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Identificação

Identificação pessoal

Nome completo
Maria de Fátima Oliveira Ferreirinha

Nomes de citação

  • Ferreirinha, F.

Identificadores de autor

Ciência ID
5914-894C-CDD9
ORCID iD
0000-0002-0527-1323
Researcher Id
K-8752-2014
Scopus Author Id
6506893990

Moradas

  • ICBAS - Instituto de Ciências Biomédicas Abel Salazar. Laboratório Farmacologia e Neurobiologia, ICBAS - Rua Jorge Viterbo Ferreira, 228, 4050-313, Porto, Porto, Portugal (Profissional)

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Farmacologia e Farmácia
  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências
Formação
Grau Classificação
2006
Concluído
Ph.D. Thesis (Doutoramento)
Especialização em Biomedical Sciences
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Molecular genetics and pathogenetic mechanism of hereditary spastic paraplegias" (TESE/DISSERTAÇÃO)
Aproved by unanimity
Projetos

Projeto

Designação Financiadores
2020/07/09 - 2021/03/09 RESEARCH 4 COVID-19 - PURINOME-REJUVENATED AUTOLOGOUS STEM CELLS AGAINST COVID-19. WHO'S GONNA WIN THE AGEING BATTLE?
402
Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em revista
  1. Bessa-Andrês, Catarina; Pinto-Cardoso, Rui; Tarasova, Karyna; Pereira-Gonçalves, Ana Luísa; Gaio-Ferreira-Castro, Joana Maria; Carvalho, Liliana S.; Costa, Maria Adelina; et al. "Mechanical stimulation-induced purinome priming fosters osteogenic differentiation and osteointegration of mesenchymal stem cells from the bone marrow of post-menopausal women". Stem Cell Research & Therapy 15 1 (2024): https://doi.org/10.1186/s13287-024-03775-4.
    Acesso aberto • Publicado • 10.1186/s13287-024-03775-4
  2. Bessa-Gonçalves, Mafalda; Bragança, Bruno; Martins-Dias, Eduardo; Vinhas, Adriana; Certal, Mariana; Rodrigues, Tânia; Ferreirinha, Fátima; et al. "Blockage of the adenosine A2B receptor prevents cardiac fibroblasts overgrowth in rats with pulmonary arterial hypertension". Purinergic Signalling (2023): http://dx.doi.org/10.1007/s11302-023-09952-z.
    10.1007/s11302-023-09952-z
  3. Noronha-Matos, José Bernardo; Pinto-Cardoso, Rui; Bessa-Andrês, Catarina; Magalhães-Cardoso, Maria Teresa; Ferreirinha, Fátima; Costa, Maria Adelina; Marinhas, José; et al. "Silencing NTPDase3 activity rehabilitates the osteogenic commitment of post-menopausal stem cell bone progenitors". Stem Cell Research & Therapy 14 1 (2023): http://dx.doi.org/10.1186/s13287-023-03315-6.
    10.1186/s13287-023-03315-6
  4. Herman-de-Sousa, Carina; Costa, Maria Adelina; Silva, Rafaela Pedro; Ferreirinha, Fátima; Ribeiro, Severino; Correia-de-Sá, Paulo. "A2A receptor-induced overexpression of pannexin-1 channels indirectly mediates adenosine fibrogenic actions by favouring ATP release from human subcutaneous fibroblasts". Life Sciences 310 (2022): 121080. http://dx.doi.org/10.1016/j.lfs.2022.121080.
    10.1016/j.lfs.2022.121080
  5. Guerra Leal, Bárbara; Barros-Barbosa, Aurora; Ferreirinha, Fátima; Chaves, João; Rangel, Rui; Santos, Agostinho; Carvalho, Cláudia; et al. "Mesial Temporal Lobe Epilepsy (MTLE) Drug-Refractoriness Is Associated With P2X7 Receptors Overexpression in the Human Hippocampus and Temporal Neocortex and May Be Predicted by Low Circulating Levels of miR-22". Frontiers in Cellular Neuroscience 16 (2022): http://dx.doi.org/10.3389/fncel.2022.910662.
    10.3389/fncel.2022.910662
  6. Ferreirinha, F.. "Non-genomic Actions of Methylprednisolone Differentially Influence GABA and Glutamate Release From Isolated Nerve Terminals of the Rat Hippocampus.". Frontiers in molecular neuroscience (2020): https://europepmc.org/articles/PMC7419606.
    10.3389/fnmol.2020.00146
  7. Herman-de-Sousa, Carina; Pinheiro, Ana Rita; Paramos-de-Carvalho, Diogo; Costa, Maria Adelina; Ferreirinha, Fátima; Magalhães-Cardoso, Teresa; Ribeiro, Severino; et al. "Opposing Effects of Adenosine and Inosine in Human Subcutaneous Fibroblasts May Be Regulated by Third Party ADA Cell Providers". Cells 9 3 (2020): 651. http://dx.doi.org/10.3390/cells9030651.
    10.3390/cells9030651
  8. Silva, Isabel; Magalhães-Cardoso, M. Teresa; Ferreirinha, Fátima; Moreira, Sílvia; Costa, Ana Filipa; Silva, Diogo; Vieira, Cátia; Silva-Ramos, Miguel; Correia-de-Sá, Paulo. "ß 3 Adrenoceptor-induced cholinergic inhibition in human and rat urinary bladders involves the exchange protein directly activated by cyclic AMP 1 favoring adenosine release". British Journal of Pharmacology 177 7 (2020): 1589-1608. http://dx.doi.org/10.1111/bph.14921.
    10.1111/bph.14921
  9. Silva-Ramos, M.; Silva, I.; Faria, M.; Ferreirinha, F.; Correia-de-Sá, P.. "Activation of Prejunctional P2x2/3 Heterotrimers by ATP Enhances the Cholinergic Tone in Obstructed Human Urinary Bladders". Journal of Pharmacology and Experimental Therapeutics 372 1 (2019): 63-72. http://dx.doi.org/10.1124/jpet.119.261610.
    10.1124/jpet.119.261610
  10. Bragança, Bruno; Nogueira-Marques, Sílvia; Ferreirinha, Fátima; Fontes-Sousa, Ana Patrícia; Correia-de-Sá, Paulo. "The Ionotropic P2X4 Receptor has Unique Properties in the Heart by Mediating the Negative Chronotropic Effect of ATP While Increasing the Ventricular Inotropy". Frontiers in Pharmacology 10 (2019): http://dx.doi.org/10.3389/fphar.2019.01103.
    10.3389/fphar.2019.01103
  11. Figueira, Luis; Janeiro, Catarina; Ferreirinha, Fatima; Serrao, Paula; Perestrelo, Sara; Falcao-Reis, Fernando; Correia-de-Sa, Paulo; Moura, Daniel. "Regulation of corneal noradrenaline release and topography of sympathetic innervation: Functional implications for adrenergic mechanisms in the human cornea". Experimental Eye Research 174 (2018): 121-132. http://dx.doi.org/10.1016/j.exer.2018.05.023.
    10.1016/j.exer.2018.05.023
  12. Vieira, Cátia; Ferreirinha, Fátima; Magalhães-Cardoso, Maria T.; Silva, Isabel; Marques, Patrícia; Correia-de-Sá, Paulo. "Post-inflammatory Ileitis Induces Non-neuronal Purinergic Signaling Adjustments of Cholinergic Neurotransmission in the Myenteric Plexus". Frontiers in Pharmacology 8 (2017): http://dx.doi.org/10.3389/fphar.2017.00811.
    10.3389/fphar.2017.00811
  13. Silva, Isabel; Costa, Ana Filipa; Moreira, Sílvia; Ferreirinha, Fátima; Magalhães-Cardoso, Maria Teresa; Calejo, Isabel; Silva-Ramos, Miguel; Correia-de-Sá, Paulo. "Inhibition of cholinergic neurotransmission by ß3-adrenoceptors depends on adenosine release and A1-receptor activation in human and rat urinary bladders". American Journal of Physiology-Renal Physiology 313 2 (2017): F388-F403. http://dx.doi.org/10.1152/ajprenal.00392.2016.
    10.1152/ajprenal.00392.2016
  14. Certal, Mariana; Vinhas, Adriana; Barros-Barbosa, Aurora; Ferreirinha, Fátima; Costa, Maria Adelina; Correia-de-Sá, Paulo. "ADP-Induced Ca2+ Signaling and Proliferation of Rat Ventricular Myofibroblasts Depend on Phospholipase C-Linked TRP Channels Activation Within Lipid Rafts". Journal of Cellular Physiology 232 6 (2016): 1511-1526. http://dx.doi.org/10.1002/jcp.25656.
    10.1002/jcp.25656
  15. Barros-Barbosa, Aurora R.; Ferreirinha, Fátima; Oliveira, Ângela; Mendes, Marina; Lobo, M. Graça; Santos, Agostinho; Rangel, Rui; et al. "Adenosine A2A receptor and ecto-5'-nucleotidase/CD73 are upregulated in hippocampal astrocytes of human patients with mesial temporal lobe epilepsy (MTLE)". Purinergic Signalling 12 4 (2016): 719-734. http://dx.doi.org/10.1007/s11302-016-9535-2.
    10.1007/s11302-016-9535-2
  16. Bragança, Bruno; Oliveira-Monteiro, Nádia; Ferreirinha, Fátima; Lima, Pedro A.; Faria, Miguel; Fontes-Sousa, Ana P.; Correia-de-Sá, Paulo. "Ion Fluxes through KCa2 (SK) and Cav1 (L-type) Channels Contribute to Chronoselectivity of Adenosine A1 Receptor-Mediated Actions in Spontaneously Beating Rat Atria". Frontiers in Pharmacology 7 (2016): http://dx.doi.org/10.3389/fphar.2016.00045.
    10.3389/fphar.2016.00045
  17. Barros-Barbosa, Aurora R.; Fonseca, Ana L.; Guerra-Gomes, Sónia; Ferreirinha, Fátima; Santos, Agostinho; Rangel, Rui; Lobo, M. Graça; Correia-de-Sá, Paulo; Cordeiro, J. Miguel. "Up-regulation of P2X7 receptor-mediated inhibition of GABA uptake by nerve terminals of the human epileptic neocortex". Epilepsia 57 1 (2015): 99-110. http://dx.doi.org/10.1111/epi.13263.
    10.1111/epi.13263
  18. Silva-Ramos, M.; Silva, I.; Faria, M.; Magalhães-Cardoso, M. T.; Correia, J.; Ferreirinha, F.; Correia-de-Sá, P.. "Impairment of ATP hydrolysis decreases adenosine A1 receptor tonus favoring cholinergic nerve hyperactivity in the obstructed human urinary bladder". Purinergic Signalling 11 4 (2015): 595-606. http://dx.doi.org/10.1007/s11302-015-9478-z.
    Publicado • 10.1007/s11302-015-9478-z
  19. Silva I; Ferreirinha F; Magalhães-Cardoso MT; Silva-Ramos M; Correia-de-Sá P. "Activation of P2Y6 Receptors Facilitates Nonneuronal Adenosine Triphosphate and Acetylcholine Release from Urothelium with the Lamina Propria of Men with Bladder Outlet Obstruction.". (2015): http://europepmc.org/abstract/med/26004864.
    10.1016/j.juro.2015.05.080
  20. Barros-Barbosa AR; Lobo MG; Ferreirinha F; Correia-de-Sá P; Cordeiro JM. "P2X7 receptor activation downmodulates Na(+)-dependent high-affinity GABA and glutamate transport into rat brain cortex synaptosomes.". (2015): http://europepmc.org/abstract/med/26299340.
    10.1016/j.neuroscience.2015.08.026
  21. Certal M; Vinhas A; Pinheiro AR; Ferreirinha F; Barros-Barbosa AR; Silva I; Costa MA; Correia-de-Sá P. "Calcium signaling and the novel anti-proliferative effect of the UTP-sensitive P2Y11 receptor in rat cardiac myofibroblasts.". (2015): http://europepmc.org/abstract/med/26324417.
    10.1016/j.ceca.2015.08.004
  22. Oliveira L; Correia A; Cristina Costa A; Guerra-Gomes S; Ferreirinha F; Magalhães-Cardoso MT; Vilanova M; Correia-de-Sá P. "Deficits in endogenous adenosine formation by ecto-5'-nucleotidase/CD73 impair neuromuscular transmission and immune competence in experimental autoimmune myasthenia gravis.". (2015): http://europepmc.org/abstract/med/25691808.
    10.1155/2015/460610
  23. Noronha-Matos JB; Coimbra J; Sá-E-Sousa A; Rocha R; Marinhas J; Freitas R; Guerra-Gomes S; et al. "P2X7-induced zeiosis promotes osteogenic differentiation and mineralization of postmenopausal bone marrow-derived mesenchymal stem cells.". (2014): http://europepmc.org/abstract/med/25169056.
    10.1096/fj.14-257923
  24. Moreira-Rodrigues M; Graca AL; Ferreira M; Afonso J; Serrao P; Morato M; Ferreirinha F; et al. "Attenuated aortic vasodilation and sympathetic prejunctional facilitation in epinephrine-deficient mice: selective impairment of ß2-adrenoceptor responses.". (2014): http://europepmc.org/abstract/med/25161169.
    10.1124/jpet.114.217281
  25. Carneiro I; Timóteo MA; Silva I; Vieira C; Baldaia C; Ferreirinha F; Silva-Ramos M; Correia-de-Sá P. "Activation of P2Y6 receptors increases the voiding frequency in anaesthetized rats by releasing ATP from the bladder urothelium.". (2014):
    10.1111/bph.12711
  26. Vieira C; Magalhães-Cardoso MT; Ferreirinha F; Silva I; Dias AS; Pelletier J; Sévigny J; Correia-de-Sá P. "Feed-forward inhibition of CD73 and upregulation of adenosine deaminase contribute to the loss of adenosine neuromodulation in postinflammatory ileitis.". (2014): http://europepmc.org/abstract/med/25210228.
    10.1155/2014/254640
  27. Sousa JB; Vieira-Rocha MS; Sá C; Ferreirinha F; Correia-de-Sá P; Fresco P; Diniz C. "Lack of endogenous adenosine tonus on sympathetic neurotransmission in spontaneously hypertensive rat mesenteric artery.". (2014):
    10.1371/journal.pone.0105540
  28. Correia-de-Sá, P.; Noronha-Matos, J.B.; Timóteo, M.A.; Ferreirinha, F.; Marques, P.; Soares, A.M.; Carvalho, C.; Cavalcante, W.L.G.; Gallacci, M.. "Bothropstoxin-I reduces evoked acetylcholine release from rat motor nerve terminals: Radiochemical and real-time video-microscopy studies". Toxicon 61 1 (2013): 16-25. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870206270&partnerID=MN8TOARS.
    10.1016/j.toxicon.2012.10.014
  29. Pinheiro, A.R.; Paramos-De-carvalho, D.; Certal, M.; Costa, M.A.; Costa, C.; Magalhães-Cardoso, M.T.; Ferreirinha, F.; Sévigny, J.; Correia-De-Sá, P.. "Histamine induces ATP release from human subcutaneous fibroblasts, via pannexin-1 hemichannels, leading to Ca2+ mobilization and cell proliferation". Journal of Biological Chemistry 288 38 (2013): 27571-27583. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884575578&partnerID=MN8TOARS.
    10.1074/jbc.M113.460865
  30. Pinheiro, A.R.; Paramos-De-Carvalho, D.; Certal, M.; Costa, C.; Magalhães-Cardoso, M.T.; Ferreirinha, F.; Costa, M.A.; Correia-De-Sá, P.. "Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation". Cell Communication and Signaling 11 1 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84884192964&partnerID=MN8TOARS.
    10.1186/1478-811X-11-70
  31. Timóteo, M.A.; Carneiro, I.; Silva, I.; Noronha-Matos, J.B.; Ferreirinha, F.; Silva-Ramos, M.; Correia-de-Sá, P.. "ATP released via pannexin-1 hemichannels mediates bladder overactivity triggered by urothelial P2Y6 receptors". Biochemical Pharmacology (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84889011623&partnerID=MN8TOARS.
    10.1016/j.bcp.2013.11.007
  32. Noronha-Matos, J.B.; Costa, M.A.; Magalhães-Cardoso, M.T.; Ferreirinha, F.; Pelletier, J.; Freitas, R.; Neves, J.M.; Sévigny, J.; Correia-de-Sá, P.. "Role of ecto-NTPDases on UDP-sensitive P2Y 6 receptor activation during osteogenic differentiation of primary bone marrow stromal cells from postmenopausal women". Journal of Cellular Physiology 227 6 (2012): 2694-2709. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857467325&partnerID=MN8TOARS.
    10.1002/jcp.23014
  33. Costa, M.A.; Barbosa, A.; Neto, E.; Sá-E-Sousa, A.; Freitas, R.; Neves, J.M.; Magalhães-Cardoso, T.; Ferreirinha, F.; Correia-De-Sá, P.. "On the role of subtype selective adenosine receptor agonists during proliferation and osteogenic differentiation of human primary bone marrow stromal cells". Journal of Cellular Physiology 226 5 (2011): 1353-1366. http://www.scopus.com/inward/record.url?eid=2-s2.0-79951807194&partnerID=MN8TOARS.
    10.1002/jcp.22458
  34. Vieira, C.; Ferreirinha, F.; Silva, I.; Duarte-Araújo, M.; Correia-De-Sá, P.. "Localization and function of adenosine receptor subtypes at the longitudinal muscle-Myenteric plexus of the rat ileum". Neurochemistry International 59 7 (2011): 1043-1055. http://www.scopus.com/inward/record.url?eid=2-s2.0-80055012521&partnerID=MN8TOARS.
    10.1016/j.neuint.2011.08.016
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  36. Ferreirinha, F.; Quattrini, A.; Pirozzi, M.; Valsecchi, V.; Dina, G.; Broccoli, V.; Auricchio, A.; et al. "Axonal degeneration in paraplegin-deficient mice is associated with abnormal mitochondria and impairment of axonal transport". Journal of Clinical Investigation 113 2 (2004): 231-242. http://www.scopus.com/inward/record.url?eid=2-s2.0-1342310772&partnerID=MN8TOARS.
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  40. Ferreirinha, F.; Duarte, M.; Melo, A.M.P.; Videira, A.. "Effects of disrupting the 21 kDa subunit of complex I from Neurospora crassa". Biochemical Journal 342 3 (1999): 551-554. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033568709&partnerID=MN8TOARS.
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