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Identification

Personal identification

Full name
Licínio Manuel Mendes Manco

Citation names

  • Manco, Licínio

Author identifiers

Ciência ID
001D-A03D-9F69
ORCID iD
0000-0002-2636-0288

Languages

Language Speaking Reading Writing Listening Peer-review
English Intermediate (B1) Advanced (C1) Advanced (C1) Intermediate (B1)
French Beginner (A1) Intermediate (B1) Intermediate (B1) Beginner (A1)
Spanish; Castilian Beginner (A1) Intermediate (B1) Intermediate (B1) Beginner (A1)
Education
Degree Classification
2003/02/28
Concluded
 Antropologia Biológica (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"A Deficiência em Piruvato-Quinase (PK) na População Portuguesa - Estudos de Genética Molecular e Populacional" (THESIS/DISSERTATION)
 Distinção e Louvor
1993
Concluded
 Biologia Celular (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Biotinidase, Pirimidina 5’-nucleotidase, Desoxirribonuclease II: Caracterização Electroforética" (THESIS/DISSERTATION)
 Muito Bom
1988
Concluded
 Licenciatura em Biologia (Ramo Científico) (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"n/a" (THESIS/DISSERTATION)
 14 valores
1985
Concluded
 Licenciatura em Biologia (Ramo Educacional) (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"n/a" (THESIS/DISSERTATION)
 15 valores
Affiliation

Science

Category
Host institution 		Employer
2007 - Current Researcher (Research) Universidade de Coimbra Centro de Investigação em Antropologia e Saúde, Portugal

Other Careers

Category
Host institution 		Employer
1990/01/01 - Current Técnico Superior (Técnico Superior) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
1985 - 1989 Professor do ensino básico e secundário (Professor do ensino básico e secundário) Ministério da Educação, Portugal
Projects

Grant

Designation Funders
2017/01/01 - 2021/04/01 DNA methylation as an age predictor in living and deceased individuals
SFRH/BD/117022/2016
Supervisor
Universidade de Coimbra Centro de Investigação em Antropologia e Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2015 - 2020 Obesity susceptibility genetic variants identified from recent whole-exome sequencing: Implications in an Iberian sample
SFRH/BPD/109043/2015
Supervisor
Fundação para a Ciência e a Tecnologia
Concluded
2011 - 2015/02 Study of genetic variants associated with obesity in Portuguese children
SFRH/BD/68774/2010
Supervisor
Universidade de Coimbra Centro de Investigação em Antropologia e Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2018/01/01 - 2022/12/31 Projeto estratégico - Centro de Investigação em Antropologia e Saúde (CIAS)
FCTPEst- OE/SADG/UID0283
Principal investigator
Universidade de Coimbra Centro de Investigação em Antropologia e Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Under evaluation
2015/01/01 - 2018/12/31 Projeto estratégico - Centro de Investigação em Antropologia e Saúde (CIAS)
FCT-PEst-OE/SADG/UI0283
Principal investigator
Universidade de Coimbra Centro de Investigação em Antropologia e Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2014/12/31 Strategic Project - CIAS UI 283
FCT-PEst-OE/SADG/UI0283
Universidade de Coimbra, Portugal

Universidade de Coimbra Centro de Investigação em Antropologia e Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/04/01 - 2014/09/30 Alterações nas Vias Glicolítica e Pentoses-Fosfato do eritrócito - como afectam a infecção por Plasmódio?
PTDC/SAU-MET/110323/2009
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/04/01 - 2014 Disorders on the Glycolytic and Pentose Phosphate Pathways of the Red Blood Cell - how do they affect Plasmodium infection?
info:eu-repo/grantAgreement/FCT/3599-PPCDT/110323/PT
Researcher
Concluded
2011/01/01 - 2012/12/31 Projecto Estratégico - LA 18 - 2011-2012
PEst-OE/SAU/LA0018/2011
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Albuquerque, David; Manco, Licínio; Nóbrega, Clévio. "Molecular Biology of Human Obesity: Non-epigenetics in Comparison with Epigenetic Processes". In Handbook of Nutrition, Diet, and Epigenetics, 1-18. Springer International Publishing, 2017.
    10.1007/978-3-319-31143-2_7-1
  2. David Albuquerque; Licínio Manco; Clévio Nóbrega. "Genetics of Human Obesity". In Obesity A Practical Guide, edited by Springer International Publishing, 87-101. 2016.
    Published • 10.1007/978-3-319-19821-7_7
  3. David Albuquerque; Licínio Manco; Clévio Nóbrega. "Epigenetics of Human Obesity: A Link Between Genetics and Nutrition". In Molecular Mechanisms Underpinning the Development of Obesity, edited by Springer, 101-127. 2014.
    Published • 10.1007/978-3-319-12766-8_8
Conference abstract
  1. Licínio Manco; Celeste Bento; Luís Relvas; Tabita M. Maia; M. Letícia Ribeiro. "BETA-GLOBIN GENE CLUSTER HAPLOTYPES ASSOCIATED WITH HBF VARIATION IN ¿-THALASSEMIA CARRIERS OF PORTUGUESE ORIGIN". Paper presented in 24th Congress of the European Hematology Association (EHA), 2019.
    Published
  2. Toste S, Relvas L, Bento C, Abade A, Ribeiro ML, Manco L. "Haplotype analysis of common HFE mutations in the portuguese population and association with iron overload". Paper presented in 18th Congress of the European Hematology Association, 2013.
  3. Pereira S, Relvas L, Bento C, Abade A, Ribeiro ML, Manco L. "BCL11A polymorphic variations influences fetal hemoglobin levels in portuguese subjects with common hereditary persistence of fetal hemoglobin". Paper presented in 18th Congress of the European Hematology Association, 2013.
  4. Manco L, Almaraz R, Sánchez R, Bento C, Corrons V, Ribeiro ML. "Hydrops fetalis in a pk-deficient patient homozygous for a pklr missense mutation in cis with a novel promoter nucleotide substitution.". Paper presented in 16th Annual Meeting of the European Hematology Association, 2011.
  5. L Manco, L Relvas, U Rebelo, J Vidán, M L Ribeiro. "A new small PKLR gene deletion associated with a missense mutation in a patient with pyruvate kinase deficiency and compensated hemolysis". Paper presented in 11th Congress of the European Hematology Association (EHA), 2006.
    Published
Conference poster
  1. Diana Alves, Selsabil Bouabdallah, Licínio Manco. "SUBLINEAGES OF THE Y-CHROMOSOME HAPLOGROUP E-M78 IN THE PORTUGUESE POPULATION". Paper presented in 27ª Reunião Anual da Sociedade Portuguesa de Genética Humana (SPGH), 2023.
  2. Queiroz, Guilherme; Celdidy Monteiro; Manco, Licínio; Luís Relvas; Maria de Jesus Trovoada; Leite, Andreia; Bento, Celeste. Corresponding author: Queiroz, Guilherme. "Sickle cell trait in São Tomé e Príncipe: a population-based prevalence study in women of reproductive age". Paper presented in 16th International Conference on Thalassaemia and Other Haemoglobinopathies, 2023.
  3. Nunes, Fábio; Manco, Licínio. "THE Y-CHROMOSOMAL HAPLOTYPE DIVERSITY OF R1B-M269 SUBHAPLOGROUPS IN INDIVIDUALS FROM THE CENTRAL REGION OF PORTUGAL". Paper presented in 27th Annual Meeting of Sociedade Portuguesa de Genética Humana (SPGH), 2023.
  4. Manco, Licínio; Queiroz, Guilherme; Bento, Celeste; Luís Relvas; De Jesus Trovoada, M.; Celdidy Monteiro. "Sickle Cell Trait prevalence in São Tomé e Príncipe: starting small to unleash sickle cell epidemiology in lusophone Africa". Paper presented in 18th Annual Sickle Cell & Thalassaemia Conference, 2023.
  5. Correia Dias, Helena; Manco, Licínio. "Droplet digital PCR for epigenetic age estimation using DNA methylation in ELOVL2 and PDE4C genes". Paper presented in 26ª Reunião Anual – SPGH, 2022.
  6. Nunes, Fábio; Manco, Licínio. "ANALYSIS OF R1B-M269 SUBHAPLOGROUS IN THE CENTRAL REGION OF PORTUGAL". Paper presented in 26 Annual Meeting of Sociedade Portuguesa de Genética Humana (SPGH), 2022.
  7. Manco, Licínio; Bento, Celeste; Luís Relvas; Maia, Tabita; Letícia Ribeiro, M.. "Association study of KLF1 gene variations with HbF and HbA2 levels in ß-thalassemia carriers of Portuguese origin". Paper presented in European Human Genetics Virtual Conference 2021, 2021.
  8. Manco, Licínio; Bento, Celeste; Luís Relvas; Maia, Tabita; Letícia Ribeiro, M.. "Molecular heterogeneity of Glucose-6-phosphate dehydrogenase (G6PD) deficiency in Portugal". Paper presented in EHA2021 Virtual Congress - 26th Congress of the European Hematology Association, 2021.
  9. Correia Dias, Helena; Cunha, Eugénia; Cordeiro, Cristina; Corte Real, Francisco; Manco, Licínio. "DNA methylation levels of the ELOVL2 locus for age prediction in living and deceased individuals". Paper presented in Symposium on Humanitarian Forensic Action: Forensic Best Practices and Principles for Preventing and Resolving the Missing, 2019.
  10. Correia Dias, Helena; Cunha, Eugénia; Cordeiro, Cristina; Corte Real, Francisco; Manco, Licínio. "Avaliação dos níveis de metilação de DNA do gene ELOVL2 em diferentes tecidos de indivíduos vivos e mortos". Paper presented in 18º Congresso Nacional de Medicina Legal e Ciências Forenses, 2019.
  11. Correia Dias, Helena; Pereira, Janet; Pinto, Catarina; Cunha, Eugénia; Corte Real, Francisco; Manco, Licínio. "A multiplex DNA methylation SNaPshot assay for age prediction using blood samples: a replication study". Paper presented in 23ª Reunião da Sociedade Portuguesa de Genética Humana (SPGH), 2019.
  12. Manco, Licínio; Bento, Celeste; Luís Relvas; Maia, Tabita; Letícia Ribeiro, M.. "MODELOS MULTILOCUS PARA EVALUAR ASOCIACIONES GENÉTICAS CON LA VARIACIÓN DE HbF EN PORTADORES DE BETA-TALASEMIA DE ORIGEN PORTUGUESA". Paper presented in LXI Congreso Nacional de la Sociedad Española de Hematología y Hemoterapia SEEH, 2019.
  13. Correia Dias, Helena; Cunha, Eugénia; Cordeiro, Cristina; Corte Real, Francisco; Manco, Licínio. "Examination of DNA methylation levels of the ELOVL2 locus in several samples from living and deceased individuals". Paper presented in Ciência 2019- Encontro de Ciência e Tecnologia em Portugal, 2019.
  14. Correia Dias, Helena; Cordeiro, Cristina; Cunha, Eugénia; Corte Real, Francisco; Manco, Licínio. "Using DNA methylation for age estimation in blood samples of deceased individuals". Paper presented in Scientific Conference: International conferences on Forensic Science Eduction and Training na Universidade de Aveiro, 2019.
  15. Correia Dias, Helena; Cunha, Eugénia; Corte Real, Francisco; Manco, Licínio. "DNA methylation patterns in loci ELOVL2, FHL2, EDARADD and PDE4C could improve age estimations in forensic contexts". Paper presented in 17º Congresso Nacional de Medicina Legal e Ciências Forenses, 2018.
  16. Licínio Manco; Celeste Bento; Luís Relvas; M. Letícia Ribeiro. "HAPLOTIPOS DEL CLUSTER BETA-GLOBINICO ASOCIADOS CON LA VARIACIÓN DE LA HBF EN PORTADORES DE ETA-TALASEMIA DE ORIGEN PORTUGUESA.". Paper presented in LXI Congreso Nacional de la Sociedad Española de Hematología y Hemoterapia SEEH, 2018.
  17. Correia Dias, Helena; Cunha, Eugénia; Corte Real, Francisco; Manco, Licínio. "DNA methylation analysis on the basis of bisulfite-PCR sequencing: a useful age predictor tool". Paper presented in Ciência 2018- Encontro de Ciência e Tecnologia em Portugal, 2018.
  18. Simão Pinho, Cristina Padez, Licínio Manco. "Highest number of AMY1 copy number suggest to protect against obesity risk in Portuguese young adults: a preliminary study". Paper presented in 21ª Reunião Anual da Sociedade Portuguesa de Genética Humana (SPGH), 2017.
  19. Correia Dias, Helena; Cunha, Eugénia; Corte Real, Francisco; Manco, Licínio. "Analysing DNA methylation levels of the age predictor gene EDARADD using the bisulfite PCR-sequencing method". Paper presented in 1 st International Caparica Conference in Translational Forensics, na Caparica (Portugal), 2017.
  20. Correia Dias, Helena; Cunha, Eugénia; Corte Real, Francisco; Manco, Licínio. "Evaluating the DNA methylation patterns of ELOVL2 gene based on the bisulfite PCR-sequencing: a useful method for human age prediction". Paper presented in 16º Congresso Nacional de Medicina Legal e Ciências Forenses, 2017.
  21. Correia Dias, Helena; Cunha, Eugénia; Corte Real, Francisco; Manco, Licínio. "Bisulfite PCR-sequencing as a method to evaluate the DNA methylation patterns of the age predictor gene ELOVL2". Paper presented in 21ª Reunião da Sociedade Portuguesa de Genética Humana (SPGH), na Caparica (Portugal), 2017.
  22. L. Manco, C. Silva, P. Martinho, T. Fidalgo, A.B. Sarmento, M.L. Ribeiro. "A STUDY OF VENOUS THROMBOEMBOLISM SUSCEPTIBILITY LOCI FACTOR XI, ABO AND FIBRINOGEN IN A PORTUGUESE POPULATION SAMPLE". Paper presented in 22nd Congress of the European Hematology Association (EHA), 2017.
  23. Licínio Manco; Celeste Bento; Luís Relvas; A. Estevam; J Albuquerque; M. Letícia Ribeiro. "Association study of polymorphic variations with haemoglobin A2 levels in beta-thalassemia carriers.". Paper presented in The European Human Genetics Conference 2017, 2017.
  24. Albuquerque D, Gimeno Ferrer F, Manco L, Marcaida Benito G, Rodríguez-López R. "Validation of genetic risk score predicting obesity in adults: Preliminary results". 2017.
  25. Manco L; Martinho P; Fidalgo T; Silva C; Oliveira AC; Salvado R; Ribeiro ML. "ESTUDIO DE ASOCIACIÓN ENTRE LOS SNPS F11 rs2036914 Y ABO rs2519093 Y LA ENFERMEDAD TROMBOEMBÓLICA VENOSA EN UNA MUESTRA DE POBLACIÓN PORTUGUESA". Paper presented in LVIII CONGRESO NACIONAL SEHH-XXXII CONGRESO NACIONAL SEHH, 2016.
  26. L. Manco, A. Soares, S. N. Wasterlain. "Association of SLC6A4 genotypes with antisocial behavior in response to childhood environment: a study in young adults supporting the hypothesis that 5-HTTLPR is a genetic marker of differential susceptibility". Paper presented in European Human Genetics Conference 2016, 2016.
  27. M. Alvarez, P. Pereira, L. Manco, S. Cherpe, M. Cunha, J. Pinto Gouveia, P.G. Mota. "Association of serotonin transporter gene polymorphisms (5-HTTLPR and rs 25531) and life-histories with psychopathology vulnerability profiles: a study performed with healthy young adults". Paper presented in European Human Genetics Conference 2016, 2016.
  28. Del Orbe Barreto, R; Arrizabalaga, B; De la Hoz Ana, B; Tejada, I; Aragües, P; Silva, C; Almeida, H; Fidalgo, T; Bento,. "UTILIDAD DE LA NEXT GENERATION SEQUENCING EN LA OPTIMIZACIÓN DEL DIAGNÓSTICO DE LAS ANEMIAS HEMOLÍTICAS CONGÉNITAS". Paper presented in LVII Congreso Nacional de la SEHH y XXXI Congreso Nacional de la SETH, 2015.
  29. Dias, Helena; Muc, Magdalena; Padez, Cristina; Manco, Licínio. "Association of the lactase -13910C>T polymorphism (rs4988235) with BMI and fat-mass in a sample of students from the University of Coimbra, Portugal". Paper presented in BioAnthropological Meeting (BAM), 2015.
  30. Albuquerque, D; Nóbrega, C; Manco, L. "Association between obesity and polymorphisms in FTO, HOB5, LCT, MC4R, MSRA, NRXN3, OLFM4, PPARGC1A, SEC16B, TFAP2B and TMEM18 genes among Portuguese children". Paper presented in 21st European Congress on Obesity (ECO2014), 2014.
  31. Manco L, Pereira C, Bento C, Abade A, Ribeiro ML. "Polimorfismos genéticos asociados a aumento de HBF em portadores de beta-talassemia". Paper presented in LV Congreso Nacional de la Sociedad Espanola de Hematologia Y Hemoterapia, 2013.
  32. Albuquerque, D; Nóbrega, C; Manco, L. "Associação do polimorfismo -13910C>T à obesidade abdominal em crianças portuguesas". Paper presented in 16º Congresso Português de Obesidade, 2012.
  33. M. Horta, M. Coucelo, L. Manco, A.C. Oliveira, C. Bento, M.L. Ribeiro. "ASOCIACIÓN ENTRE EL SNP RS12343867 (C/T) Y LA ADQUISICIÓN DE LA MUTACIÓN JAK2V671F EN NEOPLASIAS MIELOPROLIFERATIVAS". Paper presented in LIV Reunión Nacional de la SEHH, 2012.
  34. Manco L, Pereira C, Relvas L, Bento C, Ribeiro ML. "INFLUENCE OF HBG2 XMNI POLYMORPHISM ON HBF LEVELS IN PORTUGUESE BETA-THALASSEMIA CARRIERS". Paper presented in 19th Congress of the European Hematology Association, 2012.
  35. Albuquerque, D; Jacobs, J; Hanen, S; Nóbrega, C; Manco, L. "The common rs9939609 polymorphism of the Fat Mass and Obesity-associated (FTO) gene is associated with obesity in Portuguese children". Paper presented in 19th European Congress on Obesity (ECO2012), 2012.
  36. Manco L, Relvas L, Rebelo U, Murga MJ, Santos A, Yanez L, Bento C, and Ribeiro ML. "Four novel PKLR gene mutations in association with pyruvate kinase (PK) deficiency". Paper presented in 15th Annual Meeting of the European-Hematology-Association, 2010.
  37. Licínio Manco, Janet Pereira, Umbelina Rebelo, Celeste Bento, Jaspal Kaeda, M. Letícia Ribeiro. "Discordant HUMARA and G6PD mRNA assays in a female with chronic haemolytic anaemia due to novel type I G6PD variant". Paper presented in European Association for Red Cell Research-EARCR, 2009.
  38. Licínio Manco, J.M. Vagace, Luís Relvas, Umbelina Rebelo, Celeste Bento, M. Letícia Ribeiro. "Chronic hemolytic anemia due to Pyruvate Kinase (PK) deficiency in a patient heterozygous for Haemoglobin S and no clinical features of Sickle Cell Disease". Paper presented in European Association for Red Cell Research-EARCR, 2009.
  39. Licínio Manco, Celeste Bento, Janet Pereira, Luís Relvas, Umbelina Rebelo, M. Letícia Ribeiro. "Genetics of red blood cell enzyme deficiencies in Portugal: mutation profile on PK, G6PD, P5’N and TPI deficiencies". Paper presented in 4th European Conference on Rare Diseases, November, 2007.
  40. L Manco, Pereira J, Vidán J, Azevedo J, Rebelo U, Crisostomo A, Ribeiro ML. "G6PD Tondela: a new class I variant due to 18 nucleotides deletion in exon 10". Paper presented in 12nd Congress of the European Hematology Association (EHA), 2007.
  41. L Manco, Vidán J, Relvas L, Azevedo J, Neves F, Ribeiro ML. "Triose-phosphate isomerise deficiency: molecular studies in two patients". Paper presented in 12nd Congress of the European Hematology Association (EHA), 2007.
  42. L. Manco, C. Silva Pinto, J Pereira, M.C. Bento, H. Vazão, M.L. Ribeiro. "Molecular characterisation of four Portuguese patients with Pyrimidine 5’-nucleotidase haemolytic anaemia". Paper presented in 10th Congress of the European Hematology Association, 2005.
  43. L Manco, MC Bento, G Jesus, C Seabra, C Geraldes, ML Ribeiro, G Tamagnini. "G6PD Covão do Lobo – Una nueva mutación asociada a anemia hemolítica crónica no-esferocítica". Paper presented in XLVI Reunión Nacional AEHH y XX Congreso Nacional SETH - Valencia (Espanha), 2004.
  44. RIBEIRO ML, ALMEIDA H, MANCO L, RELVAS L, REBELO U, MACIEIRA L, FERREIRA F, TAMAGNINI G. "Anemia hemolítica por défice de piruvato-kinase associada a uma eliptocitose hereditária". Paper presented in 2ª Reunião da Sociedade Portuguesa de Genética Humana (SPGH), 1998.
  45. MANCO L, RIBEIRO ML, AMORIM A, ABADE A. "Estudo do STR (ATT)n do gene PK-LR na população da região centro de Portugal e em deficientes de PK". Paper presented in 2ª Reunião da Sociedade Portuguesa de Genética Humana (SPGH), 1998.
  46. MANCO L, RIBEIRO ML, TAMAGNINI G, ABADE A, VIANA A. "Novel Mutations at PKLR Gene in Pyruvate Kinase (PK) Deficient Portuguese Patients". Paper presented in 30th Annual Meeting of the European Society of Human Genetics, 1998.
  47. MANCO L, RIBEIRO ML, TAMAGNINI G, ABADE A. "Caracterização Molecular do gene PKLR em doentes deficientes em Piruvato-Kinase (PK) naturais de Portugal e da República Checa". Paper presented in Poster apresentado à 1ª Reunião da Sociedade Portuguesa de Genética Humana (SPGH), 1997.
Edited book
  1. Santos, Ana Luísa; Gama, Augusta; Padez, Cristina; Manco, Licínio; Ferrão, Maria Miguel; Marques, Vitor Rosado; Matos, Vítor. Anthropology and Health: trends for the next decades. Program - Abstracts. 18th-19th November 2010. Coimbra, Portugal: Centro de Investigação em Antropologia e Saúde, Universidade de Coimbra. 2010.
    Published
Journal article
  1. Bouabdallah, Selsabil; Alves, Diana; Manco, Licínio. "Analysis of Human Y Chromosome Haplogroup E-M81 Sublineages in Portuguese Samples". Human Biology (2024): http://dx.doi.org/10.1353/hub.2017.a931433.
    10.1353/hub.2017.a931433
  2. Queiroz, Guilherme; Monteiro, Celdidy; Manco, Licínio; Relvas, Luís; Trovoada, Maria de Jesus; Leite, Andreia; Bento, Celeste. "Sickle cell trait in São Tomé e Príncipe: a population-based prevalence study in women of reproductive age". BMC Public Health 24 1 (2024): http://dx.doi.org/10.1186/s12889-024-17761-1.
    10.1186/s12889-024-17761-1
  3. Dias, Helena Correia; Manco, Licínio. "Predicting age from blood by droplet digital PCR using a set of three DNA methylation markers". Forensic Science International 356 (2024): 111950. http://dx.doi.org/10.1016/j.forsciint.2024.111950.
    Published • 10.1016/j.forsciint.2024.111950
  4. Licínio Manco; David Albuquerque; Beatriz Aranda; Daniela Rodrigues; Aristides M. Machado-Rodrigues; Cristina Padez. "Differential sex-association between PCSK1 polymorphisms and obesity risk in Portuguese children". American Journal of Human Biology (2023): https://doi.org/10.1002/ajhb.24023.
    10.1002/ajhb.24023
  5. Licínio Manco; David Albuquerque; Daniela Rodrigues; Aristides M. Machado-Rodrigues; Cristina Padez. "Protective Association of APOC1/rs4420638 with Risk of Obesity: A case-control Study in Portuguese Children". Biochemical Genetics (2023): http://dx.doi.org/10.1007/s10528-023-10427-4.
    10.1007/s10528-023-10427-4
  6. Videira-Silva; Licínio Manco; Sardinha, LB; Helena Fonseca. "Vigorous physical activity: A potential ally in adolescent obesity management". European Journal of Sport Science (2023): http://dx.doi.org/10.1080/17461391.2022.2035437.
    10.1080/17461391.2022.2035437
  7. Licínio Manco; Janet Pereira; Teresa Fidalgo; Marina Cunha; José Pinto-Gouveia; Cristina Padez; Lara Palmeira. "Next-generation sequencing of 12 obesity genes in a Portuguese cohort of patients with overweight and obesity". European Journal of Medical Genetics (2023): https://doi.org/10.1016/j.ejmg.2023.104728.
    10.1016/j.ejmg.2023.104728
  8. Manco, Licínio; Bento, Celeste; Relvas, Luís; Maia, Tabita; Ribeiro, Maria Letícia. "Heterogeneidade Molecular da Deficiência em Glicose-6-Fosfato Desidrogenase (G6PD) na População Portuguesa". Acta Médica Portuguesa (2022): http://dx.doi.org/10.20344/amp.17584.
    10.20344/amp.17584
  9. Helena Correia Dias; Eugénia Cunha; Francisco Corte Real; Licínio Manco. "Challenges and (Un)Certainties for DNAm Age Estimation in Future". Forensic Sciences (2022): https://doi.org/10.3390/forensicsci2030044.
    10.3390/forensicsci2030044
  10. Licínio Manco; Raquel Santos; Catarina Rocha; Luís Relvas; Celeste Bento; Tabita Maia; Verónica Gomes; António Amorim; Maria J. Prata. "Hb F Levels in ß-Thalassemia Carriers and Normal Individuals: Known and Unknown Quantitative Trait Loci in the ß-Globin Gene Cluster". Hemoglobin (2022): https://doi.org/10.1080/03630269.2022.2070498.
    10.1080/03630269.2022.2070498
  11. Licínio Manco; Helena Correia Dias. "DNA methylation analysis of ELOVL2 gene using droplet digital PCR for age estimation purposes". Forensic Science International (2022): http://dx.doi.org/10.1016/j.forsciint.2022.111206.
    10.1016/j.forsciint.2022.111206
  12. Martin Kirschner; Inga Rebecca Heinen; Steffen Koschmieder; Licinio Manco; Celeste Bento; Thomas Eggermann; Ingo Kurth; et al. "Novel homozygous nonsense mutation in the P5'N-1 coding gene as an alternative cause for hereditary anemia with basophilic stippling". Clinical Case Reports (2022): http://dx.doi.org/10.1002/ccr3.5501.
    10.1002/ccr3.5501
  13. Helena Correia Dias; Licínio Manco; Francisco Corte Real; Eugénia Cunha. "A Blood–Bone–Tooth Model for Age Prediction in Forensic Contexts". Biology (2021): https://doi.org/10.3390/biology10121312.
    10.3390/biology10121312
  14. Helena Correia Dias; Eugénia Cunha; Francisco Corte Real; Licínio Manco. "Age prediction in living: Forensic epigenetic age estimation based on blood samples". Legal Medicine (2020): http://dx.doi.org/10.1016/j.legalmed.2020.101763.
    10.1016/j.legalmed.2020.101763
  15. Helena Correia Dias; Francisco Corte-Real; Eugénia Cunha; Licínio Manco. "DNA methylation age estimation from human bone and teeth". Australian Journal of Forensic Sciences (2020): 1-14. https://doi.org/10.1080/00450618.2020.1805011.
    10.1080/00450618.2020.1805011
  16. Licínio Manco; Aristides M. Machado-Rodrigues; Cristina Padez. "Association study of common functional genetic polymorphisms in SLC6A4 (5-HTT) and MAOA genes with obesity in portuguese children". Archives of Physiology and Biochemistry (2020): 1-6. https://doi.org/10.1080/13813455.2020.1779312.
    10.1080/13813455.2020.1779312
  17. Dias, Helena Correia; Cordeiro, Cristina; Pereira, Janet; Pinto, Catarina; Real, Francisco Corte; Cunha, Eugénia; Manco, Licínio. "DNA methylation age estimation in blood samples of living and deceased individuals using a multiplex SNaPshot assay". Forensic Science International 311 (2020): 110267. http://dx.doi.org/10.1016/j.forsciint.2020.110267.
    10.1016/j.forsciint.2020.110267
  18. Licínio Manco; Celeste Bento; Luís Relvas; Elisabete Cunha; Janet Pereira; Valeria Moreira; Manuela Alvarez; Tabita Maia; M. Letícia Ribeiro. "Multi-Locus Models to Address Hb F Variability in Portuguese ß-Thalassemia Carriers". Hemoglobin (2020): https://doi.org/10.1080/03630269.2020.1753766.
    10.1080/03630269.2020.1753766
  19. Helena Correia Dias; Cristina Cordeiro; Francisco Corte Real; Eugénia Cunha; Licínio Manco. "Age Estimation Based on DNA Methylation Using Blood Samples From Deceased Individuals". Journal of Forensic Sciences (2020): https://doi.org/10.1111/1556-4029.14185.
    10.1111/1556-4029.14185
  20. Manco, Licínio; Pinho, Simão; Albuquerque, David; Machado-Rodrigues, Aristides M.; Padez, Cristina. "Physical activity and the association between the FTO rs9939609 polymorphism and obesity in Portuguese children aged 3 to 11¿years". American Journal of Human Biology 31 6 (2019): http://dx.doi.org/10.1002/ajhb.23312.
    10.1002/ajhb.23312
  21. Manco, L.; Bento, C.; Relvas, L.; Maia, T.; Ribeiro, M. L.. "BETA-GLOBIN GENE CLUSTER HAPLOTYPES ASSOCIATED WITH HBF VARIATION IN ß-THALASSEMIA CARRIERS OF PORTUGUESE ORIGIN". HemaSphere 3 (2019): 1068. http://dx.doi.org/10.1097/01.hs9.0000568072.95453.e7.
    10.1097/01.hs9.0000568072.95453.e7
  22. Lara Palmeira; Marina Cunha; Cristina Padez; Manuela Alvarez; José Pinto-Gouveia; Licínio Manco. "Association study of variants in genes FTO, SLC6A4, DRD2, BDNF and GHRL with binge eating disorder (BED) in Portuguese women". Psychiatry Research 273 (2019): 309-311. https://doi.org/10.1016/j.psychres.2019.01.047.
    10.1016/j.psychres.2019.01.047
  23. David Albuquerque; Luz Maria González; Fátima Gimeno Ferrer; Marcos Bruna; Carlos Sánchez; Goitzane Marcaida Benito; Raquel Rodríguez-López; Licínio Manco. "Association study of six single nucleotide polymorphisms with obesity in two independent Iberian samples". Meta Gene 17 (2018): 17-22. https://doi.org/10.1016/j.mgene.2018.04.006.
    10.1016/j.mgene.2018.04.006
  24. Licínio Manco; Catarina Silva; Teresa Fidalgo; Patrícia Martinho; Ana B. Sarmento; M. Letícia Ribeiro. "Venous thromboembolism risk associated with ABO, F11 and FGG loci". Blood Coagulation & Fibrinolysis (2018): http://dx.doi.org/10.1097/mbc.0000000000000753.
    10.1097/mbc.0000000000000753
  25. Simão Pinho; Cristina Padez; Licínio Manco. "High AMY1 copy number protects against obesity in Portuguese young adults". Annals of Human Biology 45 5 (2018): 435-439. https://doi.org/10.1080/03014460.2018.1490452.
    10.1080/03014460.2018.1490452
  26. Licínio Manco; Joana Albuquerque; Maria Francisca Sousa; Rui Martiniano; Ricardo Costa de Oliveira; Sofia Marques; Verónica Gomes; et al. "The Eastern side of the Westernmost Europeans: Insights from subclades within Y-chromosome haplogroup J-M304". American Journal of Human Biology 30 2 (2018): e23082-e23082. https://doi.org/10.1002/ajhb.23082.
    10.1002/ajhb.23082
  27. Manco, Licínio. "The contribution of genetics and environment to obesity.". British medical bulletin (2017): http://europepmc.org/abstract/med/28910990.
    10.1093/bmb/ldx022
  28. Manco, Licínio. "The population genomics of archaeological transition in west Iberia: Investigation of ancient substructure using imputation and haplotype-based methods.". PLoS genetics (2017): http://europepmc.org/abstract/med/28749934.
    10.1371/journal.pgen.1006852
  29. Fidalgo, Teresa; Martinho, Patrícia; Pinto, Catarina S.; Oliveira, Ana C.; Salvado, Ramon; Borràs, Nina; Coucelo, Margarida; et al. "Combined study of ADAMTS13 and complement genes in the diagnosis of thrombotic microangiopathies using next-generation sequencing". Research and Practice in Thrombosis and Haemostasis 1 1 (2017): 69-80. http://dx.doi.org/10.1002/rth2.12016.
    10.1002/rth2.12016
  30. Manco, Licínio. "Polymorphisms in the SNRPN gene are associated with obesity susceptibility in a Spanish population.". The journal of gene medicine (2017): http://europepmc.org/abstract/med/28387446.
    10.1002/jgm.2956
  31. Manco, Licínio. "Molecular basis of pyruvate kinase deficiency among Tunisians: description of new mutations affecting coding and noncoding regions in the PKLR gene.". International journal of laboratory hematology (2017): http://europepmc.org/abstract/med/28133914.
    10.1111/ijlh.12610
  32. Manco, Licínio. "The lactase -13910C>T polymorphism (rs4988235) is associated with overweight/obesity and obesity-related variables in a population sample of Portuguese young adults.". European journal of clinical nutrition (2017): http://europepmc.org/abstract/med/27577176.
    10.1038/ejcn.2016.164
  33. Manco, Licínio. "Association of 5-HTTLPR genotypes with antisocial behavior in response to childhood environment: A study in young adults of Portuguese origin.". Psychiatry research (2017): http://europepmc.org/abstract/med/28069247.
    10.1016/j.psychres.2017.01.001
  34. Manco, Licínio. "Detection of new pathogenic mutations in patients with congenital haemolytic anaemia using next-generation sequencing.". International journal of laboratory hematology (2016): http://europepmc.org/abstract/med/27427187.
    10.1111/ijlh.12551
  35. Licínio Manco; Magdalena Muc; Cristina Padez. "Association study between near-MC4R variants and obesity-related variables in Portuguese young adults". Gene Reports 5 (2016): 98-101. https://doi.org/10.1016%2Fj.genrep.2016.09.011.
    10.1016/j.genrep.2016.09.011
  36. Licínio Manco; Celeste Bento; Bruno L. Victor; Janet Pereira; Luís Relvas; Rui M. Brito; Carlos Seabra; Tabita M. Maia; M. Letícia Ribeiro. "Hereditary nonspherocytic hemolytic anemia caused by red cell glucose-6-phosphate isomerase (GPI) deficiency in two Portuguese patients: Clinical features and molecular study". Blood Cells, Molecules, and Diseases 60 (2016): 18-23. https://doi.org/10.1016/j.bcmd.2016.06.002.
    10.1016/j.bcmd.2016.06.002
  37. Manco, Licínio. "Congenital dyserythropoietic anemia associated to a GATA1 mutation aggravated by pyruvate kinase deficiency.". Annals of hematology (2016): http://europepmc.org/abstract/med/27342114.
    10.1007/s00277-016-2720-0
  38. Alvarez, Maria; Manco, Licínio. "Association of serotonin transporter gene polymorphisms (5-HTTLPR and rs 25531) and life-histories with psychopathology vulnerability profiles: a study performed with healthy young adults". Proc of European Human Genetics Conference 24 (2016): https://www.eshg.org/fileadmin/www.eshg.org/conferences/2016/downloads/ESHG2016_Abstracts_final.pdf.
  39. Manco, Licínio. "Severe neonatal jaundice due to a de novo glucose-6-phosphate dehydrogenase deficient mutation.". International journal of laboratory hematology (2016): http://europepmc.org/abstract/med/26693676.
    10.1111/ijlh.12455
  40. Manco, Licínio. "Association of polymorphisms in 5-HTT (SLC6A4) and MAOA genes with measures of obesity in young adults of Portuguese origin.". Archives of physiology and biochemistry (2016): http://europepmc.org/abstract/med/26698543.
    10.3109/13813455.2015.1111390
  41. Albuquerque D; Stice E; Rodríguez-López R; Manco L; Nóbrega C. "Current review of genetics of human obesity: from molecular mechanisms to an evolutionary perspective.". (2015): http://europepmc.org/abstract/med/25749980.
    10.1007/s00438-015-1015-9
  42. SANDRA TOSTE; LUÍS RELVAS; CATARINA PINTO; CELESTE BENTO; AUGUSTO ABADE; M. LETÍCIA RIBEIRO; LICÍNIO MANCO; et al. "Intragenic haplotype analysis of common HFE mutations in the Portuguese population". J Genet 94 2 (2015): 329-333. http://dx.doi.org/10.1007/s12041-015-0510-4.
    10.1007/s12041-015-0510-4
  43. Guerra M; Machado P; Manco L; Fernandes N; Miranda J; Arez AP. "Triosephosphate isomerase gene promoter variation: -5G/A and -8G/A polymorphisms in clinical malaria groups in two African populations.". (2015): http://europepmc.org/abstract/med/25801609.
    10.1016/j.meegid.2015.03.020
  44. Pereira C; Relvas L; Bento C; Abade A; Ribeiro ML; Manco L. "Polymorphic variations influencing fetal hemoglobin levels: association study in beta-thalassemia carriers and in normal individuals of Portuguese origin.". (2015): http://europepmc.org/abstract/med/25842369.
    10.1016/j.bcmd.2015.02.001
  45. Muc M; Padez C; Manco L. "Influence of physical activity on the association between the FTO variant rs9939609 and adiposity in young adults.". (2015): http://europepmc.org/abstract/med/25809737.
    10.1002/ajhb.22712
  46. Fidalgo T; Martinho P; Salvado R; Manco L; Oliveira AC; Pinto CS; Gonçalves E; et al. "Familial thrombotic risk based on the genetic background of Protein C Deficiency in a Portuguese Study.". (2014): http://europepmc.org/abstract/med/25533856.
  47. Albuquerque, D.; Estévez, M.N.; Víbora, P.B.; Giralt, P.S.; Balsera, A.M.; Cortés, P.G.; López, M.J.; et al. "Novel variants in the MC4R and LEPR genes among severely obese children from the iberian population". Annals of Human Genetics 78 3 (2014): 195-207. http://www.scopus.com/inward/record.url?eid=2-s2.0-84897962855&partnerID=MN8TOARS.
    10.1111/ahg.12058
  48. Albuquerque, D.; Nóbrega, C.; Rodríguez-López, R.; Manco, L.. "Association study of common polymorphisms in MSRA, TFAP2B, MC4R, NRXN3, PPARGC1A, TMEM18, SEC16B, HOXB5 and OLFM4 genes with obesity-related traits among Portuguese children". Journal of Human Genetics 59 6 (2014): 307-313. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903142156&partnerID=MN8TOARS.
    10.1038/jhg.2014.23
  49. Machado P; Vaz TR; Nogueira F; Rodrigues J; Manco L; Ribeiro L; Bergstrom E; et al. "Quantitative proteomics for the analysis of Plasmodium falciparum and its red blood cell host - a preliminary study.". (2014): http://europepmc.org/abstract/PMC/PMC4179439.
    doi:10.1186/1475-2875-13-S1-P74
  50. Martiniano, R.; Feitosa, Y.; Abade, A.; Manco, L.. "Y-chromosome diversity in central Portugal reveals signatures of ancient maritime expansions". Anthropologischer Anzeiger 70 4 (2013): 355-367. http://www.scopus.com/inward/record.url?eid=2-s2.0-84892839616&partnerID=MN8TOARS.
    10.1127/0003-5548/2013/0321
  51. Albuquerque, D.; Nóbrega, C.; Manco, L.. "Association of FTO Polymorphisms with Obesity and Obesity-Related Outcomes in Portuguese Children". PLoS ONE 8 1 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84872314505&partnerID=MN8TOARS.
    10.1371/journal.pone.0054370
  52. Albuquerque, D.; Nõbrega, C.; Manco, L.. "The lactase persistence -13910C>T polymorphism shows indication of association with abdominal obesity among Portuguese children". Acta Paediatrica, International Journal of Paediatrics 102 4 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84875275313&partnerID=MN8TOARS.
    10.1111/apa.12134
  53. Manco, L.; Pires, S.; Lopes, A.I.; Figueiredo, I.; Albuquerque, D.; Alvarez, M.; Rocha, J.; Abade, A.. "Distribution of the-13910C>T polymorphism in the general population of Portugal and in subjects with gastrointestinal complaints associated with milk consumption". Annals of Human Biology 40 2 (2013): 205-208. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875724423&partnerID=MN8TOARS.
    10.3109/03014460.2012.754943
  54. Millimono, T.S.; Loua, K.M.; Rath, S.L.; Relvas, L.; Bento, C.; Diakite, M.; Jarvis, M.; et al. "High prevalence of hemoglobin disorders and glucose-6-phosphate dehydrogenase (G6PD) deficiency in the Republic of Guinea (West Africa)". Hemoglobin 36 1 (2012): 25-37. http://www.scopus.com/inward/record.url?eid=2-s2.0-84855679903&partnerID=MN8TOARS.
    10.3109/03630269.2011.600491
  55. Manco, Licínio. "Assessment of obesity and abdominal obesity among Portuguese children.". Acta medica portuguesa (2012): http://europepmc.org/abstract/med/23069237.
  56. Albuquerque, D.; Nóbrega, C.; Samouda, H.; Manco, L.. "Assessment of obesity and abdominal obesity among Portuguese children | Avaliação da obesidade e obesidade abdominal em crianças Portuguesas". Acta Medica Portuguesa 25 3 (2012): 169-173. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866904803&partnerID=MN8TOARS.
  57. Machado, P.; Manco, L.; Gomes, C.; Mendes, C.; Fernandes, N.; Salomé, G.; Sitoe, L.; et al. "Pyruvate Kinase Deficiency in Sub-Saharan Africa: Identification of a Highly Frequent Missense Mutation (G829A;Glu277Lys) and Association with Malaria". PLoS ONE 7 10 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84867630305&partnerID=MN8TOARS.
    10.1371/journal.pone.0047071
  58. Albuquerque, D.; Manco, L.; Loua, K.M.; Arez, A.P.; De Jesus Trovoada, M.; Relvas, L.; Millimono, T.S.; et al. "SLC40A1 Q248H allele frequencies and associated SLC40A1 haplotypes in three West African population samples". Annals of Human Biology 38 3 (2011): 378-381. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953084701&partnerID=MN8TOARS.
    10.3109/03014460.2010.541496
  59. Manco, L.; Pereira, J.; Relvas, L.; Rebelo, U.; Crisóstomo, A.I.; Bento, C.; Ribeiro, M.L.. "Chronic hemolytic anemia is associated with a new glucose-6-phosphate dehydrogenase in-frame deletion in an older woman". Blood Cells, Molecules, and Diseases 46 4 (2011): 288-293. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953687932&partnerID=MN8TOARS.
    10.1016/j.bcmd.2011.02.001
  60. Manco, L.; Silva, I.; Arede, P.; Trovoada, M.J.; Abade, A.; Alvarez, M.. "Allele frequencies of 6 STR loci (TH01, TPOX, CSF1PO, D13S317, D16S539 and D7S820) in São Tomé e Prín-cipe (West Africa)". Antropologia Portuguesa 28 (2011): 189-195. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874458902&partnerID=MN8TOARS.
  61. Serdaroglu, G.; Aydinok, Y.; Yilmaz, S.; Manco, L.; Özer, E.. "Triosephosphate isomerase deficiency: A patient with Val231Met mutation". Pediatric Neurology 44 2 (2011): 139-142. http://www.scopus.com/inward/record.url?eid=2-s2.0-79251587232&partnerID=MN8TOARS.
    10.1016/j.pediatrneurol.2010.08.016
  62. Manco, L.; Vagace, J.M.; Relvas, L.; Rebelo, U.; Bento, C.; Villegas, A.; Letícia Ribeiro, M.. "Chronic haemolytic anaemia because of pyruvate kinase (PK) deficiency in a child heterozygous for haemoglobin S and no clinical features of sickle cell disease". European Journal of Haematology 84 1 (2010): 89-90. http://www.scopus.com/inward/record.url?eid=2-s2.0-72449211102&partnerID=MN8TOARS.
    10.1111/j.1600-0609.2009.01353.x
  63. Nogueiro, I.; Manco, L.; Gomes, V.; Amorim, A.; Gusmão, L.. "Phylogeographic analysis of paternal lineages in NE Portuguese Jewish communities". American Journal of Physical Anthropology 141 3 (2010): 373-381. http://www.scopus.com/inward/record.url?eid=2-s2.0-76149145352&partnerID=MN8TOARS.
    10.1002/ajpa.21154
  64. Alves, J.; Machado, P.; Silva, J.; Gonçalves, N.; Ribeiro, L.; Faustino, P.; do Rosário, V.E.; et al. "Analysis of malaria associated genetic traits in Cabo Verde, a melting pot of European and sub Saharan settlers". Blood Cells, Molecules, and Diseases 44 1 (2010): 62-68. http://www.scopus.com/inward/record.url?eid=2-s2.0-73049117449&partnerID=MN8TOARS.
    10.1016/j.bcmd.2009.09.008
  65. MacHado, P.; Pereira, R.; Rocha, A.M.; Manco, L.; Fernandes, N.; Miranda, J.; Ribeiro, L.; et al. "Malaria: Looking for selection signatures in the human PKLR gene region". British Journal of Haematology 149 5 (2010): 775-784. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952609107&partnerID=MN8TOARS.
    10.1111/j.1365-2141.2010.08165.x
  66. Manco, Licínio. "Novel human pathological mutations. Gene symbol: PKLR. Disease: pyruvate kinase deficiency.". Human genetics (2009): http://europepmc.org/abstract/med/19309805.
  67. Manco, Licínio; Manco, L.; Trovoada, M.J.; Ribeiro, M.L.. "Novel human pathological mutations. Gene symbol: PKLR. Disease: pyruvate kinase deficiency.". Human genetics 125 3 (2009): http://europepmc.org/abstract/med/19320017.
  68. Manco, L.; Machado, P.; Lopes, D.; Nogueira, F.; Do Rosário, V.E.; Alonso, P.L.; Varandas, L.; et al. "Analysis of TPI gene promoter variation in three sub-Saharan Africa population samples". American Journal of Human Biology 21 1 (2009): 118-120. http://www.scopus.com/inward/record.url?eid=2-s2.0-59549103434&partnerID=MN8TOARS.
    10.1002/ajhb.20819
  69. Coutinho, R.; Bento, C.; Almeida, H.; Cunha, E.; Manco, L.; Ferreira, F.; Ribeiro, M.L.. "Complex inheritance of chronic haemolytic anaemia". British Journal of Haematology 144 4 (2009): 615-616. http://www.scopus.com/inward/record.url?eid=2-s2.0-58549113159&partnerID=MN8TOARS.
    10.1111/j.1365-2141.2008.07479.x
  70. Manco, Licínio. "Gene symbol: PKLR. Disease: Pyruvate kinase deficiency.". Human genetics (2008): http://europepmc.org/abstract/med/18846674.
  71. Manco, Licínio; Arede, Pedro; Silva, Isabel; Alvarez, Manuela; Abade, Augusto. "Estudo populacional de 6 STRs (TH01, TPOX, CSF1PO, D7S820, D13S317 e D16S539) na região Centro de Portugal". (2008): http://hdl.handle.net/10316/21519.
  72. Manco, Licínio. "Novel human pathological mutations. Gene symbol: TPI1. Disease: triosephosphate isomerase deficiency.". Human genetics (2007): http://europepmc.org/abstract/med/17879449.
  73. Manco, Licínio. "Novel human pathological mutations. Gene symbol: G6PD. Disease: glucose-6-phosphate dehydrogenase deficiency.". Human genetics (2007): http://europepmc.org/abstract/med/17879442.
  74. Manco, L.; Ribeiro, M.L.. "Novel human pathological mutations. Gene symbol: TPI1. Disease: triosephosphate isomerase deficiency.". Human genetics 121 5 (2007): http://www.scopus.com/inward/record.url?eid=2-s2.0-35148860196&partnerID=MN8TOARS.
  75. Manco, L.; Gonçalves, P.; Antunes, P.; Maduro, F.; Abade, A.; Ribeiro, M.L.. "Mutations and haplotype diversity in 70 Portuguese G6PD-deficient individuals: An overview on the origin and evolution of mutated alleles". Haematologica 92 12 (2007): 1713-1714. http://www.scopus.com/inward/record.url?eid=2-s2.0-37049031034&partnerID=MN8TOARS.
    10.3324/haematol.11670
  76. Manco, L.; Botigué, L.R.; Ribeiro, M.L.; Abade, A.; Manco, Licínio. "G6PD deficient alleles and haplotype analysis of human G6PD locus in São Tomé e Príncipe (West Africa)". Human Biology 79 6 (2007): 679-686. http://www.scopus.com/inward/record.url?eid=2-s2.0-42649135542&partnerID=MN8TOARS.
  77. Manco, Licínio. "Gene symbol: NT5C3. Disease: pyrimidine 5'-nucleotidase (P5'N) deficiency.". Human genetics (2006): http://europepmc.org/abstract/med/17128459.
  78. Manco, Licínio; Manco, L.; Relvas, L.; Pinto, C.S.; Pereira, J.; Almeida, A.B.; Ribeiro, M.L.. "Molecular characterization of five Portuguese patients with pyrimidine 5'-nucleotidase deficient hemolytic anemia showing three new P5'N-I mutations.". Haematologica 91 2 (2006): 266-267. http://europepmc.org/abstract/med/16461318.
  79. Manco, Licínio; Manco, L.; Pereira, J.; Bento, M.C.; Ribeiro, M.L.. "Gene symbol: NT5C3. Disease: haemolytic anemia.". Human genetics 118 3-4 (2005): http://europepmc.org/abstract/med/16402212.
    10.1007/s00439-005-0040-x
  80. Manco, Licínio. "Two new glucose-6-phosphate dehydrogenase mutations causing chronic hemolysis.". Haematologica (2005): http://europepmc.org/abstract/med/16079115.
  81. Manco, Licínio. "Consequences at mRNA level of the PKLR gene splicing mutations IVS10(+1)G-->C and IVS8(+2)T-->G causing pyruvate kinase deficiency.". British journal of haematology (2002): http://europepmc.org/abstract/med/12181074.
    10.1046/j.0007-1048.2002.03665.x
  82. Manco, Licínio. "Population genetics of four PKLR intragenic polymorphisms in Portugal and São Tomé e Príncipe (Gulf of Guinea).". Human biology (2001): http://europepmc.org/abstract/med/11459427.
  83. Manco, L.. "Pyruvate kinase deficiency: Prevalence of the 1456C ¿ T mutation in the Portuguese population [2]". Clinical Genetics 60 6 (2001): 472-473. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035697427&partnerID=MN8TOARS.
    10.1034/j.1399-0004.2001.600612.x
  84. Manco, L.; Ribeiro, M.L.; Maximo, V.; Almeida, H.; Costa, A.; Freitas, O.; Barbot, J.; Abade, A.; Tamagnini, G.. "A new PKLR gene mutation in the R-type promoter region affects the gene transcription causing pyruvate kinase deficiency". British Journal of Haematology 110 4 (2000): 993-997. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033765506&partnerID=MN8TOARS.
    10.1046/j.1365-2141.2000.02283.x
  85. Manco, L.; Ribeiro, M.L.; Almeida, H.; Freitas, O.; Abade, A.; Tamagnini, G.. "PK-LR gene mutations in pyruvate kinase deficient Portuguese patients". British Journal of Haematology 105 3 (1999): 591-595. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033066614&partnerID=MN8TOARS.
    10.1046/j.1365-2141.1999.01387.x
  86. Licínio Manco; António Amorim. "Human erythrocyte pyrimidine 5'-nucleotidase isozymes: Effect of sulfhydryl reagents and electrophoretic discrimination". Electrophoresis 14 1 (1993): 1084-1085. http://dx.doi.org/10.1002/elps.11501401174.
    10.1002/elps.11501401174
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022/11/26 Association analysis between common variants in PCSK1 gene and obesity risk in Portuguese children 26º CONGRESSO PORTUGUÊS DE OBESIDADE
SPEO (Portugal)
2022/10/12 Molecular heterogeneity of Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency in the Portuguese population DCV talks
Departamento de Ciências da Vida (Coimbra, Portugal)
2021/11/19 Next-generation sequencing of 12 monogenic obesity genes in a Portuguese cohort of individuals with severe obesity. 25º CONGRESSO PORTUGUÊS OBESIDADE
SPEO (Portugal)
2019/11/21 Association between the FTO gene and abdominal obesity in children 23º Congresso Português de Obesidade
SPEO
2019/10/25 MODELOS MULTILOCUS PARA EVALUAR ASOCIACIONES GENÉTICAS CON LA VARIACIÓN DE HbF EN PORTADORES DE BETA-TALASEMIA DE ORIGEN PORTUGUESA LXI Congreso Nacional de la Sociedad Española de Hematología y Hemoterapia SEEH
Sociedad Española de Hematología y Hemoterapia SEEH (Valencia, Spain)
2017/07/03 Genetic basis of pathological conditions: studies on haematologic and obesity phenotypes in the Portuguese population Encontro Ciência 2017
FCT (Lisboa, Portugal)
2016/06/02 Association study between three MC4R variants and obesity-related variables in Portuguese young adults XL Jornadas Portuguesas de Genética
Sociedade Portuguesa de Genética (Coimbra, Portugal)
2015/11/12 Anemia hemolítica hereditária por défice de GPI: duas novas mutações em dois doentes de naturalidade Portuguesa Reunião Anual da Sociedade Portuguesa de Hematologia
Sociedade Portuguesa de Hematologia (Figueira da Foz, Portugal)
2015/10/24 Anemia hemolítica hereditaria por déficit de GPI: dos nuevas mutaciones en un varón Portugués LVII Congreso Nacional de la SEHH y XXXI Congreso Nacional de la SETH
Sociedad Española de Hematología y Hemoterapia SEEH (Valencia, Spain)
2015/10/24 Anemia hemolítica hereditaria por déficit de GPI: dos nuevas mutaciones en un varón Portugués LVII Congreso Nacional de la SEHH y XXXI Congreso Nacional de la SETH
(Valencia, Spain)
2015 Estudo da associação de polimorfismos do gene 5-HTT com a obesidade 19º Congresso Português de Obesidade
SPEO (Lisboa, Portugal)
2013/11/21 Genetic variants underlying fetal hemoglobin levels in normal subjects with common hereditary persistence of fetal hemoglobin and in ß-thalassemia carriers 17ª Reunião da Sociedade Portuguesa de Genética Humana (SPGH)
SPGH (Coimbra, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/09/01 - Current GENETIC LEGACY OF THE Y CHROMOSOME IN THE DISTRICT OF SANTARÉM WITH A PARTICULAR FOCUS ON THE TOMAR POPULATION
Supervisor
 Mestrado em Evolução e Biologia Humanas (Master)
Universidade de Coimbra, Portugal
2023/09/01 - Current Estudo de variantes genéticas associadas ao aumento dos níveis de hemoglobina fetal em mulheres naturais de S. Tomé e Príncipe
Supervisor
 Mestrado em Evolução e Biologia Humana (Master)
Universidade de Coimbra, Portugal
2020 - 2021 MOLECULAR CHARACTERIZATION OF CONGENITAL ERYTHROCYTOSIS AND IDIOPATHIC ERYTHROCYTOSIS ANALYSED BY NEXT-GENERATION SEQUENCING
Supervisor
 Mestrado em Biologia Celular e Molecular (Master)
Universidade de Coimbra, Portugal
2016 - 2021 DNA methylation as an age predictor in living and deceased individuals
Supervisor of Maria Helena Correia Dias
 Antropologia (PhD)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018 - 2019 Estudo de variantes genéticas associadas ao aumento de HbF na população Portuguesa
Co-supervisor
 Evolução e Biologia Humanas (Master)
Universidade de Coimbra, Portugal
2018 - 2019 Genetic variations in the ß-globin cluster: influence on levels of fetal hemoglobin
Co-supervisor
 Mestrado em Genética Forense (Master)
Universidade do Porto, Portugal
2017 - 2018 Influence of physical activity on the association between FTO and SLC6A4 genetic variants and obesity among Portuguese children
Co-supervisor
 Evolução e Biologia Humanas (Master)
Universidade de Coimbra, Portugal
2015 - 2018 Where is the missing heritability of the genetic of common obesity susceptibility risk?
Supervisor of David Santos Albuquerque
 Post Doc (Other)
Universidade de Coimbra, Portugal
2016 - 2017 Single Nucleotide Polymorphisms associated with venous thromboembolism - Factor XI, ABO blood group and Fibrinogen loci - Evaluation in a Portuguese Population group
Co-supervisor
 Medicina
Universidade de Coimbra, Portugal
2014 - 2015 Estudo de variantes genéticas associadas a comportamentos agressivos numa amostra populacional portuguesa
Co-supervisor
 Evolução e Biologia Humanas (Master)
Universidade de Coimbra, Portugal
2011 - 2015 Estudo de variantes genéticas associadas à obesidade em crianças portuguesas
Supervisor
 Antropologia (PhD)
Universidade de Coimbra, Portugal
2013 - 2014 Legado Genético do Cromossoma Y: caracterização do haplogrupo J em amostras de origem portuguesa com foco na zona centro
Co-supervisor
 Evolução e Biologia Humanas (Master)
Universidade de Coimbra, Portugal
2012 - 2013 Análise haplotípica de mutações comuns no gene HFE associadas à Hemocromatose em Portugal
Co-supervisor
 Biologia (Master)
Universidade de Coimbra, Portugal
2012 - 2013 Estudo de polimorfismos associados ao aumento da expressão de Hemoglobina Fetal
Co-supervisor
 Biologia (Master)
Universidade de Coimbra, Portugal
2011 - 2012 Variação geográfica da diversidade haplotípica ligada a mutações no gene APOL1 que conferem resistência à doença do sono
Co-supervisor
 Evolução e Biologia Humanas (Master)
Universidade de Coimbra, Portugal
2011 - 2012 Pesquisa de assinaturas de selecção de malária na região do gene humano TPI
Co-supervisor
 Parasitologia Médica (Master)
Universidade Nova de Lisboa, Portugal
2009 - 2010 Variabilidade do cromossoma Y na população do distrito de Coimbra: tentativa de pesquisa da herança genética de eventos históricos
Co-supervisor
 Evolução e Biologia Humanas (Master)
Universidade de Coimbra, Portugal
2009 - 2010 Estudo da Variabilidade Genética Associada à Persistência de Lactase em Portugal e em diversas Populações Africanas
Co-supervisor
 Evolução e Biologia Humanas (Master)
Universidade de Coimbra, Portugal
2008 - 2009 Análise da diversidade no locus da Ferroportina (gene SLC40A1) em três amostras populacionais Africanas e numa amostra da região centro de Portugal
Co-supervisor
 Evolução e Biologia Humanas (Master)
Universidade de Coimbra, Portugal
2006 - 2007 Caracterização Genética da População Judaica de Trás-os-Montes e Belmonte com base no estudo de polimorfismos do cromossoma Y
Co-supervisor
 Evolução e Biologia Humanas (Master)
Universidade de Coimbra, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2021/07/21 DNA methylation as an age predictor in living and deceased individuals Metilação de DNA como um preditor de idade em indivíduos vivos e mortos
Supervisor
 Maria Helena Correia Dias (PhD)
Universidade de Coimbra, Portugal
2021/03/12 Red blood cell enzymopathies – effects on malaria infection: the importance of host cell membrane in host-parasite interactions re-vealed by atomic force microscopy and quantitative proteomics
Thesis Member
 Tiago António Casaca Vaz (PhD)
Universidade Nova de Lisboa, Portugal
2020/12/09 Assessing ancestry through genetics: an attempt using skeletonized human remains
(Thesis) Main arguer
 Ana Sofia Alves Botelho (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2020/11/16 Genetic variants associated with aggressive behaviour in humans: the serotonergic system
(Thesis) Main arguer
 Mariana de Leão Pinheiro Gonçalves Pimentel (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2020/09/29 Epidemiologia das hemoglobinopatias: variabilidade genética da hemoglobina e de enzimas eritrocitárias no Bengo, Angola
(Thesis) Main arguer
 Chissengo Lucama Tchonhi (PhD)
2019/05/03 CONTRIBUTO PARA O ESTUDO DE MARCADORES GENÉTICOS COM INTERESSE MÉDICO-LEGAL, FORENSE E POPULACIONAL EM IMIGRANTES ORIUNDOS DE PAÍSES AFRICANOS INTEGRADOS NA POPULAÇÃO DE LISBOA
(Thesis) Main arguer
 António Joaquim Amorim dos Santos (PhD)
Universidade de Évora, Portugal
2018/03/27 Association of social, cultural and environmental factors with participation in extracurricular sport and obesity indicators in 6-10-year-old children living in urban and non-urban settings
(Thesis) Arguer
 Daniela Rodrigues da Costa (PhD)
Universidade de Coimbra, Portugal
2015/04/21 Estudo de variantes genéticas associadas à obesidade em crianças portuguesas
Supervisor
 David Santos Albuquerque (PhD)
Universidade de Coimbra, Portugal
2015/01/19 Association of childooh obesity with asthma and rhinitis symptoms in 6-8 years old children living in Coimbra district, Portugal: the role of environmental, family and socioeconomic factors
(Thesis) Arguer
 Magdalena Elzbieta Muc (PhD)
Universidade de Coimbra, Portugal
2015/01/08 HUMAN BIOMONITORING: BIOMARKERS, INDIVIDUAL SUSCEPTIBILITY AND NUTRIGENETICS
(Thesis) Main arguer
 Carina Alexandra Fernandes Ladeira (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal
2013/07/08 Pyruvate kinase and glucose-6-phosphate dehydrogenase deficiencies and their association with malaria – population genetics and proteomic studies
(Thesis) Arguer
 Patrícia Isabel Pires Machado (PhD)
Universidade Nova de Lisboa, Portugal
Distinctions

Award

2019 MENÇÃO HONROSA
Instituto Nacional de Medicina Legal e Ciências Forenses, Portugal
2019 Menção honrosa
Instituto Nacional de Medicina Legal e Ciências Forenses, Portugal
2018 PRÉMIO DE MELHOR POSTER
Instituto Nacional de Medicina Legal e Ciências Forenses, Portugal
2015 PRÉMIO MELHOR POSTER JOVEM INVESTIGADOR
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2013 Prémio Investigação em Pediatria