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Identificação

Identificação pessoal

Nome completo
Miranda Mele

Nomes de citação

  • Mele, Miranda

Identificadores de autor

Ciência ID
A21D-50DC-D78A
ORCID iD
0000-0002-8627-4883

Endereços de correio eletrónico

  • miranda.mele@cnc.uc.pt (Profissional)

Websites

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas
  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Italiano (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Português Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C1) Utilizador proficiente (C2)
Formação
Grau Classificação
2013/12/30
Concluído
 PhD in Biosciences (specialization in Neurosciences) (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Modulation of GABAA receptors in cerebral ischemia: alterations in receptor trafficking coupled to neuronal death after oxygen/glucose deprivation" (TESE/DISSERTAÇÃO)
 Approved with praise and distinction by unanimity
2009
Concluído
 Master Degree in Biology (Laurea Specialistica)
Università degli Studi del Sannio, Itália
"Effect of BDNF on the Ubiquitin-Proteasome System in Cultured Hippocampal Neurons." (TESE/DISSERTAÇÃO)
 110 /110 e lode (Italian)
2007
Concluído
 Degree in Biological Sciences (Laurea)
Università degli Studi del Sannio, Itália
"Rapid individualization of fetal aneuploidies by QF -PCR. Clinical validation of a new diagnostic test" (TESE/DISSERTAÇÃO)
 104 /110 (Italian)
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2021/07/01 - Atual Investigador Auxiliar (carreira) (Investigação) Universidade de Coimbra, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2017/03/01 - 2021/06/30 Pós-doutorado (Investigação) Instituto de Medicina Molecular, Portugal
2015/06/01 - 2018/08/01 Pós-doutorado (Investigação) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2016/10/01 - 2017/10/28 Pós-doutorado (Investigação) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2015/10/15 - 2016/01/15 Pós-doutorado (Investigação) Istituto Italiano di Tecnologia, Itália
2014/07/01 - 2015/05/01 Pós-doutorado (Investigação) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013/10/01 - 2014/06/01 Pós-doutorado (Investigação) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2008/10/01 - 2013/09/30 Investigador (Investigação) Universidade de Coimbra, Portugal
2008/03/15 - 2008/09/15 Estagiário de Investigação (Investigação) Universidade de Coimbra, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2020/06/01 - 2021/03/31 Management and supervision of teams for the diagnosis and monitoring of COVID-19 Universidade de Coimbra, Portugal
Laboratório de Análises Clínicas da Universidade de Coimbra , Portugal
2020/03 - 2020/07 Voluntary in the research and study in the mitigation of COVID 19 Laboratório de Análises Clínicas da Universidade de Coimbra , Portugal
Universidade de Coimbra, Portugal
2006/01/01 - 2006/03/31 Undergraduate student, Scientific training at the Working in the project Prenatal screening for Down syndrome and neural tube defects (NTD), caryotype analysis, DNA analysis, Trombotest, PCR techniqu Azienda Ospedaliera Gaetano Rummo, Itália
Projetos

Bolsa

Designação Financiadores
2018/06/01 - 2021/06/30 BDNF-induced alterations in the synaptic proteome and neuronal excitability in the pilocarpine model of temporal lobel epilepsy
POCI-01-0145-FEDER-028656 PTDC
Investigador responsável
CNC.IBILI, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2018/05/01 - 2021/05/31 Targeting the K+-Cl- cotransporter (KCC2) to maintain GABAergic neurotransmission: a novel therapeutic strategy for epilepsy’.
CENTRO-01-0145-FEDER-030659
Investigador responsável
CNC.IBILI, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2019/04/01 - 2021/03/31 Dynamic modulation of synaptic GABAAR receptors promoted by autoantibodies from epileptic patients
Bolsa Científica da LPCE 2019
Investigador responsável
CNC.IBILI, Portugal
 Liga Portuguesa Contra a Epilepsia
Concluído
2016 - 2017 Novel cerebrospinal fluid and serum biomarkers for Multiple Sclerosis
RG-1601-07502
Investigador Pós-doutorado
CNC.IBILI, Portugal
 National Multiple Sclerosis Society
Concluído
2014/03/01 - 2016/02/29 Alteration in GABAA Receptor trafficking in status epilepticus
Bolsa Científica da LPCE 2014
Investigador responsável
CNC.IBILI, Portugal
 Liga Portuguesa Contra a Epilepsia
Concluído
2013/07 - 2015/09 Downregulation of the GABAergic synaptic transmission in brain ischemia - molecular mechanisms of GABAA receptor internalization
grant.Provided by PTCRIS: 124339
Investigador
Fundação para a Ciência e a Tecnologia
Concluído
2015 - 2015 Regulation of the ubiquitin-proteasome system by BDNF at the hippocampal synapses: role in synaptic plasticity
PTDC/SAU-NMC/120144/2010
Bolseiro de Pós-Doutoramento
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2015 - 2015 New strategies to manage brain disease
CENTRO-07-ST24-FEDER-002002-MAIS CENTRO
Bolseiro de Pós-Doutoramento
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído

Projeto

Designação Financiadores
2013 - Atual Projecto Estratégico CNC.IBILI. CNC.IBILI Institute
UID/NEU/04539/2013
Investigador
CNC.IBILI, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2013 - Atual Projecto Estratégico CNC.IBILI. CNC.IBILI Institute
UID/NEU/04539/2013
 Fundação para a Ciência e a Tecnologia
2021/01/01 - 2025/12/31 Instituto de Medicina Molecular João Lobo Antunes
LA/P/0082/2020
10.54499/LA/P/0082/2020
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2021/01/01 - 2025/12/31 Centro de Inovação em Biomedicina e Biotecnologia - Laboratório Associado
LA/P/0058/2020
10.54499/LA/P/0058/2020
Universidade de Coimbra, Portugal

Universidade Nova de Lisboa ¿Laboratório de Instrumentação Engenharia Biomédica e Física da Radiação, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2022/09/01 - 2024/03/31 Center for Innovative Biomedicine and Biotechnology - Associate Laboratory
LA/P/0058/2020
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2019/01/01 - 2019/12/31 CNC. IBILI
UID/NEU/04539/2019
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal

Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2019/01/01 - 2019/12/31 Instituto de Medicina Molecular - IMM
UID/BIM/50005/2019
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em revista
  1. Belperio, Giorgio; Corso, Claudia; Duarte, Carlos B.; Mele, Miranda. "Molecular Mechanisms of Epilepsy: The Role of the Chloride Transporter KCC2". Journal of Molecular Neuroscience 72 7 (2022): 1500-1515. http://dx.doi.org/10.1007/s12031-022-02041-7.
    10.1007/s12031-022-02041-7
  2. Mele, Miranda; De Luca, Pasqualino; Santos, Ana Rita; Vieira, Marta; Salazar, Ivan L.; Pinheiro, Paulo S.; Duarte, Carlos B.. "GRASP1 ubiquitination regulates AMPA receptor surface expression and synaptic activity in cultured hippocampal neurons". The FASEB Journal 35 8 (2021): http://dx.doi.org/10.1096/fj.201903061rr.
    10.1096/fj.201903061rr
  3. Mele, Miranda; Vieira, Ricardo; Correia, Bárbara; De Luca, Pasqualino; Duarte, Filipe V.; Pinheiro, Paulo S.; Duarte, Carlos B.. "Transient incubation of cultured hippocampal neurons in the absence of magnesium induces rhythmic and synchronized epileptiform-like activity". Scientific Reports 11 1 (2021): http://dx.doi.org/10.1038/s41598-021-90486-y.
    10.1038/s41598-021-90486-y
  4. Costa, Rui O.; Martins, Helena; Martins, Luís F.; Cwetsch, Andrzej W.; Mele, Miranda; Pedro, Joana R.; Tomé, Diogo; et al. "Synaptogenesis Stimulates a Proteasome-Mediated Ribosome Reduction in Axons". Cell Reports 28 4 (2019): 864-876.e6. http://dx.doi.org/10.1016/j.celrep.2019.06.080.
    Acesso aberto • Publicado • 10.1016/j.celrep.2019.06.080
  5. Pedro Afonso; Pasqualino De Luca; Rafael S. Carvalho; Luísa Cortes; Paulo Pinheiro; Barbara Oliveiros; Ramiro D. Almeida; Miranda Mele; Carlos B. Duarte. "BDNF increases synaptic NMDA receptor abundance by enhancing the local translation of Pyk2 in cultured hippocampal neurons". Science Signaling 12 586 (2019): eaav3577-eaav3577. https://doi.org/10.1126/scisignal.aav3577.
    10.1126/scisignal.aav3577
  6. Mele, M.; Costa R.O; Duarte, C.B.. "Alterations in GABAA-Receptor Trafficking and Synaptic Dysfunction in Brain Disorders.". Frontiers in Cellular Neuroscience (2019): http://europepmc.org/articles/PMC6416223.
    10.3389/fncel.2019.00077
  7. Salazar, Ivan; Mele, Miranda; Caldeira, Margarida; Costa, Rui; Correia, Bárbara; Frisari, Simone; Duarte, Carlos. "Preparation of Primary Cultures of Embryonic Rat Hippocampal and Cerebrocortical Neurons". BIO-PROTOCOL 7 18 (2017): http://dx.doi.org/10.21769/bioprotoc.2551.
    10.21769/bioprotoc.2551
  8. Mele, M.; Aspromonte, M.C.; Duarte, C.B.. "Downregulation of GABAAReceptor Recycling Mediated by HAP1 Contributes to Neuronal Death in In Vitro Brain Ischemia". Molecular Neurobiology 54 1 (2017): 45-57. http://www.scopus.com/inward/record.url?eid=2-s2.0-84953293603&partnerID=MN8TOARS.
    10.1007/s12035-015-9661-9
  9. Graciano Leal; Diogo Comprido; Pasqualino de Luca; Eduardo Morais; Luís Rodrigues; Miranda Mele; Ana R. Santos; et al. "The RNA-Binding Protein hnRNP K Mediates the Effect of BDNF on Dendritic mRNA Metabolism and Regulates Synaptic NMDA Receptors in Hippocampal Neurons". eneuro 4 6 (2017): ENEURO.0268-17.2017. https://doi.org/10.1523/ENEURO.0268-17.2017.
    10.1523/ENEURO.0268-17.2017
  10. Curcio, M.; Salazar, I.L.; Mele, M.; Canzoniero, L.M.T.; Duarte, C.B.. "Erratum to “Calpains and neuronal damage in the ischemic brain: The swiss knife in synaptic injury” (Progress in Neurobiology (2016) 147 (20) (S0301008216300090) (10.1016/j.pneurobio.2016.06.001))". Progress in Neurobiology 147 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84997683943&partnerID=MN8TOARS.
    10.1016/j.pneurobio.2016.08.004
  11. Curcio, M.*; Salazar, I.L.*; Mele, Miranda*(Co-Firs); Canzoniero, L.M.T.; Duarte, C.B.. "Calpains and neuronal damage in the ischemic brain: The swiss knife in synaptic injury". Progress in Neurobiology 143 (2016): 1-35. http://www.scopus.com/inward/record.url?eid=2-s2.0-84979684030&partnerID=MN8TOARS.
    10.1016/j.pneurobio.2016.06.001
  12. Vieira, M.M.; Schmidt, J.; Ferreira, J.S.; She, K.; Oku, S.; Mele, M.; Santos, A.E.; et al. "Multiple domains in the C-terminus of NMDA receptor GluN2B subunit contribute to neuronal death following in vitro ischemia". Neurobiology of Disease 89 (2016): 223-234. http://www.scopus.com/inward/record.url?eid=2-s2.0-84959360132&partnerID=MN8TOARS.
    10.1016/j.nbd.2015.11.007
  13. Mele, M.; Leal, G.; Duarte, C.B.. "Role of GABAAR trafficking in the plasticity of inhibitory synapses". Journal of Neurochemistry 139 6 (2016): 997-1018. http://www.scopus.com/inward/record.url?eid=2-s2.0-84990020943&partnerID=MN8TOARS.
    10.1111/jnc.13742
  14. Costa, João T.*; Mele, Miranda*(Co-Firs); Baptista, Márcio S.; Gomes, João R.; Ruscher, Karsten; Nobre, Rui J.; de Almeida, Luís Pereira; Wieloch, Tadeusz; Duarte, Carlos B.. "Gephyrin Cleavage in In Vitro Brain Ischemia Decreases GABAA Receptor Clustering and Contributes to Neuronal Death". Molecular Neurobiology 53 6 (2015): 3513-3527. http://dx.doi.org/10.1007/s12035-015-9283-2.
    10.1007/s12035-015-9283-2
  15. Santos, A.R.; Mele, M.; Vaz, S.H.; Kellermayer, B.; Grimaldi, M.; Colino-Oliveira, M.; Rombo, D.M.; et al. "Differential role of the proteasome in the early and late phases of BDNF-induced facilitation of LTP". Journal of Neuroscience 35 8 (2015): 3319-3329. http://www.scopus.com/inward/record.url?eid=2-s2.0-84923356181&partnerID=MN8TOARS.
    10.1523/JNEUROSCI.4521-14.2015
  16. Mele, M.; Ribeiro, L.; Inácio, A.R.; Wieloch, T.; Duarte, C.B.. "GABAA receptor dephosphorylation followed by internalization is coupled to neuronal death in in vitro ischemia". Neurobiology of Disease 65 (2014): 220-232. http://www.scopus.com/inward/record.url?eid=2-s2.0-84896313006&partnerID=MN8TOARS.
    10.1016/j.nbd.2014.01.019
  17. Caldeira, M.V.; Curcio, M.; Leal, G.; Salazar, I.L.; Mele, M.; Santos, A.R.A.; Melo, C.V.; et al. "Excitotoxic stimulation downregulates the ubiquitin-proteasome system through activation of NMDA receptors in cultured hippocampal neurons". Biochimica et Biophysica Acta - Molecular Basis of Disease 1832 1 (2013): 263-274. http://www.scopus.com/inward/record.url?eid=2-s2.0-84868560715&partnerID=MN8TOARS.
    10.1016/j.bbadis.2012.10.009
  18. Melo, C.V.; Mele, M.; Curcio, M.; Comprido, D.; Silva, C.G.; Duarte, C.B.. "BDNF Regulates the Expression and Distribution of Vesicular Glutamate Transporters in Cultured Hippocampal Neurons". PLoS ONE 8 1 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84872222727&partnerID=MN8TOARS.
    10.1371/journal.pone.0053793
  19. Lobo, A.C.; Gomes, J.R.; Catarino, T.; Mele, M.; Fernandez, P.; Inácio, A.R.; Bahr, B.A.; et al. "Cleavage of the vesicular glutamate transporters under excitotoxic conditions". Neurobiology of Disease 44 3 (2011): 292-303. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053269066&partnerID=MN8TOARS.
    10.1016/j.nbd.2011.07.010
Capítulo de livro
  1. D. Comprido, M. Mele, G. Leal, J. Ferreira, C.B. Duarte. "Transporte axonal.". In Neurociências. Capítulo 3. Editores: C.R. Oliveira, A.C. Rego e C.B. Duarte. Lidel, Lisboa, 37-56. Portugal: Lidel, Lisboa, 2017.
    Publicado
Poster em conferência
  1. Rodrigues, Catarina; Mele, Miranda; Duarte, Carlos B.. Autor correspondente: Rodrigues, Catarina. "Pathogenic mechanisms mediated by anti-GABAAR-autoantibodies in autoimmune epilepsy". Trabalho apresentado em 18th PDBEB symposium, 2024.
  2. Mendes, Candida; Marques, Carla; Mota, Sandra; Afonso, Mariana; Alves, André; Amaral, Sandra; Candeias, Emanuel; et al. "GreenLabs @CIBB - "Collection Points" - Reuse and Recycling". Trabalho apresentado em GreenLabs Portugal Symposium: Promoting sustainability in Research, 2023.
  3. Alarico, Susana; Mele, Miranda; Simões, Isaura. "GreenLabs@CIBB - One path for sustainable research". Trabalho apresentado em EU-LIFE, 2023.
  4. Rodrigues, Catarina; Carvalho, Inês V. ; Bento, Conceição; Dalmau, Josep; Duarte, Carlos B.; Mele, Miranda. "Modulation of neuronal activity and GABAergic synapses by autoantibodies from epileptic patients". Trabalho apresentado em 35º Encontro Nacional de Epileptologia, 2023.
  5. Masella, Gianluca; Francisca Silva; Mele, Miranda; Carlos B. Duarte; Santos, Monica. "NT3/TrkC-dependent regulation of NMDA receptors: implications for fear extinction". Trabalho apresentado em 8th European Synapse Meeting, 2022.
  6. Claudia Corso; Giorgio Belperio; Cinzia Miarelli; Catarina Rodrigues; Filipe V. Duarte; Rui O. Costa; Carlos B. Duarte; Mele, Miranda. "K+-Cl- cotransporter (KCC2) activation as a novel therapeutic strategy for epilepsy". Trabalho apresentado em 8th European Synapse Meeting, 20th-21st of October 2022. Coimbra, 2022.
  7. Masella, Gianluca; Francisca Silva; Mele, Miranda; Duarte, Carlos B.; Santos, Monica. Autor correspondente: Santos, Monica. "Neurotrophin-3/TrkC contribution to fear extinction and regulation of glutamatergic synapses". Trabalho apresentado em FENS Forum 2022, 2022.
  8. Filipe Valente Duarte; Belperio, Giorgio; Cinzia Miarelli; Giovanna Lombardi; Duarte, Carlos B.; Costa RO; Mele, Miranda. "Activation of K+-Cl--cotransporter (KCC2) as a novel therapeutic approach for epilepsy". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience ¿ SPN2021, 2021.
  9. Masella, Gianluca; Andretta, Emanuela; Mele, Miranda; Duarte, Carlos B.; Santos, Monica. Autor correspondente: Santos, Monica. "NT3/TrkC signaling controls the composition and the synaptic abundance of AMPA and NMDA receptors.". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  10. Mele, Miranda. "K+-Cl¿cotransporter (KCC2) as a novel therapeutic target for epilepsy, ESN Conference". Trabalho apresentado em First Virtual ESN Conference “Future perspectives for European neurochemistry – a young scientists conference, 2021.
  11. Mele, Miranda. "K+-Cl--cotransporter (KCC2) as a novel therapeutic strategy for epilepsy, 33e ENE ¿ Congress, LPCE". Trabalho apresentado em 33e ENE – Congresso Virtual da LPCE, 2021.
  12. Filipe Duarte, Giorgio Belperio, Cinzia Miarelli , Giovanna Lombardi, Carlos B. Duarte and Rui O. Costa, Miranda Mele. "Activation of K+-Cl--cotransporter (KCC2) as a novel therapeutic approach for epilepsy. SPN". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience (SPN 2019), 2021.
  13. Mele, Miranda; Filipe V. Duarte, Ricardo Vieira, Andrea Barberis, Carlos B. Duarte. "Alteration of GABAA Receptor membrane dynamics in Epilepsy. SPN". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience (SPN 2019), 2021.
  14. De Luca Pasqualino, Afonso Pedro, Carvalho Rafael, Pinheiro Paulo, Mele Miranda, Duarte Carlos. "BDNF upregulates synaptic NMDA receptors by enhancing local translation of Pyk2 in cultured hippocampal neurons. At 23rd ESN Biennial Meeting, 1st-4th September, 2019 Milano, Italy". Trabalho apresentado em 23rd ESN Biennial Meeting, 1st-4th September, 2019 Milano, 2019.
  15. Rafael S. Carvalho, Pedro Afonso, Miranda Mele, Carlos Duarte.. "REGULATION OF NMDA RECEPTOR SURFACE DYNAMICS BY BDNF IN CULTURED HIPPOCAMPAL NEURONS. Society for Neuroscience (SPN 2019). May 30 to June 1, 2019 Lisbon, Portugal". Trabalho apresentado em Society for Neuroscience (SPN 2019). May 30 to June 1, 2019 Lisbon, Portugal, 2019.
  16. Pasqualino De Luca, Pedro Afonso, Miranda Mele, Paulo Pinheiro, Carlos B. Duarte.. "BDNF INCREASES SYNAPTIC EXPRESSION OF GLUN2B-CONTAINING NMDAR IN CULTURED HIPPOCAMPAL NEURON. Portuguese Society for Neuroscience (SPN 2019). May 30 to June 1, 2019 Lisbon, Portugal". Trabalho apresentado em Portuguese Society for Neuroscience (SPN 2019). May 30 to June 1, 2019 Lisbon, Portugal, 2019.
  17. M. Mele , R. Vieira , R. Barletta , A. Luciunaite , A. Barberis , C. B. Duarte. "Alteration of GABAA Receptor trafficking in status epilepticus. At the 11th FENS Forum of Neuroscience 7-11 July, 2018. Berlin,Germany". Trabalho apresentado em 11th FENS Forum of Neuroscience 7-11 July, 2018. Berlin,Germany, 2018.
  18. Ricardo Vieira, Roberta Barletta, Asta Luciunaite, Andrea Barberis, Carlos B. Duarte.. "ALTERATION OF GABAA RECEPTOR TRAFFICKING IN STATUS EPILEPTICUS. 7th ISN Special Neurochemistry Conference on SYNAPTIC FUNCTION AND DYSFUNCTION IN BRAIN DISEASES. Coimbra, Portugal 1 - 4 June 2016". Trabalho apresentado em 7th ISN Special Neurochemistry Conference on SYNAPTIC FUNCTION AND DYSFUNCTION IN BRAIN DISEASES. Coimbra, Portugal 1 - 4 June 2016, 2016.
  19. Pasqualino De Luca, Pedro Afonso, Miranda Mele, Paulo Pinheiro, Carlos Duarte.. "BDNF UPREGULATES SYNAPTIC EXPRESSION OF GLUN2B-CONTAINING NMDAR IN CULTURED HIPPOCAMPAL NEURON. 7th ISN Special Neurochemistry Conference on SYNAPTIC FUNCTION AND DYSFUNCTION IN BRAIN DISEASES. Coimbra, Portugal 1 - 4 June 2016". Trabalho apresentado em 7th ISN Special Neurochemistry Conference on SYNAPTIC FUNCTION AND DYSFUNCTION IN BRAIN DISEASES. Coimbra, Portugal 1 - 4 June 2016, 2016.
  20. Rui O. Costa, Helena Martins, Luís F. Martins, Joana R. Pedro, Miranda Mele, Andrzej Cwetsch, Laura Cancedda, Ramiro D.. "MECHANISMS UNDERLYING RIBOSOMAL REGULATION IN AXONAL DEVELOPMENT. 7th ISN Special Neurochemistry Conference on SYNAPTIC FUNCTION AND DYSFUNCTION IN BRAIN DISEASES. Coimbra, Portugal 1 - 4 June 2016". Trabalho apresentado em Conference on SYNAPTIC FUNCTION AND DYSFUNCTION IN BRAIN DISEASES. Coimbra, Portugal 1 - 4 June 2016, 2016.
  21. Mele, Miranda; J Costa, M.C. Aspromonte, Duarte CB.. "DOWNREGULATION OF GABAERGIC SYNAPSES AND NEURONAL DEATH IN CEREBRAL ISCHEMIA. XIV Meeting of the Portuguese Society for Neurosciences (SPN) 2015, Póvoa de Varzim, Portugal 4-5 June 2015". Trabalho apresentado em XIV Meeting of the Portuguese Society for Neurosciences (SPN) 2015, Póvoa de Varzim, Portugal 4-5 June 2015, 2015.
  22. Mele, Miranda; M.C. Aspromonte; Duarte CB.. "Alterations of GABAA receptor trafficking in the Oxygen/Glucose Deprivation in vitro model of cerebral ischemia. SFN 2014 meeting, Washington DC, USA, November 15-19th, 2014". Trabalho apresentado em SFN 2014 meeting, Washington DC, USA, November 15-19th, 2014, 2014.
  23. Mele, Miranda; Mele M; Ribeiro L; Duarte CB.. "Role of GABAA receptors (de)phosphorylation inischemia induced cell death. Portugal. EMBO Young Scientists’ Forum 15–16 July 2013 Lisbon, Portugal.". Trabalho apresentado em EMBO Young Scientists’ Forum 15–16 July 2013 Lisbon, Portugal., 2013.
  24. Mele, Miranda. "MODULATION OF GABAA RECEPTOR SURFACEDISTRIBUTION IN IN-VITRO BRAIN ISCHEMIA. 2012. X Center for Neuroscience and Cell Biology meeting. Coimbra, Portugal.". Trabalho apresentado em X Center for Neuroscience and Cell Biology meeting. Coimbra, Portugal., 2012.
  25. Mele, Miranda; Duarte CB.. "MODULATION OF GABAA RECEPTOR EXPRESSION IN IN-VITRO BRAIN ISCHEMIA.Detalhes do Evento: 8th FENS forum of Neuroscience,July 14th-18th 2012. FENS .Barcelona, Spain.". Trabalho apresentado em 8th FENS forum of Neuroscience,July 14th-18th 2012. FENS .Barcelona, Spain., 2012.
  26. Mele, Miranda; Duarte, C.B. "Changes in GABAA receptor expression in in-vitro brain ischemia. 8th IBRO World Congress of Neuroscience.14th-18th July 2011IBRO.Florence, Italy.". Trabalho apresentado em 8th IBRO World Congress of Neuroscience.14th-18th July 2011IBRO.Florence, Italy., 2011.
  27. Santos AR; Mele M; Kellermayer B; Comprido D; Manadas BO; Duarte CB.. "Effect of BDNF on the ubiquitin-proteaosme system on hippocampal neurons.2010 EMBO Workshop Proteolysis and Neurodegeneration.EMBO. Madrid, Spain". Trabalho apresentado em EMBO Workshop Proteolysis and Neurodegeneration.EMBO. Madrid, Spain 2010, 2010.
  28. Santos AR; Mele M; Kellermayer B; Comprido D; Manadas BO; Duarte CB. "Effect of BDNF on the ubiquitin-proteasome system on hippocampal neurons. 2009. Society for Neuroscience 39th Annual Meeting, Chicago, IL, EUA. SFN.Chicago.". Trabalho apresentado em Society for Neuroscience 39th Annual Meeting, Chicago, IL, EUA. SFN.Chicago., 2009.
  29. Santos AR; Mele M; Kellermayer B; Manadas BO; Garbis S, Fountoulakis M; Duarte CB.. "Effect of BDNF on Ubiquitin-Proteasome System in hippocampal cultured neurons 2008.EMBO Practical Course on Ubiquitin and SUMO. Split, Croatia.". Trabalho apresentado em EMBO Practical Course on Ubiquitin and SUMO. Split, Croatia., 2008.
    10.1158/1538-7445.am2012-3928
Pré-impressão
  1. L. Salazar, Ivan; Curcio, Michele; Mele, Miranda; Vetrone, Rossela; Frisari, Simone; O. Costa, Rui; V. Caldeira, Margarida; J Trader, Darci; B.Duarte, Carlos. "Activation of the proteasome 20S Core particle prevents neuronal death induced by oxygen- and glucose deprivation in cultured neurons". 2024. http://dx.doi.org/10.1101/2024.05.15.594129.
    10.1101/2024.05.15.594129
Resumo em conferência
  1. Martínez-Rodríguez, Elena; Andretta, Emanuela; Mele, Miranda; Santos, M. "Role of NT3-TrkC in the regulation of fear". Trabalho apresentado em 2020 BIAL Foundation symposium - Behind and Beyond the Brain, Porto, 2020.
Tese / Dissertação
  1. Mele, Miranda. "Modulation of GABAA receptors in cerebral ischemia: alterations in receptor trafficking coupled to neuronal death after oxygen/glucose deprivation". Doutoramento, Universidade de Coimbra Departamento de Ciências da Vida, 2013.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2024/04/17 Epilepsy: is it an autoimmune disease? DCV.talks (Departamento de Ciências da Vida da Universidade de Coimbra)
University of Coimbra (Coimbra, Portugal)
2021/12/03 Alteration of GABAA Receptor membrane dynamics in Epilepsy 3) XVII Meeting of the Portuguese Society for Neuroscience, which will be held in Coimbra, from 1 - 3 December, 2021.
SPN (Coimbra, Portugal)
2021/03/12 K+-Cl--cotransporter (KCC2) as a novel therapeutic strategy for epilepsy 33 ENE (Encontro Nacional de Epileptologia)
LPCE -Liga Portuguesa Contra A Epilepsia (Coimbra, Portugal)
2019/05/10 Alteration of GABAA receptor dynamics in epilepsy Neuroscience and Disease. At the Neuroscience and Disease – Retreat on May 10, May 10th, 2019 - Casa das Artes, Miranda do Corvo, Portugal Neuroscience and Disease – Retreat on May 10, May 10th, 2019 - Casa das Artes, Miranda do Corvo, Portugal
Center for Neuroscience and cell Biology of Coimbra (Miranda do Corvo, Portugal)
2019 ALTERATION OF GABAA RECEPTOR TRAFFICKING IN STATUS EPILEPTICUS. At XVI Meeting of the Portuguese Society for Neuroscience (SPN 2019). May 30 to June 1, 2019 Lisbon, Portugal XVI Meeting of the Portuguese Society for Neuroscience (SPN 2019)
Portuguese Society for Neuroscience (SPN) (Lisbon, Portugal)
2016/06 DYSREGULATION OF GABAERGIC SYNAPSES IN BRAIN ISCHEMIA: MULTIPLE MECHANISMS CONTRIBUTING TO NEURONAL DEMISE. 7th ISN Special Neurochemistry Conference on SYNAPTIC FUNCTION AND DYSFUNCTION IN BRAIN DISEASES. Coimbra, Portugal 1 - 4 June 2016 7th ISN Special Neurochemistry Conference on SYNAPTIC FUNCTION AND DYSFUNCTION IN BRAIN DISEASES. Coimbra, Portugal 1 - 4 June 2016
International Society for Neurochemistry (Coimbra, Portugal)
2016/03/11 Alteration of GABAA Receptor trafficking in status epilepticus. 28º Encontro Nacional de Epileptologia -11 March 2016, Porto 2016 28º Encontro Nacional de Epileptologia
LPCE-Liga Portuguesa Contra a Epilepsia (Porto, Portugal)
2014/06/27 Modulation of GABAA receptors in cerebral ischemia: alterations in receptor trafficking coupled to neuronal death after oxygen glucose deprivation. Center for Neuroscience and Cell Biology, seminars summer section 2014, June 27th 2014. Center for Neuroscience and Cell Biology, seminars summer section 2014
Center for Neuroscience and Cell Biology (Coimbra, Portugal)
2013 Modulation of GABAA receptors in cerebral ischemia: alterations in receptor trafficking coupled to neuronal death after oxygen/glucose deprivation. XI Center for Neuroscience and Cell Biology meeting. Coimbra, Portugal. XI Center for Neuroscience and Cell Biology meeting. Coimbra, Portugal.
Center for Neuroscience and Cell Biology, Coimbra, Portugal. (Coimbra, Portugal)
2011 BDNF-induced changes in the proteome of dendrites: protein synthesis vs. protein degradation. 2011, 8th IBRO World Congress of Neuroscience. Florence, Italy. 8th IBRO World Congress of Neuroscience
IBRO (Itália)
2011 Modulation of GABAA receptor expression in in vitro ischemia.Portugal. IX Center for Neuroscience and Cell Biology Meeting. Coimbra, Portugal. IX Center for Neuroscience and Cell Biology Meeting. Coimbra, Portugal.
Center for Neuroscience and Cell Biology, Coimbra (Coimbra, Portugal)
2011 The ubiquitin­proteasome system is regulated by BDNF at hippocampal synapses”. Portugal, IX Center for Neuroscience and Cell Biology Meeting. Coimbra. IX Center for Neuroscience and Cell Biology Meeting.
Center for Neuroscience and Cell Biology of Coimbra (Coimbra, Portugal)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2023/01/01 - 2023/07/01 Modulation of Rat Hippocampal Neuronal Network Activity by Anti-GABAA Receptor Autoantibodies
Orientador
 Biochemistry (Licenciatura/Bacharelato)
EuroFaculty Vilnius, Lituânia
2021/03 - 2022/12 ACTIVATION OF NEURONAL K+-Cl- COTRANSPORTER KCC2 DURING STATUS EPILEPTICUS: POSSIBLE IMPACT ON NEUROTRAL ACTIVITY
Orientador
 Master in Biology (Mestrado)
Università degli Studi del Sannio, Itália
2021/09/01 - 2022/09/30 Autoimmune epilepsy and GABAergic neurotransmission
Orientador
 Cellular and Molecular Biology (Mestrado)
Universidade de Coimbra, Portugal
2020/03 - 2021/02 Novel roles for the KCC2 co-transporter in axons: regulation of chloride homeostasis and growth cone development.
Orientador
 Master Degree in Biology (Mestrado)
Università degli Studi del Sannio, Itália
2019/09 - 2020/12 GABAERGIC SYNAPSES REORGANIZATION AND DYSFUNCTION IN IN VITRO EPILEPSY
Orientador de Beatriz Vinhas Maio
 Master in Cellular and Molecular Biology (Mestrado)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2018/09/01 - 2019/09 ALTERATIONS OF NEURONAL K+-Cl- COTRANSPORTER KCC2 DURING STATUS EPILEPTICUS: POSSIBLE IMPACT ON GABAergic NEUROTRANSMISSION
Orientador de Cinzia Miarelli
 laurea magistrale in Biologia; mestrado em Cellular and Molecular Biology (Mestrado)
Università degli Studi del Sannio, Itália

Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2017/09/01 - 2018/09 Regulation of NMDA receptors by BDNF in cultured neurons
Coorientador
 Master in Cellular and Molecular Biology (Mestrado)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2016/09/01 - 2017/09 Pharmacological characterization of an in vitro model of status epilepticus
Coorientador
 Bioquímica
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2015/09/01 - 2016/09 Regulation of synaptic transmission by BDNF: effects on NMDA receptor-mediated mEPSC
Coorientador de Pasqualino De Luca
 Master in Biology; Master in Cellular and Molecular Biology (Mestrado)
Università degli Studi del Sannio, Itália

Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2014/09/01 - 2015/09 Alteration of GABA AR trafficking in epilepsy
Orientador
 mestrado em Investigação Biomédica (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2013/09/01 - 2014/09 Alterations of GABAA Receptor trafficking in cerebral ischemia: the Huntingtin­associated protein 1 (HAP1)
Coorientador de Maria Cristina Aspromonte
 Master Student in Biology and Master in Cellular and Molecular Biology (Mestrado)
2012/05 - 2012/07 Alterations of GABAA Receptor trafficking in in vitro cerebral ischemia.
Coorientador
 Degree in Biomedical Sciences (Licenciatura/Bacharelato)
Universidade do Algarve, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2023/11/21 - 2023/11/26 Organization and moderator of the activity: ¿Un viaggio nei meccanismi della memoria¿. This activity was part of the science dissemination event: XXXVII edition of ¿Futuro Remoto¿ at the Città della Scienza, Napoli, Italy (2023/11/26 - 2023/11/26)
Outro (Coorganizador)
2020/12/11 - 2020/12/11 Seminar host: Coordinated excitatory and inhibitorysynaptic plasticity at dendriticglutamatergic and GABAergic synapsesAr the Center for Neuroscience and Cellbiology of the University of Coimbra,PortugalSeminar (2020/12/11 - 2020/12/11)
Seminário (Coorganizador)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2010 - Atual Collaborator in “Ciência Viva” programme, at the Center for Neuroscience and Cell Biology (CNC), University of Coimbra
Outro
 Ciência Viva programme
2009/10/06 - 2029/10/09 Advanced course of Cell Biology
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2009/09/29 - 2029/10/02 Advanced course of Biostatistics
Outro
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2022/09/20 - 2022/09/21 8th European Synapse Meeting, 20th-21st of October 2022. Coimbra
Conferência
 8th European Synapse Meeting
2021/05/25 - 2021/05/26 ESN Conference “Future perspectives for European neurochemistry – a young scientist’s conference
Conferência
2021/03/12 - 2021/03/13 33 ENE (Encontro Nacional de Epileptologia) 33 ENE (Encontro Nacional de Epileptologia)
2020/01/23 - 2020/01/24 Mini-symposium - The neurobiology of socio-sexual behavior
Simpósio
 The neurobiology of socio-sexual behavior
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/12 - 2019/12 Training in Laboratory Animal Science; Level B course (40 hours). DAGV accreditation for carrying out procedures on animals in accordance with paragraph 5 of article No. 31 of Decree-Law No. 113/2013 of 7 August, "protection of animals used for scientific purposes
Outro
 Training in Laboratory Animal Science
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2014/10 - 2014/10 Course in Laboratory Animal Science, LAS Course, FELASA cat B.
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2012/12/04 - 2012/12/06 Advanced fluorescence microscopy workshop. Training content: Widefield fluorescence microscopy; Confocal Microscopy (LSM 700); Structured Ilummination Microscopy (APOTOME); Zen imaging software. Coimbra, Portugal.
Oficina (workshop)
 Advanced fluorescence microscopy workshop
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2012/04/13 - 2012/04/13 Technical Seminar: “RNA World: not so small”
Seminário
 RNA World: not so small
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2010/03/08 - 2010/03/12 Advanced course of Oncobiology
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2010/03/02 - 2010/03/05 Advanced course of Biomedical Magnetic Resonance: Molecular Imaging and Metabolism
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2010/02/22 - 2010/02/26 Advanced course of Molecular Neuroscience
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2010/02/01 - 2010/02/12 Advanced course of Drug Development (MIT-Portugal)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2010/01/25 - 2010/01/29 Advanced course of Neurodegenerative Disorders
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2010/01/11 - 2010/01/15 Advanced course of Gene Therapy and Nuclear Biology
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2010/01/04 - 2010/01/08 Advanced course of Immunology
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2009/12/15 - 2009/12/18 Advanced course of Science Communication
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2009/12/07 - 2009/12/11 Advanced course of Microbiology
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2009/11/30 - 2009/12/04 Advanced course of Systems Biology
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2009/11/23 - 2009/11/27 Advanced course of Mitochondrial Bioenergetics
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2009/10/26 - 2009/10/30 Advanced course of Vascular Biology
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2009/10/12 - 2009/10/23 Advanced course of Molecular Biotechnology
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2024/09/13 Cellular and molecular pathogenic mechanisms triggered by anti-CASPR1 autoantibodies
Arguente principal
 Vítor Teixeira Pereira Bueno (Mestrado)
Universidade de Coimbra, Portugal
2024/02/26 NT3-TrkC system in the regulation of GABAergic synapses and inhibition/excitation balance. João Videira Duarte Henriques (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2023/10/23 ROLE OF GLUN2B-CONTAINING NMDARS ON NETWORK ACTIVITY AND SYNAPSE MATURATION THROUGH THE INTERACTION WITH EPHA4
Arguente principal
 João Gonçalves Martins (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2022/09/20 MODULATION OF GABAERGIC SYNAPSES BY AUTOANTIBODIES FROM EPILEPTIC PATIENTS
Orientador
 Catarina Rodrigues (Mestrado)
Universidade de Coimbra, Portugal
2020/12/10 EXPLORING THE PATHOGENIC MECHANISMS ELICITED BY ANTIBODY-MEDIATED LOSS OF CASPR2 IN AUTOIMMUNE SYNAPTIC ENCEPHALITIS
Arguente principal
 Ana Maria da Graça Fernandes Vasconcelos (Mestrado)
Universidade de Coimbra, Portugal
2020/11/01 Electrophysiological validation and characterization of pharmacological compounds targeting GluK2/GluK5 kainate receptors
Arguente principal
 Ana Sofia Alberto e Silva (Mestrado)
Universidade de Coimbra, Portugal
2020/02/28 PhD Thesis: The role of purinergic receptors in hippocampal mossy fiber sprouting during epileptogenesis
Arguente
 Xinli Xu (Doutoramento)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2017/09/17 Master thesis; ARHGAP8 co-regulates excitatory and inhibitory synapse function. University of Coimbra, Faculty of science and technology, Portugal
Arguente principal
 Inês Baião Santos (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2015/09/11 Master Thesis: "Impact of CXCL12 inhibition on gene expression patterns after stroke". University of Coimbra, Faculty of science and technology, Portugal, Portugal
Arguente principal
 Ana Rita Pombo Antunes (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2015/09 Master Thesis :Alteration of GABAA receptor trafficking in epilepsy
Orientador
 Ricardo da Costa Barbedo Vieira (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2015/07/21 Thesis: Establishment of NETosis video microscopy as well as the influence of hormones on the NK-cell function
Arguente principal
 Bárbara Catarina Gonçalves Correia (Outro)
Universidade de Aveiro Departamento de Biologia, Portugal

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2020/03/30 - Atual Frontiers in Cellular Neuroscience (1662-5102) Frontiers Media SA
2018 - Atual Heliyon (2405-8440) Elsevier
2016 - Atual Journal of Cerebral Blood Flow & Metabolism SAGE
2016 - Atual International Journal of Immunopathology and Pharmacology SAGE
2015 - Atual Neurochemical Research Springer
2012 - Atual International Journal of Neuropharmacology (0375-9458) Elsevier

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2022/02/26 - Atual Dysfunction of GABAergic Synapse in Brain Disorders Biomedicina Molecular (Mestrado integrado) Universidade de Aveiro, Portugal
2022/02/10 - Atual Inhibitory Synapses : Function and Plasticity Experimental Biology and Biomedicine (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Coimbra, Portugal
2012 - Atual Cell Regulatin Master Program in Cellular and Molecular Biology (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2023/11/17 - 2023/11/17 Epilepsy Biomedicina Molecular (Mestrado integrado) Universidade de Aveiro, Portugal
2021/03/22 - 2021/03/26 Inhibitory synapse function and plasticity Biologia Experimental e Biomedicina (Doutoramento) Universidade de Coimbra, Portugal
2020/03/27 - 2020/03/27 lecturer: Miranda Mele. Class: Animal cell culture and mitosis phases. Advanced Course "Molecular Biology: From Gene to Protein" Session 9: Cell culture and immunocytochemistry Date: 20 March 2020 (Theoretical / Practical) Oliveira do Bairro Secondary School (ESOB) (Ensino secundário) Secundária de Oliveira do Bairro (ESOB), Portugal
2019/10/04 - 2019/10/04 lecturer: Miranda Mele. Class: Functional organization of the nervous system. Advanced Course: "Neuroscience" . Session 1: Basic concepts of Neuroscience. 4 October 2019 (Theoretical). Adolfo Portela Secondary School, Águeda. (Ensino secundário) Escola Secundária Adolfo Portela, Águeda, Portugal
2019/04/30 - 2019/04/30 Lecture: Miranda Mele. Inhibitory Synapse function and plasticity. Synapse function and Structures Course 2019. PhD Programme in Experimental Biology and Biomedicine (PDBEB, Center for Neuroscience and Cell Biology, University of Coimbra). 30 of April 2019 biologia experimental e biomedicina (Doutoramento) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/03/27 - 2019/03/27 Two Lectures: Miranda Mele. Epilepsy. NEUROBIOLOGY AND DISEASE course. Master in Cellular and Molecular Biology. Faculty of science and technology, University of Coimbra. 27 of March 2019 Biologia Celular e Molecular (Mestrado integrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018/05/25 - 2018/05/25 Lecture: Miranda Mele. Dysfunction of GABAergic synapses in status epilepticus (SE): structural synaptic reorganization and changes in GABAA receptor dynamics. Seminar for the students of the MIM (Integrated Masters in Medicine). Faculty of Medicine, University of Coimbra. Portugal. 25 of May 2018. Medicine (Mestrado integrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2018/05/24 - 2018/05/24 Lecture: Miranda Mele. Alteration of GABAA Receptor trafficking in status epilepticus. Seminar for the students of the Master in Biomedical Engineering. Faculty of science and technology, University of Coimbra. Portugal. 24 of May 2018 Biomedical Engineering (Mestrado integrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018/04/11 - 2018/04/11 lecturer: Miranda Mele. Class: Functional organization of the nervous system. Advanced Course: "Neuroscience" . 11 April 2018 (Theoretical). Agrupamento de Escolas de Anadia Secondary School, Anadia. (Ensino secundário) Agrupamento de Escolas de Anadia, Portugal
2016 - 2016 Lecture: Dysfunction of GABAergic synapses in status epilepticus: changes in GABAA receptor dynamics. Neurodevelopmental Disorders Course 2016, PhD Programme in Experimental Biology and Biomedicine (PDBEB, Center for Neuroscience and Cell Biology, University of Coimbra) Experimental Biology and Biomedicine (Doutoramento) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Membro de associação

Nome da associação Tipo de participação
2018 - Atual Portuguese Society for Neuroscience Effective Member
2015 - Atual Portuguese Biochemistry Society (SPB) Member
2014 - Atual Liga Portuguesa Contra a Epilepsia (LPCE) Member

Tutoria

Tópico Nome do aluno
2022/07/01 - Atual High-content screening of a novel therapy for Machado-Joseph disease in reporter gene-edited induced pluripotent stem cells. Frederico Mendes e Pena
2021/06/01 - Atual THE PSYCHOBIOME UNVEILING THE ROLE OF GUT DYSBIOSIS IN SCHIZOPHRENIA Ana Raquel Pereira Santos
2021/06/01 - Atual Targeting class I and II histone deacetylases as therapeutic strategy to treat mitochondrial dysfunction in Alzheimer’s disease Daniela Marinho
2022/01 - 2022/07 Detection and characterization of autoantibodies present in serum samples from epileptic patients Alice Vieira
2019/10/01 - 2019/11/30 Internship in Neuroscience (PhD student at the second year of international doctoral study in medical and pharmaceutical science). Sylwia Lewoniewska
2019/05/01 - 2019/08/14 Post-graduation internship in Neuroscience. Giovanna Lombardi
2018/07 - 2018/08 Supervision for an internship in Neuroscience. Mireia Cuesta
2018/04/09 - 2018/07/09 Supervision for an internship In Neuroscience (Student in Laboratory Medicine (fifth year), MedicalUniversity of Bialystok, Poland. Sylwia Lewoniewska
2015/06 - 2015/09 Supervision of Internship in Neuroscience (Master Student in Biochemistry, University of Vilnius, Lithuania). Asta Luciunaite
2015/03 - 2015/07 Supervision of the post-graduation internship . Roberta Barletta
2014/01 - 2014/09 Supervision of Liliana Nisa internship (Student of the BSc in Biochemistry, University of Coimbra, Portugal) Liliana Nisa
Distinções

Prémio

2023 Honorable Mention awarded for the best communication presented at the 2023 National Meeting of Epileptology.
Liga Portuguesa Contra a Epilepsia , Portugal
2023 IBRO Parenthood Grant award
International Brain Research Organization, França
2019 SPN scholarship to participate in the SPN 2019 meeting
Portuguese Society for Neuroscience (SPN)/Sociedade Portuguesa de Neurociências (SPN), Portugal
2019 Scientific Incentive Grant 2019 -Portuguese Epilepsy foundation (LPCE)
Liga Portuguesa Contra a Epilepsia , Portugal
2017 FENS-IBRO/PERC travel grant for the FENS Forum 2018 in Berlin (7 – 11 July 2018)
2015 EMBO short term fellowship (EMBO ASTF 182-2015) for the project “Dynamics of GABAA receptor surface expression in Status Epilepticus.”
Gesellschaft zur Förderung der Lebenswissenschaften Heidelberg GmbH, Alemanha
2014 Scientific Incentive Grant 2014-Portuguese Epilepsy foundation (LPCE)
Liga Portuguesa Contra a Epilepsia , Portugal

Outra distinção

2020 Employment Stimulus (CEEC- Individual – 3th Edition)
Fundação para a Ciência e a Tecnologia, Portugal
2009 PDBEB PhD fellowship
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2007 ERASMUS PLACEMENT fellowship
Università degli Studi del Sannio, Itália