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Dora Brites was graduated in Pharmacy in 1976, received her PhD degree in Biochemistry in 1988 and habilitation in Biological Sciences in in 2004 from the Universidade de Lisboa (ULisboa), Portugal. She is a senior scientist and head of the Neuroinflammation, Signaling and Neuroregeneration (NeuroIn) laboratory at the Research Institute for Medicines of the Faculty of Pharmacy of ULisboa. Dora Brites was/is principal investigator of 18 funded national and international projects to investigate the spread of neuroinflammation in Alzheimer's disease (AD) and Amyotrophic Lateral Sclerosis (ALS), together with the early priming in brain aging disorders. Dora Brites is an expert in neuronal and glial subtype categorization, exosome biology and miRNA modulation for regenerative technologies, using reliable 2D/3D disease models, including 'organ-on-a-ship' systems and patient-derived cells by reprogramming technologies. In recent work, the lab has been using astrocytes directly converted/reprogrammed from patient fibroblasts and iPSC-derived microglia, neurons, and astrocytes as disease models to explore the role of these cells in neuroinflammation and their regional pathological diversity. In terms of scientific contributions, she recently identified a set of inflammatory-associated miRNAs as determining glia polarization and neurodegeneration and that their regulation is key to halt AD and ALS disease progression. Her current research interests are focused on homeostatic imbalance and paracrine signaling dysregulation in AD and ALS, with the final goal of identifying new targets, early disease biomarkers and generating innovative therapies using bioreactors and miRNA-engineered exosomes for translational and personalized regenerative/reparative medicines. Dora Brites is author of more than 200 publications (h=48) that increased the current knowledge in neurodevelopmental and age-related disease mechanisms. Dora Brites received the Santa Casa prize in 2015 for developing an autologous exosome-based therapy to deliver neuroprotective cargoes in ALS and was the Nacional PI of the European Joint Programme for Neurodegenerative Diseases (JPND) for developing improved models for studying AD (2017-2020). Dora Brites has successfully supervised more than 30 Post-Doctoral researchers and PhD students and more than 50 master thesis. Dora Brites is Member of the Coordinating Board of RedeSAÚDE (ULisboa), Portuguese Glial Network, Coordinator Council and Executive Director of Mind-Brain College, Alzaforum Directory and Emeritus Investigator of the ULisboa.
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Identificação

Identificação pessoal

Nome completo
Dora Brites

Nomes de citação

  • Brites, Dora

Identificadores de autor

Ciência ID
921C-9B98-2867
ORCID iD
0000-0002-3024-9777
Researcher Id
M-8293-2013
Scopus Author Id
7004026610

Endereços de correio eletrónico

  • dbrites@ff.ul.pt (Profissional)

Telefones

Telefone
  • 217946450 (Profissional)

Moradas

  • Faculdade de Farmácia da Universidade de Lisboa - Av. Prof. Gama Pinto, 1649-003, Lisboa, Lisboa, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Inglês Utilizador independente (B1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador independente (B1)
Francês Utilizador independente (B1) Utilizador proficiente (C1) Utilizador independente (B1) Utilizador independente (B1)
Espanhol; Castelhano Utilizador elementar (A1) Utilizador independente (B1) Utilizador elementar (A1) Utilizador elementar (A1)
Italiano Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1)
Formação
Grau Classificação
2004
Concluído
 Farmácia (Título de Agregado)
Especialização em Biological Sciences
Universidade de Lisboa Faculdade de Farmácia, Portugal
1988/07/25
Concluído
 Farmácia (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Bilirrubina. Contribuição para o estudo do mecanismo da sua acção tóxica com particular relevância para o período neonatal precoce" (TESE/DISSERTAÇÃO)
 Aprovada por unanimidade com distinção e louvor
1976
Concluído
 Ciências Farmacêuticas (Mestrado integrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
 14 valores
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2007 - 2021 Investigador Coordenador (carreira) (Investigação) Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
1996/01/01 - 2006/12/31 Investigador principal (carreira) (Investigação) Universidade de Lisboa Faculdade de Farmácia, Portugal
1988/01/01 - 1996/12/31 Assistente de Investigação (carreira) (Investigação) Universidade de Lisboa Faculdade de Farmácia, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2006 - 2021 Professor Catedrático (Docente Universitário) Universidade de Lisboa Faculdade de Farmácia, Portugal
2013 - 2016 Professor Catedrático Convidado (Docente Universitário) Universidade de Lisboa Faculdade de Farmácia, Portugal
1988 - 2006 Professor Auxiliar Convidado (Docente Universitário) Universidade de Lisboa Faculdade de Farmácia, Portugal

Cargos e Funções

Categoria Profissional
Instituição de acolhimento 		Empregador
2021/09 - Atual Emeritus Researcher Faculdade de Farmácia da Universidade de Lisboa, Portugal
Faculdade de Farmácia da Universidade de Lisboa, Portugal
2021 - Atual Promoter of the Clinical Strand Working Group on Neurodegenerative Diseases - Axis III at the Universidade de Lisboa Faculdade de Farmácia da Universidade de Lisboa, Portugal
Universidade de Lisboa, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2021 - Atual LEADER OF THE NEUROINFLAMMATION, SIGNALING AND NEUROREGENERATION LAB Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2015 - Atual Member of the Coordinator Council and of the Executive Director of Mind-Brain College Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 - Atual Founder and Member of the Executive Committee of Portuguese Glial Network Rede Glial Poruguesa, Portugal
2006 - Atual HEAD BILIRUBIN AND BILE ACID LABORATORY (Public Services) Universidade de Lisboa Faculdade de Farmácia, Portugal
2019 - 2022 Secretary of the Assembly Table of the Portuguese Society of Biochemistry Universidade de Lisboa Faculdade de Farmácia, Portugal
2014/01/01 - 2021/01/04 Member of the Directive Board of the Doctoral Program in Integrative Neuroscience Universidade de Lisboa Faculdade de Farmácia, Portugal
2019 - 2021 Vice-President of the Scientific Council Universidade de Lisboa Faculdade de Farmácia, Portugal
2008/01/01 - 2021 LEADER - GROUP OF NEURON GLIA BIOLOGY IN HEALTH AND DISEASE Universidade de Lisboa Faculdade de Farmácia, Portugal
2003/09/01 - 2021 MEMBER OF THE SCIENTIFIC COUNCIL Universidade de Lisboa Faculdade de Farmácia, Portugal
2015/01/01 - 2018/01/04 Fiscal Committee Secretary of the Portuguese Society of Biochemistry Universidade de Lisboa Faculdade de Farmácia, Portugal
2014/01/01 - 2018/01/04 Member of the Mentorship Advisory Committee of the Doctoral i3DU Programme in Medicines and Pharmaceutical Innovation Universidade de Lisboa Faculdade de Farmácia, Portugal
2005/09/01 - 2014/03/20 VICE-PRESIDENT OF THE SCIENTIFIC COUNCIL Universidade de Lisboa Faculdade de Farmácia, Portugal
1996/01/01 - 2012/12/29 VICE-PRESIDENT OF THE PEDAGOGIC COUNCIL Universidade de Lisboa Faculdade de Farmácia, Portugal
1998/01/01 - 2006/07/01 LEADER - GROUP OF HEPATIC DYSFUNCTION AND BRAIN DAMAGE Universidade de Lisboa Faculdade de Farmácia, Portugal
2002/01/01 - 2004 VICE-PRESIDENT OF THE REPRESENTATIVE ASSEMBLY Universidade de Lisboa Faculdade de Farmácia, Portugal
1976/01/01 - 1998/12/31 CHEMIST-ANALYST Universidade de Lisboa Faculdade de Farmácia, Portugal
Projetos

Bolsa

Designação Financiadores
2021/10 - Atual Targeting TDP-43 with protein kinase inhibitors: an effective and measurable therapy for ALS
HR21-00931
Co-Investigador Responsável (Co-IR)
Caixabank SA
2021/01 - Atual Analyzing neuroimmune dysregulation in Alzheimer´s disease toward a therapy with miRNA-loaded exosomes
PTDC/MED-NEU/2382/2021
Investigador responsável
Fundação para a Ciência e a Tecnologia
2019 - 2022 Engineering hybrid exosomes as microRNAs nanocarriers to microglia in Amyotrophic Lateral Sclerosis
UID/DTP/04138/2019
Co-Investigador Responsável (Co-IR)
Faculdade de Farmácia da Universidade de Lisboa, Portugal
 Gilead Foundation
Concluído
2018/09 - 2022 New Psychoactive Substances - A Platform for Risk Assessment of Teens Brain
32515/02/SAICT/2017
Investigador responsável
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2018/08 - 2022 Development of an autologous exosome-based therapy by engineering microRNAs in microglia and motor-neurons using mice and human models of amyotrophic lateral sclerosis (ALS)
PTDC/MED-NEU/31395/2017
Investigador responsável
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
 Fundação para a Ciência e Tecnologia
Concluído
2018/07 - 2022 Thioredoxin Arrest to Reduce Glioblastoma: Ethylmercury and Thimerosal to target Cancer
31136/02/SAICT/2017
Investigador
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2016/01 - 2022 Exploring the impact of astrocyte-derived microvesicles for motor neuron degeneration and as vehicles to delivery neuroroprotective cargoes in Amyotrophic Lateral Sclerosis (ALS)
Programa de Investigação Científica em Esclerose Lateral Amiotrófica
Investigador responsável
Santa Casa da Misericórdia de Lisboa, Portugal
 Santa Casa da Misericórdia de Lisboa
Concluído
2019 - 2021 Dementia associated with HIV infection - study of the mechanisms infectious and inflammatory mediated by extracellular vesicles
PGG/035/2019
Co-Investigador Responsável (Co-IR)
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
 Gilead Sciences Lda
Concluído
2017 - 2019 Role of ectosomes in the spread of HIV infection into the CNS and in HIV-associated dementia pathogenesis
PGG/035/2019
Investigador responsável
Gilead Sciences Lda
Concluído
2016 - 2019 Role of ectosomes in the spread of HIV infection into the CNS and in HIV-associated dementia pathogenesis
PGG/018/2016
Investigador
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
 Gilead Sciences Lda
Em curso
2016/01 - 2018/12 Identification and assessment of new psychoactive substances: a European network
Grant JUST/2014/JDRUG/AG/DRUG
Investigador responsável
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
 Transnational projects in the area of EU drugs policy
Concluído
2016/01 - 2018/12 Generation of Improved Cellular and Animal Models for Identification of Disease Phenotype and New Therapeutic Targets of Alzheimer’s Disease
JPCOFUND/0003/2015
Investigador responsável
JPco-fuND
2014/03/01 - 2015 Decoding the regulation of microglia phenotype by microRNAs in Alzheimer's Disease
info:eu-repo/grantAgreement/FCT/3599-PPCDT/134028/PT
EXPL/NEU-NMC/1003/2013
Investigador
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2010 - 2014 Are microglia a new potential pharmacological target in amyotrophic lateral sclerosis (ALS)?
PTDC/SAU-FAR/118787/2010
Investigador responsável
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
 Ministério da Ciência Tecnologia e Ensino Superior
Concluído
2007/07/01 - 2010 Study of the blood-brain barrier disruption by neurotoxins and modulation by therapeutic agents in a human model: effects of bilirubin and endotoxin on brain microvascular endothelial cell monolayer integrity and protective role of bile acids
info:eu-repo/grantAgreement/FCT/3599-PPCDT/68819/PT
Investigador
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
 Fundação para a Ciência e a Tecnologia
2007/07/01 - 2010 Trophic actions of neurotrophic factors: dependency of adenosine A2A receptors co-activation
info:eu-repo/grantAgreement/FCT/3599-PPCDT/64126/PT
Investigador
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2007 - 2010 Uncovering the potential neurodevelopmental deficits in common neonatal conditions such as hyperbilirubinemia and inflammation
PTDC/SAU-NEU/64385/2006
Investigador responsável
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
 Fundação para a Ciência e a Tecnologia
2005/01/01 - 2008 Acute and long-term injury of bilirubin to nerve cells - Looking for sensors, susceptibilities and modulators
info:eu-repo/grantAgreement/FCT/3599-PPCDT/82303/PT
Investigador responsável
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2002 - 2005 Inflammatory response and signaling between neurons and astrocytes during cell injury by sepsis, hypoxia-ischemia and hyperbilirubinemia
POCTI/FCB/39906/2001
Investigador responsável
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2002 - 2005 Inflammatory response and signaling between neurons and astrocytes during cell injury by sepsis, hypoxia-ischemia and hyperbilirubinemia
POCTI/FCB/39906/2001
Investigador responsável
Fundação para a Ciência e a Tecnologia
1999 - 2001 Mechanisms of cell injury by glycochenodeoxycholic acid, bilirubin and amyloid beta-peptide
PRAXIS/PSAU/C/14311/1998
Investigador
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
1997 - 2000 Role of bilirubin species in the molecular mechanisms of cell membrane damage
PRAXIS/PSAU/C/SAU/127/96
Investigador responsável
Fundação para a Ciência e a Tecnologia
Concluído
1997 - 2000 Role of bilirubin species in the molecular mechanisms of cell membrane damage
PRAXIS/PSAU/C/SAU/127/96
 Fundação para a Ciência e a Tecnologia
1992 - 1996 Evaluation of cellular fragility indicators to bilirubin toxicity and contribution for preventing neonatal jaundice sequelae
PBIC/C/SAU/1570/92
Investigador responsável
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Concluído
1992 - 1996 Evaluation of cellular fragility indicators to bilirubin toxicity and contribution for preventing neonatal jaundice sequelae
PBIC/C/SAU/1570/92
 N/A
Produções

Publicações

Artigo em revista
  1. Susana García-Cerro; Ana Gómez-Garrido; Gonçalo Garcia; Benedicto Crespo-Facorro; Dora Brites. "Exploratory Analysis of MicroRNA Alterations in a Neurodevelopmental Mouse Model for Autism Spectrum Disorder and Schizophrenia". International Journal of Molecular Sciences (2024): https://doi.org/10.3390/ijms25052786.
    10.3390/ijms25052786
  2. Pereira, Patrick Douglas Corrêa; Diniz, Daniel Guerreiro; da Costa, Emanuel Ramos; Magalhães, Nara Gyzely de Morais; da Silva, Anderson de Jesus Falcão; Leite, Jéssica Gizele Sousa; Almeida, Natan Ibraim Pires; et al. "Genes, inflammatory response, tolerance, and resistance to virus infections in migratory birds, bats, and rodents". Frontiers in Immunology 14 (2023): http://dx.doi.org/10.3389/fimmu.2023.1239572.
    10.3389/fimmu.2023.1239572
  3. Santos Silva, E.; Rocha, S.; Candeias Ramos, R.; Coutinho, H.; Catarino, C.; Teixeira, F.; Henriques, G.; et al. "Bile acids profile and redox status in healthy infants". Pediatric Research (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85140460365&partnerID=MN8TOARS.
    10.1038/s41390-022-02350-y
  4. Gonçalo Garcia; Sara Pinto; Sofia Ferreira; Daniela Lopes; Maria João Serrador; Fernandes A; Ana R Vaz; et al. "Emerging Role of miR-21-5p in Neuron-Glia Dysregulation and Exosome Transfer Using Multiple Models of Alzheimer's Disease". Cells (2022): https://www.mdpi.com/2073-4409/11/21/3377.
    10.3390/cells11213377
  5. Marta Barbosa; Marta Santos; Nídia de Sousa; Sara Duarte-Silva; Ana Rita Vaz; António J. Salgado; Dora Brites. "Intrathecal Injection of the Secretome from ALS Motor Neurons Regulated for miR-124 Expression Prevents Disease Outcomes in SOD1-G93A Mice". Biomedicines (2022): https://doi.org/10.3390/biomedicines10092120.
    10.3390/biomedicines10092120
  6. Fabíola de Carvalho Chaves de Siqueira Mendes; Marina Negrão Frota de Almeida; Manoela Falsoni; Marcia Lorena Ferreira Andrade; André Pinheiro Gurgel Felício; Luisa Taynah Vasconcelos Barbosa da Paixão; Fábio Leite do Amaral Júnior; et al. "The Sedentary Lifestyle and Masticatory Dysfunction: Time to Review the Contribution to Age-Associated Cognitive Decline and Astrocyte Morphotypes in the Dentate Gyrus". International Journal of Molecular Sciences 23 11 (2022): 6342-6342. https://doi.org/10.3390/ijms23116342.
    10.3390/ijms23116342
  7. Cátia Gomes; Catarina Sequeira; Shibi Likhite; Cassandra N. Dennys; Stephen J Kolb; Pamela J. Shaw; Ana R Vaz; et al. "Neurotoxic Astrocytes Directly Converted from Sporadic and Familial ALS Patient Fibroblasts Reveal Signature Diversities and miR-146a Theragnostic Potential in Specific Subtypes". Cells (2022): https://www.mdpi.com/2073-4409/11/7/1186.
    10.3390/cells11071186
  8. Adelaide Fernandes; Cláudia Caldeira; Carolina Cunha; Elisabete Ferreiro; Ana Rita Vaz; Dora Brites. "Differences in Immune-Related Genes Underlie Temporal and Regional Pathological Progression in 3xTg-AD Mice". Cells (2022): https://doi.org/10.3390/cells11010137.
    10.3390/cells11010137
  9. Garcia, G.; Fernandes, A.; Stein, F.; Brites, D.. "Protective Signature of IFN-gamma-Stimulated Microglia Relies on miR-124-3p Regulation From the Secretome Released by Mutant APP Swedish Neuronal Cells". Frontiers in Pharmacology 13 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85130760459&partnerID=MN8TOARS.
    10.3389/fphar.2022.833066
  10. Paolicelli, R.C.; Sierra, A.; Stevens, B.; Tremblay, M.-E.; Aguzzi, A.; Ajami, B.; Amit, I.; et al. "Microglia states and nomenclature: A field at its crossroads". Neuron 110 21 (2022): 3458-3483. http://www.scopus.com/inward/record.url?eid=2-s2.0-85140895591&partnerID=MN8TOARS.
    10.1016/j.neuron.2022.10.020
  11. Loch-Neckel, G.; Matos, A.T.; Vaz, A.R.; Brites, D.. "Challenges in the Development of Drug Delivery Systems Based on Small Extracellular Vesicles for Therapy of Brain Diseases". Frontiers in Pharmacology 13 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85131558514&partnerID=MN8TOARS.
    10.3389/fphar.2022.839790
  12. Barros, C.; Barateiro, A.; Neto, A.; Soromenho, B.; Basto, A.P.; Mateus, J.M.; Xapelli, S.; et al. "S100B inhibition protects from chronic experimental autoimmune encephalomyelitis". Brain Communications 4 3 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85136096325&partnerID=MN8TOARS.
    10.1093/braincomms/fcac076
  13. Pomeshchik, Yuriy; Klementieva, Oxana; Gil, Jeovanis; Martinsson, Isak; Hansen, Marita Grønning; de Vries, Tessa; Sancho-Balsells, Anna; et al. "Human iPSC-derived hippocampal spheroids: An innovative tool for stratifying Alzheimer disease patient-specific cellular phenotypes and developing therapies". Stem Cell Reports 16 11 (2021): 2838. http://dx.doi.org/10.1016/j.stemcr.2021.10.003.
    Publicado • 10.1016/j.stemcr.2021.10.003
  14. Brites, Dora; Rui Silva 421A-BD8B-09B3. Autor correspondente: Brites, Dora. "Bilirubin neurotoxicity: a narrative review on long lasting, insidious, and dangerous effects". Pediatric Medicine 4 (2021): 34-34. http://dx.doi.org/10.21037/pm-21-37.
    10.21037/pm-21-37
  15. Leite, Amanda de Oliveira Ferreira; Bento Torres Neto, João; dos Reis, Renata Rodrigues; Sobral, Luciane Lobato; de Souza, Aline Cristine Passos; Trévia, Nonata; de Oliveira, Roseane Borner; et al. "Unwanted Exacerbation of the Immune Response in Neurodegenerative Disease: A Time to Review the Impact". Frontiers in Cellular Neuroscience 15 (2021): http://dx.doi.org/10.3389/fncel.2021.749595.
    10.3389/fncel.2021.749595
  16. Gonçalo Garcia; Sara Pinto; Mar Cunha; Adelaide Fernandes; Jari Koistinaho; Dora Brites. "Neuronal Dynamics and miRNA Signaling Differ between SH-SY5Y APPSwe and PSEN1 Mutant iPSC-Derived AD Models upon Modulation with miR-124 Mimic and Inhibitor". Cells 10 9 (2021): 2424-2424. https://doi.org/10.3390/cells10092424.
    10.3390/cells10092424
  17. Carvalho-Paulo, Dario; Bento Torres Neto, João; Filho, Carlos Santos; de Oliveira, Thais Cristina Galdino; de Sousa, Aline Andrade; dos Reis, Renata Rodrigues; dos Santos, Zaire Alves; et al. "Microglial Morphology Across Distantly Related Species: Phylogenetic, Environmental and Age Influences on Microglia Reactivity and Surveillance States". Frontiers in Immunology 12 (2021): http://dx.doi.org/10.3389/fimmu.2021.683026.
    10.3389/fimmu.2021.683026
  18. Ana Rita Vaz; Daniela Vizinha; Hermes Morais; Ana Rita Colaço; Gecioni Loch-Neckel; Marta Barbosa; Dora Brites. "Overexpression of miR-124 in Motor Neurons Plays a Key Role in ALS Pathological Processes". International Journal of Molecular Sciences (2021): https://doi.org/10.3390/ijms22116128.
    10.3390/ijms22116128
  19. Brites, Dora; Gomes, Cátia; Sequeira, Catarina; Gonçalves-Ribeiro, Joana; Pina, Carolina Campos; Carvalho, Luís A.; Moreira, Rui; et al. Autor correspondente: Brites, Dora. "Recovery of Depleted miR-146a in ALS Cortical Astrocytes Reverts Cell Aberrancies and Prevents Paracrine Pathogenicity on Microglia and Motor Neurons". Frontiers in Cell and Developmental Biology 9 (2021): http://dx.doi.org/10.3389/fcell.2021.634355.
    Publicado • 10.3389/fcell.2021.634355
  20. Siqueira Mendes, Fabíola de Carvalho Chaves de; Paixão, Luisa Taynah Vasconcelos Barbosa; Diniz, Daniel Guerreiro; Anthony, Daniel Clive; Brites, Dora; Diniz, Cristovam Wanderley Picanço; Sosthenes, Marcia Consentino Kronka. "Sedentary Life and Reduced Mastication Impair Spatial Learning and Memory and Differentially Affect Dentate Gyrus Astrocyte Subtypes in the Aged Mice". Frontiers in Neuroscience 15 (2021): http://dx.doi.org/10.3389/fnins.2021.632216.
    10.3389/fnins.2021.632216
  21. Pomeshchik, Y.; Klementieva, O.; Gil, J.; Martinsson, I.; Hansen, M.G.; de Vries, T.; Sancho-Balsells, A.; et al. "Erratum: Human iPSC-derived hippocampal spheroids: An innovative tool for stratifying Alzheimer disease patient-specific cellular phenotypes and developing therapies (Stem Cell Reports (2020) 15(1) (256–273), (S2213671120301922), (10.1016/j.stemcr.2020.06.001))". Stem Cell Reports 16 11 (2021): 2838-2838. http://www.scopus.com/inward/record.url?eid=2-s2.0-85118491121&partnerID=MN8TOARS.
    10.1016/j.stemcr.2021.10.003
  22. Figueira, I.; Garcia, G.; Pimpão, R.C.; Terrasso, A.P.; Costa, I.; Almeida, A.F.; Tavares, L.; et al. "Correction to: Polyphenols journey through blood-brain barrier towards neuronal protection (Scientific Reports, (2017), 7, 1, (11456), 10.1038/s41598-017-11512-6)". Scientific Reports 11 1 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85113180723&partnerID=MN8TOARS.
    10.1038/s41598-021-96179-w
  23. Brites, Dora. "S100B Impairs Oligodendrogenesis and Myelin Repair Following Demyelination Through RAGE Engagement.". Frontiers in cellular neuroscience (2020): https://europepmc.org/articles/PMC7500156.
    10.3389/fncel.2020.00279
  24. Dora Brites. "Regulatory function of microRNAs in microglia". Glia 68 8 (2020): 1631-1642. https://doi.org/10.1002/glia.23846.
    10.1002/glia.23846
  25. Brites, Dora. "Astrocyte regional diversity in ALS includes distinct aberrant phenotypes with common and causal pathological processes.". Experimental cell research (2020): https://doi.org/10.1016/j.yexcr.2020.112209.
    10.1016/j.yexcr.2020.112209
  26. Brites, Dora. "Microglia Susceptibility to Free Bilirubin Is Age-Dependent.". Frontiers in pharmacology (2020): https://europepmc.org/articles/PMC7381152.
    10.3389/fphar.2020.01012
  27. Brites, Dora. "Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies.". Stem cell reports (2020): https://europepmc.org/articles/PMC7363942.
    10.1016/j.stemcr.2020.06.001
  28. Brites, Dora. "Designer Cathinones N-Ethylhexedrone and Buphedrone Show Different In Vitro Neurotoxicity and Mice Behaviour Impairment.". Neurotoxicity research (2020): https://doi.org/10.1007/s12640-020-00229-6.
    10.1007/s12640-020-00229-6
  29. Carla Ferreira; Ana Rita Vaz; Pedro R. Florindo; Álvaro Lopes; Dora Brites; Alexandre Quintas. "Development of a high throughput methodology to screen cathinones’ toxicological impact". Forensic Science International 298 (2019): 1-9. https://doi.org/10.1016/j.forsciint.2019.02.022.
    10.1016/j.forsciint.2019.02.022
  30. Braga, C.; Vaz, A.R.; Oliveira, M.C.; Matilde Marques, M.; Moreira, R.; Brites, D.; Perry, M.J.. "Targeting gliomas with triazene-based hybrids: Structure-activity relationship, mechanistic study and stability". European Journal of Medicinal Chemistry 172 (2019): 16-25. http://www.scopus.com/inward/record.url?eid=2-s2.0-85063613128&partnerID=MN8TOARS.
    10.1016/j.ejmech.2019.03.048
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Capítulo de livro
  1. Vaz, Sandra H.; Pinto, Sara; Sebastião, Ana M.; Brites, Dora. "Astrocytes in Amyotrophic Lateral Sclerosis". In Amyotrophic Lateral Sclerosis, editado por Toshiyuri Araki, 35-54. Exon Publications, 2021.
    Publicado • 10.36255/exonpublications.amyotrophiclateralsclerosis.astrocytes.2021
  2. Vaz AR; Brites, Dora; Gomes, C.; Cunha, C.. "Astrocytes in Amyotrophic Lateral Sclerosis: Harmful Effects and Strategies to Afford Neuroprotection". In New Developments in Astrocytes Research, 67-111. Nova Science Publishers, 2016.
    Publicado
  3. Brites, Dora. "Urso-, Glycoursodeoxycholic and Tauroursodeoxycholic Acids: From Basic Research to Clinical Applications in CNS Disorders". In Frontiers in Bioactive Compounds, 330-366. BENTHAM SCIENCE PUBLISHERS, 2016.
    Publicado • 10.2174/9781681086071118060008
  4. Palmela, I.; Correia, L.; Silva RFM; Sasaki, H.; Kim, KS; Brites, Dora; Brito, Maria A.. "Hydrophilic bile acids protect human blood-brain barrier endothelial cells from disruption by unconjugated bilirubin: an in vitro study". In Ontogeny and Phylogeny of Brain Barrier Mechanisms, 335-345. Frontiers Media SA, 2016.
    Publicado
  5. Barateiro, A.; Santos, G.; Afonso, V.; Brites, D.; Fernandes, A.. "Role of S100B on oligodendrocyte physiology and pathology". In Evolutionary Biology, Cell-Cell Communication, and Complex Disease. 2015.
    10.1002/9781634638722.ch5
  6. Brites, Dora; Brites, D.; Gomes, C.; Pinheiro, R.; Falcão, A.S.. "New insights in the pro-and anti-neurogenic interventions of microglia and their association to gliomas". In Evolutionary Biology, Cell-Cell Communication, and Complex Disease. 2015.
  7. Falcão, AS; Gomes, C; Brites, Dora. "Role of ABC transporters in the regulation of neural stem cell biology: implications on CNS diseases". In Evolutionary Biology, Cell-Cell Communication, and Complex Disease, 73-112. Nova Science Publishers, 2015.
    Publicado
  8. Fernandes, A; Vaz, AR; Brites, Dora. "S100B as a Candidate Biomarker and Therapeutic Target in Neurodegenerative Disorders". In S100B: Serum Detection, Functions andClinical Significance, 33-61. Nova Science Publishers, 2015.
    Publicado
  9. Brites, Dora; Bhutani, V. "Pathways involving bilirubin and other brain-injuring agents for cerebral palsy. In: Cerebral Palsy". In Cerebral Palsy, 131-150. Mac Keith Press, 2014.
    Publicado
  10. Palmela, I.; Brites, D.; Brito, M.A.. "Blood -brain barrier in health and disease". In Advances in Medicine and Biology, 201-218. Nova Science Publishers, 2012.
    Publicado

Outros

Outra produção
  1. S100B as a potential biomarker and therapeutic target in multiple sclerosis. Multiple sclerosis (MS) pathology is characterized by neuroinflammation and demyelination. Recently, the inflammatory molecule S100B was identified in cerebrospinal fluid (CSF) and serum of MS patients. Although seen as an astrogliosis marker, lower/physiological levels of S100B are involved in oligodendrocyte differentiation/maturation. Nevertheless, increased S100B levels released upon injury ma. 2016. Barateiro, Andreia; Afonso, Vera; Santos, Gisela; Cerqueira, João José; Brites, Dora; Horssen, Jack van; Fernandes, Adelaide. http://hdl.handle.net/1822/46284.
    10.1007/s12035-015-9336-6
  2. Identification of a novel deletion in UDP-glucuronosyltransferase gene in a patient with Crigler–Najjar syndrome type I. Letter to the Editor. 2009. Costa, Elísio; Santos, Emília Vieira Rosário dos; Lopes, Ana Isabel; Saldanha, Maria Joana; Brites, Dora; Vieira, Emília; Costa, Elisio; Vieira, Emilia; dos Santos, Rosario. http://hdl.handle.net/10400.14/3778.
    http://dx.doi.org/10.1016/j.bcmd.2008.12.004
  3. Bilirubin as a Determinant for Altered Neurogenesis, Neuritogenesis, and Synaptogenesis. Elevated levels of serum unconjugated bilirubin (UCB) in the first weeks of life may lead to long-term neurologic impairment. We previously reported that an early exposure of developing neurons to UCB, in conditions mimicking moderate to severe neonatal j. - Fundacao para a Ciencia e a Tecnologia (FCT) ; FEDER [POCI/SAU-MMO/55955/2004, PTDC/SAU-NEU/64385/2006, SFRH/BPD/26390/2006, SFRH/BPD/26381/2. 2009. Fernandes, Adelaide; Falcao, Ana Sofia; Abranches, Elsa; Bekman, Evguenia; Henrique, Domingos; Lanier, Lorene M.; Brites, Dora. http://hdl.handle.net/10451/21532.
    http://dx.doi.org/10.1002/dneu.20727
  4. Automated Analysis of NeuronJ Tracing Data. Studies of neuronal differentiation in vitro often involve tracing and analysis of neurites. Neuron) (Meijering et al., Cytometry Part A 2004;58A:167-176; http://www.imagescience.org/meijering/software/neuronj/) is a program that can be used for semi-auto. - NIH [RO1NS049178]; Fundacao pare a Ciencia e a Tecnologia (FCT), Lisbon, Portugal [PTDC/SAU-NEU/64385/2006, SFRH/BPD/26390/2006]; FEDER. - Gr. 2009. Popko, Jonathan; Fernandes, Adelaide; Brites, Dora; Lanier, Lorene M.. http://hdl.handle.net/10451/21679.
    http://dx.doi.org/10.1002/cyto.a.20660
  5. Contribution of Inflammatory Processes to Nerve Cell Toxicity by Bilirubin and Efficacy of Potential Therapeutic Agents. Hyperbilirubinemia is a common condition in neonatal life, where elevated levels of unconjugated bilirubin (UCB) may lead to adverse neurologic outcomes, namely in the presence of inflammatory features. In this review, we summarize recent concepts on UCB. - Fundacao para a Ciencia e a Tecnologia (FCT), Lisbon, Portugal [POCI/SAU-MMO/55955/2004, PTDC/SAU-NEU/64385/2006, SFRH/BPD/26390/2006]; FEDER.. 2009. Fernandes, Adelaide; Brites, Dora. http://hdl.handle.net/10451/21533.
  6. Bilirubin injury to neurons: contribution of oxidative stress and rescue by glycoursodeoxycholic acid. It is well established that high levels of unconjugated bilirubin (UCB) can be toxic to the central nervous system, and oxidative stress is emerging as a relevant event in the mechanisms of UCB encephalopathy. In contrast, the hydrophilic bile acid, ursod. 2008. Brito, Maria A.; Lima, Silvia; Fernandes, Adelaide; Falcao, Ana S.; Silva, Rui F. M.; Butterfield, D. Allan; Brites, Dora. http://hdl.handle.net/10451/21556.
    http://dx.doi.org/10.1016/j.neuro.2007.11.002
  7. Unconjugated bilirubin differentially affects the redox status of neuronal and astroglial cells. We investigated whether nerve cell damage by unconjugated bilirubin (UCB) is mediated by oxidative stress and ascertained the neuronal and astroglial susceptibility to injury. Several oxidative stress biomarkers and cell death were determined following in. 2008. Brito, Maria A.; Rosa, Alexandra I.; Falcao, Ana S.; Fernandes, Adelaide; Silva, Rui F. M.; Butterfield, D. Allan; Brites, Dora. http://hdl.handle.net/10451/21555.
    http://dx.doi.org/10.1016/j.nbd.2007.07.023
  8. Astrocytes modulate neuronal injury during hyperbilirubinemia. 2007. Falcaeo, Ana S.; Silva, Sandra L.; Fernandes, Adelaide; Vaz, Ana R.; Silva, Rui F. M.; Brito, Maria A.; Brites, Dora. http://hdl.handle.net/10451/20959.
  9. Glycoursodeoxycholic acid and interleukin-10 modulate the reactivity of rat cortical astrocytes to unconjugated bilirubin. The pathogenesis of bilirubin encephalopathy seems to result from accumulation of unconjugated bilirubin (UCB) within the brain. We have recently demonstrated that UCB causes astroglial release of proinflammatory cytokines and glutamate, as well as cell d. 2007. Fernandes, Adelaide; Vaz, Ana Rita; Falcao, Ana S.; Silva, Rui F. M.; Brito, Maria A.; Brites, Dora. http://hdl.handle.net/10451/21552.
  10. Synthesis and Friedlander reactions of 5-amino-4-cyano-1,3-oxazoles. The synthesis of 2-substituted 5-amino-4-cyano-1,3-oxazoles (1-4, 6-11) and the Friedländer-type reaction of compounds 1, 3, 4 is described. Compounds 13-17 are tacrine (18) analogues provided by the Friedländer reaction. The anti-cholinesterase activity of compounds 13, 14, 16 and 17 has been investigated.. 2007. Carreiras, Maria do Carmo; Eleutério, Ana; Dias, Catarina; Brito, Maria Alexandra; Brites, Dora; Marco-Contelles, José; Gómez-Sánchez, Elena. http://dx.doi.org/10.3987/COM-07-11110.
    http://dx.doi.org/10.3987/COM-07-11110
  11. Cellular mechanisms underlying dysfunction of immature neurons by hyperbilirubinemia and inflammation. 2007. Vaz, Ana Rita; Silva, Sandra L.; Fernandes, Adelaide; Falcao, Ana Sofia; Silva, Rui F. M.; Brito, M. Alexandra; Brites, Dora. http://hdl.handle.net/10451/21554.
  12. Apoptosis and impairment of neurite network by short exposure of immature rat cortical neurons to unconjugated bilirubin increase with cell differentiation and are additionally enhanced by an inflammatory stimulus. Nerve cell injury induced by unconjugated bilirubin (UCB) has been implicated in brain damage during severe neonatal hyperbilirubinemia, although the molecular mechanisms underlying UCB neurotoxicity are still not clarified. It has been suggested recently. 2007. Falcao, Ana S.; Silva, Rui F. M.; Pancadas, Sergio; Fernandes, Adelaide; Brito, Maria A.; Brites, Dora. http://hdl.handle.net/10451/21566.
    http://dx.doi.org/10.1002/jnr.21227
  13. Profile of early microglial activation by unconjugated bilirubin. 2007. Silva, Sandra L.; Vaz, Ana Rita; Fernandes, Adelaide; Falco, Ana S.; Brito, M. Alexandra; Silva, Rui F. M.; Brites, Dora. http://hdl.handle.net/10451/21553.
  14. Roles of amyloid beta-peptide-associated oxidative stress and proteomics-identified brain protein oxidative modifications in the pathogenesis of Alzheimer's disease. 2007. Brito, Maria Alexandra; Lima, Silvia; Fernandes, Adelaide; Fulcao, Ana Sofia; Silva, Rui F. M.; Butteifield, D. Allan; Brites, Dora. http://hdl.handle.net/10451/21151.
  15. MAPKs are key players in mediating cytokine release and cell death induced by unconjugated bilirubin in cultured rat cortical astrocytes. When activated by unconjugated bilirubin (UCB), astrocytes are important sources of inflammatory mediators such as TNF-alpha, IL-1 beta and IL-6, which may contribute for the neurotoxicity observed during severe neonatal hyperbilirubinemia. In the present. 2007. Fernandes, Adelaide; Falcao, Ana S.; Silva, Rui F. M.; Brito, Maria A.; Brites, Dora. http://hdl.handle.net/10451/21564.
    http://dx.doi.org/10.1111/j.1460-9568.2007.05340.x
  16. Influence of hypoxia and ischemia preconditioning on bilirubin damage to astrocytes. Hypoxia-ischemia in the perinatal period is a common cause of neurologic disability in children and is often associated with neonatal morbidity and mortality. Another frequent condition of the newborn is hyperbilirubinemia and it is well known that deposi. 2007. Falcao, Ana S.; Silva, Rui F. M.; Fernandes, Adelaide; Brito, Maria A.; Brites, Dora. http://hdl.handle.net/10451/21565.
    http://dx.doi.org/10.1016/j.brainres.2007.02.039
  17. Bilirubin induces oxidative stress in neurons, which is prevented by nNOS inhibition. 2007. Brito, Maria A.; Vaz, Ana R.; Lima, Silvia; Fernandes, Adelaide; Falcao, Ana S.; Silva, Sandra L.; Silva, Rui F. M.; Brites, Dora. http://hdl.handle.net/10451/21551.
  18. Unconjugated bilirubin impairs neurite outgrowth in mouse hippocampal neurons. Is there an action at the growth cone?. 2007. Borralho, Adelaide Fernandes; Brites, Dora; Lanier, Lorene M.. http://hdl.handle.net/10451/21579.
  19. Bilirubin toxicity to human erythrocytes: a review. Neonatal jaundice, a physiologic condition reflecting the interplay between developmentally modulated changes in bilirubin production and metabolism, affects virtually all newborn infants. Usually, it is an entirely benign process that is resolved at the. 2006. Brito, Maria Alexandra; Silva, Rui F. M.; Brites, Dora. http://hdl.handle.net/10451/21577.
    http://dx.doi.org/10.1016/j.cca.2006.06.012
  20. Unconjugated bilirubin activates and damages microglia. Microglia are the resident immune cells of the brain and are the principal source of cytokines produced during central nervous system inflammation. We have previously shown that increased levels of unconjugated bilirubin (UCB), which can be detrimental to. 2006. Gordo, Ana C.; Falcao, Ana S.; Fernandes, Adelaide; Brito, Maria A.; Silva, Rui F. M.; Brites, Dora. http://hdl.handle.net/10451/21541.
    http://dx.doi.org/10.1002/jnr.20857
  21. Release of cytochrome C with the interaction of bilirubin, amyloid beta-peptide and glycochenodeoxycholate from isolated mitochondria.. The pathogenesis of cholestasis, bilirubin encephalopathy, and Alzheimer's disease appears to result from accumulation of diverse cytotoxic agents, which in turn may cause apoptotic cell death. In addition, mitochondria has lately been considered as a central executioner of programmed cell death, through the release of caspase activating factors. The aims of this study were to: (a) investigate mit. 2002. Solá, Susana; Diógenes, Maria José; Brites, Dora; Rodrigues, Cecília M P. https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1964.
  22. Bilirubin directly disrupts membrane lipid polarity and fluidity, protein order, and redox status in rat mitochondria. Background/Aims: Unconjugated bilirubin (UCB) impairs crucial aspects of cell function and induces apoptosis in primary cultured neurones. While mechanisms of cytotoxicity begin to unfold, mitochondria appear as potential primary targets. Methods: We used electron paramagnetic resonance spectroscopy analysis of isolated rat mitochondria to test the hypothesis that UCB physically interacts with mit. 2002. Moura, José J. G.; Rodrigues, Cecília M. P.; Solá, Susana; Brito, Maria A.; Brites, Dora. http://hdl.handle.net/10362/1677.
  23. Membrane structural changes support the involvement of mitochondria in the bile salt-induced apoptosis of rat hepatocytes. The accumulation of toxic bile salts within the hepatocyte plays a key role in organ injury during liver disease. Deoxycholate (DC) and glycochenodeoxycholate (GCDC) induce apoptosis in vitro and in vivo, perhaps through direct perturbation of mitochondrial membrane structure and function. In contrast, ursodeoxycholate (UDC) and its taurine-conjugated form (TUDC) appear to be protective. We show h. 2002. Solá, Susana; Brito, Maria A.; Brites, Dora; Moura, José J. G.; Rodrigues, Cecília. http://hdl.handle.net/10362/8715.
  24. Effects of bilirubin molecular species on membrane dynamic properties of human erythrocyte membranes: a spin label electron paramagnetic resonance spectroscopy study. Unconjugated bilirubin is a neurotoxic pigment that interacts with membrane lipids. In this study we used electron paramagnetic resonance and the spin labels 5-, 7-, 12-, and 16-doxyl-stearic acid (DSA) to evaluate the depth of the hydrocarbon chain at which interaction of bilirubin preferentially occurs. In addition, we used different pH values to determine the molecular species involved. Reseale. 2001. Brito, Maria Alexandra; Brondino, Carlos D.; Moura, José J. G.; Brites, Dora. http://hdl.handle.net/10451/28636.
    https://doi.org/10.1006/abbi.2000.2210
  25. Inhibition of glutamate uptake by unconjugated bilirubin in cultured cortical rat astrocytes : role of concentration and pH. The molecular basis of bilirubin toxicity to nerve cell function is still unclear. Since astrocytes are the main transporters of synaptically released glutamate and impaired glutamate uptake results in neuronal death, we investigated the effect of unconjugated bilirubin (UCB) on [3Hlglutamate uptake in cultured rat astrocytes and the role of bilirubin ionization on toxicity. Astrocytes were incuba. 1999. Silva, Rui; Mata, Lucinda R.; Gulbenkian, Sérgio; Brito, Maria A.; Tiribelli, Claudio; Brites, Dora. http://hdl.handle.net/10451/28688.
    https://doi.org/10.1006/bbrc.1999.1646
  26. Relevance of serum bile acid profile in the diagnosis of intrahepatic cholestasis of pregnancy in an high incidence area: Portugal. Objective(s): The present work was conducted to clarify the relevance of usual liver function tests, and define the most predictive serum bile acid profile for diagnosis of intrahepatic cholestasis of pregnancy (ICP). Study design: This study comprised 20 healthy nonpregnant women and 77 pregnant women in the last trimester of pregnancy, from which 38 were normal pregnancies, and 39 suffered from. 1998. Brites, Dora; Rodrigues, Cecília M. P.; van-Zeller, Helena; Brito, Alexandra; Silva, Rui. http://hdl.handle.net/10451/28649.
    http://dx.doi.org/10.1016/S0301-2115(98)00086-4
  27. Correction of maternal serum bile acid profile during ursodeoxycholic acid therapy in cholestasis of pregnancy. Background/Aims: Intrahepatic cholestasis of pregnancy is characterized by pruritus and increased levels of serum bile acids, and is often associated with premature delivery, fetal distress, and perinatal mortality. The aims of the present study were: (i) to better define the serum bile acid profile in intrahepatic cholestasis of pregnancy and its potential usefulness for differential diagnosis; (. 1998. Brites, Dora; Rodrigues, Cecília M. P.; Oliveira, Nuno; Cardoso, Maria da Conceição; Graça, Luís M.. http://hdl.handle.net/10451/28490.
    http://dx.doi.org/10.1016/S0168-8278(98)80207-9
  28. Elevated levels of bile acids in colostrum of patients with cholestasis of pregnancy are decreased following ursodeoxycholic acid therapy. 1998. Brites, Dora; Rodrigues, Cecília M. P.. http://hdl.handle.net/10451/28638.
    http://dx.doi.org/10.1016/S0168-8278(98)80255-9
  29. Unusual case of severe cholestasis of pregnancy with early onset, improved by ursodeoxycholic acid administration. An exceptional case of early onset and prolonged postpartum course of intrahepatic cholestasis of pregnancy is described. Contrary to other drugs tested, ursodeoxycholic acid administered after the 29th week of gestation improved pruritus and decreased bile acid leveis both in serum and amniotic fluid. Labour was induced at 36 weeks, and a female weighing 2.050 g and with an Apgar score of nine wa. 1998. Brites, Dora; Rodrigues, Cecília M. P.; Cardoso, Maria da Conceição; Graça, Luís M.. http://hdl.handle.net/10451/28491.
    http://dx.doi.org/10.1016/S0301-2115(97)00185-1
  30. Beneficial effect of ursodeoxycholic acid on alterations induced by cholestasis of pregnancy in bile acid transport across the human placenta. 1998. Serrano, Maria A.; Brites, Dora; Larena, Monica G.; Monte, Maria J.; Bravo, M. Pilar; Oliveira, Nuno; Marin, José J. G.. http://hdl.handle.net/10451/28637.
  31. Effect of bilirubin on erythrocyte shape and haemolysis, under hypotonic, aggregating or non-aggregating conditions, and correlation with ceil age. 1997. Brites, Dora; Silva, Rui; Brito, Alexandra. http://hdl.handle.net/10451/25753.
    http://dx.doi.org/10.3109/00365519709099407
  32. Determinação da bilirrubina em patologia neonatal: modificação do método de Pays para concentrações de 1 a 10 mg por 100 ml. 1978. Brites, Dora; da Silveira, Carlos; Pays, Michel. http://hdl.handle.net/10451/28656.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2024 Tailored Exosomal miRNA-124-3p Delivery: A Targeted Therapeutic Approach for Alzheimer's Disease AD/PD™ 2024: Striving for a better future for all those affected by neurodegenerative diseases
Feira das Indústrias (Paquistão)
2023/10/12 Exosomal microrna-124-3p delivery as a therapeutic strategy in Alzheimer’s disease Annual Meeting of the European Tissue Repair Society (ETRS) & Portuguese Society of Stem Cells and Cell Therapies (SPCE-TC) 2023
Auditório da Reitoria da Universidade de Coimbra
2023/09 MIR-124 BASED THERAPIES FOR NEURODEGENERATIVE DISORDERS 11th IBRO World Congress of Neuroscience IBRO 2023 – Granada
(Espanha)
2023/06/22 miR-124-3p-loading in neuronal exosomes as a delivery therapeutic system in Alzheimer's disease 2nd Meeting of the Portuguese Network on Extracellular Vesicles
NOVA Medical School, Universidade NOVA de Lisboa
2023/06/16 Promise of miR-124-3p-loaded neuronal exosomes for clinical application in Alzheimer's disease patient subtypes Workshop on novel diagnostic tools for Alzheimer’s disease
University of Aveiro
2023/04/21 Studying neuroimmune-associated miRNA (dys)regulation using Alzheimer´s disease cell models Casual Friday Seminars
NOVA Medical School, Universidade NOVA de Lisboa
2023/02/10 Analyzing Neuroimmune-associated miRNA dysregulation in Alzheimer´s disease 2nd Symposium on Alzheimer's Disease: An Update on Pathology and Therapeutics
Faculty of Engineering of the University of Porto
2023/01/18 Inflammation-associated neurotoxicity in bilirubin pathophysiology Don Ostrow Tieste Yellow Retreat 2023
Trieste University (Itália)
2022/09 Therapeutic potential of small extracellular vesicle-mediated miRNAs in AD BIOMAD Workshop
Università degli Studi di Bari, Bari (Bari, Itália)
2022/01/14 Overview of Molecular, Clinical and Societal Perspectives of Neurodegenerative Disorders Doenças Neurodegenerativas
Rede Saúde - Universidade de Lisboa (Lisbon, Portugal)
2021/12/03 Models and strategies to identify targets and restore cellular homeostasis in ALS Seminar
Universidade de Coimbra (Coimbra)
2021/11/09 Desenvolvimento do Cérebro e Doenças relacionadas ao envelhecimento Liga Acadêmica de Neurociências da UFRJ
Universidade Federal do Rio de Janeiro - Macaé (Rio de Janeiro, Brasil)
2021/06/24 Neuron-glia communication: A holistic paradigm in CNS inflammation and regeneration. IX Simpósio de Neurociências da UFF Symposium/IV Neurosciências da UFF-Fiocruz Symposium
UFF-Fiocruz (Rio de Janeiro, Brasil)
2021/06/21 Regulation and dysregulation of neuron-glia signaling by miRNAs in ALS Conference in the Meeting “Diseño y Desarrollo de Fármacos Innovadores para el Tratamiento de la Esclerosis Lateral Amiotrófica”
ALS day - Reunión Programa ELA-Madrid, BMD2017/3813 (Madrid, Espanha)
2021/06/18 Neuroinflammation in Neurodegenerative Diseases: Glial cell phenotypes and microRNAs. SAN Virtual Monthly Lecture Series
Argentinian Society for Research in Neuroscience (Argentina)
2021/06/10 miR-146a reverts the phenotypic aberrancies of cortical astrocytes and prevents paracrine pathogenicity in ALS Extracellular Vesicles (Virtual Meeting)
European Society of Clinical Investigation
2021/02/26 Neuro-immune interactions: A holistic paradigm in CNS pathology and regeneration Seminar at Promoting Health by addressing the disease
iMed.ULisboa, Faculty of Pharmacy, University of Lisbon (Lisbon, Portugal)
2021/02/26 Neuro-immune interactions: A holistic paradigm in CNS pathology and regeneration Seminar at Promoting Health by addressing the disease
iMed.ULisboa, Faculty of Pharmacy, Universidade de Lisboa (Lisbon, Portugal)
2020/12/18 Extracellular vesicle-miRNAs in Neuroinflammation. First Workshop of the Portuguese Network on Extracellular Vesicles: EVs in Health and Disease
I3S, University of Porto (Porto, Portugal)
2020/09/05 MicroRNAs in neuroinflammation: implications for neurodegenerative diseases Reunião Anual do Programa de Pós-graduação em Imunologia
Universidade Federal da Bahia (São Salvador, Brasil)
2019/11/10 Distúrbios neurocognitivos associados à infeção por HIV. Fisiopatologia do SNC II Curso Pós-graduado de Atualização em Virologia: Coinfeções e comorbilidades assocoadas à infeção por HIV.
Faculdade de Farmácia da Universidade de Lisboa (Lisboa, Portugal)
2019/11/09 Amyotrophic Lateral Sclerosis: Research at iMed.Ulisboa Minho Medical Meeting
Universidade do Minho (Braga, Portugal)
2019 Immunointervention as therapeutics in neurodegenerative diseases V Simpósio Internacional de Neuroquímica e Fisiopatologia da Célula Glia
Universidade Federal da Bahia (São Salvador, Brasil)
2019 Bilirubin-induced neural impairment. XXVI Perinatal Medicine XXXVI Perinatal Medicine
(St Petersburg , Rússia)
2019 Dysregulated glial phenotypes and neuro-immune communication in neurodegenerative diseases XVI Meeting of the Portuguese Society for Neuroscience
Portuguese Society for Neuroscience (Lisbon, Portugal)
2019 Deciphering neuron-microglia interactions in disease progression XIV European Meeting on Glial Cells in Health and Disease
(Porto, Portugal)
2019 Microglia, neuroinflammation and neurodegeneration. Introductory Course XIV European Meeting on Glial Cells in Health and Disease
(Porto, Portugal)
2019 Glial Cells in Neurodegenerative Diseases Programa de Pós-graduação em Imunologia
Universidade Federal da Bahia (São Salvador, Brasil)
2018 Deciphering neuron-glia interactions and therapeutic opportunities in neurodegenerative diseases XIX Congress of the Brazilian Society for Cell Biology
Brazilian Society for Cell Biology (São Paulo, Brasil)
2018 Implication of neuron-glia deregulated communication in brain degenerative diseases. Evidence and unanswered questions SynaNET H2020 Satellite Symposium
Instituto de Medicina Molecular (Lisbon, Portugal)
2018 Exosomes derived from SH-APPSwe cells show increased levels of miR-124, miR-21 and miR-125b and determine microglia autophagic dysfunction 1st Meeting on Vesicular Biology
University of Coimbra (Coimbra, Portugal)
2018 Glia phenotypic changes and regional differences in amyotrophic lateral sclerosis. Plenary Talk. III Symposium of the Portuguese Glial Network
University of Porto (Porto, Portugal)
2018 Deregulation and reshape of inflammatory responses by cellular and exosomal microRNAs in neurodegenerative diseases Secretome WithOut Borders
Minho University (Braga, Portugal)
2017 iPSCs-derived astrocytes from patients with PSEN1¿E9 mutation show a depressed RAGE/miR-155 pathway with impact in extracellular vesicle molecular cargo 10th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies
Portuguese Society for Stem Cells and Cell Therapies (Covilhã, Portugal)
2017 Exosomes from motor neurons overexpressing human SOD!G93A gene induce microglia activation and dysfunction 2017 PCS International Conference of Neuroscience (ICN-2017)
(Lisbon, Portugal)
2017 Microglia phenotypic heterogeneity and vesicular trafficking in ALS disease Portuguese Glial Network . II Symposium Glial cells: much more than glue
Minho University (Braga, Portugal)
2016 Visiting Neuroinflammationin in Neurodevelopmental and Neurodegenerative Diseases Symposium on Chronological change in Brain function . Brain Diseases, Brain Aging, and Memory Research at the forefront
Chiba University (Chiba, Japão)
2016 Neuroinflammation in depression: microglia activation and dysfunction 9th International Symposium on Neuropsychiatry & HIV
(Barcelona, Espanha)
2016 Heterogeneity of astrocytes and microglia in neurodegenerative diseases” 45ª Annual Meeting of Brazilian Society for Biochemistry and Molecular Biology
Brazilian Society for Biochemistry and Molecular Biology (Natal, Brasil)
2016 Dysregulation of neuron-glia axis in neuroinflammation EIT-Health Ageing Brain - Summer School
Groningen University (Groningen)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2023/10 - Atual miRNA Engineering of Neural-derived Exosomes as a Promising Therapeutic Strategy for Alzheimer¿s Disease - Mafalda Miguéis
Orientador de Mafalda Maria Migueis Bragança
 PhD - Biologia Molecular e Celular (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/09/01 - Atual Therapeutic Potential of miRNA-loaded Exosomes in Alzheimer’s Disease - Sofia Guerra
Orientador de Sofia Alexandra Vieira Guerra
 Ciências Biofarmacêuticas (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/09 - Atual Testing miRNA-engineered exosomes as regulators of inflammation in Alzheimer's disease research models - Maria Queirós
Orientador
 Bioquímica e Biomedicina (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2022 - Atual PhD thesis - Cell-free-based therapies for miRNA modulation in ALS-associated TDP-43 proteinopathy using mouse and human models - Ana Teresa Matos
Coorientador
 Medical and Health Sciences (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2022 - Atual PhD thesis - BDNF receptor cleavage: insight on neuronal TrkB-ICD extracellular vesicle trafficking and proteolysis in Alzheimer's disease - FCT 2022.10594.BD
Coorientador
 Biomedical Sciences - Neurosciences (Doutoramento)
Universidade de Lisboa Faculdade de Medicina, Portugal
2018 - Atual PhD thesis - Deciphering the role of extracelular membrane vesicles in dissemination of HIV, CNS colonization and pathogenesis of HIV-associated neurological disorders - (SFRH/BD/131948/2017)
Coorientador
 Microbiologia (Doutoramento)
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2023/09/01 - 2024/03/31 Post Doc - ANIMATE PROJECT FCT PDTC/MED-NEU/2382/2021 - Gonçalo Garcia
Orientador de Gonçalo Garcia
 Neurosciences (Outra)
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2022/09/01 - 2024/01/20 Comparative Efficacy of CK1 Inhibitors and miRNA-loaded Exosomes on the Recovery of ALS Injured Microglia
Coorientador
 Mestrado em Ciências Biofarmacêuticas (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2022/09/01 - 2024/01 Master thesis - Novel therapeutic strategies based on microRNA modulation in diseased cells or direct transfection into extracellular vesicles from neural precursor cells - Artemizia Évora
Orientador
 Biochemistry and Biomedicine (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2022/12/26 - 2023/12/22 Post Doc Training - Loading and therapeutic efficacy of Exo-miRNAs using human and mouse models of Alzheimer's disease. Miriam Corraliza
Orientador
 Neurosciences - Grant Margarida Salas (Outra)
Universidad de Cádiz, Espanha
2023/02/01 - 2023/10/31 Master Thesis -Testing the therapeutic application of exosome-mediated microRNAs to regenerate neuron-glia homeostasis in Alzheimer¿s Disease using cocultures/tricultures and microfluidic devices - Marta Ianni
Orientador
 Corso di Laurea Magistrale in Neuroscienze (Mestrado)
Università degli Studi di Trieste, Itália
2022 - 2023 Master thesis - Comparative efficacy of CK1 inhibitors and miRNA-loaded exosomes on the recovery of ALS injured microglia - Rita Barbosa
Coorientador
 Biopharmaceutical Sciences (Mestrado)
Faculdade de Farmácia da Universidade de Lisboa, Portugal
2011 - 2023 Postdoctoral supervision - Dissecting the mechanims of microglia response, determinants and biomarkers in amyotrophic lateral sclerosis (FCT SFRH/BPD/76590/2011)
Orientador
 Post-doc
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019 - 2022/07 PhD Thesis - Assessment of phenotypic modulation of ALS­-ASTRO-­TOX cells and their secretome toward motor neuron survival using new advanced experimental models - FCT - SFRH/BD/129586/2017 - Marta Barbosa
Orientador
 PhD (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/11/01 - 2022/04/30 PhD Thesis - Role of neural exosomes on microglia activation/dysfunction using AD cell line models and AD iPSCs-derived neurons and astrocytes in 2D/3D culture systems - Gonçalo Garcia
Orientador
 PhD (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021 - 2022 Master Thesis - Evaluation of neuron/glia network signals using 2D/3D platforms and ALS experimental models - Beatriz Suyumov B
Orientador
 Biopharmaceutical Sciences (Mestrado)
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2021 - 2022 Master Thesis - Testing efficiency of modified exosomes on 3D and mouse models. Nísia Martins
Orientador
 Molecular Genetics and Biomedicine (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2021 - 2022 Master Thesis - Modulation of miRNA Expression in ALS Microglia - Teresa Matos
Orientador
 Master in Biochemistry (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2021 - 2022 Master thesis - Neuronal miR-124 in Alzheimer’s Disease human models: from cell functioning to trafficking - Henrique Mamede
Orientador
 Biological Engineering (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2021 - 2022 Master Thesis - Unveiling paracrine dissemination and toxicity of neuronal TrkB-ICD via secretome signalling in Alzheimer’s disease - Tiago Coelho
Orientador
 Biochemistry for Health (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2021 - 2022 Master thesis - Therapeutic Potential of Intrathecal Application of miR-124-based Secretome in the SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis - Marta Santos
Orientador
 Molecular Genetics and Biomedicine (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019 - 2022 Master Thesis - Unveiling aberrancies and neurotoxic properties of ALS astrocytes using unspecific and microglia-specific activation models. Isabel Maurício
Orientador
 Biopharmaceutical Sciences (Mestrado)
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2017 - 2022 PhD thesis - Targeting Neuroinflammation: From target validation to rational design of selective modulators (PhD student from FCT/MedChemTrain – PD/BD/135292/2017)
Coorientador
Universidade de Coimbra Faculdade de Farmácia, Portugal
2017 - 2022 PhD thesis - Deciphering the role of extracellular membrane vesicles in dissemination of HIV, CNS colonization and pathogenesis of HIV-associated neurologic disorders (PhD student from FCT – SFRH/BD/131948/2017)
Coorientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/03 - 2021/07 Post-doc - New Psychoactive Substances - A Platform for Risk Assessment of Teens Brain
Coorientador
 Postdoc (Outra)
Faculdade de Farmácia da Universidade de Lisboa, Portugal
2019/09 - 2021/05 Master Thesis - Role of astrocyte activation on microglia polarization polarization polarization in Amyotrophic Lateral Sclerosis Sclerosis (ALS)
Orientador de Laura Prezado
 mestrado em Ciências Biomédicas no IHMT (Mestrado)
Universidade Nova de Lisboa, Portugal
2019/03/01 - 2021/02/28 Postdoctoral Project “Development of an autologous exosome-based therapy by engineering microRNAs in microglia and motor-neurons using mice and human models of amyotrophic lateral sclerosis (ALS)” (ExomiRALS) (PTDC/MED-NEU/31395/2017)”.
Orientador
 Postdoctoral Researcher (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/09 - 2021/01 Master thesis - Impact of emergent new psychoactive substances (NPS) on neuronal and microglial function
Orientador
 Grau de Mestre em Genética Molecular e Biomedicina (Mestrado)
Universidade Nova de Lisboa, Portugal
2020 - 2021 Master thesis - The aberrant iNPCs-derived human astrocytes in early-stage ALS
Orientador
 Master in Biopharmaceutical Sciences (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019 - 2021 Master thesis - Using iPSCs-derived microglia from Alzheimer´s disease patients to assess early cell deficits and neurotoxic properties
Orientador
 Mestrado em Bioquímica - Bioquímica Médica (Mestrado)
FACULDADE DE CIÊNCIAS, UNIVERSIDADE DE LISBOA, Portugal
2019 - 2021 Master thesis - Development of secretome-based therapy by motor neuron modulation of miRNA-124 in ALS mouse model - Hermes Morais
Orientador
 Molecular Genetics and Biomedicine (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019 - 2021 Master Thesis - Role of astrocyte activation on microglia polarization in amyotrophic lateral sclerosis (ALS) - Laura Prezado
Orientador
 Biomedical Sciences (Mestrado)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2020/02 - 2020/11 Master degree - Neuronal miR-124 in Alzheimer's Disease human models: from cell functioning to trafficking
Orientador de Henrique Paulino Sasso Pereira Mamede
 Thesis to obtain the Master of Science Degree in Biological Engineering (Mestrado)
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
2020 - 2020 Master degree - Secretome from Early AD organoids Activates the inflammatory state of non-activated and activated microglia
Orientador
 Master of Science Degree in Biological Engineering (Mestrado)
2019 - 2020 Master Thesis - Dissecting neuronal miRNA-124 modulation: effects on secretome-mediated microglial deregulation in mSOD1-associated Amyotrophic Lateral Sclerosis
Orientador
 Master in Neurosciences (Mestrado)
Universidade de Lisboa Faculdade de Medicina, Portugal
2019 - 2019 Master thesis - Secretome from Early AD organoids Activates the inflammatory state of non-activated and activated microglia
Orientador
 Biological Engineering (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2018 - 2019 Master Thesis - Differences in AD astrocyte phenotypes and responses to microglial derived cytokines
Orientador
 Molecular Genetics and Biomedicine (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018 - 2019 Master Thesis - Dissecting the interplay between activated astrocytes and neurons in an in vitro model of Alzheimers' disease.
Orientador
 Biopharmaceutical Sciences (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018 - 2019 Master Thesis. Unveilling the interplay between activated astrocytes and neurons in an in vitro model of Alzheimer’s disease
Orientador
 master Course in Biopharmaceutical Sciences (Mestrado)
2016 - 2019 PhD thesis - Novel Therapeutic Approach to Amyotrophic Lateral Sclerosis: Targeting Neurotoxic Astrocytes before transplantation (PhD student from FCT – SFRH/BD/102718/2014)
Orientador de Cátia Sofia Vicente Gomes
 Farmácia (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - 2019 PhD thesis - Novel therapeutic approach to ALS: targeting aberrant-like astrocytes before transplantation (PhD student from FCT – SFRH/BD/102718/2014)
Orientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2018 Master Thesis - Exploring A1 activation and miR-155 modulation in ALS spinal cord astrocytes
Orientador
 Genética Molecular e Biomedicina
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017 - 2018 Master thesis - Targeting miR-124 in motor neurons as a therapeutic strategy to prevent neurodegeneration and glial activation in ALS
Orientador
 Master Course in Biopharmaceutical Sciences (Mestrado)
2017 - 2017 Master thesis - Balance between pro-inflammatory/anti-inflammatory indicators of SOD1G93A microglia in steady conditions and modification by immunomodulation
Orientador de Catarina Alexandra Barbosa Ezequiel
 Ciências Biofarmacêuticas (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 - 2017 Master thesis - Dissecting deregulated cell-to-cell communication in in vitro Alzheimer’s disease models
Orientador
Faculdade de Ciências e Biotecnologia da Universidade Nova de Lisboa, Portugal
2016 - 2017 Master thesis - Evaluation and regulation of neuroinflammation via microglia-derived extracellular vesicles and associated DAMPs/miRNAs
Orientador
 Biologia Molecular Humana (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 - 2017 PhD thesis - Role of glial cells as contributors to the onset and propagation of ALS disease
Orientador
 Farmácia (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2013 - 2017 PhD thesis - S100B in central nervous system demyelination and remyelination: looking at cytoskeleton (PhD student from FCT – SFRH/BD/91437/2012)
Coorientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2011 - 2017 Postdoctoral Supervision - Role of glia in neuronal development and plasticity (FCT – Ciência 2007 - C2007-FFUL/UBMBE/02/2011)
Orientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 - 2016 Master thesis - ALS pathogenesis: role of motor neuron-derived exosomes in microglia activation and dysfunction
Orientador
 Ciências Biofarmacêuticas (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - 2016 Master thesis - Exploring changes in functional properties of reactive and aged microglia bBy unconjugated bilirubin
Orientador
Università degli Studi di Bologna Dipartimento di Farmacia e Biotecnologie, Itália
2013 - 2013 PhD thesis - Evaluation of neuroprotective and neurotoxic functions of different microglia phenotypes in Alzheimer’s disease onset and progression, using in-vitro and in-vivo models
Orientador
 Farmácia (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2013 - 2013 Master thesis - Profiling new histological biomarkers for oligodendrogliomas
Coorientador
 Ciências Biofarmacêuticas (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2012 - 2012 PhD thesis - A Bilirrubina Altera a Mielinização no Período Neonatal Precoce (PhD student from FCT – SFRH/BD/43885/2008)
Orientador
 Farmácia (Doutoramento)
2008 - 2012 PhD thesis - Molecular Mechanisms of Microglia Reactivity to Bilirubin: Evaluation of Potential Neurological Effects (PhD student from FCT – SFRH/BD/30326/2006)
Orientador
 Farmácia (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2010 - 2011 Postdoctoral supervision - The potential of nanoparticle-based delivery of ursodeoxycholic acid to the brain: overcoming the blood-brain barrier (Post-doc from FCT SFRH/BPD/63785/2009)
Coorientador
2009 - 2011 Postdoctoral supervision - Role of glia in neuronal development and plasticity (FCT – Ciência 2008 - C2008-FFUL/UBMBE/02/2008)
Orientador
2008 - 2009 Postdoctoral Supervision - Discovery of new drugs as modulators of neurotoxicity in both neurodevelopmental and neurodegenerative diseases (FCT – Ciência 2007 - C2007-FFUL/UBMBE/02/2007)
Orientador
2008 - 2008 PhD thesis - Identification of Cellular Targets for Specific Therapies in Neurodevelopmental Disorders (PhD student from FCT – SFRH/BD/30292/2006)
Orientador
 Farmácia (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2004 - 2007 Postdoctoral supervision - Estudo das diferentes manifestações citopatológicas causadas pela hiperbilirrubinémia e colestase e sua modulação farmacológica (Post-doc from FCT FFRH/BPD/6525/2001)
Orientador
2002 - 2006 PhD thesis - New Findings on Neuropathological Effects of Hyperbilirubinemia in Astrocytes and Neurons - Evaluation of Cell Susceptibilities and of Neuritic Development (PhD student from FCT – SFRH/BD/8436/2002)
Orientador
 Farmácia (Doutoramento)
1995 - 2001 PhD thesis - Interacção da Bilirrubina com o Eritrócito: Espécies Moleculares Envolvidas, Estádios de Toxicidade e Comportamento da Célula Fetal
Orientador
 Farmácia (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
1995 - 2001 PhD thesis - Estudo das Vias Neurobiológicas de Lesão Cerebral Durante a Hiperbilirrubinémia Neonatal: Comportamento e Vulnerabilidade Celulares
Orientador
 Farmácia (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
1996 - 2000 Postdoctoral supervision - Apoptosis in the pathogenesis and treatment of liver disease. Molecular and biological effects of ursodeoxycholic acid
Orientador

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2023/11/07 - 2023/11/07 2nd Workshop on Biochemistry of Ageing (2023/11/07 - 2023/11/07)
Conferência (Presidente da Comissão Organizadora)
2023/05/02 - 2023/05/02 VII Symposium of the Portuguese Glial Network Member of the Scientific Committee (2023/05/02 - 2023/05/02)
Conferência (Membro da Comissão Científica)
 Rede Glial Poruguesa, Portugal
2022 - 2022 Chair of the Symposium “Molecular Medicine II – Neurodegeneration (2022 - 2022)
Congresso (Membro da Comissão Científica)
 International Union of Biochemistry and Molecular Biology, Países Baixos
2021 - 2021 Member of the Scientific Committee (2021 - 2021)
Congresso (Membro da Comissão Científica)
 Sociedade Portuguesa de Neurociências, Portugal
2021 - 2021 Membro da Comissão Científica (2021 - 2021)
Conferência (Membro da Comissão Científica)
 Rede Glial Poruguesa, Portugal

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2022 - Atual AIMS Meeting Research Competition - Neurosciences field
Avaliador
2023 - 2023 Assessment of a research proposal submitted to the Medical Research Council, UK
Avaliador
 UK Research and Innovation, Reino Unido Medical Research Council
2021 - 2021 Research Projects Program Ideas, Serbia
Avaliador
 Fond za nauku Republike Srbije, Sérvia Fond za nauku Republike Srbije
2020 - 2020 junior research professorships (BOFZAP) - Louvain
Avaliador
 UCL, Bélgica UCL
2019 - 2019 WELBIO - CONTINUATION GRANT [CGR] - FRFS/FNRS
Avaliador
 Checa Czech Science Foundation, República Checa Checa Czech Science Foundation
2019 - 2019 Biomedicine Panel - FCT
Avaliador
 Fundação para a Ciência e a Tecnologia, Portugal Fundação para a Ciência e a Tecnologia
2018 - 2019 Projects FCT-CAPES
Avaliador
 Fundação para a Ciência e a Tecnologia, Portugal Fundação para a Ciência e a Tecnologia
2018 - 2019 Project Evaluation - Life Sciences - Poland and grants for doctoral students Program PRELUDIUM 15
Avaliador
 Narodowe Centrum Nauki, Polónia Narodowe Centrum Nauki
2017 - 2019 Research Projects on Neurological Disorders and Stem Cell Biology -FNRS
Avaliador
 National Fund for Scientific Research (NFSR) (Dutch: Nationaal Fonds voor Wetenschappelijk Onderzoek (NFWO), French: Fonds National de la Recherche Scientifique (FNRS), Bélgica National Fund for Scientific Research
2018 - 2018 Research project - BBSRC
Avaliador
 Biotechnology and Biological Sciences Research Council, Reino Unido Biotechnology and Biological Sciences Research Council
2018 - 2018 Research Project - Ministero della Salute, Pavia, Italy Fondazione per la Ricerca Biomedica Avanzata, Itália Fondazione per la Ricerca Biomedica Avanzata
2018 - 2018 Research Project - ARSLA, French
Avaliador
 Association pour la Recherche sur la Sclérose Latérale Amyotrophique et autres Maladies du Motoneurone, França Association pour la Recherche sur la Sclérose Latérale Amyotrophique et autres Maladies du Motoneurone
2015 - 2015 Research proect evaluation - MRC - UK
Avaliador
 Medical Research Council, Reino Unido Medical Research Council
2015 - 2015 Proposal evaluation - COST
Avaliador
 European Cooperation in Science and Technology, Bélgica European Cooperation in Science and Technology
2015 - 2015 Research Project Evaluation - Prinses Beatrix Spierfonds
Avaliador
 Prinses Beatrix Spierfonds, Países Baixos Prinses Beatrix Spierfonds
2014 - 2014 Research Project Evaluation - Action on Hearing Loss – International Project Grant, Plymouth
Avaliador
 Action on Hearing Loss, Reino Unido Action on Hearing Loss
2013 - 2013 PhD and Post-doc fellowships - Imunologia e Infeção & Neurociências, Envelhecimento e Doenças Degenerativas
Avaliador
 Fundação para a Ciência e a Tecnologia, Portugal Fundação para a Ciência e a Tecnologia
2011 - 2011 Research Project evaluation - RNID - London
Avaliador
 Action on Hearing Loss, Reino Unido Action on Hearing Loss
2010 - 2010 Polish-German Scientific Copernicus Award - DFG and FNP
Avaliador
 Deutsche Forschungsgemeinschaft, Alemanha Fundacja na rzecz Nauki Polskiej
2007 - 2009 Research project evaluation - Arlington/USA
Avaliador
 National Science Foundation Directorate for Biological Sciences, Estados Unidos National Science Foundation Directorate for Biological Sciences
2006 - 2006 Opinion on intrahepatic cholestasis of pregnancy.
Avaliador
 Clinica Puerta de Hierro, Espanha Clinica Puerta de Hierro

Consultoria / Parecer

Descrição da atividade Instituição / Organização
2020/03/14 - 2021/03/15 BOLSA DE ESTÁGIO SÊNIOR NO ÂMBITO DO PROGRAMA 7786-PROGRAMA NACIONAL DE COOPERAÇÃO ACADÊMICA NA AMAZÔNIA-DRI - PROCESSO CAPES No 88881.370785/2019-01 Prof. Cristovam Wanderley Picanço Diniz PESQUISADOR COLABORADOR NA INSTITUIÇÃO ESTRANGEIRA: Profa. Dora Brites Faculdade de Farmácia da Universidade de Lisboa, Portugal

Tutoria

Tópico Nome do aluno
2023/03/01 - 2023/05/31 Potential benefits of protein kinase inhibitors in recovering microglia funcrion using the SOD1G93A mouse model of amyotrophic lateral sclerosis- Francesca Alberti Francesca Alberti
2023/01/08 - 2023/04/07 Dissecting the role of exosome-miRNAs in AD pathology using advanced human neuron-microglia models - Ceren Gönül Ceren Perihan Gönül
2022/05/03 - 2022/10/22 Modeling neuron-astrocyte interplay in Alzheimer's Disease (AD) and Exo-miRNA testing as a therapeutic strategy Ana María Rubí Callejón
Distinções

Prémio

2015 Best Project in ALS - SCML
Santa Casa da Misericórdia de Lisboa, Portugal

Título

2023 Integrates the book Women in Science edition 2023 - Ciência Viva
2022 Emeritus - Universidade de Lisboa
Universidade de Lisboa, Portugal

Outra distinção

2022 Medal of Honor - Ordem dos Farmacêuticos
Ordem dos Farmaceuticos, Portugal
2019 Member of the Local Organizing Committee, Speaker at the Introductry Course and Organizer of the Symposium 07 on "Role of microglia in Neurogeneration" (Chair and Speaker) at the XIV European Meeting on Glial Cells in Health and Disease, 2019
2017 Translational Research Project - GILEAD
Gilead Sciences Lda, Portugal
2016 Best Research project in Amyotrofic Lateral Sclerosis - Santa Casa
Santa Casa da Misericórdia de Lisboa, Portugal
2015 Research in Morphological Sciences Prize 2016 SAP/AAP
Sociedade Anatómica Portuguesa, Portugal
2014 Best Poster
2012 Bolsa Edgar Cruz e Silva
2012 Best presentation
2012 Best Poster
2009 Best Clinical Case
2009 Best Clinical Case
2004 Best Poster
2002 Research Incentive
Fundação Calouste Gulbenkian, Portugal
2001 Research Award
Ministério da Saúde, Moçambique
2001 Best Work
2000 Best Presentation
2000 Best Poster
2000 Selected Work
1999 Best Poster
1996 Scientific Merit
Hospital Dona Estefânia, Portugal