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I am a Junior Researcher at i3S, University of Porto, where I lead an independent research team with 2 PhD students and 1 MSc student within the Host Targets of Infection group. I am also an Invited Assistant Professor of Microbiology at ICBAS, U.Porto. My research focuses on developing infection models and novel drugs against Mycobacterium infections. Currently, I am the Principal Investigator of two FCT projects: MycoPepTalking and IronCell2Cell. Additionally, I am an active member of global networks such as COST Actions ADVANCE-TB (21164) and EURESTOP (21145). In total, during my scientific career, I i) Participated in 16 funded projects working with national and international teams in the fields of microbiology, infection, and biophysics, being the Principal Investigator in 2 projects (totalling over 950k€). ii) Authored/co-authored 27 scientific articles in peer-reviewed international journals, with more than 500 citations and an h-index of 16 (Scopus). iii) Supervised 2 PhD students (ongoing), 6 master and 7 undergraduate students, and mentored several young researchers. iv) Presented oral and poster communications in national and international meetings. v) Acted as a Reviewer and Associate Editor in different scientific journals. vi) Acted as a jury of academic degrees, public hiring processes, and external advisory board for doctoral theses, and scientific evaluation committees. vii) Am certified at the FELASA C category (functions A+B+D) and by DGAV for research with animals. viii) Have experience and technical independence for work within biosafety level 2 and 3 facilities.
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Identification

Personal identification

Full name
Tânia Martins da Silva

Citation names

  • Silva, Tânia

Author identifiers

Ciência ID
001E-1B3C-C38D
ORCID iD
0000-0002-6087-1487
Researcher Id
AAB-2131-2019
Scopus Author Id
56711406400

Email addresses

  • tania.silva@i3s.up.pt (Professional)

Telephones

Telephone
  • 220408800 Ext.: 6112 (Professional)

Addresses

  • i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto. Rua Alfredo Allen, 208, 4200-135, Porto, Porto, Portugal (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Microbiology
  • Medical and Health Sciences - Health Sciences - Infectious Diseases
  • Exact Sciences - Chemical Sciences - Physical Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
English Intermediate (B1) Advanced (C1) Intermediate (B1) Intermediate (B1)
Portuguese Intermediate (B1) Advanced (C1) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
2016/03/17
Concluded
 Ciências Biomédicas (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Mechanisms of action and antimycobacterial activity of antimicrobial peptides " (THESIS/DISSERTATION)
 Approved with distinction
2013
Concluded
 Accreditation, as a person responsible for the Design and conception of procedures and projects with laboratory animals (Outros)
Direcção-Geral de Alimentação e Veterinária, Portugal
2011
Concluded
 Bioquímica (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Studies of the effects of antimicrobial peptides on model membranes and relevant pathogens" (THESIS/DISSERTATION)
 17
2009
Concluded
 Bioquímica (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Estudo da interacção de um péptido antimicrobiano da família da Lactoferrampina (marcado com FITC) com membranas modelo e diferentes agentes patogénicos" (THESIS/DISSERTATION)
 15
Affiliation

Science

Category
Host institution 		Employer
2021/06/16 - Current Contracted Researcher (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2020/01/01 - 2021/03/31 Contracted Researcher (Research) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2016/06/01 - 2019/12/31 Postdoc (Research) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2016/02/01 - 2016/05/01 Researcher (Research) Universidade do Porto Centro de Investigação em Química, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2020/02/10 - Current Invited Assistant Professor (University Teacher) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Projects

Contract

Designation Funders
2024/03 - Current COST Action 21145 - European Network for diagnosis and treatment of antibiotic-resistant bacterial infections (EURESTOP)
CA21145
Researcher
European Cooperation in Science and Technology, Belgium
 European Cooperation in Science and Technology
Ongoing
2023/03 - Current IronCell2Cell - The macrophage – hepatocyte iron communication during mycobacterial infection
2022.03635.PTDC
10.54499/2022.03635.PTDC
Principal investigator
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2022/10 - Current COST Action 21164 - Towards an improvement in diagnostics and treatment strategies for TB control (ADVANCE-TB)
CA21164
Researcher
European Cooperation in Science and Technology, Belgium
 European Cooperation in Science and Technology
Ongoing
2021/04 - Current MycoPepTalking - Refining Antimicrobial Peptides with cutting-edge strategies to tackle infections by Nontuberculous Mycobacteria
PTDC/BIA-MIC/3458/2020
10.54499/PTDC/BIA-MIC/3458/2020
Principal investigator
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2022/06 - 2024/12 The Bone SAAver: Identification of mechanisms and biomarkers of bone loss in patients with Cystic Fibrosis
003055G221
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Cystic Fibrosis Foundation
Ongoing
2022/01 - 2024/01 IronIC - Infection and iron homeostasis: a new perspective for an old question
EXPL/BIA-BQM/1170/2021
Co-Principal Investigator (Co-PI)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2022/03 - 2023/06 Inflammabone - Understanding how chronic infection disrupts the hematopoietic niche leading to osteopenia
KOG-202108-00929
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 European Hematology Association
Concluded
2020/07 - 2021/07 Ironing COVID-19 | Finding in the host iron status the signature to predict the severity of the disease
FCT-RESEARCH4COVID-19-Projeto n. 569
Researcher
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Centro Hospitalar Universitário de São João, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2020/01 - 2021/03 Two4Three - A small couple for the big three
PTDC/BTM-SAL/29786/2017
Researcher
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

REQUIMTE LAQV Porto, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2019/01/01 - 2019/12/31 Centro de Investigação em Química da Universidade do Porto (Chemistry Research Center of the University of Porto)
UID/QUI/00081/2019
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Centro de Investigação em Química, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2019/01/01 - 2019/12/31 Institute for Research and Innovation in Health Sciences
UID/BIM/04293/2019
LA/P/0070/2020
10.54499/LA/P/0070/2020
Instituto Nacional de Engenharia Biomédica, Portugal

Universidade do Porto, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2016/07/01 - 2019/12/31 Ao Encontro das Regras para a Permeação Passiva através da Barreira Hemato-Encefálica
PTDC/DTP-FTO/2784/2014
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade do Porto Faculdade de Ciências, Portugal

Universidade de Coimbra, Portugal

Universidade de Évora, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2016/06 - 2019/12 Iron hide and seek- does ferritin help the macrophage fight mycobacteria?
grant.Provided by PTCRIS: 140308
PTDC/IMI-MIC/1683/2014
Post-doc Fellow
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2016 - 2019 Structured program on bioengineered therapies for infectious diseases and tissue regeneration
Norte-01-0145-FEDER-000012
Researcher
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 European Regional Development Fund
Concluded
2012/12 - 2012/12 Integrated Infrastructure Initiative for Neutron and Muon Spectroscopy (NMI3): SANS Experiment LLB-11046
NMI3-II/FP7 nº 283883
Researcher
Laboratoire Léon Brillouin, France
 European Commission
Concluded
2011 - 2012 Scientific and Technological Cooperation project Portugal(FTC)/Slovakia: Interaction of biologically relevant macromolecules and peptides with phospholipid membranes
SK-PT-0015-10
Researcher
Universidade do Porto Faculdade de Ciências, Portugal

Univerzita Komenského v Bratislave Farmaceutická Fakulta, Slovakia
Fundação para a Ciência e a Tecnologia
Concluded
2011 - 2011 Portuguese/Spanish Integrated action: Antimicrobial activity of lactoferrin peptides against Leishmania in vitro
E-40/09
Master Student Fellow
Centro de Investigaciones Biológicas, Spain
 Fundação para a Ciência e a Tecnologia
Concluded
2010 - 2011 HASYLAB Proposal II-20090024 EC: SAXS and WAXS Project - Influence of antimicrobial peptides from the Lactoferrin/Lactoferrampin family on the phase behaviour of bacterial model membranes
ELISA/FP7 nº 226716
Researcher
Deutsches Elektronen-Synchrotron, Germany
 European Commission
Concluded
Outputs

Publications

Book chapter
  1. Magalhães, Ana; Cardoso, Isabel; Almeida, Maria de Rosário; Gomes, Maria Salomé; Silva, Tânia; Costa, Vítor. "A abordagem do bioquímico". In One Health - Uma Saúde, Um Contributo da Universidade, edited by Adriano A. Bordalo e Sá; Begoña Pérez-Cabezas; Luísa Azevedo; Sofia A. Costa Lima. Porto, Portugal: U. Porto Press, 2024.
    Published
Conference abstract
  1. Oliveira, Gabriel S.; Bento, Clara M.; Pombinho, A.; Reis, R.; van Calster, K.; De Vooght, L.; Maia, André F.; et al. "Fast-tracking drug discovery against Mycobacterium abscessus". Paper presented in 11th i3S Annual Meeting, Póvoa Varzim, 2024.
  2. Bento, Clara M.; Oliveira, Gabriel S.; Geerts, L.; Gomes, M. Salomé; Silva, Tânia. "Optimizing macrophage infection with mycobacteria in different stages for drug development". Paper presented in 11th i3S Annual Meeting, Póvoa Varzim, 2024.
  3. Oliveira, Gabriel S.; Sousa, Sérgio; Gomes, M. Salomé; Silva, Tânia. "LFcin Refinery: A machine learning approach to improve antimicrobial peptides' efficacy against nontuberculous mycobacteria". Paper presented in 11th International Meeting on Antimicrobial Peptides (IMAP), London, 2024.
  4. Fonseca, Óscar; Ramos, A. S.; Silva, A.; Silva, Tânia; Gomes, M. Salomé; Moreira, Ana Carolina. "Infection-induced iron-shift: new players in serum iron transport". Paper presented in 2nd FeSImmChemNet Young Investigator meeting, Berlin, 2024.
  5. Gomes, L. T. S.; Fonseca, Óscar; Pires, J. M.; Oliveira, Gabriel S.; Ramos, A. S.; Oliveira, I.; Silva, Tânia; et al. "Serum Ferritin Release During Mycobacterial Infection: a Role for Extracellular Vesicles?". Paper presented in IJUP 2024 Meeting of Young Researchers from the University of Porto, Porto, 2024.
  6. Bento, Clara M.; Geerts, L.; Oliveira, Gabriel S.; Gonçalves, R.; Van Calster, K. ; Cos, P.; Gomes, M. Salomé; Silva, Tânia. "Development of complex in vitro models of mycobacterial infection for drug screening". Paper presented in 10th Molecular and Cell Biology Symposium, Porto, 2024.
  7. Moreira, Ana Carolina; Silva, Tânia; Fonseca, Óscar; Ramos, A. S.; Gomes, L. T. S.; Gomes, M. Salomé. "MitoIronTracker | The Macrophage-Hepatocyte communication during infection". Paper presented in FeSImmChemNet Annual Meeting, Prague, 2024.
  8. Bento, Clara M.; Calster, K. V.; Piller, T.; Oliveira, Gabriel S.; Vooght, L. D.; Cappoen, D.; Cos, P.; Gomes, Maria Salomé; Silva, Tânia. "Mycobacterium abscessus double-reporter strains: new tools to fight mycobacterial infections". Paper presented in The 2nd International Electronic Conference on Microbiology, 2023.
    Published
  9. Bento, Clara M.; Van Calster, K. ; Piller, T.; Oliveira, Gabriel S.; Gonçalves, R.; De Vooght, L.; Cappoen, D.; et al. "New tools for drug susceptibility testing against non-tuberculous mycobacteria". Paper presented in 10th i3S Annual Meeting, Póvoa Varzim, 2023.
  10. Ramos, A. S.; Fonseca, Óscar; Couto, C. A.; Gomes, L. T. S.; Oliveira, I.; Ferreira-da-Silva, F.; Silva, A. M. N.; et al. "Host-mycobacteria interactions: Who will claim the iron throne?". Paper presented in IJUP 2023 Meeting of Young Researchers from the University of Porto, Porto, 2023.
  11. Girão, M.; Santos, M.; Pinto, N.; Fujikura, J.; Gomes, M. Salomé; Silva, Tânia; Azevedo, I. C.; et al. "Bioprospecting seaweed-associated Actinobacteria for biotechnological relevant metabolite discovery". Paper presented in 3º Encontro Doutoramento em Ciências Biomédicas do ICBAS, Porto, 2023.
  12. Fonseca, Óscar; Ramos, A. S.; Silva, A.; Ferreira-da-Silva, F.; Silva, Tânia; Gomes, M. Salomé; Moreira, Ana Carolina. "IronIC | The serum “iron-shift” during mycobacterial infection". Paper presented in European Iron Club (EIC) meeting 2023, Frankfurt, 2023.
  13. Ramos, A. S.; Silva, Tânia; Gomes, M. Salomé; Moreira, Ana Carolina. "Infeção por micobactérias altera o perfil das proteínas que ligam ferro em circulação". Paper presented in Microbiologia 2022, Congresso internacional de microbiologia em língua Portuguesa, 2022.
  14. Moreira, Ana Carolina; Silva, Tânia; Mesquita, G.; Gomes, A.C.; Bento, Clara M.; Neves, J. V.; Rodrigues, D. F.; et al. "Myeloid H-ferritin is released into circulation and impacts liver iron distribution during mycobacterial infection". Paper presented in European Iron Club, Oxford, 2022.
  15. Bento, Clara M.; Silva, Tânia; Aguiar, Luísa; Teixeira, Cátia; Gomes, Paula; Ferraz, Ricardo; Gomes, Maria Salomé. "Repurposing conventional antimycobacterial drugs using ionic liquids". Paper presented in ECMC 2021 7th Edition, 2021.
    10.3390/ecmc2021-11535
  16. Bento, Clara M.; Silva, Tânia; Aguiar, Luísa; Teixeira, Cátia; Gomes, Paula; Ricardo Ferraz; Gomes, Maria Salomé. "Ionic liquids on the rescuing of conventional antimycobacterial drugs". Paper presented in IV International Caparica Conference in Antibiotic Resistance (IC2AR 2021), Caparica, 2021.
    Published • 10.5584/jiomics.v11i1.200
  17. Oliveira, Gabriel; Silva, Tânia; Gomes, Maria; Gomes, Paula; Teixeira, Cátia. "Designing a new antimycobacterial peptide to tackle Mycobacterium avium". Paper presented in ECMC 2020 6th Edition, 2020.
    10.3390/ecmc2020-07479
  18. Moreira, Ana Carolina; Silva, Tânia; Mesquita, G.; Gomes, A. C.; Bento, Clara M.; Gomes, M. Salomé. "Role of ferritin in resistance to mycobacterial infection- studies in the mouse model". Paper presented in II Simpósio de Investigação em Tuberculose e Micobactérias Não Tuberculosas em Portugal, Lisbon, 2020.
  19. Silva, Tânia; David Andreu; Sérgio S. Funari; Uhríková, Daniela; Bastos, Margarida. "Influence of antimicrobial peptides on POPE/POPG lamellar phase periodicity". Paper presented in 9th European Biophysics Congress, Lisbon, 2013.
    Published • 10.1007/s00249-013-0917-x
Conference paper
  1. Uhríková, D.; Hubcík, L.; Teixeira, J.; Funari, S.S.; Silva, T.; Bastos, M.. "Effect of cecropin A-melittin antimicrobial peptide on bacterial model membrane: SANS and SAXD". Paper presented in 19th Conference of Czech and Slovak Physicists, Presov, 2017.
    Published
Conference poster
  1. Bento, Clara M.; Van Calster, K. ; Piller, T.; Oliveira, Gabriel S.; De Vooght, L.; Cappoen, D.; Cos, P.; Gomes, M. Salomé; Silva, Tânia. "Mycobacterium abscessus double-reporter strains: new tools for drug discovery". Paper presented in MicroSummit’24, 2024.
  2. Ribeiro, M.; Bento, Clara M.; Gomes, M. Salomé; Silva, Tânia. "Optimizing mycobacterial pre-clinical models for drug screening". Paper presented in Microbiology Day, 2024.
  3. Ribeiro, M.; Bento, Clara M.; Gomes, M. Salomé; Silva, Tânia. "Optimizing mycobacterial pre-clinical models for drug screening". Paper presented in III Congresso Ciências, Poster Competition, 2024.
  4. Oliveira, Gabriel S.; Bento, Clara M.; Pombinho, A.; Reis, R.; Van Calster, K. ; De Vooght, L.; Maia, André F.; et al. "Boosting M. abscessus drug discovery: engineering high throughput screening with a double reporter strain". Paper presented in ESCMID/ASM Conference on Drug Development to Meet the Challenge of Antimicrobial Resistance, 2024.
  5. Fonseca, Óscar; Ramos, Ana; Couto, Carolina A; Silva, André; Frederico Ferreira-da-Silva; Silva, Tânia; Gomes, Maria Salomé; Moreira, Ana C.. "Finding the IronICProt, an undisclosed infection-induced iron binding protein". Paper presented in 48th FEBS Congress - Mining biochemistry for human health and well-being - Milano, Italy, 2024.
    10.1002/2211-5463.13837
  6. Bento, Clara M.; Geerts, Lisa; Oliveira, Gabriel S.; Gomes, Maria Salomé; Silva, Tânia. "The response of macrophages to infection is dependent on mycobacterial growth phase". Paper presented in 48th FEBS Congress, 2024.
    https://doi.org/10.1002/2211-5463.13837
  7. Oliveira, Gabriel S.; Bento, Clara M.; Pombinho, António; Reis, Rita; Calster, K. V.; Vooght, L. D.; Maia, André; et al. "Enhancing drug discovery against Mycobacterium abscessus: high-throughput screenings to tackle antimicrobial resistance". Paper presented in One Health PhD Forum, 2024.
  8. Bento, Clara M.; Jorge Gabriel de Sousa Oliveira; Lisa Geerts; Gomes, Maria Salomé; Silva, Tânia. "M&Ms – The dependence of bacterial growth phase on Mycobacterium-Macrophage interaction". Paper presented in 44th Annual Congress of the European Society of Mycobacteriology, Old St. John Congress and Event Centre, Bruges, Belgium, 2024.
  9. Ramos, Ana; Fonseca, Óscar; Gomes, Maria Salomé; Silva, Tânia; Moreira, Ana C.. Corresponding author: Ramos, Ana. "Macrophages' metabolism impacts Hepatocyte viability – an in vitro study". Paper presented in 6th Meeting of Medicinal Biotechnology, 2024.
  10. Oliveira, Gabriel S.; Bento, Clara M.; Pombinho, António; Reis, Rita; Calster, K. V.; Vooght, L. D.; Maia, André; et al. "Mycobacterium abscessus double reporter strain as a readout of therapeutic efficacy – high-throughput screening development and validation". Paper presented in 6th Meeting on Medicinal Biotechnology, 2024.
  11. Oliveira, Gabriel S.; Bento, Clara M.; Pombinho, A.; Reis, R.; Van Calster, K. ; De Vooght, L.; Maia, André F.; et al. "Mycobacterium abscessus double reporter strain as a readout of therapeutic efficacy – high-throughput screening development and validation". Paper presented in SLAS (Society for Laboratory Automation and Screening) Europe Conference and Exhibition, 2024.
  12. Fonseca, Óscar; Ramos, Ana; Couto, Carolina A; Silva, André; Frederico Ferreira-da-Silva; Silva, Tânia; Gomes, Maria Salomé; Moreira, Ana C.. "Triggering the shift - serum iron proteins in the crosstalk between iron biology and immune response". Paper presented in European Iron Club Conference, Toulouse, 2024.
  13. Fonseca, Óscar; Ramos, Ana; Couto, Carolina A; Silva, André; Frederico Ferreira-da-Silva; Silva, Tânia; Gomes, Maria Salomé; Moreira, Ana C.. "Serum iron redistribution during mycobacterial infection - exploring the iron-shift". Paper presented in 10th edition of the Molecular and Cell Biology Symposium - "A decade building science", 2024.
  14. Gomes, L. T. S.; Fonseca, Óscar; Pires, J. M.; Oliveira, Gabriel S.; Ramos, A. S.; Oliveira, I.; Silva, Tânia; et al. "Ferritin Release During Mycobacterial Infection: a Role for Extracellular Vesicles". Paper presented in MicroBiotec'23, 2023.
  15. Bento, Clara M.; Calster, K. V.; Piller, T.; Oliveira, Gabriel S.; Vooght, L. D.; Cappoen, D.; Cos, P.; Gomes, Maria Salomé; Silva, Tânia. "New tools for drug susceptibility testing against non-tuberculous mycobacteria". Paper presented in Brilliant PhDs, brighter future: Shaping Science together, 2023.
  16. Fonseca, Óscar; Couto, C. A.; Ramos, A. S.; Silva, André M. N.; Frederico Ferreira-da-Silva; Silva, Tânia; Gomes, Maria Salomé; Moreira, Ana C.. "The shift in iron metabolism: a new anti-inflammatory strategy?". Paper presented in 1st Symposium on Iron Metabolism and Cancer, 2023.
  17. Girão, Mariana; Santos, Matilde; Pinto, Nuno; Fujikura, Juliana; Gomes, Maria Salomé; Silva, Tânia; Costa, Isabel; et al. Corresponding author: Girão, Mariana. "Macroalgae-associated Actinobacteria: a prolific symbiosis for biotechnologically relevant compound discovery". Paper presented in XVII MaNaPro and XIII ECMNP, Granada, Spain, 2023.
  18. Girão, Mariana; Santos, Matilde; Pinto, Nuno; Fujikura, Juliana; Gomes, Maria Salomé; Silva, Tânia; Costa, Isabel; et al. Corresponding author: Girão, Mariana. "Seaweed-associated Actinobacteria: a hotspot for biotechnology-relevant compounds discovery". Paper presented in XVII International Symposium on Marine Natural Products | XIII European Conference on Marine Natural Products, 2023.
  19. Bento, Clara M.; Calster, K. V.; Piller, T.; Oliveira, Gabriel S.; Vooght, L. D.; Cappoen, D.; Cos, P.; Gomes, Maria Salomé; Silva, Tânia. Corresponding author: Silva, Tânia. "Characterization of novel double-reporter strains of Mycobacterium abscessus for drug discovery: A study in mScarlet". Paper presented in 43rd Annual Meeting of the European Society of Mycobacteriology, 2023.
  20. Juliana Fujikura; Nuno Pinto; Daniel Milhm; Girão, Mariana; Maria Fátima Carvalho; Gomes, Maria Salomé; Silva, Tânia. "Exploring the potential of algae-associated Actinobacteria as a source of antimycobacterial compounds". Paper presented in IJUP - Encontro de Investigação Jovem da Universidade do Porto, 2023.
  21. Ramos, Ana Sofia; Fonseca, Óscar; Frederico Ferreira-da-Silva; Silva, André M. N.; Silva, Tânia; Gomes, Maria Salomé; Moreira, Ana C.. "The serum "iron-shift" during mycobacterial infection". Paper presented in XLVIII Annual Meeting of the Portuguese Society for Immunology, 2023.
  22. Ramos, A. S.; Fonseca, Óscar; Frederico Ferreira-da-Silva; Silva, André M. N.; Silva, Tânia; Gomes, Maria Salomé; Moreira, Ana C.. "The serum "iron-shift" during mycobacterial infection". Paper presented in VIII Jornadas da Bioquímica, 2023.
  23. Bento, Clara M.; Marta Silva; Anna Olsson; Gomes, Maria Salomé; Silva, Tânia. "Infection of lung organoids to study mycobacterial drug susceptibility". Paper presented in 9th Ed Molecular and Cell Biology Symposium, 2023.
  24. Fonseca, Óscar; Ramos, Ana Sofia; Silva, Tânia; Gomes, Maria Salomé; Moreira, Ana C.. "Circulating iron binding proteins' profile during mycobacterial infection". Paper presented in 9th Ed Molecular and Cell Biology Symposium, 2023.
  25. Bento, Clara M.; Silva, Tânia; Aguiar, Luísa; Teixeira, Catia; Gomes, Paula; Ferraz, Ricardo; Gomes, Maria Salomé. "New ionic liquids to treat mycobacterial infection". Paper presented in EMBO Workshop on Tuberculosis, 2022.
  26. Oliveira, Gabriel S.; Teixeira, Catia; Gomes, Maria Salomé; Silva, Tânia. "Transforming a crude peptide sequence into valuable antimycobacterial products". Paper presented in 17th Naples Workshop on Bioactive Peptides, 2022.
  27. Bento, Clara M.; Gomes, Maria Salomé; Silva, Tânia. "New infection models to test drugs against nontuberculous mycobacteria". Paper presented in MICROBIOTEC21 Congress of Microbiology and Biotechnology, 2021.
  28. Oliveira, Gabriel S.; Silva, Tânia; Gomes, Maria Salomé; Gomes, Paula; Teixeira, Catia. "Antimicrobial peptides as a novel way to tackle Mycobacterium avium". Paper presented in IJUP - Encontro de Investigação Jovem da Universidade do Porto, 2020.
  29. Moreira, Ana C.; Silva, Tânia; Gonçalo Mesquita; Ana C. Gomes; Bento, Clara M.; Agostinho Almeida; Gomes, Maria Salomé. "The Double face of H-ferritin in mycobacterial infections". Paper presented in MycoPORTO - MycoNET Meeting, 2019.
  30. Bento, Clara M.; Silva, Tânia; Moreira, Ana C.; Teixeira, Catia; Ferraz, Ricardo; Prudêncio, Cristina; Gomes, Paula; Gomes, Maria Salomé. "Effect of ionic liquids against Mycobacterium avium". Paper presented in MycoPORTO - MycoNET Meeting, 2019.
  31. Costa, Raquel P.; Silva, Tânia; Gomes, Maria Salomé; Gomes, Paula; Teixeira, Catia. "Antimicrobial peptides as potential antimycobacterial leads". Paper presented in MycoPORTO - MycoNET Meeting, 2019.
  32. Moreira, Ana C.; Silva, Tânia; Gonçalo Mesquita; Ana C. Gomes; Gomes, Maria Salomé. "Understanding the role played by H-ferritin during mycobacterial infection in vivo". Paper presented in Bilbo TB - MycoNET Meeting, 2018.
  33. Gomes, Ana C; Moreira, Ana C; Silva, Tânia; Neves, João V; Mesquita, Gonçalo; Almeida, Agostinho A; Fernandes, Rui; et al. "Reduction in erythrocyte life span as a key component of mycobacteria induced anemia". Paper presented in Bilbo TB - MycoNET Meeting, 2018.
    10.3390/ecsoc-22-05692
  34. Moreira, Ana C.; Silva, Tânia; Ana C. Gomes; Gonçalo Mesquita; João V. Neves; Rodrigues, Pedro N. S.; Gomes, Maria Salomé. "Understanding the role played by H-ferritin during mycobacterial infection in vivo". Paper presented in XLIV Annual Meeting of the Portuguese Society for Immunology, 2018.
  35. Gonçalo Mesquita; Silva, Tânia; Moreira, Ana C.; Ana C. Gomes; Rodrigues, Pedro N. S.; Gomes, Maria Salomé. "H-ferritin is necessary for macrophage protection against iron toxicity". Paper presented in 6th i3S Annual Meeting, 2017.
  36. Silva, Tânia; Moreira, Ana C.; Ana C. Gomes; Gonçalo Mesquita; João V. Neves; Rodrigues, Pedro N. S.; Gomes, Maria Salomé. "Conditional H-ferritin deficient mice are more resistant to mycobacterial infections". Paper presented in MycoZAR - MycoNet Meeting, 2017.
  37. Ana C. Gomes; Moreira, Ana C.; Silva, Tânia; João V. Neves; Gonçalo Mesquita; Barreira-Silva, Palmira; Correia-Neves, Margarida; Rodrigues, Pedro N. S.; Gomes, Maria Salomé. "Impact of Mycobacterial Infection in Bone Marrow Hematopoietic Niche and Architecture". Paper presented in XLIII Annual Meeting of the Portuguese Society for Immunology, 2017.
  38. Moreira, Ana C.; João V. Neves; Silva, Tânia; Patricia Oliveira; Gomes, Maria Salomé; Rodrigues, Pedro N. S.. "Iron metabolism deregulation upon infection: the role of hepcidin". Paper presented in 5th i3S Annual Meeting, 2016.
  39. Moreira, Ana C.; João V. Neves; Silva, Tânia; Miguel Ramos; Gomes, Maria Salomé; Rodrigues, Pedro N. S.. "Listeria monocytogenes infection impairs mouse iron metabolism by a hepcidin independent mechanism". Paper presented in XLII Annual Meeting of the Portuguese Society of Immunology, 2016.
  40. Silva, Tânia; David Andreu; Gomes, Paula; Sérgio S. Funari; Hubcík, L.; Daniela Uhríková; José Teixeira; Bastos, Margarida. "The effect of cecropin A-melittin antimicrobial peptides on POPE/POPG model membranes - a biophysical approach using SANS and SAXD". Paper presented in Antibiotic Alternatives for the New Millenium, 2014.
  41. Moreira, Ana C.; João V. Neves; Silva, Tânia; Miguel Ramos; Gomes, Maria Salomé; Rodrigues, Pedro N. S.. "Deregulation of iron metabolism during Listeria monocytogenes infection in mice is not dependent on hepcidin expression". Paper presented in ICAR2014 III International Conference on Antimicrobial Research, 2014.
  42. Silva, Tânia; Bárbara Magalhães; Silvia Maia; Gomes, Paula; Nazmi, K.; Jan Bolscher; Bastos, Margarida; Gomes, Maria Salomé. "Antimicrobial activity of lactoferricin peptides against Mycobacterium avium and their synergistic effect with ethambutol". Paper presented in XXXVIII Annual Meeting of the Portuguese Society for Immunology, 2012.
  43. Silva, Tânia; Bárbara Magalhães; Silvia Maia; Gomes, Paula; Nazmi, K.; Bolscher, J.G.M.; Bastos, Margarida; Gomes, Maria Salomé. "Antimicrobial activity of lactoferricin peptides against Mycobacterium avium and their synergistic effect with ethambutol". Paper presented in AMP2012 Antimicrobial Peptide Symposium, 2012.
  44. Silva, Tânia; Bárbara Magalhães; Silvia Maia; Gomes, Paula; Nazmi, K.; Bolscher, J.G.M.; Bastos, Margarida; Gomes, Maria Salomé. "Antimicrobial activity of lactoferricin peptides against Mycobacterium avium and their synergistic effect with ethambutol". Paper presented in 3rd i3S Annual Meeting, 2012.
  45. Silva, Tânia; Adão, Regina; Paula Toimil; Prieto, X.; Nazmi, K.; Bolscher, J.G.M.; Bastos, Margarida. "Calorimetric studies of the effect of Lactoferrin derived antimicrobial peptides on model membranes". Paper presented in MEDICTA (10th Mediterranean Conference on Calorimetry and Thermal Analysis), 2011.
  46. Silva, Tânia; Paula Toimil; Prieto, X.; Nazmi, K.; Bolscher, J.G.M.; Gomes, Maria Salomé; Bastos, Margarida. "Synergistic effect of lactoferricin (17-30) and ethambutol against Mycobacterium avium growing inside macrophages". Paper presented in 2nd IMMC (2nd Iberic Meeting on Medicinal Chemistry), 2011.
  47. Silva, Tânia; Daniela Uhríková; Sérgio S. Funari; David Andreu; Gomes, Maria Salomé; Bastos, Margarida. "Microbiological and Biophysical studies of cecropin A-melittin hybrid peptides". Paper presented in IJUP - Encontro de Investigação Jovem da Universidade do Porto, 2011.
Journal article
  1. Gabriel S. Oliveira; Clara M. Bento; António Pombinho; Rita Reis; Kevin Van Calster; Linda De Vooght; André F. Maia; et al. "Assay Development for High-Throughput Drug Screening Against Mycobacteria". Journal of Visualized Experiments (2024): http://dx.doi.org/10.3791/66860.
    10.3791/66860
  2. Clara M. Bento; Kevin van Calster; Tatiana Piller; Gabriel S. Oliveira; Linda de Vooght; Davie Cappoen; Paul Cos; et al. "Characterization of novel double-reporter strains of Mycobacterium abscessus for drug discovery: a study in mScarlet". Microbiology Spectrum (2024): https://doi.org/10.1128/spectrum.00362-24.
    10.1128/spectrum.00362-24
  3. Gomes, Ana Cordeiro; Sousa, Daniela Monteiro; Oliveira, Tiago Carvalho; Fonseca, Óscar; Pinto, Ricardo J.; Silvério, Diogo; Fernandes, Ana Isabel; et al. "Serum amyloid A proteins reduce bone mass during mycobacterial infections". Frontiers in Immunology 14 (2023): http://dx.doi.org/10.3389/fimmu.2023.1168607.
    10.3389/fimmu.2023.1168607
  4. Clara M. Bento; Ana Teresa Silva; Bruno Mansano; Luísa Aguiar; Cátia Teixeira; Maria Salomé Gomes; Paula Gomes; Tânia Silva; Ricardo Ferraz. "Improving the Antimycobacterial Drug Clofazimine through Formation of Organic Salts by Combination with Fluoroquinolones". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24021402.
    10.3390/ijms24021402
  5. Moreira, Ana C.; Silva, Tânia; Gonçalo Mesquita; Ana Cordeiro Gomes; Clara M. Bento; João V. Neves; Daniela F. Rodrigues; et al. "H-Ferritin Produced by Myeloid Cells Is Released to the Circulation and Plays a Major Role in Liver Iron Distribution during Infection". International Journal of Molecular Sciences (2021): *equal contributions. https://doi.org/10.3390/ijms23010269.
    10.3390/ijms23010269
  6. Clara M. Bento; Maria Salomé Gomes; Tânia Silva. "Evolution of Antibacterial Drug Screening Methods: Current Prospects for Mycobacteria". Microorganisms (2021): https://doi.org/10.3390/microorganisms9122562.
    10.3390/microorganisms9122562
  7. Ana C. Moreira; Maria Jose Teles; Tânia Silva; Clara M. Bento; Inês Simões Alves; Luisa Pereira; João Tiago Guimarães; et al. "Iron Related Biomarkers Predict Disease Severity in a Cohort of Portuguese Adult Patients during COVID-19 Acute Infection". Viruses (2021): https://doi.org/10.3390/v13122482.
    10.3390/v13122482
  8. Oliveira, Gabriel S.; Costa, Raquel P.; Gomes, Paula; Gomes, Maria Salomé; Silva, Tânia; Teixeira, Cátia. "Antimicrobial Peptides as Potential Anti-Tubercular Leads: A Concise Review". Pharmaceuticals 14 4 (2021): 323. http://dx.doi.org/10.3390/ph14040323.
    Open access • Published • 10.3390/ph14040323
  9. Gonçalo Mesquita; Silva, Tânia; Ana C. Gomes; Pedro F. Oliveira; Marco G. Alves; Rui Fernandes; Agostinho A. Almeida; Ana C. Moreira; Maria Salomé Gomes. "H-Ferritin is essential for macrophages' capacity to store or detoxify exogenously added iron". Scientific Reports 10 1 (2020): *equal contributions. https://doi.org/10.1038/s41598-020-59898-0.
    Open access • Published • 10.1038/s41598-020-59898-0
  10. Clara M. Bento; Maria Salomé Gomes; Tânia Silva. "Looking beyond Typical Treatments for Atypical Mycobacteria". Antibiotics 9 1 (2020): 18-18. https://doi.org/10.3390/antibiotics9010018.
    10.3390/antibiotics9010018
  11. Ana Teresa Silva; Clara M. Bento; Ana C. Pena; Luísa M. Figueiredo; Cristina Prudêncio; Luísa Aguiar; Tânia Silva; et al. "Cinnamic Acid Conjugates in the Rescuing and Repurposing of Classical Antimalarial Drugs". Molecules (2019): https://doi.org/10.3390/molecules25010066.
    10.3390/molecules25010066
  12. Gomes, Ana Cordeiro; Moreira, Ana C.; Silva, Tânia; Neves, João V.; Mesquita, Gonçalo; Almeida, Agostinho A.; Barreira-Silva, Palmira; et al. "IFN gamma-Dependent Reduction of Erythrocyte Life Span Leads to Anemia during Mycobacterial Infection". The Journal of Immunology 203 9 (2019): 2485-2496. http://dx.doi.org/10.4049/jimmunol.1900382.
    10.4049/jimmunol.1900382
  13. Silva, T.; Claro, B.; Silva, B.F.B.; Vale, N.; Gomes, P.; Gomes, M.S.; Funari, S.S.; et al. "Unravelling a Mechanism of Action for a Cecropin A-Melittin Hybrid Antimicrobial Peptide: The Induced Formation of Multilamellar Lipid Stacks". Langmuir 34 5 (2018): 2158-2170. http://www.scopus.com/inward/record.url?eid=2-s2.0-85041467200&partnerID=MN8TOARS.
    10.1021/acs.langmuir.7b03639
  14. Silva, Tânia. "Immuno-Stimulatory Peptides as a Potential Adjunct Therapy against Intra-Macrophagic Pathogens". Molecules (2017): http://www.mdpi.com/1420-3049/22/8/1297.
    10.3390/molecules22081297
  15. Moreira, A.C.; Neves, J.V.; Silva, T.; Oliveira, P.; Gomes, M.S.; Rodrigues, P.N.. "Hepcidin- (in)dependent mechanisms of iron metabolism regulation during infection by Listeria and Salmonella". Infection and Immunity 85 9 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85027514055&partnerID=MN8TOARS.
    10.1128/IAI.00353-17
  16. Moniz, T.; Leite, A.; Silva, T.; Gameiro, P.; Gomes, M.S.; de Castro, B.; Rangel, M.. "The influence of functional groups on the permeation and distribution of antimycobacterial rhodamine chelators". Journal of Inorganic Biochemistry 175 (2017): 138-147. http://www.scopus.com/inward/record.url?eid=2-s2.0-85025674616&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2017.07.017
  17. Neves, J.V.; Ramos, M.F.; Moreira, A.C.; Silva, T.; Gomes, M.S.; Rodrigues, P.N.S.. "Hamp1 but not Hamp2 regulates ferroportin in fish with two functionally distinct hepcidin types". Scientific Reports 7 1 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85032985967&partnerID=MN8TOARS.
    10.1038/s41598-017-14933-5
  18. Silva, T.; Moreira, A.C.; Nazmi, K.; Moniz, T.; Vale, N.; Rangel, M.; Gomes, P.; et al. "Lactoferricin peptides increase macrophages' capacity to kill Mycobacterium avium". mSphere 2 4 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85027999471&partnerID=MN8TOARS.
    10.1128/mSphere.00301-17
  19. Moniz, T.; Silva, D.; Silva, T.; Gomes, M.S.; Rangel, M.. "Antimycobacterial activity of rhodamine 3,4-HPO iron chelators against Mycobacterium avium: Analysis of the contribution of functional groups and of chelator's combination with ethambutol". MedChemComm 6 12 (2015): 2194-2203. http://www.scopus.com/inward/record.url?eid=2-s2.0-84948746933&partnerID=MN8TOARS.
    10.1039/c5md00456j
  20. Marques, F.; Vale-Costa, S.; Cruz, T.; Marques, J.M.; Silva, T.; Neves, J.V.; Cortes, S.; et al. "Studies in the mouse model identify strain variability as a major determinant of disease outcome in Leishmania infantum infection". Parasites and Vectors 8 1 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84950313576&partnerID=MN8TOARS.
    10.1186/s13071-015-1259-6
  21. Silva, T.; Magalhães, B.; Maia, S.; Gomes, P.; Nazmi, K.; Bolscher, J.G.M.; Rodrigues, P.N.; Bastos, M.; Gomes, M.S.. "Killing of mycobacterium avium by lactoferricin peptides: Improved activity of arginine- and d-Amino-Acid-containing molecules". Antimicrobial Agents and Chemotherapy 58 6 (2014): 3461-3467. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901249691&partnerID=MN8TOARS.
    10.1128/AAC.02728-13
  22. Silva-Gomes, S.; Bouton, C.; Silva, T.; Santambrogio, P.; Rodrigues, P.; Appelberg, R.; Gomes, M.S.. "Mycobacterium avium infection induces H-ferritin expression in mouse primary macrophages by activating Toll-like receptor 2". PLoS ONE 8 12 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84891960497&partnerID=MN8TOARS.
    10.1371/journal.pone.0082874
  23. Silva, T.; Adão, R.; Nazmi, K.; Bolscher, J.G.M.; Funari, S.S.; Uhríková, D.; Bastos, M.. "Erratum: Structural diversity and mode of action on lipid membranes of three lactoferrin candidacidal peptides (Biochimica et Biophysica Acta - Biomembranes (2013) 1828 (1329-1339))". Biochimica et Biophysica Acta - Biomembranes 1828 11 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84885376854&partnerID=MN8TOARS.
    10.1016/j.bbamem.2013.03.018
  24. Vale-Costa, S.; Costa-Gouveia, J.; Pérez, B.; Silva, T.; Teixeira, C.; Gomes, P.; Gomes, M.S.. "N-cinnamoylated aminoquinolines as promising antileishmanial agents". Antimicrobial Agents and Chemotherapy 57 10 (2013): 5112-5115. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884220322&partnerID=MN8TOARS.
    10.1128/AAC.00557-13
  25. Silva, T.; Adão, R.; Nazmi, K.; Bolscher, J.G.M.; Funari, S.S.; Uhríková, D.; Bastos, M.. "Structural diversity and mode of action on lipid membranes of three lactoferrin candidacidal peptides". Biochimica et Biophysica Acta - Biomembranes 1828 5 (2013): 1329-1339. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875193941&partnerID=MN8TOARS.
    10.1016/j.bbamem.2013.01.022
  26. Silva, T.; Abengózar, M.A.; Fernandez-Reyes, M.; Andreu, D.; Nazmi, K.; Bolscher, J.G.M.; Bastos, M.; Rivas, L.. "Enhanced leishmanicidal activity of cryptopeptide chimeras from the active N1 domain of bovine lactoferrin". Amino Acids 43 6 (2012): 2265-2277. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872683954&partnerID=MN8TOARS.
    10.1007/s00726-012-1304-0
  27. Teixeira, J.; Silva, T.; Benfeito, S.; Gaspar, A.; Garrido, J.; Borges, F.. "Exploring natural profits: Development of novel and potent galloyl-cinnamic hybrids lipophilic antioxidants". Free Radical Biology and Medicine (2012): https://publons.com/wos-op/publon/27190315/.
    10.1016/J.FREERADBIOMED.2012.08.213
  28. Bastos, M.; Silva, T.; Teixeira, V.; Nazmi, K.; Bolscher, J.G.M.; Funari, S.S.; Uhríková, D.. "Lactoferrin-derived antimicrobial peptide induces a micellar cubic phase in a model membrane system". Biophysical Journal 101 3 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-80052503897&partnerID=MN8TOARS.
    10.1016/j.bpj.2011.06.038
Thesis / Dissertation
  1. "Mechanisms of action and antimycobacterial activity of antimicrobial peptides". PhD, Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, 2016.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/10 Current treatments and new approaches for non-tuberculous mycobacterial infections
Università Degli Studi di Cagliari (Cagliari, Italy)
2024/09 Accelerating M. abscessus drug discovery with novel double-reporter strains MycoBDN – MycoNET Meeting
Germans Trias i Pujol Research Institute (IGTP) (Badalona, Spain)
2024/06 M&Ms | The dependence of bacterial growth phase on Mycobacterium-Macrophage interaction 44th Annual Meeting of the European Society of Mycobacteriology
European Society of Mycobacteriology (Bruges, Belgium)
2023/07 Antimycobacterial drug screening: where do we stand? XVIII International Summer School “Molecular Biology, Biotechnology and Biomedicine”
Mechnikov Odesa National University (Odesa, Ukraine)
2023/05 Development and characterization of mycobacterial biofilm models to study drug susceptibility IJUP 2023 - Encontro de Investigação Jovem da Universidade do Porto
Universidade do Porto, Portugal (Porto, Portugal)
2023/04 Antimicrobial peptides and Mycobacterium
School of Medicine, Altinbas Üniversitesi (Istanbul, Turkey)
2023/03/20 Antimycobacterial drug screening: where do we stand? INNOVA4TB monthly sessions
(Spain)
2023/03 Antimicrobial peptides and mycobacterial infections DÜAGEM - Natural Products R&D Centre - Seminars
School of Pharmacy, Altinbas Üniversitesi (Istanbul, Turkey)
2022/11/29 Pep talk to nontuberculous mycobacteria - tackling infections using antimicrobial peptides Online International Course: Advances in Mycobacteria Research and Application
Oswaldo Cruz Foundation and Federal University of Rio de Janeiro, Brazil (Brazil)
2022/09 Lung organoids for the development of drugs against mycobacterial infections REMODEL Summer School: Next-Generation Organoids and organ-on-chip
(Porto, Portugal)
2021/06 Ionic liquids on the rescuing of conventional antimycobacterial drugs IV International Caparica Conference in Antibiotic Resistance (IC2AR 2021)
(Caparica, Portugal)
2016/09/29 Lactoferricin peptides increase macrophage's capacity to kill Mycobacterium avium MycoNET Meeting MycoBCN
(Barcelona, Spain)
2016/06/01 Lactoferricin peptides increase macrophage’s capacity to kill Mycobacterium avium XLII Annual Meeting of the Portuguese Society of Immunology
(Porto, Portugal)
2014/11/05 Antimicrobial activity of lactoferricin peptides against Mycobacterium avium - improved activity of arginine- and D-amino acids-containing peptides and synergistic effect with ethambutol Antibiotic alternatives for the new millennium
(Londres, United Kingdom)
2011/07/13 Effect of antimicrobial peptides derived from Lactoferrin against Mycobacterium avium and on model membranes RICI4 (4th Iberian Meeting on Colloids and Interfaces)
(Porto, Portugal)
2011/06/12 Leishmanicidal activity of lactoferrin-derived peptides 2nd IMMC (2nd Iberic Meeting on Medicinal Chemistry)
(Porto, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2024/09 - Current Advancing preclinical research on Mycobacterium abscessus: Development of Biofilm and Animal models
Supervisor
 Bioquímica (Master)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/01 - Current LFcin refinery: transforming a crude peptide sequence into valuable antimycobacterial products
Supervisor
 Biotecnologia Molecular e Celular Aplicada às Ciências da Saúde (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021/01 - Current NTM: New Tools against nontuberculous Mycobacteria
Supervisor
 Biologia Molecular e Celular (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/09 - 2024/10 The macrophage-hepatocyte iron communication during mycobacterial infection
Co-supervisor
 Bioquímica (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Faculdade de Ciências, Portugal
2023/09 - 2024/01 Exploring the relationship between mycobacterial growth phase and macrophage infection
Supervisor
 Drug Development: Pharmacist (Master)
Universiteit Antwerpen, Belgium
2022/09 - 2023/07 Development and characterization of mycobacterial biofilm models to study drug susceptibility
Supervisor
 Bioquímica (Degree)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/02 - 2023/06 Exploring the potential of Algae's symbiotic microorganisms as a source for antimycobacterial compounds
Supervisor
 Ciências do Meio Aquático (Degree)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/02 - 2023/06 Impact of Chronic Infection in Bone loss in patients with Cystic Fibrosis
Co-supervisor
 Bioquímica (Degree)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/01 - 2023/06 Qual o impacto da infeção crónica na perda de massa óssea em pacientes com Fibrose Quística?
Co-supervisor
 Biologia Celular e Molecular (Degree)
Universidade Nova de Lisboa, Portugal
2022/09 - 2023/02 Marine Actinobacteria: an important source of antimycobacterial agents
Supervisor
 Medicina Veterinária (Degree)
Universidade Federal de Viçosa, Brazil
2022/02 - 2022/06 Actinobacteria might hold the answer: searching for new therapeutical agents in the microbial world
Supervisor
 Bioquímica (Degree)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Faculdade de Ciências, Portugal
2020/09 - 2021/11 New roles for serum iron proteins during infection
Co-supervisor
 Bioquímica (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Faculdade de Ciências, Portugal
2019/10 - 2020/12 Exploring novel approaches to tackle Mycobacterium avium
Supervisor
 Bioquímica (Master)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018/08 - 2019/09 Evaluation of the effects of selected ionic liquids against Mycobacterium avium
Supervisor
 Bioquímica (Master)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019/04 - 2019/06 Desenvolvimento de novas terapias contra infeções por micobactérias.
Supervisor
 Biotecnologia Medicinal (Degree)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023/11 - Current BioEngHub: “What can peptides do for you?” (2023/11)
Seminar (Member of the Scientific Committee)
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023/05 - 2023/05 Organizing Committee of the Third Meeting PhD in Biomedical Sciences (2023/05 - 2023/05)
Meeting (Member of the Organising Committee)
 Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019/12/20 - 2019/12/20 Organizing Committee of the Second Meeting PhD in Biomedical Sciences (2019/12/20 - 2019/12/20)
Meeting (Member of the Organising Committee)
 Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2024/11 - 2024/11 Participation in a EU-OPENSCREEN training school dedicated to chemical biology and early drug discovery.
Workshop
 EU-OPENSCREEN Autumn Training School
European Research Infrastructure Consortium, Belgium
2023/12 - 2023/12 Participation in a course to learn how to apply the Publicase Method, an objective and straightforward technique for writing scientific papers quickly and efficiently.
Workshop
 Scientific Writing: How to streamline the process of writing a scientific paper
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023/09 - 2023/10 Participation in a course dedicated to equip research leaders with the knowledge base to effectively build, manage and inspire a research group in the academic enterprise.
Workshop
 Building and Leading Research Teams
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2021/11 - 2021/11 Participation in a course focused on project management, design to equip participants with basic skills in managing research projects.
Workshop
 Research Project Management
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016/06/14 - 2016/06/17 Participation in an advanced course dedicated to high content screening and image analysis
Workshop
 2nd Course on High Content Screening and Image Analysis for BioSciences
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2012/06/18 - 2012/06/22 Participation in an advanced course dedicated to optical microscopy
Workshop
 4th Course on Optical Microscopy Imaging for Biosciences
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2012/05/14 - 2012/05/25 Participation in an Laboratory Animal Science course accredited by FELASA for category C, functions A+B+D Course in Laboratory Animal Science: Category C, FELASA accreditation number 020/08
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024/07 Improving cell-based in vitro models for the study of host-pathogen interactions in tuberculosis
(Thesis) Main arguer
 Matilde Moura Oliveira Aleluia (Master)
Universidade de Aveiro, Portugal
2024/06 Investigation of the impact factors deteriorating large-scale performance of prokaryotic cells
(Thesis) Main arguer
 Rita Filipa da Rocha Cardoso (Other)
Universidade do Porto Faculdade de Ciências, Portugal
2023/07 Application of quorum sensing inhibitory signalling molecules against food spoilage yeasts
(Thesis) Main arguer
 Mariana Moura Magalhães (Other)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/06/16 Introductory steps into testing for antibacterial effects of phage proteins
(Thesis) Main arguer
 Sofia de Morais Borges (Other)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019/07/11 Gut, soil & faeces: Exploring Undesired and Symbiont Fungi Growth Inhibition in Fungus-growing Termites
(Thesis) Main arguer
 Maria Inês Barros Matos (Other)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Ad Hoc journal article review

Journal title (ISSN) Publisher
2023 - Current Frontiers in Immunology Frontiers
2023 - Current Antimicrobial Agents and Chemotherapy American Society for Microbiology
2021 - Current Biomolecules (2218-273X) MDPI
2021 - Current Microorganisms (2076-2607) MDPI
2021 - Current International Journal of Moleculer Sciences (1422-0067) MDPI
2021 - Current Frontiers in Drug Discovery Frontiers
2020 - Current Pharmaceutics (1999-4923) MDPI
2020 - Current Antibiotics (2079-6382) MDPI
2019 - Current Molecules (1420-3049) MDPI

Association member

Society Organization name Role
2024 - Current ESGB - ESCMID Study Group for Biofilms
2024 - Current ESGICH - ESCMID Study Group for Infections in Compromised Hosts
2024 - Current ESGMYC - ESCMID Study Group for Mycobacterial Infections
2023 - Current European Society of Clinical Microbiology and Infectious Diseases (ESCMID)
2023 - Current American Society for Microbiology (ASM)
2022 - Current European Society of Mycobacteriology (ESM)
2019 - Current Portuguese Society for Microbiology
2016 - Current Portuguese Society for Immunology

Conference scientific committee

Conference name Conference host
2023/05 - 2023/05 IJUP 2023 - Encontro de Investigação Jovem da Universidade do Porto Universidade do Porto, Portugal
2023/05 - 2023/05 Third Meeting PhD in Biomedical Sciences ICBAS - Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto, Portugal
2022/10 - 2022/10 5th Phday: Building Paths: The Science Behind Us Instituto de Investigação e Inovação em Saúde da Universidade do Porto
2020/10 - 2020/10 3rd PhDay | Back to the Future Instituto de Investigação e Inovação em Saúde da Universidade do Porto

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2021/02 - Current Microbiology Medicina (Mestrado integrado) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/09 - Current Microbiology Ciências do Meio Aquático (Licenciatura) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/09 - Current General Microbiology Bioquímica (Licenciatura) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/09 - Current Infection Biology Bioquímica (Mestrado integrado) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/02 - Current General Microbiology Medicina Veterinária (Mestrado integrado) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2016 - 2016 EMBO Pratical Course: Biomolecular Interaction Analysis 2016: From Molecules to Cells Isothermal Titration Calorimetry Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Journal scientific committee

Journal title (ISSN) Publisher
2021/10 - Current Frontiers in Drug Discovery (2674-0338) Frontiers

Mentoring / Tutoring

Topic Student name
2024 - 2024 Short-Term Scientific Mission within COST Action 21164 (PhD student; Slovenia) Nina Gradišek
2024 - 2024 Extracurricular internship (Medical Doctor; Infectious Dept; Portugal) Estela Sousa
2024 - 2024 ERASMUS+ internship (Biology Degree; Italy) Elisa Mura
2023 - 2023 Short-Term Scientific Mission within COST Action 21164 (PhD student; Turkey) Gülsah Sevimli
2021/07 - 2021/07 Extracurricular Internship Program (Master Pharmaceutical Sciences; Portugal) Tiago Miguel Brochado Teixeira
2019 - 2019 ERASMUS+ internship (Degree Biotechnology; Scotland) Ugne Balasviute
2016/09 - 2017/10 Master thesis (Biomedical Sciences; Portugal) Gonçalo Augusto Taborda da Costa Laranja Mesquita
2012 - 2013 Curricular Internship (Degree in Biochemistry; Portugal) Filipe Castro Marques
2012/02 - 2012/09 Curricular Internship (Degree in Biochemistry; Portugal) Bárbara Gomes Magalhães

Other jury / evaluation

Activity description Institution / Organization
2024 - Current Research fellowship at i3S within the project “Deciphering the immune mechanisms of tuberculosis disease severity through host-pathogen interactions” PTDC/SAU-INF/1172/2021 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2024 - Current External Advisory Board of a PhD thesis in the MCBiology doctoral program at i3S Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023 - Current Research fellowship at i3S within the project "IronIC | Infection and iron homeostasis: a new perspective for an old question" EXPL/BIA-BQM/1170/2021, funded by FCT. Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023 - Current External Advisory Board of a PhD thesis in the MCBiology doctoral program at i3S Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2022 - Current Postdoctoral fellowship at i3S within the project "Bone SAAver: Identification of mechanisms and biomarkers of bone loss in patients with Cystic Fibrosis" (#003055G221), funded by the Cystic Fibrosis Foundation (USA). Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2022 - Current Research fellowship at i3S within the project "IronIC | Infection and iron homeostasis: a new perspective for an old question" EXPL/BIA-BQM/1170/2021, funded by FCT. Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2022 - Current Postdoctoral fellowship at i3S within the project "TB-TARGET- A multidisciplinary approach to understand host and pathogen interactions to develop new strategies to target tuberculosis (HR21-00415)", funded by La Caixa Foundation. Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Distinctions

Award

2024 ERASMUS+ Teaching mobility fellowship
Erasmus Plus, Belgium
2024 Conference Grant from ADVANCE-TB COST Action 21164
European Cooperation in Science and Technology, Belgium
2024 Virtual Mobility Grant from ADVANCE-TB COST Action 21164
European Cooperation in Science and Technology, Belgium
2024 Conference Grant from EURESTOP COST Action 21145
European Cooperation in Science and Technology, Belgium
2022 ERASMUS+ Teaching mobility fellowship
Erasmus Plus, Belgium
2012 PhD individual fellowship SFRH/BD/77564/2011
Fundação para a Ciência e a Tecnologia, Portugal