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Paulo Nuno Centeio Matafome holds a PhD in Biomedical Sciences since 2012 (Faculty of Medicine, University of Coimbra). He is an Auxiliary Professor of Physiology at the Polytechnic University of Coimbra and an integrated member of the Coimbra Institute of Clinical and Biomedical Research (iCBR), Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra. He has published 103 research articles (9 as the first author and 25 as the main author) and 4 book chapters (>2400 citations, h factor=28). He has supervised or co-supervised 12 PhD students (5 concluded), 22 MSc students (20 concluded), and 21 BSc Students. He has participated in 20 Research Projects (3 as principal Investigator, 1 as Co-Principal Investigator and 15 as Team Member). Paulo is the co-coordinator of the Horizon Europe PAS GRAS project. He is a Deputy Editor-in-chief of the journal Diabetology. Paulo Matafome has collaborations with several Departments of the Local Health Unit of Coimbra for the recruitment of patients and blood and adipose tissue collection. He also collaborates with Brazilian, Spanish and Portuguese groups in the metabolic programming field. Paulo collaborates with the Institute of Health-Applied Nuclear Sciences, to develop new early imaging biomarkers for metabolic diseases and their complications. Moreover, he has been particularly active in studying the neuroendocrine mechanism controlling the gut-adipose tissue crosstalk as a promising therapeutic strategy to prevent obesity, adipose tissue dysfunction and its consequences. He has access to human blood and adipose tissue samples, state-of-the-art bioimaging methods (human and animal PET and MRI), animal models of diabetes (Goto-Kakizaki colony) and his lab has developed methods to evaluate angiogenesis and adipose tissue blood flow ex vivo and in vivo.
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Identification

Personal identification

Full name
Paulo Nuno Centeio Matafome

Citation names

  • Matafome, Paulo

Author identifiers

Ciência ID
0413-7328-BD68
ORCID iD
0000-0002-3422-290X

Email addresses

  • paulo.matafome@uc.pt (Professional)
  • paulo.matafome@estesc.ipc.pt (Professional)

Websites

Education
Degree Classification
2012/12/21
Concluded
 Ciências Biomédicas (Doutoramento)
Major in Sem especialidade
Universidade de Coimbra Faculdade de Medicina, Portugal
"Um novo mecanismo para a desregulação da resposta celular à hipoxia. Implicações para a disfunção celular na diabetes tipo 2." (THESIS/DISSERTATION)
2008/01/20
Concluded
 Biologia Celular (Mestrado)
Universidade de Coimbra Faculdade de Direito, Portugal
2005/06/30
Concluded
 Biologia (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
Affiliation

Science

Category
Host institution 		Employer
2018/12/27 - 2023/08/31 Contracted Researcher (Research) Universidade de Coimbra, Portugal
Universidade de Coimbra Faculdade de Medicina, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2024/09/09 - Current Adjunct Teacher (Polytechnic Teacher) Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal
2010/09 - 2023/07/31 Invited Adjunct Teacher (Polytechnic Teacher) Instituto Politécnico de Coimbra, Portugal
Projects

Grant

Designation Funders
2023/03/01 - Current De-risking metabolic, environmental and behavioral determinants of obesity in children, adolescents and young adults
HORIZON-HLTH-2022-STAYHLTH- 101080329
Universidade de Coimbra, Portugal

Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
European Commission
Ongoing

Contract

Designation Funders
2023/09/01 - Current PAS GRAS - DE-RISKING METABOLIC, ENVIRONMENTAL AND BEHAVIORAL DETERMINANTS OF OBESITY IN CHILDREN, ADOLESCENTS AND YOUNG ADULTS
101080329
Co-Principal Investigator (Co-PI)
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
 Horizon 2020
2021/01/01 - 2025/12/31 Center for Innovative Biomedicine and Biotechnology - Associate Laboratory
LA/P/0058/2020
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2023/03/01 - 2024/08/31 Novas abordagens terapêuticas para a obesidade baseadas na sinalização dopaminérgica periférica
10.54499/2022.05822.PTDC
Universidade de Coimbra, Portugal

Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2023/03/01 - 2024/07/31 THINNER - New THerapeutIc strategies for obesity based oN peripheral dopamiNERgic signalling
2022.05822.PTDC
Principal investigator
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2022/09 - 2024/07 MitoBOOST 2.0 - Prova de Conceito 01/SAICT/2021
01/SAICT/2021
 Comissão de Coordenação e Desenvolvimento Regional do Centro
2019/12/01 - 2023/11/30 Dieta Mediterrânica Enriquecida para combater a Obesidade dos Jovens
PRIMA/0004/2018
10.54499/PRIMA/0004/2018
Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2019/10 - 2022/09 Mediterranean Enriched Diet for tackling Youth Obesity
MED4Youth
Researcher
Partnership for Research and Innovation in the Mediterranean Area
2018/07/26 - 2022/07/25 Modelação de Angiogénese na Diabetes Mellitus Tipo 2 - integrando abordagens experimentais e teóricas
PTDC/BIA-CEL/31743/2017
Universidade de Coimbra, Portugal

Instituto Nacional de Engenharia Biomédica, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2019/01 - 2021/12 AngioDia: Modeling Angiogenesis in Type 2 Diabetes Mellitus - integrating experimental and theoretical approaches
POCI-01-0145-FEDER-031743
Researcher
Fundação para a Ciência e a Tecnologia
2019/11 - 2021/10 Integrating multimodal imaging with metabolomics and oxidative stress outcomes in diabetes
EFSD/Sanofi
Co-Principal Investigator (Co-PI)
European Foundation for the Study of Diabetes
Ongoing
2018/10/01 - 2020/04/30 Protocol of Technical cooperation with SUMOL+COMPAL SA
SUMOL+COMPAL SA
Principal investigator
Universidade de Coimbra, Portugal
 SUMOL+COMAPL Marcas SA
Ongoing
2019/01/01 - 2019/12/31 CNC. IBILI
UID/NEU/04539/2019
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal

Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2016/07/01 - 2019/12/31 Crosstalk between perivascular adipose tissue and blood vessels in obesity and vascular dysfunction
PTDC/BIM-MET/4447/2014
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2016/01/01 - 2019/12/30 Crosstalk entre o tecido adiposo perivascular e os vasos sanguíneos na obesidade e diabetes tipo 2
P2020-PTDC/BIM-MET/4447/2014
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2017/09/01 - 2019/04/30 Identificação de novos biomarcadores precoces das complicações diabéticas: do metabolismo à imagiologia multimodal de sistemas
DiaMarkData: FIS-FIS-2015-01-DIA-20150630-173
Researcher
Infarmed Autoridade Nacional do Medicamento e Produtos de Saúde IP
Concluded
2017/01/01 - 2018/12/31 New targets and biomarkers of positron emission tomography in type 2 diabetes: peripheral dopamine as a modulator of insulin sensitivity in adipose tissue
Bolsa Charneco da Costa 2016
Principal investigator
Sociedade Portuguesa de Diabetologia
Concluded
2015/01/01 - 2017/12/30 Pathways of adipose tissue dysfunction: a route for obesity- related cancer
P2020-PTDC/BIM-MET/4447/2014
 Fundação para a Ciência e a Tecnologia
Concluded
2012/04/01 - 2015/09/30 Vias de disfunção do tecido adiposo: um novo mecanismo para o cancro associado à obesidade
PTDC/SAU-MET/121133/2010
Universidade de Coimbra, Portugal

Universidade de Coimbra Faculdade de Medicina, Portugal

Centro Hospitalar e Universitário de Coimbra EPE, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2012/04 - 2015/06 Unravelling the molecular events of gap junction remodelling in ischemic heart
grant.Provided by PTCRIS: 119296
PTDC/SAU-ORG/119296/2010
Researcher
Fundação para a Ciência e a Tecnologia
2011/03 - 2014/08 Angiogenesis in Diabetic Retinopathy: Integrating Experiments and Modelling
grant.Provided by PTCRIS: 110354
PTDC/SAU-ENB/110354/2009
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2011/02 - 2014/07 New therapeutic approaches for the treatment of vascular complications in type 2 diabetes and metabolic syndrome
grant.Provided by PTCRIS: 115635
PTDC/SAU-MET/115635/2009
PhD Student Fellow
Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2012/12/31 Projecto Estratégico - UI 3282 - 2011-2012
PEst-C/SAU/UI3282/2011
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2007/09 - 2010/12 Disturbance of the physiologic pathways and molecular mechanisms regulating energy homeostasis in obesity and metabolic syndrome: searching new strategies and therapeutic targets
Provided by PTCRIS: 72443
PTDC/SAU-OSM/72443/2006
Other
Fundação para a Ciência e a Tecnologia
2005/09 - 2007/12 What HIF? Degradation is better than growth in preventing angiogenesis in diabetic retinopathy
grant.Provided by PTCRIS: 57772
FCT - POCI/SAU-OBS/57772/2004
Research Technician Fellow
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book
  1. Matafome, P.; Seiça, R.. The role of brain in energy balance. 2017.
    10.1007/978-3-319-63260-5_2
  2. Matafome, P.; Seiça, R.. Function and dysfunction of adipose tissue. 2017.
    10.1007/978-3-319-63260-5_1
  3. Matafome, P.; Eickhoff, H.; Letra, L.; Seiça, R.. Neuroendocrinology of adipose tissue and gut–brain axis. 2017.
    10.1007/978-3-319-63260-5_3
Book chapter
  1. Grilo, Luís F.; Tavares, Renata S.; Gomes, rodrigo mello; Ramalho-Santos, João; Ozanne, Susan; Matafome, Paulo. "Chapter 16. PROGRAMMING OF EARLY AGEING". In Aging - From Fundamental Biology to Societal Impact, edited by Oliveira, Paulo J; Malva, João. Elsevier, 2022.
    Accepted
  2. Susana P. Pereira; Grilo, Luís F.; Tavares, Renata S.; Rodrigo Mello Gomes; Ramalho-Santos, João; Susan E. Ozanne; Matafome, Paulo. "Programming Of Early Ageing.". In Aging - From Fundamental Biology to Societal Impact. 2022.
    Published
Conference abstract
  1. Carina C. Magalhães; Amorim, Ricardo; Ana I. Duarte; Adriana Marques-Carvalho; Susana P. Pereira; Grilo, Luís F.; Mena, Débora; et al. "The mitochondriotropic antioxidant AntiOxBEN2 prevents hepatic steatosis in male and female mice fed with high-fat high-sugar (HFHS) diet". Paper presented in 58th Annual Meeting of the European Society for Clinical Investigation, Barcelona, 2024.
    Accepted
  2. Magalhães, Carina; Amorim, Ricardo; Duarte, Ana; Adriana Marques-Carvalho; Susana P. Pereira; Grilo, Luís F.; Mena, Débora; et al. "O impacto do antioxidante mitocondriotrópico AntiOxBEN2 na esteatose hepática de ratinhos no contexto de Fígado Gordo Não-Alcoólico". Paper presented in 20º Congresso Português de Diabetes, 2024.
  3. Rocha, Sónia; AMARO, ANDREIA; Marcos D. Ferreira-Junior; Proença, Carina; Silva, Artur M. S.; Vera M. Costa; Sara Oliveira; et al. "A hydroxylated flavonoid reduces oxidative stress in an animal model of type 2 diabetes mellitus". 2024.
    Submitted
  4. Sousa, Diana; AMARO, ANDREIA; Mariana Rocha; Ferreira Junior, Marcos Divino; Barra, Cátia; Mello-Gomes, Rodrigo; Matafome, Paulo. "The dysregulation of energy balance crosstalk between the hypothalamus and the brown adipose tissue in overfed rats exposed to maternal glycation". Paper presented in 59 th EASD Annual Meeting of the European Association for the Study of Diabetes, Hamburg, 2023.
    Published
  5. AMARO, ANDREIA; Sousa, Diana; Mariana Rocha; Ferreira Junior, Marcos Divino; Saavedra, Lucas Paulo Jacinto; Barra, Cátia; Baptista, Filipa I.; Matafome, Paulo. "Postnatal overfeeding triggers sex-specific neurodevelopmental delay and induces anxious-like behaviour accompanied by brain-region-specific synaptic imbalance". Paper presented in 59 th EASD Annual Meeting of the European Association for the Study of Diabetes, Hamburg, 2023.
    Published
  6. Sousa, Diana; Amaro, A; Ferreira Junior, Marcos Divino; Pereira, Susana P.; Mariana Rocha; Barra, Cátia; Mello-Gomes, Rodrigo; J Paulo Oliveira; Matafome, Paulo. "Sexual dimorphism in the modulation of energy balance in adipose tissue induced by exposure to obesogenic environments". Paper presented in 57th Annual Scientific Meeting of the European Society for Clinical Investigation, Prague, 2023.
    Published
  7. Amaro, A; Mariana Rocha; Sousa, Diana; Ferreira Junior, Marcos Divino; Saavedra, Lucas Paulo Jacinto; Mello-Gomes, Rodrigo; Baptista, Filipa I.; Matafome, Paulo. "Postnatal overweight- induced offspring neurodevelopment and behaviour alterations associated with synaptic imbalance, according to sex-specific vulnerabilities". Paper presented in 57th Annual Scientific Meeting of the European Society for Clinical Investigation, Prague, 2023.
    Published
  8. Canário, Nádia; Crisóstomo, Joana; Duarte, João V; Duarte, Isabel Catarina; Moreno, Carolina; Ribeiro, Mário; Oliveira, Francisco; et al. "Impaired brain responses in hippocampus and memory circuit in type 2 diabetes without cognitive impairment". Paper presented in IV Congresso Internacional do Centro de Investigação em Neuropsicologia e Intervenção Cognitivo Comportamental - CINEICC 2023, Coimbra, 2023.
    Accepted
  9. Lopes, Eduardo; Rosendo-Silva, Daniela; Matafome, Paulo. Corresponding author: Lopes, Eduardo. "Peripherical crosstalk between Dopamine, Neuropeptide Y and Melanocortin systems". Paper presented in 57th Annual Scientific Meeting of the European Society for Clinical Investigation, Prague, 2023.
    Published
  10. Amaro, A; Rocha, Mariana; Sousa, Diana; Ferreira Junior, Marcos Divino; Barra, Cátia; Monteiro-Alfredo, Tamaeh; Mello-Gomes, Rodrigo; et al. "Neurometabolic and behavioural alterations in the adolescent offspring upon maternal glycation". Paper presented in 58th European Association for the Study of Diabetes Annual Meeting, Stockholm, 2022.
    Published
  11. Sousa, Diana; Amaro, A; Ferreira Junior, Marcos Divino; Susana P. Pereira; Rocha, Mariana; Barra, Cátia; Mello-Gomes, Rodrigo; Oliveira, Paulo; Matafome, Paulo. "Exposure to obesogenic environments during perinatal development modulates offspring nutrient sensing pathways in adipose tissue.". Paper presented in 56th Annual Scientific Meeting of the European Society for Clinical Investigation, Bari, 2022.
    Published
  12. Rosendo-Silva, Daniela; Eickhoff H; Gomes, P.; Pires, A. S.; Abrantes, Ana Margarida; Botelho, Maria Filomena; Seiça, R; Matafome, Paulo. "Alterações do sistema grelina/NPY do tecido adiposo como alvo terapêutico na diabetes tipo 2". Paper presented in 17º Congresso Português de Diabetes, 2021.
  13. Monteiro-Alfredo, Tamaeh; Oliveira, Sara; Antunes, Kátia; dos Santos, Jéssica; Aquino, Diana; Magalhães, Mariana; Cabral, Célia; et al. "FOLHAS DE ACROCOMIA ACULEATA (JACQ.) LODD EX MART. AUMENTAM AS DEFESAS ANTIOXIDANTES E MELHORAM O PERFIL METABÓLICO EM RATOS DIABÉTICOS TIPO 2". Paper presented in 16º Congresso Português de Diabetes, Vilamoura, 2020.
    10.5151/chemeng-cobeq2014-0222-26465-171722
  14. Sacramento, Joana F.; Melo, Bernardete F.; Olea, Elena; Obeso, Ana; Rocher, Asuncion; Rodrigues, Tiago; Prieto-Lloret, Jesus; et al. "Hyperinsulinemia due to altered insulin secretion contributes to insulin resistance in chronic intermittent hypoxia independently of obesity". Paper presented in European-Respiratory-Society (ERS) International Congress, Madrid, 2019.
    Published • 10.1183/13993003.congress-2019.oa4935
  15. Tavares, Gabriela ; Marques, D.; Barra, Cátia; Costa, A.; Rodrigues, T.; Joana F. Sacramento; Melo, Bernardete F.; et al. "P102-F - Bromocriptine decreases hepatic steatosis by modulation of the dopamine signaling in liver". Paper presented in Special Issue: Abstracts of the 53rd Annual Scientific Meeting of the European Society for Clinical Investigation ¿The Clocks of Metabolism and Disease, Coimbra, 2019.
    doi.org/10.1111/eci.13109
  16. Ferreira AS; Galvão S; Ventura I; Gaspar R; Rodrigues-Neves AC; Matafome, Paulo; Fontes-Ribeiro CA; et al. "Antenatal glucocorticoid impact in peripheral metabolism: gender-specific alterations in glycemia levels". 2019.
  17. Monteiro-Alfredo, Tamaeh; Oliveira, Sara; dos Santos, Jéssica Maurino; Antunes, Kátia Ávila; da Cunha, Janielle da Silva Melo; de Castro, David Tsuyoshi Hiramatsu; Oliveira, Alex Santos; et al. "Determination of the antioxidant potential of the leaves of Acrocomia aculeata (Jacq.) Lodd. ex Mart.". Paper presented in 53th Annual Scientific Meeting of the European Society for Clinical Investigation, Coimbra, 2019.
    Published
  18. Letra, Liliana; Matafome, Paulo; Rodrigues, Tiago; Duro, Diana; Baldeiras, Inês; Patrício, Miguel; Sena, Cristina; Seiça, Raquel. "Adiponectina Pode Atrasar A Progressão De Defeito Cognitivo Ligeiro Para Demência De Alzheimer". Paper presented in 14º Congresso Português de Diabetes, Vilamoura, 2018.
    Published
  19. Marques, IA; Abrantes, Margarida; Neves, AR; Pires, AS; Costa, G; Caramelo, F; Matafome, Paulo; et al. "Radium-223 and metastatic prostate cancer: new insights from cellular studies". Paper presented in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2017.
    Published
  20. Letra, Liliana; Rodrigues, Tiago; Matafome, Paulo; Duro, Diana; Lemos, Raquel; Patricio, Miguel; Castelo-Branco, Miguel; et al. "Elevated serum adiponectin in Alzheimer's disease as neuroprotective strategy". Paper presented in 19th European Congress of Endocrinology, Lisboa, 2017.
    Published • 10.1530/endoabs.49.ep704
  21. Letra, Liliana; Matafome, Paulo; Rodrigues, Tiago; Almeida, André; Patrício, Miguel; Duro, Diana; Lemos, Raquel; et al. "Níveis elevados de adiponectina sérica em doentes com Demência de Alzheimer como possível estratégia sensibilizadora de insulina no hipocampo". Paper presented in 13º Congresso Português de Diabetes, Albufeira, 2017.
    Published
  22. Letra, Liliana; Lemos, Raquel; Duro, Diana; Matafome, Paulo; Silva, D; Seiça, Ricardo; Santana, Isabel. "Relação entre as adipocinas séricas e biomarcadores de doença de Alzheimer". Paper presented in 29ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência, Aveiro, 2015.
    Published
  23. Matafome, Paulo; Rodrigues, Tiago; Pereira, Ana; Paixão, Ana; Silvério, Mário; Boukari, Adem; Ayari, Sami; et al. "A administração de adiponectina através de uma bomba infusora diminui a intolerância à glicose e melhora o metabolismo do tecido adiposo em ratos mantidos com dieta rica em gorduras". Paper presented in 11º Congresso Português de Diabetes, Vilamoura, 2014.
    Published
  24. Matafome, Paulo; Rodrigues, Tiago; Silvério, Mário; Paixão, Ana; Boukari, Adem; Ayari, Sami; Letra, Liliana; et al. "Exogenous adiponectin administered through a minipump reverts high-fat diet-induced impairment of adipose tissue metabolism in wistar rats". Paper presented in XXXV Congresso Português de Cardiologia, Albufeira, 2014.
    Published
  25. Letra, Liliana; Santos-Silva, Daniela; Matafome, Paulo; Crisóstomo, Joana; Gonçalves, Ana Cristina; Sarmento-Ribeiro, Ana B.; Seiça, Raquel; Pereira, Maria Amélia. "Obesity-related colon cancer: the role of dysfunctional adipose tissue". Paper presented in 10º Congresso Português de Diabetes, Vilamoura, 2012.
    Published
Conference paper
  1. Martins-Marques, Tânia; Marques, Carla; Ribeiro-Rodrigues, Teresa; Matafome, Paulo; Pereira, Paulo; Gonçalves, Lino; Girão, Henrique. "To beat or not to beat: detrimental autophagy contributes to gap junctions degradation in ischemic heart". Paper presented in European Heart Journal: ESC Congress, 2013.
    Published
  2. Ribeiro-Rodrigues, Teresa; Marques, Carla; Martins-Marques, Tânia; Matafome, Paulo; Pereira, Paulo; Gonçalves, Lino; Girão, Henrique. "Ubiquitin induces interference in communication: ubiquitination of cx43 leads to gap junction degradation in ischemic heart". Paper presented in European Heart Journal: ESC Congress, 2013.
    Published
  3. Marques, Carla; Matafome, Paulo; Santos, Ana Rita; Lobo, Conceição; Shang, Fu; Pereira, Paulo; Girao, Henrique. "In vivo analysis of protein quality control in response to aging using transgenic mice". Paper presented in Acta Ophthalmologica, 2013.
    Published
Conference poster
  1. Oliveira, Sara; Campos, Elisa J.; Fernandes, Rosa; Rui C Bernardes; Matafome, Paulo; António Francisco Ambrósio. "Sex-related differences in the visual function of an animal model of type 1 diabetes". Paper presented in 26th EVER Congress, 2023.
  2. Adelaide Sousa; Rui Azevedo; Costa, Vera M; Sara Oliveira; Inês Preguiça; Sofia Viana; Flávio Reis; et al. "Impact of dietary exposure to silver nanoparticles on the intestinal inflammatory response in C57BL/6J mice". Paper presented in 12th International Symposium on Biological Monitoring in Occupational and Environmental Health, 2023.
  3. Canário, Nádia; Joana Crisóstomo; João Valente Duarte; Duarte, Isabel Catarina ; Carolina Moreno; Ribeiro, Mário; Beatriz Caramelo; et al. "Alterações na resposta cerebral no hipocampo e circuitos de memória na diabetes tipo 2 sem comprometimento cognitivo". Paper presented in 19º Congresso português na diabetes, 2023.
  4. Duarte-Araújo, Margarida; Esteves-Monteiro, Marisa; Ferreira-Duarte, Mariana; Matafome, Paulo; Sara Oliveira; Morato, Manuela; Dias-Pereira, Patrícia. "Alterações histomorfométricas do intestino de um modelo animal de diabetes tipo 2: ratazanas Goto-Kakizaki.". Paper presented in 19º Congresso Português de Diabetes, Sociedade Portuguesa de Diabetologia, 2023.
  5. Esteves-Monteiro, Marisa; Ferreira-Duarte, Mariana; Dias-Pereira, Patrícia; Matafome, Paulo; Morato, Manuela; Duarte-Araújo, Margarida. "Intestinal histomorphometry of Goto-Kakizaki type 2 diabetic rats". Paper presented in International Diabetes Federation (IDF) World Diabetes Congress 2022, 2022.
  6. José Ponce-de-Leão; Fátima O. Martins; Rosendo-Silva, Daniela; Melo, Bernardete F.; Farreca, Solange; Adriana M. Capucho; Joana F. Sacramento; Matafome, Paulo; Conde, Silvia V. "Chronic caffeine intake ameliorates white adipose tissue adenosine signaling and its metabolism alterations in dysmetabolic states José". Paper presented in 2º Congresso Internacional de Fisiologia SPFis - 2022, 2022.
  7. Esteves-Monteiro, Marisa; Ferreira-Duarte, Mariana; Dias-Pereira, Patrícia; Matafome, Paulo; Morato, Manuela; Duarte-Araújo, Margarida. "Histomorphometric ex vivo changes in the ileum and colon of type 1 and type 2 diabetes mellitus animal models". Paper presented in XVIII Congresso Internacional Veterinário Montenegro, 2022.
  8. Oliveira, Sara; Monteiro-Alfredo, Tamaeh; Henriques, Rita; Fontes Ribeiro, Carlos; Seiça, Raquel; Cabral, Célia; Cruz, Teresa; et al. "Desenvolvimento de um derivado da curcumina com propriedades hipoglicémicas: Impacto no stress oxidativo e na função endotelial na Diabetes tipo 2". Paper presented in 16º Congresso Português de Diabetes, 2020.
  9. Joana F. Sacramento; Melo, Bernardete F.; Olea, Elena; Obeso, Ana; Rocher A; Rodrigues, T.; Prieto-Lloret, Jesus; et al. "A hiperinsulinémia contribui para o desenvolvimento da resistência à insulina na apneia obstrutiva do sono independentemente da obesidade.". Paper presented in 16th Portuguese Congress of Diabetes, 2020.
  10. Marques, I.A.; Abrantes, Ana Margarida; Pires, A.S.; Neves, A.R.; Tavares, N.; Caramelo, Francisco; Tavares-da-Silva, Edgar; et al. "The radiobiological effects of Radium-223 in metastatic prostate cancer cells". Paper presented in ESUR19 ¿ 26th Meeting of the EAU Section of Urological Research, 2019.
  11. Oliveira, Sara; Monteiro-Alfredo, Tamaeh; Henriques, Rita; Asperçada, Luís; Fontes Ribeiro, Carlos; Seiça, Raquel; Cruz, Teresa; et al. "Development of a curcumin derivative with hypoglycemic proprieties: impact on oxidative stress and endothelial function in type 2 Diabetes". Paper presented in Envelhecimento: modelos, mecanismos e terapias, 2019.
  12. das Neves Borges, Patricia; Rodrigues, T; Matafome, Paulo; Seica, Raquel. "Treatment with osteocalcin, an osteoblast-secreted hormone, ameliorates insulin resistance and adipose tissue function in a lean model of T2D". Paper presented in 53rd Annual Scientific Meeting of the European Society for Clinical Investigation ¿The Clocks of Metabolism and Disease¿, 2019.
  13. Tavares, Gabriela; Marques, Daniela; Barra, Cátia; Reis-Costa, Ana; Tiago Rodrigues; Joana F. Sacramento; Melo, Bernardete F.; et al. "Modulation of dopaminergic signalling with Bromocriptine improves glucose and lipid metabolism in white and brown adipose tissue in a type 2 diabetic obese animal model". Paper presented in 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI), 2019.
  14. Barra, Cátia; Costa, A.; Tavares, Gabriela ; Marques, D.; Rodrigues, T.; Joana F. Sacramento; Melo, Bernardete F.; et al. "Bromocriptine decreases hepatic steatosis by modulation of the dopamine signaling in liver.". Paper presented in 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI), 2019.
  15. Barra, Cátia; Costa, A.; Tavares, Gabriela ; Marques, D.; Rodrigues, T.; Joana F. Sacramento; Melo, Bernardete F.; et al. "A bromocriptina reduz a esteatose hepática por modulação da sinalização dopaminérgica no fígado.". Paper presented in 15th Portuguese Congress of Diabetes, 2019.
  16. Joana F. Sacramento; Marques, D.; Costa, A.; Barra, Cátia; Santos AS.; Rodrigues, T.; Joana F. Sacramento; et al. "A bromocriptina na diabetes tipo 2: alterações da sensibilidade à insulina no fígado e no tecido adiposo.". Paper presented in 14th Portuguese Congress of Diabetes, 2018.
  17. Joana F. Sacramento; Ribeiro, MJ.; Rodrigues, T.; Matafome, Paulo; Guarino, Maria Pedro; Seiça, R.; Silvia V. Conde. "A2 adenosine receptors mediate chronic caffeine effects on insulin sensitivity.". Paper presented in 53rd Annual Meeting of the European Association for the Study of Diabetes, 2017.
  18. Martins IB.; Ribeiro, MJ.; Melo, Bernardete F.; Rodrigues, T.; Joana F. Sacramento; Seiça, R.; Matafome, Paulo; Silvia V. Conde. "Alterations in adenosine metabolism and adenosine receptor expression are associated with insulin resistance.". Paper presented in 53rd Annual Meeting of the European Association for the Study of Diabetes, 2017.
  19. Matafome, Paulo; Marques, D.; Santos AS.; Rodrigues, T.; Joana F. Sacramento; Melo, Bernardete F.; Seiça, R.; Silvia V. Conde. "Bromocriptine changes adipocyte lipid metabolismo improving insulin sensitivity in obese diabetic rats.". Paper presented in 53rd Annual Meeting of the European Association for the Study of Diabetes., 2017.
  20. Marques, D.; Santos AS.; Neves I.; Rodrigues, T.; Joana F. Sacramento; Melo, Bernardete F.; Sereno J.; et al. "A bromocriptina melhora a sensibilidade á insulina, sistémica e do tecido adiposo, por modulação da sinalização dopaminérgica.". Paper presented in 13rd Portuguese Congress of Diabetes, 2017.
  21. Marques, Carla; Baptista, Rui ; Matafome, Paulo; Zuzarte, Mónica; Castro, Graça; Pereira, Paulo; Enguita, Francisco J.. "The significance in Pulmonary Arterial Hypertension of miR-424". Paper presented in 3rd PROTEOSTASIS Action Meeting: PROTEOSTASIS and its Biological Implications, 2017.
  22. Marques, Carla; Baptista, Rui ; Matafome, Paulo; Zuzarte, Mónica; Enguita, Francisco J.; Girão, Henrique. "miR-424 and SMURF1: the significance in Pulmonary Arterial Hypertension". Paper presented in Pt Beat, 2017.
  23. Martins IB.; Ribeiro, MJ.; Melo, Bernardete F.; Rodrigues, T.; Joana F. Sacramento; Seiça, R.; Matafome, Paulo; Silvia V. Conde. "Is adenosine an important mediator in insulin sensitivity?". Paper presented in iMed Conference® 9.0, 2017.
  24. Joana F. Sacramento; Melo, Bernardete F.; Rodrigues, T.; Coelho, JC.; Olea, Elena; Ribeiro MJ.; Guarino, MP; et al. "Carotid body transection restores glucose and lipid homeostasis in prediabetes animal models.". Paper presented in 52nd Annual Meeting of the European Association for the Study of Diabetes, 2016.
  25. Ribeiro MJ.; Joana F. Sacramento; Rodrigues, T.; Matafome, Paulo; Diogo LN,; Seiça RM; Guarino, MP; Silvia V. Conde. "Unraveling the molecular mechanisms involved in chronic intermittent hypoxia-induced insulin resistance.". Paper presented in 51st Annual Meeting of the European Association for the Study of Diabetes, 2015.
  26. Coelho, JC.; Melo, Bernardete F.; Rodrigues, T.; Matafome, Paulo; Joana F. Sacramento; Ribeiro, MJ.; Guarino, MP; Seiça, R.; Silvia V. Conde. "Chronic caffeine intake restores insulin sensitivity in high-sucrose diet rats through adaptations in adipose tissue metabolism.". Paper presented in 51st Annual Meeting of the European Association for the Study of Diabetes, 2015.
  27. Joana F. Sacramento; Matafome, Paulo; Rodrigues, T.; Ribeiro, MJ.; Diogo, LN.; Seiça RM.; Monteiro, EC.; Silvia V. Conde. "Alterations in adipose tissue metabolism and signaling contribute to insulin resistance induced by chronic intermittent hypoxia.". Paper presented in VI Annual Meeting of IBILI (Institute for Biomedical Imaging and Life Sciences), 2014.
  28. Marques, Carla; Matafome, Paulo; Santos, Ana Rita; Lobo, Conceição; Shang, Fu; Girao, Henrique. "Quality Control and Ubiquitin Proteasome System: Implications on Cataract.". Paper presented in European Association for Vision and Eye Research (EVER), 2013.
  29. Jorge, Elisabete; Monteiro, Silvia; Saraiva, Fatima; Baptista, Rui; Matafome, Paulo; Louro, Teresa; Monteiro, Pedro; et al. "Inflammation, Diabetes, and Metabolism Post Acute Coronary Syndromes: Optimal Management will Get a Fair Result". Paper presented in World Congress of Cardiology 2010, 2010.
Journal article
  1. Rosendo-Silva, Daniela; Lopes, Eduardo; Monteiro-Alfredo, Tamaeh; Falcão-Pires, Inês; Eickhoff, Hans; Viana, Sofia; Reis, Flávio; et al. "The adipose tissue melanocortin 3 receptor is targeted by ghrelin and leptin and may be a therapeutic target in obesity". Molecular and Cellular Endocrinology 594 (2024): 112367. http://dx.doi.org/10.1016/j.mce.2024.112367.
    10.1016/j.mce.2024.112367
  2. Sousa, Diana; Magalhães, Carina; Matafome, Paulo; Susana P. Pereira. "Adipose tissue-Liver Crosstalk: A route to hepatic dysfunction in pregnant women with obesity". Bioscience Reports (2024):
    Submitted
  3. Daniela Rosendo-Silva; Pedro Bastos Gomes; Tiago Rodrigues; Sofia Viana; André Nogueira da Costa; Philipp E. Scherer; Flávio Reis; et al. "Clinical and molecular profiling of human visceral adipose tissue reveals impairment of vascular architecture and remodeling as an early hallmark of dysfunction". Metabolism (2024): http://dx.doi.org/10.1016/j.metabol.2024.155788.
    10.1016/j.metabol.2024.155788
  4. Canário, Nádia S.; Crisóstomo, Joana; Moreno, Carolina; Duarte, João V.; Duarte, Isabel C.; Ribeiro, Mário; Caramelo, Beatriz; et al. "Functional reorganization of memory processing in the hippocampus is associated with neuroprotector GLP-1 levels in type 2 diabetes". Heliyon (2024): e27412. http://dx.doi.org/10.1016/j.heliyon.2024.e27412.
    10.1016/j.heliyon.2024.e27412
  5. Sónia Rocha; Andreia Marreiros Amaro; Marcos Divino Ferreira-Junior; Carina Proença; Artur M. S. Silva; Costa, V M; Sara Oliveira; et al. "Melanoxetin: A Hydroxylated Flavonoid Attenuates Oxidative Stress and Modulates Insulin Resistance and Glycation Pathways in an Animal Model of Type 2 Diabetes Mellitus". Pharmaceutics (2024): https://www.mdpi.com/1999-4923/16/2/261.
    10.3390/pharmaceutics16020261
  6. Tamaeh Monteiro-Alfredo; Maria Lígia Rodrigues Macedo; Kely de Picoli Souza; Paulo Matafome. "New Therapeutic Strategies for Obesity and Its Metabolic Sequelae: Brazilian Cerrado as a Unique Biome". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms242115588.
    10.3390/ijms242115588
  7. Sousa, Adelaide; Azevedo, Rui; Costa, Vera Marisa; Oliveira, Sara; Preguiça, Inês; Viana, Sofia; Reis, Flávio; et al. Corresponding author: Freitas, Marisa. "Biodistribution and intestinal inflammatory response following voluntary oral intake of silver nanoparticles by C57BL/6J mice". Archives of Toxicology 97 10 (2023): 2643-2657. http://dx.doi.org/10.1007/s00204-023-03558-5.
    10.1007/s00204-023-03558-5
  8. Amaro, Andreia; Sousa, Diana; Sá-Rocha, Mariana; Ferreira-Junior, Marcos Divino; Rosendo-Silva, Daniela; Saavedra, Lucas Paulo Jacinto; Barra, Cátia; et al. "Postnatal Overfeeding in Rodents Induces a Neurodevelopment Delay and Anxious-like Behaviour Accompanied by Sex- and Brain-Region-Specific Synaptic and Metabolic Changes". Nutrients 15 16 (2023): 3581. http://dx.doi.org/10.3390/nu15163581.
    10.3390/nu15163581
  9. Daniela Rosendo-Silva; Sofia Viana; Eugénia Carvalho; Flávio Reis; Paulo Matafome. "Are gut dysbiosis, barrier disruption, and endotoxemia related to adipose tissue dysfunction in metabolic disorders? Overview of the mechanisms involved". Internal and Emergency Medicine (2023): https://doi.org/10.1007/s11739-023-03262-3.
    10.1007/s11739-023-03262-3
  10. Paulo Matafome. "Nutritional Modulation of Dietary Sugars as a Strategy to Improve Insulin Resistance and Energy Balance in Diabetes". Diabetology (2023): https://doi.org/10.3390/diabetology4020018.
    10.3390/diabetology4020018
  11. Beatriz Caramelo; Tamaeh Monteiro-Alfredo; João Martins; José Sereno; João Castelhano; Bruno Manadas; Miguel Castelo-Branco; et al. Corresponding author: Matafome, Paulo. "Functional imaging and neurochemistry identify in vivo neuroprotection mechanisms counteracting excitotoxicity and neurovascular changes in the hippocampus and visual cortex of obese and type 2 diabetic animal models". Journal of Neurochemistry (2023): https://doi.org/10.1111/jnc.15825.
    10.1111/jnc.15825
  12. Diana Sousa; Mariana Rocha; Andreia Marreiros Amaro; Marcos Divino Ferreira-Junior; Keilah Valéria Naves Cavalcante; Tamaeh Monteiro-Alfredo; Tamaeh Monteiro Alfredo; Cátia Barra; et al. "Exposure to Obesogenic Environments during Perinatal Development Modulates Offspring Energy Balance Pathways in Adipose Tissue and Liver of Rodent Models". Nutrients (2023): https://www.mdpi.com/2072-6643/15/5/1281.
    10.3390/nu15051281
  13. Amaro A; Sousa D; Sá-Rocha M; Ferreira-Júnior MD; Barra C; Monteiro T; Mathias P; et al. "Sex-specificities in offspring neurodevelopment and behaviour upon maternal glycation: Putative underlying neurometabolic and synaptic changes.". Life sciences (2023): http://europepmc.org/abstract/med/36948389.
    10.1016/j.lfs.2023.121597
  14. Diana Sousa; Eduardo Lopes; Daniela Rosendo-Silva; Paulo Matafome. "The Bidirectional Relationship of NPY and Mitochondria in Energy Balance Regulation". Biomedicines (2023): https://doi.org/10.3390/biomedicines11020446.
    10.3390/biomedicines11020446
  15. Tavares, Gabriela; Rosendo-Silva, Daniela; Simoes, Flavia; Eickhoff, Hans; Marques, Daniela; Sacramento, Joana F.; Capucho, Adriana M.; et al. "Circulating Dopamine Is Regulated by Dietary Glucose and Controls Glucagon-like 1 Peptide Action in White Adipose Tissue". International Journal of Molecular Sciences (2023): https://publons.com/wos-op/publon/55340043/.
    10.3390/IJMS24032464
  16. Monteiro-Alfredo, Tamaeh; dos Santos, Jessica Maurino; Antunes, Katia Avila; Cunha, Janielle; Baldivia, Debora da Silva; Pires, Ana Salome; Marques, Ines; et al. "Acrocomia aculeata associated with doxorubicin: cardioprotection and anticancer activity". Frontiers in Pharmacology (2023): https://publons.com/wos-op/publon/61325685/.
    10.3389/FPHAR.2023.1223933
  17. Tamaeh Monteiro-Alfredo; Paulo Matafome. "Gut Metabolism of Sugars: Formation of Glycotoxins and Their Intestinal Absorption". Diabetology (2022): https://doi.org/10.3390/diabetology3040045.
    10.3390/diabetology3040045
  18. Regina Menezes; Paulo Matafome; Marisa Freitas; María-Teresa García-Conesa. "Updated Information of the Effects of (Poly)phenols against Type-2 Diabetes Mellitus in Humans: Reinforcing the Recommendations for Future Research". Nutrients (2022): https://doi.org/10.3390/nu14173563.
    10.3390/nu14173563
  19. Sara Oliveira; Tamaeh Monteiro-Alfredo; Rita Henriques; Carlos Fontes Ribeiro; Raquel Seiça; Cruz MT; Célia Cabral; et al. "Improvement of Glycaemia and Endothelial Function by a New Low-Dose Curcuminoid in an Animal Model of Type 2 Diabetes". International Journal of Molecular Sciences (2022): https://www.mdpi.com/1422-0067/23/10/5652.
    10.3390/ijms23105652
  20. Amaro, Andreia; Baptista, Filipa I.; Matafome, Paulo. "Programming of future generations during breastfeeding: The intricate relation between metabolic and neurodevelopment disorders". Life Sciences (2022): 120526. http://dx.doi.org/10.1016/j.lfs.2022.120526.
    Published • 10.1016/j.lfs.2022.120526
  21. Flávio A. Francisco , Lucas P. J. Saavedra, Marcos D. Ferreira-Junior, Keilah V. N. Cavalcante, Veridiana M. Moreira, Ke. "Early postnatal exposure of rat pups to methylglyoxal induces oxidative stress, inflammation and dysmetabolism at adulthood.". Journal of developmental origins of health and disease (2022): https://doi.org/10.1017/S204017442100074X.
    10.1017/s204017442100074x
  22. Lisandra Joaquim; Ana Faria; Helena Loureiro; Paulo Matafome. "Benefits, mechanisms, and risks of intermittent fasting in metabolic syndrome and type 2 diabetes". Journal of Physiology and Biochemistry (2022): https://doi.org/10.1007/s13105-021-00839-4.
    10.1007/s13105-021-00839-4
  23. Tânia B. Cruz; Filomena A. Carvalho; Paulo N. Matafome; Raquel A. Soares; Nuno C. Santos; Rui D. Travasso; Maria J. Oliveira. "Mice with Type 2 Diabetes Present Significant Alterations in Their Tissue Biomechanical Properties and Histological Features". Biomedicines (2021): https://doi.org/10.3390/biomedicines10010057.
    10.3390/biomedicines10010057
  24. Tavares, Gabriela; Martins, Fatima. O.; Melo, Bernardete. F.; Matafome, Paulo; Conde, Silvia. V.. "Peripheral Dopamine Directly Acts on Insulin-Sensitive Tissues to Regulate Insulin Signaling and Metabolic Function". Frontiers in Pharmacology 12 (2021): http://dx.doi.org/10.3389/fphar.2021.713418.
    10.3389/fphar.2021.713418
  25. Ana S. Pires; Carla L. Varela; Inês A. Marques; Ana M. Abrantes; Cristina Gonçalves; Tiago Rodrigues; Paulo Matafome; et al. "Oxymestane, a cytostatic steroid derivative of exemestane with greater antitumor activity in non-estrogen-dependent cell lines". The Journal of Steroid Biochemistry and Molecular Biology 212 (2021): 105950-105950. https://doi.org/10.1016/j.jsbmb.2021.105950.
    10.1016/j.jsbmb.2021.105950
  26. Tamaeh Monteiro-Alfredo; Beatriz Caramelo; Daniela Arbeláez; Andreia Amaro; Cátia Barra; Daniela Silva; Sara Oliveira; Raquel Seiça; Paulo Matafome. "Distinct Impact of Natural Sugars from Fruit Juices and Added Sugars on Caloric Intake, Body Weight, Glycaemia, Oxidative Stress and Glycation in Diabetic Rats". Nutrients 13 9 (2021): 2956-2956. https://doi.org/10.3390/nu13092956.
    10.3390/nu13092956
  27. Tamaeh Monteiro-Alfredo; Tamaeh Monteiro Alfredo; Sara Oliveira; Andreia Amaro; Daniela Rosendo-Silva; Katia Antunes; Pires AS; Ricardo Teixo; et al. "Hypoglycaemic and Antioxidant Properties of Acrocomia aculeata (Jacq.) Lodd Ex Mart. Extract Are Associated with Better Vascular Function of Type 2 Diabetic Rats". Nutrients (2021): https://www.mdpi.com/2072-6643/13/8/2856.
    10.3390/nu13082856
  28. Fátima O. Martins; Joana F. Sacramento; Elena Olea; Bernardete F. Melo; Jesus Prieto-Lloret; Ana Obeso; Asuncion Rocher; et al. "Chronic Intermittent Hypoxia Induces Early-Stage Metabolic Dysfunction Independently of Adipose Tissue Deregulation". Antioxidants 10 8 (2021): 1233-1233. https://doi.org/10.3390/antiox10081233.
    10.3390/antiox10081233
  29. Luís F. Grilo; Carolina Tocantins; Mariana S. Diniz; Rodrigo Mello Gomes; Paulo J. Oliveira; Paulo Matafome; Susana P. Pereira. "Metabolic Disease Programming: From Mitochondria to Epigenetics, Glucocorticoid Signalling and Beyond". European Journal of Clinical Investigation (2021): https://doi.org/10.1111/eci.13625.
    10.1111/eci.13625
  30. Rosendo-Silva, Daniela; Eickhoff, H; Gomes, P.; Viana, S.; AS Pires; Abrantes, Ana Margarida; Reis, F.; et al. "Alterations of the ghrelin/NPY adipose tissue system as a therapeutic target in type 2 diabetes". European Journal of Clinical Investigation 51 S1 (2021): http://dx.doi.org/10.1111/eci.13564.
    10.1111/eci.13564
  31. Margarida Sá-Marta; Mariana Marques; João Figueiredo; Ana Faria; Helena Loureiro; Sónia Fialho; Paulo Matafome. "Dietary Imbalance between Natural and Added Nutrient Sources Is Associated with Higher Fat Mass in Young Non-Obese Individuals". Diabetology (2021): https://doi.org/10.3390/diabetology2020008.
    10.3390/diabetology2020008
  32. Inês A. Marques; Ana M. Abrantes; Ana S. Pires; Ana R. Neves; Francisco J. Caramelo; Tiago Rodrigues; Paulo Matafome; et al. "Kinetics of radium-223 and its effects on survival, proliferation and DNA damage in lymph-node and bone metastatic prostate cancer cell lines". International Journal of Radiation Biology (2021): 1-16. https://doi.org/10.1080/09553002.2021.1906462.
    10.1080/09553002.2021.1906462
  33. Daniela Rosendo-Silva; Paulo Matafome. "Gut–adipose tissue crosstalk: A bridge to novel therapeutic targets in metabolic syndrome?". Obesity Reviews 22 2 (2021): https://doi.org/10.1111/obr.13130.
    10.1111/obr.13130
  34. Catalina Picó; Flávio Reis; Conceição Egas; Paulo Mathias; Paulo Matafome. "Lactation as a programming window for metabolic syndrome". European Journal of Clinical Investigation (2021): https://doi.org/10.1111/eci.13482.
    10.1111/eci.13482
  35. Francisco, F.A.; Saavedra, L.P.J.; Junior, M.D.F.; Barra, C.; Matafome, P.; Mathias, P.C.F.; Gomes, R.M.. "Early AGEing and metabolic diseases: Is perinatal exposure to glycotoxins programming for adult-life metabolic syndrome?". Nutrition Reviews 79 1 (2021): 13-24. http://www.scopus.com/inward/record.url?eid=2-s2.0-85098460824&partnerID=MN8TOARS.
    10.1093/nutrit/nuaa074
  36. Martinho, J.P.; Coelho, A.; Oliveiros, B.; Pires, S.; Abrantes, A.M.; Paulo, S.; Carvalho, A.C.; et al. "Impairment of the angiogenic process may contribute to lower success rate of root canal treatments in diabetes mellitus". International Endodontic Journal (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85109415325&partnerID=MN8TOARS.
    10.1111/iej.13572
  37. Silva-Teixeira, R.; Laranjo, M.; Lopes, B.; Almeida-Ferreira, C.; Gonçalves, A.C.; Rodrigues, T.; Matafome, P.; et al. "Plasma activated media and direct exposition can selectively ablate retinoblastoma cells". Free Radical Biology and Medicine 171 (2021): 302-313. http://www.scopus.com/inward/record.url?eid=2-s2.0-85106496334&partnerID=MN8TOARS.
    10.1016/j.freeradbiomed.2021.05.027
  38. Ferreira, A.S.; Galvão, S.; Gaspar, R.; Rodrigues-Neves, A.C.; Ambrósio, A.F.; Matafome, P.; Gomes, C.A.; Baptista, F.I.. "Sex-specific changes in peripheral metabolism in a model of chronic anxiety induced by prenatal stress". European Journal of Clinical Investigation (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85108261049&partnerID=MN8TOARS.
    10.1111/eci.13639
  39. Saavedra, L.P.J.; Prates, K.V.; Gonçalves, G.D.; Piovan, S.; Matafome, P.; Mathias, P.C.D.F.. "COVID-19 During Development: A Matter of Concern". Frontiers in Cell and Developmental Biology 9 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85104635646&partnerID=MN8TOARS.
    10.3389/fcell.2021.659032
  40. Tavares, G.; Marques, D.; Barra, C.; Rosendo-Silva, D.; Costa, A.; Rodrigues, T.; Gasparini, P.; et al. "Dopamine D2 receptor agonist, bromocriptine, remodels adipose tissue dopaminergic signalling and upregulates catabolic pathways, improving metabolic profile in type 2 diabetes". Molecular Metabolism 51 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85106861458&partnerID=MN8TOARS.
    10.1016/j.molmet.2021.101241
  41. Paulo Matafome. "Another Player in the Field: Involvement of Glycotoxins and Glycosative Stress in Insulin Secretion and Resistance". Diabetology (2020): https://www.mdpi.com/2673-4540/1/1/4.
    10.3390/diabetology1010004
  42. Sara Oliveira; Tamaeh Monteiro-Alfredo; Sónia Silva; Paulo Matafome. "Curcumin derivatives for Type 2 Diabetes management and prevention of complications". Archives of Pharmacal Research (2020): https://doi.org/10.1007/s12272-020-01240-3.
    10.1007/s12272-020-01240-3
  43. Matafome, Paulo. "A2 Adenosine Receptors Mediate Whole-Body Insulin Sensitivity in a Prediabetes Animal Model: Primary Effects on Skeletal Muscle". Frontiers in Endocrinology (2020): http://dx.doi.org/10.3389/fendo.2020.00262.
    10.3389/fendo.2020.00262
  44. Tamaeh Monteiro-Alfredo; Paulo Matafome; Bianca Pancoti Iacia; Kátia Ávila Antunes; Jéssica Maurino dos Santos; Janielle da Silva Melo da Cunha; Sara Oliveira; et al. "Acrocomia aculeata (Jacq.) Lodd. ex Mart. Leaves Increase SIRT1 Levels and Improve Stress Resistance". Oxidative Medicine and Cellular Longevity (2020): https://doi.org/10.1155/2020/5238650.
    10.1155/2020/5238650
  45. Castelhano, J.; Ribeiro, B.; Sanches, M.; Graça, B.; Saraiva, J.; Oliveiros, B.; Neves, C.; et al. "A rat model of enhanced glycation mimics cardiac phenotypic components of human type 2 diabetes : A translational study using MRI". Journal of Diabetes and its Complications (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85080056491&partnerID=MN8TOARS.
    10.1016/j.jdiacomp.2020.107554
  46. Matafome, P.. "Epicardial adipose tissue (dys)function: A new player in heart disease?,(Dis)função do tecido adiposo epicárdico: um novo interveniente nas doenças cardíacas?". Revista Portuguesa de Cardiologia 39 11 (2020): 635-637. http://www.scopus.com/inward/record.url?eid=2-s2.0-85095796133&partnerID=MN8TOARS.
    10.1016/j.repc.2020.10.001
  47. Rodrigues, T.; Borges, P.; Mar, L.; Marques, D.; Albano, M.; Eickhoff, H.; Carrêlo, C.; et al. "GLP-1 improves adipose tissue glyoxalase activity and capillarization improving insulin sensitivity in type 2 diabetes". Pharmacological Research 161 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85092033726&partnerID=MN8TOARS.
    10.1016/j.phrs.2020.105198
  48. Tesarova, Barbora; Dostalova, Simona; Smidova, Veronika; Goliasova, Zita; Skubalova, Zuzana; Michalkova, Hana; Hynek, David; et al. "Surface-PASylation of ferritin to form stealth nanovehicles enhances in vivo therapeutic performance of encapsulated ellipticine". Applied Materials Today 18 (2020): https://publons.com/wos-op/publon/28308249/.
    10.1016/J.APMT.2019.100501
  49. Letra, L.; Matafome, P.; Rodrigues, T.; Duro, D.; Lemos, R.; Baldeiras, I.; Patrcio, M.; et al. "Association between adipokines and biomarkers of Alzheimer's disease: A cross-sectional study". Journal of Alzheimer's Disease 67 2 (2019): 725-735. http://www.scopus.com/inward/record.url?eid=2-s2.0-85060571460&partnerID=MN8TOARS.
    10.3233/JAD-180669
  50. Letra, L.; Rodrigues, T.; Matafome, P.; Santana, I.; Seiça, R.. "Adiponectin and sporadic Alzheimer's disease: Clinical and molecular links". Frontiers in Neuroendocrinology 52 (2019): 1-11. http://www.scopus.com/inward/record.url?eid=2-s2.0-85031740092&partnerID=MN8TOARS.
    10.1016/j.yfrne.2017.10.002
  51. Melo, B.F.; Sacramento, J.F.; Ribeiro, M.J.; Prego, C.S.; Correia, M.C.; Coelho, J.C.; Cunha-Guimaraes, J.P.; et al. "Evaluating the Impact of Different Hypercaloric Diets on Weight Gain, Insulin Resistance, Glucose Intolerance, and its Comorbidities in Rats". Nutrients 11 6 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85067310280&partnerID=MN8TOARS.
    10.3390/nu11061197
  52. Eickhoff, H.; Rodrigues, T.; Neves, I.; Marques, D.; Ribeiro, D.; Costa, S.; Seiça, R.; Matafome, P.. "Effect of Sleeve Gastrectomy on Angiogenesis and Adipose Tissue Health in an Obese Animal Model of Type 2 Diabetes". Obesity Surgery (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85066888512&partnerID=MN8TOARS.
    10.1007/s11695-019-03935-z
  53. Neves, C.; Rodrigues, T.; Sereno, J.; Simões, C.; Castelhano, J.; Gonçalves, J.; Bento, G.; et al. "Dietary glycotoxins impair hepatic lipidemic profile in diet-induced obese rats causing hepatic oxidative stress and insulin resistance". Oxidative Medicine and Cellular Longevity 2019 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85070523456&partnerID=MN8TOARS.
    10.1155/2019/6362910
  54. Sena, Cristina M.; Eickhoff, Hans; Ribeiro, Diana; Matafome, Paulo; Seiça, Raquel. "Sleeve gastrectomy improves endothelial dysfunction in type 2 diabetic rats". Free Radical Biology and Medicine 120 (2018): S159. http://dx.doi.org/10.1016/j.freeradbiomed.2018.04.525.
    Published • 10.1016/j.freeradbiomed.2018.04.525
  55. Patrício, M.; Pereira, J.; Crisóstomo, J.; Matafome, P.; Gomes, M.; Seiça, R.; Caramelo, F.. "Using Resistin, glucose, age and BMI to predict the presence of breast cancer". BMC Cancer 18 1 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85042511022&partnerID=MN8TOARS.
    10.1186/s12885-017-3877-1
  56. da Costa, B.P.; Gonçalves, A.C.; Abrantes, A.M.; Alves, R.; Matafome, P.; Sarmento-Ribeiro, R.S.A.B.; Botelho, M.F.; Castro-Sousa, F.. "Tissular growth factors profile after teduglutide administration on an animal model of intestinal anastomosis,Perfil tisular de factores de crecimiento postadministración de teduglutida en un modelo animal de anastomosis intestinal". Nutricion Hospitalaria 35 1 (2018): 185-193. http://www.scopus.com/inward/record.url?eid=2-s2.0-85044216245&partnerID=MN8TOARS.
    10.20960/nh.1326
  57. Costa, B.P.; Gonçalves, A.C.; Abrantes, A.M.; Alves, R.; Matafome, P.; Seiça, R.; Sarmento-Ribeiro, A.B.; Botelho, M.F.; Castro-Sousa, F.. "Intestinal Epithelial Stem Cells: Distinct Behavior After Surgical Injury and Teduglutide Administration". Journal of Investigative Surgery 31 3 (2018): 243-252. http://www.scopus.com/inward/record.url?eid=2-s2.0-85016505953&partnerID=MN8TOARS.
    10.1080/08941939.2017.1294217
  58. Ribeiro, M.; Castelhano, J.; Petrella, L.I.; Sereno, J.; Rodrigues, T.; Neves, C.; Letra, L.; et al. "High-fat diet induces a neurometabolic state characterized by changes in glutamate and N-acetylaspartate pools associated with early glucose intolerance: An in vivo multimodal MRI study". Journal of Magnetic Resonance Imaging (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85041034539&partnerID=MN8TOARS.
    10.1002/jmri.25942
  59. Baptista, R.; Marques, C.; Catarino, S.; Enguita, F.J.; Costa, M.C.; Matafome, P.; Zuzarte, M.; et al. "MicroRNA-424(322) as a new marker of disease progression in pulmonary arterial hypertension and its role in right ventricular hypertrophy by targeting SMURF1". Cardiovascular Research 114 1 (2018): 53-64. http://www.scopus.com/inward/record.url?eid=2-s2.0-85040537877&partnerID=MN8TOARS.
    10.1093/cvr/cvx187
  60. Matafome, P.; Rodrigues, T.; Borges, P.; Carrelo, C.; Mar, L.; Eickhoff, H.; Almeida, B.; et al. "Targeting adipose tissue glyoxalase system with GLP-1 to improve capillarisation and insulin sensitivity". Diabetologia 61 (Sup.1) (2018): S110. https://publons.com/wos-op/publon/39159850/.
  61. Costa, B.P.; Cipriano, M.A.; Gonçalves, A.C.; Abrantes, A.M.; Matafome, P.; Seiça, R.; Sarmento-Ribeiro, A.B.; Botelho, M.F.; Castro-Sousa, F.. "Effects of teduglutide on histological parameters of intestinal anastomotic healing". European Surgery - Acta Chirurgica Austriaca 49 5 (2017): 218-227. http://www.scopus.com/inward/record.url?eid=2-s2.0-85018470904&partnerID=MN8TOARS.
    10.1007/s10353-017-0478-9
  62. Costa, B.P.; Gonçalves, A.C.; Abrantes, A.M.; Matafome, P.; Seiça, R.; Sarmento-Ribeiro, A.B.; Botelho, M.F.; Castro-Sousa, F.. "Teduglutide effects on gene regulation of fibrogenesis on an animal model of intestinal anastomosis". Journal of Surgical Research 216 (2017): 87-98. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019557502&partnerID=MN8TOARS.
    10.1016/j.jss.2017.04.022
  63. Da Costa, B.P.; Gonçalves, A.C.; Abrantes, A.M.; Matafome, P.; Seiça, R.; Sarmento-Ribeiro, A.B.; Botelho, M.F.; Castro-Sousa, F.. "Intestinal inflammatory and redox responses to the perioperative administration of teduglutide in rats". Acta Cirurgica Brasileira 32 8 (2017): 648-661. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029415807&partnerID=MN8TOARS.
    10.1590/s0102-865020170080000007
  64. Rodrigues, T.; Matafome, P.; Sereno, J.; Almeida, J.; Castelhano, J.; Gamas, L.; Neves, C.; et al. "Methylglyoxal-induced glycation changes adipose tissue vascular architecture, flow and expansion, leading to insulin resistance /692/163/2743/2037 /692/308/1426 /13/106 /59 /59/36 article". Scientific Reports 7 1 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85019208734&partnerID=MN8TOARS.
    10.1038/s41598-017-01730-3
  65. Matafome, P.; Rodrigues, T.; Sena, C.; Seiça, R.. "Methylglyoxal in Metabolic Disorders: Facts, Myths, and Promises". Medicinal Research Reviews 37 2 (2017): 368-403. http://www.scopus.com/inward/record.url?eid=2-s2.0-84987858663&partnerID=MN8TOARS.
    10.1002/med.21410
  66. Sacramento, J.F.; Ribeiro, M.J.; Rodrigues, T.; Olea, E.; Melo, B.F.; Guarino, M.P.; Fonseca-Pinto, R.; et al. "Functional abolition of carotid body activity restores insulin action and glucose homeostasis in rats: key roles for visceral adipose tissue and the liver". Diabetologia 60 1 (2017): 158-168. http://www.scopus.com/inward/record.url?eid=2-s2.0-84991325548&partnerID=MN8TOARS.
    10.1007/s00125-016-4133-y
  67. Crisóstomo, J.; Matafome, P.; Santos-Silva, D.; Gomes, A.L.; Gomes, M.; Patrício, M.; Letra, L.; et al. "Hyperresistinemia and metabolic dysregulation: a risky crosstalk in obese breast cancer". Endocrine 53 2 (2016): 433-442. http://www.scopus.com/inward/record.url?eid=2-s2.0-84958751473&partnerID=MN8TOARS.
    10.1007/s12020-016-0893-x
  68. Sacramento, J.F.; Ribeiro, M.J.; Rodrigues, T.; Guarino, M.P.; Diogo, L.N.; Seiça, R.; Monteiro, E.C.; Matafome, P.; Conde, S.V.. "Insulin resistance is associated with tissue-specific regulation of HIF-1a and HIF-2a during mild chronic intermittent hypoxia". Respiratory Physiology and Neurobiology 228 (2016): 30-38. http://www.scopus.com/inward/record.url?eid=2-s2.0-84961279467&partnerID=MN8TOARS.
    10.1016/j.resp.2016.03.007
  69. Lopes, A; Domingues, C; Neves, S; Matafome, Paulo; Seiça, R; Bernardino, A; Sarmento-Ribeiro, AB; Dourado, Marília. "Local anaesthetics as a new therapeutic approach in oral squamous cell carcinoma – an in vitro study.". Acta Médica Poruguesa - Student (2016):
    Published
  70. Eickhoff, H.; Louro, T.M.; Matafome, P.N.; Vasconcelos, F.; Seiça, R.M.; Castro e Sousa, F.. "Amelioration of Glycemic Control by Sleeve Gastrectomy and Gastric Bypass in a Lean Animal Model of Type 2 Diabetes: Restoration of Gut Hormone Profile". Obesity Surgery 25 1 (2015): 7-18. http://www.scopus.com/inward/record.url?eid=2-s2.0-84939893973&partnerID=MN8TOARS.
    10.1007/s11695-014-1309-8
  71. Santos-Oliveira, P.; Correia, A.; Rodrigues, T.; Ribeiro-Rodrigues, T.M.; Matafome, P.; Rodríguez-Manzaneque, J.C.; Seiça, R.; Girão, H.; Travasso, R.D.M.. "The Force at the Tip - Modelling Tension and Proliferation in Sprouting Angiogenesis". PLoS Computational Biology 11 8 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84940778593&partnerID=MN8TOARS.
    10.1371/journal.pcbi.1004436
  72. Martins-Marques, T.; Catarino, S.; Marques, C.; Matafome, P.; Ribeiro-Rodrigues, T.; Baptista, R.; Pereira, P.; Girão, H.. "Heart ischemia results in connexin43 ubiquitination localized at the intercalated discs". Biochimie 112 (2015): 196-201. http://www.scopus.com/inward/record.url?eid=2-s2.0-84964307751&partnerID=MN8TOARS.
    10.1016/j.biochi.2015.02.020
  73. Martins-Marques, T.; Catarino, S.; Zuzarte, M.; Marques, C.; Matafome, P.; Pereira, P.; Girão, H.. "Ischaemia-induced autophagy leads to degradation of gap junction protein connexin43 in cardiomyocytes". Biochemical Journal 467 2 (2015): 231-245. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930798449&partnerID=MN8TOARS.
    10.1042/BJ20141370
  74. Matafome, P.; Rodrigues, T.; Seiça, R.. "Glycation and Hypoxia: Two Key Factors for Adipose Tissue Dysfunction". Current Medicinal Chemistry 22 20 (2015): 2417-2437. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938651322&partnerID=MN8TOARS.
  75. Gamas, L.; Matafome, P.; Seica, R.. "Irisin and myonectin regulation in the insulin resistant muscle: Implications to adipose tissue: Muscle crosstalk". Journal of Diabetes Research 2015 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84929646308&partnerID=MN8TOARS.
    10.1155/2015/359159
  76. Eickhoff, H.; Louro, T.; Matafome, P.; Seiça, R.; Castro e Sousa, F.. "Glucagon secretion after metabolic surgery in diabetic rodents". Journal of Endocrinology 223 3 (2014): 255-265. http://www.scopus.com/inward/record.url?eid=2-s2.0-84911961407&partnerID=MN8TOARS.
    10.1530/JOE-14-0445
  77. Rodrigues, L.; Matafome, P.; Crisóstomo, J.; Santos-Silva, D.; Sena, C.; Pereira, P.; Seiça, R.. "Advanced glycation end products and diabetic nephropathy: A comparative study using diabetic and normal rats with methylglyoxal-induced glycation". Journal of Physiology and Biochemistry 70 1 (2014): 173-184. http://www.scopus.com/inward/record.url?eid=2-s2.0-84896355519&partnerID=MN8TOARS.
    10.1007/s13105-013-0291-2
  78. Matafome, P.; Rodrigues, T.; Pereira, A.; Letra, L.; Azevedo, H.; Paixão, A.; Silvério, M.; et al. "Long-term globular adiponectin administration improves adipose tissue dysmetabolism in high-fat diet-fed Wistar rats". Archives of Physiology and Biochemistry 120 4 (2014): 147-157. http://www.scopus.com/inward/record.url?eid=2-s2.0-84907529381&partnerID=MN8TOARS.
    10.3109/13813455.2014.950590
  79. Fernandes, R.; Bento, C.F.; Matafome, P.; Sena, C.M.; Seiça, R.M.; Pereira, P.. "Atorvastatin-mediated protection of the retina in a model of diabetes with hyperlipidemia". Canadian Journal of Physiology and Pharmacology 92 12 (2014): 1037-1043. http://www.scopus.com/inward/record.url?eid=2-s2.0-84912050638&partnerID=MN8TOARS.
    10.1139/cjpp-2014-0212
  80. Rodrigues, T.; Matafome, P.; Seiça, R.. "A vascular piece in the puzzle of adipose tissue dysfunction: Mechanisms and consequences". Archives of Physiology and Biochemistry 120 1 (2014): 1-11. http://www.scopus.com/inward/record.url?eid=2-s2.0-84893065442&partnerID=MN8TOARS.
    10.3109/13813455.2013.838971
  81. Cardoso, S.; Carvalho, C.; Marinho, R.; Simões, A.; Sena, C.M.; Matafome, P.; Santos, M.S.; Seiça, R.M.; Moreira, P.I.. "Effects of methylglyoxal and pyridoxamine in rat brain mitochondria bioenergetics and oxidative status". Journal of Bioenergetics and Biomembranes 46 5 (2014): 347-355. http://www.scopus.com/inward/record.url?eid=2-s2.0-84919396245&partnerID=MN8TOARS.
    10.1007/s10863-014-9551-2
  82. Sena, C.M.; Matafome, P.; Louro, T.; Nunes, E.; Seiça, R.M.. "Effects of atorvastatin and insulin in vascular dysfunction associated with type 2 diabetes". Physiological Research 63 2 (2014): 189-197. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899916325&partnerID=MN8TOARS.
  83. Rodrigues, T.; Matafome, P.; Seiça, R.. "Methylglyoxal further impairs adipose tissue metabolism after partial decrease of blood supply". Archives of Physiology and Biochemistry 119 5 (2013): 209-218. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887938844&partnerID=MN8TOARS.
    10.3109/13813455.2013.812121
  84. Matafome, P.; Santos-Silva, D.; Sena, C.M.; Seiça, R.. "Common mechanisms of dysfunctional adipose tissue and obesity-related cancers". Diabetes/Metabolism Research and Reviews 29 4 (2013): 285-295. http://www.scopus.com/inward/record.url?eid=2-s2.0-84877349617&partnerID=MN8TOARS.
    10.1002/dmrr.2395
  85. Crisóstomo, J.; Matafome, P.; Santos-Silva, D.; Rodrigues, L.; Sena, C.M.; Pereira, P.; Seiça, R.. "Methylglyoxal chronic administration promotes diabetes-like cardiac ischaemia disease in Wistar normal rats". Nutrition, Metabolism and Cardiovascular Diseases 23 12 (2013): 1223-1230. http://www.scopus.com/inward/record.url?eid=2-s2.0-84888838277&partnerID=MN8TOARS.
    10.1016/j.numecd.2013.01.005
  86. Almeida, F.; Santos-Silva, D.; Rodrigues, T.; Matafome, P.; Crisóstomo, J.; Sena, C.; Gonçalves, L.; Seiça, R.. "Pyridoxamine reverts methylglyoxal-induced impairment of survival pathways during heart ischemia". Cardiovascular Therapeutics 31 6 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84888334166&partnerID=MN8TOARS.
    10.1111/1755-5922.12039
  87. Rodrigues, T.; Matafome, P.; Santos-Silva, D.; Sena, C.; Seiça, R.. "Reduction of methylglyoxal-induced glycation by pyridoxamine improves adipose tissue microvascular lesions". Journal of Diabetes Research 2013 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84879402930&partnerID=MN8TOARS.
    10.1155/2013/690650
  88. Matafome, P.; Sena, C.; Seiça, R.. "Methylglyoxal, obesity, and diabetes". Endocrine 43 3 (2013): 472-484. http://www.scopus.com/inward/record.url?eid=2-s2.0-84877873718&partnerID=MN8TOARS.
    10.1007/s12020-012-9795-8
  89. Matafome, P.; Santos-Silva, D.; Crisóstomo, J.; Rodrigues, T.; Rodrigues, L.; Sena, C.M.; Pereira, P.; Seiça, R.. "Methylglyoxal causes structural and functional alterations in adipose tissue independently of obesity". Archives of Physiology and Biochemistry 118 2 (2012): 58-68. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860751778&partnerID=MN8TOARS.
    10.3109/13813455.2012.658065
  90. Sena, C.M.; Matafome, P.; Crisóstomo, J.; Rodrigues, L.; Fernandes, R.; Pereira, P.; Seiça, R.M.. "Methylglyoxal promotes oxidative stress and endothelial dysfunction". Pharmacological Research 65 5 (2012): 497-506. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859788536&partnerID=MN8TOARS.
    10.1016/j.phrs.2012.03.004
  91. Matafome, P.; Louro, T.; Rodrigues, L.; Crisóstomo, J.; Nunes, E.; Amaral, C.; Monteiro, P.; Cipriano, A.; Seiça, R.. "Metformin and atorvastatin combination further protect the liver in type 2 diabetes with hyperlipidaemia". Diabetes/Metabolism Research and Reviews 27 1 (2011): 54-62. http://www.scopus.com/inward/record.url?eid=2-s2.0-78651103598&partnerID=MN8TOARS.
    10.1002/dmrr.1157
  92. Rodrigues, L.; Crisóstomo, J.; Matafome, P.; Louro, T.; Nunes, E.; Seiça, R.. "Dietary restriction improves systemic and muscular oxidative stress in type 2 diabetic Goto-Kakizaki rats.". Journal of physiology and biochemistry 67 4 (2011): 613-619. http://www.scopus.com/inward/record.url?eid=2-s2.0-85027944303&partnerID=MN8TOARS.
  93. Sena, C.M.; Matafome, P.; Louro, T.; Nunes, E.; Fernandes, R.; Seiça, R.M.. "Metformin restores endothelial function in aorta of diabetic rats". British Journal of Pharmacology 163 2 (2011): 424-437. http://www.scopus.com/inward/record.url?eid=2-s2.0-79954561745&partnerID=MN8TOARS.
    10.1111/j.1476-5381.2011.01230.x
  94. Louro, T.M.; Matafome, P.N.; Nunes, E.C.; Xavier Da Cunha, F.; Seiça, R.M.. "Insulin and metformin may prevent renal injury in young type 2 diabetic Goto-Kakizaki rats". European Journal of Pharmacology 653 1-3 (2011): 89-94. http://www.scopus.com/inward/record.url?eid=2-s2.0-78651518054&partnerID=MN8TOARS.
    10.1016/j.ejphar.2010.11.029
  95. Crisóstomo, J.; Rodrigues, L.; Matafome, P.; Amaral, C.; Nunes, E.; Louro, T.; Monteiro, P.; Seiça, R.. "Beneficial effects of dietary restriction in type 2 diabetic rats: The role of adipokines on inflammation and insulin resistance". British Journal of Nutrition 104 1 (2010): 76-82. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954668427&partnerID=MN8TOARS.
    10.1017/S0007114510000164
  96. Bento, C.F.; Fernandes, R.; Matafome, P.; Sena, C.; Seia, R.; Pereira, P.. "Methylglyoxal-induced imbalance in the ratio of vascular endothelial growth factor to angiopoietin 2 secreted by retinal pigment epithelial cells leads to endothelial dysfunction". Experimental Physiology 95 9 (2010): 955-970. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955835661&partnerID=MN8TOARS.
    10.1113/expphysiol.2010.053561
  97. Santos, R.X.; Cardoso, S.; Silva, S.; Correia, S.; Carvalho, C.; Crisóstomo, J.; Rodrigues, L.; et al. "Food deprivation promotes oxidative imbalance in rat brain". Journal of Food Science 74 1 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-58649112769&partnerID=MN8TOARS.
    10.1111/j.1750-3841.2008.00982.x
  98. Sena, C.M.; Louro, T.; Matafome, P.; Nunes, E.; Monteiro, P.; Seiça, R.. "Antioxidant and vascular effects of gliclazide in type 2 diabetic rats fed high-fat diet". Physiological Research 58 2 (2009): 203-209. http://www.scopus.com/inward/record.url?eid=2-s2.0-66349113765&partnerID=MN8TOARS.
  99. Matafome, P.; Nunes, E.; Louro, T.; Amaral, C.; Crisóstomo, J.; Rodrigues, L.; Moedas, A.R.; et al. "A role for atorvastatin and insulin combination in protecting from liver injury in a model of type 2 diabetes with hyperlipidemia". Naunyn-Schmiedeberg's Archives of Pharmacology 379 3 (2009): 241-251. http://www.scopus.com/inward/record.url?eid=2-s2.0-59449088781&partnerID=MN8TOARS.
    10.1007/s00210-008-0363-y
  100. Matafome, P.; Monteiro, P.; Nunes, E.; Louro, T.; Amaral, C.; Moedas, A.R.; Gonçalves, L.; Providência, L.; Seiça, R.. "Therapeutic association of atorvastatin and insulin in cardiac ischemia: Study in a model of type 2 diabetes with hyperlipidemia". Pharmacological Research 58 3-4 (2008): 208-214. http://www.scopus.com/inward/record.url?eid=2-s2.0-54349104633&partnerID=MN8TOARS.
    10.1016/j.phrs.2008.07.005
  101. Nunes, E.; Peixoto, F.; Louro, T.; Sena, C.M.; Santos, M.S.; Matafome, P.; Moreira, P.I.; Seiça, R.. "Soybean oil treatment impairs glucose-stimulated insulin secretion and changes fatty acid composition of normal and diabetic islets". Acta Diabetologica 44 3 (2007): 121-130. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548177719&partnerID=MN8TOARS.
    10.1007/s00592-007-0252-8
Preprint
  1. Melo, Bernardete F.; Sacramento, Joana F.; Lavergne, Julien; Martins, Fátima O.; Rosendo-Silva, Daniela; Panzolini, Clara; Melo, Gonçalo M.; et al. "Ablation of carotid body activity reverses diabesity by improving white and brown adipose tissue sympathetic innervation and metabolism". 2023. http://dx.doi.org/10.1101/2023.08.04.552063.
    10.1101/2023.08.04.552063
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2020 Oral presentations by invitation - 20
2020 Oral and poster presentations in international meetings (first author) - 7 (2 oral)
2020 Oral and poster presentations in international meetings (last author) - 4 (2 oral)
2020 Oral and poster presentation in international meetings (other authors) - 45
2020 Oral presentations in national meetings (first author) - 10
2020 Oral presentations in national meetings (last author) - 6
2020 Poster presentations in national meetings (first author) - 29
2020 Poster presentations in national meetings (last author) - 8
2020 Oral and poster presentations in national meetings (other authors) - 115

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2022/10/01 - Current Depicting the intricate relation between neurodevelopmental disorders and nutrient-sensing pathways in the offspring upon in utero exposure to maternal diabetes
Supervisor
 Doctoral Programme in Health Sciences, area of Biomedical Sciences, Faculty of Medicine, University of Coimbra (PhD)
2022/05/01 - Current Relação entre exposição à radiação e obesidade para fins de diagnósticos e terapêutica
Co-supervisor
 Doutoramento em Biociências, especialização em Biotecnologia, Faculdade de Ciências e Tecnologia da Universidade de Coimbra (PhD)
2021 - Current A deep insight in obesity-associated human adipose tissue dysfunction: identifying new microbial and molecular markers for novel therapeutic approaches
Supervisor
 PhD em Ciências da Saúde (PhD)
Universidade de Coimbra Faculdade de Medicina, Portugal
2020/01/01 - Current Long-term effects of early overnutrition and maternal methylglyoxal treatment during the suckling period
Co-supervisor of Marcos Divino Ferreira Junior
 Programa de Pós-graduação em Ciências Biológicas (PhD)
Universidade Federal de Goiás, Brazil
2020 - Current Texture analysis of Optical Coherence Tomography retinal images as a novel and early predictor of diabetic retinopathy onset and progression
Co-supervisor
 Doctoral PhD em Ciências da Saúde (PhD)
Universidade de Coimbra Faculdade de Medicina, Portugal
2019 - Current Effectiveness of a GLP-1-based therapy as a novel intracanal medication dressing on apical periodontitis healing in diabetes
Co-supervisor
 PhD em Ciências da Saúde (PhD)
Universidade de Coimbra Faculdade de Medicina, Portugal
2016/06/01 - Current Targeting the carotid bodies to treat obesity
Supervisor of Bernardete Sofia de Freitas Melo
PhD em Mecanismos de Doença e Medicina Regenerativa (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Universidade de Coimbra Faculdade de Medicina, Portugal
2016/06/01 - Current Unraveling the role of peripheral dopaminergic signaling in metabolism
Supervisor of Gabriela Pires Tavares
 Programa Interuniversitário de Doutoramento em Envelhecimento e Doenças Crónicas (PhD)
Universidade de Coimbra Faculdade de Medicina, Portugal

Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2021/09/01 - 2022/07/31 Offspring Programming of central and peripheral nutrient-sensing pathways by the exposition to perinatal obesogenic environments
Supervisor
 Master in Cellular and Molecular Biology, Faculty of Sciences and Technology, University of Coimbra (Master)
2021/09/01 - 2022/07/31 Development of new imaging and biochemical markers of diabetic complications.
Supervisor
 Master in Cellular and Molecular Biology, Faculty of Sciences and Technology, University of Coimbra. (Master)
2021/09/01 - 2022/07/31 Effect of maternal glycation during lactation period on metabolism and neurodevelopment in lean and hyperphagic offspring rats.
Supervisor
 Master in Biochemistry, Faculty of Sciences and Technology, University of Coimbra (Master)
2021/09/01 - 2022/07/31 Postnatal programming of metabolic disease throughout life: the role of early glycotoxins exposure in the development of insulin resistance in normal and hyperphagic rats during lactation period.
Supervisor
 Master in Biochemistry, Faculty of Sciences and Technology, University of Coimbra. (Master)
2018/09/01 - 2021/10/29 Avaliação do potencial farmacológico do extrato aquoso das folhas de Acrocomia aculeata (Jacq.) Lodd ex. Mart.
Supervisor of Tamaeh Monteiro Alfredo
 Doutoramento em Ciências da Saúde (PhD)
Universidade de Coimbra Faculdade de Medicina, Portugal
2018 - 2021 Unraveling the role of peripheral dopaminergic signaling in metabolism
Supervisor
 Doutoramento em Ciência Biomédicas (PhD)
Universidade de Coimbra Faculdade de Medicina, Portugal
2017 - 2021 Targeting the carotid bodies to treat obesity
Co-supervisor
 PhD em Mecanismos de Doença e Medicina Regenerativa (PhD)
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2019/09/01 - 2020/10/01 The gut-adipose tissue crosstalk: Unravelling the mechanisms of ghrelin-mediated regulation of adipose tissue angiogenesis
Supervisor of Daniela Rosendo da Silva
 Mestrado em Biologia Celular e Molecular (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019 - 2019 Estudo do impacto dos produtos finais de glicação avançada em ratos recém-nascidos e avaliação dos mecanismos associados à desregulação metabólica na vida adulta
Supervisor of Mariana Sá Rocha
 Licenciatura em Biotecnologia (Degree)
Instituto Politécnico de Coimbra Escola Superior Agrária de Coimbra, Portugal
2015/01/01 - 2019 Ageing fat – exploring the mechanisms of glycation-induced microvascular dysfunction in adipose tissue
Co-supervisor of Tiago Daniel Almeida Rodrigues
 PhD em Ciências da Saúde (PhD)
Universidade de Coimbra Faculdade de Medicina, Portugal
2018 - 2018 Involvement of RAGE/AGEs axis on Non-alcoholic steatohepatits (NASH): a new potential mechanism of action of metformin
Co-supervisor of José André Nunes Marote
 Licencitura em Farmácia (Degree)
Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal
2018 - 2018 Effect of GLP-1R agonists in rat gastric fundus motility: Comparison with an animal model of type 2 Diabetes
Co-supervisor of Beatriz de Oliveira Martins
 Licenciatura em Química Medicinal (Degree)
2018 - 2018 Unraveling the role of peripheral dopamine in liver metabolism
Supervisor of Daniela Rosendo da Silva
 Licenciatura em Bioquímica (Degree)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018 - 2018 Unraveling the role of peripheral dopaminergic signaling in metabolism
Supervisor of Edit Fanny Bodin
 Licenciatura em Ciências Biomédicas Laboratoriais (Degree)
Universidade de Gotemburgo, Sweden
2017 - 2018 Unraveling the link between carotid body, insulin and dopamine
Supervisor of Paula de Fátima Pereira Cerqueira
 Mestrado Integrado em Medicina (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2017 - 2018 The therapeutic role of liraglutide in the modulation of adipose tissue angiogenesis
Supervisor of Laura do Mar Oliveira de Almeida Fonseca
 Mestrado Integrado em Medicina (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2017 - 2017 Peripheral dopamine as a modulator of insulin sensitivity
Supervisor of Rik Vanheuckelom
 Bachelor in Biomedical Laboratory Technology (Degree)
Thomas More - Campus Geel, Belgium
2017 - 2017 Angiogenesis in adipose tissue after bariatric surgery of diabetic rats, analysing Notch signalling
Supervisor of Susana Maria dos Santos Costa
 Licenciatura em Bioquímica (Degree)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2017 - 2017 Bromocriptine improves hepatic lipid and glucose metabolism: implications for Non-Alcoholic Fatty Liver Disease (NAFLD)
Supervisor of Ana Maria Reis Costa
 Licenciatura em Bioquímica (Degree)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016 - 2017 O metilglioxal altera o perfil lipídico no fígado de ratos obesos, induzindo insulino-resistência e contribuindo para a doença de fígado gordo não alcoólico
Supervisor of Christian André Fernandes Neves
 Mestrado Integrado em Medicina (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2016 - 2017 A Bromocriptina como moduladora do metabolismo lipídico no tecido adiposo e da sensibilidade à insulina na Diabetes Mellitus tipo 2
Supervisor of 9) Daniela Filipa Pereira Marques
 Mestrado em Patologia Experimental (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2016 - 2017 Alteração da sinalização dopaminérgica por desnervação do Corpo Carotídeo na modulação da função do Tecido Adiposo na Síndrome Metabólica
Supervisor of Ana Sofia Chasqueira dos Santos
 Mestrado em Bioquímica (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2015 - 2016 Irrigação do tecido adiposo após expansão induzida por dieta gorda e disfunção microvascular induzida por glicação
Supervisor of José Paulo Henriques Cabral Lopes de Almeida
 Mestrado Integrado em Medicina (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2015 - 2016 Alterações da motilidade gástrica na Diabetes Mellitus tipo II: o efeito dos agonistas do recetor do glucagon-like peptide I (GLP-1RA)
Co-supervisor of Ana Catarina Lourenço Carrêlo
 Mestrado em Farmacologia Aplicada (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2015 - 2015 Evaluating the role of glycation in adipose tissue irrigation during diet-induced obesity
Supervisor of Elinor Hansson Wilcken
 Licenciatura em Ciências Biomédicas Laboratoriais (Degree)
Universidade de Gotemburgo, Sweden
2015 - 2015 Mechanisms of insulin resistance in adipose tissue: does glycation further impair insulin signaling in hyperlipidemia?
Supervisor of Amina Arslanagic
 Licenciatura em Ciências Biomédicas Laboratoriais (Degree)
Universidade de Gotemburgo, Sweden
2014/09/01 - 2015 Irisina e insulino-resistência em modelos animais de obesidade e diabetes tipo 2
Co-supervisor of Luís Afonso Fialho Duarte Gamas
 Mestrado Integrado em Medicina (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2014/09/01 - 2015 O papel da glicação induzida por metilglioxal nos mecanismos da adipogénese
Co-supervisor of Catarina Santos Carvalho
 Mestrado Integrado em Medicina (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2014 - 2015 A glicação induzida por metilglioxal causa alterações do conteúdo lipídico-hepático e dismetabolismo em ratos com dieta gorda
Supervisor of Christian André Fernandes Neves
 Mestrado em Biomedicina Molecular (Master)
Universidade de Aveiro, Portugal
2012/09/01 - 2013 O efeito da glicação na sensibilidade à insulina durante a isquemia do tecido adiposo
Supervisor of Ana Beatriz dos Santos Amaral
 Mestrado Integrado em Medicina (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2010/09/01 - 2011 Os efeitos da inibição dos AGE's pela piridoxamina na lesão isquémica induzida por metilglioxal
Co-supervisor of Maria Filipa da Conceição Malheiro Pinto de Almeida
 Mestrado Integrado em Medicina (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2014 - Current Poster Week (1 evento por semestre) (2014)
Other (Co-organisor)
 Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal
2018 - 2018 Workshop on invasion and cell migration (2018 - 2018)
Workshop (Co-organisor)
 Universidade de Coimbra Faculdade de Medicina, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2019 Alterações cardiovasculares induzidas por supernutrição durante a lactação em ratos wistar na idade adulta
(Thesis) Main arguer
 Marcos Divino Ferreira Junior (Master)
Universidade Federal de Goiás, Brazil
2019 Tratamento materno com metilglioxal durante a lactação leva a disrupção da homeostase glicêmica da prole de ratos machos no início da vida
(Thesis) Main arguer
 Lucas Paulo Jacinto Saavedra (Master)
Universidade Estadual de Maringá, Brazil
2019 A exposição de metformina durante a lactação protege contra danos reprodutivos ocasionados pela dieta hiperlipídica em ratos machos adultos
(Thesis) Main arguer
 Henrique Rodrigues Vieira (Master)
Universidade Estadual de Maringá, Brazil
2019 Tratamento neonatal com metformina previne a síndrome metabólica na vida adulta
(Thesis) Main arguer
 Carina Previate (Master)
Universidade Estadual de Maringá, Brazil
2019 Macroalgas para Aplicações Alimentares: Ingredientes Naturais na Prevenção da Diabetes Tipo 2
(Thesis) Main arguer
 Ana Marta Cardoso Duarte (Master)
Instituto Politécnico de Leiria Escola Superior de Turismo e Tecnologia do Mar de Peniche, Portugal
2019 Radium-223 in metastatic prostate cancer: effects on metastasis microenvironment
(Thesis) Main arguer
 Nuno Tiago Fidalgo Tavares (Master)
Universidade de Aveiro, Portugal
2019 Sex-specificities of antenatal glucocorticoid exposure: focus on peripheral metabolism and glucose homeostasis
(Thesis) Main arguer
 Ana Sofia Lopes Ferreira (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2014 Carotid sinus nerve resection: therapeutic tool for the treatment of type 2 diabetes
(Thesis) Main arguer
 Bernardete Sofia de Freitas Melo (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal

Association member

Society Organization name Role
2019 - Current European Society of Clinical Investigation (ESCI)
2014 - Current European Association for the Study of Diabetes
2012 - Current Sociedade Portuguesa de Bioquímica (SPB)
2011 - Current Sociedade Portuguesa de Diabetologia (SPD)

Journal scientific committee

Journal title (ISSN) Publisher
2020 - Current International Journal of Diabetology Editorial Board Member
2013 - Current 27 manuscript revisions in international journals
Distinctions

Award

2018 Menção honrosa – Poster de investigação clínica, 14º Congresso Português de Diabetes
2018 Primeiro lugar do Prémio Eurico Lisboa 2018, Sociedade Portuguesa de Diabetes
2018 Menção honrosa do Prémio Eurico Lisboa 2018, Sociedade Portuguesa de Diabetes
2017 Melhor Comunicação oral em investigação clínica, 13º Congresso Português de Diabetes
2016 Prémio Nacional de Diabetologia, Sociedade Portuguesa de Diabetologia
2016 Prémio Prof. Manuel Hargreaves – SPD/Novartis, Sociedade Portuguesa de Diabetologia
2016 Best oral presentation, MIRCO-Medical Imaging And Radiotherapy Congress
2013 Young Scientist Award, European Congress of Cardiology
2011 Menção Honrosa do Prémio de Investigação Básica, XII Congresso Português de Endocrinologia
2010 Melhor Poster (Merck Serono), 10º Workshop de Diabetologia do Centro
2009 Melhor apresentação oral (Merck Serono), 9º Workshop de Diabetologia do Centro. Coimbra