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Bachelor of Medicinal Biotechnology from the School of Health of the Polytechnic Institute of Porto, and Master of Biomedical Research from the Faculty of Medicine of the University of Coimbra. Completed a basic Laboratory Animal Science (MLAS) course at the Center for Neuroscience and Cell Biology of the University of Coimbra. Currently, I am a first-year PhD student in Clinical Research and Health Services at the Faculty of Medicine of the University of Porto. My academic journey is marked by several curricular internships, based on the evolution of my skills in scientific research. My bachelor's degree final internship was at the Interdisciplinary Center of Marine and Environmental Research (CIIMAR), where I acquired skills in cell culture and bioactivity assays. Additionally, the curriculum of the Master's in Biomedical Research includes three short-term internships in laboratories and areas of interest to the students. Thus, this choice aimed to align with my professional goals: at the Institute of Biomedicine of the University of Aveiro (iBiMED), where I was able to follow a microbiological study in animal models to consolidate the knowledge acquired in MLAS; at CIIMAR, where I developed a small project to investigate the potential antitumor activity of actinobacteria extracts, deepening techniques in cell culture and bioactivity assays; at the Center for Research in Health Technologies and Services (CINTESIS), where I had my first contact with pharmacometrics. In particular, this last internship opened the doors to my future in scientific research, with the development of my first work in pharmacometrics, culminating in the publication of my first scientific article. Since April 2022, I have been part of the PerMed research group at CINTESIS, first as a research intern and, since March 2024, as a research fellow under the Guest Chair in Oncology Research. My interest in pharmacometrics has been growing steadily, especially with my master's thesis (also developed in the PerMed group, CINTESIS), which focused on understanding interactions and sources of variability among patients through a population pharmacokinetic study of salbutamol using pharmacological modeling software such as Monolix and GastroPlus. Since then, I have been working on several projects focused on pharmacometrics for precision medicine. This dedication has resulted in several publications, including three articles derived from the study conducted in my master's thesis. To acquire advanced training in pharmacometrics, I applied to the PharMetrX Training+ PhD Program, which I am undertaking during the first year of my PhD. At this point, I have already completed two modules, taught in person at Freie Universitat Berlin and Universitat Potsdam in Germany. In addition to all this, as I have always sought to be actively engaged in the scientific community, I have two relevant participations in scientific congresses: a poster presentation at IJUP and an oral presentation at the 54th Meeting of the Portuguese Pharmacology Society. I also participated as a member of two organizing committees: Fórum Medicina de Precisão em Oncologia and LoginBiotech. Furthermore, I have had several participations in events, and have also submitted an abstract for poster presentation at the Population Approach Group Europe (PAGE), an annual meeting that brings together the scientific community with an interest in pharmacometrics. I am part of the editorial panel of the journal Mathematical Biosciences and Engineering (AIMS Press). Lastly, based on the knowledge acquired in pharmacometrics over the past two years, I have taught two workshops in this area at the Summer and Winter Schools of the Faculty of Medicine of the University of Porto.
Identificação

Identificação pessoal

Nome completo
Lara Filipa Marques

Nomes de citação

  • Marques, Lara

Identificadores de autor

Ciência ID
C212-E96B-A17F
ORCID iD
0000-0002-7003-4957

Endereços de correio eletrónico

  • lara.marques2010@hotmail.com (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Biotecnologia Médica - Biotecnologia Aplicada à Saúde

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Francês Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1)
Formação
Grau Classificação
2023 - 2028
Em curso
Investigação Clínica e em Serviços de Saúde (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2024/03 - 2024/09
Em curso
PharMetrX Training+ PhD Program (Outros)
Freie Universität Berlin, Alemanha
2021 - 2023
Concluído
Investigação Biomédica (Mestrado)
Especialização em Oncobiologia
Universidade de Coimbra Faculdade de Medicina, Portugal
"Population Pharmacokinetic Study Involving Different Salbutamol Formulations" (TESE/DISSERTAÇÃO)
19
2021/11 - 2021/11
Concluído
Modular Training in Laboratory Animal Science (Outros)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
15
2018 - 2021
Concluído
Biotecnologia Medicinal (Licenciatura)
Instituto Politecnico do Porto Escola Superior de Tecnologia da Saúde do Porto, Portugal
"Evaluation of phycotoxin degradation by bivalve-associated bacteria" (TESE/DISSERTAÇÃO)
16
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2022/06/01 - 2024/05/31 Estagiário de Investigação (Investigação) Centro de Investigação em Tecnologias e Serviços de Saúde, Portugal
Universidade do Porto Faculdade de Medicina, Portugal
2022/05/01 - 2022/05/31 Estagiário de Investigação (Investigação) Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
2022/04/01 - 2022/04/30 Estagiário de Investigação (Investigação) Centro de Investigação em Tecnologias e Serviços de Saúde, Portugal
Universidade do Porto Faculdade de Medicina, Portugal
2022/03/01 - 2022/03/31 Estagiário de Investigação (Investigação) Universidade de Aveiro Instituto de Biomedicina, Portugal
Universidade de Aveiro Instituto de Biomedicina, Portugal
2021/04/01 - 2021/07/05 Estagiário de Investigação (Investigação) Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal

Outros

Categoria Profissional
Instituição de acolhimento
Empregador
2020/06/01 - 2020/08/17 Extracurricular Internship Quinta and Vineyard Bottlers Vinhos S.A, Portugal
Produções

Publicações

Artigo em revista
  1. Tânia Lourenço; Lara Marques; Eduarda Ribeiro; Nuno Vale. "Enhancing Prostate and Bladder Cancer Treatment: Exploring the Synergistic Potential of Entecavir and 5-Fluorouracil Combinations". BioMed (2024): https://doi.org/10.3390/biomed4020015.
    10.3390/biomed4020015
  2. Lara Marques; Bárbara Costa; Mariana Pereira; Abigail Silva; Joana Santos; Leonor Saldanha; Isabel Silva; et al. "Advancing Precision Medicine: A Review of Innovative In Silico Approaches for Drug Development, Clinical Pharmacology and Personalized Healthcare". Pharmaceutics (2024): https://doi.org/10.3390/pharmaceutics16030332.
    10.3390/pharmaceutics16030332
  3. Ana Salomé Correia; Lara Marques; Armando Cardoso; Nuno Vale. "Exploring the Role of Drug Repurposing in Bridging the Hypoxia–Depression Connection". Membranes (2023): https://doi.org/10.3390/membranes13090800.
    10.3390/membranes13090800
  4. Lara Marques; Nuno Vale. "Prediction of CYP-Mediated Drug Interaction Using Physiologically Based Pharmacokinetic Modeling: A Case Study of Salbutamol and Fluvoxamine". Pharmaceutics (2023): https://doi.org/10.3390/pharmaceutics15061586.
    10.3390/pharmaceutics15061586
  5. Ana Salomé Correia; Lara Marques; Nuno Vale. "The Involvement of Hypoxia in the Response of Neuroblastoma Cells to the Exposure of Atorvastatin". Current Issues in Molecular Biology (2023): https://doi.org/10.3390/cimb45040218.
    10.3390/cimb45040218
  6. Lara Marques; Nuno Vale. "Unraveling the Impact of Salbutamol Polytherapy: Clinically Relevant Drug Interactions". Future Pharmacology (2023): https://doi.org/10.3390/futurepharmacol3010019.
    10.3390/futurepharmacol3010019
  7. Gonçalo de Jesus; Lara Marques; Nuno Vale; Rui Amaral Mendes. "The Effects of Chitosan on the Healing Process of Oral Mucosa: An Observational Cohort Feasibility Split-Mouth Study". Nanomaterials (2023): https://doi.org/10.3390/nano13040706.
    10.3390/nano13040706
  8. Nuno Vale; Mariana Pereira; Joana Santos; Catarina Moura; Lara Marques; Diana Duarte. "Prediction of Drug Synergism between Peptides and Antineoplastic Drugs Paclitaxel, 5-Fluorouracil, and Doxorubicin Using In Silico Approaches". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms24010069.
    10.3390/ijms24010069
  9. Lara Marques; Nuno Vale. "Salbutamol in the Management of Asthma: A Review". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms232214207.
    10.3390/ijms232214207
  10. Rafaela Rodrigues; Lara Marques; Pedro Vieira-Baptista; Carlos Sousa; Nuno Vale. "Therapeutic Options for Chlamydia trachomatis Infection: Present and Future". Antibiotics (2022): https://doi.org/10.3390/antibiotics11111634.
    10.3390/antibiotics11111634
  11. Lara Filipa Marques; Bárbara Costa; Nuno Vale. "New Data for Nebivolol after In Silico PK Study: Focus on Young Patients and Dosage Regimen". Pharmaceutics (2022): https://www.mdpi.com/1999-4923/14/9/1911.
    10.3390/pharmaceutics14091911
Poster em conferência
  1. Marques, Lara; Vale, Nuno. "Toward Personalized Salbutamol Therapy: Validating Virtual PatientDerived Population Pharmacokinetic Model with Real-World Data". Trabalho apresentado em PAGE (Population Approach Group Europe), 2024.
  2. Marques, Lara; Vale, Nuno. "Population Pharmacokinetic Study Involving Different Salbutamol Formulations". Trabalho apresentado em IJUP, 2023.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2024/02/07 Prediction of CYP-Mediated Drug Interaction Using Physiologically Based Pharmacokinetic Modeling: A Case Study of Salbutamol and Fluvoxamine 54th Meeting of the Portuguese Pharmacology Society
NOVA Medical School (Lisboa, Portugal)

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação)
Instituição / Organização
2022/11/30 - 2022/11/30 As a member of the organizing committee of ''Fórum Medicina de Precisão em Oncologia'', I was responsible for contacting sponsors for the event, managing the list of participants, preparing the materials needed for the event, and welcoming the participants and speakers on the day of the event. (2022/11/30 - 2022/11/30)
Encontro (Membro da Comissão Organizadora)
Universidade do Porto Faculdade de Medicina, Portugal
2020/09 - 2020/12 Organization of the scientific event ''LoginBiotech'', which addressed some ethical implications, computational neuroscience, and ocean bioremediation. I was part of the organizing committee, particularly the digital marketing team. (2020/12/18 - 2020/12/18)
Conferência (Membro da Comissão Organizadora)
Instituto Politecnico do Porto Escola Superior de Tecnologia da Saúde do Porto, Portugal

Participação em evento

Descrição da atividade
Tipo de evento
Nome do evento
Instituição / Organização
2024/04/11 - 2024/04/12 FMUP staff at the ''Saúde Digital e Inovação Biomédica'' and ''RISE'' stands at the Mostra da Universidade do Porto (Mostra UP), an annual event to showcase UP courses to primary/secondary school students.
Exposição
Mostra da Universidade do Porto 2024
Universidade do Porto, Portugal
2024/04/05 - 2024/04/05 Free and online event focused on population modeling for model-informed drug development (MIDD) and simulations of clinical trials using the MonolixSuite. Deepening knowledge of how to use the software and new potentialities.
Oficina (workshop)
Pharmacometrics Spring School 2024: Modeling and Simulations with MonolixSuite™
Simulations Plus Inc, Estados Unidos
2023/04/21 - 2023/04/22 FMUP staff at the ''RISE/CINTESIS'' stand at the Mostra da Universidade do Porto (Mostra UP), an annual event to showcase UP courses to primary/secondary school students.
Exposição
Mostra da Universidade do Porto 2023
Universidade do Porto, Portugal
2022/03 - 2022/03 Event with seminars by guest speakers and presentations of scientific research projects developed at the University of Aveiro with a focus on Medicine based on prevention, prediction, personalization and participation.
Conferência
MEDISIS Open Day 2022
Universidade de Aveiro Instituto de Biomedicina, Portugal
2021/10 - 2021/10 ''Think Big in Biotechnology'', under the theme «Fostering SMART Innovation Synergies» brings together several guests to discuss new ways of facing the challenges in the post-pandemic world.
Conferência
3º Fórum de Inovação em Biotecnologia
Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
2020/10 - 2020/10 An event that brought together several names from the academic and business worlds, addressing the growing importance of biotechnology in our daily lives.
Conferência
2º Fórum de Inovação em Biotecnologia
Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
2019/12 - 2019/12 Scientific event organized by students from the Medicinal Biotechnology degree course to promote this area, covering all its potential applications. The event featured two panels: Biomaterials and Regenerative Medicine.
Conferência
Biotech In Vivo
Instituto Politecnico do Porto Escola Superior de Tecnologia da Saúde do Porto, Portugal
2018/12 - 2018/12 Scientific event organized by students from the Medicinal Biotechnology degree course to disseminate this area, addressing the development of emerging therapeutic systems such as gene therapy, cell therapy, regenerative medicine and personalized medicine.
Conferência
BMeeting
Instituto Politecnico do Porto Escola Superior de Tecnologia da Saúde do Porto, Portugal

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2023 - Atual Mathematical Biosciences and Engineering (1551-0018) AIMS Press

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2024/04/03 - 2024/04/03 FMUP staff at the FMUP Open Day. Workshop on Digital Health to promote the ''Saúde Digital e Inovação Biomédica'' degree. FMUP Open Day (Ensino secundário) Universidade do Porto Faculdade de Medicina, Portugal
2024/02/09 - 2024/02/09 Escola de Inverno da Faculdade de Medicina da Universidade do Porto Therapeutic Drug Monitoring for Personalized Medicine (Outros) Universidade do Porto Faculdade de Medicina, Portugal
2023/07/11 - 2023/07/11 Escola de Verão da Faculdade de Medicina da Universidade do Porto Farmacometria no Apoio à Medicina Personalizada (Outros) Universidade do Porto Faculdade de Medicina, Portugal
Distinções

Prémio

2021 Final Phase - Amyris Innovation BIG Impact Award
Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal