Identificação pessoal

Nome completo

CLÉVIO DAVID RODRIGUES NÓBREGA

Nomes de citação

• Nóbrega, Clévio David Rodrigues

Identificadores de autor

Ciência ID

C510-7F41-BAF8

ORCID iD

0000-0002-8312-5292

Endereços de correio eletrónico

• cdnobrega@ualg.pt (Profissional)

Domínios de atuação

• Ciências Médicas e da Saúde - Medicina Básica - Neurociências
• Ciências Médicas e da Saúde - Biotecnologia Médica - Diagnóstico e Terapias de Base Genética
• Ciências Médicas e da Saúde - Biotecnologia Médica - Tecnologias que envolvem a Manipulação de Células,Tecidos,Órgãos ou todo o Organismo

	Grau	Classificação
2022 Concluído	Ciências Biomédicas (Título de Agregado) Universidade do Algarve, Portugal	Aprovado
2002 - 2007 Concluído	Biologia Molecular e Citogenética (Doutoramento) Universidade da Madeira, Portugal "A multilocus comparative study of nucleotide variation in Drosophila madeirensis and the close relative D. subobscura: Insights into the speciation process of D. madeirensis" (TESE/DISSERTAÇÃO)	aprovado distinção e louvor
1995 - 2000 Concluído	Biologia, Ramo Científico (Licenciatura) Universidade da Madeira, Portugal "Análise genética do isolamento reprodutor entre D. subobscura e D. madeirensis. Estudo de 3 genes: yellow, antennae color e RNA polimerase II do cromossoma X" (TESE/DISSERTAÇÃO)	15

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2021 - Atual	Investigador principal (carreira) (Investigação)	Universidade do Algarve, Portugal
	Algarve Biomedical Center Research Institute (ABC-Ri), Portugal
2016 - 2020	Investigador principal (carreira) (Investigação)	Universidade do Algarve, Portugal
	Centro de Investigação em Bioomedicina, Portugal
2007/10 - 2016/08	Pós-doutorado (Investigação)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2007/01 - 2007/10	Pós-doutorado (Investigação)	Universitat de Barcelona, Espanha

Docência no Ensino Superior

	Categoria Profissional Instituição de acolhimento	Empregador
2024/12/17 - Atual	Professor Associado (Docente Universitário)	Universidade do Algarve, Portugal
2016/09 - 2024/12/16	Professor Auxiliar (Docente Universitário)	Universidade do Algarve, Portugal
2015/09 - 2016/08	Professor Auxiliar Convidado (Docente Universitário)	Universidade do Algarve, Portugal

Cargos e Funções

	Categoria Profissional Instituição de acolhimento	Empregador
2024 - Atual	Vice-Presidente	Centro Académico de Investigação e Formação Biomédica do Algarve, Portugal
	Centro Académico de Investigação e Formação Biomédica do Algarve, Portugal
2022/10 - Atual	Executive Board Director	Laboratório Colaborativo do Algarve Biomedical Center: soluções integradas para o envelhecimento e rejuvenescimento (ABC-CoLAB), Portugal
	Laboratório Colaborativo do Algarve Biomedical Center: soluções integradas para o envelhecimento e rejuvenescimento (ABC-CoLAB), Portugal
2021/06 - Atual	Presidente do Conselho Pedagógico	Universidade do Algarve, Portugal
	Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2021 - Atual	Director	Universidade do Algarve, Portugal
	Algarve Biomedical Center Research Institute (ABC-Ri), Portugal
2016 - Atual	Conselho científico	Universidade do Algarve, Portugal
	Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2018/12 - 2020/12/31	Director	Universidade do Algarve, Portugal
	Universidade do Algarve Centro de Investigação em Biomedicina, Portugal

Bolsa

	Designação	Financiadores
2024/09/01 - Atual	AgeT ech - Investigação de Novos Compostos para o Desenvolvimento Inovador de Produtos Cosméticos de AntiEnvelhecimento AgeTech Investigador responsável Universidade do Algarve, Portugal	Em curso

Projeto

	Designação	Financiadores
2023/03/01 - Atual	AdvGT-CSB: Advancing the development of a gene therapy for Cockayne Syndrome type B #457 AdvGT-CSB Investigador responsável Algarve Biomedical Center Research Institute (ABC-Ri), Portugal	Viljem Julijan Association for Children with Rare Diseases Em curso
2022/06/01 - Atual	CureCSB - Development of a Gene-Replacement Therapy for Cockayne Syndrome Type B #438 CureCSB Investigador responsável Algarve Biomedical Center Research Institute (ABC-Ri), Portugal	Em curso
2021/04/01 - Atual	ALgarve Fit Ageing Score: uma nova ferramenta integrada para melhorar a qualidade de vida e o envelhecimento saudável 072586 Investigador	Comissão de Coordenação e Desenvolvimento Regional do Algarve Em curso
2021/01/01 - Atual	Investigação de terapias experimentais em estudos pré-clínicos para o Síndroma de Cockayne 431#ABC-RI) Investigador responsável	Em curso
2019/03/01 - Atual	Overexpression of the RNA-binding protein X as a therapeutic strategy to Machado-Joseph disease and other Polyglutamine diseases. #22424 Investigador responsável	The French Muscular Dystrophy Association (AFM) Concluído
2018/10/01 - Atual	The role of stress granules in Polyglutamine disease: from pathogenesis to molecular therapy "PTDC/MED-NEU/29480/2017 ALG-01-0145-FEDER-29480 ""SeGrPolyQ""" Investigador responsável	Fundação para a Ciência e a Tecnologia, I.P. Concluído
2018/01/01 - 2021/12/31	Using an OMICS approach to found new genetic profiles associated with obesity NA Investigador	Instituto de Salud Carlos III Concluído
2020/05/11 - 2020/08/11	Development of a new assay do detect SARS-CoV-2 directly from clinical samples 126_596760136 Investigador responsável Universidade do Algarve Centro de Investigação em Biomedicina, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2018/02 - 2020/01	Neuroprotective therapeutic approach for Spinocerebellar Ataxia type 2: pharmacological targeting of AMPK ZUNIALGA Investigador responsável	Ataxia UK Concluído
2017/01/01 - 2017/12/31	Integración de varias omicas para el estudio de la obesidad NA Investigador	Fundación Investigación Hospital General Universitario de Valencia
2015/03 - 2017/03	Ataxin-2 as a new molecular target in Machado-Joseph disease: from translation regulation to disease alleviation 18876 Investigador responsável	The French Muscular Dystrophy Association (AFM) Concluído
2014/01/01 - 2015/12/31	The role of ataxin-2 in Machado-Joseph disease: a molecular therapy approach with viral vectors. NA Investigador responsável	National Ataxia Foundation Concluído
2013/03 - 2015/02	Exploring miRNA contribution to amyloid-b-metabolism: development of a novel lentiviral platform for multiple miRNA expression in Alzheimer´s disease Provided by PTCRIS: 125208 125208 Investigador	Fundação para a Ciência e a Tecnologia, I.P. Concluído
2013/03 - 2014/04	Silencing Machado-Joseph Disease through the systemic route 125367 Provided by PTCRIS: 125367 Investigador	Fundação para a Ciência e a Tecnologia, I.P. Concluído
2010/02 - 2013/04	The role of calpain-mediated proteolysis of ataxin-3 in Machado-Joseph disease: a molecular therapy approach with viral vectors Provided by PTCRIS: 70384 70384 99307 Provided by PTCRIS: 99307 Investigador	Fundação para a Ciência e a Tecnologia, I.P. Concluído
2010/01/01 - 2011/12/31	Role of the autophagy-related protein Beclin-1 in Machado-Joseph disease NA Investigador	The French Muscular Dystrophy Association (AFM) Concluído
2010/01/01 - 2010/12/31	Modulation of autophagy as a novel therapeutic strategy for Machado-Joseph disease. NA Investigador	National Ataxia Foundation

Publicações

Artigo em revista	Nádia Silva; Ana Teresa Rajado; Filipa Esteves; David Brito; Joana Apolónio; Vânia Palma Roberto; Alexandra Binnie; et al. "Measuring healthy ageing: current and future tools". Biogerontology (2023): https://doi.org/10.1007/s10522-023-10041-2. 10.1007/s10522-023-10041-2 Tiago Moreira-Gomes; Clévio Nóbrega. "From the disruption of RNA metabolism to the targeting of RNA-binding proteins: The case of polyglutamine spinocerebellar ataxias". Journal of Neurochemistry (2023): https://doi.org/10.1111/jnc.16010. 10.1111/jnc.16010 Moreira-Gomes, Tiago; Nóbrega, Clévio. "From the disruption of RNA metabolism to the targeting of RNA-binding proteins: The case of polyglutamine spinocerebellar ataxias". Journal of Neurochemistry (2023): http://dx.doi.org/10.1111/jnc.16010. 10.1111/jnc.16010 Brito, D. V. C.; Esteves, F.; Rajado, A. T.; Silva, N.; Andrade, R.; Apolónio, J.; Calado, S.; et al. "Assessing cognitive decline in the aging brain: lessons from rodent and human studies". npj Aging 9 1 (2023): http://dx.doi.org/10.1038/s41514-023-00120-6. 10.1038/s41514-023-00120-6 Esteves, Filipa; Brito, David; Rajado, Ana Teresa; Silva, Nádia; Apolónio, Joana; Roberto, Vânia Palma; Araújo, Inês; et al. "Reprogramming iPSCs to study age-related diseases: Models, therapeutics, and clinical trials". Mechanisms of Ageing and Development 214 (2023): 111854. http://dx.doi.org/10.1016/j.mad.2023.111854. 10.1016/j.mad.2023.111854 Rodrigo Paulino; Clévio Nóbrega. "Autophagy in Spinocerebellar Ataxia Type 3: From Pathogenesis to Therapeutics". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24087405. 10.3390/ijms24087405 Elena Grao-Cruces; Carmen M. Claro-Cala; Sergio Montserrat-de la Paz; Clevio Nobrega. "Lipoprotein Metabolism, Protein Aggregation, and Alzheimer’s Disease: A Literature Review". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24032944. 10.3390/ijms24032944 Carmo-Silva, Sara; Ferreira-Marques, Marisa; Nóbrega, Clévio; Botelho, Mariana; Costa, Daniela; Aveleira, Célia A; Pulst, Stefan M; Pereira de Almeida, Luís; Cavadas, Claudia. "Ataxin-2 in the hypothalamus at the crossroads between metabolism and clock genes". Journal of Molecular Endocrinology 70 1 (2023): http://dx.doi.org/10.1530/jme-21-0272. 10.1530/jme-21-0272 Estevam, Bernardo; Matos, Carlos A; Nóbrega, Clévio; Bernardo Estevam; Carlos A Matos; Clévio Nóbrega. "PolyQ Database—an integrated database on polyglutamine diseases". Database 2023 (2023): http://dx.doi.org/10.1093/database/baad060. 10.1093/database/baad060 Adriana Marcelo; Carlos A. Matos; Clévio Nóbrega. "Autophagy is dysregulated in spinocerebellar ataxia type 2". Autophagy Reports (2022): https://doi.org/10.1080/27694127.2022.2065603. 10.1080/27694127.2022.2065603 Koppenol, Rebekah; Conceição, André; Afonso, Inês T; Afonso-Reis, Ricardo; Costa, Rafael G; Tomé, Sandra; Teixeira, Diogo; et al. "The stress granule protein G3BP1 alleviates spinocerebellar ataxia-associated deficits". Brain (2022): http://dx.doi.org/10.1093/brain/awac473. 10.1093/brain/awac473 Inês T. Afonso; Patrícia Lima; André Conceição; Carlos A. Matos; Clévio Nóbrega. "Mutant Ataxin-2 Expression in Aged Animals Aggravates Neuropathological Features Associated with Spinocerebellar Ataxia Type 2". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms231911896. 10.3390/ijms231911896 Vasconcelos-Ferreira, Ana; Martins, Inês Morgado; Lobo, Diana; Pereira, Dina; Lopes, Miguel M.; Faro, Rosário; Lopes, Sara M.; et al. "ULK overexpression mitigates motor deficits and neuropathology in mouse models of Machado-Joseph disease". Molecular Therapy 30 1 (2022): 370-387. http://dx.doi.org/10.1016/j.ymthe.2021.07.012. 10.1016/j.ymthe.2021.07.012 Marcelo, Adriana; Afonso, Inês T.; Afonso-Reis, Ricardo; Brito, David V. C.; Costa, Rafael G.; Rosa, Ana; Alves-Cruzeiro, João; et al. "Autophagy in Spinocerebellar ataxia type 2, a dysregulated pathway, and a target for therapy". Cell Death & Disease 12 12 (2021): http://dx.doi.org/10.1038/s41419-021-04404-1. 10.1038/s41419-021-04404-1 Vasconcelos-Ferreira, Ana; Carmo-Silva, Sara; Codêsso, José Miguel; Silva, Patrick; Martinez, Alberto Rolim Muro; França Jr, Marcondes Cavalcante; Nóbrega, Clévio; Pereira de Almeida, Luís. "The autophagy-enhancing drug carbamazepine improves neuropathology and motor impairment in mouse models of Machado–Joseph disease". Neuropathology and Applied Neurobiology 48 1 (2021): http://dx.doi.org/10.1111/nan.12763. 10.1111/nan.12763 Marcelo, Adriana; Koppenol, Rebekah; de Almeida, Luís Pereira; Matos, Carlos A.; Nóbrega, Clévio. "Stress granules, RNA-binding proteins and polyglutamine diseases: too much aggregation?". Cell Death & Disease 12 6 (2021): http://dx.doi.org/10.1038/s41419-021-03873-8. 10.1038/s41419-021-03873-8 Afonso-Reis, Ricardo; Afonso, Inês T.; Nóbrega, Clévio. "Current Status of Gene Therapy Research in Polyglutamine Spinocerebellar Ataxias". International Journal of Molecular Sciences 22 8 (2021): 4249. http://dx.doi.org/10.3390/ijms22084249. 10.3390/ijms22084249 Nóbrega, Clévio David Rodrigues. "Mapping gene expression in social anxiety reveals the main brain structures involved in this disorder". Brain Behavioural Research 394 (2021): Publicado Nóbrega, Clévio David Rodrigues. "Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)". Autophagy (2021): Publicado Nóbrega, Clévio; Conceição, André; Costa, Rafael G.; Koppenol, Rebekah; Sequeira, Raquel L.; Nunes, Ricardo; Carmo-Silva, Sara; et al. "The cholesterol 24-hydroxylase activates autophagy and decreases mutant huntingtin build-up in a neuroblastoma culture model of Huntington’s disease". BMC Research Notes 13 1 (2020): http://dx.doi.org/10.1186/s13104-020-05053-x. 10.1186/s13104-020-05053-x Santana, Magda M.; Paixão, Susana; Cunha-Santos, Janete; Silva, Teresa Pereira; Trevino-Garcia, Allyson; Gaspar, Laetitia S.; Nóbrega, Clévio; et al. "Trehalose alleviates the phenotype of Machado–Joseph disease mouse models". Journal of Translational Medicine 18 1 (2020): http://dx.doi.org/10.1186/s12967-020-02302-2. 10.1186/s12967-020-02302-2 Nóbrega, Clévio David Rodrigues. "Lauroylated Histidine-Enriched S4 13-PV Peptide as an Efficient Gene Silencing Mediator in Cancer Cells". Pharmaceutical Research 37 (2020): Publicado Catarina Nunes; Isa Mestre; Adriana Marcelo; Rebekah Koppenol; Carlos A Matos; Clévio Nóbrega. "MSGP: the first database of the protein components of the mammalian stress granules". Database (2019): https://doi.org/10.1093/database/baz031. 10.1093/database/baz031 Adriana Marcelo; Filipa Brito; Sara Carmo-Silva; Carlos A Matos; João Alves-Cruzeiro; Ana Vasconcelos-Ferreira; Rebekah Koppenol; et al. "Cordycepin activates autophagy through AMPK phosphorylation to reduce abnormalities in Machado–Joseph disease models". Human Molecular Genetics (2019): https://doi.org/10.1093/hmg/ddy328. 10.1093/hmg/ddy328 Nóbrega, C.; Mendonça, L.; Marcelo, A.; Lamazière, A.; Tomé, S.; Despres, G.; Matos, C.A.; et al. "Restoring brain cholesterol turnover improves autophagy and has therapeutic potential in mouse models of spinocerebellar ataxia". Acta Neuropathologica 138 5 (2019): 837-858. http://www.scopus.com/inward/record.url?eid=2-s2.0-85067663327&partnerID=MN8TOARS. 10.1007/s00401-019-02019-7 Mendonça, L.S.; Nóbrega, C.; Tavino, S.; Brinkhaus, M.; Matos, C.; Tomé, S.; Moreira, R.; et al. "Ibuprofen enhances synaptic function and neural progenitors proliferation markers and improves neuropathology and motor coordination in Machado-Joseph disease models". Human molecular genetics 28 22 (2019): 3691-3703. http://www.scopus.com/inward/record.url?eid=2-s2.0-85077346304&partnerID=MN8TOARS. 10.1093/hmg/ddz097 Nóbrega, C.; Codêsso, J.M.; Mendonça, L.; Pereira De Almeida, L.. "RNA Interference Therapy for Machado-Joseph Disease: Long-Term Safety Profile of Lentiviral Vectors Encoding Short Hairpin RNAs Targeting Mutant Ataxin-3". Human Gene Therapy 30 7 (2019): 841-854. http://www.scopus.com/inward/record.url?eid=2-s2.0-85069664080&partnerID=MN8TOARS. 10.1089/hum.2018.157 Matos, Carlos A.; de Almeida, Luís Pereira; Nóbrega, Clévio. "Machado-Joseph disease/spinocerebellar ataxia type 3: lessons from disease pathogenesis and clues into therapy". Journal of Neurochemistry 148 1 (2018): 8-28. http://dx.doi.org/10.1111/jnc.14541. 10.1111/jnc.14541 Nóbrega, Clévio; Alves, Sandro. "Editorial: Gene Silencing and Editing Strategies for Neurodegenerative Diseases". Frontiers in Neuroscience 12 (2018): http://dx.doi.org/10.3389/fnins.2018.00425. 10.3389/fnins.2018.00425 Oliveira Miranda, C.; Marcelo, A.; Silva, T.P.; Barata, J.; Vasconcelos-Ferreira, A.; Pereira, D.; Nóbrega, C.; et al. "Repeated Mesenchymal Stromal Cell Treatment Sustainably Alleviates Machado-Joseph Disease". Molecular Therapy 26 9 (2018): 2131-2151. http://www.scopus.com/inward/record.url?eid=2-s2.0-85050950218&partnerID=MN8TOARS. 10.1016/j.ymthe.2018.07.007 Mendonça, L.S.; Onofre, I.; Miranda, C.O.; Perfeito, R.; Nóbrega, C.; de Almeida, L.P.. "Stem Cell-Based Therapies for Polyglutamine Diseases". 1049 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85041956170&partnerID=MN8TOARS. 10.1007/978-3-319-71779-1_21 Nóbrega, C.; Simões, A.T.; Duarte-Neves, J.; Duarte, S.; Vasconcelos-Ferreira, A.; Cunha-Santos, J.; Pereira, D.; et al. "Molecular Mechanisms and Cellular Pathways Implicated in Machado-Joseph Disease Pathogenesis". 1049 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85041952619&partnerID=MN8TOARS. 10.1007/978-3-319-71779-1_18 Matos, C.A.; Carmona, V.; Vijayakumar, U.-G.; Lopes, S.; Albuquerque, P.; Conceição, M.; Nobre, R.J.; Nóbrega, C.; de Almeida, L.P.. "Gene therapies for polyglutamine diseases". 1049 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85041963917&partnerID=MN8TOARS. 10.1007/978-3-319-71779-1_20 Carmo-Silva, S.; Nobrega, C.; Pereira de Almeida, L.; Cavadas, C.. "Unraveling the Role of Ataxin-2 in Metabolism". Trends in Endocrinology and Metabolism 28 4 (2017): 309-318. http://www.scopus.com/inward/record.url?eid=2-s2.0-85009726744&partnerID=MN8TOARS. 10.1016/j.tem.2016.12.006 Albuquerque, D.; Nóbrega, C.; Manco, L.; Padez, C.. "The contribution of genetics and environment to obesity". British Medical Bulletin 123 1 (2017): 159-173. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029678152&partnerID=MN8TOARS. 10.1093/bmb/ldx022 Matos, C.A.; de Almeida, L.P.; Nóbrega, C.. "Proteolytic cleavage of polyglutamine disease-causing proteins: Revisiting the toxic fragment hypothesis". Current Pharmaceutical Design 23 5 (2017): 753-775. http://www.scopus.com/inward/record.url?eid=2-s2.0-85017122161&partnerID=MN8TOARS. 10.2174/1381612822666161227121912 Alves-Cruzeiro, João M. Da Conceição; Mendonça, Liliana; Pereira de Almeida, Luís; Nóbrega, Clévio. "Motor Dysfunctions and Neuropathology in Mouse Models of Spinocerebellar Ataxia Type 2: A Comprehensive Review". Frontiers in Neuroscience 10 (2016): http://dx.doi.org/10.3389/fnins.2016.00572. 10.3389/fnins.2016.00572 Conceição, M.; Mendonça, L.; Nóbrega, C.; Gomes, C.; Costa, P.; Hirai, H.; Moreira, J.N.; et al. "Intravenous administration of brain-targeted stable nucleic acid lipid particles alleviates Machado-Joseph disease neurological phenotype". Biomaterials 82 (2016): 124-137. http://www.scopus.com/inward/record.url?eid=2-s2.0-84956644943&partnerID=MN8TOARS. 10.1016/j.biomaterials.2015.12.021 Conceição, M.; Mendonça, L.; Nóbrega, C.; Gomes, C.; Costa, P.; Hirai, H.; Moreira, J.N.; et al. "Safety profile of the intravenous administration of brain-targeted stable nucleic acid lipid particles". Data in Brief 6 (2016): 700-705. http://www.scopus.com/inward/record.url?eid=2-s2.0-84956617357&partnerID=MN8TOARS. 10.1016/j.dib.2016.01.017 Matos, C.A.; Nóbrega, C.; Louros, S.R.; Almeida, B.; Ferreiro, E.; Valero, J.; De Almeida, L.P.; Macedo-Ribeiro, S.; Carvalho, A.L.. "Ataxin-3 phosphorylation decreases neuronal defects in spinocerebellar ataxia type 3 models". Journal of Cell Biology 212 4 (2016): 465-480. http://www.scopus.com/inward/record.url?eid=2-s2.0-84959536774&partnerID=MN8TOARS. 10.1083/jcb.201506025 Aveleira CA; Botelho M; Carmo-Silva S; Pascoal JF; Ferreira-Marques M; Nóbrega C; Cortes L; et al. "Neuropeptide Y stimulates autophagy in hypothalamic neurons.". (2015): http://europepmc.org/abstract/med/25775546. 10.1073/pnas.1416609112 Albuquerque D; Stice E; Rodríguez-López R; Manco L; Nóbrega C; Albuquerque, David; Stice, Eric; et al. "Current review of genetics of human obesity: from molecular mechanisms to an evolutionary perspective.". (2015): http://europepmc.org/abstract/med/25749980. 10.1007/s00438-015-1015-9 Nóbrega, C.; Carmo-Silva, S.; Albuquerque, D.; Vasconcelos-Ferreira, A.; Vijayakumar, U.-G.; Mendonça, L.; Hirai, H.; Pereira De Almeida, L.. "Re-establishing ataxin-2 downregulates translation of mutant ataxin-3 and alleviates Machado-Joseph disease". Brain 138 12 (2015): 3537-3554. http://www.scopus.com/inward/record.url?eid=2-s2.0-84951031850&partnerID=MN8TOARS. 10.1093/brain/awv298 Albuquerque, David; Nóbrega, Clévio; Rodríguez-López, Raquel; Manco, Licínio. "Association study of common polymorphisms in MSRA, TFAP2B, MC4R, NRXN3, PPARGC1A, TMEM18, SEC16B, HOXB5 and OLFM4 genes with obesity-related traits among Portuguese children". Journal of Human Genetics 59 6 (2014): 307-313. http://dx.doi.org/10.1038/jhg.2014.23. 10.1038/jhg.2014.23 Albuquerque, David; Estévez, Manuela Núñez; Víbora, Pilar Beato; Giralt, Plácida Sánchez; Balsera, Aránzazu Margallo; Cortés, Pedro Gil; López, Mercedes Jiménez; et al. "Novel Variants in theMC4RandLEPRGenes among Severely Obese Children from the Iberian Population". Annals of Human Genetics 78 3 (2014): 195-207. http://dx.doi.org/10.1111/ahg.12058. Publicado • 10.1111/ahg.12058 Mendonca, L. S.; Nobrega, C.; Hirai, H.; Kaspar, B. K.; Pereira de Almeida, L.. "Transplantation of cerebellar neural stem cells improves motor coordination and neuropathology in Machado-Joseph disease mice". Brain n 19 Dec (2014): 1-9. Publicado • 10.1093/brain/awu352 Nobrega, Clevio; Nascimento-Ferreira, Isabel; Onofre, Isabel; Albuquerque, David; Deglon, Nicole; Pereira de Almeida, Luis. "RNA interference mitigates motor and neuropathological deficits in a cerebellar mouse model of machado-joseph disease.". PloS one 9 8 (2014): e100086-e100086. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:25144231&KeyUID=MEDLINE:25144231. 10.1371/journal.pone.0100086 Albuquerque, David; Nóbrega, Clévio; Manco, Licínio. "The lactase persistence -13910C>T polymorphism shows indication of association with abdominal obesity among Portuguese children". Acta Paediatrica 102 4 (2013): e153-e157. http://dx.doi.org/10.1111/apa.12134. 10.1111/apa.12134 Nascimento-Ferreira, I.; Nobrega, C.; Vasconcelos-Ferreira, A.; Onofre, I.; Albuquerque, D; Aveleira, C.; Hirai, H.; Deglon, N.; Pereira de Almeida, L.. "Beclin 1 mitigates motor and neuropathological deficits in genetic mouse models of Machado-Joseph disease". Brain 136 7 (2013): 2173-2188. Publicado • 10.1093/brain/awt144 Albuquerque, David; Nóbrega, Clévio; Manco, Licínio. "Association of FTO Polymorphisms with Obesity and Obesity-Related Outcomes in Portuguese Children". PLoS ONE 8 1 (2013): e54370-e54370. Publicado • 10.1371/journal.pone.0054370 Nóbrega, Clévio; Nascimento-Ferreira, Isabel; Onofre, Isabel; Albuquerque, David; Hirai, Hirokazu; Déglon, Nicole; de Almeida, Luís Pereira. "Silencing Mutant Ataxin-3 Rescues Motor Deficits and Neuropathology in Machado-Joseph Disease Transgenic Mice". PLoS ONE 8 1 (2013): e52396-e52396. Publicado • 10.1371/journal.pone.0052396 Monteiro, António; Nóbrega, Clévio; Abrantes, Isabel; Gomes, Celeste. "Diagnosing Portuguese Students' Misconceptions about the Mineral Concept". International Journal of Science Education 12 (2012): 1-22. Publicado • 10.1080/09500693.2012.731617 Costa, P. M.; Cardoso, A. L.; Nobrega, C.; Pereira de Almeida, L. F.; Bruce, J. N.; Canoll, P.; Pedroso de Lima, M. C.. "MicroRNA-21 silencing enhances the cytotoxic effect of the antiangiogenic drug sunitinib in glioblastoma". Human Molecular Genetics 22 5 (2012): 904-918. Publicado • 10.1093/hmg/dds496 Nóbrega, Clévio; Nascimento-Ferreira, Isabel; Onofre, Isabel; Albuquerque, David; Conceição, Mariana; Déglon, Nicole; Almeida, Luís Pereira. "Overexpression of Mutant Ataxin-3 in Mouse Cerebellum Induces Ataxia and Cerebellar Neuropathology". The Cerebellum . (2012): .-.. Publicado • 10.1007/s12311-012-0432-0 Albuquerque D; Nóbrega C; Samouda H; Manco L; Albuquerque, D; Nóbrega, Clévio David Rodrigues; Hanene Samouda; Manco, Licínio. "Assessment of obesity and abdominal obesity among Portuguese children.". Acta Medica Portuguesa 25 3 (2012): 169-173. http://europepmc.org/abstract/med/23069237. Publicado Albuquerque, D.; Nóbrega, C.; Samouda, H.; Manco, L.. "Assessment of obesity and abdominal obesity among Portuguese children,Avaliação da obesidade e obesidade abdominal em crianças Portuguesas". Acta Medica Portuguesa 25 3 (2012): 169-173. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866904803&partnerID=MN8TOARS. Sousa-Ferreira, Lígia; Garrido, Manuel; Nascimento-Ferreira, Isabel; Nobrega, Clévio; Santos-Carvalho, Ana; ¿?lvaro, Ana Rita; Rosmaninho-Salgado, Joana; et al. "Moderate Long-Term Modulation of Neuropeptide Y in Hypothalamic Arcuate Nucleus Induces Energy Balance Alterations in Adult Rats". PLoS ONE 6 7 (2011): 22333-22333. Publicado • 10.1371/journal.pone.0022333 Khadem, M.; Camacho, R.; Nobrega, C.; Nóbrega, Clévio David Rodrigues; Mahnaz Khadem; Roberto Camacho. "Studies of the species barrier between Drosophila subobscura and D-madeirensis V: the importance of sex-linked inversion in preserving species identity". Journal of Evolutionary Biology 24 6 (2011): 1263-1273. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000290313500011&KeyUID=WOS:000290313500011. Publicado • 10.1111/j.1420-9101.2011.02263.x Alves, S.; Nascimento-Ferreira, I.; Dufour, N.; Hassig, R.; Auregan, G.; Nobrega, C.; Brouillet, E.; et al. "Silencing ataxin-3 mitigates degeneration in a rat model of Machado-Joseph disease: no role for wild-type ataxin-3?". Human Molecular Genetics 19 12 (2010): 2380-2394. Publicado • 10.1093/hmg/ddq111 Nobrega, C.; Khadem, M; Aguade, M.; Segarra, C. "Genetic Exchange versus Genetic Differentiation in a Medium-Sized Inversion of Drosophila: The A2/Ast Arrangements of Drosophila subobscura". Molecular Biology and Evolution 25 8 (2008): 1534-1543. Publicado • 10.1093/molbev/msn100
Capítulo de livro	M. Codêsso, José; A. Matos, Carlos; Nóbrega, Clévio. "RNA Interference Applications for Machado-Joseph Disease". In RNA Therapeutics - History, Design, Manufacturing, and Applications [Working Title]. IntechOpen, 2022. 10.5772/intechopen.109261 Albuquerque, David; Carmo-Silva, Sara; Álvarez-Vaca, Daniel; Aveleira, Célia; Nóbrega, Clévio. "Role of Mitochondrial Dysfunction in Human Obesity". In Handbook of Mitochondrial Dysfunction, 379-388. CRC Press, 2019. 10.1201/9780429443336-30 Albuquerque, David; Manco, Licínio; Nóbrega, Clévio; Albuquerque, D.; Manco, L.; Nóbrega, C.. "Molecular Biology of Human Obesity: Non-epigenetics in Comparison with Epigenetic Processes". In Handbook of Nutrition, Diet, and Epigenetics, 1-18. Springer International Publishing, 2017. 10.1007/978-3-319-31143-2_7-1 Albuquerque, David; Manco, Licínio; Nóbrega, Clévio. "Genetics of Human Obesity". In Obesity, 87-106. Springer International Publishing, 2016. 10.1007/978-3-319-19821-7_7 Nóbrega, Clévio David Rodrigues. "Genetic contribution: Common forms of Obesity". In Molecular mechanisms underpinning the development of obesity, 37-56. US: Springer, 2015. Publicado Albuquerque, David; Manco, Licínio; Nóbrega, Clévio; Nóbrega, Clévio David Rodrigues. "Epigenetics of Human Obesity: A Link Between Genetics and Nutrition". In Molecular Mechanisms Underpinning the Development of Obesity, 101-127. US: Springer International Publishing, 2014. Publicado • 10.1007/978-3-319-12766-8_8 Nobrega, Clevio; de Almeida, L. P.. "Machado-Joseph Disease / Spinocerebellar Ataxia Type 3". In Spinocerebellar Ataxia, 103-138. Croatia: InTech, 2012. Publicado • 10.5772/28576
Edição de livro	Nóbrega, Clévio David Rodrigues. Polyglutamine Disorders. Springer International Publishing. 2018. 10.1007/978-3-319-71779-1 Nóbrega, Clévio David Rodrigues ; Sandro Alves. Gene Silencing and Editing Strategies for Neurodegenerative Diseases. Frontiers Media SA. 2018. 10.3389/978-2-88945-551-5 Nóbrega, Clévio David Rodrigues; Rodríguez-López, Raquel. Molecular mechanisms underpinning the development of obesity. US: Springer. 2015. Publicado
Livro	Nóbrega, Clévio David Rodrigues ; Liliana Mendonça; Carlos A Matos. A Handbook of Gene and Cell Therapy. Springer. 2020.
Poster em conferência	Nóbrega, Clévio David Rodrigues. "Silencing of CypX gene in the hypothalamus and its impact on whole-body metabolism". Trabalho apresentado em International Meeting of the Portuguese Society of Genetics, 2020. Nóbrega, Clévio David Rodrigues. "A lentiviral genetic mouse model for spinocerebellar ataxia type 2". Trabalho apresentado em International Meeting of the Portuguese Society of Genetics, 2020. Nóbrega, Clévio David Rodrigues. "RBP-X modulates progerin levels and ameliorates its associated abnormalities in cellular models of HGPS". Trabalho apresentado em International Meeting of the Portuguese Society of Genetics, 2020. Nóbrega, Clévio David Rodrigues. "Mitigating the Progeroid Phenotype: A Gene Delivery Strategy to Improve Progerin-Associated Abnormalities". Trabalho apresentado em 24ª Reunião Anual da Sociedade Portuguesa de Genética Humana, 2020. Nóbrega, Clévio David Rodrigues. "Striatal neuropathology in spinocerebellar ataxia type 2: a new lentiviral mouse model". Trabalho apresentado em FENS 2020 Virtual Forum, 2020. Nóbrega, Clévio David Rodrigues. "An RNA binding protein alleviates pathology in two different mouse models of polyglutamine diseases.". Trabalho apresentado em 24ª Reunião Anual da Sociedade Portuguesa de Genética Humana, 2020. Nóbrega, Clévio David Rodrigues. "Autophagy Impairment in Spinocerebellar Ataxia Type 2: First Evidences and a Potential Therapeutic Strategy". Trabalho apresentado em 24ª Reunião Anual da Sociedade Portuguesa de Genética Humana, 2020. Nóbrega, Clévio David Rodrigues. "Silencing ATXN2 expression using CRISPR/Cas9". Trabalho apresentado em 24ª Reunião Anual da Sociedade Portuguesa de Genética Humana, 2020. Nóbrega, Clévio David Rodrigues. "CRISPR-Cas9 systems targeting ATXN3 as therapeutic approaches for Machado-Joseph Disease". Trabalho apresentado em MJD International Research Conference, 2019. Nóbrega, Clévio David Rodrigues. "CYP46A1-Gene therapy alleviates Machado-Joseph disease". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience, 2019. Nóbrega, Clévio David Rodrigues. "On the role of stress granules in autophagy". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience, 2019. Nóbrega, Clévio David Rodrigues. "RNA-binding proteins: new molecular targets for Polyglutamine diseases?". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience, 2019. Nóbrega, Clévio David Rodrigues. "Reinstating levels of dysregulated autophagy-associated transcripts alleviates neuropathology and motor impairments of mouse models of Machado-Joseph disease". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience, 2019. Nóbrega, Clévio David Rodrigues. "Resetting the clock on obesity: The tale of Hypothalamic Ataxin-2". Trabalho apresentado em Gordon Conference on Clocks in Model Organisms: Circadian Networks, Physiology and Health, 2019. Nóbrega, Clévio David Rodrigues. "Estudo do papel de uma proteína de ligação ao RNA na expressão de lamina e progerina". Trabalho apresentado em 5th MEEting of UAlg Medicine Students, 2019. Nóbrega, Clévio David Rodrigues. "Repeated treatment with mesenchymal stromal cells sustainably alleviates Machado-Joseph Disease and Its Efficacy Can Be Monitored With Neurospectroscopic Biomarkers". Trabalho apresentado em 1st international symposium Secretome With]Out[ Borders, 2018. Nóbrega, Clévio David Rodrigues. "Hypothalamic ataxin-2 at the crossroads of metabolism and circadian rhythm". Trabalho apresentado em Chrononutrition: From Epidemiology to Molecular Mechanism Symposium, London, 2018. Nóbrega, Clévio David Rodrigues. "Repeated mesenchymal stromal cells treatment sustainably alleviates Machado-Joseph Disease/Spinocerebellar ataxia type-3". Trabalho apresentado em European Society of Gene and Cell Therapy congress, 2018. Kumar, Sajal; Zhong, Hua; Sharma, Ruby; Li, Yiyi; Song, Mingzhou. "RNA-binding proteins in Polyglutamine diseases: from pathogenesis to molecular therapy". Trabalho apresentado em 11th Forum of Neuroscience (FENS), 2018. 10.1109/bibm.2018.8621502 Nóbrega, Clévio David Rodrigues. "Hypothalamic ataxin-2 a novel regulator of circadian rhythm". Trabalho apresentado em EMBO|EMBL Symposium: Biological Oscillators: Design, Mechanism, Function, 2018. Nóbrega, Clévio David Rodrigues. "Estudo do papel da autofagia na dispersão dos grânulos de stress". Trabalho apresentado em 4th MEEting of UAlg Medicine Students, 2018. Nóbrega, Clévio David Rodrigues. "Repeated treatment with mesenchymal stromal cells sustainably alleviates Machado-Joseph Disease/Spinocerebellar ataxia type-3 through neuroprotection of GABAergic neurons". Trabalho apresentado em 10th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC), 2017. Nóbrega, Clévio David Rodrigues. "TALEN and CRISPR gene-editing for treatment of Machado-Joseph disease". Trabalho apresentado em 2nd International Ataxia Research Conference (IARC), 2017. Nóbrega, Clévio David Rodrigues. "Ibuprofen improves neuropathology and increases neural progenitors proliferation, synaptic function and neurite growth in Machado-Joseph disease". Trabalho apresentado em 2nd International Ataxia Research Conference (IARC), 2017. Nóbrega, Clévio David Rodrigues. "Evaluation of proinflammatory cytokines expression in cells infected with coxsakievirus". Trabalho apresentado em XXVIII Congresso Brasileiro de Virologia, 2017. Nóbrega, Clévio David Rodrigues. "Repeated systemic injection of mesenchymal stem cells sustainably alleviates motor impairments and mitigates neuropathology in Machado-Joseph disease". Trabalho apresentado em XV Meeting of the Portuguese Society for Neurosciences, 2017. Nóbrega, Clévio David Rodrigues. "Hypothalamic ataxin-2: a new player in central regulation of energy balance". Trabalho apresentado em EMBO Workshop – Neural control of metabolism and eating behaviour, 2016. Nóbrega, Clévio David Rodrigues. "Ataxin-2 in the hypothalamus: a novel regulator of energy balance and metabolism". Trabalho apresentado em XIII CNC Annual Meeting, 2015. Nóbrega, Clévio David Rodrigues. "Transplantation of mesenchymal stem cells alleviates motor impairments and neuropathology in mouse models of Machado-Joseph disease". Trabalho apresentado em 9th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC), 2015. Nóbrega, Clévio David Rodrigues. "Neuropeptide Y1 and Y5 receptors activation stimulate autophagic flux in mouse hypothalamic neurons". Trabalho apresentado em 11th NPY-PYY-PP International Meeting, 2015. Nóbrega, Clévio David Rodrigues. "Impact of hypothalamic ataxin-2 on energy balance and metabolic profile". Trabalho apresentado em 9th World Congress of the International Brain Research Organization (IBRO, 2015. Nóbrega, Clévio David Rodrigues. "Neuropeptide Y rescues the aging phenotype of a mouse model of human premature aging". Trabalho apresentado em The Translational Science of Aging: From Functional Pathways to Interventions Gordon Research Conference on Biology of Aging, 2015. Nóbrega, Clévio David Rodrigues. "Transplantation of mesenchymal stem cells alleviates motor impairments and neuropathology of a mouse model of Machado-Joseph disease". Trabalho apresentado em International Society for Stem Cell Research (ISSCR) 2015 annual meeting, 2015. Nóbrega, Clévio David Rodrigues. "Gene editing strategies towards Machado Joseph disease". Trabalho apresentado em EMBO workshop: "Modern DNA concepts and tools for safe gene transfer and modification", 2015. Nóbrega, Clévio David Rodrigues. "Hypothalamic ataxin-2 regulates energy balance and metabolism". Trabalho apresentado em Keystone Symposia, Neural Control of Metabolic Physiology and Diseases, 2015. Nóbrega, Clévio David Rodrigues. "Neuropeptide Y rescues the aging phenotype of a mouse model of human premature aging". Trabalho apresentado em XII CNC Anual Meeting, 2014. Nóbrega, Clévio David Rodrigues. "Cerebellar transplantation of mesenchymal stem cells alleviates motor impairments and neuropathology in a transgenic mouse model of Machado-Joseph disease". Trabalho apresentado em XII CNC Anual Meeting, 2014. Nóbrega, Clévio David Rodrigues. "Association between obesity and polymorphisms in MSRA, TFAP2B, MC4R, NRXN3, PPARGC1A, TMEM18, SEC16B, HOXB5, and OLFM4 genes among Portuguese children". Trabalho apresentado em 21st European Congress on Obesity (ECO2014), 2014. Nóbrega, Clévio David Rodrigues. "Translational inhibition in Machado-Joseph disease: Ataxin-2 as a new molecular target". Trabalho apresentado em 5th Ataxia Investigators Meeting (AIM), 2014. Nóbrega, Clévio David Rodrigues. "Modulation of catalytic activity and polyQ toxicity by phosphorylation in spinocerebellar ataxia type 3". Trabalho apresentado em 5th Ataxia Investigators Meeting (AIM), 2014. Nóbrega, Clévio David Rodrigues. "Autophagy activation mitigates motor and neuropathological deficits in mouse models of Machado-Joseph disease". Trabalho apresentado em 5th Ataxia Investigators Meeting (AIM), 2014. Nóbrega, Clévio David Rodrigues. "Autophagy activation mitigates motor and neuropathological deficits in mouse models of Machado-Joseph disease". Trabalho apresentado em 5th Ataxia Investigators Meeting (AIM), 2014. Nóbrega, Clévio David Rodrigues. "Transplantation of cerebellar neural stem cells alleviates neuropathology and motor impairments in Machado Joseph Disease". Trabalho apresentado em 5th Ataxia Investigators Meeting (AIM), 2014. Nóbrega, Clévio David Rodrigues. "Post-translational modifications and polyglutamine diseases: the effects of ataxin-3 phosphorylation". Trabalho apresentado em Champalimaud Neuroscience Programme Symposium, 2013. Nóbrega, Clévio David Rodrigues. "Ataxin-3 phosphorylation and its effects on protease activity and Machado-Joseph disease mechanisms". Trabalho apresentado em 13th Meeting of the Portuguese Society for Neuroscience (SPN), 2013. Nóbrega, Clévio David Rodrigues. "Neuropeptide Y ameliorates the phenotype of a mouse model of human premature aging". Trabalho apresentado em 7th Progeria Research Foundation International Workshop – Hand in Hand: Basic and Clinical Science Working Together Toward the Cure, 2013. Nóbrega, Clévio David Rodrigues. "Ataxin-3 phosphorylation and its effects on protease activity and Machado-Joseph disease mechanisms". Trabalho apresentado em X Center for Neuroscience and Cell Biology (CNC) Annual Meeting, 2012. Nóbrega, Clévio David Rodrigues. "Neuropeptide Y is an autophagy inducer in hypothalamic neurons". Trabalho apresentado em IX Center for Neuroscience and Cell Biology (CNC) Annual Meetin, 2012. Nóbrega, Clévio David Rodrigues. "Associação do polimorfismo -13910C>T à obesidade abdominal em crianças portuguesas". Trabalho apresentado em 16º Congresso Português de Obesidade, 2012. Nóbrega, Clévio David Rodrigues. "Silencing of mutant ataxin-3 rescues motor deficits and neuopathology in Machado-Joseph disease transgenic mice". Trabalho apresentado em The 8th FENS Forum of Neuroscience, 2012. Marzocchi, N.; Severi, S.; Pieri, M.; Zona, C.; Cavalcanti, S.. "Beclin-1 mitigates motor and neuropathological déficits in lentiviral and transgenic mouse models of Machado-Joseph disease". Trabalho apresentado em The 8th FENS Forum of Neuroscience, 2012. 10.2495/bio050221 Nóbrega, Clévio David Rodrigues. "RNA interference rescues cerebellar abnormalities and ataxia in a lentiviral-based model of Machado-Joseph disease". Trabalho apresentado em The National Ataxia Foundation 55th annual membership meeting, 2012. Nóbrega, Clévio David Rodrigues. "Polymorphism rs9939609 in the FTO gene is associated with obesity among Portuguese children". Trabalho apresentado em 15ª Reunião Anual da Sociedade Portuguesa de Genética Humana, 2011. Kai, Kazuharu; Saya, Hideyuki; Hortobagyi, Gabriel N.; Ueno, Naoto T.. "Excitotoxicity in cerebellar granule cells transduced with mutant ataxin-3". Trabalho apresentado em Champalimaud Neuroscience Symposium, Champalimaud Foundation, 2011. 10.1158/1538-7445.am10-2458 Nóbrega, Clévio David Rodrigues. "RNA interference rescues motor and neurological deficits in Machado-Joseph disease rodent models". Trabalho apresentado em CAG triplet disorders Gordon Research Conference, 2011. Nóbrega, Clévio David Rodrigues. "Overexpression of the autophagic beclin-1 protein mitigates motor and neuropathological deficits in lentiviral and transgenic mouse models of Machado-Joseph disease". Trabalho apresentado em CAG triplet disorders Gordon Research Conference, 2011. Nóbrega, Clévio David Rodrigues. "Overexpression of mutant ataxin-3 in mouse cerebellum induces behavioral deficits and cerebellar dysfunction". Trabalho apresentado em CAG triplet disorders Gordon Research Conference, 2011. Nóbrega, Clévio David Rodrigues. "Overexpression of mutant ataxin-3 in mouse cerebellum induces behavioral deficits and cerebellar dysfunction". Trabalho apresentado em 40th annual meeting of the Society for Neurosciences, 2010. Nóbrega, Clévio David Rodrigues. "Lentiviral injection of mutant ataxin-3 in mouse cerebellum induces behavioral deficits and cerebellar dysfunction: can beclin-1 overexpression improve the pathological phenotype?". Trabalho apresentado em 18th ESGCT Annual Congress, 2010. Nóbrega, Clévio David Rodrigues. "Overexpression of mutant ataxin-3 in mousecerebellum induces behavioral deficits". Trabalho apresentado em Harvard Medical School: Molecular Mechanism in Neurodegeneration: from molecule to cure, 2010. Nóbrega, Clévio David Rodrigues. "Inhibition of mutant ataxin¬3 proteolysis by calpains in a lentiviral mouse model of Machado-Joseph disease". Trabalho apresentado em 11th Meeting of the Portuguese Society for Neurosciences, 2009. Nóbrega, Clévio David Rodrigues. "Inhibition of calpains prevents translocation of mutant ataxin¬3 to the nucleus and reduces neurodegeneration in a lentiviral mouse model of Machado¬Joseph Disease". Trabalho apresentado em IV Meeting on the Molecular Mechanisms of Neurodegeneration, 2009. Nóbrega, Clévio David Rodrigues. "Inhibition of calpains in a lentiviral mouse model of Machado¬Joseph Disease". Trabalho apresentado em CONSERT labcourse, Advanced Couse Symposium and Pratical Training, 2008. Nóbrega, Clévio David Rodrigues. "A new therapeutic approach to AMD (degenerative macular age-related disease)". Trabalho apresentado em CONSERT labcourse, Advanced Couse Symposium and Pratical Training, 2008. Nóbrega, Clévio David Rodrigues. "A multilocus survey of nucleotide variation in Drosophila madeirensis, an endemic species to Madeira Island". Trabalho apresentado em XIX European Drosophila Research Conference, 2005.
Resumo em conferência	Nóbrega, Clévio David Rodrigues. "PERMANENT INACTIVATION OF THE ATXN3 GENE: A POSSIBLE THERAPEUTIC APPROACH FOR MACHADO-JOSEPH DISEASE". 2021. Publicado • 10.1097/MD.0000000000023585 Nóbrega, Clévio David Rodrigues. "MITIGATING THE PROGEROID PHENOTYPE: A GENE DELIVERY STRATEGY TO IMPROVE PROGERIN-ASSOCIATED ABNORMALITIES". 2021. Aceite para publicação • 10.1097/MD.0000000000023585 Nóbrega, Clévio David Rodrigues. "AN RNA BINDING PROTEIN ALLEVIATES PATHOLOGY IN TWO DIFFERENT MOUSE MODELS OF POLYGLUTAMINE DISEASES". 2021. Publicado • 10.1097/MD.0000000000023585 Nóbrega, Clévio David Rodrigues. "AUTOPHAGY IMPAIRMENT IN SPINOCEREBELLAR ATAXIA TYPE 2: FIRST EVIDENCES AND A POTENTIAL THERAPEUTIC STRATEGY". 2021. 10.1097/MD.0000000000023585 Nóbrega, Clévio David Rodrigues. "SILENCING ATXN2 EXPRESSION USING CRISPR/CAS9". 2021. Publicado • 10.1097/MD.0000000000023585 Nóbrega, Clévio David Rodrigues. "CYP46A1- gene therapy improves Machado-Joseph disease in mouse models". 2020. Publicado Nóbrega, Clévio David Rodrigues. "Hypothalamic ataxin-2 prevents obesity through the regulation of the circadian clock". 2020. Publicado • 10.1111/obr.13115 Nóbrega, Clévio David Rodrigues. "Repeated transplantation of mesenchymal stromal cells in Machado-Joseph disease/Spinocerebellar ataxia type-3 mice can sustainably alleviate phenotypic symptoms and ameliorations can be monitored through magnetic resonance spectroscopy". 2019. Publicado Nóbrega, Clévio David Rodrigues. "TALEN and CRISPR Gene-Editing for Treatment of Machado-Joseph Disease". 2018. Publicado Nóbrega, Clévio David Rodrigues. "Machado-Joseph disease: from pathogenic mechanisms to therapeutic strategies". 2017. Publicado Nóbrega, Clévio David Rodrigues. "Neuropeptide Y1 and Y5 receptors activation stimulate autophagic flux in mouse hypothalamic neurons". 2016. Publicado • 10.1016/j.npep.2015.11.035 Nóbrega, Clévio David Rodrigues. "Role of MicroRNA deregulation in Machado-Joseph disease". 2015. https://doi.org/10.1016/S1525-0016(16)34191-0 Nóbrega, Clévio David Rodrigues. "MicroRNA-139-5p: a tool for metastasis and chemotherapeutic resistance control in pancreatic adenocarcinoma". 2014. Publicado Osokina, Irina. "Association study of several common polymorphisms with obesity and obesity-related traits among Portuguese children". 2014. Publicado • 10.1136/archdischild-2019-epa.639 Nóbrega, Clévio David Rodrigues. "Activation of autophagy rescues behavioral and neuropathological cerebellar deficits in a lentiviral mouse model of Machado-Joseph disease". 2013. Publicado Albuquerque, David; Jacobs, J; Nóbrega, Clévio David Rodrigues; Hanen, Samouda; Manco, Licínio; Nóbrega, Clévio David Rodrigues. "The common rs9939609 polymorphism of the Fat Mass and Obesity-associated (FTO) gene is associated with obesity in Portuguese children". Trabalho apresentado em 19th European Congress on Obesity (ECO2012), Lyon, 2012. Publicado • 10.1159/000228822 Nóbrega, Clévio David Rodrigues. "Silencing of mutant ataxin-3 rescues motor deficits and neurological abnormalities in Machado-Joseph disease transgenic mice". 2011. Publicado Nóbrega, Clévio David Rodrigues. "Activation of autophagy rescues behavioral and neuropathological cerebellar deficits in a lentiviral mouse model of Machado-Joseph disease". 2010. Publicado Nóbrega, Clévio David Rodrigues. "Inhibition of mutant ataxin-3 proteolysis by calpains in a lentiviral mouse model of Machado-Joseph disease". 2009. Publicado
Tese / Dissertação	Nóbrega, Clévio David Rodrigues. "A multilocus comparative study of nucleotide variation in Drosophila madeirensis and the close relative D. subobscura: insights into the speciation process of D. madeirensis". Doutoramento, 2007. http://hdl.handle.net/10400.13/1429.
Website	Nóbrega, Clévio David Rodrigues. Mammalian stress granules proteome. 2019. https://msgp.pt/.

Propriedade Intelectual

Patente

Nóbrega, Clévio David Rodrigues ; Koppenol, Rebekah; Conceição, André; Marcelo, Adriana. 2022. "ISOLATED OR ARTIFICIAL NUCLEOTIDES FOR USE IN NEURODEGENERATIVE DISEASES". Pendente Nóbrega, Clévio David Rodrigues. 2018. "Expression vector for cholesterol 24-hydrolase in therapy of polyglutamine repeat spinocerebellar ataxias". Concedida/Emitida Nóbrega, Clévio David Rodrigues. 2014. "Neuropeptide Y overexpression for use in the treatment of premature aging". Concedida/Emitida

Outros

Outra produção

Polyglutamine disorders preface. 2018. Nóbrega, Clévio; Almeida, Luís Pereira de. http://hdl.handle.net/10400.1/11962. 10.1007/978-3-319-71779-1

Prémio

2018	Janssen Innovation Award (2nd edition)
2017	Young Scientist Lectureship Award
2016	Human Genetics Portuguese Society Award