Joana Margarida Silva (0311-6DFB-0B95)

Curriculum Vitae

Joana Margarida Silva

I am an early career team leader at the ICVS, School of Medicine/University of Minho. I hold a BSc in Biology, and an MSc in Molecular Genetics. I did my PhD training in Dr. Ioannis Sotiropoulos and Prof. Nuno Sousa's Lab where I studied how stress impacts Tau degradation mechanisms showing that chronic stress and high GCs inhibit the autophagy and dysregulate RNA-binding proteins (RBPs) homeostasis leading Tau pathology and downstream memory loss (Silva JM et al., Cell DD 2019). In addition, I also introduced a novel mechanism of GC-driven synaptic degeneration via synaptic missorting of Tau and glutamatergic excitotoxic signaling (Pinheiro S*, Silva J* et al., 2015 Mol Neurob). In parallel to studying Tau pathology, I also focused my Ph.D. studies on understanding Tau function in the brain. I identified a novel role of Tau on epigenetic homeostasis showing that loss of Tau triggers neuronal malfunction/atrophy through the dysregulation of nuclear epigenetic mechanisms (Silva JM, et al 2024, under revision in Nature Neuroscience). In parallel to my Ph.D. work, I also participated in other studies analyzing Tau-related brain damage by stress (e.g. Dioli et al., Mol Psych 2017, Vaz-Silva J et al., EMBO 2018). Next, obtaining my funding and post-doc fellowship from Canon Foundation (2018), I extended my international training by working at the lab of Prof Takashima (Imperial University, Japan), a well-known expert in the field of Tau biology, where I further monitored different parameters of Tau role in nucleus related to RBPs. I returned to ICVS as an Assistant Researcher in the Brain Circuits and Neuron-glia Adaptations Team (CEEC Individual 2022). I am now a Research Assistant developing my research line on understanding the role of RNA metabolism and the pathological load of RNA granules in stress-driven brain pathologies such as AD, depression, and Down Syndrome. I actively supervise students from different levels ( 1 Ph.D. candidate, 4 MSc students, and undergrad). I've recently received National funding for the research project "Novel methods for blood biomarker detection for AD", in collaboration with C2A and INL, and FCT Contract for Junior Researcher 2021.00204.CEECCIND, to start my Lab, focusing on the Unique biology of RNA-granules in vulnerability and treatment of brain pathologies, awarded by the Portuguese Foundation for Science, highly competitive with an 8% approval rate. My publication list includes high-impact factor publications.

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Identification

Personal identification

Full name: Joana Margarida Silva

Citation names

Silva, Joana
Silva, JM

Author identifiers

Ciência ID: 0311-6DFB-0B95
ORCID iD: 0000-0002-8257-3413

Email addresses

joanamsilva@med.uminho.pt (Professional)

Telephones

Telephone

(+351) 253604831 (Professional)
(+351) 253604835 (Professional)

Addresses

School of Medicine, University of Minho, 4710-057, Braga, Braga, Portugal (Professional)

Websites

https://icvs.uminho.pt/member/joana-margarida-silva/ (Professional)

Knowledge fields

Medical and Health Sciences - Basic Medicine - Neurosciences
Natural sciences - Biological Sciences - Cell Biology

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)
French	Beginner (A1)	Elementary (A2)	Beginner (A1)	Elementary (A2)	Beginner (A1)

Education

	Degree	Classification
2013/01/01 - 2017/03/27 Concluded	Health Sciences (Doutoramento) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal Universidade do Minho Escola de Medicina, Portugal "Tau (mal)function in brain plasticity and pathology – a gateway beyond Alzheimer’s Disease" (THESIS/DISSERTATION)	Highest Degree
2010/09/01 - 2012/11/30 Concluded	Molecular Genetics (Mestrado) Universidade do Minho Departamento de Biologia, Portugal Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal "Neurodegenerative role of stress and glucocorticoid hormones through Alzheimer’s disease tau protein: a proteomic link between stress and brain pathology" (THESIS/DISSERTATION)	18
2007/09/24 - 2010/05/06 Concluded	Applied Biology (Licenciatura) Universidade do Minho Departamento de Biologia, Portugal	13

Affiliation

Science

	Category Host institution	Employer
2022/09/01 - 2028/08/31	Contracted Researcher (Research)	Escola de Medicina, University of Minho, Portugal
	Laboratório Associado ICVS 3B's, Portugal (...)
2019/02/15 - 2022/08/31	Postdoc (Research)	Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

2018/02/01 - 2018/12/01	Postdoc (Research)	Gakushuin University - Department of Life Sciences, Japan

2017/09/01 - 2018/02/28	Postdoc (Research)	Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

2017/04/01 - 2017/08/31	Researcher (Research)	BnML Behavioral and Molecular Lab Lda, Portugal

2012/01/01 - 2017/03/27	Researcher (Research)	Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Teaching in Higher Education

	Category Host institution	Employer
2018/01/09 - Current	Invited Associate Professor (University Teacher)	Escola de Medicina, University of Minho, Portugal

Projects

Grant

	Designation	Funders
2022/10/01 - 2025/09/30	Detection of AD markers in blood samples 2022.04850.PTDC Co-Principal Investigator (Co-PI) Escola de Medicina, University of Minho, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2020/09/01 - 2024/08/31	Uncovering stress induced mechanisms of Tau pathology in Alzheimers Disease NIH_G15190 Co-Principal Investigator (Co-PI) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal Escola de Medicina, University of Minho, Portugal	National Institutes of Health Office of Disease Prevention Ongoing
2020/02/14 - 2020/11/12	Synaptic Networks and Personalized Medicine Approaches to Understand Neurobehavioural Diseases Across Lifespan MedPERSYST Post-doc Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018/02/01 - 2019/01/31	Unmasking the role of Tau protein in adult brain homeostasis: a novel approach for new answers CANON_2017_JS Post-doc Fellow Gakushuin University - Department of Life Sciences, Japan	Canon Europe NV Concluded
2017/09/01 - 2018/01/31	Tau Therapeutics in Down syndrome & Alzheimer's Disease synaptic pathology 520101.ID2021/2017 Post-doc Fellow Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal Laboratório Associado ICVS 3B's, Portugal	Fondation Jérôme Lejeune Ongoing

Contract

	Designation	Funders
2022/10/24 - 2028/10/23	The Unique Biology of RNA granules in Stress and Alzheimer's disease brain pathology 2021.00204.CEECIND Principal investigator	Fundação para a Ciência e a Tecnologia Ongoing
2021/01/01 - 2025/12/31	ICVS/3B¿s - Associate Laboratory, Life and Health Sciences Research Institute / Biomaterials, Biodegradables and Biomimetics Research Group LA/P/0050/2020 10.54499/LA/P/0050/2020 Universidade do Minho, Portugal Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2019/01/01 - 2019/12/31	ICVS/3B's - Laboratório Associado, Instituto de Ciências da Vida e da Saúde / Grupo de Investigação em Biomateriais, Biodegradaveis e Biomiméticos UID/Multi/50026/2019 Universidade do Minho, Portugal Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2017/04/01 - 2019/03/31	A novel modulator of AMPA receptors against Alzheimer's Disease pathology: the first in vivo evidence Servier_ICVS_2017_003 Post-doc Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal Laboratório Associado ICVS 3B's, Portugal	Laboratoires Servier Industrie Ongoing
2011/08/01 - 2015/01/31	Mecanismos comuns às alterações de humor e disfunção cognitiva induzidos pelo stress - da depressão à doença de alzheimer. PTDC/SAU-NMC/113934/2009 Universidade do Minho, Portugal Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Other

	Designation	Funders
2019/01/02 - 2020/01/31	WINERVED - Wireless NEural Repair Via Electric and Drug delivery. ICVS/INL_2018_WiNERVE Principal investigator Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal Laboratório Associado ICVS 3B's, Portugal	Laboratório Associado ICVS 3B's Ongoing
2016/01/01 - 2017/12/31	Tau Therapeutics in stress-evoked brain pathology: exploring the path from depression to Alzheimer´s disease. Janssen Prize 2016 PhD Student Fellow Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal Laboratório Associado ICVS 3B's, Portugal
2011/01/01 - 2013/12/31	Mechanistic Link between stress-induced mood and cognitive dysfunction - The path from depression to Alzheimer's Disease. 520101.ID1415/2011 Researcher Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal Laboratório Associado ICVS 3B's, Portugal
2011/05/01 - 2013/04/30	Common mechanisms to cognitive dysfunction and mood disorders induced by stress - from Depression to Alzheimer. PTDC/SAU-NMC/113934/2009 Master Student Fellow Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal Laboratório Associado ICVS 3B's, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Outputs

Publications

Book chapter	Ioannis Sotiropoulos; Joana Margarida Silva; Patricia Gomes; Nuno Sousa; Osborne FX Almeida. "Chronic Stress and Glucocorticoids". In Tau Biology, edited by Akihiko Takashima; Benjamin Wolozin; Luc Buee. Singapore: Springer Singapore, 2020. Published • 10.1007/978-981-32-9358-8 Vyas, S.; Rodrigues, A.J.; Silva, J.M.; Tronche, F.; Sousa, N.; Sotiropoulos, I.. "Glucocorticoids and neurodegeneration". In Adrenal Glands, edited by Gaetano Santulli. Springer Berlin Heidelberg, 2005.
Conference abstract	Gomes, A.P.; VAz-Silva, J.; Quintremil, S.; Silva, Joana; Sousa, N.; Waites, C.; Sotiropoulos, I.. "Implication of Rab35/ESCRT pathway in tau proteostasis under control and pathological conditions". Paper presented in ECNP 2019, Copenhagen, 2019. Published Fernandes, D.; Silva, Joana; Sotiropoulos, I.; Bretin, S.. "A novel modulator of AMPA receptors against Alzheimer's Disease pathology: the first in vivo evidence". Paper presented in ECNP Workshop 2018, Nice, 2018. Published Sotiropoulos, I.; Rodrigues, Sara; Silva, Joana; Wolozin, B.; Sousa, N.. "ENVIRONMENTAL STRESS AND GLUCOCORTICOIDS TRIGGER AN HDAC6-DEPENDENT INDUCTION OF STRESS GRANULES AND TAU AGGREGATION: IMPLICATIONS FOR ALZHEIMER'S DISEASE". Paper presented in Alzheimer's Association 2016, Nice, 2016. Published Silva, Joana; Rodrigues, Sara; Marques, M.B.; Ludovico, P; Sousa, N.; Sotiropoulos, I.; Almeida, O.F.X.; Takashima, A.. "The stressed autophagy: chronic stress exacerbates Tau pathology by blocking autophagy clearance system". Paper presented in ECNP Workshop 2016, Nice, 2016. Published Sotiropoulos, I.; Lopes, S.; VAz-Silva, J.; Silva, Joana; Rodrigues, Sara; Almeida, O.F.X.; Sousa, N.. "Microtubule-associated protein tau is important for stress-driven depressive pathology and cognitive deficits". Paper presented in Alzheimer's Association 2015, 2015. Published
Conference poster	Megalokonomou, A; Campos-Marques, Carlos; Godinho, B; Watts, J; Samiotaki, M; Panayotou, G; Papadimitriou, G.; et al. "Antisense oligonucleotide (ASOs) therapeutic approach against Tau-driven neuronal pathology in Alzheimer's disease brain pathology.". Paper presented in 30th Meeting of the Hellenic Society for Neuroscience (HSfN), 2023. Campos-Marques, Carlos; Godinho, Bruno; Watts, Jonathan K; Sousa, Nuno; Sotiropoulos, Ioannis; Silva, Joana. "A novel RNA-targeted therapeutic approach against Tau-driven neuronal pathology in Alzheimer's and Down syndrome brain pathologies". Paper presented in ISN-ESN Meeting, 2023. Nóbrega-Martins, Rita; Guedes, Sofia; Udochukwu, Lucian; Santos, Beatriz; Campos-Marques, Carlos; Silva, Iara; Maciel, Patrícia; et al. "Therapeutical potential of tauroursodeoxycholic acid in stress-related brain pathologies". Paper presented in ISN-ESN 2023 Meeting, 2023. Neves-Carvalho, Andreia; Duarte-Silva, S; Silva, JM; Almeida, Bruno; Heetveld, S; Sotiropolous, I; Heutink, P; et al. "Regulation of neuronal mRNA splicing and of Tau isoforms ratio by ATXN3 through deubiquitylation of splicing factors". Paper presented in RNA Meeting: ptRNA2019, 2019. Silva, Joana; Gomes, A.P.; Jose Miguel Pego; Hugo Leite-Almeida; Sousa, N.; Sotiropoulos, I.. "Molecular mechanisms of post-anesthesia cognitive deficits and Tau protein". Paper presented in EuroTau Meeting 2018, Lille (France), 2018. Silva, Joana; Rodrigues, Sara; Marques, M.B.; Gomes, A.P.; Neves-Carvalho, A.; Soares-Cunha, C.; Takashima, A.; et al. "Chronic stress triggers Tau pathology through autophagy inhibition and induction of stress granules". Paper presented in XV Portuguese Society for Neuroscience, Braga (Portugal), 2017. Silva, Joana; Rodrigues, A.J.; Soares-Cunha, C.; Sousa, N.; Sotiropoulos, I.. "Conditional ablation of Tau in the adult brain leads to anxious and depressive pathology". Paper presented in SfN 2016, San Diego (USA), 2016. Silva, Joana; Rodrigues, Sara; Marques, M.B.; Ludovico, P; Almeida, O.F.X.; Takashima, A.; Sousa, N.; Sotiropoulos, I.; Soares-Cunha, C.. "The “stressed” autophagy: chronic stress exacerbates Tau pathology by blocking autophagy clearance system". Paper presented in ECNP Workshop for Junior Scientists, Nice (France), 2016. Silva, Joana; Rodrigues, Sara; Marques, M.B.; Ludovico, P; Almeida, O.F.X.; Takashima, A.; Sousa, N.; Sotiropoulos, I.. "The “stressed” autophagy: chronic stress blocks autophagy in a model of Tau pathology". Paper presented in XIV Sociedade Portugesa de Neurociências, Póvoa do Varzim (Portugal), 2015. Silva, Joana; Marques, M.B.; Ludovico, P; Pinto, V.; Sousa, N.; Sotiropoulos, I.. "Stressed Proteostasis: chronic stress impact on the orquestration of chaperone mediated proteosomal and autophagic pathways in Alzheimer’s Disease pathology". Paper presented in EMBO Workshop - Ma’ale Hachamisha (Israel), 2014. Silva, Joana; Pinheiro, S.; Pinto, V.; Sousa, N.; Sotiropoulos, I.. "Structural dynamics of synapses: the role of TAU and its vulnerability f to stress hormones". Paper presented in XIII Sociedade Portuguesa de Neurociências (SPN) Meeting, 2013. Silva, Joana; Sotiropoulos, I.; Rodrigues, A.J.; Almeida, O.F.X.; Takashima, A.; Sousa, N.. "Dissecting the role of stress on cognitive and emotional components of Tau-related AD pathology: Is gender important?". Paper presented in SfN 2012, 2012. Silva, Joana; Sotiropoulos, I.; Kimura, T.; Takashima, A.; Sousa, N.. "Mechanisms of Tau aggregation and degradation: what does it change by chronic stress?". Paper presented in The Federation of European Neuroscience Society 2012, 2012. Silva, Joana; Sotiropoulos, I.; Rodrigues, A.J.; Almeida, O.F.X.; Takashima, A.; Sousa, N.. "Chronic Stress aggravates insoluble tau accumulation in P301L-tau Tg mice: a gender-based study and its implications in human tauopathies". Paper presented in SINAL 2012, 2012.
Journal article	Carlos Marques; Anastasia Megalokonomou; Beatriz Barros Santos; Rta Nóbrega-Martins; Bruno MCD Godinho; Carina Soares-Cunha; Jonathan Lee; et al. Corresponding author: Silva, JM. "Screening of novel ASOs against Tau protein - shifting isoforms". Molecular Therapy (2024): Submitted Brakatselos C; Polissidis AV; Ntoulas G; Asprogerakas MZ; Tsarna O; Vamvaka A; Nakas G; et al. Corresponding author: Antoniou K. "Cannabidiol restores ketamine-induced schizophrenia-like symptomatology by multi-level actions on the underlying neurobiological substrate". Translational Pschiatry (2024): Under revision Luísa Pinto; Joana Macedo, ; Bruna Araújo; Sandra Anjo; Tiago Silveira-Rosa ; Patrícia Patrício; Fábio Teixeira; et al. Corresponding author: Luísa Pinto. "Glial-Restricted Precursors stimulate endogenous cytogenesis and effectively recover emotional deficits in a model of cytogenesis ablation". Molecular Psychiatry (2024): In press Patrícia A. Gomes; Cristian Bodo; Carlos Nogueras-Ortiz; Martina Samiotaki; Minghao Chen; Carina Soares-Cunha; Joana M. Silva; et al. "A novel isolation method for spontaneously released extracellular vesicles from brain tissue and its implications for stress-driven brain pathology". Cell Communication and Signaling (2023): https://doi.org/10.1186/s12964-023-01045-z. 10.1186/s12964-023-01045-z Silva, Joana; Rodrigues, Ana João; Monteiro-Fernandes, Daniela; Lahiri, Shibojyoti; Soares-Cunha, Carina; Oliveira, João; Caetano, Inês; et al. "Loss of function of Tau in the adult brain leads to synaptic dysfunction through nucleosome destabilization". Nature (2023): Under revision Sara R. Guerreiro; Marco R. Guimarães; Joana M. Silva; Chrysoula Dioli; Anastasia Vamvaka-Iakovou; Raquel Sousa; Patrícia Gomes; et al. "Chronic pain causes Tau-mediated hippocampal pathology and memory deficits". Molecular Psychiatry (2022): https://doi.org/10.1038/s41380-022-01707-3. 10.1038/s41380-022-01707-3 Silveira-Rosa, Tiago; Mateus-Pinheiro, António; Correia, Joana Sofia; Silva, Joana Margarida; Martins-Macedo, Joana; Araújo, Bruna; Machado-Santos, Ana Rita; et al. "Suppression of adult cytogenesis in the rat brain leads to sex-differentiated disruption of the HPA axis activity". Cell Proliferation 55 2 (2021): http://dx.doi.org/10.1111/cpr.13165. 10.1111/cpr.13165 Loureiro-Campos, Eduardo; Mateus-Pinheiro, António; Patrício, Patrícia; Soares-Cunha, Carina; Silva, Joana; Sardinha, Vanessa Morais; Mendes-Pinheiro, Bárbara; et al. "Constitutive deficiency of the neurogenic hippocampal modulator AP2¿ promotes anxiety-like behavior and cumulative memory deficits in mice from juvenile to adult periods". eLife 10 (2021): http://dx.doi.org/10.7554/elife.70685. 10.7554/elife.70685 Viktoriya Zhuravleva; João Vaz-Silva; Mei Zhu; Patricia Gomes; Joana M. Silva; Nuno Sousa; Ioannis Sotiropoulos; Clarissa L. Waites. "Rab35 and glucocorticoids regulate APP and BACE1 trafficking to modulate Aß production". Cell Death & Disease (2021): https://doi.org/10.1038/s41419-021-04433-w. 10.1038/s41419-021-04433-w Amalric, M; Pattij, T; Sotiropoulos, I; Silva, JM; Sousa, N.; Staou, S; Chiamulera, C; et al. "Where dopaminergic and cholinergic systems interact: a gateway for tuning neurological and psychiatric disorders". Frontiers in Behavioral Neuroscienc (2021): Under revision Monteiro-Fernandes, Daniela; Silva, Joana; Soares-Cunha, Carina; Dalla, Cristina; Kokras, Nikos; François, A; Billiras, R; et al. "Allosteric modulation of AMPA receptors counteracts Tau-related excitotoxic synaptic signaling and memory deficits in Stress and Aß-evoked hippocampal pathology". Journal of Molecular Psychiatry (2020): https://doi.org/10.1038/s41380-020-0794-5. In press • 10.1038/s41380-020-0794-5 Bordone MP, Salman MM, Titus HE, Amini E, Andersen JV, Chakraborti B, Diuba AV, Dubouskaya TG; Ehrke E, Espindola de Freitas A, Braga de Freitas G, Gonçalves RA, Gupta D, Gupta R, Ha SR; Hemming IA, Jaggar M, Jakobsen E, Kumari P, Lakkappa N, Marsh APL, Mitlöhner J, Ogawa Y, Kumar; PR, Ribeiro FC, Salamian A, Saleem S, Sharma S; Silva, Joana; Singh S, Sulakhiya K, Tefera TW, Vafadari B, Yadav A, Yamazaki R, Seidenbecher CI. "The energetic brain - A review from students to students.". Journal of neurochemistry (2019): https://doi.org/10.1111/jnc.14829. Published • 10.1111/jnc.14829 Soares-Cunha, Carina; Vasconcelos, Nivaldo; Coimbra, Barbara; Domingues, Ana Verónica; Silva, Joana; Loureiro-Campos, Eduardo; Gaspar, Rita; et al. "Nucleus accumbens medium spiny neurons subtypes signal both reward and aversion.". Molecular psychiatry (2019): https://doi.org/10.1038/s41380-019-0484-3. Accepted • 10.1038/s41380-019-0484-3 Silva, Joana; Rodrigues, Sara; Sampaio-Marques, Belem; Gomes, Patricia; Neves-Carvalho, Andreia; Dioli, Chrysoula; Soares-Cunha, Carina; et al. "Dysregulation of autophagy and stress granule-related proteins in stress-driven Tau pathology". Cell Death & Diff (2019): Accepted Esteves, Madalena; Almeida, António M.; Silva, Joana; Silva Moreira, Pedro; Carvalho, Emanuel; Pêgo, José Miguel; Almeida, Armando; et al. "MORPhA Scale: Behavioral and electroencephalographic validation of a rodent anesthesia scale". Journal of Neuroscience Methods 324 (2019): 108304. http://dx.doi.org/10.1016/j.jneumeth.2019.05.013. 10.1016/j.jneumeth.2019.05.013 Vaz-Silva, João; Gomes, Patricia; Jin, Q; Zhu, M; Zhuravleva, V; Quintremil, S; Meira, Torcato; et al. "Endolysosomal degradation of Tau and its role in glucocorticoid-driven hippocampal malfunction". EMBO J (2018): Published Duarte-Silva, Sara; Neves-Carvalho, Andreia; Soares-Cunha, Carina; Silva, Joana; Teixeira-Castro, Andreia; Vieira, Rita; Silva-Fernandes, Anabela; Maciel, Patricia. "Neuroprotective Effects of Creatine in the CMVMJD135 Mouse Model of Spinocerebellar Ataxia Type 3". Movement disorders (2018): Published Sotiropoulos I; Galas MC; Silva JM; Skoulakis E; Wegmann S; Maina MB; Blum D; et al. "Atypical, non-standard functions of the microtubule associated Tau protein.". Acta neuropathologica communications (2017): http://europepmc.org/abstract/med/29187252. 10.1186/s40478-017-0489-6 Dioli, C.; Patrício, P.; Trindade, R.; Pinto, L.G.; Silva, J.M.; Morais, M.; Ferreiro, E.; et al. "Tau-dependent suppression of adult neurogenesis in the stressed hippocampus". Molecular Psychiatry 22 8 (2017): 1110-1118. http://www.scopus.com/inward/record.url?eid=2-s2.0-85026899195&partnerID=MN8TOARS. 10.1038/mp.2017.103 Silva, Joana; Pinheiro, Sara; Mota, Cristina; Vaz-Silva, João; Veloso, Ana; Pinto, Vitor; Sousa, Nuno; Cerqueira, João; Sotiropoulos, Ioannis. "Tau Mislocation in Glucocorticoid-Triggered Hippocampal Pathology.". Molecular neurobiology (2016): http://europepmc.org/abstract/med/26328538. Published • 10.1007/s12035-015-9356-2 Moreira, PS; Sotiropoulos, I.; Silva, Joana; Akihiko Takashima; Sousa, Nuno; Leite-Almeida, Hugo; Costa, Patricio. "The Advantages of Structural Equation Modeling to Address the Complexity of Spatial Reference Learning.". Frontiers in behavioral neuroscience (2016): http://europepmc.org/abstract/med/26955327. Published • 10.3389/fnbeh.2016.00018 Mateus-Pinheiro, A.; Alves, N.D.; Patrício, P.; Machado-Santos, A.R.; Loureiro-Campos, E.; Silva, J.M.; Sardinha, V.M.; et al. "AP2¿ controls adult hippocampal neurogenesis and modulates cognitive, but not anxiety or depressive-like behavior". Molecular Psychiatry (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84992390012&partnerID=MN8TOARS. 10.1038/mp.2016.169 Vyas, S.; Rodrigues, A.J.; Silva, J.M.; Tronche, F.; Almeida, O.F.X.; Sousa, N.; Sotiropoulos, I.. "Chronic stress and glucocorticoids: From neuronal plasticity to neurodegeneration". Neural Plasticity 2016 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84962129187&partnerID=MN8TOARS. 10.1155/2016/6391686 Sotiropoulos, Ioannis; Silva, Joana; Kimura, T; Rodrigues, AJ; Costa, Patricio; Almeida, OFX; Sousa, Nuno; Takashima, A. "Female hippocampus vulnerability to environmental stress, a precipitating factor in Tau aggregation pathology.". Journal of Alzheimer's disease : JAD (2015): http://europepmc.org/abstract/med/25159665. Published • 10.3233/jad-140693
Thesis / Dissertation	Silva, Joana. "Tau (mal)function in brain plasticity and pathology: a gateway beyond Alzheimer's Disease". PhD, Universidade do Minho, 2017. http://repositorium.sdum.uminho.pt/handle/1822/48703. Silva, Joana. "Neurodegenerative role of stress and glucocorticoid hormones trought Alzheimer's disease Tau protein : a proteomic link between stress and brain pathology". Master, Universidade do Minho, 2012. http://repositorium.sdum.uminho.pt/handle/1822/22819.

Artistic / Performance

Visual artwork

Silva, Joana. CNIDÁRIOS: Hidras, Medusas, Anémonas e Corais / PHYLUM CNIDARIA: Cnidarians, Hydras, Anemones and Corals..
Silva, Joana. Esponjas/Sponges.

Other

Other output

Regulation of neuronal mRNA splicing and Tau isoform ratio by ATXN3 through deubiquitylation of splicing factors. 2019. Neves-Carvalho, Andreia; Sara, Duarte-Silva; Silva, Joana; Almeida, Bruno; Heetveld, S; Sotiropoulos, Ioannis; Heutink, P; Li, KW; Maciel, Patricia. http://dx.doi.org/10.1101/711424.
10.1101/711424

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2023/03/30	The role of Tau in translational stress response and its importance for brain pathology	AD/PD Meeting 2023 (Gotemburg, Sweden)
2019/07/10	Chronic stress as a precipitating factor in Alzheimer’s Disease brain pathology: from synapses to networks	FENS Regional Meeting 2019 (Belgrade, Serbia)
2018/06/21	Chronic stress triggers Tau pathology through autophagy inhibition and induction of stress granules	IAND Workshop (Lisbon, Portugal)
2018/06/04	Tau (mal)function in brain plasticity and pathology.	Ciência Falada 2018 Life and Health Sciences Research Institute (Braga, Portugal)
2017/04/29	Tau protein is essential for stress-driven depressive pathology and cognitive deficits	13th International Conferences ADPD 2017 (Vienna, Austria)
2017/03/29	The “stressed” autophagy: chronic stress exacerbates Tau pathology by blocking autophagy clearance system	13th International Conferences ADPD 2017 (Vienna, Austria)
2016/09/17	The “stressed” autophagy: chronic stress exacerbates Tau pathology by blocking autophagy clearance system	29th ECNP Congress (Vienna, Austria)
2015/03/18	Tau missorting as part of glucocorticoid-triggered synaptic pathology	AD/PD Meeting, Nice (France) (Nice, France)
2012/01/05	Stress, Amyloid-ß and Tau: the triangle of oblivion	The biology and pathology of Tau and its role in tauopathies II (Cambridge, United Kingdom)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2024/04/01 - 2028/03/31	Tau targeting ASOs against Down Syndrome brain pathology Supervisor of Carlos Marques	PhD in Health Sciences (PhD) Universidade do Minho Escola de Medicina, Portugal
2022/05/01 - 2023/12/16	The use of a novel conditional mouse model to study Tau role in newly born neurons Supervisor	Health Sciences (Master) Escola de Medicina, University of Minho, Portugal
2022/05/01 - 2023/12/15	The role of RNA granules and TIA-1 in stress-related brain pathologies Supervisor	Molecular Genetics (Master) Universidade do Minho Departamento de Biologia, Portugal
2022/05/01 - 2023/12/14	TUDCA as a novel therapeutic approach for depression Supervisor of Rita Nóbrega Amaral Martins	Molecular Genetics (Master) Universidade do Minho Departamento de Biologia, Portugal
2022/04/01 - 2023/10/31	Tau protein in CRH neurons as a modulator of memory consolidation Supervisor	Health Sciences (Master) Escola de Medicina, University of Minho, Portugal
2019/01/05 - 2021/11/06	Tau therapeutics in Down Syndrome & Alzheimer’s Disease synaptic pathologies Supervisor of Carlos Marques	Master in Health Sciences (Master) Escola de Medicina, University of Minho, Portugal
2021/04/01 - 2021/06/30	Tau protein ablation in the adult brain and its impact on hippocampal neurogenesis Supervisor of Iara Rodrigues	Applied Biology (Degree)
2021/04/01 - 2021/06/30	RNA Binding Proteins, Stress Granules and Tau pathology in a transgenic mouse model of neurodegeneration Supervisor	Applied Biology (Degree)
2017/09/01 - 2018/06/15	A novel role for tau protein in the mechanisms of brain damage caused by peripheral neuropathy Co-supervisor of Sara Francisca Guerreiro	Master in Health Sciences (Master) Escola de Medicina, University of Minho, Portugal
2017/09/01 - 2018/06/14	A novel modulator of AMPA receptors against Alzheimer's Disease pathology: the first in vivo evidence Co-supervisor of Daniela Monteiro Fernandes	Master in Health Sciences (Master) Escola de Medicina, University of Minho, Portugal
2017/10/01 - 2017/12/31	The role of Tau protein in anesthetics function and post-anesthesia cognitive deficits Co-supervisor of Emanuel Carvalho	Integrated Master in Medical Sciences (Master) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal Escola de Medicina, University of Minho, Portugal
2016/05/01 - 2016/06/30	The interplay between peripheral neuropathy and Tau protein in neuronal and synaptic damage in the brain Co-supervisor of Sara Guerreiro	Bachelor in Biochemistry (Scientific initiation) Universidade do Minho Departamento de Biologia, Portugal
2016/05/01 - 2016/06/30	Molecular mechanisms of post-anesthesia cognitive deficits and Tau protein Co-supervisor of Damiana Rodrigues	Bachelor in Biochemistry (Scientific initiation) Universidade do Minho Departamento de Biologia, Portugal
2016/05/01 - 2016/06/30	Role of Tau protein in hippocampal function under chronic pain conditions Co-supervisor of Rita Nunes	Bachelor in Biochemistry (Scientific initiation) Universidade do Minho Departamento de Biologia, Portugal
2016/05/01 - 2016/06/30	Role of conditional Tau deletion in brain structure and function Co-supervisor of Daniela Monteiro Fernandes	Bachelor in Biochemistry (Scientific initiation) Universidade do Minho Departamento de Biologia, Portugal
2015/05/01 - 2015/06/30	The role of Tau protein in anesthetics function and post-anesthesia cognitive deficits - behavior read-outs Co-supervisor of Rita Sousa	Bachelor in Biochemistry (Scientific initiation) Universidade do Minho Departamento de Biologia, Portugal
2015/05/01 - 2015/06/30	The role of Tau protein in anesthetics function and post-anesthesia cognitive deficits - Neurostructural read-outs Co-supervisor of Kevi Rodrigues	Bachrlor in Biochemistry (Scientific initiation) Universidade do Minho Departamento de Biologia, Portugal
2014/05/01 - 2014/06/30	Structural and functional dynamics of synapse: the role of Mapt in neuronal and brain aging Co-supervisor of Barbara Barbosa	Bachelor in Biochemistry (Scientific initiation) Universidade do Minho Departamento de Biologia, Portugal

Event organisation

	Event name Type of event (Role)	Institution / Organization
2012/03/09 - Current	Brain awareness week (2012/03/09) Festival (Co-organisor)	Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2024/04/03 - 2024/04/17	SINGLE-CELL GENOMICS FOR BEGINNERS 2nd Edition (2024/04/03 - 2024/04/17) Workshop (President of the Organising Committee)	Escola de Medicina, University of Minho, Portugal
2024/03/11 - 2024/03/17	Brain Awareness Week (2024/03/11 - 2024/03/17) Round table (Co-organisor)	Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2023/09/29 - 2023/09/29	2023 European Researchers’ Night (2023/09/29 - 2023/09/29) Festival (Co-organisor)	Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2023/07/01 - 2023/07/05	Summer on Campus (2023/07/01) Workshop (Member of the Organising Committee)	Universidade do Minho, Portugal
2022/03/31 - 2022/04/12	SINGLE-CELL GENOMICS FOR BEGINNERS 1st Edition (2022/03/31 - 2022/04/12) Workshop (Member of the Organising Committee)	Escola de Medicina, University of Minho, Portugal
2020/10/01 - 2021/06/07	EMBO Practical Course Single-cell genomics - Get Started! (2021/06/01 - 2021/06/07) Meeting (Co-organisor)	Universidade do Minho, Portugal
2018/05/01 - 2019/08/31	European Behavior Neuroscience Meeting 2019, Braga (Portugal) (2019/08/27 - 2019/08/31) Conference (Member of the Organising Committee)	Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2017/03/01 - 2017/05/31	XV Portuguese Society for Neuroscience, Braga (Portugal) (2017/05/25 - 2017/05/26) Congress (Other)	Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2013/01/01 - 2013/10/31	Current Aspects in Pathophysiology of Alzheimer’s Disease: What do we miss?, Braga (Portugal) (2013/10/24 - 2013/10/26) Workshop (Member of the Organising Committee)	Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2009/01/01 - 2009/05/31	Applied Biology Conference 2009, Braga (Portugal) (2009/05/07 - 2009/05/10) Symposium (Member of the Organising Committee)	Universidade do Minho, Portugal

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2024/01/19	Secretome-loaded piezoelectric hydrogels as advanced biomaterials to modulate neuronal and glial activity Thesis Member	Tiffany Pinho (PhD) Universidade do Minho Escola de Medicina, Portugal
2024/01/16	Interneuron characterization in Rett Syndrome: insights from mice prefrontal cortex (Thesis) Arguer	Isabella França Santos de Oliveira (Master) Escola de Medicina, University of Minho, Portugal
2023/12/22	The role of insulin signalling in Alzheimer’s disease (Thesis) Main arguer	Steven Alves (PhD) Universidade de Aveiro Instituto de Biomedicina, Portugal

Ad Hoc journal article review

	Journal title (ISSN)	Publisher
2023/06/01 - Current	Nature Neuroscience
2023/05/01 - 2023/12/04	Scientific Reports
2023/03/01 - 2023/05/03	Aging Brain

Committee member

	Activity description Role	Institution / Organization
2023/02/01 - Current	Scientific Outreach Activities Coordinator	Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal Escola de Medicina, University of Minho, Portugal

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2024/09/01 - Current	Foundations of Medicine 1 - Case-Based Learning (CBL)	Medicine (Mestrado integrado) (Mestrado integrado)	Escola de Medicina, University of Minho, Portugal
2023/01/09 - Current	Foundations of Medicine 4 - Case-Based Learning (CBL)	Medicine (Mestrado integrado) (Mestrado integrado)	Escola de Medicina, University of Minho, Portugal
2020/09/05 - Current	Fundamentals in Neuroscience	Neuroscience (Pós-Graduação)	Universidade do Minho, Portugal
2018/10/12 - Current	Seminar in "Molecular Genetics" Post-graduation class: "Tau function and dysfunction in the adult brain."	Seminars in Molecular Genetics (Mestrado)	Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal
2018/05/17 - Current	Seminars in Animal Physiology: "Tau function and malfunction in the adult brain."	Animal Physiology (Licenciatura)	Universidade do Minho Departamento de Biologia, Portugal
2017/12/03 - Current	Seminars in "Applied Animal Biology: "Animal models to study brain pathology."	Applied Animal Physiology (Licenciatura)	Universidade do Minho Departamento de Biologia, Portugal
2016/12/06 - Current	Seminars in Applied Animal Biology: "Tau function and dysfunction in the adult brain: from KOs to transgenics."	Applied Animal Biology (Licenciatura)	Universidade do Minho Departamento de Biologia, Portugal
2013/11/01 - Current	Practical Classes in Laboratory Animal Sceinces	Laboratory Animal Sciences (Curso de mestrado (conclusão do curso de especialização))	Escola de Medicina, University of Minho, Portugal
2017/04/01 - 2018/04/22	Teaching staff in "Hands on the rodent Brain"	Hands on the rodent Brain (Curso de mestrado (conclusão do curso de especialização))	Escola de Medicina, University of Minho, Portugal

Evaluation committee

	Activity description Role	Institution / Organization	Funding entity
2023/03/01 - 2023/05/15	Project Evaluator for Graduate Women in Science Evaluator
2021/02/25 - 2021/10/25	Project Evaluator for Graduate Women in Science Evaluator	Graduate Women in Science, United States	Graduate Women in Science

Mentoring / Tutoring

	Topic	Student name
2017/08/01 - Current	MD Laboratory Rotations	Juliana Fiúza
2019/11/01 - 2020/03/31	Stress-driven changes in synaptic interactome: a link between depression and Alzheimer’ s disease	Ana Catarina Ferreira
2019/02/01 - 2019/02/28	Laboratory Animal Sciences' Lab Rotation	Carlos Marques
2018/03/01 - 2018/03/31	Laboratory Animal Sciences' Lab Rotation	João Oliveira
2017/03/01 - 2017/03/31	Laboratory Animal Sciences' Lab Rotation	Daniela Monteiro Fernandes
2017/03/01 - 2017/03/31	Laboratory Animal Sciences' Lab Rotation	Sara Guerreiro

Distinctions

Award

2023	IBRO International Travel Award International Brain Research Organization, France
2022	Travel Award to attend ISN International Meeting 2022 International Society for Neurochemistry (ISN), United States
2017	Junior Faculty Award International Conference on Alzheimer’s Disease and Parkinson’s Disease, Austria
2017	2018 Canon Foundation Post-Doc Fellowship, Gakushuin University, Tokyo, Japan Canon Foundation in Europe, Netherlands
2012	PhD Fellowship Fundação para a Ciência e a Tecnologia, Portugal

Other distinction

2019	Fellowship Award, 2nd Preclinical Data Network Training Workshop for Young Scientists “How to make preclinical research robust”, Athens Greece European College of Neuropsychopharmacology, Netherlands
2018	Fellowship Award, 2nd ISN Flagship School – “Construction and reconstruction of brain circuits: Normal and pathological axon guidance“, Aplbach Austria International Society for Neurochemistry, Switzerland
2017	Fellowship Award for ISN Advanced School of Neurochemistry in conjunction with 2017 ISN ESN Meeting, Paris, France International Society for Neurochemistry, Switzerland
2017	Travel award to attend 30th ECNP Congress, Paris, France European College of Neuropsychopharmacology, Netherlands
2016	Travel Award for the ECNP Workshop on Neuropsychopharmacology for Junior Scientists in Europe, March 2016, Nice, France European College of Neuropsychopharmacology (ECNP), Netherlands
2016	Travel Award for the ECNP Annual meeting , September 2016, Vienna, Austria European College of Neuropsychopharmacology (ECNP), Netherlands
2016	Travel Award for 7th ISN Special Conference - “Synaptic Function and Dysfunction in Brain Diseases”, Coimbra, Portugal International Society for Neurochemistry, Switzerland
2016	IBRO/SfN Travel Grant to attend 2016 SfN in San Diego, Califórnia USA International Brain Research Organization, France