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Sofia Lima (SL) is an Assistant Researcher at ICBAS - Abel Salazar Institute of Biomedical Sciences and LAQV/REQUIMTE position awarded by the CEEC Institutional under One Health Initiative. Completed the PhD in Chemistry in 2007 at the Universidade do Porto Faculdade de Ciências, and the International Master of Science in Biotechnology in 1999 by De Montfort University, United Kingdom. SL graduated in Microbiology in 1998 by Universidade Católica Portuguesa Escola Superior de Biotecnologia. SL is focused in the study of cell-nanomaterials interactions using biochemical and biophysical techniques, to unravel related mechanisms of action. Improve knowledge on nanomaterials safety is crucial to assure their emerging introduction in consumer goods (food and health). SL interest in the development of drug delivery systems able to overcome the barriers (skin and gastrointestinal) lead to the exploitation of natural compounds as tools to enhance permeation and thus modulate biological processes. Published 93 articles in journals (75% Q1), 89 were published independently from SL's PhD supervisor and 35 as corresponding author. SL has an h-index of 30 (scopus) and was cited over 2850 times. SL is also the editor of 2 books, 4 invited book chapters and a national patent. SL supervised 3 PhD thesis and is the main supervisor of 2 PhD students and co-supervisor of 3. Supervised or co-supervised 16 MSc dissertation(s) and participated in the supervision of students (12) on a mobility program from Morocco, Italy, the United Kingdom, Croatia, Greece, Malasia and Turkey. Has received 11 awards and/or honors. Participates and/or participated as Principal investigator in 8 project(s) and Researcher in 18 project(s) funded by national or international funds. SL actively participates in COST Actions and in science awareness activities. SL participated in short-term scientific missions to different national and international laboratories in order to widen her scientific knowledge and know-how (e.g. Alba synchrotron, Barcelona). SL has been involved in several grant reviewing processes for international funding agencies (GWIS; NSC - Poland; ISF - Israel; University of Porto - Portugal; University Bordeaux and ANR - France; European Commission). Additionally, SL has been in the organization of Advanced Courses and Hands-on-Workshops. Works in the area(s) of Chemistry (mainly, polymer chemistry and colloidal chemistry) and Health Sciences with emphasis on Immunology and Nanomaterials for Pharmaceutical and Food applications. keywords: animal nutrition; marine-based hydrogels; fucoidan/chitosan nanoparticles; mannosylated nanoparticles; gold nanoparticles; lipid nanoparticles; liposomes; cutaneous leishmaniasis; leprae; leishmaniose; sleeping sickness; atopic dermatitis; psoriasis; magnetic hyperthermia; nutraceuticals; pH-responsive nanoparticles; photodynamic therapy; PLA nanoparticles; PLGA nanoparticles; pegylated nanoparticles; theranostic nanoparticles.
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Identification

Personal identification

Full name
Sofia Lima

Author identifiers

Ciência ID
0013-8CA6-2D1C
ORCID iD
0000-0001-8777-5877
Researcher Id
D-7026-2013
Scopus Author Id
57216898243

Email addresses

  • slima@ff.up.pt (Professional)
  • slima@icbas.up.pt (Professional)

Addresses

  • Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto. Rua de Jorge Viterbo Ferreira, 228, 4050-313, Porto, Porto, Portugal (Professional)

Websites

Knowledge fields

  • Exact Sciences - Chemical Sciences - Polymer Science
  • Exact Sciences - Chemical Sciences - Colloid Chemistry
  • Medical and Health Sciences - Health Sciences - Infectious Diseases
  • Medical and Health Sciences - Basic Medicine - Immunology
  • Engineering and Technology - Nano-technology - Nano-materials

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Intermediate (B1) Advanced (C1)
English Advanced (C1) Advanced (C1) Intermediate (B1) Advanced (C1)
French Beginner (A1) Intermediate (B1) Beginner (A1) Beginner (A1)
Spanish; Castilian Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2007/11/07
Concluded
 PhD in Chemistry (Doutoramento)
Universidade do Porto Faculdade de Ciências, Portugal
"Structural and functional activity of P-glycoprotein membrane transporter in the presence of benzodiazepines and tuberculostatic drugs. " (THESIS/DISSERTATION)
1999/07/31
Concluded
 International Master of Science in Biotechnology (Mestrado)
De Montfort University, United Kingdom
"Production of oral vaccines in "Solanum tuberosum L"" (THESIS/DISSERTATION)
1998/06/30
Concluded
 Microbiology (Licenciatura)
Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
"Identification of "Serra da Estrela" Cheese isolated lactic bacteria by SDS-PAGE" (THESIS/DISSERTATION)
Affiliation

Science

Category
Host institution 		Employer
2022/09/01 - Current Auxiliary Researcher (Research) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
2019/04/06 - 2022/08/31 Auxiliary Researcher (Research) REQUIMTE, Portugal
REQUIMTE LAQV Porto, Portugal
2016/04/06 - 2019/04/05 Researcher (Research) REQUIMTE LAQV Porto, Portugal
Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal
2013/03/18 - 2015/06/30 Researcher (Research) REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
REQUIMTE, Portugal
2007/11/15 - 2013/03/17 Researcher (Research) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2002/03/01 - 2007/11/07 Researcher (Research) REQUIMTE, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2021/09/25 - 2022/07/31 Invited Assistant Professor (University Teacher) Instituto Universitário de Ciências da Saúde, Portugal
2020/09/14 - 2021/07/31 Invited Assistant Professor (University Teacher) Instituto Universitário de Ciências da Saúde, Portugal
2019/10/01 - 2020/07/31 Invited Assistant Professor (University Teacher) Instituto Universitário de Ciências da Saúde, Portugal
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2018/10/01 - 2019/02/28 Invited Assistant Professor (University Teacher) Instituto Universitário de Ciências da Saúde, Portugal
2017/10/01 - 2018/02/28 Invited Assistant Professor (University Teacher) Instituto Universitário de Ciências da Saúde, Portugal
2016/10/01 - 2017/02/28 Invited Assistant Professor (University Teacher) Instituto Universitário de Ciências da Saúde, Portugal
2015/10/01 - 2016/02/28 Invited Assistant Professor (University Teacher) Instituto Universitário de Ciências da Saúde, Portugal
Instituto Universitário de Ciências da Saúde, Portugal

Others

Category
Host institution 		Employer
2007/10/01 - 2008/06/30 Educational trainer Associação para a Escola Superior de Biotecnologia da Universidade Católica Portuguesa, Portugal
2007/03/01 - 2007/06/29 Educational trainer Forpime, Portugal
2000/03/01 - 2002/02/28 Invited Assistant Lecturer Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
1999/11/02 - 2001/12/31 Researcher Assistant Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
1999/02/01 - 1999/07/30 Graduated researcher Wageningen University and Research Wageningen Plant Research, Netherlands
1997/10/01 - 1998/07/31 Undergraduated Researcher Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
Projects

Grant

Designation Funders
2002/03/01 - Current Avaliação do efeito de iões de metais de transição no transporte de fármacos pela P-glicoproteína
PRAXIS XXI BD/4613/2001)
PhD Student Fellow
Fundação para a Ciência e a Tecnologia
2002 - Current Evaluation of the structure and function of P-glycoprotein, membrane transporter, in the presence of benzodiazepines and tuberculostatics
BPD/37880/2007
PhD Student Fellow
Universidade do Porto Faculdade de Ciências, Portugal
 Fundação para a Ciência e a Tecnologia
1998 - Current Production of oral vaccines in Solanum tuberosum L
PRAXIS XXI BM/20357/98
Master Student Fellow
Fundação para a Ciência e a Tecnologia
2008/04/01 - 2013/03/15 Development of BNIP polyamine drug delivery systems, liposome and nanoparticles, to target specially Leishmania infected macrophages and dendritic cells
BPD/37880/2007
 Fundação para a Ciência e a Tecnologia
1998/04/01 - 2000/03/31 Mare Nostrum
Ministerio Defesa Nacional
Researcher
Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
 Governo da Republica Portuguesa Ministério da Defesa Nacional
1999/01/01 - 1999/06/30 Production of oral vaccines in Solanum tuberosum L.
PRAXIS XXI BM/20357/98
Master Student Fellow
De Montfort University, United Kingdom
 Fundação para a Ciência e a Tecnologia

Contract

Designation Funders
2022/10/01 - Current NovInDog - Novos Ingredientes Proteicos Funcionais para a Alimentação de Cães: uma Abordagem Sustentável
POCI-01-0247-FEDER-047003
Researcher
Ongoing
2022/09/01 - 2028/08/31 Nanotechnological approaches for animal health and growth towards a sustainable environment
CEECINST/00007/2021/CP2775/CT0001
10.54499/CEECINST/00007/2021/CP2775/CT0001
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2025/02/01 - 2026/07/31 Advanced Nanotechnology for Functional Nutrition in Aquaculture
2023.14508.PEX
Principal investigator
Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
2021/01/01 - 2025/12/31 Laboratório Associado para a Química Verde - Tecnologias e Processos Limpos
LA/P/0008/2020
10.54499/LA/P/0008/2020
Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade Nova de Lisboa, Portugal

Unidade de Investigação Vidro e Cerâmica para as Artes, Portugal

Universidade de Aveiro, Portugal

Universidade de Évora, Portugal

Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2022/01/01 - 2024/06/30 CoSki - Collaborative Initiative for Skin Research
EEA Grant
Principal investigator
REQUIMTE LAQV Porto, Portugal
 EEA Grants
Ongoing
2022/01/01 - 2023/06/30 Cellulose-based iron nanofertilizers for sustainable growth of soybean plants
EXPL/QUI-QIN/0411/2021
Researcher
REQUIMTE LAQV Porto, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2022/04/01 - 2023/03/31 Bacterial cell-specific targeting and nanoparticle-mediated bactericidal action against the most common pathogens colonizing diabetic foot ulcers
ESCMID Research Grants 2022
Researcher
Universidade do Minho, Portugal

REQUIMTE LAQV Porto, Portugal
European Society of Clinical Microbiology and Infectious Diseases
2022/04 - 2023/03 Bacterial cell-specific targeting and nanoparticle-mediated bactericidal action against the most common pathogens colonizing diabetic foot ulcers
ESCMID Research Grants 2022
 European Society of Clinical Microbiology and Infectious Diseases
2022/11/02 - 2022/11/06 The effect of marine polymers-based nanoparticles on the skin structural organization towards skin delivery.
2021025041
Principal investigator
Alba Synchroton
Concluded
2019/04/06 - 2022/08/31 SeaNano4sNTDs: Marine-based nanotechnological approaches for skin-related Neglected Tropical Diseases therapies
CEECIND/01620/2017/CP1427/CT0002
10.54499/CEECIND/01620/2017/CP1427/CT0002
Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018/07/01 - 2021/06/30 3Ds – transDermic aDministration of Drugs
PTDC/QUI-COL/30834/2017
Principal investigator
REQUIMTE LAQV Porto, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/07/01 - 2021/06/30 Circumventing surgical removal of biofilms infected implants: a nano-based, selective and targeted approach
PTDC/NAN-MAT/31444/2017
Researcher
REQUIMTE LAQV Porto, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2020/07/08 - 2021/01/08 nano2Prevent
nano2Prevent
Researcher
REQUIMTE LAQV Porto, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2019/01/01 - 2019/12/31 Unidade de Ciências Biomoleculares Aplicadas
UID/Multi/04378/2019
Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Universidade do Porto Faculdade de Ciências, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2016/06/01 - 2019/05/31 Navigating through marine-derived fungi: bioprospection and synthesis of bioactive secondary metabolites and analogues as chemotherapic agents
PTDC/MAR-BIO/4694/2014
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2012/05/05 - 2015/05/04 Cell communication by Leishmania microvesicles
Provided by PTCRIS: 118644
Researcher
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciência e a Tecnologia
2012/10 - 2013/12 Therapeutic efficacy and safety of BNIPDaoct-loaded PLGA nanoparticles for the treatment of visceral leishmaniasis
IJUP2011-227
 Banco Santander Totta
2011/03 - 2013/12 Development of new drug delivery systems based on bisnaphthalimidopropyl derivatives compounds liposomal formulation for pancreatic cancer and leishmaniasis drug therapy
Provided by PTCRIS: 113151
PTDC/ SAU-ENB/ 113151/ 2009
Principal investigator
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2011/04/01 - 2013/03/31 Development of a new immunological screening method for leishmaniasis using colloidal gold nanoparticles
info:eu-repo/grantAgreement/FCT/5876-PPCDTI/110732/PT
Provided by PTCRIS: 110732
Researcher
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Universidade do Algarve Faculdade de Ciências e Tecnologia

Fundação para a Ciência e a Tecnologia
2009/11/01 - 2012/12/31 Nanotechnology as a tool towards Leishmaniasis and Human African Trypanosomiasis therapy
P-105348
Principal investigator
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Fundação Calouste Gulbenkian
Concluded
2011/01/01 - 2011/12/31 Evaluation of anti-Leishmania compounds released from polymeric nanoparticles
projeto 155
Principal investigator
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Banco Santander Totta
Concluded
2011/01/01 - 2011/12/31 Lipid nanocarriers for dermal and transdermal drug delivery intending the treatment of cellulite by inducing adipocytes lipolysis
Pluridisciplicar 98
Researcher
REQUIMTE LAQV Porto, Portugal
 Banco Santander Totta
2006/10/01 - 2009/12/31 The Leishmania TDR1 family-related gene: functional studies and evaluation of TDR1 recombinant protein and knockout vaccines against leishmaniasis.
Provided by PTCRIS: 65047
PTDC/CVT/65047/2006
Researcher
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Other

Designation Funders
2024/03/20 - Current COST Action CA22160 - Enhancing knowledge of BIOmolecular solutions for the well-being of European AQUAculture sector (BIOAQUA)
CA22160
Researcher
2022/09/26 - Current COST Action CA21108 - European Network for Skin Engineering and Modeling
CA21108
Researcher
2024/10/22 - 2028/10/21 COST Action CA23132 - Magnetic Particle Imaging for next-generation theranostics and medical research (NexMPI)
CA22160
Researcher
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Ongoing
2019/04/04 - 2022/08/31 SeaNano4sNTDs: Marine-based nanotechnological approaches for skin-related Neglected Tropical Diseases therapies
CEECIND/01620/2017
Principal investigator
Fundação para a Ciência e a Tecnologia
2021/11/30 - 2022/05/31 C19-VisualDetect
C19-VisualDetect
Researcher
REQUIMTE LAQV Porto, Portugal
 Universidade do Porto
Ongoing
2018 - 2022 CA16205: European Network on Understanding Gastrointestinal Absorption-related Processes (UNGAP)
CA16205
Researcher
European Cooperation in Science and Technology, Belgium
 European Cooperation in Science and Technology
2016/04/07 - 2019/03/30 FOODnanoHEALTH - Qualidade e Segurança Alimentar – uma abordagem (nano)tecnológica
NORTE-01-0145-FEDER-000011
Researcher
Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal
 Comissao de Coordenacao e Desenvolvimento Regional do Norte
Concluded
2014 - 2018 CM1307 "Targeted chemotherapy towards diseases caused by endoparasites"
CM1307
Researcher
European Cooperation in Science and Technology, Belgium
 European Cooperation in Science and Technology
2014 - 2018 TD1402 "Multifunctional Nanoparticles for Magnetic Hyperthermia and Indirect Radiation Therapy (RADIOMAG)"
TD1402
Researcher
European Cooperation in Science and Technology, Belgium
 European Cooperation in Science and Technology
2013/03/17 - 2015/06/30 Nanoquímica
Norte-07-0124-FEDER-000067
Researcher
Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
Concluded
2012 - 2014 TD1004 "Theranostics Imaging and Therapy: An Action to Develop Novel Nanosized Systems for Imaging-Guided Drug Delivery"
TD 1004
Researcher
European Cooperation in Science and Technology, Belgium
 European Cooperation in Science and Technology
Outputs

Publications

Book
  1. Polymeric Carriers for Biomedical and Nanomedicine Application. 2021.
    Published • Editor
Book chapter
  1. Ana Isabel Barbosa; Raquel Costa; Tânia Moniz; Costa Lima, S.A.; Salette Reis. "Nanostrategies for skin delivery: tools for skin inflammatory diseases topical therapy". In The Road from Nanomedicine to Precision Medicine, edited by Shaker A Mousa; Raj Bawa; Gerald F Aude. Jenny Stanford, 2022.
    Under revision
  2. Ana Isabel Barbosa; Filipa Serrasqueiro; Tânia Moniz; Costa Lima, S.A.; Salette Reis. "Marine polysaccharides for skin drug delivery: hydrogels and microneedles solutions". edited by Sougata Jana. Singapure: Springer Nature, 2022.
    Published
  3. Costa Lima, S A; Reis, Salette. "Nanotechnological Approaches in Drug Absorption through Skin Topical Delivery". In Nanoparticles in the Life Sciences and Biomedicine. Pan Stanford Publishing, 2018.
    Published
  4. Chaves, L L; Vieira, A.C.; Domingos, F; Sarmento, B; Reis, Salette; Costa Lima, S A. "Nanocarriers as a Strategy for Oral Bioavailability Improvement of Poorly Water-Soluble Drugs". In Nanoparticles in the Life Sciences and Biomedicine. Pan Stanford Publishing, 2018.
    Published
Conference poster
  1. Ferreira, Sónia ; Grenho, Liliana; Maria Helena Fernandes; Costa Lima, Sofia A.. "Development and characterization of nanoparticles with curcumin for intracanalar treatment". Paper presented in Congresso Sociedade Portuguesa de Endodontia, 2024.
  2. Shakel, Zinaida; Reis, Salette; Goril Flaten; Costa Lima, Sofia A.. "Skin permeation studies: comparing ex vivo Human Skin, porcine skin, and PVPA models". Paper presented in European Society for Dermatological Research (ESDR), 2024.
  3. Beatriz Silva; Daniela Oliveira; Reis, Salette; Costa Lima, Sofia A.. "Nanoencapsulation of Vitamin K3 for pet food fortification". Paper presented in IJUP 2024, 2024.
  4. Renata Basto; Reis, Salette; Lima, Sofia. "Polymeric nanoparticles loaded with an antioxidant defense to combat Androgenetic Alopecia". Paper presented in XXVII Encontro Luso-Galego de Química, 2023.
  5. Shakel, Zinaida; Reis, Salette. "Unlocking the potential of carrageenan-based hydrogels: skin delivery with antioxidant and anti-inflammatory properties". Paper presented in XXIVII Encontro Luso-Galego, 2023.
  6. Joana Fernandes; Carolina Barroso; Aires, Tiago; António Fonseca; Lima, Sofia; Maia, Margarida R. G.; Ana Rita Cabrita. "Evaluation of alternative marine sources as protein ingredients in pet food". Paper presented in 48th World Small Animal Veterinary Association Congress and the 28th FECAVA Eurocongress (WSAVA 2023), 2023.
  7. Daniela Oliveira; Beatriz Silva; Nuno Saraiva; Paula Gomes; Lima, Sofia; Reis, Salette. "Encapsulation of nutrients for food fortification using solid lipid nanopartiles". Paper presented in 12th International Colloid Conference, 2023.
  8. Gabriel Machado; Reis, Salette; Lima, Sofia. "Obtention and Characterization of a Polyphenol enriched extract from Olive pomace". Paper presented in Portuguese Young Chemistry Meeting, 2023.
  9. Daniela Oliveira; Beatriz Silva; Paula Gomes; Lima, Sofia; Reis, Salette. "Development and characterization of solid lipid nanoparticles formulations in nutrients delivery for animal feed fortification". Paper presented in Portuguese Young Chemistry Meeting, 2023.
  10. Renata Basto; Zinaida Sakel; Aikaterini Spanou; Ana Isabel Barbosa; Claudia Nunes; Reis, Salette; Costa Lima, S A. "Nanoplatforms drive slow down skin ageing". Paper presented in XXVI Encontro Luso-Galego de Química, 2022.
  11. Joana Fernandes; Costa Lima, S A; Maia, Margarida R. G.; Ana Rita Cabrita. "Marine sources in dog feeding: nutritive value and palatability of squid meal and shrimp hydrolysate". Paper presented in Workshop PDCA 2022, 2022.
  12. Ana Isabel Barbosa; Spanou, Aikaterini ; Reis, Salette; Lima, Sofia. "Genistein-loaded nanostrategies for skin anti-aging". Paper presented in 15º IJUP, 2022.
  13. Ana Catarina Dias; Basto, Renata; Ana Isabel Barbosa; Lima, Sofia; Reis, Salette. "Cutaneous drug delivery systems to control skin inflammation". Paper presented in 15º IJUP, 2022.
  14. Andreia Marinho; Catarina Leal Seabra; Lima, Sofia; Claudia Nunes; Reis, Salette. "Anti-inflammatory effect of naringin delivered in lipid nanoparticles". Paper presented in NALS-Nanomaterials Applied to Life Sciences 2022, 2022.
  15. "Essential oil-enriched marine hydrogels for stratum corneum permeation enhancement". Paper presented in ChemBioGels 2021, 2021.
  16. "Topical delivery of niacinamide to skin using hybrid nanogels enhances photoprotection effect". Paper presented in ChemBioGels 2021, 2021.
  17. "Nutritive value and palatability of microalgae species in dog feeding". Paper presented in EAAP Annual Meeting 2021, 2021.
  18. "Synthesis of sugar-coated marine polymeric nanosystems for topical delivery of bioactive agents". Paper presented in 14th IJUP, 2021.
  19. Suellen Morais; Costa Lima, S A; Salette Reis; Claudia Nunes; Célia Sousa. "Iron-based Nanostructures Encapsulated in Lipid Nanoparticles as a Multifunctional Nanocarriers for doxorubicin controlled delivery". Paper presented in NALS 2020 - Nanomaterials Applied to Life Sciences, 2020.
  20. Tânia Moniz; Sedef Kaplan; Lima, Sofia; Salette Reis. "Chemical characterization of the PVPAsc model: the effect of surfactants and different pH on barrier permeability". Paper presented in Skin & Formulation Network, 2019.
  21. Simone Stefani; Ana Isabel Barbosa; Tânia Moniz; Sofia A. Costa Lima; Salette Reis. "Optimization of a nanoformulation for skin delivery: the influence of structure and composition". Paper presented in Skin & Formulation Network, 2019.
    10.1109/cise.2009.5365231
  22. Maria Inês Silva; Ana Isabel Barbosa; Lima, Sofia; Salette Reis. "A nanotechnological approach for the topical delivery of cyclosporine A". Paper presented in Skin & Formulation Network, Bath, 2019.
  23. Tânia Moniz; Simone Stefani; Ana Isabel Barbosa; Lima, Sofia; Salette Reis. "In vitro skin models: a novel lipid-based human stratum corneum mimetic model for the optimization of skin drug formulations". Paper presented in Skin Forum, Reims, 2019.
  24. Diana Araújo; Vitor Alves; Lima, Sofia; Filomena Freitas; Elvira Fortunato; Maria A. M. Reis. "Transdermal delivery systems based on natural polymeric biomaterials". Paper presented in Ciencia 2019, 2019.
  25. Ana Isabel Barbosa; Lima, Sofia; Salette Reis. "In vitro skin cellular model: a tool to unravel transport mechanisms and bioavailability". Paper presented in Advanced Summer School – Interrogations at the Biointerface, 2019.
  26. João Campos; Domingos Ferreira; Lima, Sofia; Salette Reis; Paulo Costa. "Local budesonide delivery using polymeric nanoparticles for oral mucositis management". Paper presented in 6th Nano Today Conference, 2019.
  27. Lima, Sofia; Ana Isabel Barbosa; Tânia Moniz; Cláudia Nunes; Salette Reis. "A novel human stratum corneum mimetic model, as a tool in the optimization of skin drug formulations". Paper presented in ETPN / NanoMed Europe, 2019.
  28. Mariana Romanholo; Ana Isabel Barbosa; Diana Resende; Lima, Sofia; Emília Sousa; Madalena Pinto; Salette Reis. "Marine nature as a source for cancer therapy: xanthone loaded fucoidan/chitosan nanoparticles". Paper presented in 12th IJUP, 2019.
  29. João Campos; Domingos Ferreira; Lima, Sofia; Salette Reis; Paulo Costa. "Development of budesonide polymeric mucoadhesive particles for the local management of oral mucositis". Paper presented in SPLC-CRS Santiago Compostela, 2019.
  30. Sara Marques; Inês Ramos; Sara Fernandes; Luísa Barreiros; Lima, Sofia; Salette Reis; Maria Domingues; Marcela A. Segundo. "Exploiting ultrafiltration for purification and characterization of drug-nanocarriers". Paper presented in Euroanalysis 2019, 2019.
  31. Zinaide Shakel; Claudia Nunes; Lima, Sofia; Salette Reis. "In Vitro Skin Models As A Tool In The Optimization Of Drug Formulation.". Paper presented in SFNano 2018, Montepellier, 2018.
  32. Sara Marques; Inês Ramos; Luísa Barreiros; Lima, Sofia; Salette Reis; Maria R. Domingues; Marcela A. Segundo. "Immunopurification of nanoparticles under lab-on-valve format Immunopurification of nanoparticles under lab-on-valve format.". Paper presented in Flow Analysis and Capillary Electrophoresis, Hradec Kralove, 2018.
  33. Sara Marques; Inês Ramos; Luísa Barreiros; Lima, Sofia; Salette Reis; Maria R. Domingues; Marcela A. Segundo. "Evaluation of encapsulation efficiency in methotrexate-loaded nanoparticles using separative methods". Paper presented in Analita 2018: 9th Meeting of the Analytical Chemistry Division, 2018.
  34. Sândia Machado; Sara Fernandes; Luíse Chaves; Sofia A. Costa Lima; Eduarda Silva; Luísa Barreiros; Salette Reis; Marcela A. Segundo. "Simultaneous determination of Dapsone and Clofazimine in nanoformulations by HPLC". Paper presented in Analita 2018: 9th Meeting of the Analytical Chemistry Division, 2018.
    10.1109/rsete.2011.5966191
  35. Joana Cardoso; Ana Isabel Barbosa; Lima, Sofia; Salette Reis. "Fucoidan/ Chitosan nanoparticles: the influence of type and amount of polysaccharides". Paper presented in 11st IJUP, 2018.
  36. Daniela Lopes-de-Campos; Rita M. Pinto; Catarina Seabra; Lima, Sofia; Cristina Martins; Cláudia Nunes; Salette Reis. "Amoxicillin-loaded lipid nanoparticles: towards a therapeutic approach for Helicobacter pylori infections". Paper presented in NanoBio&Med2017, 2017.
  37. Miguel Horta; Rita Leal; Lima, Sofia; Célia Sousa; J. P. Araújo; Salette Reis; Cláudia Nunes. "Paclitaxel loaded hybrid magnetic-lipid nanoparticles as a novel approach for cancer therapy". Paper presented in 1st BioBrillouin Meeting, 2017.
  38. Lima, Sofia; Salette Reis. "Co-delivery of gold nanoparticles and methotrexate in polymeric nanospheres for photothermal therapy". Paper presented in 1st BioBrillouin Meeting, 2017.
  39. Joana Cardoso; Ana Isabel Barbosa; Lima, Sofia; Salette Reis. "Development and characterization of Fucoidan/ Chitosan pH sensitive nanoparticles". Paper presented in 10th IJUP, 2017.
  40. Beatriz Costa; A. S. Gaspar; P. H. C. Santos; F. E. Wagner; Lima, Sofia; O. B. Ribeiro; L. Durães. "Development of biocompabible magnetic nanofluids for biomedical applications". Paper presented in 2nd International Conference on “Multifunctional Materials and their Applications”, 2017.
  41. Ana Isabel Barbosa; Lima, Sofia; Carlos Afonso; Salette Reis. "Optimization and characterization Chitosan/Fucoidan pH sensitive nanoparticles for delivery of methotrexate". Paper presented in XXII Encontro Luso-Galego de Química, 2016.
  42. Liliana Pereira; M. M. Cruz; M. L. Oliveira; S. G. Mendo; A. F. Alves; Salette Reis; Lima, Sofia; M. Godinho; M. D. Carvalho. "Decorated nanoparticles of magnetic hyperthermia.". Paper presented in 11th Inorganic Chemistry Conference, Portuguese Society of Chemistry, 2016.
  43. Luíse L. Chaves; Alexandre Vieira; Lima, Sofia; Domingos Ferreira; Bruno Sarmento; Salette Reis. "Solid lipid nanoparticles as strategy to improve clofazimine intestinal absorption: design, characterization and in vitro cytotoxicity studies". Paper presented in 7th International Congress Nanotechnology in Biology & Medicine - BioNanoMed, 2016.
  44. Lima, Sofia; Salette Reis. "Magnetic nanoparticle – cancer cell interactions: noninvasive assessment". Paper presented in RADIOMAG Annual Meeting, 2015.
  45. A. S. Gaspar; F. E. Wagner; V. S. Amaral; Lima, Sofia; J.G. Santos; B. F. O. Costa; L. Durães. "Development of a magnetic nanofluid by incorporating SPIONs in Amazonian oils". Paper presented in XXXIX CSI, 2015.
  46. P. Tibaldo; L. L. Chaves; Lima, Sofia; Salette Reis. "Optimization and characterization of methotrexate-loaded polymeric nanoparticles: a Box-Behnken design approach". Paper presented in 8th IJUP 2015, 2015.
  47. Mara Ferreira; Lima, Sofia; Salette Reis. "Optimization and characterization of lipid-based nanoparticles for topical therapy of psoriasis". Paper presented in NanoPT 2015, 2015.
  48. Mara Ferreira; Lima, Sofia; Salette Reis. "Optimization and development of nanostructure lipid carriers for topical therapy of psoriasis". Paper presented in Luso Galego 2014, 2014.
  49. Lima, Sofia; Salette Reis. "Theranostic nanospheres for localized photothermal therapy of Rheumatoid Arthritis.". Paper presented in ETP-Nanomedicine Annual Meeting 2014, 2014.
  50. Daniela Barros; Lima, Sofia; Anabela Cordeiro-da-Silva. "Surface functionalization of polymeric nanospheres modulates macrophage activation – application in visceral leishmaniasis therapy". Paper presented in Bioimaging 2014, 2014.
  51. Maria Pinto; Lima, Sofia; Salette Reis. "Methotrexate-loaded NLCs for psoriasis topical therapy: optimization, production and characterization". Paper presented in ANM 2014, 2014.
  52. Lima, Sofia; Salette Reis. "Methotrexate-loaded polymeric nanospheres containing Gold nanoparticles for localized photothermal therapy of Rheumatoid Arthritis". Paper presented in NanoBio-Europe, 2014.
  53. Lima, Sofia; Salette Reis. "Quantification of methotrexate released from drug delivery systems". Paper presented in Simpósio SPQ-Analítica 2014, 2014.
  54. Lima, Sofia; M. T. Baltazar; R. J. Dinis-Oliveira; Anabela Cordeiro-da-Silva. "Therapeutic efficacy and safety of BNIPDaoct-loaded PLGA nanoparticles for the treatment of visceral leishmaniasis". Paper presented in 7th IJUP 2014, 2014.
  55. Lima, Sofia; Salette Reis. "Preparation and characterization of polymeric nanospheres for rheumatoid arthritis treatment.". Paper presented in NanofolNanodiara Meeting - Nanoparticles for early Diagnostics of inflammatory diseases, 2013.
  56. A. R. Neves; Lima, Sofia; J. L. C. Lima; Salette Reis. "Nanoimaging of resveratrol-loaded lipid nanoparticles during caco-2 cell uptake". Paper presented in International Symposium in Applied Bioimaging 2013, 2013.
  57. M. V. Osório; S. Nogueira; Marcela A. Segundo; V. L. R. G. Abreu; Anabela Cordeiro-da-Silva; Lima, Sofia. "Assessment of an anti-Leishmania compound loaded on PLGA nanoparticles - in vitro and in vivo studies". Paper presented in 6th IJUP 2013, 2013.
  58. S. Nogueira; D. Barros; Anabela Cordeiro-da-Silva; Lima, Sofia. "Unraveling the mechanism of action of BNIPDiaminooctane on Leishmania infantum parasites – target identification and development of resistant strain.". Paper presented in 6th IJUP 2013, 2013.
  59. Daniela Barros; Anabela Cordeiro-da-Silva; Lima, Sofia. "Immunotherapeutic potential of mannosylated nanoparticles". Paper presented in XXXVIII Annual Meeting of the Portuguese Society of Immunology, 2012.
  60. M. Ouaissi; F. Silvy; Lima, Sofia; B. Sastre; I. Sielezneff; Anabela Cordeiro-da-Silva; D. Lombardo; E. Mas; A. Ouaissi. "HDAC gene expression in pancreatic tumor cell lines submitted to the probinostat or trichostatin HDAC Inhibitors". Paper presented in ESSR 2012 47th Annual Congress, 2012.
  61. Daniela Barros; Anabela Cordeiro-da-Silva; Lima, Sofia. "Mannosylated nanoparticles for targeted delivery of amphotericin B towards visceral leishmaniasis". Paper presented in 3rd I3S scientific meeting, 2012.
  62. Patrícia Varela; P. K. T. Lin; Lima, Sofia; Anabela Cordeiro-da-Silva. "Drug screening of bisnaphthalimidopropyl derivatives on Trypanosoma brucei.". Paper presented in 3rd I3S scientific meeting, 2012.
  63. Daniela Barros; Anabela Cordeiro-da-Silva; Lima, Sofia. "Active targeting of macrophages by mannosylated nanoparticles loaded with amphotericin B towards visceral leishmaniasis therapy.". Paper presented in Colloids and Nanomedicine, 2012.
  64. Patrícia Varela; P. K. T. Lin; Anabela Cordeiro-da-Silva; Lima, Sofia. "In vitro screening of bisnaphthalimidopropyl derivatives on Trypanosoma brucei". Paper presented in British Society for Parasitology Spring Meeting 2012, 2012.
  65. M. Ouaissi; F. Silvy; Lima, Sofia; B. Sastre; I. Sielezneff; Anabela Cordeiro-da-Silva; D. Lombardo; E. Mas; A. Ouaissi. "Etude de l'efficacité panobinostat LBH 589 sur l’inhibition de la croissance des lignées cellulaires cancéreuses pancréatiques et la corrélation au niveau d’expression des HDAC". Paper presented in Journees Francophones d’Hepato-gastroenterologie et d’Oncologie Digestive 2012, 2012.
  66. Patrícia Varela; P. K. T. Lin; Anabela Cordeiro-da-Silva; Lima, Sofia. "Drug screening of bisnaphthalimidopropyl derivatives on Trypanosoma brucei". Paper presented in 5th IJUP’12, 2012.
  67. Daniela Barros; Lima, Sofia; Anabela Cordeiro-da-Silva. "Development and optimisation of targeted drug delivery systems towards visceral leishmaniasis". Paper presented in 5th IJUP’12, 2012.
  68. M. V. Osório; S. Nogueira; Marcela A. Segundo; V. L. R. G. Abreu; Anabela Cordeiro-da-Silva; Lima, Sofia. "Evaluation of anti-Leishmania compound released from polymeric nanoparticles". Paper presented in 5th IJUP’12, 2012.
  69. Marcela A. Segundo; V. L. R. G. Abreu; M. V. Osório; S. Nogueira; Anabela Cordeiro-da-Silva; Lima, Sofia. "Fluorimetric determination of bisnaphthalimidopropyldiaaminooctane by liquid chromatography using a monolithic column". Paper presented in 7º Encontro Nacional de Cromatografia, 2012.
  70. A. L. Robalo; J. A. Pereira; M. Resende; D, Moreira; J. Cunha; Lima, Sofia; Anabela Cordeiro-da-Silva. "Activation of IL-27p28 gene transcription on antigen presenting cells infected with Leishmania infantum". Paper presented in XXXVII SPI Annual Meeting, 2011.
  71. M. Ouaissi; F. Sylvi; Lima, Sofia; B. Sastre; I. Sielezneff; Anabela Cordeiro-da-Silva; E. Mas; A. Ouaissi. "Characterization of the anti-pancreatic tumor cell effect induced by LBH589 and its relation to HDAC encoding genes expression". Paper presented in Porto Cancer Meeting, 2011.
  72. K. Prousis; M. Roussaki; B. Hall; S. Wilkinson; Lima, Sofia; Anabela Cordeiro-da-Silva. "Novel antiparasitic agents based on the quinolinone heterocyclic scaffold". Paper presented in COST annual meeting, 2011.
  73. Lima, Sofia; V. Rodrigues; J. Garrido; F. Borges; P. K. T. Lin; Anabela Cordeiro-da-Silva. "Pegylated nanoparticles for encapsulation of bisnaphthalimidopropyl derivatives against Leishmania infantum". Paper presented in Trends in Nanotechnology, 2010.
  74. Lima, Sofia; M. Roussaki; S. Sampaio; A. Detsi; Anabela Cordeiro-da-Silva. "Determinação da actividade anti-Leishmania de compostos heterocíclicos por citometria de fluxo". Paper presented in XIV Congresso Português de Parasitologia, 2010.
  75. M. Roussaki; K. Prousis; Lima, Sofia; Anabela Cordeiro-da-Silva; A. Detsi. "Natural Product Analogues with anti - Leishmania infantum activity". Paper presented in 14th Hellenic Symposium on Medicinal Chemistry, 2010.
  76. S. Sampaio; Lima, Sofia; A. Detsi; Anabela Cordeiro-da-Silva. "Bioactivity of flavonoids against Leishmania infantum determined by flow cytometry". Paper presented in 3º Encontro de Jovens Investigadores da Universidade do Porto, 2010.
  77. Lima, Sofia; P. K. T. Lin; Anabela Cordeiro-da-Silva. "In vitro evaluation of bisnaphthalimidopropyl-derivatives loaded PLGA nanoparticles on Leishmania infected cells". Paper presented in 18th Conference on Inorganic Chemistry, 2009.
  78. Lima, Sofia; P. K. T. Lin. "Encapsulation of bisnaphthalimidopropyl derivatives, two novel anti-Leishmania drugs, in biodegradable PLA and PLGA nanoparticles". Paper presented in Nanomedicine 2008, 2008.
  79. R. Silva; Anabela Cordeiro-da-Silva; Lima, Sofia; F. Carvalho; M. L. Bastos; H. Carmo; F. Remião. "Effect of P-Glycoprotein inducers on its expression and activity in Caco-2 cells". Paper presented in 45th Eurotox Congress, 2008.
  80. Lima, Sofia; Anabela Cordeiro-da-Silva; B. de Castro; P. Gameiro. "Citometria de fluxo: um método para quantificar e identificar inibidores da P-glicoproteína". Paper presented in 6º Encontro Nacional de Química Analítica, 2006.
  81. Lima, Sofia; Anabela Cordeiro-da-Silva; B. de Castro; P. Gameiro. "Conformational changes of P-glycoprotein induced by drug - and nucleotide- binding". Paper presented in 4º Encontro do REQUIMTE, 2006.
  82. Lima, Sofia; Anabela Cordeiro-da-Silva; B. de Castro; P. Gameiro. "Intrinsic fluorescence of membrane transport proteins – sensitivity of Trp residues to binding of drugs". Paper presented in 1st European Conference on Chemistry for Life Sciences, 2005.
  83. Lima, Sofia; Anabela Cordeiro-da-Silva; B. de Castro; P. Gameiro. "A Resonance Energy Transfer study of the Rifampicin and RifampicinSV interaction with the multidrug transporter P-glycoprotein". Paper presented in 3rd Portuguese-Spanish Biophysics Congress, 2004.
  84. Lima, Sofia; Anabela Cordeiro-da-Silva; P. Gameiro; B. de Castro. "Intrinsic tryptophan fluorescence study of the interaction of benzodiazepines with P-glycoprotein.". Paper presented in Transporters 2004 – International Symposium on Membrane Transport and Transporters, 2004.
  85. Lima, Sofia; Anabela Cordeiro-da-Silva; P. Gameiro; B. de Castro. "Evaluation of the structure and function of the reconstituted P-glycoprotein multidrug transporter". Paper presented in 3º Encontro do REQUIMTE, 2004.
  86. Lima, Sofia; Anabela Cordeiro-da-Silva; P. Gameiro; B. de Castro. "Determinação do coeficiente de partição rifampicina/lipossomas por espectrofotometria derivative". Paper presented in 3º Encontro Nacional de Química Analítica, Escola Superior e Biotecnologia da Universidade Católica Portuguesa, 2003.
  87. Sofia A. Costa Lima; Forgac, Michael; P. Gameiro; B. de Castro. "Reconstitution of ATPase activity in proteoliposomes of mouse MDR3 P-glycoprotein.". Paper presented in XVII European Colloid and Interface Society Conference, 2003.
    10.1158/1535-7163.targ-15-a124
  88. Lima, Sofia; Anabela Cordeiro-da-Silva; P. Gameiro; B. de Castro. "Purificação da P-glicoproteína (MDR3) funcional a partir de células de Pichia pastoris". Paper presented in 1º Congresso da Sociedade Portuguesa de Ciências Farmacêuticas, 2003.
  89. Lima, Sofia; P. M. L. Castro; R. M. Morais. "Degradation of and p-nitrophenol by a cyanobacteria consortium". Paper presented in 10th European Congress in Biotechnology, 2001.
  90. Lima, Sofia; R. H. Pires; F. Tavaria; F. X. Malcata. "Characterisation of bacterial isolates from Serra da Estrela Cheese via analysis of their electrophoretic protein profiles.". Paper presented in BIOTEC'98 – IV Congresso Ibérico de Biotecnologia e I Encontro Ibero-Americano de Biotecnologia, 1998.
Edited book
  1. Adriano Bordalo e Sá; Begoña Pérez-Cabezas; Azevedo, Luísa; Costa Lima, Sofia A.. One Health – Uma Saúde Um contributo da Universidade. Porto: UP Press. 2024.
    Published • Editor
Journal article
  1. Ricardo Magalhães; Claudia Nunes; Sofia A. Costa Lima; David Navas; Carolina Redondo; Rafael Morales; Miriam Jaafar; Célia Tavares de Sousa. "Vortex Nanodiscs Functionalization to Overcome Macrophage Recognition for Efficient Theragnosis Applications". Advanced Engineering Materials (2024): https://doi.org/10.1002/adem.202400369.
    10.1002/adem.202400369
  2. Francisco Faísca; Željko Petrovski; Inês Grilo; Sofia A. C. Lima; Miguel M. Santos; Luis C. Branco. "Synthesis, Characterization, Bioavailability and Antimicrobial Studies of Cefuroxime-Based Organic Salts and Ionic Liquids". Pharmaceutics (2024): https://doi.org/10.3390/pharmaceutics16101291.
    10.3390/pharmaceutics16101291
  3. Célia Marques; Liliana Grenho; Maria Helena Fernandes; Sofia A. Costa Lima. "Improving the Antimicrobial Potency of Berberine for Endodontic Canal Irrigation Using Polymeric Nanoparticles". Pharmaceutics (2024): https://doi.org/10.3390/pharmaceutics16060786.
    10.3390/pharmaceutics16060786
  4. Andreia Marinho; Catarina Leal Seabra; Sofia A. C. Lima; Alexandre Lobo-da-Cunha; Salette Reis; Cláudia Nunes. "Empowering Naringin’s Anti-Inflammatory Effects through Nanoencapsulation". International Journal of Molecular Sciences (2024): https://doi.org/10.3390/ijms25084152.
    10.3390/ijms25084152
  5. Joana Guilherme-Fernandes; Tiago Aires; António J. M. Fonseca; Timur Yergaliyev; Amélia Camarinha-Silva; Costa Lima, S A; Margarida R. G. Maia; Ana R. J. Cabrita. "Squid meal and shrimp hydrolysate as novel protein sources for dog food". Frontiers in Veterinary Science 11 (2024):
    Open access • 10.3389/fvets.2024.1360939
  6. Joana Guilherme-Fernandes; António J. M. Fonseca; Tiago Aires; Costa Lima, Sofia A.; Maia, Margarida R. G.; Ana R. J. Cabrita. "Unveiling the effects of shrimp hydrolysate as a dietary ingredient in healthy adult Beagle dogs". Journal of Animal Science 102 (2024): skae280. https://pubmed.ncbi.nlm.nih.gov/39292957/.
    Accepted • 10.1093/jas/skae280
  7. Shakel, Zinaida; Costa Lima, S A; Salette Reis. "Strategies to make human skin models based on cellular senescence for ageing research". Ageing Res Rev. 100 (2024): 102430..
    Accepted
  8. Kristina Radic; Ana Isabel Barbosa; Salette Reis; Marijan Marijan; Sofia Antunes Costa Lima; Dubravka Vitali Cepo. "Preparation of astaxanthin/zeaxanthin-loaded nanostructured lipid carriers for enhanced bioavailability: Characterization-, stability-and permeability study". Acta Pharmaceutica (2023): https://doi.org/10.2478/acph-2023-0038.
    10.2478/acph-2023-0038
  9. Katerina Spanou; Ana Isabel Barbosa; Anastasia Detsi; Sofia A. Costa Lima; Salette Reis. "Development and characterization of gel-like matrix containing genistein for skin application". Journal of Drug Delivery Science and Technology (2023): https://doi.org/10.1016/j.jddst.2023.105119.
    10.1016/j.jddst.2023.105119
  10. Célia Marques; Maria Helena Fernandes; Sofia A. Costa Lima. "Elucidating Berberine's Therapeutic and Photosensitizer Potential through Nanomedicine Tools". Pharmaceutics (2023): https://doi.org/10.3390/pharmaceutics15092282.
    10.3390/pharmaceutics15092282
  11. Filipa Serrasqueiro; Ana Isabel Barbosa; Sofia A. Costa Lima; Salette Reis. "Targeting the Mannose Receptor with Functionalized Fucoidan/Chitosan Nanoparticles Triggers the Classical Activation of Macrophages". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24129908.
    10.3390/ijms24129908
  12. Costa Lima, S A. "Rational design of magnetoliposomes for enhanced interaction with bacterial membrane models". Biochimica et Biophysica Acta (BBA) - Biomembranes 1865 (2023): 184115.
    10.1016/j.bbamem.2022.184115
  13. Barbosa, Ana Isabel; Lima, Sofia A. Costa; Yousef, Ibraheem; Reis, Salette. "Evaluating the Skin Interactions and Permeation of Alginate/Fucoidan Hydrogels Per Se and Associated with Different Essential Oils". Pharmaceutics 15 1 (2023): 190. http://dx.doi.org/10.3390/pharmaceutics15010190.
    10.3390/pharmaceutics15010190
  14. Sarah A. P. Pereira; Jan Romano-deGea; Ana Isabel Barbosa; Costa Lima, S A; Paul J. Dyson; M. Lúcia M. F. S. Saraiva. "Fine-tuning the cytotoxicity of ruthenium(ii) arene compounds to enhance selectivity against breast cancers". Dalton Transactions 52 (2023): 11679-11690. doi: 10.1039/d3dt02037a.
    Open access • 10.1039/d3dt02037a
  15. Costa Lima, S A; Ana Isabel, Barbosa; Cláudia, Nunes; Ibraheem, Yousef; Salette, Reis. Corresponding author: Costa Lima, S A. "Synchrotron-based infrared microspectroscopy of polymeric nanoparticles and skin: Unveiling molecular interactions to enhance permeation". Chemistry and Physics of Lipids 249 (2022): 105254.
    Open access • 10.1016/j.chemphyslip.2022.105254
  16. A. R. J. Cabrita; Joana Fernandes; Inês Maria Valente; Agostinho Almeida; Sofia A. Costa Lima; AJM Fonseca; M.R.G. Maia. "Nutritional Composition and Untargeted Metabolomics Reveal the Potential of Tetradesmus obliquus, Chlorella vulgaris and Nannochloropsis oceanica as Valuable Nutrient Sources for Dogs". Animals (2022): https://www.mdpi.com/2076-2615/12/19/2643.
    10.3390/ani12192643
  17. Tânia M. T. Guimarães; Tânia Moniz; Cláudia Nunes; Maya Margaritova Zaharieva; Mila Kaleva; Krassimira Yoncheva; Hristo Najdenski; Sofia A. Costa Lima; Salette Reis. "Polymeric Microneedles for Transdermal Delivery of Rivastigmine: Design and Application in Skin Mimetic Model". Pharmaceutics 14 4 (2022): 752-752. https://doi.org/10.3390/pharmaceutics14040752.
    10.3390/pharmaceutics14040752
  18. Adouni, Khaoula; Júlio, Ana; Santos-Buelga, Celestino; González-Paramás, Ana M.; Filipe, Patrícia; Rijo, Patricia; Costa Lima, Sofia A.; et al. "Roots and rhizomes of wild Asparagus: Nutritional composition, bioactivity and nanoencapsulation of the most potent extract". Food Bioscience 45 (2022): 101334. http://dx.doi.org/10.1016/j.fbio.2021.101334.
    Published • 10.1016/j.fbio.2021.101334
  19. Renata Basto; Raquel Andrade; Cláudia Nunes; Sofia A. Costa Lima; Salette Reis. "Topical Delivery of Niacinamide to Skin Using Hybrid Nanogels Enhances Photoprotection Effect". Pharmaceutics 13 11 (2021): 1968-1968. https://doi.org/10.3390/pharmaceutics13111968.
    10.3390/pharmaceutics13111968
  20. Tânia Moniz; Sofia A. Costa Lima; Salette Reis. "Protocol for the Isolation of Stratum Corneum from Pig Ear Skin: Evaluation of the Trypsin Digestion Conditions". Methods and Protocols (2021): https://doi.org/10.3390/mps4040080.
    10.3390/mps4040080
  21. Fonseca, Magda; Macedo, Ana S.; Lima, Sofia A. Costa; Reis, Salette; Soares, Raquel; Fonte, Pedro. "Evaluation of the Antitumour and Antiproliferative Effect of Xanthohumol-Loaded PLGA Nanoparticles on Melanoma". Materials 14 21 (2021): 6421. http://dx.doi.org/10.3390/ma14216421.
    Published • 10.3390/ma14216421
  22. Rita M. Pinto; Claudia Monteiro; Sofia A. Costa Lima; Susana Casal; Patrick Van Dijck; M. Cristina L. Martins; Cláudia Nunes; Salette Reis. "N-Acetyl-l-cysteine-Loaded Nanosystems as a Promising Therapeutic Approach Toward the Eradication of Pseudomonas aeruginosa Biofilms". ACS Applied Materials & Interfaces (2021): https://doi.org/10.1021/acsami.1c05124.
    10.1021/acsami.1c05124
  23. Raquel Costa; Sofia A. Costa Lima; Paula Gameiro; Salette Reis. "On the Development of a Cutaneous Flavonoid Delivery System: Advances and Limitations". Antioxidants 10 9 (2021): 1376-1376. https://doi.org/10.3390/antiox10091376.
    10.3390/antiox10091376
  24. Joana Costa Antunes; Catarina Leal Seabra; Joana Margarida Domingues; Marta Oliveira Teixeira; Cláudia Nunes; Sofia Antunes Costa-Lima; Natália Cândido Homem; et al. "Drug Targeting of Inflammatory Bowel Diseases by Biomolecules". Nanomaterials 11 8 (2021): 2035-2035. https://doi.org/10.3390/nano11082035.
    10.3390/nano11082035
  25. Moniz, Tânia; Costa Lima, Sofia A.; Reis, Salette. "Marine polymeric microneedles for transdermal drug delivery". Carbohydrate Polymers 266 (2021): 118098. http://dx.doi.org/10.1016/j.carbpol.2021.118098.
    Published • 10.1016/j.carbpol.2021.118098
  26. Ana Isabel Barbosa; Tiago Torres; Sofia A. Costa Lima; Salette Reis. "Hydrogels: A Promising Vehicle for the Topical Management of Atopic Dermatitis". Advanced Therapeutics (2021): https://doi.org/10.1002/adtp.202100028.
    10.1002/adtp.202100028
  27. Sofia A. Costa Lima; Salette Reis. "Polymeric Carriers for Biomedical and Nanomedicine Application". Polymers 13 8 (2021): 1261-1261. https://doi.org/10.3390/polym13081261.
    10.3390/polym13081261
  28. Célia T. Sousa; A. Marinho; Andreia Granja; Cláudia Nunes; João P. Araújo; Costa Lima, S A; S. Moraes; Salette Reis. "Targeted nanostructured lipid carriers for doxorubicin oral delivery". International Journal of Pharmaceutics 592 (2021): 120029.
    10.1016/j.ijpharm.2020.120029
  29. Vieira, Alexandre C.C.; Chaves, Luíse L.; Pinheiro, Marina; Lima, Sofia Costa; Neto, Pedro José Rolim; Ferreira, Domingos; Sarmento, Bruno; Reis, Salette. "Lipid nanoparticles coated with chitosan using a one-step association method to target rifampicin to alveolar macrophages". Carbohydrate Polymers 252 (2021): 116978. http://dx.doi.org/10.1016/j.carbpol.2020.116978.
    Accepted • 10.1016/j.carbpol.2020.116978
  30. Moraes, S.; Marinho, A.; Lima, S.; Granja, A.; Araújo, J.P.; Reis, S.; Sousa, C.T.; Nunes, C.. "Targeted nanostructured lipid carriers for doxorubicin oral delivery". International Journal of Pharmaceutics 592 (2021): 120029. http://dx.doi.org/10.1016/j.ijpharm.2020.120029.
    Published • 10.1016/j.ijpharm.2020.120029
  31. Raquel G. D. Andrade; Bruno Reis; Benjamin Costas; Sofia A. Costa Lima; Salette Reis. "Modulation of Macrophages M1/M2 Polarization Using Carbohydrate-Functionalized Polymeric Nanoparticles". Polymers 13 1 (2020): 88-88. https://doi.org/10.3390/polym13010088.
    10.3390/polym13010088
  32. Luíse L. Chaves; Yuri Patriota; José L. Soares-Sobrinho; Alexandre C. C. Vieira; Sofia A. Costa Lima; Salette Reis. "Drug Delivery Systems on Leprosy Therapy: Moving Towards Eradication?". Pharmaceutics (2020): https://doi.org/10.3390/pharmaceutics12121202.
    10.3390/pharmaceutics12121202
  33. Moniz, Tânia; Costa Lima, Sofia A.; Reis, Salette. "Application of the human stratum corneum lipid-based mimetic model in assessment of drug-loaded nanoparticles for skin administration". International Journal of Pharmaceutics 591 (2020): 119960. http://dx.doi.org/10.1016/j.ijpharm.2020.119960.
    Published • 10.1016/j.ijpharm.2020.119960
  34. Ludovico Esposito; Ana Isabel Barbosa; Tânia Moniz; Sofia Costa Lima; Paulo Costa; Christian Celia; Salette Reis. "Design and Characterization of Sodium Alginate and Poly(vinyl) Alcohol Hydrogels for Enhanced Skin Delivery of Quercetin". Pharmaceutics (2020): https://doi.org/10.3390/pharmaceutics12121149.
    10.3390/pharmaceutics12121149
  35. Ong, Yong Sze; Bañobre-López, Manuel; Costa Lima, Sofia A.; Reis, Salette. "A multifunctional nanomedicine platform for co-delivery of methotrexate and mild hyperthermia towards breast cancer therapy". Materials Science and Engineering: C 116 (2020): 111255. http://dx.doi.org/10.1016/j.msec.2020.111255.
    10.1016/j.msec.2020.111255
  36. Daniela Resende; Sofia A. Costa Lima; Salette Reis. "Nanoencapsulation approaches for oral delivery of vitamin A". Colloids and Surfaces B: Biointerfaces (2020): 111121-111121. https://doi.org/10.1016/j.colsurfb.2020.111121.
    10.1016/j.colsurfb.2020.111121
  37. Moniz, Tânia; Costa Lima, Sofia A.; Reis, Salette. "Human skin models: From healthy to disease-mimetic systems; characteristics and applications". British Journal of Pharmacology (2020): http://dx.doi.org/10.1111/bph.15184.
    10.1111/bph.15184
  38. Oliver, Miquel; Kudlak, Blazej; Wieczerzak, Monika; Reis, Salette; Lima, Sofia A.C.; Segundo, Marcela A.; Miró, Manuel. "Ecotoxicological equilibria of triclosan in Microtox, XenoScreen YES/YAS, Caco2, HEPG2 and liposomal systems are affected by the occurrence of other pharmaceutical and personal care emerging contaminants". Science of The Total Environment 719 (2020): 137358. http://dx.doi.org/10.1016/j.scitotenv.2020.137358.
    10.1016/j.scitotenv.2020.137358
  39. Maria Inês Silva; Ana Isabel Barbosa; Sofia A. Costa Lima; Paulo Costa; Tiago Torres; Salette Reis; Silva, Maria Inês; et al. "Freeze-Dried Softisan® 649-Based Lipid Nanoparticles for Enhanced Skin Delivery of Cyclosporine A". Nanomaterials 10 5 (2020): 986-986. https://doi.org/10.3390/nano10050986.
    10.3390/nano10050986
  40. Marques, Sara S.; Ramos, Inês I.; Fernandes, Sara R.; Barreiros, Luisa; Lima, Sofia A. C.; Reis, Salette; Domingues, M. Rosário M.; Segundo, Marcela A.. "Insights on Ultrafiltration-Based Separation for the Purification and Quantification of Methotrexate in Nanocarriers". Molecules 25 8 (2020): 1879. http://dx.doi.org/10.3390/molecules25081879.
    10.3390/molecules25081879
  41. Coutinho, A.J.; Costa Lima, S.A.; Afonso, C.M.M.; Reis, S.. "Mucoadhesive and pH responsive fucoidan-chitosan nanoparticles for the oral delivery of methotrexate". International Journal of Biological Macromolecules 158 (2020): 180-188. http://www.scopus.com/inward/record.url?eid=2-s2.0-85084220190&partnerID=MN8TOARS.
    10.1016/j.ijbiomac.2020.04.233
  42. Ana Isabel Barbosa; Ana Joyce Coutinho; Sofia A. Costa Lima (corresponding author); Salette Reis. "Marine Polysaccharides in Pharmaceutical Applications: Fucoidan and Chitosan as Key Players in the Drug Delivery Match Field". Marine Drugs 17 12 (2019): 654-654. https://doi.org/10.3390/md17120654.
    Published • 10.3390/md17120654
  43. Shakel, Zinaida; Nunes, Cláudia; Reis, Salette. "Development of a novel human stratum corneum model, as a tool in the optimization of drug formulations". International Journal of Pharmaceutics 569 (2019): 118571. http://dx.doi.org/10.1016/j.ijpharm.2019.118571.
    Published • 10.1016/j.ijpharm.2019.118571
  44. Abderrazzaq Essaghraoui; Ahmed Belfkira; Bassou Hamdaoui; Cláudia Nunes; Sofia A. Costa Lima (corresponding author); Salette Reis. "Improved Dermal Delivery of Cyclosporine A Loaded in Solid Lipid Nanoparticles". Nanomaterials (2019): https://doi.org/10.3390/nano9091204.
    10.3390/nano9091204
  45. João C. Campos; Domingos C. Ferreira; Sofia Lima; Salette Reis; Paulo J. Costa. "Swellable polymeric particles for the local delivery of budesonide in oral mucositis". International Journal of Pharmaceutics 566 (2019): 126-140. https://doi.org/10.1016/j.ijpharm.2019.05.057.
    10.1016/j.ijpharm.2019.05.057
  46. Ana Isabel Barbosa; Sofia A. Costa Lima (corresponding author); Salette Reis. "Development of methotrexate loaded fucoidan/chitosan nanoparticles with anti-inflammatory potential and enhanced skin permeation". International Journal of Biological Macromolecules (2019): https://doi.org/10.1016/j.ijbiomac.2018.12.014.
    10.1016/j.ijbiomac.2018.12.014
  47. Barbosa, A.I.; Costa Lima, S.A. (corresponding author); Reis, S.. "Application of pH-responsive fucoidan/chitosan nanoparticles to improve oral quercetin delivery". Molecules 24 2 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85060092617&partnerID=MN8TOARS.
    10.3390/molecules24020346
  48. Lopes-De-Campos, D.; Pinto, R.M.; Costa Lima, S.A.; Santos, T.; Sarmento, B.; Nunes, C.; Reis, S.. "Delivering amoxicillin at the infection site-a rational design through lipid nanoparticles". International Journal of Nanomedicine 14 (2019): 2781-2795. http://www.scopus.com/inward/record.url?eid=2-s2.0-85065589930&partnerID=MN8TOARS.
    10.2147/IJN.S193992
  49. Barbosa, A.I.; Fernandes, S.R.; Machado, S.; Sousa, P.; Sze, O.Y.; Silva, E.M.P.; Barreiros, L.; et al. "Fast monolith-based chromatographic method for determination of methotrexate in drug delivery studies". Microchemical Journal 148 (2019): 185-189. http://www.scopus.com/inward/record.url?eid=2-s2.0-85065077944&partnerID=MN8TOARS.
    10.1016/j.microc.2019.04.075
  50. Chaves, L.L.; Silveri, A.; Vieira, A.C.C.; Ferreira, D.; Cristiano, M.C.; Paolino, D.; Di Marzio, L.; et al. "pH-responsive chitosan based hydrogels affect the release of dapsone: Design, set-up, and physicochemical characterization". International Journal of Biological Macromolecules 133 (2019): 1268-1279. http://www.scopus.com/inward/record.url?eid=2-s2.0-85065421875&partnerID=MN8TOARS.
    10.1016/j.ijbiomac.2019.04.178
  51. Júlio, A.; Caparica, R.; Costa Lima, S.A.; Fernandes, A.S.; Rosado, C.; Prazeres, D.M.F.; Reis, S.; De Almeida, T.S.; Fonte, P.. "Ionic liquid-polymer nanoparticle hybrid systems as new tools to deliver poorly soluble drugs". Nanomaterials 9 8 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85074534554&partnerID=MN8TOARS.
    10.3390/nano9081148
  52. Júlio, A.; Costa Lima, S.A.; Reis, S.; Santos de Almeida, T.; Fonte, P.. "Development of ionic liquid-polymer nanoparticle hybrid systems for delivery of poorly soluble drugs". Journal of Drug Delivery Science and Technology (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85060944790&partnerID=MN8TOARS.
    10.1016/j.jddst.2019.01.030
  53. Araújo, D.; Alves, V.D.; Lima, S.A.C.; Reis, S.; Freitas, F.; Reis, M.A.M.. "Novel hydrogels based on yeast chitin-glucan complex: Characterization and safety assessment". International Journal of Biological Macromolecules (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85075984052&partnerID=MN8TOARS.
    10.1016/j.ijbiomac.2019.11.141
  54. Spirou SV; Costa Lima SA; Bouziotis P; Vranješ-Djuric S; Efthimiadou E¿; Laurenzana A; Barbosa AI; et al. "Recommendations for In Vitro and In Vivo Testing of Magnetic Nanoparticle Hyperthermia Combined with Radiation Therapy.". Nanomaterials (Basel, Switzerland) (2018): http://europepmc.org/abstract/med/29734795.
    10.3390/nano8050306
  55. Chaves LL; Costa Lima SA; Vieira ACC; Barreiros L; Segundo MA; Ferreira D; Sarmento B; Reis S. "Nanosystems as modulators of intestinal dapsone and clofazimine delivery.". Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (2018): http://europepmc.org/abstract/med/29864923.
    10.1016/j.biopha.2018.04.195
  56. Gouveia VM; Lopes-de-Araújo J; Costa Lima SA; Nunes C; Reis S. "Hyaluronic acid-conjugated pH-sensitive liposomes for targeted delivery of prednisolone on rheumatoid arthritis therapy.". Nanomedicine (London, England) (2018): http://europepmc.org/abstract/med/29790395.
    10.2217/nnm-2017-0377
  57. Alexandre C. C. Vieira; Luíse L. Chaves; Marina Pinheiro; Sofia A. Costa Lima; Domingos Ferreira; Bruno Sarmento; Salette Reis. "Mannosylated solid lipid nanoparticles for the selective delivery of rifampicin to macrophages". Artificial Cells, Nanomedicine, and Biotechnology (2018): https://doi.org/10.1080/21691401.2018.1434186.
    10.1080/21691401.2018.1434186
  58. Luíse L. Chaves; Sofia Lima; Alexandre C. C. Vieira; Domingos Ferreira; Bruno Sarmento; Salette Reis. "Overcoming clofazimine intrinsic toxicity: statistical modelling and characterization of solid lipid nanoparticles". Journal of The Royal Society Interface (2018): https://doi.org/10.1098/rsif.2017.0932.
    10.1098/rsif.2017.0932
  59. Moskvin, M.; Babic, M.; Reis, S.; Cruz, M.M.; Ferreira, L.P.; Carvalho, M.D.; Lima, S.A.C.; Horák, D.. "Biological evaluation of surface-modified magnetic nanoparticles as a platform for colon cancer cell theranostics". Colloids and Surfaces B: Biointerfaces 161 (2018): 35-41. http://www.scopus.com/inward/record.url?eid=2-s2.0-85032858139&partnerID=MN8TOARS.
    10.1016/j.colsurfb.2017.10.034
  60. Chaves, L.L.; Costa Lima, S.A.; Vieira, A.C.C.; Barreiros, L.; Segundo, M.A.; Ferreira, D.; Sarmento, B.; Reis, S.. "Development of PLGA nanoparticles loaded with clofazimine for oral delivery: Assessment of formulation variables and intestinal permeability". European Journal of Pharmaceutical Sciences 112 (2018): 28-37. http://www.scopus.com/inward/record.url?eid=2-s2.0-85033398806&partnerID=MN8TOARS.
    10.1016/j.ejps.2017.11.004
  61. Cavalcanti, S.M.T.; Nunes, C.; Costa Lima, S.A.; Soares-Sobrinho, J.L.; Reis, S.. "Optimization of nanostructured lipid carriers for Zidovudine delivery using a microwave-assisted production method". European Journal of Pharmaceutical Sciences 122 (2018): 22-30. http://www.scopus.com/inward/record.url?eid=2-s2.0-85048987574&partnerID=MN8TOARS.
    10.1016/j.ejps.2018.06.017
  62. Machado, S.; Fernandes, S.R.; Chaves, L.L.; Lima, S.A.C.; Silva, E.M.P.; Barreiros, L.; Reis, S.; Segundo, M.A.. "Chromatographic method for the simultaneous quantification of dapsone and clofazimine in nanoformulations". Journal of Separation Science 41 17 (2018): 3382-3388. http://www.scopus.com/inward/record.url?eid=2-s2.0-85051109733&partnerID=MN8TOARS.
    10.1002/jssc.201800427
  63. Lima, Sofia; Vieira, A.C.C.; Chaves, L.L.; Pinheiro, S.; Pinto, S.; Pinheiro, M.; Lima, S.C.; et al. "Mucoadhesive chitosan-coated solid lipid nanoparticles for better management of tuberculosis.". Int J Pharm. 536 1 (2017): 478-485. http://www.scopus.com/inward/record.url?eid=2-s2.0-85037993500&partnerID=MN8TOARS.
    doi: 10.1016/j.ijpharm.2017.11.071
  64. Sofia A. Costa Lima; André Gaspar; Salette Reis; Luísa Durães. "Multifunctional nanospheres for co-delivery of methotrexate and mild hyperthermia to colon cancer cells". Materials Science and Engineering: C 75 (2017): 1420-1426. https://doi.org/10.1016/j.msec.2017.03.049.
    10.1016/j.msec.2017.03.049
  65. Ana Rute Neves; Joana Fontes Queiroz; Sofia A. Costa Lima; Salette Reis. "Apo E-Functionalization of Solid Lipid Nanoparticles Enhances Brain Drug Delivery: Uptake Mechanism and Transport Pathways". Bioconjugate Chemistry 28 4 (2017): 995-1004. https://doi.org/10.1021/acs.bioconjchem.6b00705.
    10.1021/acs.bioconjchem.6b00705
  66. Gaspar, A.S.; Wagner, F.E.; Amaral, V.S.; Costa Lima, S.A.; Khomchenko, V.A.; Santos, J.G.; Costa, B.F.O.; Durães, L.. "Development of a biocompatible magnetic nanofluid by incorporating SPIONs in Amazonian oils". Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy 172 (2017): 135-146. http://www.scopus.com/inward/record.url?eid=2-s2.0-84963819416&partnerID=MN8TOARS.
    10.1016/j.saa.2016.04.022
  67. Chaves, L.L.; Costa Lima, S.A.; Vieira, A.C.; Barreiros, L.; Segundo, M.A.; Ferreira, D.; Sarmento, B.; Reis, S.. "PH-sensitive nanoparticles for improved oral delivery of dapsone: Risk assessment, design, optimization and characterization". Nanomedicine 12 16 (2017): 1975-1990. http://www.scopus.com/inward/record.url?eid=2-s2.0-85026748544&partnerID=MN8TOARS.
    10.2217/nnm-2017-0105
  68. Ferreira, M.; Barreiros, L.; Segundo, M.A.; Torres, T.; Selores, M.; Reis, S.. "Topical co-delivery of methotrexate and etanercept using lipid nanoparticles: A targeted approach for psoriasis management". Colloids and Surfaces B: Biointerfaces 159 (2017): 23-29. http://www.scopus.com/inward/record.url?eid=2-s2.0-85026661669&partnerID=MN8TOARS.
    10.1016/j.colsurfb.2017.07.080
  69. Cavalcanti, S.M.T.; Nunes, C.; Lima, S.A.C.; Soares-Sobrinho, J.L.; Reis, S.. "Multiple Lipid Nanoparticles (MLN), a New Generation of Lipid Nanoparticles for Drug Delivery Systems: Lamivudine-MLN Experimental Design". Pharmaceutical Research 34 6 (2017): 1204-1216. http://www.scopus.com/inward/record.url?eid=2-s2.0-85015624217&partnerID=MN8TOARS.
    10.1007/s11095-017-2136-0
  70. Silva, E.; Barreiros, L.; Segundo, M.A.; Costa Lima, S.A. (corresponding author); Reis, S.. "Cellular interactions of a lipid-based nanocarrier model with human keratinocytes: Unravelling transport mechanisms". Acta Biomaterialia 53 (2017): 439-449. http://www.scopus.com/inward/record.url?eid=2-s2.0-85010934600&partnerID=MN8TOARS.
    10.1016/j.actbio.2017.01.057
  71. Mara Ferreira; Elisabete Silva; Luísa Barreiros; Marcela A. Segundo; Sofia A. Costa Lima; Salette Reis. "Methotrexate loaded lipid nanoparticles for topical management of skin-related diseases: Design, characterization and skin permeation potential". International Journal of Pharmaceutics 512 1 (2016): 14-21. https://doi.org/10.1016/j.ijpharm.2016.08.008.
    10.1016/j.ijpharm.2016.08.008
  72. Segundo, Marcela A.; Abreu, Vera L. R. G.; Osorio, Marcelo V.; Nogueira, Sonia; Lin, Paul Kong Thoo; Cordeiro-da-Silva, Anabela; Lima, Sofia A. C.. "Development and validation of HPLC method with fluorometric detection for quantification of bisnaphthalimidopropyldiaminooctane in animal tissues following administration in polymeric nanoparticles". Journal of Pharmaceutical and Biomedical Analysis 120 (2016): 290-296. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000370585700038&KeyUID=WOS:000370585700038.
    10.1016/j.jpba.2015.12.033
  73. Neves, Ana Rute; Queiroz, Joana Fontes; Costa Lima, Sofia A.; Figueiredo, Francisco; Fernandes, Rui; Reis, Salette. "Cellular uptake and transcytosis of lipid-based nanoparticles across the intestinal barrier: Relevance for oral drug delivery". Journal of Colloid and Interface Science 463 (2016): 258-265. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000366961400032&KeyUID=WOS:000366961400032.
    10.1016/j.jcis.2015.10.057
  74. Gouveia, V; Lima, Sofia; Nunes, Cláudia; Reis, Salette. "Non-biologic nanodelivery therapies for rheumatoid arthritis". Journal of Biomedical Nanotechnology (2015):
    10.1166/jbn.2015.2159
  75. Sofia A. Costa Lima (corresponding author); Salette Reis. "Temperature-responsive polymeric nanospheres containing methotrexate and gold nanoparticles: A multi-drug system for theranostic in rheumatoid arthritis". Colloids and Surfaces B: Biointerfaces 133 (2015): 378-387. http://dx.doi.org/10.1016/j.colsurfb.2015.04.048.
    10.1016/j.colsurfb.2015.04.048
  76. Ferreira M; Chaves LL; Lima SA (corresponding author); Reis S. "Optimization of nanostructured lipid carriers loaded with methotrexate: a tool for inflammatory and cancer therapy.". (2015): http://europepmc.org/abstract/med/26169145.
    10.1016/j.ijpharm.2015.07.013
  77. Barros, D.; Lima, S.A.C. (corresponding author); Cordeiro-Da-Silva, A.. "Surface functionalization of polymeric nanospheres modulates macrophage activation: Relevance in Leishmaniasis therapy". Nanomedicine 10 3 (2015): 387-403. http://www.scopus.com/inward/record.url?eid=2-s2.0-84923640156&partnerID=MN8TOARS.
    10.2217/nnm.14.116
  78. Costa Lima, S.A. (corresponding author); Silvestre, Ricardo; Barros, Daniela; Cunha, Joana; Dinis-Oliveira, R.; Cordeiro-da-Silva, Anabela. "Crucial CD8+ T-lymphocyte cytotoxic role in amphotericin B nanospheres efficacy against experimental visceral leishmaniasis". Nanomedicine: Nanotechnology, Biology and Medicine (2014): http://www.sciencedirect.com/science/article/pii/S1549963414000033#.
    10.1016/j.nano.2013.12.013
  79. Pinto, M.F.; Moura, C.C.; Nunes, C.; Segundo, M.A.; Costa Lima, S.A. (corresponding author); Reis, S.. "A new topical formulation for psoriasis: Development of methotrexate-loaded nanostructured lipid carriers". International Journal of Pharmaceutics 477 1-2 (2014): 519-526. http://www.scopus.com/inward/record.url?eid=2-s2.0-84911935101&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2014.10.067
  80. Lima, Sofia. "Surface functionalization of polymeric nanospheres modulates macrophage activation – application in visceral leishmaniasis therapy.". (2014):
    10.2217/NNM.14.116
  81. Roussaki, M.; Hall, B.; Lima, S.C.; Da Silva, A.C.; Wilkinson, S.; Detsi, A.. "Synthesis and anti-parasitic activity of a novel quinolinone-chalcone series". Bioorganic and Medicinal Chemistry Letters 23 23 (2013): 6436-6441. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886946961&partnerID=MN8TOARS.
    10.1016/j.bmcl.2013.09.047
  82. Sofia A. Costa Lima. "Aurones: A Promising Heterocyclic Scaffold for the Development of Potent Antileishmanial Agents". International Journal of Medicinal Chemistry (2012): http://www.hindawi.com/journals/ijmc/2012/196921/.
    10.1155/2012/196921
  83. Mehdi, O.; Françoise, S.; Sofia, C.L.; Urs, G.; Kevin, Z.; Bernard, S.; Igor, S.; et al. "HDAC gene expression in pancreatic tumor cell lines following treatment with the HDAC inhibitors panobinostat (LBH589) and trichostatine (TSA)". Pancreatology 12 2 (2012): 146-155. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862163445&partnerID=MN8TOARS.
    10.1016/j.pan.2012.02.013
  84. Costa Lima, S.A. (corresponding author); Resende, M.; Silvestre, R.; Tavares, J.; Ouaissi, A.; Lin, P.K.T.; Cordeiro-Da-Silva, A.. "Characterization and evaluation of BNIPDaoct-loaded PLGA nanoparticles for visceral leishmaniasis: In vitro and in vivo studies". Nanomedicine 7 12 (2012): 1839-1849. http://www.scopus.com/inward/record.url?eid=2-s2.0-84871263911&partnerID=MN8TOARS.
    10.2217/nnm.12.74
  85. Martins, S.; Costa-Lima, S.; Carneiro, T.; Cordeiro-Da-Silva, A.; Souto, E.B.; Ferreira, D.C.. "Solid lipid nanoparticles as intracellular drug transporters: An investigation of the uptake mechanism and pathway". International Journal of Pharmaceutics 430 1-2 (2012): 216-227. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860780308&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2012.03.032
  86. Costa Lima, S.A. (corresponding author); Rodrigues, V.; Garrido, J.; Borges, F.; Kong Thoo Lin, P.; Cordeiro Da Silva, A.. "In vitro evaluation of bisnaphthalimidopropyl derivatives loaded into pegylated nanoparticles against Leishmania infantum protozoa". International Journal of Antimicrobial Agents 39 5 (2012): 424-430. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859430685&partnerID=MN8TOARS.
    10.1016/j.ijantimicag.2012.01.003
  87. Vilas-Boas, V.; Silva, R.; Gaio, A.R.; Martins, A.M.; Lima, S.C.; Cordeiro-da-Silva, A.; de Lourdes Bastos, M.; Remião, F.. "P-glycoprotein activity in human Caucasian male lymphocytes does not follow its increased expression during aging". Cytometry Part A 79 A 11 (2011): 912-919. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054897494&partnerID=MN8TOARS.
    10.1002/cyto.a.21135
  88. Silva, R.; Carmo, H.; Dinis-Oliveira, R.; Cordeiro-Da-Silva, A.; Lima, S.C.; Carvalho, F.; De Lourdes Bastos, M.; Remião, F.. "In vitro study of P-glycoprotein induction as an antidotal pathway to prevent cytotoxicity in Caco-2 cells". Archives of Toxicology 85 4 (2011): 315-326. http://www.scopus.com/inward/record.url?eid=2-s2.0-79954426149&partnerID=MN8TOARS.
    10.1007/s00204-010-0587-8
  89. Lin, P.K.T.; Hoskins, C.; Ouaissi, M.; Lima, S.C.; Cheng, W.P.; Loureirio, I.; Mas, E.; et al. "In vitro and in vivo anticancer activity of a novel nano-sized formulation based on self-assembling polymers against pancreatic cancer". Pharmaceutical Research 27 12 (2010): 2694-2703. http://www.scopus.com/inward/record.url?eid=2-s2.0-78651326311&partnerID=MN8TOARS.
    10.1007/s11095-010-0268-6
  90. Lima, S.A.C.; Tavares, J.; Gameiro, P.; de Castro, B.; Cordeiro-da-Silva, A.. "Flurazepam inhibits the P-glycoprotein transport function: An insight to revert multidrug-resistance phenotype". European Journal of Pharmacology 581 1-2 (2008): 30-36. http://www.scopus.com/inward/record.url?eid=2-s2.0-38549114108&partnerID=MN8TOARS.
    10.1016/j.ejphar.2007.11.045
  91. Lima, S.A.C.; Cordeiro-Da-Silva, A.; De Castro, B.; Gameiro, P.. "Benzodiazepine-mediated structural changes in the multidrug transporter P-glycoprotein: An intrinsic fluorescence quenching analysis". Journal of Membrane Biology 223 3 (2008): 117-125. http://www.scopus.com/inward/record.url?eid=2-s2.0-53849101372&partnerID=MN8TOARS.
    10.1007/s00232-008-9117-5
  92. Lima, S.A.C.; Cordeiro-da-Silva, A.; de Castro, B.; Gameiro, P.. "Sensitivity of P-glycoprotein tryptophan residues to benzodiazepines and ATP interaction". Biophysical Chemistry 125 1 (2007): 143-150. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750698584&partnerID=MN8TOARS.
    10.1016/j.bpc.2006.07.006
  93. Lima, S.A.C.; Cordeiro-Da-Silva, A.; Gameiro, P.; De Castro, B.. "A method for functional mouse MDR3 P-glycoprotein reconstitution in Escherichia coli lipids". Analytical Biochemistry 338 2 (2005): 350-353. http://www.scopus.com/inward/record.url?eid=2-s2.0-14644420801&partnerID=MN8TOARS.
    10.1016/j.ab.2004.10.022
  94. Lima, S.A.C.; Raposo, M.F.J.; Castro, P.M.L.; Morais, R.M.. "Biodegradation of p-chlorophenol by a microalgae consortium". Water Research 38 1 (2004): 97-102. http://www.scopus.com/inward/record.url?eid=2-s2.0-0345714784&partnerID=MN8TOARS.
    10.1016/j.watres.2003.09.005
  95. Lima, S.A.C.; Castro, P.M.L.; Morais, R.. "Biodegradation of p-nitrophenol by microalgae". Journal of Applied Phycology 15 2-3 (2003): 137-142. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038042051&partnerID=MN8TOARS.
    10.1023/A:1023877420364
Journal issue
  1. Costa Lima, S A; Reis, Salette. "Polymeric Carriers for Biomedical and Nanomedicine Application". Polymers (2020): https://www.mdpi.com/journal/polymers/special_issues/carrier_nanomedicine.
    Published • Invited editor
Thesis / Dissertation
  1. Martins, Patrícia Varela Oliveira,1988-. "Drug screening of Bisnaphthalimidopropyl derivatives on Trypanosoma brucei". Master, 2012. http://hdl.handle.net/10451/8390.
  2. Costa Lima, S A. "Evaluation of the structure and function of P-glycoprotein, membrane transporter, in the presence of benzodiazepines and tuberculostatics". PhD, Universidade do Porto Faculdade de Ciências, 2007.
  3. Costa Lima, S A. "Production of oral vaccines in Solanum tuberosum L.". Master, De Montfort University, 1999.

Intellectual property

Provisional application for patent
  1. 2021. "Colorimetric nanosensor for SARS-CoV-2 (NPAT404/2020)".
    Disclosed
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/11/15 Lipid Nanoparticles in Action: Powering Hyaluronic Acid Production in Skin Cells XXVI Encontro Galego-Portugués de Química
(Vigo, Spain)
2024/11/15 Breaking bAD: using chemistry, biophysics and biotechnology to unburden Atopic Dermatitis XXVIII Encontro Galego-Portugués de Química
(Vigo, Spain)
2024/09/09 Unveiling the effects of shrimp hydrolysate as a dietary supplement in healthy adult Beagle dogs XIII Jornadas de Alimentação Animal
2024/02/15 A sea of nano-possibilities: marine hybrid hydrogels combined with nanoparticles to treat Atopic Dermatitis NALS - Nanomaterials Applied to Life Sciences 2024
(Granada, Spain)
2023/11/23 Comparative analysis of kappa- and iota-carrageenan hydrogels for effective skin delivery International Conference on Nanotechnology Research and Innovation
Universidade de Aveiro (Aveiro, Portugal)
2023/11/23 One nano-step closer to improve Atopic Dermatitis symptoms XXVII Encontro Luso-Galego de Química
(Porto, Portugal)
2023/11/23 Olive pomace extract as a multi-functional bioresource for macrophage polarity modulation XXVII Encontro Luso-Galego de Química
(Porto, Portugal)
2023/10/13 Effects of shrimp hydrolysate powder in the general health of adult dogs and palatability of diets Annual Workshop of Doctoral Programme in Animal Science
(Vila do Conde, Portugal)
2023/05/29 Application of nanotechnoloy to overcome the skin barrier International Conference Recent Achievements in Nanotechnology
University of Bialystok (Bialystok, Poland)
2023/05/10 Olive pomace valorisation by obtention of a bioactive compounds enriched extract 16h IJUP
University of Porto (Porto, Portugal)
2023/02/08 Breaking the Skin Barrier through Advanced Nanoplatforms LAQV-REQUIMTE Webinar 2023
LAQV-REQUIMTE (Portugal)
2022/11/16 Searching for the chemistry that works: formulating hydrogels and nanogels towards atopic dermatitis therapy XXIII Encontro Galego-Português de Quimica
Facultad de Química Universidad de Santiago de Compostela (Santiago de Compostela, Spain)
2022/11/16 Characterization of kappa- and iota- carrageenans-based hydrogels as potential vehicles in skin delivery XXII Encontro Luso-Galego de Química
Facultad de Química Universidad de Santiago de Compostela (Santiago de Compostela, Spain)
2022/09/04 Marine protein sources in dog feeding: nutritive value and palatability of squid meal and shrimp hydrolysate 73rd EAAP Annual Meeting
European Federation of Animal Science (Porto, Portugal)
2022/06/30 Evaluation of transdermal permeation of phthalate angico gum nanoparticles containing nevirapine in microneedles InnovDelivery 2022
Universidade Lusófona (Lisboa, Portugal)
2022/06/30 Betamethasone-loaded hybrid hydrogels to manage atopic dermatitis InnovDelivery 2022
Universidade Lusófona (Lisboa, Portugal)
2022/06/30 Exploiting smart delivery systems to slow down skin ageing InnovDelivery 2022
Universidade Lusófona (Lisboa, Portugal)
2022/06/30 Quercetin-loaded lipid nanoparticles with improved antioxidant capacity potential for skin applications InnovDelivery 2022
Universidade Lusófona (Lisboa, Portugal)
2022/06/03 Synchrotron-based Infrared Microspectroscopy of nanoplatforms and skin: unveiling molecular interactions Biophysics Festival 2022
Universidade de Aveiro (Aveiro, Portugal)
2022/05/17 Profiling the effect of skin-targeted nanoplatforms through synchroton FTIR microspectroscopy 6º Encontro de Biotecnologia Microbiana e Farmacêutica
Universidade do Porto, Faculdade de Farmácia (Porto, Portugal)
2021/11/08 Human stratum corneum lipid-based mimetic model: a tool to study drugs' permeability 3rd E-Meeting on Polymer Science & Biomaterials (Polybiomat-2021)
2021/10/20 Nanoparticles to prevent SARS-CoV-2 transmission Modtissimo - Scientific Developments Regarding Protection Against Pathogens such as Sars-Cov-2 (online conference)
CITEVE (Portugal)
2021/09/17 Breaking the barrier: N-acetyl-cysteine-loaded nanoparticles as a strategy to disrupt bacterial biofilms ESB 2021 – 31ST Conference of the European Society for Biomaterials.
European Society for Biomaterials. (Spain)
2021/06/17 Understanding Cell-Nanoparticle Interaction: a new gateway to disease therapeutics XVII Congress of Iberian Society of Flow Citometry
Instituto Português de Oncologia do Porto
2021/05/06 Optimization of topical delivery for niacinamide using hydrogels and transethosomes 14th IJUP
University of Porto
2021/02/22 Nanotechnological approaches to STOP SARS-CoV-2 transmission JorTec DCM – Jornadas Tecnológicas do Departamento de Ciência dos Materiais
Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa, online conference
2020/11/18 Overcoming the skin barrier: in vitro models and nanostrategies to enhance drug absorption Webinar @ Lunch
University of Florence
2020 Quercetin-loaded Hydrogels for Skin Ageing and Inflammation NanoPT
2019/11/22 Fucoidan/chitosan nanoparticles: delivery system for synthetized xanthone towards a in cancer therapy Simpósio de Investigação da Faculdade de Farmácia da Universidade do Porto, Porto
Faculdade de Farmácia da Universidade do Porto, Porto (por, Portugal)
2019/06/12 Unravelling drug’s permeation and transport mechanisms of lipid nanocarriers using in vitro skin models EUFEPS Open Forum
(Bonn, Germany)
2018/11/22 Topical delivery of cyclosporine A using lipid nanoparticles XXIV Encontro Luso-Galego
Faculty of Science, University of Porto (Porto, Portugal)
2018/11/22 Fighting bacterial resistance: a novel nanosystem for N-acetyl-cysteine (NAC) delivery XXIV Encontro Luso-Galego
University of Porto (po, Portugal)
2018/11/21 Targeting and killing the ever-challenge ulcer bug XXIV Encontro Luso-Galego
Faculty of Science, University of Porto (Porto, Portugal)
2018/02/12 Topical delivery of methotrexate using Fucoidan/Chitosan nanoparticles 11st IJUP
University of Porto (Porto, Portugal)
2018/02/08 Development and characterization of pH sensitive fucoidan-chitosan nanoparticles for oral delivery of methotrexate 11st IJUP
University of Porto (po, Portugal)
2018/02/08 Vitamin A encapsulation in lipid nanoparticles for food applications: development, characterization and stability 11st IJUP
University of Porto (Porto, Portugal)
2018/02/08 Cyclosporine A-loaded solid lipid nanoparticles for topical application 11st IJUP
Universidade do Porto (Porto, Portugal)
2018/02/08 Preparation and characterization of nanostructured lipid carriers for methotrexate delivery into breast-cancer cells – a hyperthermia approach. 11st IJUP
Universidade do Porto (Porto, Portugal)
2017/12/07 Chromatographicc analysis of biological samples using monolithic columns. 10th Encontro Nacional de Cromatografia
(Bragança, Portugal)
2017/11/16 Nanoplatforms as diagnostic and therapeutic tools. Conference + Bioquímica
Faculty of Science and Technology, Lisbon (Lisboa, Portugal)
2017/11/16 Application of lipid nanoparticles containing vitamin A in food: development and physico-chemical stability studies. XXIII Encontro Galego-Português de Quimica
(Ferrol, Spain)
2017/02/09 Chitosan/Fucoidan pH sensitive nanoparticles for delivery of methotrexate 10th IJUP-Encontro Investigação Jovem da Universidade do Porto 2017
University of Porto (po, Portugal)
2017/02/08 Development of Cyclosporine A-loaded lipid nanoparticles (LN) formulations for topical application 10th IJUP-Encontro Investigação Jovem da Universidade do Porto 2017
University of Porto (Porto, Portugal)
2017/02/03 Cyclosporine A-loaded solid lipid nanoparticles versus nanostructured lipid carriers for dermal applications NanoPT 2017
(Porto, Portugal)
2017/02/02 Amoxicillin-loaded lipid nanoparticles: a novel approach to treat Helicobacter pylori infections NanoPT 2017
(por, Portugal)
2016/11/10 Development and optimization of amoxicillin-loaded lipid nanoparticles as a therapeutic approach for Helicobacter pylori infections XXII Encontro Luso-Galego de Química
(Bragança, Portugal)
2016/11/09 Development and validation of HPLC method for quantification of dapsone and clofazimine loaded nanoparticles upon bioavailability assessment XXII Encontro Luso-Galego de Química
(Bragança, Portugal)
2016/03/06 Challenges and Advances in Oral Drug Delivery using Lipid-based Nanoparticles. Pharmaceutica 2016
(Madrid, Spain)
2016/02/18 Nanostructured Lipid Carriers: a new approach for Psoriasis topical therapy NanoPT 2016
(Braga, Portugal)
2015/11/20 Identification of keratinocytes’ interaction with nanostructured lipid carriers II Congresso Internacional de Saúde Gaia-Porto
Escola Superior de Saúde (Vila Nova de Gaia, Portugal)
2015/05/14 Application of box-behnken design to optimize methotrexate loaded nanostructured lipid nanoparticles 8th IJUP- Encontro Investigação Jovem da Universidade do Porto 2015
Universidade do Porto (Porto, Portugal)
2015/04/18 Why and how to assess the toxicity at the cell scale of new nanoprobes? COST TD1402 - RADIOMAG Annual Meeting
COST TD1402 (Lisboa, Portugal)
2015/02/09 pH sensitive liposomes loading prednisolone for the treatment of rheumatoid arthritis. NanoPT 2015
(Porto, Portugal)
2015/02/09 New insights in the development of solid lipid nanoparticles for active brain-targeted drug delivery NanoPT 2015
(Porto, Portugal)
2015/02/09 Temperature-responsive polymeric nanospheres containing methotrexate and gold nanoparticles: a multidrug system for theranostics in rheumatoid arthritis NanoPT 2015
(Porto, Portugal)
2014/12/02 Targeted pH sensitive liposomes for the treatment of rheumatoid arthritis Luso-Galego
(Porto, Portugal)
2014/12/02 Solid lipid nanoparticles as a vehicle for brain-targetted drug delivery Luso-Galego
(Porto, Portugal)
2014/11/06 Methotrexate-loaded lipid-based nanoparticles for topical therapy of psoriasis: Optimization and characterization Jornadas Bioengenharia FEUP
(Porto, Portugal)
2014/10/12 A theranostic approach using methotrexate-loaded polymeric nanospheres containing Gold nanoparticles for Rheumatoid Arthritis. Annual Meeting COST ActionTD1004
COST TD1004 (Istambul, Turkey)
2014/06/21 Development of Innovative Therapeutic Approaches for Rare Diseases Training Seminar
(Riga, Latvia)
2013/12/12 Validated chromatographic method for fluorimetric determination of an anti-Leishmania compound in mice tissues 8º Encontro Nacional de Cromatografia
2013/06/06 Crucial CD8+ T-lymphocyte cytotoxic role in amphotericin B nanospheres efficacy against experimental visceral leishmaniasis Infection and Immunity Unit Meeting
IBMC (Porto, Portugal)
2012/11/20 Mannosylated nanoparticles for targeted delivery of amphotericin B towards visceral leishmaniasis XVI Congresso Português de Parasitologia
(Lisboa, Portugal)
2012/11/20 Drug screening of bisnaphthalimidopropyl derivatives on Trypanosoma brucei XVI Congresso Português de Parasitologia
(Lisboa, Portugal)
2012/09/14 The role of bisnaphthalimidopropyl derivatives to control trypanosomatid neglected infections COST Annual Meeting
COST CM801 (Chania, Greece)
2012/05/16 Avaliação da atividade in vitro e in vivo do BNIPDaoct encapsulado em nanopartículas poliméricas no parasita Leishmania infantum Jornadas de Parasitologia II, Escola Superior de Tecnologia da Saúde do Porto
Escola Superior de Tecnologia da Saúde do Porto (Vila Nova de Gaia, Portugal)
2011/11/14 In vitro evaluation of BNIPDaoct encapsulated on polymeric nanoparticles on Leishmania infantum parasite VI Congresso Científico da Associação de Estudantes da Faculdade de Farmácia da Universidade do Porto
Associação de Estudantes da Faculdade de Farmácia da Universidade do Porto (Porto, Portugal)
2011/10/06 Improvement of in vitro and in vivo antileishmanial activities of Bisnaphthalimidopropyldiaaminooctane by encapsulation in poly(D,L-lactide-co-glycolide nanoparticles III Congress of the Portuguese Society of Pharmaceutical Sciences and IX Spanish-Portuguese Conference on Controlled Drug Delivery
(Porto, Portugal)
2011/03/13 The use of poly(lactic-co-glycolic acid) nanoparticles to encapsulate amphotericin B towards visceral leishmaniasis 12th Drug Design and Development
(Heidelberg, Germany)
2011/01/10 Nanotechnology as a tool towards trypanosomatids and pancreatic cancer chemotherapies Invited Seminar
University of Vigo (Vigo, Spain)
2010/09/20 Development of new therapeutics based on the identification of molecular drug targets and on drug screening against the mammalian stage of the parasite. 3rd Scientific Division Day of the Infection and Immunity Unit
IBMC (Porto, Portugal)
2010/05/16 Nanotechnology as a tool towards trypanosomiasis and leishmaniasis chemotherapies 2nd Joint Expert Meeting among Working Groups 1/2/3/4 and MC Meeting of the COST Action CM0801
COST Action CM0801 (Siena, Italy)
2009/05/10 Effect of bisnaphthalimidopropyl polyamine derivatives against experimental Leishmania infantum infection by cytosolic SIR2 related protein 1 Joint Expert Meeting between Working Groups 1 and 3 of the COST Action CM0801
COST Action CM0801 (Sófia, Bulgaria)
2001/07/19 Degradation of p-chlorophenol and p-nitrophenol by a microalgae community 10th European Congress in Biotechnology
(Madrid, Spain)
1998/07/15 Characterisation of bacterial isolates from Serra da Estrela Cheese via analysis of their electrophorectic protein profiles BIOTEC'98
(Guimarães, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/02/01 - Current Alternative protein sources in pet food - a nanotechnological approach
Supervisor
 Licenciatura em Bioquímica (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
2022/10/01 - Current Design of a targeted drug delivery system to reshape the perifollicular microenvironment in androgenetic alopecia
Co-supervisor
 Doctoral Programme on Cellular and Molecular Biotechnology Applied to Health Sciences (BiotechHealth) (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/09/01 - Current Synthesis of polyphenol-conjugated lipid nanoparticles for macrophage modulation
Co-supervisor
 Mestrado em Química Farmacêutica (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2021/10/01 - Current Design of a hyaluronic acid delivery system to slow down skin ageing
Co-supervisor
 Doctoral Program in Pharmaceutical Sciences (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal

REQUIMTE LAQV Porto, Portugal
2021/05/01 - Current Tackling microbial resistance: transdermal delivery of antibiotic drugs as Ionic Liquids and Organic Salts using nanostructured biomaterials
Co-supervisor
 Programa Doutoral em Química Sustentável (PhD)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2020/10 - Current Natural hydrogels as an Intracanal Therapeutic Tool - combination of antimicrobial and photodynamic therapies to prevent reinfections
Supervisor of Sónia Ferreira
 Programa Doutoral Ciências Biológicas Aplicadas à Saúde (PhD)
Instituto Universitário de Ciências da Saúde, Portugal
2020/02/10 - Current Controlled modulation of macrophages by sugar-functionalized nanoparticles.
Co-supervisor of Mariana Romanholo
Mestrado em Ciências Farmacêuticas (Degree)
Universidade do Porto Faculdade de Farmácia, Portugal
2020/10 - 2024/10/25 Development and evaluation of berberine nanoparticles as an antimicrobial tool in endodontic irrigation
Supervisor of Célia Marques
 Programa Doutoral Ciências Biológicas Aplicadas à Saúde (PhD)
Instituto Universitário de Ciências da Saúde, Portugal
2020/01/01 - 2024/10/11 Marine-based nanotechnological approaches for dermatitis in developing countries
Co-supervisor of Ana Isabel Barbosa
Programa Doutoral BiotechHealth (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019/10/01 - 2023/09/30 Novel functional ingredients in pet food - a multifactorial study of alternative diets for dogs
Co-supervisor
 Programa Doutoral SANFEED (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017/01/02 - 2022/12/19 Improving health and growth in gilthead seabream (Sparus aurata) through fortified nutrition: discovering new nutraceuticals from marine bio-refineries
Co-supervisor of Bruno Reis
Programa Doutoral SANFEED (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021/03/01 - 2021/10/07 Alginate-derived microneedle devices for transdermal delivery of rivastigmine - application in skin mimetic model
Co-supervisor
 Mestrado Integrado em Bioegenharia (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/03/01 - 2021/09/22 Synthesis of sugar-coated marine polymeric nanosystems for topical delivery of bioactive agents
Supervisor of Filipa Serrasqueiro
 Mestrado em Química Farmacêutica (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2020/10/02 - 2021/03/29 Optimization of topical delivery of niacinamide using hydrogels and transethosomes for anti-ageing
Supervisor
 Mestrado Integrado em Bioengenharia (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019/02/02 - 2019/09/02 Development and Characterization of Lipid Nanoparticles for Topical Drug Administration
Co-supervisor of Simone Stefani
Chemistry and Pharmaceutical Technology Master (Master)
Università degli Studi di Modena e Reggio Emilia Biblioteca Universitaria Umanistica, Italy
2019/02/14 - 2019/07/17 Application of gold nanoparticles in fingermarks detection – optimization of detection process
Supervisor of Bruna Faria
Licenciatura em Ciências Laboratoriais Forenses (Degree)
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2018/03/10 - 2018/07/26 Development of gold nanoparticles in fingermarks detection
Supervisor of Application of gold nanoparticles in fingermarks detection
 Licenciatura em Ciências Laboratoriais Forenses (Degree)
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2017/09/02 - 2018/07/20 Lipid-based nanocarriers for food applications: strategies to maximize bioactive compounds’ bioavailability and their safety evaluation
Co-supervisor of Daniela Resende
Bioeengenharia (Master)
Universidade do Porto Faculdade de Engenharia, Portugal
2017/09/06 - 2018/02/26 Cyclosporine A-loaded solid lipid nanoparticles for topical application
Supervisor of Maria Inês Silva
Mestrado Integrado em Ciências Farmacêuticas (Degree)
Universidade do Porto Faculdade de Farmácia, Portugal
2017/12/01 - 2017/12/31 Hidrogéis híbridos - desenvolvimento de uma terapia tópica para a psoríase
Co-supervisor of Mafalda Patrício
Programa Doutoral em Ciências Farmacêuticas (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal
2016/10/02 - 2017/11/06 In vitro skin models as a tool in the optimization of drug formulation
Supervisor of Zinaida Shakel
 Bioquímica (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2016/09/10 - 2017/07/20 Delivery of methotrexate using fucoidan/chitosan pH sensitive nanoparticles
Co-supervisor of Ana Isabel Ferreira Barbosa
 Química Farmacêutica (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2014/10/10 - 2015/07/16 NLC keratinocytes’ uptake mechanism
Supervisor of Elisabete Silva
 Anatomo-pathology Technologist (Degree)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2014/09/04 - 2015/07/14 Nanostructured Lipid Carriers: a new approach for Psoriasis dermal therapy
Supervisor of Mara Ferreira
 Biomedical Engineering Master (Master)
2014 - 2014 Application of lipid nanoparticles for the delivery of methotrexate for dermal treatment of psoriasis
Supervisor of Maria Filipa Sanches Pinto
 Bioengenharia (Master)
Universidade do Porto Faculdade de Engenharia, Portugal
2011/09/14 - 2013/11/26 Study of the Erlotinib (Tarceva) anticancer activity on liposomes
Co-supervisor of Rita Vidal
 Mestrado em Tecnologia Farmacêutica (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2013/02/08 - 2013/07/10 Drug screening in Leishmania promastigotes
Co-supervisor of Melissa Raboni
 Mestrado integrado em Ciências Farmacêuticas (Degree)
Universidade do Porto Faculdade de Farmácia, Portugal
2011/10/02 - 2012/11/29 Drug screening of the bisnaphthilimidopropil derivatives on Trypanosoma brucei
Supervisor of Patrícia Varela Martins
 Cellular Biology and Biotechnology (Master)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2011/09/15 - 2012/10/26 Mannosylated nanoparticles for targeted delivery of amphotericin B towards visceral leishmaniasis
Supervisor of Daniela Barros
 Biochemistry (Master)
2012/02/07 - 2012/09/18 Drug target identification in Leishmania
Supervisor of Sónia Nogueira
Mestrado Integrado em Ciências Farmacêuticas (Degree)
Universidade do Porto Faculdade de Farmácia, Portugal
2010/10/10 - 2011/06/08 Development and characterisation of paromomycin nanoparticles towards cutaneous leishmaniasis
Supervisor of Raquel Carneiro
Licenciatura em Biologia (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
2009/09/12 - 2010/06/04 Development and characterisation of bisnaphthalimidopropyl polyamine derivatives nanoparticles towards Leishmania infantum protozoa
Co-supervisor of Susana Sampaio
 Biology (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
2008/09/15 - 2010/01/07 Nanoparticles as drug delivery systems towards leishmaniasis: the effect of PEGylation
Co-supervisor of Vasco Rodrigues
Biochemistry (Master)
2007/10/01 - 2008/07/25 Characterization and optimization of poly(D,L-lactide-co-glycolide nanoparticles against Leishmania
Co-supervisor of João Pedro Silva
 Biochemistry (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
2007/10/02 - 2008/06/25 Development and characterization of poly-lactic acid nanoparticles towards Leishmania protozoa
Co-supervisor of João Barbosa
 Biochemistry (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
2002/09/14 - 2003/06/22 Drug partition determination in DMPC and DMPG liposomes
Co-supervisor of Susana Silva
 Chemistry (Other)
Universidade do Porto Faculdade de Ciências, Portugal
2001/09/20 - 2002/06/20 Aromatic compounds degradation by Chlorella vulgaris
Co-supervisor of Maria João Saraiva
 Microbiology (Degree)
Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
2001/09/20 - 2002/06/20 Aromatic compounds degradation by Chlorella vulgaris
Co-supervisor of Mónica Silva
 Microbiology (Degree)
Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2024/11/04 - Current "One Health - Uma Saúde um contributo da universidade" book presentation at the University of Porto Rectory for the One Health International Day celebration. (2024/11/04)
Other (Member of the Organising Committee)
 Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/09/05 - Current One Health Talks (2023/10/23)
Round table (Member of the Organising Committee)
 Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019 - Current Universidade Júnior, program of Porto University in the project: À descoberta da nanotecnologia: aplicações na saúde e na alimentação (2019/07) Universidade do Porto, Portugal
2017 - Current Universidade Júnior, program of Porto University in the project: À descoberta da nanotecnologia: aplicações na saúde e na alimentação (2017)
2011 - Current Workshop on New antiparasitic and anticancer drugs, funded by the ERA-NET New Indigo network (2011)
Workshop (Member of the Organising Committee)
 Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2023/04/02 - 2023/11/04 Organização d "Expo One Health" (2023/11/02 - 2023/11/04)
Exhibition (Member of the Organising Committee)
 Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/09/13 - 2023/09/15 Annual Meeting NetSkinModels COST Action - Porto (2023/09/13 - 2023/09/15)
Meeting
 NetSkinModels COST Action, Austria
2022/01/17 - 2022/01/21 Winter School on Membrane Biophysics: Impact of Lipids on Health, Disease and Therapy (3rd edition) (2022/01/17)
Workshop (Co-organisor)
 Universidade do Porto Faculdade de Farmácia, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019/06/12 - 2019/06/14 Advanced course on "Protein-ligand interactions: From theory to practice" (2019)
Other (Member of the Organising Committee)
 Universidade do Porto Faculdade de Farmácia, Portugal
2019/05/21 - 2019/05/24 Advanced course in "In vitro models of biological barriers for Health Sciences Applications" (2019)
Other (Member of the Organising Committee)
 Universidade do Porto Faculdade de Farmácia, Portugal
2018/07/02 - 2018/07/13 Universidade Júnior, program of Porto University in the project: À descoberta da nanotecnologia: aplicações na saúde e na alimentação (2018/07/02 - 2018/07/13)
Workshop (President of the Organising Committee)
 Universidade do Porto Faculdade de Farmácia, Portugal
2018/06/25 - 2018/06/29 Summer School on Membrane Biophysics: Impact of Lipids on Health, Disease and Therapy (2nd edition) (2018/06/25)
Workshop (Member of the Organising Committee)
 Universidade do Porto Faculdade de Farmácia, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017/07/24 - 2017/07/28 Summer school on Membrane Biophysics: Impact of Lipids on Health, Disease and Therapy (2017/07/24)
Workshop (Member of the Organising Committee)
 Universidade do Porto Faculdade de Farmácia, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
1998 - 1998 Jornadas de Microbiologia (1998)
Symposium (Member of the Organising Committee)
 Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2024/11/16 - Current Workshop Doctoral Program in Animal Science 2024
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/10/15 - Current Workshop Doctoral Programme in Animal Science 2023
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/06/21 - Current Annual Workshop of Doctoral Program BiotechHealth 2023
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/09/15 - Current Workshop Doctoral Programme in Animal Science 2022
Workshop
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2024/11/03 - 2024/11/08 Webinar entitled "Phytotherapy in cosmetics and therapeutics" within 2nd edition of the Advanced Doctoral Course "Topical and Transdermal Delivery".
Workshop
Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/04/05 - 2023/04/07 Webinar Organ and Tissue Engineering
Workshop
Université Paris-Saclay, France
2023/02/14 - 2023/02/18 Annual Meeting NetSkinModels COST Action - Bratislava, Slovakia
Other

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024/07/29 Oncostatin M: a multifaceted cytokine able to modulate inflammation
(Thesis) Main arguer
 Anabela Ferreira Gonçalves (PhD)
Universidade do Minho, Portugal
2024/07/15 Development of an Immunomodulatory and ProAngiogenic Hydrogel to Advance the Healing of Chronic Wounds
(Thesis) Main arguer
 Rita Gomes (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2024/06/28 Cryobiophysics: Structure-Function-Property-Design Interplay of Polysaccharides in Crystal Binding
(Thesis) Main arguer
 Bruno Miguel Soares Guerreiro (PhD)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2023/10/11 Exploring Thermoresponsive Chitosan – Pluronic® F-127 hydrogels for antimicrobial peptide release
(Thesis) Main arguer
 Maria Carolina Antunes Matias (Master)
Universidade do Porto Faculdade de Engenharia, Portugal
2023/10/06 Production of Lipid Nanoparticles for Topical Administration of Flavonoids
Thesis Member
 Raquel Pinho Costa (PhD)
Universidade do Porto Faculdade de Ciências, Portugal
2023/05/11 SYNTHESIS AND CHARACTERIZATION OF IONIC LIQUIDS AND EVALUATION OF THEIR APPLICABILITY IN NEW PHARMACEUTICAL FORMULATIONS
President of the jury
 Rita Alexandra Mourato dos Reis Caparica (PhD)
Universidad de Alcalá, Spain
2022/11/20 Development of an in vitro model of mucinous tumours
(Thesis) Main arguer
 Ana Luísa Benavente (Master)
Universidade Nova de Lisboa Departamento de Química, Portugal
2022/10/20 Unveiling membrane dependent mechanism of action of molecules with anticancer activity
(Thesis) Main arguer
 Daniela Oliveira (Master)
Universidade do Porto Faculdade de Engenharia, Portugal
2022/10/03 Establishment of an Experimental Protocol for Assessing the Transport of Nanoparticles in Breast Cancer Spheroids
(Thesis) Main arguer
 Marta Isabel Miguel de Miranda e Amaral de Avelar (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/09/29 Development of porous microneedles: a novel approach to collect biomarkers for organ-on-a-chip monitoring
(Thesis) Main arguer
 Renata Maia (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/06/03 APLICAÇÃO DE BIOPOLIMERO MODIFICADO DE GOMA DO ANGICO EM SISTEMAS DE LIBERAÇÃO: UMA ABORDAGEM UTILIZANDO MICROAGULHAS
(Thesis) Main arguer
 Thaisa Cardoso de Oliveira (PhD)
Universidade Federal de Pernambuco, Brazil
2022/02/24 Pharmaceutical Ionic Liquids as an Effective Treatment against Mycobacterium Tuberculosis
(Thesis) Main arguer
 Hugo Araújo (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022/01/27 Optimization of nanoparticles for the release of icilin in rheumatic diseases
(Thesis) Main arguer
 Diana Sousa (Master)
Universidade do Minho Centro de Engenharia Biológica, Portugal
2021/02 Fabrication of a Yeast Microcapsule Platform for Bone Tissue Regeneration
(Thesis) Main arguer
 Patrícia Gaspar de Oliveira (Master)
Universidade de Aveiro Departamento de Engenharia de Materiais e Cerâmica, Portugal
2020/11/12 After the antibiotic era: effect of Nanostructured Lipid Carriers against Helicobacter pylori biofilms
(Thesis) Main arguer
 Ana Sofia Ferreira Leite de Pinho (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/05/11 Lipid nanoparticles biocompatibility and cellular uptake in a 3D human lung model
(Thesis) Main arguer
 Marina Barroso Pereira Pinheiro (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2020 Development of Neurotherapeutic Polyplexes for Oxidative Stress in Ischemic Stroke
(Thesis) Main arguer
 Joana Filipa Ferreira Moreira (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019/07/11 Bioengineering a 3D heterotypic tumor model to study the dynamics of endothelial cells recruitment and growth
(Thesis) Main arguer
 Sara Chaves (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018/10/15 Establishment of tricultures in microfluidic platforms
(Thesis) Main arguer
 Miguel Guilherme Linhas Simões (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018/07/20 Lipid-based nanocarriers for food applications: strategies to maximize bioactive compounds’ bioavailability and their safety evaluation
Supervisor
 Daniela Resende (Master)
Universidade do Porto Faculdade de Engenharia, Portugal
2017/11/06 In vitro skin models as a tool in the optimization of drug formulation
Supervisor
 Zinaida Shakel (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2017/10/12 Polymeric-based nanoparticles targeting the CCR5 co-receptor as an innovative approach for the delivery of antiretroviral compounds
(Thesis) Main arguer
 Catarina Coutinho (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017/10/12 Trimethyl-Chitosan-based Polyplexes for Neurotrophin Mimicking in Brain Ischaemia
(Thesis) Main arguer
 Simão Pedro Barbosa Teixeira (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017/07/21 Delivery of methotrexate using Fucoidan/Chitosan pH sensitive nanoparticles
Supervisor
 Ana Isabel Barbosa (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2017/07/05 Nanostructured lipid carriers as a promising drug delivery system for streptomycin
(Thesis) Arguer
 Sara Pinheiro (Other)
Universidade do Porto Faculdade de Farmácia, Portugal
2017/06/02 New Technologies technologies for the improvement of leprosy multidrug therapy: a quality by design approach
Thesis Member
 Luíse Lopes Chaves (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal
2016/11/13 Antiparasitic potential of natural marine compounds
(Thesis) Main arguer
 Gisela Almeida Castro (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2015/12/11 Protein-based nanodevices for therapeutic applications
(Thesis) Main arguer
 Ana Isabel Loureiro (PhD)
Universidade do Minho Escola de Ciências, Portugal
2015/10/06 Nanoparticle Delivery System for Bone Regeneration
(Thesis) Main arguer
 Joana Nave (Master)
Universidade do Porto Faculdade de Engenharia, Portugal
2015/07/14 Nanostructured Lipid Carriers: a new approach for Psoriasis dermal therapy
Supervisor
 Mara Ferreira (Master)
Universidade do Porto Faculdade de Engenharia, Portugal
2014/12/27 MicroRNA modulation incombination with chemotherapeutic drugs as a novel therapeutic strategy for pancreatic cancer
(Thesis) Main arguer
 Marta Daniela Passadouro Caetano (PhD)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013/07/15 Development of multifunctional nanoparticles for targeted therapy and imaging of rheumatoid arthritis
(Thesis) Main arguer
 Catarina Moura (Master)
Universidade do Porto Faculdade de Engenharia, Portugal
2012/11/29 Drug screening of the bisnaphthilimidopropil derivatives on Trypanosoma brucei
Supervisor
 Patrícia Varela Martins (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2012/10/26 Mannosylated nanoparticles for targeted delivery of amphotericin B towards visceral leishmaniasis
Supervisor
 Daniela Barros (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2010/05/12 Leishmania spp infection model optimization for drug discovery purposes
(Thesis) Main arguer
 Maria Helena Azevedo Teixeira de Andrade (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2010/01/07 Nanoparticles as drug delivery systems towards leishmaniasis: the effect of PEGylation
Supervisor
 Vasco Rodrigues (Master)
Universidade do Porto Faculdade de Ciências, Portugal

Committee member

Activity description
Role 		Institution / Organization
2023/03/10 - Current Membro do Gabinete One Health
Member
 Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/03/06 - Current Membro da Comissão de Acompanhamento de Curso Programa Doutoral em Ciência Animal
Member
 Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020 - Current Editorial Board Member of the journal Marine Drugs, is the leading, peer-reviewed, open access journal on the research, development, and production of biologically and therapeutically active compounds from the sea. IF 5.1 Journal Rank: JCR - Q1 (Chemistry, Medicinal) / CiteScore - Q1 (Pharmacology, Toxicology and Pharmaceutics, miscellaneous) https://www.mdpi.com/journal/marinedrugs
Other
2019/10 - Current Supervisor Member of the International Doctoral Programme in Molecular and Cellular Biotechnology Applied to Health Sciences
Member
 Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Faculdade de Farmácia, Portugal

REQUIMTE LAQV Porto, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2019 - Current Editorial Board Member of the journal Chemistry, peer-reviewed, open access journal on the chemistry, indexed within Scopus, ESCI (Web of Science), CAPlus / SciFinder, and many other databases. https://www.mdpi.com/journal/chemistry
Other
2017 - Current Supervisor Member of the International Doctoral Programme in Sustainable Animal Nutrition and Feeding
Member
 Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Faculdade de Farmácia, Portugal

REQUIMTE LAQV Porto, Portugal

Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
2018/06 - 2022 CA16205: European Network on Understanding Gastrointestinal Absorption-related Processes (UNGAP) as management committee substitute and working group member. https://gbiomed.kuleuven.be/english/research/50000715/50000716/ungap
Member
 European Cooperation in Science and Technology, Belgium
2014 - 2018 TD1402 "Multifunctional Nanoparticles for Magnetic Hyperthermia and Indirect Radiation Therapy (RADIOMAG)" as management committee, group leader and working group member http://www.cost-radiomag.eu/
Member
 European Cooperation in Science and Technology, Belgium
2014 - 2018 CM1307 "Targeted chemotherapy towards diseases caused by endoparasites" as Management committee substitute and working group member.
Member
 European Cooperation in Science and Technology, Belgium
2015/05/13 - 2015/05/15 Evaluation of research works presented as poster communication in the field of Chemistry at IJUP
Member
 Universidade do Porto, Portugal
2012 - 2014 TD1004 "Theranostics Imaging and Therapy: An Action to Develop Novel Nanosized Systems for Imaging-Guided Drug Delivery" as working group member
Member
 European Cooperation in Science and Technology, Belgium
2013/02/13 - 2013/02/15 Evaluation of research works presented as poster communication in the field of Chemistry at IJUP
Member
 Universidade do Porto, Portugal
2012/02/22 - 2012/02/24 Evaluation of research works presented as poster communication in the field of Chemistry at IJUP
Member
 Universidade do Porto, Portugal
2011/11/21 - 2011/11/25 Evaluator of poster communications presented in the 11th edition of the Trends in Nanotechnology International Conference (TNT2010)
Member
2011/02/17 - 2011/02/19 Evaluation of research works presented as poster communication in the field of Chemistry at IJUP
Member
 Universidade do Porto, Portugal

Conference scientific committee

Conference name Conference host
2022/04/04 - 2022/04/06 7th World Congress on Recent Advances in Nanotechnology Lisbon

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2020/05/12 - Current Nanostrategies for skin delivery: application of in vitro models for drug absorption  Advanced Course “Bionanoparticles: challenges and therapeutic opportunities” (Outros) Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal
2019/06/19 - Current Standard operating procedures (SOPs): theory Advanced course on Protein-ligand interactions: From theory to practice (Outros) Universidade do Porto Faculdade de Farmácia, Portugal
2019/06/19 - Current Experimental protocols and standard operating procedures: practice Advanced course on Protein-ligand interactions: From theory to practice (Outros) Universidade do Porto Faculdade de Farmácia, Portugal
2019/06/18 - Current Hands-on training: Ligand binding immunoassays Advanced course on Protein-ligand interactions: From theory to practice (Outros) Universidade do Porto Faculdade de Farmácia, Portugal
2019/06/17 - Current Ligand binding immunoassays: theory Advanced course on Protein-ligand interactions: From theory to practice (Outros) Universidade do Porto Faculdade de Farmácia, Portugal
2019/05/29 - Current Nanomedicine-based strategies to beat cancer Cancer therapy: from basic research to clinic (Pós-Graduação) Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal
2019/05/24 - Current Hands-on training: Franz diffusion cells Advanced course on In vitro models of biological barriers for Health Sciences Applications (Outros) Universidade do Porto Faculdade de Farmácia, Portugal
2019/05/23 - Current Skin: practical aspects Advanced course on In vitro models of biological barriers for Health Sciences Applications (Outros) Universidade do Porto Faculdade de Farmácia, Portugal
2016/06/02 - Current Multifunctional nanoparticles for cancer magnetic hyperthermia therapy Advanced course on Bionanoparticles: challenges and therapeutic opportunities (Pós-Graduação) Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal
2014/05/28 - Current Multifunctional nanomedicine platforms for Cancer Therapeutics Bionanotechnology for diagnosis and therapy of cancer (Pós-Graduação) Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal
2024/02/05 - 2024/06/30 Química Orgânica e Biológica Licenciatura em Bioengenharia (Licenciatura) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/09/15 - 2024/01/31 Fundamentos da Química e da Biofísica Mestrado Integrado em Medicina Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/02/12 - 2023/06/30 Química Orgânica e Biológica Licenciatura em Bioengenharia Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/09/15 - 2023/01/31 Fundamentos da Química e da Biofísica Mestrado Integrado em Medicina Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/10/06 - 2023/01/20 Fundamentos da Química e da Biofísica Mestrado Integrado em Medicina (Mestrado integrado) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/02/15 - 2022/06/30 Bioquímica Mestrado Integrado em Ciências Farmacêuticas Universidade do Porto Faculdade de Farmácia, Portugal
2021/09/15 - 2022/02/14 Laboratório Forense II Ciências Laboratoriais Forenses (Licenciatura) Instituto Universitário de Ciências da Saúde, Portugal
2020/09/15 - 2021/02/14 Laboratório Forense II Ciências Laboratoriais Forenses Instituto Universitário de Ciências da Saúde, Portugal
2019/09/20 - 2020/02/08 Laboratorio Forense II Ciências Laboratoriais Forenses (Licenciatura) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2018/09/17 - 2019/02/10 Laboratório Forense II Ciências Laboratoriais Forenses (Licenciatura) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2017/09/20 - 2018/02/10 Laboratório Forense II Ciências Laboratoriais Forenses (Licenciatura) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2016/10/02 - 2017/02/12 Laboratório Forense II Ciências Laboratoriais Forenses (Licenciatura) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2015/10/06 - 2016/02/10 Laboratório Forense II Ciências Laboratoriais Forenses (Licenciatura) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2000 - 2001 Microbiologia Geral I Microbiologia (Licenciatura) Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
2000 - 2001 Microbiologia Geral II Microbiologia (Licenciatura) Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
2000 - 2001 Microbiologia Geral II Engenharia Alimentar (Licenciatura) Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
2000 - 2001 Tecnologias e Tratamento de Efluentes II Engenharia do Ambiente (Licenciatura) Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
1999 - 2000 Microbiologia do Ambiente Microbiologia (Licenciatura) Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2024/11/11 - Current Chairnan of the jury of the probatory year exams for the Doctoral Program in Animal Science of the student Adriana Oliveira. Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/11/16 - Current Member of the jury of the probatory year exams for the Doctoral Program in Animal Science of the student Daniela Leal. Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021/07/01 - Current Member of the evaluation panel of doctoral projects presented by 1st year students of the Doctoral Program BiotechHealth. Universidade do Porto Faculdade de Farmácia, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/03 - Current Grant Reviewer
Evaluator
 National Science Centre Poland , Poland
2019/07/01 - Current Member of the evaluation panel of doctoral projects presented by 1st year students of the Doctoral Program BiotechHealth. Universidade do Porto Faculdade de Farmácia, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019 - Current Grant Reviewer
Evaluator
 Graduated Women in Science, United States
2019 - Current Grant Reviewer
Evaluator
 The Israel Science Foundation, Israel
2017 - Current Grant Reviewer
Evaluator
 Université de Bordeaux, France
2014 - Current Evaluator of Trans-Domain COST Action Proposal Call
Evaluator
 European Commission, Belgium European Cooperation in Science and Technology
2010/02/01 - Current Member of the panel on the Pluridisciplinar projects 2010 of Porto University
Evaluator
 Universidade do Porto, Portugal Banco Santander Totta
2024/07/01 - 2024/09/30 Grant reviewer for ANI - National Invocation Agency
2023/05/10 - 2023/07/10 Grant reviewer for HORIZON-HLTH - RIA
Evaluator
 European Commission, Belgium
2017/05/20 - 2018/03/05 Grant Reviewer for European Commission H2020 projects
Evaluator
 European Commission, Belgium European Commission

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2024/11/20 Newsletter of the One Health Commission - announcement of the "One Health - Uma Saúde um contributo da Universidade" the book
2020/07/12 Researchers from Porto take advantage of the qualities of nanoparticles to combat COVID-19 Porto News
2020/07/04 nano2Prevent project: Nanoparticles to kill the virus on the protection individual equipments in the hospital and nursing home Diário de Notícias
2020/07/01 Portuguese researchers fight viruses with nanotechnology Portugal Textil
2020/06/30 Portuguese laboratory wants to combat Covid-19 by incorporating nanoparticles in textiles Sapo24

Interview (tv / radio show)

Program Topic
2024/11/26 - Current U.Porto Press: Livro 2 minutos "ONE HEALTH - UMA SAÚDE" com Adriano A. Bordalo e Sá

Journal scientific committee

Journal title (ISSN) Publisher
2023/02/06 - Current Advanced Therapeutics
2018/10/25 - Current Immunotherapy International
2018/06/02 - Current Biochimica et Biophysica Acta (BBA) - Reviews on Cancer (0304-419X) Elsevier
2018/04/02 - Current ACS Applied Materials & Interfaces
2018/02/04 - Current Journal of Pharmaceutics (2090-7818) Hindawi (International Scholarly Research Network)
2018/02/02 - Current Marine Drugs MDPI
2017/04/10 - Current Polymers (2073-4360) MDPI AG
2017/03/20 - Current Nanomaterials and Nanotechnology (1847-9804) SAGE Publications
2017/03/12 - Current Journal of Advanced Research (2090-1232) Elsevier
2017/03/02 - Current Scientific Reports (2045-2322) Springer Science and Business Media LLC
2017/02/02 - Current Molecules (1420-3049) MDPI AG
2017/01/29 - Current Journal of the Science of Food and Agriculture (1097-0010) Wiley (John Wiley & Sons)
2016/06/03 - Current Current Drug Delivery (1567-2018) Bentham Science
2016/05/02 - Current Chemistry and Physics of Lipids (0009-3084) Elsevier
2016/04/10 - Current Journal of Liposome Research (1532-2394) Informa UK (Taylor & Francis)
2016/04/10 - Current Nanomaterials (2079-4991) MDPI AG
2016/03/10 - Current Journal of Clinical Dermatology & Therapy
2016/03/05 - Current ACS Biomaterials Science & Engineering (2373-9878) American Chemical Society
2015/04/02 - Current Drug Development and Industrial Pharmacy (1520-5762) Informa UK (Taylor & Francis)
2015/02/10 - Current Acta Biomaterialia (1742-7061) Elsevier
2015/02/10 - Current Nanomedicine (1748-6963) Future Medicine
2014/09/04 - Current Biomaterials (0142-9612) Elsevier
2013/04/10 - Current International Journal of Nanomedicine (1178-2013) Dove Medical Press
2011/04/14 - Current Parasitology International (1383-5769) Elsevier
2010/02/10 - Current Colloids and Surfaces B Biointerfaces (0927-7765) Elsevier

Mentoring / Tutoring

Topic Student name
2023/02/01 - Current Nanoencapsulation of bioactive compounds for pets feed Beatriz Silva
2021/09/01 - 2021/09/30 Entrega Transdérmica de fármacos usando biomateriais naturais no controlo da inflamação Ana Catarina dos Santos Dias
2021/04 - 2021/08 Design of advanced resveratrol transdermal delivery systems: Evaluation of drugs permeation in skin mimetic models Alexandra Mujica
2020/02/12 - 2020/07/31 Alginate as base polymer for hydrogels loaded with quercetin Ludovico Esposito
2018/02/02 - 2019/11/30 Thymoquinone-loaded nanostructured lipid carrier: physicochemical characterization and interactions with a breast cancer cell line Ong Yong Sze
2019/07/02 - 2019/09/28 Evaluation of skin permeability of bioactive compounds Sedef Kaplan
2019/02/10 - 2019/07/02 Nanoemulsions of fractions rich in pomegranate polyphenols and their protective effect against fluoride poisoning Kaoutar Chattahy
2018/04/02 - 2018/07/29 Pomegranate seeds applied to nanotechnology Talal Sabraoui
2017/09/05 - 2018/06/30 Development of pH-responsive fucoidan/chitosan nanoparticles Joana Filipa Cardoso
2016/09/02 - 2017/06/28 Controlled release of active ingredients by matrices Abderrazzaq Essaghraoui
2015/09/03 - 2016/02/29 PLGA-Au nanospheres characterisation and validation in rheumatoid arthritis Paola Tibalo
2010/09/15 - 2011/06/15 Development of a resistant strain of L. infantum to BNIPDaoct Sónia Nogueira
2010/02/10 - 2010/10/20 Evaluation of the in vitro biological effects of novel bisnaphthalimidopropyl polyamine derivatives in Leishmania infantumv Tariq Hassam
2009/09/04 - 2010/06/20 Optimisation and characterisation of nanoparticles targeted to macrophages Joana Oliveira
2008/09/10 - 2009/06/13 Evaluation of the in vitro released compounds from polymeric nanoparticles Joana Soares

Other jury / evaluation

Activity description Institution / Organization
2023/11/17 - Current Comissão de Acompanhamento da Tese de Doutoramento em Bioquímica da Universidade Nova de Lisboa,, do estudante Bruno Miguel Soares Guerreiro. Universidade NOVA de Lisboa, Portugal
2023/05/17 - Current Jury member in a public tender for applications for a scientific research position, within the project EVALUATION OF ALTERNATIVE FOOD SOURCES IN DOG FEEDING, under way at Instituto de Ciências Biomédicas de Abel Salazar da Universidade do Porto Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/02/01 - Current Jury member in a public tender for applications for a scientific research scholarship, within the project "NovinDog - new functional ingredients for dog food: a sustainable approach", reference poci-01-0247-feder-047003", under way at Faculdade de Farmácia da Universidade do Porto Universidade do Porto Faculdade de Farmácia, Portugal
2023/01/12 - Current Jury member in a public tender for applications for a scientific research scholarship, within the project R&W Clean - Novas soluções para sensorização de parâmetros ambientais e biológicos para auxílio à desmedicalização do sector agropecuário” (POCI-01-0247-FEDER-070109), under way at Instituto de Ciências Biomédicas de Abel Salazar da Universidade do Porto Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/11/24 - Current Jury member in a public tender for applications for a scientific research scholarship, within the project "NovinDog - new functional ingredients for dog food: a sustainable approach", reference poci-01-0247-feder-047003", under way at Faculdade de Farmácia da Universidade do Porto Universidade do Porto Faculdade de Farmácia, Portugal
2021/07/31 - Current Jury member in a public tender for a research fellowship for a graduated student in the scope of the Project HEALTH-UNORTE: Setting-up Biobanks And Regenerative Medicine Strategies to Boost Research in Neurosciences, Immunology and Infection, Musculoskeletal, Cardiovascular and Oncologic Diseases (refª NORTE-01-0145-FEDER-000039) Universidade do Porto Faculdade de Farmácia, Portugal
2021/01/02 - Current Jury member in a public tender for Master's Research fellowship (Ref. REQUIMTE 2020-29), under the project PTDC/QUI-COL/30834/2017, with the financial support of FCT/MCTES through national funds and when applicable co-financed by the FEDER under the Partnership Agreement COMPETE 2020 Universidade do Porto Faculdade de Farmácia, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
2020/01 - Current Jury member in a public tender for Master's Research fellowship (Ref. REQUIMTE 2020-04), under the project PTDC/QUI-COL/30834/2017, with the financial support of FCT/MCTES through national funds and when applicable co-financed by the FEDER under the Partnership Agreement COMPETE 2020 Universidade do Porto Faculdade de Farmácia, Portugal
2019/11 - Current Jury member in a public tender for Master's Research fellowship (Ref. ICETA 2019-76), under the project PTDC/QUI-COL/30834/2017, with the financial support of FCT/MCTES through national funds and when applicable co-financed by the FEDER under the Partnership Agreement COMPETE 2020 Universidade do Porto Faculdade de Farmácia, Portugal
2019/09 - Current Jury member in a public tender for a Research fellowship (Reference ICETA 2019-76) at the Associated Laboratory for Green Chemistry financed by National Funds through FCT / MCTES and considering the UID's Pluriannual funding UID/QUI/50006/2019 (2020-2023). Universidade do Porto Faculdade de Farmácia, Portugal
2019/03 - Current Jury member in a public tender for Master's Research fellowship (Ref. ICETA 2019-23), under the project PTDC/QUI-COL/30834/2017, with the financial support of FCT/MCTES through national funds and when applicable co-financed by the FEDER under the Partnership Agreement COMPETE 2020 Universidade do Porto Faculdade de Farmácia, Portugal
2019/03 - Current Jury member in a public tender for an Assistant Researcher contract (REQUIMTE 2018-46), within the framework of a project, PTDC/QUI-COL/30834/2017, financed by national funds through FCT / MCTES and the FEDER, through the COMPETE-Operational Competitiveness Factors Program (POFC) POCI-01-0145-FEDER-030834.
2018 - Current Jury member in a public tender for an Master's Research fellowship, within the framework of a project, PTDC/MAR-BIO/4694/2014, financed by national funds through FCT / MCTES and the FEDER, through the COMPETE-Operational Competitiveness Factors Program (POFC) POCI-01-0145-FEDER-016790.
2017/10 - Current Jury member in a public tender for a Research fellowship (Ref. ICETA 2017-34), under the project PTDC/MAR-BIO/4694/2014, with the financial support of FCT/MCTES through national funds and when applicable co-financed by the FEDER under the Partnership Agreement COMPETE 2020 Universidade do Porto Faculdade de Farmácia, Portugal
2024/10/02 - 2024/11/28 Member of the jury of the One Health Pet Awards promoted by the UPPartner, Lisbon. Evaluation of the categories "Health & Well-Being". https://onehealth-petawards.com/en/pet-awards-en/#panel

Scientific expedition

Activity description Institution / Organization
2023/10/17 - Current Short scientific mission to perform measurements using synchrotron-based infrared microspectroscopy at Alba Synchrotron. Barcelona, Spain. Alba Synchroton, Spain
2021/11/01 - 2021/11/06 Short scientific mission to perform measurements using synchrotron-based infrared microspectroscopy at Alba Synchrotron. Barcelona, Spain. Centro Universitario Internacional de Barcelona, Spain
2017/10/22 - 2017/11/26 Short scientific mission to perform measurement using synchrotron-based infrared microspectroscopy at Alba Synchrotron. Barcelona, Spain. Centro Universitario Internacional de Barcelona, Spain
Distinctions

Award

2024 Best poster presentation
2021 Best oral presentation ESB 2021
2020 Best Poster presentation award
2019 Best Oral Communication in Chemistry
Universidade do Porto, Portugal
2018 Best Oral Communication in Chemistry
2018 Best Poster Communication in Chemistry
2016 Best Poster, 11th Inorganic Chemistry Conference, Sintra, Portugal

Other distinction

2024 Distinção Mérito e Relevância nos One Health Pet Awards da UPPartner
2008 Postdoctoral fellowship (BPD/37880/2007)
Fundação para a Ciência e a Tecnologia, Portugal
2001 PhD fellowship (PRAXIS XXI BD/4613/2001)
Fundação para a Ciência e a Tecnologia, Portugal
1998 MSc fellowship (PRAXIS XXI BM/20357/98)
Fundação para a Ciência e a Tecnologia, Portugal