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Patricia Moreira completed her Bachelor degree in Biology in 2013 at Faculty of Sciences of the University of Porto and her Master degree in Forensic Medicine in 2015 at Institute of Biomedical Sciences Abel Salazar of the University of Porto. In addition, she concluded in 2021 the Laboratory Animal Science course with functions a, b, c and d at Life and Health Sciences Research Institute of the University of Minho. She is PhD student in Pharmaceutical Sciences at Faculty of Pharmacy of the University of Coimbra. She published 11 articles in journals and has 1 International Patent and other 2 European Patent applications. She participates and/or participated as PhD Student Fellow in 1 project and as Research Fellow in 2 projects. She has participated in some Science Outreach activities and tutored several students throughout her academic path. Her work area is Medical and Health Sciences with emphasis on Basic Medicine and Neurosciences.
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Identification

Personal identification

Full name
Patricia Moreira

Citation names

  • Moreira, Patricia

Author identifiers

Ciência ID
001F-06FD-384B
ORCID iD
0000-0003-2727-512X

Email addresses

  • pmoreira@cnc.uc.pt (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
English Intermediate (B1) Advanced (C1) Intermediate (B1) Intermediate (B1)
French Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2022
Ongoing
 Pharmaceutical Sciences (Doutoramento)
Major in Pharmacology and Pharmacotherapy
Universidade de Coimbra Faculdade de Farmácia, Portugal
2021
Concluded
 Laboratory Animal Science course with functions a, b, c and d (Outros)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2015
Concluded
 Forensic Medicine (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Estudo analítico das interações metabólicas entre piperazinas utilizadas como drogas de abuso" (THESIS/DISSERTATION)
 17 valores
2013
Concluded
 Biology (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
"Deteção de proteínas de transporte ABC e marcadores tumorais no fígado de peixe-zebra (Danio rerio) após uma exposição ao Benzo(a)pireno" (THESIS/DISSERTATION)
 14 valores
Affiliation

Others

Category
Host institution 		Employer
2018/10 - Current PhD student Universidade de Coimbra Faculdade de Farmácia, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2017/11 - 2018/10 Research fellow Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2016/06 - 2017/06 Research fellow REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
Universidade do Porto Faculdade de Farmácia, Portugal
2015/11 - 2016/05 Lab Trainee Leibniz-Institut für Arbeitsforschung an der TU Dortmund, Germany
2014/09 - 2015/10 Master student Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Universidade do Porto Faculdade de Farmácia, Portugal
2012/09 - 2013/06 Lab Trainee Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
Projects

Contract

Designation Funders
2018/10/01 - Current Inpactus – innovative products and technologies from eucalyptus
COMPETE2020 nº 21874
PhD Student Fellow
Universidade de Coimbra, Portugal
 Agência Nacional de Inovação SA
2017/11/10 - 2018/09/30 HealthyAging 2020
CENTRO-01-0145-FEDER-000012
Research Fellow
Universidade de Coimbra, Portugal
 EU Framework Programme for Research and Innovation Excellent Science
Ongoing
2016/06/16 - 2017/06/15 Applied Molecular Biosciences Unit
UID/Multi/04378/2013
Research Fellow
REQUIMTE, Portugal
 Fundação para a Ciência e a Tecnologia
Outputs

Publications

Conference poster
  1. Moreira, Patricia; Macedo, Jéssica; Figueirinha, Artur; Salgueiro, Lígia; Batista, Maria Teresa; Silva, Sónia; Branco, Pedro Costa; Cruz, Maria Teresa; Pereira, Cláudia Fragão. "Neuroprotective properties of extracts from Eucalyptus globulus biomass and its beneficial effects in an Alzheimer's disease mouse model". Paper presented in 16th International Conference on Alzheimer's & Parkinson's Diseases, Barcelona, Spain, 2022.
  2. Moreira, Patricia; Figueirinha, Artur; Salgueiro, Lígia; Batista, Maria Teresa; Silva, Sónia; Branco, Pedro Costa; Cruz, Maria Teresa; Pereira, Cláudia Fragão. "Effects of extracts from forestry biomass in Alzheimer's disease in vitro and in vivo models: interplay between bioeconomy and health benefits". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, Coimbra, Portugal, 2021.
  3. Moreira, Patricia; Gonçalves, Maria José; Cavaleiro, Carlos; Figueirinha, Artur; Salgueiro, Lígia; Batista, Maria Teresa; Branco, Pedro Costa; Cruz, Maria Teresa; Pereira, Cláudia Fragão. "Chemical composition and bioactivity of phenolic compounds extracted from Eucalyptus globulus biomass". Paper presented in IberPhenol - International Conference, Coimbra, Portugal, 2020.
  4. Moreira, Patricia; Gonçalves, Maria José; Cavaleiro, Carlos; Figueirinha, Artur; Salgueiro, Lígia; Batista, Maria Teresa; Branco, Pedro Costa; Cruz, Maria Teresa; Pereira, Cláudia Fragão. "Antifungal activity and cytotoxicity evaluation of phenolic compounds extracted from Eucalyptus globulus biomass". Paper presented in Iberian Congress of Phenolic Compounds, Ourense, Spain, 2019.
  5. Silva, Ana; Pereira, Marta; Brites, Gonçalo; Neves, Bruno; Moreira, Patricia; Resende, Rosa; Silva, Maria Manuel; et al. "Skin allergens and Alzheimer´s disease: preliminary studies on an (im)probable link". Paper presented in Cell Signalingin Aging and Neurodegenerative Diseases, Coimbra, Portugal, 2019.
  6. Moreira, Patricia; Gonçalves, Maria José; Cavaleiro, Carlos; Figueirinha, Artur; Salgueiro, Lígia; Batista, Maria Teresa; Branco, Pedro Costa; Cruz, Maria Teresa; Pereira, Cláudia Fragão. "Determination of safe bioactive doses of essential oil and phenolic compounds extracted from Eucalyptus globulus leaves". Paper presented in Natural Products in Drug Discovery and Human Health (NatProdDDH) – PSE Meeting, Lisbon, Portugal, 2019.
  7. Pereira, Marta; Silva, Ana; Neves, Bruno; Moreira, Patricia; Silva, Maria Manuel; Santos, Armanda Emanuela; Pereira, Cláudia Fragão; Cruz, Maria Teresa. "Molecules with an improbable therapeutic application for Alzheimer’s disease". Paper presented in Ageing: models, mechanisms and therapies, Coimbra, Portugal, 2019.
  8. Resende, Rosa; Moreira, Patricia; Ferreira-Marques, Marisa; Dinis, Teresa; Oliveira, Francisco; Sereno, José; Abrunhosa, Antero; et al. "New chimeric peptides selectively inhibit APPß cleavage decreasing Aß formation and accumulation in AD models". Paper presented in 14th International Conference on Alzheimer's & Parkinson's Diseases, Lisbon, Portugal, 2019.
  9. Bravo, Rita Roque; Moreira, Patricia; Carvalho, Félix; Bastos, Maria Lurdes; Carmo, Helna; Dias-da-Silva, Diana. "The synthetic psychostimulant 4-fluoromethamphetamine induces in vitro hepatotoxic effects, via CYP2E1 metabolism". Paper presented in EUROTOX2018, Brussels, Belgium, 2018.
  10. Gelaude, Emmely; Garrido, Ermelinda Manuela; Moreira, Patricia; Carmo, Helena; Almeida, Isabel Filipa; Garrido, Jorge. "Stability and phototoxicity of DEET, a common active ingredient in insect repellents". Paper presented in ANALÍTICA 2018 - 9th Meeting of the Analytical Chemistry Division, Porto, Portugal, 2018.
  11. Ferreira, Bárbara; Dias-da-Silva, Diana; Rebelo, Rita; Moreira, Patricia; Carvalho, Félix; Bastos, Maria Lurdes; Carmo, Helena. "Citotoxicity of 3-methylmethcathinone (3-MMC or metaphedrone) in primary rat hepatocytes". Paper presented in II Congresso da Associação Portuguesa de Ciências Forenses e as Jornadas Científicas do Departamento de Ciências do Instituto Universitário de Ciências da Saúde, Porto, Portugal, 2017.
  12. Bravo, Rita Roque; Moreira, Patricia; Martins, Maria João; Carvalho, Félix; Bastos, Maria Lurdes; Carmo, Helena; Dias-da-Silva, Diana. "In vitro hepatotoxicity of two new psychoactive benzofurans (5-APB and 6-APB) used as recreational drugs". Paper presented in II Congresso da Associação Portuguesa de Ciências Forenses e as Jornadas Científicas do Departamento de Ciências do Instituto Universitário de Ciências da Saúde, Porto, Portugal, 2017.
  13. Martins, Maria João; Moreira, Patricia; Bravo, Rita Roque; Carmo, Helena; Carvalho, Félix; Bastos, Maria Lurdes; Dinis-Oliveira, Ricardo Jorge; Dias-da-Silva, Diana. "Ethanol additively enhanced cardiotoxicity of cocaine in vitro through oxidative damage and energetic deregulation". Paper presented in II Congresso da Associação Portuguesa de Ciências Forenses e as Jornadas Científicas do Departamento de Ciências do Instituto Universitário de Ciências da Saúde, Porto, Portugal, 2017.
  14. Martins, Maria João; Moreira, Patricia; Bravo, Rita Roque; Carmo, Helena; Carvalho, Félix; Bastos, Maria Lurdes; Dinis-Oliveira, Ricardo Jorge; Dias-da-Silva, Diana. "Oxidative damage and energetic crisis in cardiomyocytes after co-exposure of cocaine and morphine". Paper presented in EUROTOX2017, Bratislava, Slovakia, 2017.
  15. Moreira, Patricia; Cunha, Sara; Dias-da-Silva, Diana; Carvalho, Félix; Basto, Maria Lurdes; Carmo, Helena. "Development and validation of a method for the simultaneous determination of two piperazines used as drugs of abuse". Paper presented in EUROTOX2016, Seville, Spain, 2016.
  16. Dias-da-Silva, Diana; Moreira, Patricia; Silva, Maria João; Carvalho, Félix; Bastos, Maria Lurdes; Carmo, Helena. "In vitro hepatotoxicity of mixtures of benzylpiperazine (BZP) and 3-trifluoromethylphenylpiperazine (TFMPP)". Paper presented in SOT Annual Meeting - Society of Toxicology, New Orleans, USA, 2016.
  17. Moreira, Patricia; Cunha, Sara; Dias-da-Silva, Diana; Carmo, Helena. "Development and validation of a method for the simultaneous determination of two piperazines used as drugs of abuse". Paper presented in 8º IJUP - Encontro de Investigação Jovem da Universidade do Porto, Porto, Portugal, 2015.
  18. Machado, Sandrine Pontes; Cunha, Virginia; Moreira, Patricia; Reis-Henriques, Maria Armanda; Ferreira, Marta. "Detection of ABC transporter and tumour marker proteins in zebrafish (Danio rerio) liver after single exposures to diethylnitrosamine or benzo(a)pyrene". Paper presented in PRIMO17 - Pollutant Responses in Marine Organisms, Faro, Portugal, 2013.
  19. Moreira, Patricia; Machado, Sandrine Pontes; Machado, Virginia; Reis-Henriques, Maria Armanda; Ferreira, Marta. "Detection of ABC transporter and tumour markers proteins in zebrafish (Danio rerio) liver after a single exposure to benzo(a)pyrene". Paper presented in 6º IJUP - Encontro de Investigação Jovem da Universidade do Porto, Porto, Portugal, 2013.
Journal article
  1. Cátia. S. D. Oliveira; Patrícia Moreira; Maria T. Cruz; Cláudia M. F. Pereira; Artur M. S. Silva; Sónia A. O. Santos; Armando J. D. Silvestre. "Exploiting the Integrated Valorization of Eucalyptus globulus Leaves: Chemical Composition and Biological Potential of the Lipophilic Fraction before and after Hydrodistillation". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24076226.
    10.3390/ijms24076226
  2. Cátia S. D. Oliveira; Patrícia Moreira; Maria T. Cruz; Cláudia M. F. Pereira; Alexandre Gaspar; Carlos Pascoal Neto; Paula C. R. O. Pinto; et al. "An integrated green process for the extraction of triterpenic acids from Eucalyptus globulus leaves after hydrodistillation". RSC Sustainability (2023): https://doi.org/10.1039/D3SU00076A.
    10.1039/D3SU00076A
  3. Moreira, Patrícia; Matos, Patrícia; Figueirinha, Artur; Salgueiro, Lígia; Batista, Maria Teresa; Branco, Pedro Costa; Cruz, Maria Teresa; Pereira, Cláudia Fragão. "Forest Biomass as a Promising Source of Bioactive Essential Oil and Phenolic Compounds for Alzheimer's Disease Therapy". International Journal of Molecular Sciences 23 15 (2022): 8812. http://dx.doi.org/10.3390/ijms23158812.
    10.3390/ijms23158812
  4. Almeida, Tânia; Moreira, Patrícia; Sousa, Fábio J.; Pereira, Cláudia; Silvestre, Armando J. D.; Vilela, Carla; Freire, Carmen S. R.. "Bioactive Bacterial Nanocellulose Membranes Enriched with Eucalyptus globulus Labill. Leaves Aqueous Extract for Anti-Aging Skin Care Applications". Materials 15 5 (2022): 1982. http://dx.doi.org/10.3390/ma15051982.
    10.3390/ma15051982
  5. Moreira, Patrícia; Sousa, Fábio Jesus; Matos, Patrícia; Brites, Gonçalo Sousa; Gonçalves, Maria José; Cavaleiro, Carlos; Figueirinha, Artur; et al. "Chemical Composition and Effect against Skin Alterations of Bioactive Extracts Obtained by the Hydrodistillation of Eucalyptus globulus Leaves". Pharmaceutics 14 3 (2022): 561. http://dx.doi.org/10.3390/pharmaceutics14030561.
    10.3390/pharmaceutics14030561
  6. Rocha, Maria Inês; Gonçalves, Maria José; Cavaleiro, Carlos; Cruz, Maria Teresa; Pereira, Cláudia; Moreira, Patrícia; Salgueiro, Lígia; Figueirinha, Artur. "Chemical characterization and bioactive potential of Artemisia campestris L. subsp. maritima (DC) Arcang. essential oil and hydrodistillation residual water". Journal of Ethnopharmacology (2021): 114146. http://dx.doi.org/10.1016/j.jep.2021.114146.
    10.1016/j.jep.2021.114146
  7. Patrícia, Moreira; Diana Dias da, Silva; Sara, Cunha; Maria de Lourdes, Bastos; Helena, Carmo. "Development and Validation of a GC-MS Method for the Simultaneous Quantification of Two Piperazine Designer Drugs Sold in Combination as 'Legal X'". Annals of Toxicology 2 1 (2020): http://dx.doi.org/10.36959/736/635.
    10.36959/736/635
  8. Ana Silva; Marta Pereira; Mylène A. Carrascal; Gonçalo Brites; Bruno Neves; Patrícia Moreira; Rosa Resende; et al. "Calcium Modulation, Anti-Oxidant and Anti-Inflammatory Effect of Skin Allergens Targeting the Nrf2 Signaling Pathway in Alzheimer’s Disease Cellular Models". International Journal of Molecular Sciences 21 20 (2020): 7791-7791. https://doi.org/10.3390/ijms21207791.
    10.3390/ijms21207791
  9. Resende, Rosa; Ferreira-Marques, Marisa; Moreira, Patrícia; Coimbra, Judite R.M.; Baptista, Salete J.; Isidoro, Ciro; Salvador, Jorge A.R.; et al. "New BACE1 Chimeric Peptide Inhibitors Selectively Prevent AßPPß Cleavage Decreasing Amyloid-ß Production and Accumulation in Alzheimer’s Disease Models". Journal of Alzheimer's Disease (2020): 1-21. http://dx.doi.org/10.3233/jad-200381.
    10.3233/jad-200381
  10. Oliveira, Cátia S. D.; Moreira, Patrícia; Resende, Judite; Cruz, Maria T.; Pereira, Cláudia M. F.; Silva, Artur M. S.; Santos, Sónia A. O.; Silvestre, Armando J. D.. "Characterization and Cytotoxicity Assessment of the Lipophilic Fractions of Different Morphological Parts of Acacia dealbata". International Journal of Molecular Sciences 21 5 (2020): 1814. http://dx.doi.org/10.3390/ijms21051814.
    10.3390/ijms21051814
  11. Maciel, B.; Moreira, P.; Carmo, H.; Gonçalo, M.; Lobo, J.M. Sousa; Almeida, I.F.. "Implementation of an in vitro methodology for phototoxicity evaluation in a human keratinocyte cell line". Toxicology in Vitro 61 (2019): 104618. http://dx.doi.org/10.1016/j.tiv.2019.104618.
    10.1016/j.tiv.2019.104618
  12. Dias da Silva, Diana; Silva, Maria João; Moreira, Patrícia; Martins, Maria João; Valente, Maria João; Carvalho, Félix; Bastos, Maria de Lourdes; Carmo, Helena. "In vitro hepatotoxicity of ‘Legal X’: the combination of 1-benzylpiperazine (BZP) and 1-(m-trifluoromethylphenyl)piperazine (TFMPP) triggers oxidative stress, mitochondrial impairment and apoptosis". Archives of Toxicology 91 3 (2016): 1413-1430. http://dx.doi.org/10.1007/s00204-016-1777-9.
    10.1007/s00204-016-1777-9
  13. Dias-da-Silva, Diana; Moreira, Patricia; Silva, Maria João; Carmo, Helena. "In Vitro Hepatotoxicity of Mixtures of Benzylpiperazine (BZP) and 3-Trifluoromethylphenylpiperazine (TFMPP)". The Toxicologist. Supplement to Toxicological Sciences 150 1 (2016): 104.
Thesis / Dissertation
  1. Moreira, Patricia. "Estudo analítico das interações metabólicas entre piperazinas utilizadas como drogas de abuso". Master, Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, 2015.

Intellectual property

Provisional application for patent
  1. 2022. "Integrated process for extracting bioactive compounds from eucalyptus biomass - European Patent EP22020513.2".
    Disclosed
  2. 2022. "Essential oil or extract products with phenolic compounds obtained from the wastewater from the hydrodistillation of Eucalyptus globulus leaves, their uses, formulations, bacterial cellulose membranes and face masks that incorporate them - European Patent EP22020512.4".
  3. 2022. "Small molecules for use in preventing and/or treatment of neurodegenerative diseases - International Patent PCT/IB2022/052060".
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022 Protective effects of extracts from Eucalyptus globulus biomass in Alzheimer’s disease in vitro and in vivo models Iberoamerican Congress on Pulp and Paper Research (CIADICYP)
(Girona, Spain)
2021 Beneficial effects of compounds extracted from Eucalyptus globulus biomass on skin health XXV Conferência Internacional da Floresta, Pasta e Papel - TECNICELPA e XI CIADICYP
(Coimbra, Portugal)
2019 Electrophilic molecules with anti-inflammatory and neuroprotective properties L Anual Reunion of SPF
(Coimbra, Portugal)
2018 New chimeric peptides selectively inhibit APP-ß cleavage 32º Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência
(Lisboa, Portugal)
2017 Evaluation of the changes induced by piperazine designer drugs in the intracellular lipid profile 10º IJUP - Encontro de Investigação Jovem da Universidade do Porto
(Porto, Portugal)
2017 Hepatotoxicity of piperazine designer drugs: alterations in cholesterol biosynthesis and intracellular levels XLVII Anual Reunion of SPF
(Porto, Portugal)
2017 The new psychoactive drug 3-methylmethcathinone (3-MMC) induces hepatotoxicity toward primary rat hepatocytes by triggering intrinsic and extrinsic apoptosis pathways XLVII Anual Reunion of SPF
(Coimbra, Portugal)
2017 Toxicity of the new psychoactive substances butylone, buphedrone, 3,4-dimethylmethcathinone (3,4-DMMC), 4-fluoromethcathinone (4-FMC), 6-(2-aminopropyl)benzofuran (6-APB), and 5-(2-aminopropyl)benzofuran (5-APB) on in vitro hepatocyte models XLVII Anual Reunion of SPF
(Coimbra, Portugal)
2017 In vitro toxicity of cocaine when combined with frequently co-consumed substances XLVII Anual Reunion of SPF
(Coimbra, Portugal)
2017 3-Methylmethcathinone (3-MMC) elicits oxidative stress and apoptosis in primary rat hepatocytes 10º IJUP - Encontro de Investigação Jovem da Universidade do Porto
(Porto, Portugal)
2017 Toxicity of new psychoactive substances: effects of synthetic cathinones and benzofurans on in vitro hepatocyte models 10º IJUP - Encontro de Investigação Jovem da Universidade do Porto
(Porto, Portugal)
2017 Hepatotoxicity and cardiotoxicity of cocaine when combined with frequently co-consumed substances 10º IJUP - Encontro de Investigação Jovem da Universidade do Porto
(Porto, Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2019/09/18 - 2019/09/20 8th edition of the European Calcium Society (ECS) workshop, “Calcium Signaling in Aging and Neurodegenerative Disorders 2019” (2019/09/18 - 2019/09/20)
Workshop (Other)
 Universidade de Coimbra, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2019/12/17 - 2019/12/18 Presentation of a mini poster "Bioactivity of natural compounds extracted from the Portuguese forestry"
Meeting
 CIBB Meeting 2019
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/10/04 - 2019/10/04 Science Discussion
Workshop
 How to Write a Great Research Paper, and Get it Accepted by a Good Journal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/06/19 - 2019/06/19 Science Discussion
Workshop
 Nanotechnology and Brain Drug Delivery Workshop
Universidade de Coimbra Faculdade de Farmácia, Portugal
2018/09/28 - 2018/09/28 Science Communication
Exhibition
 Noite Europeia dos Investigadores 2018
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018/03/01 - 2018/03/31 Science Communication
Exhibition
 Semana Internacional do Cérebro 2018
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2011 - 2012 Course Participation
Other
 XII Curso de Introdução à MedicinaLegal e Outras Ciências Forenses
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Mentoring / Tutoring

Topic Student name
2020 - 2020 Project of Bachelor Degree in Biochemistry Rodolfo Simões
2019 - 2019 Erasmus Internship Thu Thao Truongová
2018 - 2018 Internship of Association of Pharmacy Students Daniela Marques Mateus
2018 - 2018 Internship of Association of Pharmacy Students Ana Sofia Lourenço Martins
2018 - 2018 Ciência Viva Summer Internship Tatiana Teixeira
2018 - 2018 Project of PhD in Chemistry Andreia Cunha
2017 - 2017 Master Thesis in Clinical and Forensic Analytical Toxicology Brandon Lage Aguiar
2017 - 2017 Master Thesis in Chemistry Emmely Gelaude