???global.info.a_carregar???
Tatiana J. Carneiro's academic career is based in the Biochemistry field. She concluded the BSc degree in 2015 and the MSc degree in Biomolecular Methods in 2017, both at University of Aveiro, with scientific work developed within the scope of metabolomics. In 2018, she worked as a research fellow on the BioIMPACT project (Ref. PTDC/QEQ-MED/1890/2014, funded by FCT), which aimed to evaluate the metabolic impact of new-synthetized complex Palladium(II)-spermine as a potential antineoplastic agent with reduced side-effects compared to the conventional drug cisplatin. From 2019 to 2024, she pursued a PhD in Biochemistry at the University of Aveiro, focusing on identifying biomarkers of the in vitro and in vivo metabolic impact of metal-based drugs, as potential new low-toxic therapeutic agents against triple-negative breast cancer. The work developed during her PhD led to fifteen publications in peer-reviewed journals, with Tatiana J. Carneiro as the first author in nine papers, as well as participation in national and international conferences with fifteen posters and oral presentations. Currently, she is a postdoctoral fellow in the Body Barrier Immunometabolism Laboratory, at UC-Biotech (CIBB/CNC, University of Coimbra). She is involved in the Kinder-GUT project (Ref. HR22-00754, funded by the “La Caixa” Foundation - CaixaResearch Health 2022), which aims to identify new therapeutic targets for gastrointestinal infections by characterizing the molecular patterns of intestinal intraepithelial lymphocytes in the contexts of both intestinal absorption/metabolism and immune response to pathogens.
Read full resume ↓
Identification

Personal identification

Full name
Tatiana João Ribeiro Gonçalves Carneiro

Citation names

  • Carneiro, Tatiana J.

Author identifiers

Ciência ID
0317-113D-94E8
ORCID iD
0000-0003-4841-7860

Email addresses

  • tatiana.carneiro@cnc.uc.pt (Professional)

Telephones

Telephone
  • 231249187 (Professional)

Addresses

  • UC-Biotech, Parque Tecnológico de Cantanhede Núcleo 04, Lote 8, 3060-197, Cantanhede, Coimbra, Portugal (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Biochemistry
  • Exact Sciences - Chemical Sciences
  • Natural sciences - Biological Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
English Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Intermediate (B1)
Spanish; Castilian Elementary (A2) Intermediate (B1) Beginner (A1) Intermediate (B1) Elementary (A2)
Education
Degree Classification
2019/09/01 - 2024/05/15
Concluded
 Biochemistry (Doutoramento)
Universidade de Aveiro CICECO, Portugal

Universidade de Aveiro Departamento de Química, Portugal
"(PT) Biomarcadores metabólicos da eficácia de novos fármacos a utilizar na quimioterapia do cancro da mama: estudo metabolómico - (ING) Metabolic biomarkers of chemotherapeutic efficacy of potential novel drugs in breast cancer: a metabolomics study" (THESIS/DISSERTATION)
 Approved (with distinction and merit)
2017
Concluded
 Biochemistry (Mestrado)
Major in Biomolecular Methods
Universidade de Aveiro, Portugal
"(PT) Impacto metabólico da expressão dos oncogenes KRAS e MYC em murganhos com pancreatite e cancro pancreático - (ING) Metabolic impact of oncogenes KRAS and MYC expression in mice with pancreatitis and pancreatic cancer " (THESIS/DISSERTATION)
 16,850
2016
Concluded
 Biochemistry (Licenciatura)
Universidade de Aveiro, Portugal
"(PT) Metabolómica celular para compreensão do efeito de materiais piezoelétricos na regeneração de tecidos - (ING) Cell metabolomics to assess the effect of piezoelectric materials on tissues regeneration" (THESIS/DISSERTATION)
 12,944
Affiliation

Others

Category
Host institution 		Employer
2024/09/16 - Current Postdoc fellow Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018/05/20 - 2019/07/31 Research fellow Universidade de Aveiro CICECO, Portugal
Universidade de Aveiro CICECO, Portugal
(...)
Projects

Grant

Designation Funders
2024/09/16 - 2025/09/25 Kinder-GUT: Role of diet-derived retinoids in CD8aa intraepithelial lymphocytes and intestinal defence at early-life
HR22-00754
Post-doc Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Ongoing
2018/05/20 - 2019/07/31 BioImpact: Biochemical Impact of Ptatinum and Palladium Anticancer Agent
PTDC/QEQ-MED/1890/2014
Research Fellow
Universidade de Coimbra Unidade de Investigação e Desenvolvimento Química-Física Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference poster
  1. Atella, Sabrina; Carneiro, Tatiana J.; A.L.M., Batista de Carvalho; Vojtek, Martin; Laginha, Raquel C.; Marques, Maria Paula M.; Diniz, Carmen; Gil, Ana M.. "Unravelling the exometabolome signature of cisplatin-resistance in triple-negative breast cancer MDA-MB-231 cells". Paper presented in XXII National Congress of Biochemistry, 2024.
  2. Ferreira, Manuela; Bastos-Amador, Patricia; Silva, Ana Raquel; Raposo, Bruno; Torres, Júlio; Oliveira-Machado, Tomás; Casquinha, Maria; et al. "Retinoid signals in epithelial unconventional T cells: implications for intestinal malignancy control". Paper presented in Champalimaud Research Symposium 2024, 2024.
  3. Carneiro, Tatiana J.; Vojtek, M.; Gonçalves-Monteiro, Salomé; Ana L. M. Batista de Carvalho; Marques, MPM; Diniz, C.; Gil, A.M.. "O Perfil Metabólico de Tumor e Cérebro de Ratinhos Xenógrafos de Cancro da Mama Triplo-Negativo Revela Efeito Promissor do Complexo Pd2Espermina Relativamente a Cisplatina". Paper presented in 5º Encontro Nacional de Jovens Investigadores em Oncologia, 2023.
  4. Carneiro, Tatiana J.; Vojtek, M.; Gonçalves-Monteiro, Salomé; Ana L. M. Batista de Carvalho; Marques, MPM; Diniz, C.; Gil, A.M.. "NMR metabolomics unveils a beneficial metabolic response of mice brain to Palladium(II)-Spermine, a possible alternative to cisplatin for cancer treatment". Paper presented in The 19th European Magnetic Resonance Congress (EUROMAR 2023), 2023.
  5. Carneiro, Tatiana J.; Vojtek, Martin; Gonçalves-Monteiro, Salomé; A.L.M., Batista de Carvalho; Maria Paula Matos Marques; Carmen Diniz; Gil, Ana M.. "In vivo 1H NMR metabolomics: Triple-Negative Breast Cancer response to anticancer drug Pd2(Spermine).". Paper presented in 8th International Iberian Biophysics Congress, 2022.
  6. Carneiro, Tatiana J.. "NMR metabolic profile of the in vivo impact of a potential anticancer drug - Pd2(spermine)". Paper presented in Euromar 2021, 2021.
  7. Carneiro, Tatiana J.. "NMR metabolomics to assess the impact of anticancer drugs Cisplatin and Pd2(spermine) on mice organs". Paper presented in 10th GERMN - 9th Ibero American - 7th Iberian NMR Meeting, 2021.
  8. Carneiro, Tatiana João; Araújo, Rita; Vojtek, Martin; Gonçalves-Monteiro, Salomé; Ana L. M. Batista de Carvalho; Pereira, Carmen; Marques, M.P.M.; Gil, Ana M.. "NMR metabolomics to assess nephrotoxicity induced by cisplatin and Pd2(spermine) in a mouse model". Paper presented in Jornadas CICECO 2019 - Where Science Meets Society, 2019.
  9. Carneiro, Tatiana João; Serrão, Eva; Pinto, Joana; Barros, António S.; Brindle, Kevin; Gil, Ana M.. "Metabolic profiling of pancreatitis and KRAS-induced pancreatic cancer in a mouse model". Paper presented in 6th Portuguese Young Chemists, 2018.
  10. Araújo, Rita; Carneiro, Tatiana J.; Marinho, Paula; Maltez da Costa, Marisa; Roque, Ana; Cruz e Silva, Odete A.B.; Fernandes, Maria Helena; Vilarinho, Paula M.; Gil, Ana M.. "Metabolic adaptation of human osteoblasts to growth on non-poled and poled-PLLA films". Paper presented in 6th Portuguese Young Chemists, 2018.
Journal article
  1. Ferreira, Helena; Duarte, Daniela; Carneiro, Tatiana J.; Costa, Célia; Barbosa, Joana C.; Rodrigues, João E.; Alves, Paulo; et al. "Impact of a legumes diet on the human gut microbiome articulated with fecal and plasma metabolomes: A pilot study". Clinical Nutrition ESPEN 63 (2024): 332-345. http://dx.doi.org/10.1016/j.clnesp.2024.06.051.
    Published • 10.1016/j.clnesp.2024.06.051
  2. Carneiro, Tatiana J.; Batista de Carvalho, Ana L. M.; Vojtek, Martin; Laginha, Raquel C.; Marques, Maria Paula M.; Diniz, Carmen; Gil, Ana M.. "Pd2Spermine as an Alternative Therapeutics for Cisplatin-Resistant Triple-Negative Breast Cancer". Journal of Medicinal Chemistry 67 8 (2024): 6839-6853. http://dx.doi.org/10.1021/acs.jmedchem.4c00435.
    Open access • Published • 10.1021/acs.jmedchem.4c00435
  3. Daniela S. C. Bispo; Marlene Correia; Tatiana J. Carneiro; Ana S. Martins; Aliana A. N. Reis; Ana L. M. Batista de Carvalho; Maria P. M. Marques; Ana M. Gil. "Impact of Conventional and Potential New Metal-Based Drugs on Lipid Metabolism in Osteosarcoma MG-63 Cells". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms242417556.
    10.3390/ijms242417556
  4. Carneiro, Tatiana J.; A.L.M., Batista de Carvalho; Vojtek, Martin; Carmo, Inês F.; Marques, MPM; Diniz, Carmen; Gil, Ana M.. "Disclosing a metabolic signature of cisplatin resistance in MDA-MB-231 triple-negative breast cancer cells by NMR metabolomics". Cancer Cell International 23 1 (2023): http://dx.doi.org/10.1186/s12935-023-03124-0.
    10.1186/s12935-023-03124-0
  5. Tatiana J. Carneiro; Martin Vojtek; Salomé Gonçalves-Monteiro; Ana L. M. Batista de Carvalho; Maria Paula M. Marques; Carmen Diniz; Ana M. Gil. "Effect of Pd2Spermine on Mice Brain-Liver Axis Metabolism Assessed by NMR Metabolomics". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms232213773.
    10.3390/ijms232213773
  6. Carneiro, Tatiana J.; Pinto, Joana; Serrao, Eva M.; Barros, António S.; Brindle, Kevin M.; Gil, Ana M.. "Metabolic profiling of induced acute pancreatitis and pancreatic cancer progression in a mutant Kras mouse model". Frontiers in Molecular Biosciences 9 (2022): http://dx.doi.org/10.3389/fmolb.2022.937865.
    10.3389/fmolb.2022.937865
  7. Carneiro, Tatiana J.; Vojtek, Martin; Gonçalves-Monteiro, Salomé; Neves, João R.; Carvalho, Ana L. M. Batista de; Marques, Maria Paula M.; Diniz, Carmen; Gil, Ana M.. "Metabolic Impact of Anticancer Drugs Pd2Spermine and Cisplatin on the Brain of Healthy Mice". Pharmaceutics 14 2 (2022): 259. http://dx.doi.org/10.3390/pharmaceutics14020259.
    Open access • Published • 10.3390/pharmaceutics14020259
  8. Carneiro, Tatiana J.; Araújo, Rita; Vojtek, Martin; Gonçalves-Monteiro, Salomé; Batista de Carvalho, Ana L. M.; Marques, Maria Paula M.; Diniz, Carmen; Gil, Ana M.. "Impact of the Pd2Spm (Spermine) Complex on the Metabolism of Triple-Negative Breast Cancer Tumors of a Xenograft Mouse Model". International Journal of Molecular Sciences 22 19 (2021): 10775. http://dx.doi.org/10.3390/ijms221910775.
    Open access • Published • 10.3390/ijms221910775
  9. Tatiana J. Carneiro; Rita Araújo; Martin Vojtek; Salomé Gonçalves-Monteiro; Carmen Diniz Ana L. M. Batista de Carvalho; MPM Marques; Ana M. Gil. "Novel Insights into Mice Multi-Organ Metabolism uponExposure to A Potential Anticancer Pd(II)-Agent". Metabolites (2021): https://www.mdpi.com/2218-1989/11/2/114.
    10.3390/metabo11020114
  10. Carneiro, Tatiana J.; Martins, Ana S.; Marques, M. Paula M.; Gil, Ana M.. "Metabolic Aspects of Palladium(II) Potential Anti-Cancer Drugs". Frontiers in Oncology 10 (2020): http://dx.doi.org/10.3389/fonc.2020.590970.
    Open access • Published • 10.3389/fonc.2020.590970
  11. Carneiro, Tatiana J.; Araújo, Rita; Vojtek, Martin; Gonçalves-Monteiro, Salomé; Diniz, Carmen; Batista de Carvalho, Ana L.M.; Marques, Maria Paula M.; Gil, Ana M.. "Multi-Organ NMR Metabolomics to Assess In Vivo Overall Metabolic Impact of Cisplatin in Mice". Metabolites 9 11 (2019): 279. http://dx.doi.org/10.3390/metabo9110279.
    Open access • 10.3390/metabo9110279
  12. Araújo, Rita; Carneiro, Tatiana J.; Marinho, Paula; da Costa, Marisa Maltez; Roque, Ana; da Cruz e Silva, Odete A. B.; Fernandes, Maria Helena; Vilarinho, Paula M.; Gil, Ana M.. "NMR metabolomics to study the metabolic response of human osteoblasts to non-poled and poled poly (L-lactic) acid". Magnetic Resonance in Chemistry 57 11 (2019): 919-933. http://dx.doi.org/10.1002/mrc.4883.
    Open access • Published • 10.1002/mrc.4883
  13. Pereira, Joana L.; Duarte, Daniela; Carneiro, Tatiana J.; Ferreira, Sara; Cunha, Bárbara; Soares, Daniela; Costa, Ana Luísa; Gil, Ana M.. "Saliva NMR metabolomics: Analytical issues in pediatric oral health research". Oral Diseases 25 6 (2019): 1545-1554. http://dx.doi.org/10.1111/odi.13117.
    Open access • Published • 10.1111/odi.13117
  14. Laíns, Inês; Duarte, Daniela; Barros, António S.; Martins, Ana Sofia; Carneiro, Tatiana J.; Gil, João Q.; Miller, John B.; et al. "Urine Nuclear Magnetic Resonance (NMR) Metabolomics in Age-Related Macular Degeneration". Journal of Proteome Research 18 3 (2019): 1278-1288. http://dx.doi.org/10.1021/acs.jproteome.8b00877.
    Open access • Published • 10.1021/acs.jproteome.8b00877
  15. Silva, João C. P.; Mota, Marta; Martins, Fátima O.; Nogueira, Célia; Gonçalves, Teresa; Carneiro, Tatiana; Pinto, Joana; et al. "Intestinal Microbial and Metabolic Profiling of Mice Fed with High-Glucose and High-Fructose Diets". Journal of Proteome Research 17 8 (2018): 2880-2891. http://dx.doi.org/10.1021/acs.jproteome.8b00354.
    Open access • Published • 10.1021/acs.jproteome.8b00354
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/09/24 "Impacto do tratamento com Pd2-Espermina em células MDA-MB-231 resistentes à cisplatina - um estudo de exometabolómica" 6th National Meeting of Young Researchers in Oncology
Portuguese Cancer League (Porto, Portugal)
2023/09/22 "O perfil metabólico de tumor e cérebro de ratinhos xenógrafos de cancro da mama triplo-negativo revela efeito promissor do complexo Pd2Espermina relativamente a cisplatina." 5th National Meeting of Young Researchers in Oncology
Portuguese Cancer League (Porto, Portugal)
2022/07/14 Metabolic response of Triple-Negative Breast Cancer to antineoplastic drug Pd2Spm evaluated by 1H NMR metabolomics. Research Summit 2022
University of Aveiro (Aveiro, Portugal)
2021/07/08 Metabolic profile of the in vivo response to a potential anticancer drug - Pd2(spermine) Research Summit 2021
Universidade de Aveiro (Aveiro, Portugal)
2019/11/15 Nuclear magnetic resonance metabolomics to evaluate the metabolic impact of cisplatin and a potential new anti-cancer drug - palladium(II)-spermine - in a mouse model III International Congress in Health Sciences Research: Towards Innovation and Entrepreneurship - Trends in Aging and Cancer
Centro de Investigação em Ciências da Saúde, Universidade da Beira Interior (Covilhã, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/09/01 - 2024/11/29 Reversal of triple-negative breast cancer (TNBC) resistance to treatment with the drug cisplatin
Co-supervisor of Sabrina Atella Barreira
 MSc degree in Biochemistry (Biomolecular Methods) - Thesis dissertation (Master)
Universidade de Aveiro, Portugal
2020/09/01 - 2021/07/09 Pd2-Spermine (Spm) effect on the lipophilic metabolome of mice brain
Co-supervisor of João R. Neves
 BSc degree Biochemistry - Dissertation of final report (Degree)
Universidade de Aveiro, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2024/09/27 - 2024/09/27 European Researchers' Night 2024 (2024/09/27 - 2024/09/27)
Meeting (Member of the Organising Committee)
 Universidade de Coimbra, Portugal
2024/05/09 - 2024/05/10 4th Meeting of Young Biophysicists, Pybphy & SPBf (2024/05/09 - 2024/05/10)
Meeting (Member of the Organising Committee)
 Sociedade Portuguesa de Bioquímica, Portugal
2023/09/30 - 2023/09/30 European Researchers' Night 2023 (2023/09/30 - 2023/09/30)
Meeting (Member of the Organising Committee)
 Universidade de Aveiro, Portugal
2023/06/01 - 2023/06/02 3rd Meeting of Young Biophysicists, Pybphy & SPBf (2023/06/01 - 2023/06/02) Sociedade Portuguesa de Bioquímica, Portugal
2022/06/03 - 2022/06/03 2nd Meeting of Young Biophysicists, Pybphy & SPBf (2022/06/03 - 2022/06/03)
Meeting (Member of the Organising Committee)
 Sociedade Portuguesa de Bioquímica, Portugal
2022/05/25 - 2022/05/25 AIM Further 2022, CAD-CICECO (2022/05/25 - 2022/05/25)
Meeting (Member of the Organising Committee)
 Universidade de Aveiro CICECO, Portugal
2022/03/30 - 2022/03/30 Making Science (Pretty) Simple, CAD-CICECO (2022/03/30 - 2022/03/30)
Workshop (Member of the Organising Committee)
 Universidade de Aveiro CICECO, Portugal
2022/02/09 - 2022/02/09 LATEX Workshop, CAD-CICECO (2022/02/09 - 2022/02/09)
Workshop (Member of the Organising Committee)
 Universidade de Aveiro CICECO, Portugal
2022/01/24 - 2022/01/24 3D Printing Workshop, CAD-CICECO (2022/01/24 - 2022/01/24)
Workshop (Member of the Organising Committee)
 Universidade de Aveiro CICECO, Portugal
2021/11/29 - 2021/11/29 Welcome event for PhD students, CAD-CICECO (2021/11/29 - 2021/11/29)
Festival (Member of the Organising Committee)
 Universidade de Aveiro CICECO, Portugal
2019/09/11 - 2019/09/11 1st Iberian Seminar on NMR Metabolomics in Clinical Research, University of Aveiro, 11th September 2019 (2019/09/11 - 2019/09/11)
Seminar (Member of the Organising Committee)
 Universidade de Aveiro CICECO, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023/06/18 - 2023/06/23 XV "Manuel Rico" NMR Summer School
Other
 XV "Manuel Rico" NMR Summer School
Real Sociedad Espanola de Quimica, Spain
2020/09/24 - 2020/11/24 HiTech Two – training program of skills in technology, commercialization and entrepreneurship by HiSeedTech - Association for Knowledge Valorisation
Other
 HiTech Two – training program of skills in technology, commercialization and entrepreneurship
Universidade do Porto Porto Business School, Portugal
2020/09/07 - 2020/09/18 Advanced Course in Laboratory Animal Science – FELASA accredited; Functions: A,B and D; Species mice, rat, zebra fish and fish
Other
 Advanced Course in Laboratory Animal Science – FELASA accredited
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2020/06/02 - 2020/07/21 HiTech One – training program of skills in technology, commercialization and entrepreneurship by HiSeedTech - Association for Knowledge Valorisation
Other
 HiTech One – training program of skills in technology, commercialization and entrepreneurship
Universidade do Porto Porto Business School, Portugal
2020/06 - 2020/06 Advanced Course in Lipidomics
Seminar
 Advanced Course in Lipidomics
Universidade de Aveiro, Portugal
2019/12 - 2019/12 Advanced Course in Glycomics
Seminar
 Advanced Course in Glycomics
Universidade de Aveiro, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024/07/17 "Unlocking Triple-Negative Breast Cancer Resistance in 3D Models" - BSc report in Biochemistry
(Thesis) Main arguer
 Beatriz Moreira (Other)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Faculdade de Ciências, Portugal

Committee member

Activity description
Role 		Institution / Organization
2021/09/01 - 2024/09/01 Portuguese Young Biophysicists group in association with both Portuguese Biophysics Society and Portuguese Biochemical Society
Member
 Sociedade Portuguesa de Bioquímica, Portugal
2021/09/01 - 2022/10/01 Committee of PhD students, CAD-CICECO
Member
 Universidade de Aveiro CICECO, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2021/04/14 - 2023/04/19 XII, XIII and XIV editions of Biochemistry Day
Evaluator
 Universidade de Aveiro Departamento de Química, Portugal

Mentoring / Tutoring

Topic Student name
2022/12/13 - 2023/09/01 Metabolic signature of cisplatin resistance in MDA-MB-231 triple-negative breast cancer cells Inês F. Carmo, BSc
2020/09/01 - 2022/08/01 Metabolic impact of legumes diet on the human gut Helena Ferreira, PhD
2018/09/01 - 2020/02/01 NMR analysis of saliva to aid pediatric oral health research Joana L. Pereira, PhD
2015/09/01 - 2016/09/01 Metabolic response of human osteoblasts to non-poled and poled poly (L-lactic) acid Marisa Maltez-Costa, PhD
Distinctions

Award

2023 Grant to attend the XV "Manuel Rico" NMR Summer School
Real Sociedad Espanola de Quimica, Spain
2022 Grant to attend the 8th International Iberian Biophysics Congress
Sociedade Portuguesa de Bioquímica, Portugal
2019 Grant to attend the III International Congress in Health Sciences Research: Towards Innovation and Entrepreneurship - Trends in Aging and Cancer
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal