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Identificação

Identificação pessoal

Nome completo
Paulo Linhares

Nomes de citação

  • Linhares, Paulo

Identificadores de autor

Ciência ID
DF13-CDAA-F656

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador independente (B1) Utilizador proficiente (C1) Utilizador independente (B1) Utilizador independente (B1)
Francês Utilizador independente (B1) Utilizador proficiente (C1) Utilizador independente (B1) Utilizador independente (B1)
Espanhol; Castelhano Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador independente (B1) Utilizador proficiente (C1)
Formação
Grau Classificação
2021/11/26
Concluído
 Medicina (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
"Estudo de biomarcadores em glioblastomas: correlação clínica e molecular" (TESE/DISSERTAÇÃO)
1994
Concluído
 Medicina (Licenciatura)
Universidade do Porto Faculdade de Medicina, Portugal
 13
Percurso profissional

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2015 - Atual Grau de Consultor em Neurocirurgia Centro Hospitalar Universitário de São João, Portugal
1994 - Atual Especialidade de Neurocirurgia Hospital de São João, Portugal
Produções

Publicações

Artigo em revista
  1. Peltola, Jukka; Colon, Albert J.; Pimentel, José; Coenen, Volker A.; Gil-Nagel, Antonio; Gonçalves Ferreira, Antonio; Lehtimäki, Kai; et al. "Deep Brain Stimulation of the Anterior Nucleus of the Thalamus in Drug-Resistant Epilepsy in the MORE Multicenter Patient Registry". Neurology 100 18 (2023): http://dx.doi.org/10.1212/wnl.0000000000206887.
    10.1212/wnl.0000000000206887
  2. Bastos, António G. P.; Carvalho, Bruno; Silva, Roberto; Leitão, Dina; Linhares, Paulo; Vaz, Rui; Lima, Jorge. "Endoglin (CD105) and proliferation index in recurrent glioblastoma treated with anti-angiogenic therapy". Frontiers in Oncology 12 (2022): http://dx.doi.org/10.3389/fonc.2022.910196.
    10.3389/fonc.2022.910196
  3. Valente Aguiar, Pedro; Silveira, Fernando; Vaz, Rui; Linhares, Paulo; Pereira, Paulo. "Perineal and foot muscle synkinesis following trauma to the sacrum in an adult male – A case of motor root ephaptic transmission?". Clinical Neurology and Neurosurgery 219 (2022): 107340. http://dx.doi.org/10.1016/j.clineuro.2022.107340.
    10.1016/j.clineuro.2022.107340
  4. Valente Aguiar, Pedro; Sousa, Osvaldo; Silva, Roberto; Vaz, Rui; Linhares, Paulo. "Early atypical malignant transformation of diffuse low-grade astrocytoma: The importance of genotyping". Neurocirugía (English Edition) 33 1 (2022): 31-34. http://dx.doi.org/10.1016/j.neucie.2020.09.001.
    10.1016/j.neucie.2020.09.001
  5. Valente Aguiar, Pedro; Gonçalves, Manuel; Vaz, Rui; Linhares, Paulo. "A rare case of meningioma recurrence on a titanium mesh cranioplasty". British Journal of Neurosurgery (2021): 1-4. http://dx.doi.org/10.1080/02688697.2021.1995592.
    10.1080/02688697.2021.1995592
  6. Carvalho, Bruno; Lopes, José Manuel; Silva, Roberto; Peixoto, Joana; Leitão, Dina; Soares, Paula; Fernandes, Ana Catarina; et al. "The role of c-Met and VEGFR2 in glioblastoma resistance to bevacizumab". Scientific Reports 11 1 (2021): http://dx.doi.org/10.1038/s41598-021-85385-1.
    10.1038/s41598-021-85385-1
  7. Valente Aguiar, Pedro; Carvalho, Bruno; Monteiro, Pedro; Linhares, Paulo; Camacho, Óscar; Vaz, Rui. "Hyperbaric oxygen treatment: Results in seven patients with severe bacterial postoperative central nervous system infections and refractory mucormycosis". Diving and Hyperbaric Medicine Journal 51 1 (2021): 86-93. http://dx.doi.org/10.28920/dhm51.1.86-93.
    10.28920/dhm51.1.86-93
  8. Valente Aguiar, Pedro; Carvalho, Bruno; Vaz, Rui; Linhares, Paulo. "Body mass index as an independent prognostic factor in glioblastoma". Cancer Causes & Control (2021): http://dx.doi.org/10.1007/s10552-020-01388-9.
    10.1007/s10552-020-01388-9
  9. Valente Aguiar, Pedro; Sousa, Osvaldo; Silva, Roberto; Vaz, Rui; Linhares, Paulo. "Early atypical malignant transformation of diffuse low-grade astrocytoma: The importance of genotyping". Neurocirugía (2020): http://dx.doi.org/10.1016/j.neucir.2020.09.003.
    10.1016/j.neucir.2020.09.003
  10. Linhares, Paulo; Carvalho, Bruno; Vaz, Rui; Costa, Bruno M.. "Glioblastoma: Is There Any Blood Biomarker with True Clinical Relevance?". International Journal of Molecular Sciences 21 16 (2020): 5809. http://dx.doi.org/10.3390/ijms21165809.
    10.3390/ijms21165809
  11. Valente Aguiar, Pedro; Pinheiro, Jorge; Lima, Jorge; Vaz, Rui; Linhares, Paulo. "Myxoid mesenchymal intraventricular brain tumour with EWSR1–CREB1 gene fusion in an adult woman". Virchows Archiv (2020): http://dx.doi.org/10.1007/s00428-020-02885-7.
    10.1007/s00428-020-02885-7
  12. Carvalho, Bruno; Lopes, Rafaela Gonçalves; Linhares, Paulo; Costa, Andreia; Caeiro, Cláudia; Fernandes, Ana Catarina; Tavares, Nuno; Osório, Lígia; Vaz, Rui. "Hypertension and proteinuria as clinical biomarkers of response to bevacizumab in glioblastoma patients". Journal of Neuro-Oncology 147 1 (2020): 109-116. http://dx.doi.org/10.1007/s11060-020-03404-z.
    10.1007/s11060-020-03404-z
  13. Linhares, Paulo; Ferreira, Axel; Vaz, Rui. "The importance of the neutrophil-to-lymphocyte ratio in the prognosis of glioma and its subtypes". CNS Neuroscience & Therapeutics 26 3 (2019): 394-395. http://dx.doi.org/10.1111/cns.13270.
    10.1111/cns.13270
  14. Viana-Pereira, Marta; Moreno, Daniel Antunes; Linhares, Paulo; Amorim, Júlia; Nabiço, Rui; Costa, Sandra; Vaz, Rui; Reis, Rui Manuel. "Replication of GWAS identifies RTEL1, CDKN2A/B, and PHLDB1 SNPs as risk factors in Portuguese gliomas patients". Molecular Biology Reports 47 2 (2019): 877-886. http://dx.doi.org/10.1007/s11033-019-05178-8.
    10.1007/s11033-019-05178-8
  15. Soares, Carolina; Vilas-Boas, Maria do Carmo; Lopes, Elodie Murias; Choupina, Hugo; Soares-dos-Reis, Ricardo; Fitas, Diogo; Cunha, João Paulo Silva; et al. "Automated and objective measures of gait dynamics in camptocormia Parkinson’s Disease subthalamic deep brain stimulation". Clinical Neurology and Neurosurgery 186 (2019): 105537. http://dx.doi.org/10.1016/j.clineuro.2019.105537.
    10.1016/j.clineuro.2019.105537
  16. Branco, Mariana; Linhares, Paulo; Carvalho, Bruno; Santos, Patrícia; Costa, Bruno M.; Vaz, Rui. "Serum lactate levels are associated with glioma malignancy grade". Clinical Neurology and Neurosurgery 186 (2019): 105546. http://dx.doi.org/10.1016/j.clineuro.2019.105546.
    10.1016/j.clineuro.2019.105546
  17. Aires, Ana; Gomes, Tiago; Linhares, Paulo; Cunha, Filipe; Rosas, Maria José; Vaz, Rui. "The impact of deep brain stimulation on health related quality of life and disease-specific disability in Meige Syndrome (MS)". Clinical Neurology and Neurosurgery 171 (2018): 53-57. http://dx.doi.org/10.1016/j.clineuro.2018.05.012.
    10.1016/j.clineuro.2018.05.012
  18. Linhares, Paulo; Viana-Pereira, Marta; Ferreira, Mónica; Amorim, Júlia; Nabiço, Rui; Pinto, Filipe; Costa, Sandra; Vaz, Rui; Reis, Rui Manuel. "Genetic variants of vascular endothelial growth factor predict risk and survival of gliomas". Tumor Biology 40 3 (2018): 101042831876627. http://dx.doi.org/10.1177/1010428318766273.
    10.1177/1010428318766273
  19. Lopes, Marta; Carvalho, Bruno; Vaz, Rui; Linhares, Paulo. "Influence of neutrophil–lymphocyte ratio in prognosis of glioblastoma multiforme". Journal of Neuro-Oncology 136 1 (2017): 173-180. http://dx.doi.org/10.1007/s11060-017-2641-3.
    10.1007/s11060-017-2641-3
  20. Martins de Campos, António; Braz, Luís; Linhares, Paulo; Rosas, Maria José. "Deep brain stimulation for Parkinson's disease: Subcutaneous apomorphine as an alternative for patients unable to tolerate surgery under local anesthesia". Journal of the Neurological Sciences 378 (2017): 137-139. http://dx.doi.org/10.1016/j.jns.2017.04.048.
    10.1016/j.jns.2017.04.048
  21. Sampaio, Luísa; Linhares, Paulo; Fonseca, José. "Detailed magnetic resonance imaging features of a case series of primary gliosarcoma". The Neuroradiology Journal 30 6 (2017): 546-553. http://dx.doi.org/10.1177/1971400917715879.
    10.1177/1971400917715879
  22. Xavier-Magalhães, Ana; Oliveira, Ana I.; de Castro, Joana Vieira; Pojo, Marta; Gonçalves, Céline S.; Lourenço, Tatiana; Viana-Pereira, Marta; et al. "Effects of the functional HOTAIR rs920778 and rs12826786 genetic variants in glioma susceptibility and patient prognosis". Journal of Neuro-Oncology 132 1 (2017): 27-34. http://dx.doi.org/10.1007/s11060-016-2345-0.
    10.1007/s11060-016-2345-0
  23. Rocha, Helena; Linhares, Paulo; Chamadoira, Clara; Rosas, Maria José; Vaz, Rui. "Early deep brain stimulation in patients with myoclonus-dystonia syndrome". Journal of Clinical Neuroscience 27 (2016): 17-21. http://dx.doi.org/10.1016/j.jocn.2015.08.034.
    10.1016/j.jocn.2015.08.034
  24. Vieira de Castro, Joana; Gonçalves, Céline S.; Costa, Sandra; Linhares, Paulo; Vaz, Rui; Nabiço, Ricardo; Amorim, Júlia; et al. "Impact of TGF-ß1 -509C/T and 869T/C polymorphisms on glioma risk and patient prognosis". Tumor Biology 36 8 (2015): 6525-6532. http://dx.doi.org/10.1007/s13277-015-3343-0.
    10.1007/s13277-015-3343-0
  25. Pereira, AndréF; Carvalho, BrunoF; Vaz, RuiM; Linhares, PauloJ. "Glioblastoma in the elderly: Therapeutic dilemmas". Surgical Neurology International 6 24 (2015): 573. http://dx.doi.org/10.4103/2152-7806.169542.
    10.4103/2152-7806.169542
  26. Carvalho, Bruno F.; Fernandes, Ana C.; Almeida, Daniela S.; Sampaio, Luísa V.; Costa, Andreia; Caeiro, Claudia; Osório, Lígia; et al. "Second-Line Chemotherapy in Recurrent Glioblastoma: A 2-Cohort Study". Oncology Research and Treatment 38 7-8 (2015): 348-354. http://dx.doi.org/10.1159/000431236.
    10.1159/000431236
  27. França, Sara; Massano, João; Linhares, Paulo; Rosas, Maria José; Volkmann, Jens. "Pallidal Deep Brain Stimulation in DYT6: Significant Long-Term Improvement of Dystonia and Disability". Movement Disorders Clinical Practice 1 2 (2014): 118-120. http://dx.doi.org/10.1002/mdc3.12019.
    10.1002/mdc3.12019
  28. Pandey, Janardan P; Kaur, Navtej; Costa, Sandra; Amorim, Julia; Nabico, Rui; Linhares, Paulo; Vaz, Rui; Viana-Pereira, Marta; Reis, Rui M. "Immunoglobulin genes implicated in glioma risk". OncoImmunology 3 5 (2014): e28609. http://dx.doi.org/10.4161/onci.28609.
    10.4161/onci.28609
  29. Calheiros-Trigo, Francisca; Linhares, Paulo. "Evaluation of the efficacy of deep brain stimulation in the surgical treatment of cervical dystonia". Neurocirugía 25 2 (2014): 49-55. http://dx.doi.org/10.1016/j.neucir.2013.10.004.
    10.1016/j.neucir.2013.10.004
  30. Silva, PedroAlberto; Chamadoira, Clara; Costa, Henrique; Linhares, Paulo; Rosas, MariaJose; Vaz, Rui. "Twiddler (or Not) Syndrome: Questioning etiology for an uncommon form of hardware malfunction in deep brain stimulation". Surgical Neurology International 5 9 (2014): 410. http://dx.doi.org/10.4103/2152-7806.140201.
    10.4103/2152-7806.140201
  31. Carvalho, Ana Teresa; Linhares, Paulo; Castro, Lígia; Sá, Maria José. "Multiple Sclerosis and Oligodendroglioma: An Exceptional Association". Case Reports in Neurological Medicine 2014 (2014): 1-5. http://dx.doi.org/10.1155/2014/546817.
    10.1155/2014/546817
  32. Rocha, Sofia; Monteiro, Ana; Linhares, Paulo; Chamadoira, Clara; Basto, Margarida Ayres; Reis, Carina; Sousa, Cláudia; et al. "Long-Term Mortality Analysis in Parkinson’s Disease Treated with Deep Brain Stimulation". Parkinson's Disease 2014 (2014): 1-5. http://dx.doi.org/10.1155/2014/717041.
    10.1155/2014/717041
  33. Pereira, Erlick A. C.; Boccard, Sandra G.; Linhares, Paulo; Chamadoira, Clara; Rosas, Maria José; Abreu, Pedro; Rebelo, Virgínia; Vaz, Rui; Aziz, Tipu Z.. "Thalamic deep brain stimulation for neuropathic pain after amputation or brachial plexus avulsion". Neurosurgical Focus 35 3 (2013): E7. http://dx.doi.org/10.3171/2013.7.focus1346.
    10.3171/2013.7.focus1346
  34. Linhares, Paulo; Carvalho, Bruno; Vaz, Rui. "One-step tunneling of DBS extensions—a technical note". Acta Neurochirurgica 155 5 (2013): 837-840. http://dx.doi.org/10.1007/s00701-013-1667-3.
    10.1007/s00701-013-1667-3
  35. Brandão, Eva; Rosas, Maria José; Abreu, Pedro; Linhares, Paulo; Vaz, Rui. "Intracerebral abscess: A rare complication of deep brain stimulation". Neurocirugía 24 1 (2013): 33-36. http://dx.doi.org/10.1016/j.neucir.2011.11.008.
    10.1016/j.neucir.2011.11.008
  36. Carvalho, Bruno; Linhares, Paulo; Martinho, Olga; Castro, Lígia; Lopes, JoséManuel; Vaz, Rui; Reis, RuiManuel. "Analysis of a synchronous gliosarcoma and meningioma with long survival: A case report and review of the literature". Surgical Neurology International 4 1 (2013): 151. http://dx.doi.org/10.4103/2152-7806.122229.
    10.4103/2152-7806.122229
  37. Linhares, Paulo; Carvalho, Bruno; Figueiredo, Rita; Reis, Rui M.; Vaz, Rui. "Early Pseudoprogression following Chemoradiotherapy in Glioblastoma Patients: The Value of RANO Evaluation". Journal of Oncology 2013 (2013): 1-9. http://dx.doi.org/10.1155/2013/690585.
    10.1155/2013/690585
  38. Costa, Bruno Marques; Viana-Pereira, Marta; Fernandes, Ricardo; Costa, Sandra; Linhares, Paulo; Vaz, Rui; Pinheiro, Céline; et al. "Impact of EGFR Genetic Variants on Glioma Risk and Patient Outcome". Cancer Epidemiology Biomarkers & Prevention 20 12 (2011): 2610-2617. http://dx.doi.org/10.1158/1055-9965.epi-11-0340.
    10.1158/1055-9965.epi-11-0340
  39. Linhares, Paulo; Pires, Eugénia; Carvalho, Bruno; Vaz, Rui. "Juvenile psammomatoid ossifying fibroma of the orbit and paranasal sinuses. A case report". Acta Neurochirurgica 153 10 (2011): 1983-1988. http://dx.doi.org/10.1007/s00701-011-1115-1.
    10.1007/s00701-011-1115-1
  40. Gago, Miguel F.; Rosas, Maria José; Linhares, Paulo; Massano, João; Sarmento, António; Vaz, Rui. "Deep Brain Stimulation of the Subthalamic Nucleus for Parkinson’s Disease in a Patient with HIV Infection: Dual Clinical Benefit". Case Reports in Neurology 3 3 (2011): 219-222. http://dx.doi.org/10.1159/000332610.
    10.1159/000332610
  41. Real, Raquel; Linhares, Paulo; Fernandes, Hélder; Rosas, Maria José; Gago, Miguel F.; Pereira, Jorge; Vaz, Rui. "Role ofTc-Sulesomab Immunoscintigraphy in the Management of Infection following Deep Brain Stimulation Surgery". Neurology Research International 2011 (2011): 1-8. http://dx.doi.org/10.1155/2011/817951.
    10.1155/2011/817951
  42. Reis. "Prognostic value of MGMT promoter methylation in glioblastoma patients treated with temozolomide-based chemoradiation: A Portuguese multicentre study". Oncology Reports 23 6 (2010): http://dx.doi.org/10.3892/or_00000808.
    10.3892/or_00000808
  43. Rodrigues, Ana M.; Rosas, Maria J.; Gago, Miguel F.; Sousa, Cláudia; Fonseca, Rosália; Linhares, Paulo; Basto, Margarida A.; et al. "Suicide Attempts after Subthalamic Nucleus Stimulation for Parkinson’s Disease". European Neurology 63 3 (2010): 176-179. http://dx.doi.org/10.1159/000289097.
    10.1159/000289097
  44. Mendes, V.; Castro, S.; Linhares, P.; Ribeiro-Silva, M.L.. "Tumoriform presentation of cerebral candidiasis in an HIV-infected patient". Journal of Clinical Neuroscience 16 4 (2009): 587-588. http://dx.doi.org/10.1016/j.jocn.2008.05.026.
    10.1016/j.jocn.2008.05.026
  45. Gago, M.F.; Rosas, M.J.; Linhares, P.; Ayres-Basto, M.; Sousa, G.; Vaz, R.. "Transient Disabling Dyskinesias: A Predictor of Good Outcome in Subthalamic Nucleus Deep Brain Stimulation in Parkinson’s Disease". European Neurology 61 2 (2008): 94-99. http://dx.doi.org/10.1159/000177941.
    10.1159/000177941
  46. Mendes, Virgínia C.; Linhares, Paulo; Fonseca, Elsa; Ribeiro-Silva, M. Luís. "Giant skull metastasis of Hürthle cell variant of thyroid’s papillary carcinoma". Journal of Neuro-Oncology 86 3 (2007): 311-312. http://dx.doi.org/10.1007/s11060-007-9503-3.
    10.1007/s11060-007-9503-3
  47. Linhares, P.; Aran, E.; Gonçalves, J.M.; Vaz, R.; Castro, L.. "Biopsias estereotáxicas: Revisión de una serie de 80 casos. ¿Está justificada la realización de una tomografía computarizada (TC) en las primeras horas tras el procedimiento?". Neurocirugía 13 4 (2002): 299-303. http://dx.doi.org/10.1016/s1130-1473(02)70603-9.
    10.1016/s1130-1473(02)70603-9
Capítulo de livro
  1. FERNANDES, CATARINA; COSTA, ANDREIA; OSÓRIO, LÍGIA; LAGO, RITA COSTA; LINHARES, PAULO; CARVALHO, BRUNO; CAEIRO, CLÁUDIA. "Current Standards of Care in Glioblastoma Therapy". In Glioblastoma, 197-241. Codon Publications, 2017.
    10.15586/codon.glioblastoma.2017.ch11
  2. Linhares, Paulo. "Técnica cirurgica". In Estimulação Cerebral Profunda: do tratamento da doença de Parkinson a uma nova visão do funcionamento do cérebro. Edições Bial, 2012.
  3. Linhares, Paulo. "Ossifying fibromas of the craniofacial skeleton". In Histopathology. Intech, 2012.
    Publicado
  4. Linhares, Paulo. "Tumores cerebrais". In Neurologia clínica. Edições Universidade Fernando Pessoa, 2009.
  5. Linhares, Paulo. "Traumatismos cranio-encefálcos". In Neurologia clinica. Compreender as doenças neurológicas. Edições Universidade Fernando Pessoa, 2009.
Distinções

Prémio

2010 Prémio Bial 2010 - Menção Honrosa
Fundação Bial, Portugal

Outra distinção

2006 Prémio Novartis de Neurologia
Sociedade Portuguesa de Neurologia, Portugal
2003 Prémio Codman da Melhor comunicação oral