.doi.org/10.1016/s1471-4914(01)02227-4.
10.1016/s1471-4914(01)02227-4
- Pereira-Leal JB; Gomes AQ; Seabra MC. "Analysis and preparation of stable complexes between Rab GTPases, Rab escort protein,
and Rab geranylgeranyl transferase.". (2002): http://europepmc.org/abstract/med/12094584.
- Ramalho, José S; Anders, Ross; Jaissle, Gesine B; Seeliger, Mathias W; Huxley, Clare; Seabra, Miguel C. "BMC Cell Biology".
BMC Cell Biology 3 1 (2002): 26. http://dx.doi.org/10.1186/1471-2121-3-26.
Acesso aberto • Publicado • 10.1186/1471-2121-3-26
- "Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome". The Journal of clinical investigation
(2002): http://europepmc.org/articles/PMC150811.
10.1172/JCI0215058
- Pereira-Leal, José B.; Seabra, Miguel C.. "Evolution of the rab family of small GTP-binding proteins". Journal of Molecular
Biology 313 4 (2001): 889-901. http://dx.doi.org/10.1006/jmbi.2001.5072.
Publicado • 10.1006/jmbi.2001.5072
- Coxon, Fraser P.; Helfrich, Miep H.; Larijani, Banafshe; Muzylak, Mariusz; Dunford, James E.; Marshall, Deborah; McKinnon,
Alastair D.; et al. "Identification of a Novel Phosphonocarboxylate Inhibitor of Rab Geranylgeranyl Transferase That Specifically
Prevents Rab Prenylation in Osteoclasts and Macrophages". Journal of Biological Chemistry 276 51 (2001): 48213-48222.
http://dx.doi.org/10.1074/jbc.m106473200.
Acesso aberto • Publicado • 10.1074/jbc.m106473200
- Marks, Michael S.; Seabra, Miguel C.. "The melanosome: membrane dynamics in black and white". Nature Reviews Molecular
Cell Biology 2 10 (2001): 738-748. http://dx.doi.org/10.1038/35096009.
10.1038/35096009
- Pereira-Leal, José B; Hume, Alistair N; Seabra, Miguel C. "Prenylation of Rab GTPases: molecular mechanisms and involvement
in genetic disease". FEBS Letters 498 2-3 (2001): 197-200. http://dx.doi.org/10.1016/s0014-5793(01)02483-8.
10.1016/s0014-5793(01)02483-8
- Syed, Nasreen; Smith, Julie E; John, Sinoj K; Seabra, Miguel C; Aguirre, Gustavo D; Milam, Ann H. "Evaluation of retinal photoreceptors
and pigment epithelium in a female carrier of choroideremia". Ophthalmology 108 4 (2001): 711-720. http://dx.doi.org/10.1016/s0161-6420(00)00643-6.
Publicado • 10.1016/s0161-6420(00)00643-6
- Hume, Alistair N.; Collinson, Lucy M.; Rapak, Andrzej; Gomes, Anita Q.; Hopkins, Colin R.; Seabra, Miguel C.. "Rab27a Regulates
the Peripheral Distribution of Melanosomes in Melanocytes". Journal of Cell Biology 152 4 (2001): 795-808. http://dx.doi.org/10.1083/jcb.152.4.795.
Acesso aberto • Publicado • 10.1083/jcb.152.4.795
- Stinchcombe, Jane C.; Barral, Duarte C.; Mules, Emilie H.; Booth, Sarah; Hume, Alistair N.; Machesky, Laura M.; Seabra, Miguel
C.; Griffiths, Gillian M.. "Rab27a Is Required for Regulated Secretion in Cytotoxic T Lymphocytes". Journal of Cell Biology
152 4 (2001): 825-834. http://dx.doi.org/10.1083/jcb.152.4.825.
Acesso aberto • Publicado • 10.1083/jcb.152.4.825
- Ramalho, José S; Tolmachova, Tanya; Hume, Alistair N; McGuigan, Amanda; Gregory-Evans, Cheryl Y; Huxley, Clare; Seabra, Miguel
C. "BMC Genetics". BMC Genetics 2 1 (2001): 2. http://dx.doi.org/10.1186/1471-2156-2-2.
Acesso aberto • 10.1186/1471-2156-2-2
- Miguel C Seabra. "Identification of a phosphonocarboxylate analogue of risedronate which inhibits geranylgeranyl transferase
II and selectively prevents prenylation of Rab proteins in osteoclasts". Bone (2001): https://publons.com/publon/12022269/.
- "Identification of a novel phosphonocarboxylate inhibitor of Rab geranylgeranyl transferase that specifically prevents Rab
prenylation in osteoclasts and macrophages". The Journal of biological chemistry (2001): http://intl.jbc.org/cgi/content/full/276/51/48213.
10.1074/JBC.M106473200
- Ramalho, J.S.; Tolmachova, T.; Hume, A.N.; McGuigan, A.; Gregory-Evans, C.Y.; Huxley, C.; Seabra, M.C.. "Chromosomal mapping,
gene structure and characterization of the human and murine RAB27B gene.". BMC genetics [electronic resource] 2 1 (2001):
http://www.scopus.com/inward/record.url?eid=2-s2.0-18744416632&partnerID=MN8TOARS.
- Bergo, Martin O.; Leung, Gordon K.; Ambroziak, Patricia; Otto, James C.; Casey, Patrick J.; Gomes, Anita Q.; Seabra, Miguel
C.; Young, Stephen G.. "Isoprenylcysteine Carboxyl Methyltransferase Deficiency in Mice". Journal of Biological Chemistry
276 8 (2000): 5841-5845. http://dx.doi.org/10.1074/jbc.c000831200.
Acesso aberto • Publicado • 10.1074/jbc.c000831200
- Pereira-Leal, José B; Seabra, Miguel C. "The mammalian Rab family of small GTPases: definition of family and subfamily sequence
motifs suggests a mechanism for functional specificity in the Ras superfamily 1 1Edited by M. Yaniv". Journal of Molecular
Biology 301 4 (2000): 1077-1087. http://dx.doi.org/10.1006/jmbi.2000.4010.
Publicado • 10.1006/jmbi.2000.4010
- Detter, J. C.; Zhang, Q.; Mules, E. H.; Novak, E. K.; Mishra, V. S.; Li, W.; McMurtrie, E. B.; et al. "Rab geranylgeranyl
transferase alpha mutation in the gunmetal mouse reduces Rab prenylation and platelet synthesis". Proceedings of the National
Academy of Sciences 97 8 (2000): 4144-4149. http://dx.doi.org/10.1073/pnas.080517697.
Acesso aberto • Publicado • 10.1073/pnas.080517697
- Zhang, Hong; Seabra, Miguel C; Deisenhofer, Johann. "Crystal structure of Rab geranylgeranyltransferase at 2.0 Å resolution".
Structure 8 3 (2000): 241-251. http://dx.doi.org/10.1016/s0969-2126(00)00102-7.
Acesso aberto • 10.1016/s0969-2126(00)00102-7
- Tolmachova, Tanya; Ramalho, José S.; Anant, Janmeet S.; Schultz, Roger A.; Huxley, Clare M.; Seabra, Miguel C.. "Cloning,
mapping and characterization of the human RAB27A gene". Gene 239 1 (1999): 109-116. http://dx.doi.org/10.1016/s0378-1119(99)00371-6.
10.1016/s0378-1119(99)00371-6
- Desnoyers, L.; Seabra, M. C.. "Single prenyl-binding site on protein prenyl transferases". Proceedings of the National
Academy of Sciences 95 21 (1998): 12266-12270. http://dx.doi.org/10.1073/pnas.95.21.12266.
Acesso aberto • Publicado • 10.1073/pnas.95.21.12266
- MacDonald, I. "A practical diagnostic test for choroideremia". Ophthalmology 105 9 (1998): 1637-1640. http://dx.doi.org/10.1016/s0161-6420(98)99031-5.
Publicado • 10.1016/s0161-6420(98)99031-5
- Anant, Janmeet S.; Desnoyers, Luc; Machius, Mischa; Demeler, Borries; Hansen, Jeffrey C.; Westover, Kenneth D.; Deisenhofer,
Johann; Seabra, Miguel C.. "Mechanism of Rab Geranylgeranylation: Formation of the Catalytic Ternary Complex†". Biochemistry
37 36 (1998): 12559-12568. http://dx.doi.org/10.1021/bi980881a.
Acesso aberto • 10.1021/bi980881a
- Seabra, M.C.; Seabra, Miguel. "Membrane association and targeting of prenylated Ras-like GTPases". Cellular Signalling
10 3 (1998): 167-172. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031970317&partnerID=MN8TOARS.
10.1016/S0898-6568(97)00120-4
- "Single prenyl-binding site on protein prenyl transferases". Proceedings of the National Academy of Sciences of the United
States of America (1998): http://europepmc.org/articles/PMC22820.
10.1073/PNAS.95.21.12266
- Bokhoven, Hans Van; Rawson, Robert B.; Merkx, Gerard F.M.; Cremers, Frans P.M.; Seabra, Miguel C.. "cDNA Cloning and Chromosomal
Localization of the Genes Encoding the a- and ß-Subunits of Human Rab Geranylgeranyl Transferase: The 3' End of the a-Subunit
Gene Overlaps with the Transglutaminase 1 Gene Promoter". Genomics 38 2 (1996): 133-140. http://dx.doi.org/10.1006/geno.1996.0608.
10.1006/geno.1996.0608
- Rybin, Vladimir; Ullrich, Oliver; Rubino, Mariantonietta; Alexandrov, Kirill; Simon, Iris; Seabra, Miguel C.; Goody, Roger;
Zerial, Marino. "GTPase activity of Rab5 acts as a timer for endocytic membrane fusion". Nature 383 6597 (1996): 266-269.
http://dx.doi.org/10.1038/383266a0.
Publicado • 10.1038/383266a0
- Desnoyers, L.; Anant, J. S.; Seabra, M. C.. "Geranylgeranylation of Rab proteins". Biochemical Society Transactions
24 3 (1996): 699-703. http://dx.doi.org/10.1042/bst0240699.
Publicado • 10.1042/bst0240699
- Seabra, Miguel C.. "Nucleotide Dependence of Rab Geranylgeranylation". Journal of Biological Chemistry 271 24 (1996):
14398-14404. http://dx.doi.org/10.1074/jbc.271.24.14398.
Acesso aberto • Publicado • 10.1074/jbc.271.24.14398
- Casey, Patrick J.; Seabra, Miguel C.. "Protein Prenyltransferases". Journal of Biological Chemistry 271 10 (1996):
5289-5292. http://dx.doi.org/10.1074/jbc.271.10.5289.
Acesso aberto • Publicado • 10.1074/jbc.271.10.5289
- Wyne, Kathleen L.; Pathak, Ravindra K.; Seabra, Miguel C.; Hobbs, Helen H.. "Expression of the VLDL Receptor in Endothelial
Cells". Arteriosclerosis, Thrombosis, and Vascular Biology 16 3 (1996): 407-415. http://dx.doi.org/10.1161/01.atv.16.3.407.
Acesso aberto • 10.1161/01.atv.16.3.407
- Shen, Fang; Seabra, Miguel C.. "Mechanism of Digeranylgeranylation of Rab Proteins". Journal of Biological Chemistry
271 7 (1996): 3692-3698. http://dx.doi.org/10.1074/jbc.271.7.3692.
Acesso aberto • Publicado • 10.1074/jbc.271.7.3692
- Mooser, V; Seabra, M C; Abedin, M; Landschulz, K T; Marcovina, S; Hobbs, H H. "Apolipoprotein(a) kringle 4-containing fragments
in human urine. Relationship to plasma levels of lipoprotein(a).". Journal of Clinical Investigation 97 3 (1996): 858-864.
http://dx.doi.org/10.1172/jci118487.
Acesso aberto • Publicado • 10.1172/jci118487
- Seabra, Miguel C.. "New insights into the pathogenesis of choroideremia: a tale of two REPs". Ophthalmic Genetics 17
2 (1996): 43-46. http://dx.doi.org/10.3109/13816819609057869.
Acesso aberto • 10.3109/13816819609057869
- Seabra, MC. "Nucleotide dependence of Rab geranylgeranylation - Rab escort protein interacts preferentially with GDP-bound
Rab". Journal of Biological Chemistry (1996): https://publons.com/publon/11687801/.
10.1074/JBC.271.24.14398
- Seabra, MC; Shen, F. "Mechanism of digeranylgeranylation of rab proteins - Formation of a complex between monogeranylgeranyl-rab
and rab escort protein". Journal of Biological Chemistry (1996): https://publons.com/publon/11687808/.
- Seabra, MC; Cremers, FPM; Merkx, GFM; Rawson, RB; vanBokhoven, H. "cDNA cloning and chromosomal localization of the genes
encoding the alpha- and beta-subunits of human Rab geranylgeranyl transferase: 3' end of the alpha-subunit gene overlaps with
the transglutaminase 1 gene promoter". Genomics (1996): https://publons.com/publon/11687795/.
- Seabra, M.C.. "New insights into the pathogenesis of choroideremia: a tale of two REPs.". Ophthalmic genetics 17 2
(1996): 43-46. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030158607&partnerID=MN8TOARS.
- Shen, F.; Seabra, M.C.. "Mechanism of digeranylgeranylation of rab proteins: Formation of a complex between Monogeranylgeranyl-Rab
and Rab escort protein". Journal of Biological Chemistry 271 7 (1996): 3692-3698. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030051303&partnerID=MN8TOARS.
- Mooser, V.; Seabra, M.C.; Abedin, M.; Landschulz, K.T.; Marcovina, S.; Hobbs, H.H.. "Apolipoprotein(a) kringle 4-containing
fragments in human urine: Relationship to plasma levels of lipoprotein(a)". Journal of Clinical Investigation 97 3
(1996): 858-864. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030027648&partnerID=MN8TOARS.
- Zerial, M; Goody, R; Seabra, M; Alexandrov, K; Ullrich, O; Rybin, V; Rubino, M. "GTPase activity of RAB5 as a timer for endocytic
membrane fusion". Molecular Biology of the Cell (1996): https://publons.com/publon/10407425/.
- Seabra, M.C.. "Nucleotide dependence of rab geranylgeranylation rab escort protein interacts preferentially with GDP-bound
Rab". Journal of Biological Chemistry 271 24 (1996): 14398-14404. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030010536&partnerID=MN8TOARS.
- Seabra, Miguel C.; Ho, Yiu K.; Anant, Janmeet S.. "Deficient Geranylgeranylation of Ram/Rab27 in Choroideremia". Journal
of Biological Chemistry 270 41 (1995): 24420-24427. http://dx.doi.org/10.1074/jbc.270.41.24420.
Acesso aberto • Publicado • 10.1074/jbc.270.41.24420
- S A Armstrong; M S Brown; J L Goldstein; Seabra, Miguel C.. "Preparation of recombinant Rab geranylgeranyltransferase and
Rab escort proteins". Methods in Enzymology 257 (1995): 30-41. http://dx.doi.org/10.1074/jbc.271.24.14398.
Publicado
- Farnsworth, C. C.; Seabra, M. C.; Ericsson, L. H.; Gelb, M. H.; Glomset, J. A.. "Rab geranylgeranyl transferase catalyzes
the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A.". Proceedings of the National
Academy of Sciences 91 25 (1994): 11963-11967. http://dx.doi.org/10.1073/pnas.91.25.11963.
Acesso aberto • Publicado • 10.1073/pnas.91.25.11963
- Alexandrov, K.; Horiuchi, H.; Steele-Mortimer, O.; Seabra, M.C.; Zerial, M.. "Rab escort protein-1 is a multifunctional protein
that accompanies newly prenylated rab proteins to their target membranes.". The EMBO Journal 13 22 (1994): 5262-5273.
http://dx.doi.org/10.1002/j.1460-2075.1994.tb06860.x.
Acesso aberto • 10.1002/j.1460-2075.1994.tb06860.x
- Smeland, T. E.; Seabra, M. C.; Goldstein, J. L.; Brown, M. S.. "Geranylgeranylated Rab proteins terminating in Cys-Ala-Cys,
but not Cys-Cys, are carboxyl-methylated by bovine brain membranes in vitro.". Proceedings of the National Academy of Sciences
91 22 (1994): 10712-10716. http://dx.doi.org/10.1073/pnas.91.22.10712.
Publicado • 10.1073/pnas.91.22.10712
- Seabra, Miguel. "REP-2, a Rab escort protein encoded by the choroideremia-like gene". The Journal of biological chemistry
(1994): http://europepmc.org/abstract/MED/8294464.
Acesso aberto
- Seabra, M.; Brown, M.; Goldstein, J.. "Retinal degeneration in choroideremia: deficiency of rab geranylgeranyl transferase".
Science 259 5093 (1993): 377-381. http://dx.doi.org/10.1126/science.8380507.
10.1126/science.8380507
- Seabra, Miguel. "cDNA cloning of component A of Rab geranylgeranyl transferase and demonstration of its role as a Rab escort
protein". Cell (1993): https://doi.org/10.1016/0092-8674(93)90639-8.
10.1016/0092-8674(93)90639-8
- Armstrong, S.A.; Seabra, M.C.; Südhof, T.C.; Goldstein, J.L.; Brown, M.S.. "cDNA cloning and expression of the a and ß subunits
of rat rab geranylgeranyl transferase". Journal of Biological Chemistry 268 16 (1993): 12221-12229. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027298707&partnerID=MN8TOARS.
Acesso aberto
- BROWN, MS; GOLDSTEIN, JL; SUDHOF, TC; SEABRA, MC; ARMSTRONG, SA. "CDNA CLONING AND EXPRESSION OF THE ALPHA-SUBUNIT AND BETA-SUBUNIT
OF RAT RAB GERANYLGERANYL TRANSFERASE". FASEB Journal (1993): https://publons.com/publon/11687821/.
- Seabra, Miguel C.; Brown, Michael S.; Slaughter, Clive A.; Südhof, Thomas C.; Goldstein, Joseph L.. "Purification of component
A of Rab geranylgeranyl transferase: Possible identity with the choroideremia gene product". Cell 70 6 (1992): 1049-1057.
http://dx.doi.org/10.1016/0092-8674(92)90253-9.
Publicado • 10.1016/0092-8674(92)90253-9
- Miguel C. Seabra; J L Goldstein; T C Südhof; M S Brown. "Rab geranylgeranyl transferase. A multisubunit enzyme that prenylates
GTP-binding proteins terminating in Cys-X-Cys or Cys-Cys". Journal of Biological Chemistry 267 20 (1992): 14497-14503.
https://www.jbc.org/content/267/20/14497.long.
Acesso aberto • Publicado
- Reiss, Y.; Seabra, M. C.; Brown, M. S.; Goldstein, J. L.. "p21ras Farnesyltransferase: purification and properties of the
enzyme". Biochemical Society Transactions 20 2 (1992): 487-488. http://dx.doi.org/10.1042/bst0200487.
Publicado • 10.1042/bst0200487
- Seabra, M.C.; Goldstein, J.L.; Südhof, T.C.; Brown, M.S.. "Rab geranylgeranyl transferase: A multisubunit enzyme that prenylates
GTP-binding proteins terminating in Cys-X-Cys or Cys-Cys". Journal of Biological Chemistry 267 20 (1992): 14497-14503.
http://www.scopus.com/inward/record.url?eid=2-s2.0-0026629308&partnerID=MN8TOARS.
Acesso aberto
- GOLDSTEIN, JL; BROWN, MS; SEABRA, MC; REISS, Y. "P21RAS FARNESYLTRANSFERASE - PURIFICATION AND PROPERTIES OF THE ENZYME".
Biochemical Society Transactions (1992): https://publons.com/publon/11687817/.
10.1042/BST0200487
- BROWN, MS; SUDHOF, TC; GOLDSTEIN, JL; SEABRA, MC. "RAB GERANYLGERANYL TRANSFERASE - A MULTISUBUNIT ENZYME THAT PRENYLATES
GTP-BINDING PROTEINS TERMINATING IN CYS-X-CYS OR CYS-CYS". Journal of Biological Chemistry (1992): https://publons.com/publon/11687818/.
- Seabra, Miguel C.; Reiss, Yuval; Casey, Patrick J.; Brown, Michael S.; Goldstein, Joseph L.. "Protein farnesyltransferase
and geranylgeranyltransferase share a common a subunit". Cell 65 3 (1991): 429-434. http://dx.doi.org/10.1016/0092-8674(91)90460-g.
Publicado • 10.1016/0092-8674(91)90460-g
- Reiss, Y.; Seabra, M.C.; Armstrong, S.A.; Slaughter, C.A.; Goldstein, J.L.; Brown, M.S.. "Nonidentical subunits of p21H-ras
farnesyltransferase: Peptide binding and farnesyl pyrophosphate carrier functions". Journal of Biological Chemistry
266 16 (1991): 10672-10677. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025923649&partnerID=MN8TOARS.
Acesso aberto
- Seabra, M.C.; Reiss, Y.; Casey, P.J.; Brown, M.S.; Goldstein, J.L.. "Protein farnesyltransferase and geranylgeranyltransferase
share a common a subunit". Cell 65 3 (1991): 429-434. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025819073&partnerID=MN8TOARS.
10.1016/0092-8674(91)90460-G
- BROWN, MS; GOLDSTEIN, JL; SLAUGHTER, CA; ARMSTRONG, SA; SEABRA, MC; REISS, Y. "NONIDENTICAL SUBUNITS OF P21H-RAS FARNESYLTRANSFERASE
- PEPTIDE BINDING AND FARNESYL PYROPHOSPHATE CARRIER FUNCTIONS". Journal of Biological Chemistry (1991): https://publons.com/publon/11687816/.
- REISS, Y; SEABRA, M; GOLDSTEIN, J; BROWN, M. "Purification of ras farnesyl:Protein transferase". Methods 1 3 (1990):
241-245. http://dx.doi.org/10.1016/s1046-2023(05)80323-8.
10.1016/s1046-2023(05)80323-8
- Reiss, Yuval; Goldstein, Joseph L.; Seabra, Miguel C.; Casey, Patrick J.; Brown, Michael S.. "Inhibition of purified p21ras
farnesyl:protein transferase by Cys-AAX tetrapeptides". Cell 62 1 (1990): 81-88. http://dx.doi.org/10.1016/0092-8674(90)90242-7.
Publicado • 10.1016/0092-8674(90)90242-7
- Reiss, Y.; Seabra, M.C.; Goldstein, J.L.; Brown, M.S.. "Purification of ras farnesyl:Protein transferase". Methods
1 3 (1990): 241-245. http://www.scopus.com/inward/record.url?eid=2-s2.0-0000504764&partnerID=MN8TOARS.
- Mesquita, M F; Seabra, M P; Halpern, M J. "Simple carbohydrates in the diet". The American Journal of Clinical Nutrition
45 5 (1987): 1197-1201. http://dx.doi.org/10.1093/ajcn/45.5.1197.
Publicado • 10.1093/ajcn/45.5.1197
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Resumo em conferência |
- "Impairement of chorioretinal vasculature in patients with intermediate age-related macular degeneration.". Trabalho apresentado
em ARVO Annual Meeting - Investigative Ophthalmology & Visual Science, 2021.
- "Formation of lipofuscin-like autofluorescent granules in the retinal pigment epithelium requires lysosome dysfunction". Trabalho
apresentado em ARVO Annual Meeting - Investigative Ophthalmology & Visual Science, 2021.
- "Effects of a-synuclein overexpression in retinal degeneration: a 3D organoid approach". Trabalho apresentado em Cell Bio
Virtual - ASCB/EMBO Online Meeting, 2021.
- "Modelling retinal degenerative mechanisms using patient-derived organoids". Trabalho apresentado em 3rd NMS Symposium,
2021.
- "Modeling retinal degeneration by hyperglycemia using 3D human organoids". Trabalho apresentado em Organoids With]Out[
Borders - Online Symposium, 2020.
- "Modeling retinal degeneration by hyperglycemia and oxidative stress using 3D human organoids". Trabalho apresentado em EMBO|EMBL
Symposium: Organoids: Modeling Organ development and disease in 3D cell culture-virtual, 2020.
- Flores, Rita; Ana Luisa Basilio; Nuno Moura-Coelho; Margarida Marques; Luisa Vieira; Joana Cardigos; Ines Fragoeiro; et al.
"Novel disease progression biomarkers in non-exudative age-related macular degeneration: an association study between drusen
type and morphology and Fundus Autofluorescence". Trabalho apresentado em ARVO Annual Meeting, Vancouver, 2019.
Publicado
- Miguel C. Seabra; M. Helena Cardoso; Michael Hall; A. Sofia Falcão; Cristina Escrevente; Pedro Antas; Gabriela V. Santos;
Tenreiro, Sandra; Clare E. Futter. "Modeling lysosomal dysfunction in the retinal pigmented epithelium to study pathogenesis
of age-related macular degeneration". Trabalho apresentado em ARVO Annual Meeting, Vancouver, 2019.
Publicado
- Tarafder, A. K.; Pereira, F. J.; Correia, M. S.; Barral, D. C.; Seabra, M. C.. "Mechanisms of melanin transfer from melanocytes
and formation of a parasol in keratinocytes". 2016.
- MacLaren, Robert; Seabra, Miguel; Simunovic, Matthew; Downes, Susan; Xue, Kanmin; Holder, Graham; Lotery, Andrew; et al. "SUSTAINED
IMPROVEMENT IN VISUAL ACUITY AFTER RETINAL GENE THERAPY FOR CHOROIDEREMIA". 2016.
- Seabra, Miguel. "Long term vision results following retinal gene therapy for choroideremia". Trabalho apresentado em Annual
Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), 2016.
- Seabra, Miguel C.; Futter, Clare E.; Feleciano, Diogo A.; Tolmachova, Tanya. "Middle age-associated lysosomal upregulation
in the healthy mouse retinal pigment epithelium". Trabalho apresentado em ARVO Annual Meeting Abstract, 2015.
- Miguel C Seabra. "Rab27a GTPase modulates L-type Ca2+ channel function via direct interaction with the Ca(V)1.3 subunit".
2015.
- Miguel C Seabra. "Enhancement of non-viral gene delivery to primary mouse retinal pigment epithelium cells using paramagnetic
nanoparticles". Trabalho apresentado em ARVO Annual Meeting, 2015.
- Seabra, Miguel C.; Futter, Clare; Evans, Martin J.; Wavre-Shapton, Silene; Feleciano, Diogo A.; Tolmachova, Tanya. "AMD-compatible
lysosomal changes in Rab38-deficient mouse model". Trabalho apresentado em ARVO Annual Meeting, 2014.
- Miguel C Seabra. "Translational bypass therapy using ataluren to treat nonsense-mediated choroideremia". Trabalho apresentado
em ARVO Annual Meeting, 2014.
- Futter, Clare; Seabra, Miguel C.; Tolmachova, Tanya; Meschede, Ingrid Porpino. "Mechanisms of photoreceptor degeneration in
choroideremia". Trabalho apresentado em ARVO Annual Meeting, 2014.
- Tolmachova, Tanya; Seabra, Miguel; Hughes, Alun; Douglass, Angela; Coxon, Fraser. "RAB27 KNOCKOUT MICE HAVE LOW BONE DENSITY
DUE TO DEFECTIVE OSTEOBLAST FUNCTION". 2012.
- Seabra, M. C.; Barral, D. C.; Pereira, F. J. C.; Iannone, L.; Tarafder, A. K.; Correia, M. S.. "Optimizing an endocytosis
assay for the characterization of melanin uptake and processing by keratinocytes". Trabalho apresentado em Meeting of the
Society for Pigment Cell Research, 2012.
- Miguel C Seabra. "Pathogenesis of diseases involving defects in Rab GTPase function and membrane traffic". Trabalho apresentado
em 36th FEBS Congress of the Biochemistry for Tomorrows Medicine, 2011.
- Seabra, M. C.. "Rab GTPases in membrane traffic and disease". Trabalho apresentado em 33rd Annual Meeting of the German-Society-for-Cell-Biology/German
Melanoma Research Network, 2010.
- Seabra, M. C.; Harbottle, R. P.; Tolmachova, T.; Tracey-White, D. C.; Wong, S. P.; Moosajee, M.; Ostad-Saffari, E.. "Persistent
Expression of Non-Viral S/MAR Vectors in the RPE for Choroideremia Gene Therapy". Trabalho apresentado em ARVO Annual Meeting,
2010.
- Gerke, V; Cutler, D.; Seabra, M.; Darchen, F.; Pulido, Rojo, I. "Myosin Va in regulated exocytosis of Weibel-Palade bodies".
Trabalho apresentado em 33rd Annual Meeting of the German-Society-for-Cell-Biology/German Melanoma Research Network,
2010.
- Westbroek, W.; De Wever, O.; Gahl, W.; Seabra, M.; Bracke, M.; Cocquyt, V; Van Belle, S.; et al. "The Secretory Small GTPase
Rab27B Regulates Invasive Tumor Growth and Metastasis through Extracellular Heat Shock Protein 90 alpha". Trabalho apresentado
em 32nd Annual San Antonio Breast Cancer Symposium, 2009.
- Seabra, Miguel C.; Wavre, Silene T.; Lopes, Vanda S.; Futter, Clare E.. "Melanosome biogenesis, transport and function in
retinal pigment epithelial cells". 2008.
- McKenna, C. E.; Rogers, M. J.; Seabra, M. C.; Ebetino, F. H.; Kashemirov, B. A.; Blazewska, K. M.; Marma, M. S.; et al. "Inhibition
of Rab geranylgeranyl transferase and Rab prenylation by phosphonocarboxylate drugs". 2008.
- Rogers, MJ; Seabra, MC; Mules, EH; Taylor, A; Coxon, FP. "Osteoclasts from gunmetal mice are defective in Rab prenylation
but not in bone resorption". Trabalho apresentado em nd Joint Meeting of the European-Calcified-Tissue-Society/International-Bone-and-Mineral-Society,
2005.
- Coxon, FP; Rogers, MJ; Seabra, MC; Mules, EH; Taylor, A. "Osteoclasts derived from gunmetal mice are functional despite having
defects in Rab prenylation". Trabalho apresentado em Annual Meeting of the Bone-and-Tooth-Society, 2005.
- Huxley, C; Seeliger, M; Tanimoto, N; Tonagel, F; Futter, C; Ramalho, JS; Abrink, M; et al. "Choroideremia mouse model generated
by conditional Rep1 knock-out". Trabalho apresentado em ARVO Annual Meeting, 2005.
- Seabra, MC. "Rab GTPAses and the control of membrane traffic in bone cells". Trabalho apresentado em 2nd Joint Meeting
of the European-Calcified-Tissue-Society/International-Bone-and-Mineral-Society, 2005.
- Seabra, MC; Pereira, PC; Futter, CE; Lopes, VS; Ramalho, JS. "Intracellular trafficking of melanosomes in the retinal pigmented
epithelium: mapping of interactions between Rab27a, Myrip and MyoVIIa". Trabalho apresentado em ARVO Annual Meeting,
2004.
- Rogers, MJ; Ebetino, FH; Seabra, M; Mules, E; Coxon, FP. "A phosphonocarboxylate analogue of risedronate (NE10790) inhibits
Rab prenylation in osteoclasts in vivo and disrupts the membrane localization of Rab proteins in osteoclasts in vitro". 2002.
- Hopkins, CR; Collinson, LM; Authi, KS; Hume, AN; Mules, EH; Ramalho, JS; Barral, DC; Seabra, MC. "Function of Rab27 proteins
and implications for disease". 2001.
- Seabra, MC; Strom, M; Gomes, AQ. "Importance of the prenylation motif on the membrane targeting of Rab GTPases". 2001.
- Rogers, MJ; Ebetino, FH; Seabra, MC; Nesbitt, SA; Larijani, B; Horton, MA; Marshall, D; et al. "A novel inhibitor of Rab prenylation
causes basolateral membrane changes in osteoclasts and reduces their resorptive activity". 2001.
- Rogers, MJ; Ebetino, FH; Seabra, MC; Dunford, J; Larijani, B; Coxon, FP. "Discovery of a novel inhibitor of RAB geranylgeranyl
transferase that inhibits bone resorption by selectively preventing prenylation of RAB proteins in osteoclasts". 2001.
- Shivdasani, RA; Swank, R; Seabra, M; Hartwig, J; Novak, E; Schwer, H; Italiano, J; Tiwari, S. "A role for the Rab sub-family
of Ras GTPases in formation and release of blood platelets". 2000.
- Kingsmore, S; Swank, R; Seabra, M; Wallace, M; Mishra, V; Novak, E; Mules, E; Zhang, Q; Detter, JC. "Positional cloning of
the, gunmetal mouse mutations". 1999.
- Seabra, MC; Huxley, C; Ramalho, JS. "The role of Rab27a in the pathogenesis of choroideremia: Generation of transgenic mice
expressing dominant-negative mutants of Rab27a". 1999.
- Burke, S; Desnoyers, L; Anant, JS; Seabra, MC. "Molecular pathogenesis of choroideremia: Kinetics of REP:RAB binding". 1997.
- MacDonald, IM; Seabra, MC; Ho, YK; Mah, DY. "Biochemical and mutational analysis of the REP-1 gene in a family with choroideremia".
1997.
- Zhang, H.; Seabra, M. C.; Deisenhofer, J.. "Preliminary X-ray structure analysis of Rab geranylgeranyl transferase". 1996.
10.1107/s0108767396094664
- Ye, J; Seabra, MC. "Nucleotide dependence of RAB geranylgeranylation: Detection of a soluble RAB GTPase activating protein
(RAB GAP) that stimulates RAB-GTP geranylgeranylation". 1996.
- SEABRA, MC. "THE PATHOGENESIS OF CHOROIDEREMIA - IDENTIFICATION OF A REP-1 SPECIFIC RAB". 1995.
- GOLDSTEIN, JL; BROWN, MS; ARMSTRONG, SA; CREMERS, FPM; SEABRA, MC. "DEFICIENCY OF RAB GERANYLGERANYLATION IN CHOROIDEREMIA
- ROLE OF RAB ESCORT PROTEINS". 1994.
- Miguel C Seabra. "CDNA CLONING AND EXPRESSION OF COMPONENT-A OF RAT RAB GERANYLGERANYL TRANSFERASE". 1993.
- Reiss, Y.; Seabra, M.C.; Brown, M.S.; Goldstein, J.L.. "p21ras farnesyltransferase: purification and properties of the enzyme.".
1992.
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