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Hannah S Heil graduated in 2015 in Nanotechnology (MSc. Nanostrukturtechnik) from the Julius-Maximilian-University of Würzburg and completed a doctoral degree (Dr. rer. nat.) with the Graduate School of Life Science at the same University in 2020. Since obtaining her Master’s degree Hannah S Heil published 6 articles in international peer reviewed journals, the 3 first author publications achieve an accumulated impact factor of 49.5. During her doctoral studies Hannah S Heil presented her work at international conferences in both poster (Focus on Microscopy 2019 – London, Biophysical Society 62nd Annual Meeting - San Francisco, SMLM Symposium 2018 - Berlin) and oral presentations (Focus on Microscopy 2017 – Bordeaux, 53rd Winter Seminar 2018 -Klosters). Her work was highlighted as a Flash talk at the Focus on Microscopy 2019 and as a Rapid-Fire Talk at the Biophysical Society 62nd Annual Meeting. In her position as a doctoral student and continuing later as a postdoctoral researcher at the Rudolf Virchow Center for Integrative and Translational Bioimaging of the University of Würzburg Hannah S Heil has trained and supervised students pursuing Msc. (2) and MD degrees (3). Furthermore, beyond the project of her doctoral studies Hannah S Heil successfully worked in collaboration with fundamental, pre-clinical and even clinical scientists at the Biocenter, the Rudolf Virchow Center and university hospital in Würzburg. Hannah S Heil was involved in two Collaborative Research Centers (DFG-funded CRC/TR166: ReceptorLight, Würzburg & Jena, and CRC/TR240: Platelets, Würzburg & Tübingen). Hannah S Heil contributes to the life science community as a member of the German Physics Society (DPG) and the Biophysical Society. In 2019 Hannah S Heil was selected as participant of the Janelia Junior Scientist Workshop on Biological Optical Microscopy at Janelia Farm, USA, to explore and discuss emerging techniques and challenges within an interdisciplinary environment. Hannah S Heil actively advocates her science via twitter (@Hannah_SuperRes, 437 followers, up to 15 000 impressions) and ensures accessibility of her work by publishing preprints (bioRxiv) and sharing data and code on public repositories (Zenodo, OSF).
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Identificação

Identificação pessoal

Nome completo
Hannah Sophie Heil

Nomes de citação

  • Heil, Hannah
  • Heil, Hannah S

Identificadores de autor

Ciência ID
8713-C84C-78A8
ORCID iD
0000-0003-4279-7022

Endereços de correio eletrónico

  • hsheil@igc.gulbenkian.pt (Profissional)
  • hannah.heil@uni-wuerzburg.de (Profissional)

Moradas

  • Rua da Quinta Grande, 6, 2780-156, Oeiras, Lisboa, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências da Engenharia e Tecnologias - Nanotecnologia - Nanomateriais
  • Ciências Naturais - Ciências Biológicas - Biofísica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Alemão (Idioma materno)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Espanhol; Castelhano Utilizador elementar (A1) Utilizador elementar (A2) Utilizador elementar (A1) Utilizador elementar (A1)
Formação
Grau Classificação
2015/09/01 - 2020/05/13
Concluído
 Graduate School of Life Science (Doktor (PhD))
Especialização em Biomedicine
Julius-Maximilians-Universität Würzburg, Alemanha
"Sharpening super-resolution by single molecule localization microscopy in front of a tuned mirror" (TESE/DISSERTAÇÃO)
 Magna cum laude (Aprovado com Louvor e Distinção)
2013/04/01 - 2015/03/26
Concluído
 Nanostructure Technology (Master)
Especialização em Nanostructure Technology
Julius-Maximilians-Universitat Würzburg Fakultät für Physik und Astronomie, Alemanha
"Investigation of nano-optical fields with self-propelled quantum dot probes" (TESE/DISSERTAÇÃO)
 very good (19,4)
2009/10 - 2013/02/22
Concluído
 Nanostructur Technology (Bachelor)
Julius-Maximilians-Universitat Würzburg Fakultät für Physik und Astronomie, Alemanha
"Optimierung der Nanogelherstellung an Thiomeren mittels inverser Miniemulsion" (TESE/DISSERTAÇÃO)
 good (17,6)
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2020/12/01 - Atual Pós-doutorado (Investigação) Instituto Gulbenkian de Ciência, Portugal
Instituto Gulbenkian de Ciência, Portugal
2015/09/01 - 2020/11/30 Investigador (Investigação) Julius-Maximilians-Universität Würzburg, Alemanha
Rudolf Virchow Center for Integrative and Translational Bioimaging, Alemanha
2014/04/01 - 2015/07/31 Estagiário de Investigação (Investigação) Technische Universität Dresden, Alemanha
B CUBE – Center for Molecular Bioengineering, Technische Universität Dresden, Alemanha
Projetos

Bolsa

Designação Financiadores
2020/01/01 - 2020/09/01 CRC/Transregio 240 Platelets – Molecular, cellular and systemic functions in health and disease
374031971
Investigador Pós-doutorado
Deutsche Forschungsgemeinschaft
Em curso

Projeto

Designação Financiadores
2015/09/01 - 2020/05/13 Sharpening super-resolution by single molecule localization microscopy in front of a tuned mirror
258780946
Bolseiro de Doutoramento
Julius-Maximilians-Universität Würzburg, Alemanha
 Deutsche Forschungsgemeinschaft
Concluído
2014/04/01 - 2015/07/31 Investigation of nano-optical fields with selfpropelled quantum dot probes
NON-FUNDED
Bolseiro de Mestrado
Technische Universität Dresden, Alemanha

Julius-Maximilians-Universitat Würzburg Fakultät für Physik und Astronomie, Alemanha
Concluído
Produções

Publicações

Artigo em revista
  1. Romain F. Laine; Hannah S. Heil; Simao Coelho; Jonathon Nixon-Abell; Angélique Jimenez; Theresa Wiesner; Damián Martínez; et al. "High-fidelity 3D live-cell nanoscopy through data-driven enhanced super-resolution radial fluctuation". Nature Methods (2023): https://doi.org/10.1038/s41592-023-02057-w.
    10.1038/s41592-023-02057-w
  2. Luise Appeltshauser; Janis Linke; Hannah S. Heil; Christine Karus; Joachim Schenk; Katherina Hemmen; Claudia Sommer; Kathrin Doppler; Katrin G. Heinze. "Super-resolution imaging pinpoints the periodic ultrastructure at the human node of Ranvier and its disruption in patients with polyneuropathy". Neurobiology of Disease (2023): http://dx.doi.org/10.1016/j.nbd.2023.106139.
    10.1016/j.nbd.2023.106139
  3. Afonso Mendes; Hannah S. Heil; Simao Coelho; Christophe Leterrier; Ricardo Henriques. "Mapping molecular complexes with super-resolution microscopy and single-particle analysis". Open Biology (2022): https://doi.org/10.1098/rsob.220079.
    10.1098/rsob.220079
  4. Hannah S. Heil; Max Aigner; Sophia Maier; Prateek Gupta; Luise M.C. Evers; Vanessa Göb; Charly Kusch; et al. "Mapping densely packed aIIbß3 receptors in murine blood platelets with expansion microscopy". Platelets (2022): https://doi.org/10.1080/09537104.2021.2023735.
    10.1080/09537104.2021.2023735
  5. Artemis G. Korovesi; Leonor Morgado; Marco Fumasoni; Ricardo Henriques; Hannah S. Heil; Mario Del Rosario. "Expansion Microscopy on Saccharomyces cerevisiae". (2022): https://www.micropublication.org/journals/biology/micropub-biology-000566.
    10.17912/MICROPUB.BIOLOGY.000566
  6. Mario Del Rosario; Hannah S. Heil; Afonso Mendes; Vittorio Saggiomo; Ricardo Henriques. "The Field Guide to 3D Printing in Optical Microscopy for Life Sciences". Advanced Biology (2021): https://doi.org/10.1002/adbi.202100994.
    10.1002/adbi.202100994
  7. Julia Volz; Charly Kusch; Sarah Beck; Michael Popp; Timo Vögtle; Mara Meub; Inga Scheller; et al. "BIN2 orchestrates platelet calcium signaling in thrombosis and thrombo-inflammation". Journal of Clinical Investigation 130 11 (2020): 6064-6079. https://doi.org/10.1172/JCI136457.
    Publicado • 10.1172/JCI136457
  8. Bangalore, Disha M.; Heil, Hannah S; Mehringer, Christian F; Hirsch, Lisa; Hemmen, Katherina; Heinze, Katrin G.; Tessmer, Ingrid. "Automated AFM analysis of DNA bending reveals initial lesion sensing strategies of DNA glycosylases.". Scientific reports 10 1 (2020): 15484. http://europepmc.org/abstract/med/32968112.
    Acesso aberto • Publicado • 10.1038/s41598-020-72102-7
  9. Hannah S. Heil; Benjamin Schreiber; Ralph Götz; Monika Emmerling; Marie-Christine Dabauvalle; Georg Krohne; Sven Höfling; et al. "Sharpening emitter localization in front of a tuned mirror". Light: Science & Applications 7 1 (2018): https://doi.org/10.1038/s41377-018-0104-z.
    Publicado • 10.1038/s41377-018-0104-z
  10. Heiko Groß; Hannah S. Heil; Jens Ehrig; Friedrich W. Schwarz; Bert Hecht; Stefan Diez. "Parallel mapping of optical near-field interactions by molecular motor-driven quantum dots". Nature Nanotechnology 13 8 (2018): 691-695. https://doi.org/10.1038/s41565-018-0123-1.
    Publicado • 10.1038/s41565-018-0123-1
  11. Schreiber, Benjamin; Heil, Hannah S.; Kamp, Martin; Heinze, Katrin G.. "Live-cell fluorescence imaging with extreme background suppression by plasmonic nanocoatings.". Optics express 26 16 (2018): 21301. http://europepmc.org/abstract/med/30119432.
    Acesso aberto • Publicado • 10.1364/oe.26.021301
  12. Benjamin Schreiber; Michael Kauk; Hannah S. Heil; Monika Emmerling; Ingrid Tessmer; Martin Kamp; Sven Höfling; et al. "Enhanced Fluorescence Resonance Energy Transfer in G-Protein-Coupled Receptor Probes on Nanocoated Microscopy Coverslips". ACS Photonics 5 6 (2018): 2225-2233. https://doi.org/10.1021%2Facsphotonics.8b00072.
    Publicado • 10.1021/acsphotonics.8b00072
Poster em conferência
  1. Heil, Hannah S. "Boosting resolution in fluorescence imaging by mirror enhanced localization microscopy". Trabalho apresentado em Focus on Microscopy 2019, London, UK, 2019.
  2. Max Aigner; Heil, Hannah S; Klaus, Vanessa; Sauer, Markus; Nieswandt, Bernhard; Stegner, David; Heinze, Katrin G.. "Expansion Microscopy on blood platelets". Trabalho apresentado em Focus on Microscopy 2019, London, UK, 2019.
  3. Heil, Hannah S. "Boosting resolution in fluorescence imaging and spectroscopy by mirror enhanced localization microscopy". Trabalho apresentado em 13th EUREKA! Symposium 2018, Würzburg, Germany, 2018.
  4. Heil, Hannah S. "Boosting resolution in fluorescence imaging and spectroscopy by metal-enhanced localization microscopy". Trabalho apresentado em Single Molecule Localization Microscopy Symposium 2018, Berlin, Germany, 2018.
  5. Heil, Hannah S. "Beyond the beaten track: Pushing the limits of fluorescence microscopy". Trabalho apresentado em DPG Spring Meeting 2017, Dresden, Germany, 2017.
  6. Heil, Hannah S. "Beyond the beaten track: Pushing the limits of fluorescence microscopy". Trabalho apresentado em 52nd Winter Seminar: Biophysical Chemistry, Molecular Biology & Cybernetics of Cell Function, Klosters, Switzerland, 2017.
Resumo em conferência
  1. Heil, Hannah S; Schreiber, Benjamin; Dabauvalle, Marie-Christine; Georg Krohne; Sven Höfling; Kamp, Martin; Sauer, Markus; Heinze, Katrin G.. "Boosting the Localization Precision in Super-Resolution Microscopy: booSTORM". Trabalho apresentado em Biophysical Society 62nd Annual Meeting, San Francisco, 2018.
    Publicado • https://doi.org/10.1016/j.bpj.2017.11.2899

Outros

Outra produção
  1. Boosting the localization precision of dSTORM by biocompatible metal-dielectric coated glass coverslips. Preprint on bioRxiv. 2017. Hannah S. Heil; Benjamin Schreiber; Monika Emmerling; Sven Hoefling; Martin Kamp; Markus Sauer; Katrin G. Heinze. https://doi.org/10.1101/136739.
    10.1101/136739
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2018/01 BOOSTorm: Boosting the localization precision in super-resolution microscopy 53nd Winter Seminar: Biophysical Chemistry, Molecular Biology & Cybernetics of Cell Function
(Klosters, Suiça)
2017/04/08 Boosting the localization precision of dSTORM Focus on Microscopy 2017
(Bordeaux, França)
2016/07/20 Beyond the beaten track: Pushing the limits of fluorescence microscopy Rudolf Virchow Center Summer Symposium 2016
(Würzburg)

Tutoria

Tópico Nome do aluno
2019/10 - 2020/06 Co-Supervision of MD student: Mapping receptor distributions on blood platelets with 10xExpansion Microscopy Sophia Maier
2019/09 - 2020/05 Co-Supervision of MD student: Ultrastructural investigation of protein architecture of nodes of Ranvier by dSTORM microscopy Christine Karus
2018/10 - 2019/05 Co-Supervision of MD student: Mapping receptor distributions on blood platelets with Expansion Microscopy Max Aigner
2017/11 - 2018/09 Co-Supervision of Master Student: Expansion Microscopy on Platelets Shazeb Ahmad
2017/06/01 - 2017/08/31 Co-Supervision of Bachelor Student: Characterization of metal-dielectric coated coverslips for enhanced fluorescence in biomedicine Thomas Müller
2017/06/01 - 2017/08/31 Co-Supervision of Bachelor Student: Calibration and Characterisation of an Anisotropy Setup for the Analysis of the Rotational Diffusion of Biologically Relevant Molecules Jan-Hagen Krohn
Distinções

Prémio

2021 EMBO Postdoctoral Fellowship
European Molecular Biology Organization (EMBO), Alemanha
2021 FCT CEEC Postdoctoral Fellowship 2021 (2021.01480.CEECIND)
Fundação para a Ciência e a Tecnologia, Portugal
2018 Best Poster Prize of the Rudolf Virchow Center Retreat, Bad Brückenau
2017 Best Poster Prize of the 52nd Winter Seminar
2017 1 st Prize Presentation Award of the Rudolf Virchow Center Retreat, Bad Brückenau

Outra distinção

2019 Flash Talk selection at the Focus on Microscopy 2019, London
2019 Janelia's Junior Scientist Workshop on Biological Optical Microscopy, Janelia Farm
Howard Hughes Medical Institute, Estados Unidos
2019 Travel grant
Graduate School of Life Sciences, University of Würzburg, Alemanha
2018 Rapid-Fire Talk selection at the Biophysical Society 62 nd Annual Meeting
Biophysical Society, Estados Unidos
2018 Travel grant
Graduate School of Life Sciences, University of Würzburg, Alemanha
2017 Travel grant
Graduate School of Life Sciences, University of Würzburg, Alemanha