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Rita C Acúrcio concluded her PhD in 2019 and is currently a Junior Researcher at the Research Institute for Medicines (iMedULisboa), integrated in the Faculty of Pharmacy - University of Lisboa. In 2022, Rita had an FCT-funded project as principal investigator (SM-UnLOCK, 50K¿). She is also responsible for a LaCaixa-funded project (CoVax, CF01-00014, 300K¿) on the COVID nanomedicine field, at BioNanoSciences - Drug Delivery & Immunoengineering Group. Rita developed her PhD studies in the discovery and development of new small-molecule immune system modulators for cancer treatment. Previously, she developed other projects during her Master's Thesis in Organic Chemistry at the University of Aveiro, which resulted in a total of 5 publications in international peer-reviewed journals (two as 1st author). Rita started her PhD in 2016 at Dr. Guedes and Dr. Florindo labs at iMedULisboa (Lisboa, Portugal), where her expertise allowed the development of unique immunomodulatory small molecules to reprogram tumor microenvironment. This technology inspired the FCT-funded project (SM-UnLOCK, 50K¿), 3 oral and 10 poster presentations, 3 publications, all as 1st author, 1 Provisional Patent Application (No. 63/150,643), and 1MSc project co-supervised by Rita. In 2020, she started a Post-Doctoral position in a LaCaixa-funded international consortium (NanoPanther, LCF/PR/HR19/52160021, 1M¿) on the pancreatic cancer nanomedicine field, involving iMedULisboa (Lisboa, Portugal), Prince Felipe Research Center (CIPF) (Valencia, Spain) and Tel Aviv University (Tel Aviv, Israel). As part of NanoPanther, she joined the Lab of Prof. Ronit Satchi-Fainaro, one of the most renowned groups in Cancer Research and Nanomedicine, at Tel Aviv University (Israel). Overall, Rita interacted with more than 50 authors (+6 nationalities), publishing in total of 16 articles and 3 conference proceedings. The publication list includes top specialty journals, such as Nat. Nanotech., J Med Chem or Adv Drug Deliv Rev. She was also awarded the cover image of the Nat. Nanotech. in August 2020. Rita presented her work at several national/international meetings. She was supported with 4 travel grants from renowned scientific societies to participate in highly recognized international meetings, including European Association for Cancer Research (EACR) and European Federation for Medicinal Chemistry (EFMC). Also, she was awarded a travel grant by European Commission-sponsored COST Mission (CA15135) to enroll in a training school at Fraunhofer-IME, in Hamburg. She is also actively mentoring and/or supervising PhD, MSc, and Undergraduate students.
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Identificação

Identificação pessoal

Nome completo
Ana Rita de Carvalho Acúrcio

Nomes de citação

  • Acúrcio, Rita C

Identificadores de autor

Ciência ID
8F1C-FAF0-2051
ORCID iD
0000-0003-3412-1903
Scopus Author Id
56154070500

Endereços de correio eletrónico

  • ritaacurcio@ff.ulisboa.pt (Profissional)

Domínios de atuação

  • Ciências Médicas e da Saúde - Biotecnologia Médica
  • Ciências Médicas e da Saúde - Medicina Clínica - Oncologia
  • Ciências da Engenharia e Tecnologias - Nanotecnologia
  • Ciências Médicas e da Saúde - Medicina Básica - Química Médica
  • Ciências Exatas - Química - Química Orgânica
Formação
Grau Classificação
2016/01/01 - 2019/12/16
Concluído
 Pharmacy (Doctor of Philosophy)
Especialização em Pharmaceutical and Therapeutic Chemistry
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Discovery and Development of Novel Small-Molecule Immune System Modulators" (TESE/DISSERTAÇÃO)
 Summa cum laude
2018/10/01 - 2018/10/04
Concluído
 IGC Course on Laboratory Animal Sciences in Mouse and Zebrafish (Outros)
Instituto Gulbenkian de Ciência, Portugal
2012/10 - 2014/07
Concluído
 Chemistry (Master)
Especialização em Organic Chemistry and Natural Products
Universidade de Aveiro, Portugal
"Synthesis of new C-glycosyl derivatives " (TESE/DISSERTAÇÃO)
 17
2009/09 - 2011/10
Concluído
 Chemistry (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
"New processes to activate the C-H bond and the synthesis of new natural products." (TESE/DISSERTAÇÃO)
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2023/04/03 - Atual Investigador (Investigação) Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2020/01/08 - 2022/04/30 Pós-doutorado (Investigação) Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
(...)
2020/01/09 - 2020/07/08 Investigador (Investigação) Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015/01/02 - 2015/12/31 Investigador (Investigação) Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2022 - 2022/12 Analytical Scientist - Project Support Hovione, Portugal
Hovione, Portugal
2016/01/01 - 2019/12/31 PhD student at Dr Rita Guedes and Dr Helena Florindo Labs (iMedULisboa, Lisboa), supported with a FCT scholarship PD/BD/128238/2016 Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
2012/02/01 - 2012/07/31 Visiting Undergradute student at Professor Dr. Jordi García Gómez Lab (Barcelona, Spain) Universitat de Barcelona, Espanha
Universitat de Barcelona Facultat de Química, Espanha
Projetos

Bolsa

Designação Financiadores
2020/01/08 - 2020/06/30 Modulation of melanoma-stroma interactions using a rationally-designed nanomedicine combining BRAFi-, MEKi- and immune-therapies
ENMed/0051/2016
Bolseiro de Investigação
Universidade de Lisboa Faculdade de Farmácia, Portugal

Tel Aviv University, Israel

Weizmann Institute of Science, Israel
Fundação para a Ciência e a Tecnologia
Em curso
2016/01/01 - 2019/12/31 Discovery and Development of New Small-Molecule Immune System Modulators
PD/BI/114135/2015
PD/BD/128238/2016
Bolseiro de Doutoramento
Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2015/01/02 - 2015/12/31 Reactivation of latent HIV-1 by extracellular factors secreted by opportunistic infectious bacteria
PEst-OE/SAU/UI0775/2013
Bolseiro de Investigação
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído

Projeto

Designação Financiadores
2023/04/03 - Atual Multifunctional nano-immunotherapy for melanoma brain metastases treatment
PTDC/BTM-SAL/4350/2021
Investigador
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Tel Aviv University Sackler Faculty of Medicine, Israel
Fundação para a Ciência e a Tecnologia
Em curso
2023/01 - Atual Multifunctional nano-immunotherapy against breast brain metastases
LCF/PR/HR22/52420016
Investigador
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Tel Aviv University Sackler Faculty of Medicine, Israel
CaixaForum Barcelona
Em curso
2022/01/01 - Atual New opportunities for small molecules in immuno-oncology
EXPL/MED-QUI/1316/2021
Investigador responsável
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2020/12 - Atual Development of a translational COVID-19 Vaccine
CF01-00014
Investigador
Universidade de Lisboa Faculdade de Farmácia, Portugal

Tel Aviv University, Israel
CaixaForum Barcelona
Em curso
2020/08/10 - 2022/04/30 Sensitizing pancreatic cancer to immunotherapy with multimodal precision nanomedicines
HR18-00589
Bolseiro de Pós-Doutoramento
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Tel Aviv University Sackler Faculty of Medicine, Israel

Centro de Investigacion Principe Felipe, Espanha
CaixaForum Barcelona
Em curso

Outro

Designação Financiadores
2023/03 - Atual ISIDORe
ISID_c7f4
Investigador responsável
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Tel Aviv University Sackler Faculty of Medicine, Israel
European Union
Em curso
Produções

Publicações

Artigo em conferência
  1. Carreira, Bárbara; Acúrcio, Rita C; Pozzi, Sabina; Ron Kleiner; Moura, Liane I F; Ana I. Matos; Daniella Vaskovich-Koubi; et al. Autor correspondente: Ronit Satchi. "Abstract 835: Translational nanotechnology-based cancer vaccine to re-educate host immune response against metastatic cancers". Trabalho apresentado em AACR Annual Meeting 2023, Orlando, 2023.
    Publicado • 10.1158/1538-7445.AM2023-835
Artigo em revista
  1. Matos, A.I.; Peres, C.; Carreira, B.; Moura, L.I.F.; Acúrcio, R.C.; Vogel, T.; Wegener, E.; et al. "Polyoxazoline-Based Nanovaccine Synergizes with Tumor-Associated Macrophage Targeting and Anti-PD-1 Immunotherapy against Solid Tumors". Advanced Science 10 25 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85164453502&partnerID=MN8TOARS.
    10.1002/advs.202300299
  2. Pais, Teresa F.; Ali, Hajrabibi; Moreira da Silva, Joana; Duarte, Nádia; Neres, Rita; Chhatbar, Chintan; Acúrcio, Rita C.; et al. "Brain endothelial STING1 activation by Plasmodium -sequestered heme promotes cerebral malaria via type I IFN response". Proceedings of the National Academy of Sciences 119 36 (2022): http://dx.doi.org/10.1073/pnas.2206327119.
    Publicado • 10.1073/pnas.2206327119
  3. Acúrcio, Rita C.; Pozzi, Sabina; Carreira, Barbara; Pojo, Marta; Gómez-Cebrián, Nuria; Casimiro, Sandra; Fernandes, Adelaide; et al. "Therapeutic targeting of PD-1/PD-L1 blockade by novel small-molecule inhibitors recruits cytotoxic T cells into solid tumor microenvironment". Journal for ImmunoTherapy of Cancer 10 7 (2022): e004695. http://dx.doi.org/10.1136/jitc-2022-004695.
    Publicado • 10.1136/jitc-2022-004695
  4. Snežana Ðordevic; María Medel Gonzalez; CONEJOS-SANCHEZ, INMACULADA; Carreira, Bárbara; Sabina Pozzi; Rita Acúrcio; Satchi-Fainaro, Ronit; Helena F Florindo; María Jesus Vicent. "Current hurdles to the translation of nanomedicines from bench to the clinic". Drug Delivery and Translational Research (2021): http://dx.doi.org/10.1007/s13346-021-01024-2.
    10.1007/s13346-021-01024-2
  5. Carina Peres; Ana I. Matos; Liane I.F. Moura; Rita C. Acúrcio; Barbara Carreira; Sabina Pozzi; Daniella Vaskovich-Koubi; et al. "Preclinical models and technologies to advance nanovaccine development". Advanced Drug Delivery Reviews 172 (2021): 148-182. https://doi.org/10.1016/j.addr.2021.03.001.
    10.1016/j.addr.2021.03.001
  6. Barbara Carreira; Rita C. Acúrcio; Ana I. Matos; Carina Peres; Sabina Pozzi; Daniella Vaskovich-Koubi; Ron Kleiner; et al. "Nanomedicines as Multifunctional Modulators of Melanoma Immune Microenvironment". Advanced Therapeutics 4 1 (2021): 2000147-2000147. https://doi.org/10.1002/adtp.202000147.
    10.1002/adtp.202000147
  7. Florindo, H.F.; Kleiner, R.; Vaskovich-Koubi, D.; Acúrcio, R.C.; Carreira, B.; Yeini, E.; Tiram, G.; Liubomirski, Y.; Satchi-Fainaro, R.. "Immune-mediated approaches against COVID-19". Nature Nanotechnology 15 8 (2020): 630-645. http://www.scopus.com/inward/record.url?eid=2-s2.0-85087808917&partnerID=MN8TOARS.
    10.1038/s41565-020-0732-3
  8. Acúrcio, R.C.; Scomparin, A.; Satchi-Fainaro, R.; Florindo, H.F.; Guedes, R.C.. "Computer-aided drug design in new druggable targets for the next generation of immune-oncology therapies". Wiley Interdisciplinary Reviews: Computational Molecular Science 9 3 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85055700780&partnerID=MN8TOARS.
    No prelo • 10.1002/wcms.1397
  9. Acúrcio, R.C.; Leonardo-Sousa, C.; García-Sosa, A.T.; Salvador, J.A.; Florindo, H.F.; Guedes, R.C.. "Structural insights and binding analysis for determining the molecular bases for programmed cell death protein ligand-1 inhibition". MedChemComm 10 10 (2019): 1810-1818. http://www.scopus.com/inward/record.url?eid=2-s2.0-85073807956&partnerID=MN8TOARS.
    10.1039/c9md00326f
  10. Goncalves, J.; Santos, M.; Acurcio, R.; Iria, I.; Gouveia, L.; Matos Brito, P.; Catarina Cunha-Santos, A.; et al. "Antigenic response to CT-P13 and infliximab originator in inflammatory bowel disease patients shows similar epitope recognition". Alimentary Pharmacology & Therapeutics 48 5 (2018): 507-522. http://dx.doi.org/10.1111/apt.14808.
    No prelo • 10.1111/apt.14808
  11. Acúrcio, R.C.; Scomparin, A.; Conniot, J.; Salvador, J.A.R.; Satchi-Fainaro, R.; Florindo, H.F.; Cardoso Guedes, R.. "Structure-function analysis of immune checkpoint receptors to guide emerging anticancer immunotherapy". Journal of Medicinal Chemistry (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85050352057&partnerID=MN8TOARS.
    10.1021/acs.jmedchem.8b00541
  12. Soengas, R.G.; Rodríguez-Solla, H.; Díaz-Pardo, A.; Acúrcio, R.; Concellõn, C.; Del Amo, V.; Silva, A.M.S.. "General preparation of 1-substituted (E)-1,3-dienes under mild conditions". European Journal of Organic Chemistry 2015 11 (2015): 2524-2530. http://www.scopus.com/inward/record.url?eid=2-s2.0-85027934404&partnerID=MN8TOARS.
    10.1002/ejoc.201403623
  13. Acúrcio, Rita; Soengas, Raquel; Silva, Artur. "Indium-Mediated Debromination of gem-Bromonitroalkanes under Mild Conditions in Aqueous Medium". Synlett 25 11 (2014): 1561-1564. http://dx.doi.org/10.1055/s-0033-1339030.
    10.1055/s-0033-1339030
  14. Soengas, R.G.; Acúrcio, R.; Silva, A.M.S.. "Preparation of indium nitronates and their Henry reactions". Organic and Biomolecular Chemistry 12 43 (2014): 8593-8597. http://www.scopus.com/inward/record.url?eid=2-s2.0-84907966288&partnerID=MN8TOARS.
    10.1039/c4ob01468e
  15. Soengas, R.G.; Acúrcio, R.C.; Silva, A.M.S.. "Recent developments in the chemistry of gem-halonitro compounds". European Journal of Organic Chemistry 2014 29 (2014): 6339-6359. http://www.scopus.com/inward/record.url?eid=2-s2.0-84957882401&partnerID=MN8TOARS.
    10.1002/ejoc.201402043
  16. Acúrcio, R.C.; Soengas, R.G.; Almeida Paz, F.A.; Silva, A.M.S.. "Stereoselective synthesis of orthogonally protected 1,2-diaminoinositols from d -mannose". Synlett 25 15 (2014): 2217-2220. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905326785&partnerID=MN8TOARS.
    10.1055/s-0034-1378545
Poster em conferência
  1. Cordeiro, Jéssica; CONEJOS-SANCHEZ, INMACULADA; Acúrcio, Rita C; Moura, Liane I F; María J. Vicente; Helena F Florindo. Autor correspondente: Helena F Florindo. "Nano-immunotherapy to modulate immune cells in pancreatic cancer". Trabalho apresentado em "O Futuro Hoje: Novas Terapêuticas Moleculares e Biológicas¿, 2023.
  2. Carreira, Barbara; Acúrcio, Rita C; Pozzi, Sabina; Moura, Liane I F; Matos, Ana I; Peres, Carina; Kleiner, Ron; et al. Autor correspondente: Helena F Florindo. "Translational nanotechnology-based cancer vaccine to re-educate host immune response against melanoma brain metastases.". Trabalho apresentado em 4th SPLC-CRS Young Scientists Meeting: Delivering Science, Bridging Opportunities, 2023.
  3. Carreira, Barbara; Acúrcio, Rita C; Pozzi, Sabina; Moura, Liane I F; Ana I. Matos; Kleiner, Ron; Vaskovich-Koubi, Daniella; et al. Autor correspondente: Helena F Florindo. "Translational nanotechnology-based cancer nanovaccine to re-educate host immune response against melanoma brain metastases". Trabalho apresentado em Gordon Research Conference on Cancer Nanotechnology and Gordon Research Seminar on Cancer Nanotechnology, 2023.
  4. Carreira, Bárbara; Rita Acúrcio; Sabina Pozzi; Moura, Liane I F; Peres, Carina; Fernandes, Adelaide; Xapelli Sara; Satchi-Fainaro, Ronit; Helena F Florindo. "Precision Nanomedicine-based Immunotherapy to Overcome Immunosuppression Against Metastatic Melanoma.". Trabalho apresentado em Champalimaud Research Symposium: Tumor Microenvironment (from cancer initiation to metastasis), 2022.
  5. Sousa, Carlota; Rita Acúrcio; Guedes, Rita; Helena F Florindo. Autor correspondente: Sousa, Carlota. "In silico approaches to the identification of small molecules for immuno-oncology therapy.". Trabalho apresentado em 5th MCQUL (5º encontro do Colégio de Química UL), 2022.
  6. Sousa, Carlota; Rita Acúrcio; Helena F Florindo; Guedes, Rita. "Computational approaches to discovery small molecules for immuno-oncology therapies.". Trabalho apresentado em 13th iMed.ULisboa Postgraduate Students meeting, 2022.
  7. Rita Acúrcio; Nicole Mendes; Carreira, Bárbara; Ana I. Matos; Peres, Carina; María Jesus Vicent; Satchi-Fainaro, Ronit; Helena F Florindo. "Unlocking Pancreatic Cancer to Nano-Immunotherapy". Trabalho apresentado em EACR 2022 Congress - Innovative Cancer Science: Translating Biology to Medicine, 2022.
  8. Sousa, Carlota; Rita Acúrcio; Helena F Florindo; Guedes, Rita. "Discovery of the next generation of (multi-targeting) small molecules against cancer-related immunosuppressive players". Trabalho apresentado em Encontro Ciência 2022, 2022.
  9. Carreira, Bárbara; Acúrcio, Rita C; Liane I. Moura; Ana I. Matos; Sabina Pozzi; Adelaide Fernandes; Sara Xapelli; Ronit Satchi-Fainaro; Helena F Florindo. Autor correspondente: Carreira, Bárbara. "Precision Nanomedicine-based to Regulate Immunsuppression Against Metastatic Melanoma.". Trabalho apresentado em 12th iMed.ULisboa Postgraduate Students Meeting, 2021.
  10. Carreira, Barbara; Acúrcio, Rita C; Pozzi, Sabina; Moura, Liane I F; Ana I. Matos; Satchi-Fainaro, Ronit; Helena F Florindo. Autor correspondente: Helena F Florindo. "Precision Multifunctional Nanomedicines to Regulate Immunosuppression Against Melanoma Brain Metastasis". Trabalho apresentado em Cutaneous Melanoma: From Where to Where?,, 2021.
  11. Carreira, Bárbara; Acúrcio, Rita C; Adva Krivitsky; Elges Pisarevsky; Ana I. Matos; João M. Conniot; Anna Scomparin; Ronit Satchi-Fainaro; Helena F Florindo. Autor correspondente: Carreira, Bárbara. "Precision Nanomedicine-based Therapeutics to Regulate Immunosuppression Against Melanoma.". Trabalho apresentado em Basic and Translational Research Conference Tumor Microenvironment, 2020.
  12. Conniot, João; Scomparin, Anna; Carreira, Bárbara; Peres, Carina; Ana I. Matos; Acúrcio, Rita C; Moura, Liane I F; et al. "Functionalized nanobiomaterials as novel combination immunotherapies in cancer". Trabalho apresentado em EACR-AACR-ASPIC Conference: Tumor Microenvironment, 2020.
  13. Carreira, Barbara; Acúrcio, Rita C; Adva Krivitsky; Elges Pisarevsky; Ana I. Matos; Conniot, João; Scomparin, Anna; Satchi-Fainaro, Ronit; Helena F Florindo. Autor correspondente: Helena F Florindo. "Precision nanomedicine-based therapeutics to regulate immunosuppresion against melanoma". Trabalho apresentado em XIIIth Spanish-Portuguese Conference on Controlled Drug Delivery, 2020.
  14. Acúrcio, Rita C; Ana Paula Leandro; Helena F Florindo; Rita C Guedes. "Modulation of PD-1/PD-L1 interaction by small molecules". Trabalho apresentado em 11th iMed.ULisboa Postgraduate Students Meeting & 4th i3DU Meeting,, 2019.
  15. Carreira, Bárbara; Anna Scomparin; Adva Krivitsky; Ana I. Matos; Acúrcio, Rita C; João M. Conniot; Ronit Satchi-Fainaro; Helena F Florindo. Autor correspondente: Carreira, Bárbara. "Precision nanotechnology-based therapeutics to regulate tumor-immune cells crosstalk against melanoma.". Trabalho apresentado em 11th iMed.ULisboa Postgraduate Students Meeting & 4rd i3DU Meeting, 2019.
  16. Acúrcio, Rita C; Rita C Guedes; Helena F Florindo. "Computational strategy to modulate PD-1/PD-L1 interaction and activate T cells function through small molecules". Trabalho apresentado em 17th Annual Meeting of the Association for Cancer Immunotherapy, 2019.
  17. Carreira, Bárbara; Anna Scomparin; Adva Krivitsky; Ana I. Matos; Acúrcio, Rita C; João M. Conniot; Ronit Satchi-Fainaro; Helena F Florindo. Autor correspondente: Carreira, Bárbara. "Precision nanotechnology-based therapeutics to regulate tumor-immune cells crosstalk against melanoma.". Trabalho apresentado em 17th CIMT 2019 Annual Meeting, 2019.
  18. Acúrcio, Rita C; Helena F Florindo; Rita C Guedes. "New small-molecule immune checkpoint inhibitors: A new strategy in cancer immunotherapy,". Trabalho apresentado em 2nd Defense is the Best Attack – Immuno-Oncology Breakthroughs, 2019.
  19. Acúrcio, Rita C; Helena F Florindo; Rita C Guedes. "Small-molecule immune checkpoint inhibitors: New approach in cancer immunotherapy". Trabalho apresentado em 5th EFMC Young Medicinal Chemist Symposium (EFMC- YMCS), 2018.
  20. Acúrcio, Rita C; Helena F Florindo; Rita C Guedes. "Small-molecule immune system modulators: A step forward in cancer immunotherapy". Trabalho apresentado em 10th iMed.ULisboa Postgraduate Students Meeting & 3rd i3DU Meeting, 2018.
  21. Acúrcio, Rita C; Helena F Florindo; Rita C Guedes. "Discovery and development of small-molecule immune system modulators". Trabalho apresentado em European School of Medicinal Chemistry (XXXVIII Advanced Course of Medicinal Chemistry and “E.Duranti” National Seminar for PhD Students), 2018.
  22. Acúrcio, Rita C; Jorge AR Salvador; Helena F Florindo; Rita C Guedes. "Small-molecule immune checkpoint blockade: New approach in cancer immunotherapy". Trabalho apresentado em 3rd meeting of CQUL - Chemistry at ULisboa & 2018 Summer School,, 2018.
  23. Acúrcio, Rita C; Jorge AR Salvador; Helena F Florindo; Rita C Guedes. "Small-molecule immune system modulators: An in silico strategy for cancer immunotherapy". Trabalho apresentado em UL Chemistry PhD Meeting, 2nd Meeting of the CQUL (2ECQUL), 2017.
  24. Acúrcio, Rita C; Jorge AR Salvador; Rita C Guedes; Helena F Florindo. "Small-molecule immune system modulators: A step forward in cancer immunotherapy". Trabalho apresentado em Defense is the Best Attack – Immuno-Oncology Breakthroughs,, 2017.
  25. Acúrcio, Rita C; Jorge AR Salvador; Helena F Florindo; Rita C Guedes. "Structural insights on imune checkpoint blockade: An in silico strategy towards cancer immunotherapy". Trabalho apresentado em XXV Encontro Nacional da Sociedade Portuguesa de Química, 2017.
  26. Acúrcio, Rita C; Pedro Perdigão; Aida Duarte; Carlos São-José; Mariana Santa-Marta; José Moniz-Pereira; João Gonçalves. Autor correspondente: Acúrcio, Rita C. "HIV-1 latency reactivation by bacterial molecular agents derived from opportunistic infections". Trabalho apresentado em 7th iMed.ULisboa Postgraduate Students Meeting, 2015.
Resumo em conferência
  1. Acúrcio, Rita C; Sabina Pozzi; Carreira, Bárbara; Pojo, Marta; Sandra Casemiro; Paula Leandro; Adelaide Fernandes; et al. "Immune Checkpoint Blockade by Novel Small-Molecule Inhibitors Restores T Cell Function". Trabalho apresentado em 1st Spring Virtual Meeting on Medicinal Chemistry, 2021.
    Publicado • https://doi.org/10.3390/chemproc2021004001
  2. J. Gonçalves; M. Santos; Acúrcio, Rita C; I. Iria; P. Brito; A. C. Cunha Santos; A. Barbas; et al. Autor correspondente: J. Gonçalves. "P545 Antigenic response to CT-P13 and remicade in inflammatory bowel disease patients shows similar epitope recognition". Trabalho apresentado em 13th Congress of ECCO – European Crohn’s and Colitis Organisation, Vienna, 2018.
    Publicado • 10.1093/ecco-jcc/jjx180.672
Tese / Dissertação
  1. "Discovery and development of new small-molecule immune system modulators". Doutoramento, Universidade de Lisboa Faculdade de Farmácia, 2019.
  2. "Synthesis of new C-glycosyl derivatives". Mestrado, Universidade de Aveiro Unidade de Investigação de Química Orgânica Produtos Naturais e Agroalimentares, 2014.

Propriedade Intelectual

Patente
  1. Ronit Satchi; Helena F Florindo; Guedes, Rita; Acúrcio, Rita C. 2022. "Modulators of pd-l1/pd-1 interaction and uses thereof". Israel.
    Permitida
Pedido provisório de patente
  1. 2021. "Small molecules as modulators of PD-L1/PD-1 interaction".
    Protegido

Outros

Outra produção
  1. Brain endothelial STING1 activation by Plasmodium-sequestered heme promotes cerebral malaria via type I IFN response. 2022. Pais, T.F.; Ali, H.; da Silva, J.M.; Duarte, N.; Neres, R.; Chhatbar, C.; Acúrcio, R.C.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85130863683&partnerID=MN8TOARS.
    10.1101/2022.02.14.480268
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2023/02/06 Intranasal nanovaccine elicits robust humoral- and mucosalimmunity against SARS-CoV-2 4th SPLC-CRS Young Scientists Meeting
SPLC-CRS Local Chapter (Porto, Portugal)
2022/11/16 Immune checkpoint blockade by novel small-molecule inhibitors restores T cell function 6ª Conferência da RedeSAÚDE
RedeSAÚDE (Lisboa, Portugal)
2022/07/13 Intranasal multifunctional nanovaccine elicits robust immunity against SARS-CoV-2 CRS 2022 Annual Meeting & Expo
Controlled Release Society (CRS) (Montreal, Canadá)
2022/07 Intranasal multifunctional nanovaccine elicits robust immunity against SARS-CoV-2 CRS 2022 Annual Meeting & Expo
(Montreal, Canadá)
2022/05/02 Deciphering pancreatic tumor microenvironment crosstalk with flow cytometry Full Spectrum Flow Cytometry Course
Palex (Porto, Portugal)
2022/01/27 Peptide nano-vaccine against SARS-CoV-2 infection XVth Spanish Portuguese Conference on Controlled Drug Delivery
Spanish Portuguese Conference on Controlled Drug Delivery (Tenerife, Espanha)
2021/11/30 Precision Nanomedicine-based Immunotherapy to Overcome Immunosupression Against Melanoma Brain Metastasis. 5ª conferência da redeSAÚDE
(Lisbon, Portugal)
2021/10/15 Precision Multifunctional Nanomedicines to Regulate Immunsuppression Against Melanoma Brain Metastasis. Cutaneous Melanoma: From where to where?
Liga Portuguesa Contra o Cancro (LPCC) (Lisbon, Portugal)
2020/01/24 Precision Nanomedicine-based Therapeutics to Regulate Immunosuppression Against Melanoma Spanish-Portuguese XIIIth Spanish-Portuguese Conference on Controlled Drug Delivery
(Santiago de Compostela, Espanha)
2018/09/03 New small-molecule immune checkpoint inhibitors: A step forward in cancer immunotherapy XXV EFMC International Symposium on Medicinal Chemistry (EFMC-ISMC)
(Liubliana, Eslovénia)
2018/05/16 New small-molecule immune system modulators towards cancer immunotherapy 6th Portuguese Young Chemistry Meeting (PYCheM)
(Setúbal , Portugal)
2017/12/04 Small-molecule immune system modulators: An in silico strategy towards cancer immunotherapy CQUL - UL Chemistry PhD Meeting (2ECQUL)
(Lisboa, Portugal)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2022/01 - Atual FAK impact on lymphatic vasculature in metastatic breast cancer
Coorientador de Raquel Gouveia
M.Sc. in BioPharmaceutical Sciences (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/09 - 2022/12/13 Regulating Immune Response Against Pancreatic Cancer
Coorientador de Nicole Mendes
 M.Sc. in BioPharmaceutical Sciences (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/09 - 2022/07/19 Deciphering melanoma stroma to improve immunotherapy efficacy
Coorientador de Jéssica Luís
 Pharmaceutical Sciences (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2022/02 - 2022/06/30 Assessment of P32 and Cathepsin S role in Pancreatic Cancer
Coorientador de Ana Marta Nunes
 Pharmaceutical Sciences (Curso de aperfeiçoamento / especialização)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/09 - 2020/07 Small molecules for cancer immunotherapy: A melanoma approach
Coorientador
 M.Sc. in BioPharmaceutical Sciences (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2018/11/11 - 2018/11/16 FLx Flow - Flow Cytometry Course covered basic and advanced cytometry topics and comprised lectures and practical modules taught by national and international experts in the field. Cytometry applications offered at all levels, targeted at both beginners.
Outro
 FLx Flow - Flow Cytometry Course
Instituto Gulbenkian de Ciência, Portugal
2018/07/01 - 2018/07/05 XXXVIII Advanced Course of Medicinal Chemistry and E.Duranti National Seminar for PhD Students
Outro
 XXXVIII Advanced Course of Medicinal Chemistry and E.Duranti National Seminar for PhD Students
European Federation for Medicinal Chemistry, Suiça
2018/06/18 - 2018/06/22 MedChemTrain Summer School
Outro
 Frontiers in Medicinal Chemistry - MedChemTrain Summer School
Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2017/06/12 - 2017/06/16 MedChemTrain Summer School
Outro
 Frontiers in Medicinal Chemistry - MedChemTrain Summer School
Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016/06/20 - 2016/06/24 MedChemTrain Summer School
Outro
 Frontiers in Medicinal Chemistry - MedChemTrain Summer School
Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2021/02/26 Small-molecules for Cancer Immunotherapy: A melanoma approach
Arguente
 Lara Inês Silva Serronha (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2021/01/31 - Atual Drug Delivery and Translational Research Springer Nature (New York, US)

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2023/04/09 - Atual Integrated Master in Pharmaceutical Sciences - Curricular Unit Pharmaceutical Technology III Integrated Master in Pharmaceutical Sciences (Mestrado integrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2022/02 - Atual Integrated Master in Pharmaceutical Sciences - Curricular Unit Pharmaceutical Technology III Pharmaceutical Sciences (Mestrado integrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/03/22 - 2023/03/22 PhD and Postgraduate Advanced Course "ADVANCED DRUG DELIVERY" at Faculty of Pharmacy, University of Lisbon. Regulation of cancer immunity using advanced nanodelivery systems PhD and Postgraduate Advanced Course "ADVANCED DRUG DELIVERY"¿ (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Lisboa Faculdade de Farmácia, Portugal

Membro de associação

Nome da associação Tipo de participação
2022/01 - Atual Spanish-Portuguese Local Chapter Controlled Release Society Member
2017 - Atual European Association for Cancer Research (EACR) Member
2016 - Atual Sociedade Portuguesa de Química Member
2016 - Atual European Federation for Medicinal Chemistry (EFMC) Member

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2021 - Atual PhD Thesis Committee - PhD Candidate: Silvestre Isidoro Universidade de Lisboa Faculdade de Farmácia, Portugal
2022/12/15 - 2022/12/15 Jury member of the curricular unit Project III of Integrated Master's in Pharmaceutical Sciences (MICF) at Universidade de Lisboa, Faculdade de Farmácia. Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/04/26 - 2021/04/26 Jury member of first-year report. Project: Discovery of multi-targeting small-molecules against cancer-related immunosuppressive players Candidate: Carlota Miguel Leonardo de Sousa PhD in Pharmacy Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/12/17 - 2020/12/17 Jury member of the curricular unit Project III of Integrated Master's in Pharmaceutical Sciences (MICF) at Universidade de Lisboa, Faculdade de Farmácia. Universidade de Lisboa Faculdade de Farmácia, Portugal

Tutoria

Tópico Nome do aluno
2022/12/13 - 2023/01/30 Regulação da Resposta Imunológica em Melanoma através da Modulação de Fibroblastos Associados ao Cancro e da Tirosina Quinase de Adesão Focal Camila Silva
Distinções

Prémio

2023 Best Oral Communication
SPLC-CRS Local Chapter, Espanha
2019 Travel Grant for Congress "17th Annual Meeting of the Association for Cancer Immunotherapy", 21-23 May, 2019, Mainz, Germany.
Association for Cancer Immunotherapy , Alemanha
2019 Inclusiveness Target Countries (ITC) Conference Grants
European Cooperation in Science and Technology, Bélgica
2018 Travel Grant for "3rd MuTaLig COST Action Training School"
European Cooperation in Science and Technology, Bélgica
2018 Travel Grant to "European School of Medicinal Chemistry ESMEC XXXVIII Advanced Course of Medicinal Chemistry and Seminar for PhD students Urbino, Palazzo Battiferri, July 1-5, 2018"
European Federation for Medicinal Chemistry, Suiça
2017 Travel Grant for Congress "Defence is the best attack: Immuno-Oncology Breakthroughs", 9-11 October, 2017, Barcelona.
European Association For Cancer Research, Reino Unido

Outra distinção

2020 Nature Nanotechnology Cover (August 2020)
2018 Top 3 Project BioSolveIT Challenge 2018
BioSolveIT GmbH, Alemanha