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Joana Real. Concluiu o(a) Doutoramento em Bioquímica em 2013/07/23 pelo(a) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Doutoramento em Doutoramento em Bioquímica, especialidade Biofísica Celular em 2013 pelo(a) Universidade de Coimbra Faculdade de Ciencias e Tecnologia e Licenciatura em Licenciatura em Bioquímica em 2006 pelo(a) Universidade de Évora. Publicou 14 artigos em revistas especializadas. Recebeu 1 prémio(s) e/ou homenagens. Atua na(s) área(s) de Ciências Naturais com ênfase em Ciências Biológicas com ênfase em Bioquímica e Ciências Naturais com ênfase em Ciências Biológicas com ênfase em Biofísica.
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Identification

Personal identification

Full name
Joana Real

Citation names

  • Real, Joana
  • Joana I. Real

Author identifiers

Ciência ID
0216-337A-F9F3
ORCID iD
0000-0003-0209-2378

Knowledge fields

  • Natural sciences - Biological Sciences - Biochemistry
  • Natural sciences - Biological Sciences - Biophysics

Languages

Language Speaking Reading Writing Listening Peer-review
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Beginner (A1) Intermediate (B1)
Portuguese Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Swedish Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2013/07/23
Concluded
 Bioquímica (Doutoramento)
Major in Especialidade: Biofísica Celular
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Regulação da atividade elétrica da célula ß-pancreática por canais de K+ sensíveis a Ca2+" (THESIS/DISSERTATION)
2006
Concluded
 Licenciatura em Bioquímica (Licenciatura)
Universidade de Évora, Portugal
"Contributo dos fungos do solo para a sua atividade enzimática" (THESIS/DISSERTATION)
 15
Affiliation

Science

Category
Host institution 		Employer
2015/11 - 2020/04 Research Assistant (Research) Göteborgs universitet Sahlgrenska Akademin, Sweden
2013 - 2015 Postdoc (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Others

Category
Host institution 		Employer
2016/12/01 - 2016/12/15 Course Laboratory Animal Science – Rodents and Lagomorphs Göteborgs Universitet, Sweden
2016/08/31 - 2016/12/06 Course Teaching and learning in Higher Education (HPE101) Göteborgs Universitet, Sweden
2016/06/01 - 2016/06/15 Course Supervision in Postgraduate Programs (HPE201) Göteborgs Universitet, Sweden
2011/04/01 - 2011/06/01 Course for achievement of “Certificate of pedagogical skills” (Certificado de competencias pedagógicas - CAP), Coimbra, Portugal Instituto do Emprego e Formação Profissional, Portugal
2010/04/19 - 2010/04/30 Laboratory Animal Science (FELASA - Category C) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2009/10/30 - 2009/11/01 8th Short Course Biological Systems Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2009/03/09 - 2009/03/13 Advance Course on Obesity and Type II Diabetes, of the Doctoral Programme in Experimental Biology and Biomedicine. Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2009/03/03 - 2009/03/06 Advance Course on Biomedical Imaging and Metabolism, of the Doctoral Programme in Experimental Biology and Biomedicine. Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2009/02/02 - 2009/02/13 Advance Course on Principles and Practice in Drug Development, of the Doctoral Programme in Experimental Biology and Biomedicine. Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2009/01/26 - 2009/01/30 Advance Course on Cell Death, of the Doctoral Programme in Experimental Biology and Biomedicine. Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2008/11/24 - 2008/11/28 Advance Course on Biology of Proteolysis, of the Doctoral Programme in Experimental Biology and Biomedicine. Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2008/09/30 - 2008/10/03 Advance Course on Biostatistics, of the Doctoral Programme in Experimental Biology and Biomedicine. Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2008/04/09 - 2008/04/11 International Courses on Toxicology: Metabolic Toxicology; From Pathway to Organism (CNC) (2008 edition). Universidade de Coimbra, Portugal
2007/10/19 - 2007/10/21 7th Short Course: Biospectroscopy and Imaging. Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Projects

Grant

Designation Funders
2014/07 - 2015/06 QREN project
sem referencia
Post-doc Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluded
2012/04 - 2014/09 Role of accumbens and amygdala in the control of chronic stress neuropathology
Provided by PTCRIS: 122254
122254
 Fundação para a Ciência e a Tecnologia, I.P.
2013/11 - 2014/06 DARPA project
09-68-ESR-FP-010
Post-doc Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluded
2008/02 - 2012/01 Regulação metabólica de canais de Ca2+ sensíveis à voltagem, priming e secreção de insulina em ratos normais e diabéticos
SFRH/BD/41725/2007
PhD Student Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluded

Contract

Designation Funders
2012/08 - 2013/10 PTDC/SAU-TOX/122005/2010 and PTDC/SAU-NSC/122254/2010
PTDC/SAU-TOX/122005/2010
PTDC/SAU-NSC/122254/2010
Integration into Research Grant Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluded
2005/09/01 - 2008/01 Synthesis of [60]fullerene derivatives with potential pharmacological activity
info:eu-repo/grantAgreement/FCT/POCI/58515/PT
Scientific Initiation Fellow
Universidade de Aveiro, Portugal
 Universidade do Algarve Faculdade de Ciências e Tecnologia
Concluded
Outputs

Publications

Journal article
  1. Leffa DT; Pandolfo P; Gonçalves N; Machado NJ; de Souza CM; Real JI; Silva AC; et al. "Adenosine A2A Receptors in the Rat Prelimbic Medial Prefrontal Cortex Control Delay-Based Cost-Benefit Decision Making.". Frontiers in molecular neuroscience (2018): http://europepmc.org/abstract/med/30618621.
    10.3389/fnmol.2018.00475
  2. Amber Kerkhofs; Paula M. Canas; A. J. Timmerman; Tim S. Heistek; Joana I. Real; Carolina Xavier; Rodrigo A. Cunha; Huibert D. Mansvelder; Samira G. Ferreira. "Adenosine A2A Receptors Control Glutamatergic Synaptic Plasticity in Fast Spiking Interneurons of the Prefrontal Cortex". Frontiers in Pharmacology 9 (2018): https://doi.org/10.3389%2Ffphar.2018.00133.
    10.3389/fphar.2018.00133
  3. Joana Real; Caroline Miranda; Charlotta S. Olofsson; Paul A. Smith. "Lipophilicity predicts the ability of nonsulphonylurea drugs to block pancreatic beta-cell KATP channels and stimulate insulin secretion; statins as a test case". Endocrinology, Diabetes & Metabolism (2018): e00017-e00017. https://doi.org/10.1002%2Fedm2.17.
    10.1002/edm2.17
  4. Real JI; Simões AP; Cunha RA; Ferreira SG; Rial D. "Adenosine A2A receptors modulate the dopamine D2 receptor-mediated inhibition of synaptic transmission in the mouse prefrontal cortex.". The European journal of neuroscience (2018): http://europepmc.org/abstract/med/29570875.
    10.1111/ejn.13912
  5. Simões AP; Silva CG; Marques JM; Pochmann D; Porciúncula LO; Ferreira S; Oses JP; et al. "Glutamate-induced and NMDA receptor-mediated neurodegeneration entails P2Y1 receptor activation.". Cell death & disease (2018): http://europepmc.org/abstract/med/29463792.
    10.1038/s41419-018-0351-1
  6. Paula M. Canas; Lisiane O. Porciúncula; Ana Patrícia Simões; Elisabete Augusto; Henrique B. Silva; Nuno J. Machado; Nélio Gonçalves; et al. "Neuronal adenosine A2A receptors are critical mediators of neurodegeneration triggered by convulsions". eneuro (2018): ENEURO.0385-18.2018. https://doi.org/10.1523%2Feneuro.0385-18.2018.
    10.1523/eneuro.0385-18.2018
  7. Nunez Duran E; Chanclon B; Sütt S; Real J; Marschall HU; Wernstedt-Asterholm I; Cansby E; Mahlapuu M. "Protein kinase STK25 aggravates the severity of non-alcoholic fatty pancreas disease in mice.". (2017): http://europepmc.org/abstract/med/28442507.
    10.1530/joe-17-0018
  8. Rial D; Morató X; Real JI; Gonçalves FQ; Stagljar I; Pereira FC; Fernández-Dueñas V; Cunha RA; Ciruela F. "Parkinson's disease-associated GPR37 receptor regulates cocaine-mediated synaptic depression in corticostriatal synapses.". (2016): http://europepmc.org/abstract/med/28007645.
    10.1016/j.neulet.2016.12.040
  9. Matheus, F.C.; Rial, D.; Real, J.I.; Lemos, C.; Ben, J.; Guaita, G.O.; Pita, I.R.; et al. "Decreased synaptic plasticity in the medial prefrontal cortex underlies short-term memory deficits in 6-OHDA-lesioned rats". Behavioural Brain Research 301 (2016): 43-54. http://www.scopus.com/inward/record.url?eid=2-s2.0-84951803833&partnerID=MN8TOARS.
    10.1016/j.bbr.2015.12.011
  10. Rial, D.; Lemos, C.; Pinheiro, H.; Duarte, J.M.; Gonçalves, F.Q.; Real, J.I.; Prediger, R.D.; et al. "Depression as a glial-based synaptic dysfunction". Frontiers in Cellular Neuroscience 9 JAN2016 (2016): 1-11. http://www.scopus.com/inward/record.url?eid=2-s2.0-84957876863&partnerID=MN8TOARS.
    10.3389/fncel.2015.00521
  11. Ferreira DG; Batalha VL; Vicente Miranda H; Coelho JE; Gomes R; Gonçalves FQ; Real JI; et al. "Adenosine A2A Receptors Modulate a-Synuclein Aggregation and Toxicity.". (2015): http://europepmc.org/abstract/med/26534909.
  12. Matheus FC; Rial D; Real JI; Lemos C; Takahashi RN; Bertoglio LJ; Cunha RA; Prediger RD. "Temporal Dissociation of Striatum and Prefrontal Cortex Uncouples Anhedonia and Defense Behaviors Relevant to Depression in 6-OHDA-Lesioned Rats.". (2015): http://europepmc.org/abstract/med/26164273.
    10.1007/s12035-015-9330-z
  13. Li, W.; Silva, H.B.; Real, J.; Wang, Y.-M.; Rial, D.; Li, P.; Payen, M.-P.; et al. "Inactivation of adenosine A2A receptors reverses working memory deficits at early stages of Huntington's disease models". Neurobiology of Disease 79 (2015): 70-80. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929459097&partnerID=MN8TOARS.
    10.1016/j.nbd.2015.03.030
  14. Costa, A.R.; Real, J.; Antunes, C.M.; Cruz-Morais, J.. "A new approach for determination of Na,K-ATPase activity: Application to intact pancreatic ß-cells". In Vitro Cellular and Developmental Biology - Animal 46 1 (2010): 7-10. http://www.scopus.com/inward/record.url?eid=2-s2.0-77949274512&partnerID=MN8TOARS.
    10.1007/s11626-009-9243-0
Thesis / Dissertation
  1. Real, Joana Isabel Estudante Batista. "Regulação da atividade elétrica da célula ß-pancreática por canais de K+ sensíveis a Ca2+". PhD, 2013. http://hdl.handle.net/10316/23798.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2018/06/22 Adiponectin increases glucose-dependent electrical activity and insulin secretion in mouse pancreatic ß-cells 78th Scientific Sessions of American Diabetes Association, Orlando, FL, USA
American Diabetes Association (Florida, United States)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2018 - 2019 Role of Purinergic Receptors on Glucose-Induced Insulin Secretion
Supervisor
 Master (Master)
Göteborgs universitet Sahlgrenska Akademin, Sweden
2016 - 2019 The role of intra-islet paracrine communication in the development of type-2 diabetes.
Co-supervisor
 PhD (PhD)
Göteborgs universitet Sahlgrenska Akademin, Sweden
2017 - 2018 Role of fatty acid synthase in glucagon secretion in alpha TC1 clone 6 cells.
Supervisor
 Master (Master)
Göteborgs universitet Sahlgrenska Akademin, Sweden
2010 - 2011 Action of TEA on K+ currents in pancreatic beta-cells
Co-supervisor
 Bioquímica (Degree)
Universidade de Coimbra, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2017/12 PhD Half-time: The effect of extracellular calcium on neuronal excitability. Supervisor: Eric Hanse
(Thesis) Arguer
 My Forsberg (PhD)
Göteborgs universitet Sahlgrenska Akademin, Sweden

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2017 - 2020 Title: Going through Non beta-cells of the pancreas Course and examination for medical students (Licence) Göteborgs universitet Sahlgrenska Akademin, Sweden
Distinctions

Other distinction

2014 Prémios Santa Casa Neurociências 2014 (Neuromodelation Group from CNC - Doutor Rodrigo Cunha)