João RamalhoSantos (0613-688D-A30E)

Curriculum Vitae

João RamalhoSantos

João Ramalho-Santos is Professor at the Department of Life Sciences, University of Coimbra, Portugal, where he concluded his Ph.D in Cell Biology in 1997. He was a post-doctoral fellow in Reproductive Biology at Oregon Health & Science University USA (1997-2000), a Visiting Scientist at University of Pittsburgh, USA (2003-2006) and a Fulbright Fellow at University of California San Francisco, USA (2009). He currently is the Head of the Biology of Reproduction and Stem Cells Group at the Center for Neuroscience and Cell Biology at the University of Coimbra (part of the CIBB Consortium) where he works on the bioenergetics and metabolism of gametes and stem cells, and on Science Communication using Comics and Bioethics issues related both to Assisted Reproduction and metabolism, aging and disease. He is Associate Editor of the Journals WIRE Mechanisms of Disease, International Journal of Molecular Sciences, Biomolecules, Fertility & Sterility- Science, Human Reproduction, FEBS Open, and Frontiers in Physiology, reviewer for over 100 journals and 15 agencies (Including FCT, Portugal, MRC, UK, FWO, Belgium, and DFG, Germany, as well as agencies in Estonia, Italy, Romania and Poland). He has over 500 Reviews and 320 Editorial Records in WoS, and is a member of the National Ethics Council for the Life Sciences (CNECV). h-Factor 52 (Google Scholar), 43 (ISI), 435 (Scopus). Citations: 10700 (Google Scholar), 6600 (ISI), 7300 (Scopus). Currently listed as one of the top 2% of cited researchers worldwide (career and year). He is also a renowned comic book expert, with both critical and historical analysis, and the production of both fictional and scientific communication comics, usually in collaboration with the Portuguese newspaper PÚBLICO.

Read full resume ↓

Identification

Personal identification

Full name: João RamalhoSantos
Date of birth: 1966/07/04
Gender: Male

Citation names

Ramalho-Santos, João

Author identifiers

Ciência ID: 0613-688D-A30E
ORCID iD: 0000-0002-1172-4018
Google Scholar ID: https://scholar.google.pt/citations?hl=en&user=6I6DIgYAAAAJ&view_op=list_works&cstart=0&pagesize=20
Researcher Id: F-8641-2012
Scopus Author Id: 798354

Email addresses

jramalho@uc.pt (Professional)

Telephones

Mobile phone

919588244 (Personal)

Addresses

Department of Life Sciences, Calçada Martim de Freitas, 3000-456, Coimbra, Coimbra, Portugal (Professional)

Websites

https://cnc.uc.pt/en/research-group/biology-of-reproduction-stem-cells (Professional)

Knowledge fields

Natural sciences - Biological Sciences
Medical and Health Sciences - Health Sciences
Natural sciences - Biological Sciences - Biochemistry
Medical and Health Sciences - Medical Biotechnology - Medical Biotechnology Related Ethics
Social Sciences - Media and Communications

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)
French	Advanced (C1)	Advanced (C1)	Intermediate (B1)	Advanced (C1)	Upper intermediate (B2)

Education

	Degree	Classification
2020 - 2020 Concluded	Medicina Narrativa (Curso de Especialização Tecnológica) Universidade Católica Portuguesa, Portugal	19
2013/01/20 Concluded	Agregação em Biociências (Título de Agregado) Universidade de Coimbra, Portugal	Approved
1997 Concluded	Biologia (Doutoramento) Major in Especialidade: Biologia Celular Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal "Actividade Fusogénica de Vírus com Envelope Lipídico - Fusão de Membranas Promovidas Pelos Vírus Influenza e Sendai" (THESIS/DISSERTATION)

Affiliation

Science

	Category Host institution	Employer
1997/09/01 - Current	Researcher (Research)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Teaching in Higher Education

	Category Host institution	Employer
2019/01/14 - Current	Full Professor (University Teacher)	Universidade de Coimbra, Portugal

2016 - 2018	Associate Professor (University Teacher)	Universidade de Coimbra, Portugal

2013 - 2016	Associate Professor (University Teacher)	Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Positions / Appointments

	Category Host institution	Employer
2017 - 2025	Conselho geral ou orgão correspondente	Universidade de Coimbra, Portugal

Projects

Grant

	Designation	Funders
2018/01/01 - 2021/12/31	HealthyAging2020 CENTRO-01-0145-FEDER-000012-N2323. Principal investigator Universidade de Coimbra, Portugal	Comissão de Coordenação e Desenvolvimento Regional do Centro Ongoing
2017/01/01 - 2021/12/31	HealthyAging CENTRO-01-0145-FEDER-000012-HealthyAging2020 Principal investigator Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal	Comissão de Coordenação e Desenvolvimento Regional do Centro FCT - Fundação para a Ciência e a Tecnologia Concluded
2019/05 - 2021/06	STEM@REST: A novel pluripotency stem cell state and its promise in stem cell bioengineering PTDC/BTM-SAL/28871/2017	Fundação para a Ciência e a Tecnologia
2018/03 - 2021/03	STEM@REST: A novel pluripotency stem cell state and its promise in stem cell bioengineering CENTRO-01-0145-FEDER-000012-N2323. CENTRO-01-0145-FEDER-028871	Fundação para a Ciência e a Tecnologia
2018/02 - 2021/02	INFERTILY2EXPLAIN: In search of novel biomarkers for unexplained human male infertility (CO-PI). CENTRO-01-0145-FEDER-028599	Fundação para a Ciência e a Tecnologia
2017/05/01 - 2020/03/31	LifeSciences byCENTRO. CENTRO-01-0246-FEDER-00001 Principal investigator CNC.IBILI, Portugal	Comissão de Coordenação e Desenvolvimento Regional do Centro Concluded
2016/01/01 - 2019/09/30	Healthy Lifestyle Innovation Quarters for Cities and Citizens (HeaLIQs4Cities). EIT-Health Researcher Universidade de Coimbra, Portugal	Concluded
2015/01/01 - 2018/12/31	Doctoral Program in Experimental Biology and Biomedicine (PDBEB) PD/00013/2013 Principal investigator CNC.IBILI, Portugal	Concluded
2012/10 - 2015/10	The role of the pyruvate dehydrogenase kinase as a metabolic switch in pluripotency: insights into cancer and stem cell biology PTDC/QUI-BIQ/120652/2010	FCT - Fundação para a Ciência e a Tecnologia
2012/10 - 2015/10	Metabolic modulation as a tool to create and propagate pluripotent stem cell lines PTDC/EBB-EBI/120634/2010	Fundação para a Ciência e a Tecnologia, I.P. & COMPETE 2020
2010/10 - 2014/10	Metabolism as a modulator of stem cell pluripotency and differentiation PTDC/EBB-EBI/101114/2008	FCT - Fundação para a Ciência e a Tecnologia
2010 - 2013	Skinengineering PTDC/SAU-OSM/099422/2008	Fundação para a Ciência e a Tecnologia, I.P.
2009/01/01 - 2009/06/30	INFLUENCE OF MITOCHONDRIAL METABOLISM ON EMBRYONIC STEM CELL PLURIPOTENCY AND DIFFERENTIATION SFRH/BSAB/860/2008 Universidade de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2009/01/01 - 2009/06/30	INFLUENCE OF MITOCHONDRIAL METABOLISM ON EMBRYONIC STEM CELL PLURIPOTENCY AND DIFFERENTIATION SFRH/BSAB/860/2008 Universidade de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Concluded
1998/01/01 - 2000/12/31	DINÂMICA E FUSÃO DE MEMBRANAS DURANTE A FERTILIZAÇÃO PRAXIS XXI/BPD/14144/97	Fundação para a Ciência e a Tecnologia Concluded
1998/01/01 - 2000/12/31	DINÂMICA E FUSÃO DE MEMBRANAS DURANTE A FERTILIZAÇÃO PRAXIS XXI/BPD/14144/97	Fundação para a Ciência e a Tecnologia Concluded

Contract

	Designation	Funders
2021/01/01 - 2025/12/31	Center for Innovative Biomedicine and Biotechnology - Associate Laboratory 10.54499/LA/P/0058/2020 Universidade de Coimbra, Portugal Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2021/01/01 - 2025/12/31	Center for Innovative Biomedicine and Biotechnology - Associate Laboratory 10.54499/LA/P/0058/2020 Universidade de Coimbra, Portugal Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018/07/06 - 2022/07/05	Searching for novel biomarkers in unknown origin male infertility PTDC/MEC-AND/28599/2017 Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018/07/06 - 2022/07/05	Searching for novel biomarkers in unknown origin male infertility PTDC/MEC-AND/28599/2017 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2018/07/06 - 2022/07/05	Searching for novel biomarkers in unknown origin male infertility PTDC/MEC-AND/28599/2017 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2018/06/01 - 2022/05/31	The Paused State: a novel way for bioengineering Stem Cell fate PTDC/BTM-SAL/28871/2017 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2018/06/01 - 2022/05/31	The Paused State: a novel way for bioengineering Stem Cell fate PTDC/BTM-SAL/28871/2017 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2017/01/01 - 2021/06/30	Tackling CANcer STEM CELls: a challenge and an opportunity to advance in anti-cancer therapy SAICTPAC/0022/2015 Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal Instituto Nacional de Engenharia Biomédica, Portugal Fundação Calouste Gulbenkian, Portugal Universidade de Coimbra, Portugal Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2017 - 2021	Merck Oncofertility Project Merck 003/2017 Researcher	Laboratoires Merck Sharp et Dohme-Chibret Centre de recherche Ongoing
2017/01/01 - 2020/12/31	Testing of spermicidal formulations NA Principal investigator Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Ongoing
2019/01/01 - 2019/12/31	CNC. IBILI UID/NEU/04539/2019 Universidade de Coimbra, Portugal Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2019/01/01 - 2019/12/31	Centre for the Research and Technology of Agro-Environmental and Biological Sciences UID/AGR/04033/2019 Universidade de Trás-os-Montes e Alto Douro Centro de Investigação e de Tecnologias Agro-Ambientais e Biologicas, Portugal Universidade de Trás-os-Montes e Alto Douro, Portugal Universidade do Minho, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2019/01/01 - 2019/12/31	CNC. IBILI UID/NEU/04539/2019 Universidade de Coimbra, Portugal Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2019/01/01 - 2019/12/31	Centre for the Research and Technology of Agro-Environmental and Biological Sciences UID/AGR/04033/2019 Universidade de Trás-os-Montes e Alto Douro Centro de Investigação e de Tecnologias Agro-Ambientais e Biologicas, Portugal Universidade de Trás-os-Montes e Alto Douro, Portugal Universidade do Minho, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2012/05/01 - 2015/09/30	New strategies to recover fertility and genetic variability of endangered felids: development of xenografting and spermatogonial stem cell transplantation in domestic cat as model for endangered felids PTDC/CVT/119477/2010 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2012/05/01 - 2015/09/30	New strategies to recover fertility and genetic variability of endangered felids: development of xenografting and spermatogonial stem cell transplantation in domestic cat as model for endangered felids PTDC/CVT/119477/2010 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2012/05/06 - 2015/09/05	Metabolic modulation as a tool to create and propagate pluripotent stem cell lines PTDC/EBB-EBI/120634/2010 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2012/05/06 - 2015/09/05	Metabolic modulation as a tool to create and propagate pluripotent stem cell lines PTDC/EBB-EBI/120634/2010 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2012/05/06 - 2015/08/31	Role of the pyruvate dehydrogenase kinase metabolic switch in pluripotency: insights into cancer and stem cell biology. PTDC/QUI-BIQ/120652/2010 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2012/05/06 - 2015/08/31	Role of the pyruvate dehydrogenase kinase metabolic switch in pluripotency: insights into cancer and stem cell biology. PTDC/QUI-BIQ/120652/2010 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2013/07/03 - 2015/01/02	Novel insights into the reproductive dysfunction in diabetes: 3D dimensional analysis of spermatogenesis and analysis of mitochondria status through Confocal Raman Microscopy EXPL/BEX-BCM/0224/2012 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2013/07/03 - 2015/01/02	Novel insights into the reproductive dysfunction in diabetes: 3D dimensional analysis of spermatogenesis and analysis of mitochondria status through Confocal Raman Microscopy EXPL/BEX-BCM/0224/2012 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2010/04/15 - 2013/10/14	Metabolism as a modulator of stem cell pluripotency and differentiation PTDC/EBB-EBI/101114/2008 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Karolinska Institutet, Sweden	Fundação para a Ciência e a Tecnologia Concluded
2010/04/15 - 2013/10/14	Metabolism as a modulator of stem cell pluripotency and differentiation PTDC/EBB-EBI/101114/2008 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Karolinska Institutet, Sweden	Fundação para a Ciência e a Tecnologia Concluded
2010/04/01 - 2013/03/31	Skingineering - Engineering skin analogues through cell sheet technology PTDC/SAU-OSM/099422/2008 Universidade do Minho, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2010/04/01 - 2013/03/31	Skingineering - Engineering skin analogues through cell sheet technology PTDC/SAU-OSM/099422/2008 Universidade do Minho, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2011/01/01 - 2012/12/31	Strategic Project - LA 1 - 2011-2012 PEst-C/SAU/LA0001/2011 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2011/01/01 - 2012/12/31	Strategic Project - LA 1 - 2011-2012 PEst-C/SAU/LA0001/2011 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2009/01/01 - 2011/12/31	Implementation of a Nacional Facility for DNA Microarrays: Phase II PTDC/BIA-BCM/64745/2006 Universidade de Aveiro, Portugal Universidade de Aveiro Centro de Estudos do Ambiente e do Mar, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2009/01/01 - 2011/12/31	Implementation of a Nacional Facility for DNA Microarrays: Phase II PTDC/BIA-BCM/64745/2006 Universidade de Aveiro, Portugal Universidade de Aveiro Centro de Estudos do Ambiente e do Mar, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2009/01/01 - 2011/12/31	Implementation of a Nacional Facility for DNA Microarrays: Phase II PTDC/BIA-BCM/64745/2006 Universidade de Aveiro, Portugal Universidade de Aveiro Centro de Estudos do Ambiente e do Mar, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2009/01/01 - 2009/06/30	INFLUENCE OF MITOCHONDRIAL METABOLISM ON EMBRYONIC STEM CELL PLURIPOTENCY AND DIFFERENTIATION SFRH/BSAB/860/2008 Universidade de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Concluded
1998/01/01 - 2000/12/31	DINÂMICA E FUSÃO DE MEMBRANAS DURANTE A FERTILIZAÇÃO PRAXIS XXI/BPD/14144/97	Fundação para a Ciência e a Tecnologia Concluded

Outputs

Publications

Book	Mireia Alemany i Pagès; João Ramalho-Santos; Anabela Marisa Azul; Rui Tavares. Sigues metge del teu propi fetge!. 2020. 10.14195/978-989-26-2118-0 Mireia Alemany i Pagès; João Ramalho-Santos; Anabela Marisa Azul; Rui Tavares. Eine gesunde Leber – nicht nur was für Streber. 2020. 10.14195/978-989-26-2120-3 Mireia Alemany i Pagès; João Ramalho-Santos; Anabela Marisa Azul; Rui Tavares. Un Fegato Sano Ti Porta Lontano!. 2020. 10.14195/978-989-26-2122-7 Mireia Alemany i Pagès; João Ramalho-Santos; Anabela Marisa Azul; Rui Tavares. La prochaine fois, pensez à ton foie!. 2020. 10.14195/978-989-26-2124-1 Mireia Alemany i Pagès; João Ramalho-Santos; Anabela Marisa Azul; Rui Tavares. Zdrowa watroba przy dlugim zyciu Cie zachowa!. 2020. 10.14195/978-989-26-2128-9 Mireia Alemany i Pagès; João Ramalho-Santos; Anabela Marisa Azul; Rui Tavares. ¡Un Hígado Equilibrado Es Medio Camino Andado!. 2020. 10.14195/978-989-26-2116-6 Mireia Alemany i Pagès; João Ramalho-Santos; Anabela Marisa Azul; Rui Tavares. Zdravá játra vždy splní své povinnosti!. 2020. 10.14195/978-989-26-2130-2 Mireia Alemany i Pagès; João Ramalho-Santos; Anabela Marisa Azul; Rui Tavares. Um Fígado Equilibrado é Meio Caminho Andado!. 2020. 10.14195/978-989-26-2041-1 Mireia Alemany i Pagès; João Ramalho-Santos; Anabela Marisa Azul; Rui Tavares. A Healthy Liver Will Always Deliver!. 2020. 10.14195/978-989-26-2040-4 João Ramalho-Santos; Rui Tavares. As Luzes do Príncipe. Sobre as experiências realizadas na Ilha do Príncipe em 1919, que ajudaram a validar a Teoria da Relatividade Geral. 2019. 10.14195/978-989-26-1831-9 Amaral, S.; Ramalho-Santos, J.. Free radical biology and reproductive health in diabetes. 2012. 10.1007/978-3-642-30018-9_115 Palmeira, C.M.; Ramalho-Santos, J.. Mitochondrial Dysfunction in Reproductive and Developmental toxicity. 2011. 10.1016/B978-0-12-382032-7.10061-X Amaral, A.; Sousa, A.P.; Campo, P.C.; Peregrín, P.C.; Ramalho-Santos, J.. Bioenergetics and male infertility: From basic science to clinical andrology. 2011.
Book chapter	Correia, B.; Sousa, M.I.; Branco, A.F.; Ramalho-Santos, J.. "Monitoring Mitochondrial Function in Mouse Embryonic Stem Cells (mESCs)". 47-56. 2021. 10.1007/978-1-0716-1433-4_4 Tavares, R.S.; Escada-Rebelo, S.; Soares, M.M.; Silva, A.F.; Almeida-Santos, T.; Amaral, S.; Sousa, A.P.; Ramalho-Santos, J.. "Mitochondrial Functional Assessment in Mammalian Gametes Using Fluorescent Probes". 57-68. 2021. 10.1007/978-1-0716-1433-4_5 Azul, A.M.; Ramalho-Santos, J.; Oliveira, P.J.; Tavares, R.. "Mitochondrial follies: A short journey in life and energy". 649-692. 2018. Amaral, S.; Tavares, R.S.; Escada-Rebelo, S.; Silva, A.F.; Ramalho-Santos, J.. "Mammalian Sperm Mitochondrial Function as Affected by Environmental Toxicants, Substances of Abuse, and Other Chemical Compounds". 185-203. 2018. Ramalho-Santos, J.; Tavares, R.S.. "Endocrine disruptors and male reproductive function". 629-633. 2018. Palmeira, C.M.; Ramalho-Santos, J.. "Mitochondrial dysfunction in reproductive and developmental toxicity". 1023-1035. 2017.
Conference paper	Pereira, A.K.; Sousa, A.P.; Santos, J.R.; Bernardino, J.. "Open source data mining tools evaluation using osspal methodology". 2019. 10.5220/0006907206720678
Journal article	João Ramalho-Santos. "Taking care of science: Towards better communication and societal engagement". European Journal of Clinical Investigation (2023): https://doi.org/10.1111/eci.13966. 10.1111/eci.13966 Mireia Alemany-Pagès; Rui Tavares; Anabela Marisa Azul; João Ramalho-Santos. "A Healthy Liver Will Always Deliver: Impact Study of a Non-Alcoholic Fatty Liver Disease (NAFLD) Awareness Comic". Health Communication (2023): https://doi.org/10.1080/10410236.2023.2215908. 10.1080/10410236.2023.2215908 Patrícia Pereira; Ana S. Neto; Ana S. Rodrigues; Inês Barros; Catarina Miranda; João Ramalho-Santos; Luís Pereira de Almeida; et al. "In Vitro Evaluation of Biphasic Calcium Phosphate Scaffolds Derived from Cuttlefish Bone Coated with Poly(ester urea) for Bone Tissue Regeneration". Polymers (2023): https://doi.org/10.3390/polym15102256. 10.3390/polym15102256 Maria Soares; Maria M. Pinto; Rui Jorge Nobre; Luís Pereira de Almeida; Maria da Graça Rasteiro; Teresa Almeida-Santos; João Ramalho-Santos; Ana Paula Sousa. "Isolation of Extracellular Vesicles from Human Follicular Fluid: Size-Exclusion Chromatography versus Ultracentrifugation". Biomolecules (2023): https://doi.org/10.3390/biom13020278. 10.3390/biom13020278 Ramalho-Santos, Joao. "The Forgotten". Nature (2023): https://publons.com/wos-op/publon/62244315/. 10.1038/D41586-023-01556-2 Ferreira, Ana Filipa; Soares, Maria; Almeida-Santos, Teresa; Ramalho-Santos, Joao; Sousa, Ana Paula. "Aging and oocyte competence: A molecular cell perspective". WIREs Mechanisms of Disease (2023): https://publons.com/wos-op/publon/51900964/. 10.1002/WSBM.1613 Vieira, Ines H.; Carvalho, Alexandra F.; Reis, Sandra Almeida; Carreira, Ana L.; Dias, Conceicao; Fernandes, Silvana; Ferreira, Ana Filipa; et al. "Association Between Follicle-Stimulating Hormone Receptor (FSHR) rs6166 and Estrogen Receptor 1 (ESR1) rs2234693 Polymorphisms and Polycystic Ovary Syndrome Risk, Phenotype, and Reproductive Outcomes in an Infertile Portuguese Population". Cureus (2023): https://publons.com/wos-op/publon/56907924/. 10.7759/CUREUS.35690 Branco, Ana; Moniz, Ines; Ramalho-Santos, Jao. "Mitochondria as biological targets for stem cell and organismal senescence". European Journal of Cell Biology (2023): https://publons.com/wos-op/publon/59591347/. 10.1016/J.EJCB.2023.151289 Mireia Alemany-Pagès; Rui Tavares; Anabela Marisa Azul; João Ramalho-Santos. "A healthy liver will always deliver: development of a NAFLD awareness comic". Health Promotion International (2022): https://doi.org/10.1093/heapro/daac165. 10.1093/heapro/daac165 Bibiana Correia; Maria Inês Sousa; Ana Filipa Branco; Ana Sofia Rodrigues; João Ramalho-Santos. "Leucine and Arginine Availability Modulate Mouse Embryonic Stem Cell Proliferation and Metabolism". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms232214286. 10.3390/ijms232214286 Inês Moniz; João Ramalho-Santos; Ana F. Branco. "Differential Oxygen Exposure Modulates Mesenchymal Stem Cell Metabolism and Proliferation through mTOR Signaling". International Journal of Molecular Sciences 23 7 (2022): 3749-3749. https://doi.org/10.3390/ijms23073749. 10.3390/ijms23073749 Sara Escada-Rebelo; Maria Inês Cristo; João Ramalho-Santos; Sandra Amaral. "Mitochondria-Targeted Compounds to Assess and Improve Human Sperm Function". Antioxidants & Redox Signaling (2022): https://doi.org/10.1089/ars.2021.0238. 10.1089/ars.2021.0238 Mireia Alemany-Pagès; Anabela Marisa Azul; João Ramalho-Santos. "The use of comics to promote health awareness: A template using nonalcoholic fatty liver disease". European Journal of Clinical Investigation (2022): https://doi.org/10.1111/eci.13642. 10.1111/eci.13642 Adriana Fontes; João Ramalho-Santos; Hans Zischka; Anabela Marisa Azul. "Mushrooms on the plate: Trends towards NAFLD treatment, health improvement and sustainable diets". European Journal of Clinical Investigation (2022): https://doi.org/10.1111/eci.13667. 10.1111/eci.13667 Mireia Alemany i Pagès; Rui Tavares; Anabela Marisa Azul; Joao Ramalho-Santos. "Translating Biochemistry Concepts into Cartoons and Graphic Narratives: Potential and Pitfalls". BioChem (2022): https://www.mdpi.com/2673-6411/2/1/8. 10.3390/biochem2010008 Tavares, R.; Alfaiate, M. I.; Carola, C.; Antonio Santos, R.; Sousa, A. P.; Almeida-Santos, T.; Ramalho-Santos, J.. "It takes two to tango: The involvement of certain environmental endocrine-disrupting chemicals in male infertility aetiology". European Journal of Clinical Investigation (2022): https://publons.com/wos-op/publon/56907928/. Reis, S.; Almeida-Santos, T.; Ramalho-Santos, J.; Sousa, A. P.. "Cumulus cells mitochondrial membrane potential as a marker of oocyte competence in assisted reproduction". Human Reproduction (2022): https://publons.com/wos-op/publon/56907926/. Cristo, M. I.; Pacheco, R.; Silva, A. F.; Sousa, A. P.; Moura-Ramos, M.; Almeida-Santos; Ramalho-Santos, J.; Amaral. "Proteomic approach to the characterization of unknown origin male infertility". European Journal of Clinical Investigation (2022): https://publons.com/wos-op/publon/55303388/. Ferreira, Ana Filipa; Machado-Simoes, Juliana; Soares, Maria; Sousa, Ana Paula; Ramalho-Santos, Joao; Almeida-Santos, Teresa. "Spatiotemporal dynamics of SIRT 1, 2 and 3 during in vitro maturation of bovine oocytes". Theriogenology (2022): https://publons.com/wos-op/publon/56907929/. 10.1016/J.THERIOGENOLOGY.2022.04.004 Ana Paula Sousa; Judith Santos-Pereira; Maria José Freire; Belmiro Parada; Teresa Almeida-Santos; Jorge Bernardino; João Ramalho-Santos. "Using Data Mining to Assist in Predicting Reproductive Outcomes Following Varicocele Embolization". Journal of Clinical Medicine 10 16 (2021): 3503-3503. https://doi.org/10.3390/jcm10163503. 10.3390/jcm10163503 Maria Inês Alfaiate; Rita António Santos; Andreia Filipa Silva; Ana Paula Sousa; Teresa Almeida-Santos; Célia Gendron; Violaine Jabbour; et al. "Comparative in vitro study on the local tolerance and efficacy of benzalkonium chloride, myristalkonium chloride and nonoxynol-9 as active principles in vaginal contraceptives". The European Journal of Contraception & Reproductive Health Care 26 4 (2021): 334-342. https://doi.org/10.1080/13625187.2021.1900563. 10.1080/13625187.2021.1900563 Tavares, R.S.; Ramalho-Santos, J.. "The role of sperm and oocyte in fetal programming: Is Lamarck making a comeback?". European Journal of Clinical Investigation 51 10 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85101900464&partnerID=MN8TOARS. 10.1111/eci.13521 Azul, A.M.; Almendra, R.; Quatorze, M.; Loureiro, A.; Reis, F.; Tavares, R.; Mota-Pinto, A.; et al. "Unhealthy lifestyles, environment, well-being and health capability in rural neighbourhoods: a community-based cross-sectional study". BMC public health 21 1 (2021): 1628-1628. http://www.scopus.com/inward/record.url?eid=2-s2.0-85115819445&partnerID=MN8TOARS. 10.1186/s12889-021-11661-4 Ferreira, A.F.; Soares, M.; Reis, S.A.; Ramalho-Santos, J.; Sousa, A.P.; Almeida-Santos, T.. "Does supplementation with mitochondria improve oocyte competence? A systematic review". Reproduction 161 3 (2021): 269-287. http://www.scopus.com/inward/record.url?eid=2-s2.0-85099646940&partnerID=MN8TOARS. 10.1530/REP-20-0351 Silva, A.F.; Ramalho-Santos, J.; Amaral, S.. "The impact of antisperm antibodies on human male reproductive function: An update". Reproduction 162 4 (2021): R55-R71. http://www.scopus.com/inward/record.url?eid=2-s2.0-85115783478&partnerID=MN8TOARS. 10.1530/REP-21-0123 Maria Inês Sousa; Bibiana Correia; Ana Filipa Branco; Ana Sofia Rodrigues; João Ramalho-Santos; Katia Mareschi. "Effects of DMSO on the Pluripotency of Cultured Mouse Embryonic Stem Cells (mESCs)". Stem Cells International (2020): https://doi.org/10.1155/2020/8835353. 10.1155/2020/8835353 Mireia Alemany-Pagès; Rui Tavares; Sara Varela Amaral; Ana Teresa Barros-Viegas; Paulo J. Oliveira; João Ramalho-Santos; Anabela Marisa Azul. "Publicly stressing the role of mitochondria in NAFLD with(in) a sports event". European Journal of Clinical Investigation (2020): https://doi.org/10.1111/eci.13234. 10.1111/eci.13234 Correia, B.; Sousa, M.I.; Ramalho-Santos, J.. "The mTOR pathway in reproduction: from gonadal function to developmental coordination". Reproduction (Cambridge, England) 159 4 (2020): R173-R188. http://www.scopus.com/inward/record.url?eid=2-s2.0-85079358628&partnerID=MN8TOARS. 10.1530/REP-19-0057 Rodrigues, A.S.; Pereira, S.L.; Ramalho-Santos, J.. "Stem metabolism: Insights from oncometabolism and vice versa". Biochimica et Biophysica Acta - Molecular Basis of Disease 1866 7 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85082398137&partnerID=MN8TOARS. 10.1016/j.bbadis.2020.165760 Sousa, M.I.; Correia, B.; Rodrigues, A.S.; Ramalho-Santos, J.. "Metabolic characterization of a paused-like pluripotent state". Biochimica et Biophysica Acta - General Subjects 1864 8 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85082759231&partnerID=MN8TOARS. 10.1016/j.bbagen.2020.129612 Alemany-Pagès, M.; Moura-Ramos, M.; Araújo, S.; MacEdo, M.P.; Ribeiro, R.T.; Do Ó, D.; Ramalho-Santos, J.; Azul, A.M.. "Insights from qualitative research on NAFLD awareness with a cohort of T2DM patients: Time to go public with insulin resistance?". BMC Public Health 20 1 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85088352232&partnerID=MN8TOARS. 10.1186/s12889-020-09249-5 Soares, M.; Sousa, A.P.; Fernandes, R.; Ferreira, A.F.; Almeida-Santos, T.; Ramalho-Santos, J.. "Aging-related mitochondrial alterations in bovine oocytes". Theriogenology 157 (2020): 218-225. http://www.scopus.com/inward/record.url?eid=2-s2.0-85089375099&partnerID=MN8TOARS. 10.1016/j.theriogenology.2020.07.036 Escada-Rebelo, S.; Mora, F.; Sousa, A.; Almeida-Santos, T.; Paiva, A.; Ramalho-Santos, J.. "Fluorescent probes for the detection of reactive oxygen species in human spermatozoa". Asian Journal of Andrology 22 5 (2020): 465-471. http://www.scopus.com/inward/record.url?eid=2-s2.0-85090027022&partnerID=MN8TOARS. 10.4103/aja.aja_132_19 Adriana Fontes; Mireia Alemany-Pagès; Paulo J. Oliveira; João Ramalho-Santos; Hans Zischka; Anabela Marisa Azul. "Antioxidant Versus Pro-Apoptotic Effects of Mushroom-Enriched Diets on Mitochondria in Liver Disease". International Journal of Molecular Sciences 20 16 (2019): 3987-3987. https://doi.org/10.3390/ijms20163987. 10.3390/ijms20163987 Marzano, G.; Chiriacò, M.S.; Primiceri, E.; Dell'Aquila, M.E.; Ramalho-Santos, J.; Zara, V.; Ferramosca, A.; Maruccio, G.. "Sperm selection in assisted reproduction: A review of established methods and cutting-edge possibilities". Biotechnology Advances (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85076859581&partnerID=MN8TOARS. 10.1016/j.biotechadv.2019.107498 Tavares, R.S.; Escada-Rebelo, S.; Sousa, M.I.; Silva, A.; Ramalho-Santos, J.; Amaral, S.. "Can antidiabetic drugs improve male reproductive (Dys)function associated with diabetes?". Current Medicinal Chemistry 26 22 (2019): 4191-4222. http://www.scopus.com/inward/record.url?eid=2-s2.0-85073177859&partnerID=MN8TOARS. 10.2174/0929867325666181101111404 Tavares, R.S.; Escada-Rebelo, S.; Silva, A.F.; Sousa, M.I.; Ramalho-Santos, J.; Amaral, S.. "Antidiabetic therapies and male reproductive function: where do we stand?". Reproduction 155 1 (2018): R13-R37. http://www.scopus.com/inward/record.url?eid=2-s2.0-85041534439&partnerID=MN8TOARS. 10.1530/REP-17-0390 Perestrelo, T.; Correia, M.; Ramalho-Santos, J.; Wirtz, D.. "Metabolic and Mechanical Cues Regulating Pluripotent Stem Cell Fate". Trends in Cell Biology 28 12 (2018): 1014-1029. http://www.scopus.com/inward/record.url?eid=2-s2.0-85055097062&partnerID=MN8TOARS. 10.1016/j.tcb.2018.09.005 Silva, A.F.; Escada-Rebelo, S.; Amaral, S.; Tavares, R.S.; Schlatt, S.; Ramalho-Santos, J.; Mota, P.C.. "Can we induce spermatogenesis in the domestic cat using an in vitro tissue culture approach?". PLoS ONE 13 2 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85041519878&partnerID=MN8TOARS. 10.1371/journal.pone.0191912 Ramalho-Santos, J.. "Data". Nature 555 7696 (2018): 408-408. http://www.scopus.com/inward/record.url?eid=2-s2.0-85044176678&partnerID=MN8TOARS. 10.1038/d41586-018-03054-2 Correia, M.; Perestrelo, T.; Rodrigues, A.S.; Ribeiro, M.F.; Pereira, S.L.; Sousa, M.I.; Ramalho-Santos, J.. "Sirtuins in metabolism, stemness and differentiation". Biochimica et Biophysica Acta - General Subjects 1861 1 (2017): 3444-3455. http://www.scopus.com/inward/record.url?eid=2-s2.0-84994527404&partnerID=MN8TOARS. 10.1016/j.bbagen.2016.09.008 Tavares, R.S.; Martins, S.; Almeida-Santos, T.; Sousa, A.P.; Ramalho-Santos, J.; da Cruz E Silva, O.A.. "Alzheimer’s disease-related amyloid-ß1–42 peptide induces the loss of human sperm function". Cell and Tissue Research (2017): 1-5. http://www.scopus.com/inward/record.url?eid=2-s2.0-85026841709&partnerID=MN8TOARS. 10.1007/s00441-017-2665-1 Tavares, R.S.; Portela, J.M.D.; Sousa, M.I.; Mota, P.C.; Ramalho-Santos, J.; Amaral, S.. "High glucose levels affect spermatogenesis: An in vitro approach". Reproduction, Fertility and Development 29 7 (2017): 1369-1378. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021107012&partnerID=MN8TOARS. 10.1071/RD15475 Perestrelo, T.; Chen, W.; Correia, M.; Le, C.; Pereira, S.; Rodrigues, A.S.; Sousa, M.I.; Ramalho-Santos, J.; Wirtz, D.. "Pluri-IQ: Quantification of Embryonic Stem Cell Pluripotency through an Image-Based Analysis Software". Stem Cell Reports 9 2 (2017): 697-709. http://www.scopus.com/inward/record.url?eid=2-s2.0-85023606018&partnerID=MN8TOARS. 10.1016/j.stemcr.2017.06.006 Marcelo Correia; Ana S. Rodrigues; Tânia Perestrelo; Sandro L. Pereira; Marcelo F. Ribeiro; Maria I. Sousa; João Ramalho-Santos. "Different concentrations of kaempferol distinctly modulate murine embryonic stem cell function". Food and Chemical Toxicology 87 (2016): 148-156. https://doi.org/10.1016%2Fj.fct.2015.12.011. 10.1016/j.fct.2015.12.011 Correia, M.; Sousa, M.I.; Rodrigues, A.S.; Perestrelo, T.; Pereira, S.L.; Ribeiro, M.F.; Ramalho-Santos, J.. "Data on the potential impact of food supplements on the growth of mouse embryonic stem cells". Data in Brief 7 (2016): 1190-1195. http://www.scopus.com/inward/record.url?eid=2-s2.0-84962815830&partnerID=MN8TOARS. 10.1016/j.dib.2016.03.098 Tavares, R.S.; Escada-Rebelo, S.; Correia, M.; Mota, P.C.; Ramalho-Santos, J.. "The non-genomic effects of endocrine-disrupting chemicals on mammalian sperm". Reproduction 151 1 (2016): R1-R13. http://www.scopus.com/inward/record.url?eid=2-s2.0-84958255751&partnerID=MN8TOARS. 10.1530/REP-15-0355 Crespo, Â.C.; van der Zwan, A.; Ramalho-Santos, J.; Strominger, J.L.; Tilburgs, T.. "Cytotoxic potential of decidual NK cells and CD8+ T cells awakened by infections". Journal of Reproductive Immunology (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84981737282&partnerID=MN8TOARS. 10.1016/j.jri.2016.08.001 Amaral, S.; Tavares, R.S.; Baptista, M.; Sousa, M.I.; Silva, A.; Escada-Rebelo, S.; Paiva, C.P.; Ramalho-Santos, J.. "Mitochondrial functionality and chemical compound action on sperm function". Current Medicinal Chemistry 23 31 (2016): 3575-3606. http://www.scopus.com/inward/record.url?eid=2-s2.0-84996565501&partnerID=MN8TOARS. 10.2174/0929867323666160425113518 Escada-Rebelo, S.; Silva, A.F.; Amaral, S.; Tavares, R.S.; Paiva, C.; Schlatt, S.; Ramalho-Santos, J.; Mota, P.C.. "Spermatogonial stem cell organization in felid testis as revealed by Dolichos biflorus lectin". Andrology (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84977654874&partnerID=MN8TOARS. 10.1111/andr.12223 Rodrigues, A.S.; Correia, M.; Gomes, A.; Pereira, S.L.; Perestrelo, T.; Sousa, M.I.; Ramalho-Santos, J.. "Dichloroacetate, the pyruvate dehydrogenase complex and the modulation of mESC pluripotency". PLoS ONE 10 7 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84940434831&partnerID=MN8TOARS. 10.1371/journal.pone.0131663 Portela, J.M.D.; Tavares, R.S.; Mota, P.C.; Ramalho-Santos, J.; Amaral, S.. "High glucose concentrations per se do not adversely affect human sperm function in vitro". Reproduction 150 1 (2015): 77-84. http://www.scopus.com/inward/record.url?eid=2-s2.0-84936772520&partnerID=MN8TOARS. 10.1530/REP-15-0100 Sousa, M.I.; Rodrigues, A.S.; Pereira, S.; Perestrelo, T.; Correia, M.; Ramalho-Santos, J.. "Mitochondrial Mechanisms of Metabolic Reprogramming in Proliferating Cells". Current Medicinal Chemistry 22 20 (2015): 2493-2504. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938575415&partnerID=MN8TOARS. Fonseca, N.A.; Rodrigues, A.S.; Rodrigues-Santos, P.; Alves, V.; Gregório, A.C.; Valério-Fernandes, Â.; Gomes-da-Silva, L.C.; et al. "Nucleolin overexpression in breast cancer cell sub-populations with different stem-like phenotype enables targeted intracellular delivery of synergistic drug combination". Biomaterials 69 (2015): 76-88. http://www.scopus.com/inward/record.url?eid=2-s2.0-84940734367&partnerID=MN8TOARS. 10.1016/j.biomaterials.2015.08.007 Paiva, C.; Amaral, A.; Rodriguez, M.; Canyellas, N.; Correig, X.; Ballescà, J.L.; Ramalho-Santos, J.; Oliva, R.. "Identification of endogenous metabolites in human sperm cells using proton nuclear magnetic resonance (¹H-NMR) spectroscopy and gas chromatography-mass spectrometry (GC-MS)". Andrology 3 3 (2015): 496-505. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929839766&partnerID=MN8TOARS. 10.1111/andr.12027 Tavares, R.S.; Amaral, S.; Paiva, C.; Baptista, M.; Ramalho-Santos, J.. "In vitro exposure to the organochlorine p,p'-DDE affects functional human sperm parameters". Chemosphere 120 (2015): 443-446. http://www.scopus.com/inward/record.url?eid=2-s2.0-84912104888&partnerID=MN8TOARS. 10.1016/j.chemosphere.2014.08.075 Rodrigues, A.S.; Pereira, S.L.; Correia, M.; Gomes, A.; Perestrelo, T.; Ramalho-Santos, J.. "Differentiate or die: 3-Bromopyruvate and pluripotency in mouse embryonic stem cells". PLoS ONE 10 8 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84942843640&partnerID=MN8TOARS. 10.1371/journal.pone.0135617 Cordeiro, M.H.; Kim, S.-Y.; Ebbert, K.; Duncan, F.E.; Ramalho-Santos, J.; Woodruff, T.K.. "Geography of follicle formation in the embryonic mouse ovary impacts activation pattern during the first wave of folliculogenesis". Biology of Reproduction 93 4 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84947290970&partnerID=MN8TOARS. 10.1095/biolreprod.115.131227 Amaral, S.V.; Forte, T.; Ramalho-Santos, J.; Da Cruz, M.T.G.. "I want more and better cells! - An outreach project about stem cells and its impact on the general population". PLoS ONE 10 7 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84941929963&partnerID=MN8TOARS. 10.1371/journal.pone.0133753 Amaral, A.; Castillo, J.; Ramalho-Santos, J.; Oliva, R.. "The combined human sperm proteome: Cellular pathways and implications for basic and clinical science". Human Reproduction Update 20 1 (2014): 40-62. http://www.scopus.com/inward/record.url?eid=2-s2.0-84889633604&partnerID=MN8TOARS. 10.1093/humupd/dmt046 Lourenço, B.; Sousa, A.P.; Almeida-Santos, T.; Ramalho-Santos, J.. "Relation of cumulus cell status with single oocyte maturity, fertilization capability and patient age". Journal of Reproduction and Infertility 15 1 (2014): 15-21. http://www.scopus.com/inward/record.url?eid=2-s2.0-84895893874&partnerID=MN8TOARS. Ramalho-Santos, J.. "Sins of the fathers: Sperm DNA damage in the context of assisted reproduction". Human Reproduction 29 11 (2014): 2356-2358. http://www.scopus.com/inward/record.url?eid=2-s2.0-84913586642&partnerID=MN8TOARS. 10.1093/humrep/deu229 Amaral, A.; Paiva, C.; Attardo Parrinello, C.; Estanyol, J.M.; Ballescà, J.L.; Ramalho-Santos, J.; Oliva, R.. "Identification of proteins involved in human sperm motility using high-throughput differential proteomics". Journal of Proteome Research 13 12 (2014): 5670-5684. http://www.scopus.com/inward/record.url?eid=2-s2.0-84915748593&partnerID=MN8TOARS. 10.1021/pr500652y Marques, M.; Sousa, A.P.; Paiva, A.; Almeida-Santos, T.; Ramalho-Santos, J.. "Low amounts of mitochondrial reactive oxygen species define human sperm quality". Reproduction 147 6 (2014): 817-824. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901660651&partnerID=MN8TOARS. 10.1530/REP-13-0644 Ramalho-Santos, J.. "Emancipation". Nature 510 7505 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84902971393&partnerID=MN8TOARS. 10.1038/510436a Pereira, S.L.; Rodrigues, A.S.; Sousa, M.I.; Correia, M.; Perestrelo, T.; Ramalho-Santos, J.. "From gametogenesis and stem cells to cancer: Common metabolic themes". Human Reproduction Update 20 6 (2014): 924-943. http://www.scopus.com/inward/record.url?eid=2-s2.0-84913602111&partnerID=MN8TOARS. 10.1093/humupd/dmu034 Sousa, M.I.; Amaral, S.; Tavares, R.S.; Paiva, C.; Ramalho-Santos, J.. "Concentration-dependent Sildenafil citrate (Viagra) effects on ROS production, energy status, and human sperm function". Systems Biology in Reproductive Medicine 60 2 (2014): 72-79. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901672805&partnerID=MN8TOARS. 10.3109/19396368.2013.867380 Baptista, M.; Tavares, R.; Ramalho-Santos, J.. "Spermicidal and microbicidal compounds: In search of an efficient multipurpose strategy". Current Medicinal Chemistry 21 32 (2014): 3693-3700. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929093972&partnerID=MN8TOARS. Baptista, M.; Publicover, S.J.; Ramalho-Santos, J.. "In vitro effects of cationic compounds on functional human sperm parameters". Fertility and Sterility 99 3 (2013): 705-712. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875230252&partnerID=MN8TOARS. 10.1016/j.fertnstert.2012.11.008 Pereira, S.L.; Grãos, M.; Rodrigues, A.S.; Anjo, S.I.; Carvalho, R.A.; Oliveira, P.J.; Arenas, E.; Ramalho-Santos, J.. "Inhibition of mitochondrial complex III blocks neuronal differentiation and maintains embryonic stem cell pluripotency". PLoS ONE 8 12 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84891590984&partnerID=MN8TOARS. 10.1371/journal.pone.0082095 Carvalho, A.S.; Ramalho-Santos, J.. "How can ethics relate to science? The case of stem cell research.". European journal of human genetics : EJHG 21 6 (2013): 591-595. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885931079&partnerID=MN8TOARS. 10.1038/ejhg.2012.232 Amaral, A.; Castillo, J.; Estanyol, J.M.; Ballesca, J.L.; Ramalho-Santos, J.; Oliva, R.. "Human sperm tail proteome suggests new endogenous metabolic pathways". Molecular and Cellular Proteomics 12 2 (2013): 330-342. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874070103&partnerID=MN8TOARS. 10.1074/mcp.M112.020552 Pereira, S.P.; Pereira, G.C.; Pereira, C.V.; Carvalho, F.S.; Cordeiro, M.H.; Mota, P.C.; Ramalho-Santos, J.; Moreno, A.J.; Oliveira, P.J.. "Dioxin-induced acute cardiac mitochondrial oxidative damage and increased activity of ATP-sensitive potassium channels in Wistar rats". Environmental Pollution 180 (2013): 281-290. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879443261&partnerID=MN8TOARS. 10.1016/j.envpol.2013.05.049 Tavares, R.S.; Silva, A.F.; Lourenço, B.; Almeida-Santos, T.; Sousa, A.P.; Ramalho-Santos, J.. "Evaluation of human sperm chromatin status after selection using a modified Diff-Quik stain indicates embryo quality and pregnancy outcomes following in vitro fertilization". Andrology 1 6 (2013): 830-837. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886438897&partnerID=MN8TOARS. 10.1111/j.2047-2927.2013.00127.x Alçada-Morais, S.; Sousa, A.P.; Paiva, A.; Almeida-Santos, T.; Ramalho-Santos, J.. "Anterior positioning of sex chromosomes on the head of human sperm sorted using visible wavelengths". Systems Biology in Reproductive Medicine 59 4 (2013): 223-226. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880667497&partnerID=MN8TOARS. 10.3109/19396368.2013.787129 Alasmari, W.; Costello, S.; Correia, J.; Oxenham, S.K.; Morris, J.; Fernandes, L.; Ramalho-Santos, J.; et al. "Ca2+ signals generated by CatSper and Ca2+ stores regulate different behaviors in human sperm". Journal of Biological Chemistry 288 9 (2013): 6248-6258. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874775558&partnerID=MN8TOARS. 10.1074/jbc.M112.439356 Amaral, S.; Redmann, K.; Sanchez, V.; Mallidis, C.; Ramalho-Santos, J.; Schlatt, S.. "UVB irradiation as a tool to assess ROS-induced damage in human spermatozoa". Andrology 1 5 (2013): 707-714. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883044268&partnerID=MN8TOARS. 10.1111/j.2047-2927.2013.00098.x Tavares, R.S.; Mansell, S.; Barratt, C.L.; Wilson, S.M.; Publicover, S.J.; Ramalho-Santos, J.. "p,p'-DDE activates CatSper and compromises human sperm function at environmentally relevant concentrations.". Human reproduction (Oxford, England) 28 12 (2013): 3167-3177. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901256099&partnerID=MN8TOARS. Amaral, A.; Ramalho-Santos, J.. "The male gamete is not a somatic cell-the possible meaning of varying sperm RNA levels". Antioxidants and Redox Signaling 18 2 (2013): 179-180. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870488121&partnerID=MN8TOARS. 10.1089/ars.2012.4715 Ramalho-Santos, J.; Amaral, S.. "Mitochondria and mammalian reproduction". Molecular and Cellular Endocrinology 379 1-2 (2013): 74-84. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884535027&partnerID=MN8TOARS. 10.1016/j.mce.2013.06.005 Amaral, A.; Lourenço, B.; Marques, M.; Ramalho-Santos, J.. "Mitochondria functionality and sperm quality". Reproduction 146 5 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84885668589&partnerID=MN8TOARS. 10.1530/REP-13-0178 Amaral, S.; Amaral, A.; Ramalho-Santos, J.. "Aging and male reproductive function: A mitochondrial perspective". Frontiers in Bioscience - Scholar 5 S 1 (2013): 181-197. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883217042&partnerID=MN8TOARS. Ramalho-Santos, J.. "Invisible". Nature 483 7391 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84859173556&partnerID=MN8TOARS. 10.1038/483642a Mota, P.C.; Ehmcke, J.; Westernströer, B.; Gassei, K.; Ramalho-Santos, J.; Schlatt, S.. "Effects of different storage protocols on cat testis tissue potential for xenografting and recovery of spermatogenesis". Theriogenology 77 2 (2012): 299-310. http://www.scopus.com/inward/record.url?eid=2-s2.0-84855565118&partnerID=MN8TOARS. 10.1016/j.theriogenology.2011.07.042 RamalhoSantos, João; Mota, P.C.; Tavares, R.S.; Cordeiro, M.; Pereira, S.P.; Publicover, S.J.; Oliveira, P.J.; Ramalho-Santos, J.. "Acute effects of TCDD administration: special emphasis on testicular and sperm mitochondrial function". Asian Pacific Journal of Reproduction 1 4 (2012): 269-276. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929141935&partnerID=MN8TOARS. 10.1016/s2305-0500(13)60091-3 Pereira, S.L.; Ramalho-Santos, J.; Branco, A.F.; Sardão, V.A.; Oliveira, P.J.; Carvalho, R.A.. "Metabolic remodeling during H9c2 myoblast differentiation: Relevance for in vitro toxicity studies". Cardiovascular Toxicology 11 2 (2011): 180-190. http://www.scopus.com/inward/record.url?eid=2-s2.0-79958056642&partnerID=MN8TOARS. 10.1007/s12012-011-9112-4 Inácio, A.S.; Mesquita, K.A.; Baptista, M.; Ramalho-Santos, J.; Vaz, W.L.C.; Vieira, O.V.. "In vitro surfactant structure-toxicity relationships: Implications for surfactant use in sexually transmitted infection prophylaxis and contraception". PLoS ONE 6 5 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-79956121318&partnerID=MN8TOARS. 10.1371/journal.pone.0019850 Amaral, A.; Paiva, C.; Baptista, M.; Sousa, A.P.; Ramalho-Santos, J.. "Exogenous glucose improves long-standing human sperm motility, viability, and mitochondrial function". Fertility and Sterility 96 4 (2011): 848-850. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053337018&partnerID=MN8TOARS. 10.1016/j.fertnstert.2011.07.1091 Ramalho-Santos, J.. "Human procreation in unchartered territory: New twists in ethical discussions". Human Reproduction 26 6 (2011): 1284-1287. http://www.scopus.com/inward/record.url?eid=2-s2.0-79957525813&partnerID=MN8TOARS. 10.1093/humrep/der093 Mota, P.C.; Cordeiro, M.; Pereira, S.P.; Oliveira, P.J.; Moreno, A.J.; Ramalho-Santos, J.. "Differential effects of p,p'-DDE on testis and liver mitochondria:Implications for reproductive toxicology". Reproductive Toxicology 31 1 (2011): 80-85. http://www.scopus.com/inward/record.url?eid=2-s2.0-79551613557&partnerID=MN8TOARS. 10.1016/j.reprotox.2010.09.010 Varum, S.; Rodrigues, A.S.; Moura, M.B.; Momcilovic, O.; Easley IV, C.A.; Ramalho-Santos, J.; van Houten, B.; Schatten, G.. "Energy metabolism in human pluripotent stem cells and their differentiated counterparts". PLoS ONE 6 6 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-79959221064&partnerID=MN8TOARS. 10.1371/journal.pone.0020914 Sousa, A.P.; Amaral, A.; Baptista, M.; Tavares, R.; Campo, P.C.; Peregrín, P.C.; Freitas, A.; et al. "Not all sperm are equal: Functional mitochondria characterize a subpopulation of human sperm with better fertilization potential". PLoS ONE 6 3 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-79952915040&partnerID=MN8TOARS. 10.1371/journal.pone.0018112 Ramalho-Santos, J.. "Variants". Nature 474 7352 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-79959570837&partnerID=MN8TOARS. 10.1038/474536a Paula C. Mota; João Ramalho-Santos; Stefan Schlatt. "Xenografting as a Tool to Preserve Endangered Species: Outcomes and Challenges in Model Systems". Veterinary Medicine International 2011 (2011): 1-7. http://dx.doi.org/10.4061/2011/629409. 10.4061/2011/629409 Ramalho-Santos, J.. "A sperms tail: The importance of getting it right". Human Reproduction 26 9 (2011): 2590-2591. http://www.scopus.com/inward/record.url?eid=2-s2.0-80051919982&partnerID=MN8TOARS. 10.1093/humrep/der200 Rodrigues, A.S.; Lacerda, B.; Moreno, A.J.M.; Ramalho-Santos, J.. "Proton leak modulation in testicular mitochondria affects reactive oxygen species production and lipid peroxidation". Cell Biochemistry and Function 28 3 (2010): 224-231. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953555150&partnerID=MN8TOARS. 10.1002/cbf.1644 Gamboa, S.; Rodrigues, A.S.; Henriques, L.; Batista, C.; Ramalho-Santos, J.. "Seasonal functional relevance of sperm characteristics in equine spermatozoa". Theriogenology 73 7 (2010): 950-958. http://www.scopus.com/inward/record.url?eid=2-s2.0-77949335544&partnerID=MN8TOARS. 10.1016/j.theriogenology.2009.11.023 Amaral, A.; Ramalho-Santos, J.. "Assessment of mitochondrial potential: Implications for the correct monitoring of human sperm function". International Journal of Andrology 33 1 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-74349089527&partnerID=MN8TOARS. 10.1111/j.1365-2605.2009.00987.x Amaral S; Ramalho-Santos J; Amaral, S.; Ramalho-Santos, J.. "Aging, mitochondria and male reproductive function.". Current Aging Science 2 3 (2009): 165-173. http://europepmc.org/abstract/med/20021411. 10.2174/1874609810902030165 Ramalho-Santos, J.; Varum, S.; Amaral, S.; Mota, P.C.; Sousa, A.P.; Amaral, A.. "Mitochondrial functionality in reproduction: From gonads and gametes to embryos and embryonic stem cells". Human Reproduction Update 15 5 (2009): 553-572. http://www.scopus.com/inward/record.url?eid=2-s2.0-69049087814&partnerID=MN8TOARS. 10.1093/humupd/dmp016 Tavares, R.S.; Martins, F.C.; Oliveira, P.J.; Ramalho-Santos, J.; Peixoto, F.P.. "Parabens in male infertility-Is there a mitochondrial connection?". Reproductive Toxicology 27 1 (2009): 1-7. http://www.scopus.com/inward/record.url?eid=2-s2.0-58749116602&partnerID=MN8TOARS. 10.1016/j.reprotox.2008.10.002 Varum, S.; Momcilovic, O.; Castro, C.; Ben-Yehudah, A.; Ramalho-Santos, J.; Navara, C.S.. "Enhancement of human embryonic stem cell pluripotency through inhibition of the mitochondrial respiratory chain". Stem Cell Research 3 2-3 (2009): 142-156. http://www.scopus.com/inward/record.url?eid=2-s2.0-70349860263&partnerID=MN8TOARS. 10.1016/j.scr.2009.07.002 Mota, P.; Amaral, S.; Martins, L.; de Lourdes Pereira, M.; Oliveira, P.J.; Ramalho-Santos, J.. "Mitochondrial bioenergetics of testicular cells from the domestic cat (Felis catus)-A model for endangered species". Reproductive Toxicology 27 2 (2009): 111-116. http://www.scopus.com/inward/record.url?eid=2-s2.0-62549148154&partnerID=MN8TOARS. 10.1016/j.reprotox.2009.01.008 Gaspar-Maia, A.; Alajem, A.; Polesso, F.; Sridharan, R.; Mason, M.J.; Heidersbach, A.; Ramalho-Santos, J.; et al. "Chd1 regulates open chromatin and pluripotency of embryonic stem cells". Nature 460 7257 (2009): 863-868. http://www.scopus.com/inward/record.url?eid=2-s2.0-68949164755&partnerID=MN8TOARS. 10.1038/nature08212 Sousa, A.P.M.; Tavares, R.S.; Velez De La Calle, J.F.; Figueiredo, H.; Almeida, V.; Almeida-Santos, T.; Ramalho-Santos, J.. "Dual use of Diff-Quik-like stains for the simultaneous evaluation of human sperm morphology and chromatin status". Human Reproduction 24 1 (2009): 28-36. http://www.scopus.com/inward/record.url?eid=2-s2.0-57749183247&partnerID=MN8TOARS. 10.1093/humrep/den365 Amaral, S.; Mota, P.C.; Lacerda, B.; Alves, M.; Pereira, M.d.L.; Oliveira, P.J.; Ramalho-Santos, J.. "Testicular mitochondrial alterations in untreated streptozotocin-induced diabetic rats". Mitochondrion 9 1 (2009): 41-50. http://www.scopus.com/inward/record.url?eid=2-s2.0-60249101037&partnerID=MN8TOARS. 10.1016/j.mito.2008.11.005 Gamboa, S.; Machado-Faria, M.; Ramalho-Santos, J.. "Seminal traits, suitability for semen preservation and fertility in the native Portuguese horse breeds Puro Sangue Lusitano and Sorraia: Implications for stallion classification and assisted reproduction". Animal Reproduction Science 113 1-4 (2009): 102-113. http://www.scopus.com/inward/record.url?eid=2-s2.0-64949167954&partnerID=MN8TOARS. 10.1016/j.anireprosci.2008.06.004 Baptista, M.; Ramalho-Santos, J.. "Spermicides, microbicides and antiviral agents: Recent advances in the development of novel multi-functional compounds". Mini-Reviews in Medicinal Chemistry 9 13 (2009): 1556-1567. http://www.scopus.com/inward/record.url?eid=2-s2.0-75449084546&partnerID=MN8TOARS. 10.2174/138955709790361548 Ramalho-Santos, J.. "Manifesto". Nature 458 7239 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-64749113002&partnerID=MN8TOARS. 10.1038/458796a Vieira, O.V.; Hartmann, D.O.; Cardoso, C.M.P.; Oberdoerfer, D.; Baptista, M.; Santos, M.A.S.; Almeida, L.; Ramalho-Santos, J.; Vaz, W.L.C.. "Surfactants as microbicides and contraceptive agents: A systematic In Vitro study". PLoS ONE 3 8 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-51449104764&partnerID=MN8TOARS. 10.1371/journal.pone.0002913 Amaral, S.; Mota, P.; Rodrigues, A.S.; Martins, L.; Oliveira, P.J.; Ramalho-Santos, J.. "Testicular aging involves mitochondrial dysfunction as well as an increase in UCP2 levels and proton leak". FEBS Letters 582 30 (2008): 4191-4196. http://www.scopus.com/inward/record.url?eid=2-s2.0-57649108974&partnerID=MN8TOARS. 10.1016/j.febslet.2008.11.020 Amaral, S.; Oliveira, P.J.; Ramalho-Santos, J.. "Diabetes and the impairment of reproductive function: Possible role of mitochondria and reactive oxygen species". Current Diabetes Reviews 4 1 (2008): 46-54. http://www.scopus.com/inward/record.url?eid=2-s2.0-38949101210&partnerID=MN8TOARS. 10.2174/157339908783502398 Sánchez-Partida, L.G.; Simerly, C.R.; Ramalho-Santos, J.. "Freeze-dried primate sperm retains early reproductive potential after intracytoplasmic sperm injection". Fertility and Sterility 89 3 (2008): 742-745. http://www.scopus.com/inward/record.url?eid=2-s2.0-40249111674&partnerID=MN8TOARS. 10.1016/j.fertnstert.2007.02.066 Morte, M.I.; Rodrigues, A.M.; Soares, D.; Rodrigues, A.S.; Gamboa, S.; Ramalho-Santos, J.. "The quantification of lipid and protein oxidation in stallion spermatozoa and seminal plasma: Seasonal distinctions and correlations with DNA strand breaks, classical seminal parameters and stallion fertility". Animal Reproduction Science 106 1-2 (2008): 36-47. http://www.scopus.com/inward/record.url?eid=2-s2.0-41549114579&partnerID=MN8TOARS. 10.1016/j.anireprosci.2007.03.020 RamalhoSantos, João. "Adição de piruvato de sódio e trolox ao diluidor utilizado para congelação de sêmen de garanhões férteis e subférteis". (2008): 10.1590/s0103-84782008000800028 Varum, S.; Bento, C.; Sousa, A.P.M.; Gomes-Santos, C.S.S.; Henriques, P.; Almeida-Santos, T.; Teodósio, C.; Paiva, A.; Ramalho-Santos, J.. "Characterization of human sperm populations using conventional parameters, surface ubiquitination, and apoptotic markers". Fertility and Sterility 87 3 (2007): 572-583. http://www.scopus.com/inward/record.url?eid=2-s2.0-33847717131&partnerID=MN8TOARS. 10.1016/j.fertnstert.2006.07.1528 Amaral, A.; Ramalho-Santos, J.; St John, J.C.. "The expression of polymerase gamma and mitochondrial transcription factor A and the regulation of mitochondrial DNA content in mature human sperm". Human Reproduction 22 6 (2007): 1585-1596. http://www.scopus.com/inward/record.url?eid=2-s2.0-34447303791&partnerID=MN8TOARS. 10.1093/humrep/dem030 St John JC; Amaral A; Bowles E; Oliveira JF; Lloyd R; Freitas M; Gray HL; et al. "The analysis of mitochondria and mitochondrial DNA in human embryonic stem cells.". Methods in molecular biology (Clifton, N.J.) 331 (2006): 347-374. http://europepmc.org/abstract/med/16881526. 10.1385/1-59745-046-4:347 Oliveira, H.; Loureiro, J.; Filipe, L.; Santos, C.; Ramalho-Santos, J.; Sousa, M.; Pereira, M.d.L.. "Flow cytometry evaluation of lead and cadmium effects on mouse spermatogenesis". Reproductive Toxicology 22 3 (2006): 529-535. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748415574&partnerID=MN8TOARS. 10.1016/j.reprotox.2006.03.009 Oliveira, H.; Santos, T.M.; Ramalho-Santos, J.; Pereira, M.D.L.. "Histopathological effects of hexavalent chromium in mouse kidney". Bulletin of Environmental Contamination and Toxicology 76 6 (2006): 977-983. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746198760&partnerID=MN8TOARS. 10.1007/s00128-006-1014-y Mota, P.C.; Ramalho-Santos, J.. "Comparison between different markers for sperm quality in the cat: Diff-Quik as a simple optical technique to assess changes in the DNA of feline epididymal sperm". Theriogenology 65 7 (2006): 1360-1375. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644987545&partnerID=MN8TOARS. 10.1016/j.theriogenology.2005.08.016 Amaral, S.; Moreno, A.J.; Santos, M.S.; Seiça, R.; Ramalho-Santos, J.. "Effects of hyperglycemia on sperm and testicular cells of Goto-Kakizaki and streptozotocin-treated rat models for diabetes". Theriogenology 66 9 (2006): 2056-2067. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845991476&partnerID=MN8TOARS. 10.1016/j.theriogenology.2006.06.006 Lloyd, R.E.; Lee, J.-H.; Alberio, R.; Bowles, E.J.; Ramalho-Santos, J.; Campbell, K.H.S.; St. John, J.C.. "Aberrant nucleo-cytoplasmic cross-talk results in donor cell mtDNA persistence in cloned embryos". Genetics 172 4 (2006): 2515-2527. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646166134&partnerID=MN8TOARS. 10.1534/genetics.105.055145 Sousa, A.P.M.; Gomes-Santos, C.S.S.; Ramalho-Santos, J.. "Localization of SNAREs., NSF and Caveolin 1 in human spermatozoa: Relationship with seminal parameters". Systems Biology in Reproductive Medicine 52 5 (2006): 347-353. http://www.scopus.com/inward/record.url?eid=2-s2.0-79961202390&partnerID=MN8TOARS. 10.1080/01485010600667050 St. John, J.C.; Ramalho-Santos, J.; Gray, H.L.; Petrosko, P.; Rawe, V.Y.; Navara, C.S.; Simerly, C.R.; Schatten, G.P.. "The expression of mitochondrial DNA transcription factors during early cardiomyocyte in vitro differentiation from human embryonic stemn cells". Cloning and Stem Cells 7 3 (2005): 141-153. http://www.scopus.com/inward/record.url?eid=2-s2.0-27744563079&partnerID=MN8TOARS. 10.1089/clo.2005.7.141 Gamboa, S.; Ramalho-Santos, J.. "SNARE proteins and caveolin-1 in stallion spermatozoa: Possible implications for fertility". Theriogenology 64 2 (2005): 275-291. http://www.scopus.com/inward/record.url?eid=2-s2.0-20444385146&partnerID=MN8TOARS. 10.1016/j.theriogenology.2004.11.021 Ramalho-Santos J; Pedroso De Lima MC; Ramalho-Santos, J.; Pedroso De Lima, M.C.. "The role of target membrane sialic acid residues in the fusion activity of the influenza virus: the effect of two types of ganglioside on the kinetics of membrane merging.". Cellular and Molecular Biology Letters 9 2 (2004): 337-351. http://europepmc.org/abstract/med/15213813. Rawe, V.Y.; Ramalho-Santos, J.; Payne, C.; Chemes, H.E.; Schatten, G.. "WAVE1, an A-kinase anchoring protein, during mammalian spermatogenesis". Human Reproduction 19 11 (2004): 2594-2604. http://www.scopus.com/inward/record.url?eid=2-s2.0-8344247662&partnerID=MN8TOARS. 10.1093/humrep/deh513 Ramalho-Santos, J.; Schatten, G.. "Presence of N-ethyl maleimide sensitive factor (NSF) on the acrosome of mammalian sperm". Systems Biology in Reproductive Medicine 50 3 (2004): 163-168. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052450745&partnerID=MN8TOARS. 10.1080/01485010490425502 Ramalho-Santos, J.; Amaral, A.; Brito, R.; Freitas, M.; Almeida Santos, T.. "Simultaneous analysis of cytoskeletal patterns and chromosome positioning in human fertilization failures". Fertility and Sterility 82 6 (2004): 1654-1659. http://www.scopus.com/inward/record.url?eid=2-s2.0-10044250251&partnerID=MN8TOARS. 10.1016/j.fertnstert.2004.05.086 Graça, A.; Ramalho-Santos, J.; Pereira, M.deL.. "Effect of lead chloride on spermatogenesis and sperm parameters in mice". Asian Journal of Andrology 6 3 (2004): 237-241. http://www.scopus.com/inward/record.url?eid=2-s2.0-4444312893&partnerID=MN8TOARS. Ramalho-Santos, J.. "Let the tub drain [2]". Scientist 17 13 (2003): http://www.scopus.com/inward/record.url?eid=2-s2.0-0037960792&partnerID=MN8TOARS. Thompson, W.E.; Ramalho-Santos, J.; Sutovsky, P.. "Ubiquitination of prohibitin in mammalian sperm mitochondria: Possible roles in the regulation of mitochondrial inheritance and sperm quality control". Biology of Reproduction 69 1 (2003): 254-260. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037774827&partnerID=MN8TOARS. 10.1095/biolreprod.102.010975 Payne, C.; St. John, J.C.; Ramalho-Santos, J.; Schatten, G.. "LIS1 Association with Dynactin is Required for Nuclear Motility and Genomic Union in the Fertilized Mammalian Oocyte". Cell Motility and the Cytoskeleton 56 4 (2003): 245-251. http://www.scopus.com/inward/record.url?eid=2-s2.0-0344420336&partnerID=MN8TOARS. 10.1002/cm.10151 Payne, C.; Rawe, V.; Ramalho-Santos, J.; Simerly, C.; Schatten, G.. "Preferentially localized dynein and perinuclear dynactin associate with nuclear pore complex proteins to mediate genomic union during mammalian fertilization". Journal of Cell Science 116 23 (2003): 4727-4738. http://www.scopus.com/inward/record.url?eid=2-s2.0-0345375736&partnerID=MN8TOARS. 10.1242/jcs.00784 Ramalho-Santos, J.; Terada, Y.; Schatten, G.. "VAMP/synaptobrevin as an acrosomal marker for human sperm". Fertility and Sterility 77 1 (2002): 159-161. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036153409&partnerID=MN8TOARS. 10.1016/S0015-0282(01)02957-0 Moreno, R.D.; Schatten, G.; Ramalho-Santos, J.. "Golgi apparatus dynamics during mouse oocyte in vitro maturation: Effect of the membrane trafficking inhibitor brefeldin A". Biology of Reproduction 66 5 (2002): 1259-1266. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036240029&partnerID=MN8TOARS. Cooper, T.G.; Yeung, C.-H.; Jones, R.; Orgein-Crist, M.-C.; Robaire, B.; Sutovsky, P.; Moreno, R.D.; et al. "Rebuttal of a role for the epididymis in sperm quality control by phagocytosis of defective sperm (multiple letters)". Journal of Cell Science 115 1 (2002): 5-7. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036153319&partnerID=MN8TOARS. Ramalho-Santos, J.; Schatten, G.; Moreno, R.D.. "Control of membrane fusion during spermiogenesis and the acrosome reaction". Biology of Reproduction 67 4 (2002): 1043-1051. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036786058&partnerID=MN8TOARS. RamalhoSantos, João. "Fluorescent probes for monitoring virus fusion kinetics: comparative evaluation of reliability". (2002): 10.1016/s0005-2736(01)00457-6 Nunes-Correia, I.; Eulálio, A.; Nir, S.; Düzgünes, N.; Ramalho-Santos, J.; Pedroso De Lima, M.C.. "Fluorescent probes for monitoring virus fusion kinetics: Comparative evaluation of reliability". Biochimica et Biophysica Acta - Biomembranes 1561 1 (2002): 65-75. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037133738&partnerID=MN8TOARS. 10.1016/S0005-2736(01)00457-6 Ramalho-Santos, J.; Moreno, R.D.; Wessel, G.M.; Chan, E.K.L.; Schatten, G.. "Membrane trafficking machinery components associated with the mammalian acrosome during spermiogenesis". Experimental Cell Research 267 1 (2001): 45-60. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035398602&partnerID=MN8TOARS. 10.1006/excr.2000.5119 Ramalho-Santos, J.; Moreno, R.D.. "Targeting and fusion proteins during mammalian spermiogenesis". Biological Research 34 2 (2001): 147-152. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034785031&partnerID=MN8TOARS. Ramalho-Santos, J.; Pedroso De Lima, M.C.. "Fusion and infection of influenza and sendai viruses as modulated by dextran sulfate: A comparative study". Bioscience Reports 21 3 (2001): 293-304. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035721635&partnerID=MN8TOARS. 10.1023/A:1013282015121 Sutovsky, P.; Moreno, R.; Ramalho-Santos, J.; Dominko, T.; Thompson, W.E.; Schatten, G.. "A putative, ubiquitin-dependent mechanism for the recognition and elimination of defective spermatozoa in the mammalian epididymis". Journal of Cell Science 114 9 (2001): 1665-1675. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035012044&partnerID=MN8TOARS. RamalhoSantos, João. "Acrosome components after intracytoplasmic sperm injection: the decondensation frontier". (2001): 10.1016/s0015-0282(01)01835-0 Ramalho-Santos, J.; Simerly, C.R.; Hewitson, L.; Schatten, G.. "Acrosome components after intracytoplasmic sperm injection: The decondensation frontier". Fertility and Sterility 76 1 (2001): 196-197. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034957422&partnerID=MN8TOARS. 10.1016/S0015-0282(01)01835-0 Chan, A.W.S.; Luetjens, C.M.; Dominko, T.; Ramalho-Santos, J.; Simerly, C.R.; Hewitson, L.; Schatten, G.. "Foreign DNA transmission by ICSI: Injection of spermatozoa bound with exogenous DNA results in embryonic GFP expression and live rhesus monkey births". Molecular Human Reproduction 6 1 (2000): 26-33. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033982494&partnerID=MN8TOARS. Ramalho-Santos, J.; Sutovsky, P.; Simerly, C.; Oko, R.; Wessel, G.M.; Hewitson, L.; Schatten, G.. "ICSI choreography: Fate of sperm structures after monospermic rhesus ICSI and first cell cycle implications". Human Reproduction 15 12 (2000): 2610-2620. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034534984&partnerID=MN8TOARS. Moreno, R.D.; Ramalho-Santos, J.; Sutovsky, P.; Chan, E.K.L.; Schatten, G.. "Vesicular traffic and Golgi apparatus dynamics during mammalian spermatogenesis: Implications for acrosome architecture". Biology of Reproduction 63 1 (2000): 89-98. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033944267&partnerID=MN8TOARS. Chan, A.W.S.; Luetjens, C.M.; Dominko, T.; Ramalho-Santos, J.; Simerly, C.R.; Hewitson, L.; Schatten, G.. "TransgenICSI reviewed: Foreign DNA transmission by intracytoplasmic sperm injection in rhesus monkey". Molecular Reproduction and Development 56 2 SUPPL. (2000): 325-328. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034026568&partnerID=MN8TOARS. Sutovsky, P.; Moreno, R.D.; Ramalho-Santos, J.; Dominko, T.; Simerly, C.; Schatten, G.. "Ubiquitinated sperm mitochondria, selective proteolysis, and the regulation of mitochondrial inheritance in mammalian embryos". Biology of Reproduction 63 2 (2000): 582-590. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033883489&partnerID=MN8TOARS. Ramalho-Santos, J.; Moreno, R.D.; Sutovsky, P.; Chan, A.W.-S.; Hewitson, L.; Wessel, G.M.; Simerly, C.R.; Schatten, G.. "SNAREs in mammalian sperm: Possible implications for fertilization". Developmental Biology 223 1 (2000): 54-69. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034235393&partnerID=MN8TOARS. 10.1006/dbio.2000.9745 Moreno, R.D.; Ramalho-Santos, J.; Chan, E.K.L.; Wessel, G.M.; Schatten, G.. "The Golgi apparatus segregates from the lysosomal/acrosomal vesicle during rhesus spermiogenesis: Structural alterations". Developmental Biology 219 2 (2000): 334-349. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034643141&partnerID=MN8TOARS. 10.1006/dbio.2000.9606 Sutovsky, P.; Moreno, R.D.; Ramalho-Santos, J.; Dominko, T.; Simerly, C.; Schatten, G.. "Ubiquitin tag for sperm mitochondria". Nature 402 6760 (1999): 371-372. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033604547&partnerID=MN8TOARS. 10.1038/46466 Hewitson, L.; Dominko, T.; Takahashi, D.; Martinovich, C.; Ramalho-Santos, J.; Sutovsky, P.; Fanton, J.; et al. "Unique checkpoints during the first cell cycle of fertilization after intracytoplasmic sperm injection in rhesus monkeys". Nature Medicine 5 4 (1999): 431-433. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032957381&partnerID=MN8TOARS. 10.1038/7430 Dominko, T.; Ramalho-Santos, J.; Chan, A.; Moreno, R.D.; Luetjens, C.M.; Simerly, C.; Hewitson, L.; et al. "Optimization strategies for production of mammalian embryos by nuclear transfer". Cloning and Stem Cells 1 3 (1999): 143-152. http://www.scopus.com/inward/record.url?eid=2-s2.0-0012759017&partnerID=MN8TOARS. Nunes-Correia, I.; Ramalho-Santos, J.; Nir, S.; Pedroso De Lima, M.C.. "Interactions of influenza virus with cultured cells: Detailed kinetic modeling of binding and endocytosis". Biochemistry 38 3 (1999): 1095-1101. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033579938&partnerID=MN8TOARS. 10.1021/bi9812524 Sutovsky, P.; Ramalho-Santos, J.; Moreno, R.D.; Oko, R.; Hewitson, L.; Schatten, G.. "On-stage selection of single round spermatids using a vital, mitochondrion-specific fluorescent probe MitoTracker(TM) and high resolution differential interference contrast microscopy". Human Reproduction 14 9 (1999): 2301-2312. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032850898&partnerID=MN8TOARS. 10.1093/humrep/14.9.2301 RamalhoSantos, João; Ramalho-Santos, J.; Pedroso De Lima, M.C.. "Role of a transbilayer pH gradient in the membrane fusion activity of the influenza virus hemagglutinin: Use of the R18 assay to monitor membrane merging". Biological Procedures Online 1 3 (1999): 107-113. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750619807&partnerID=MN8TOARS. 10.1251/bpo13 Nunes-Correia, I.; Ramalho-Santos, J.; Pedroso De Lima, M.C.. "Sendai virus fusion activity as modulated by target membrane components". Bioscience Reports 18 2 (1998): 59-68. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031727161&partnerID=MN8TOARS. 10.1023/A:1020180109275 Ramalho-Santos, J.; De Lima, M.C.P.; Almeida, M.T.; De Pedroso Lima, M.C.. "The influenza virus hemagglutinin: A model protein in the study of membrane fusion". Biochimica et Biophysica Acta - Reviews on Biomembranes 1376 1 (1998): 147-154. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032578032&partnerID=MN8TOARS. 10.1016/S0304-4157(98)00002-1 Ramalho-Santos, J.; Pedroso De Lima, M.C.. "Fusion activity of the influenza virus hemagglutinin does not require a transbilayer pH gradient". Biochimica et Biophysica Acta - Biomembranes 1330 2 (1997): 194-198. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030778514&partnerID=MN8TOARS. 10.1016/S0005-2736(97)00166-1 Almeida, M.T.; Ramalho-Santos, J.; Oliveira, C.R.; Pedroso De Lima, M.C.. "Evidence that synaptobrevin is involved in fusion between synaptic vesicles and synaptic plasma membrane vesicles". Biochemical and Biophysical Research Communications 236 1 (1997): 184-188. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031561140&partnerID=MN8TOARS. 10.1006/bbrc.1997.6928 Ramalho-Santos, J.; De Pedroso Lima, M.C.; Nir, S.. "Partial fusion activity of influenza virus toward liposomes and erythrocyte ghosts is distinct from viral inactivation". Journal of Biological Chemistry 271 39 (1996): 23902-23906. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029842067&partnerID=MN8TOARS. 10.1074/jbc.271.39.23902 Bernardes, C.; Valdeira, M.L.; Ramalho-Santos, J.; De Lima, M.C.P.. "Fusion activity of African swine fever virus towards target membranes: Lipid dependence and effect of dehydrating agents". Biochemistry and Molecular Biology International 37 3 (1995): 481-488. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029555561&partnerID=MN8TOARS. Pedroso de Lima, M.C.; Ramalho-Santos, J.; Flasher, D.; Slepushkin, V.A.; Nir, S.; Düzgunes, N.. "Target cell membrane sialic acid modulates both binding and fusion activity of influenza virus". BBA - Biomembranes 1236 2 (1995): 323-330. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029026187&partnerID=MN8TOARS. 10.1016/0005-2736(95)00067-D Almeida, M.T.; Ramalho-Santos, J.; Oliveira, C.R.; Pedroso de Lima, M.C.. "Parameters affecting fusion between liposomes and synaptosomes. Role of proteins, lipid peroxidation, pH and temperature". The Journal of Membrane Biology 142 2 (1994): 217-222. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027993101&partnerID=MN8TOARS. 10.1007/BF00234943 Ramalho-Santos, J.; Negrão, R.; Lima, M.d.C.P.d.. "Role of hydrophobic interactions in the fusion activity of influenza and sendai viruses towards model membranes". Bioscience Reports 14 1 (1994): 15-24. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028243606&partnerID=MN8TOARS. 10.1007/BF01901634 Ramalho-Santos, J.; Negrao, R.; Da Conceicao Pedroso de Lima, M.. "Fusion of Sendai virus with model membranes as affected by dehydrating agents and pH: Correlation between viral envelope hydrophobicity and fusion activity". Biochemistry and Molecular Biology International 32 6 (1994): 1121-1127. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028352917&partnerID=MN8TOARS. Ramalho-Santos, J.; Nir, S.; Düzgünes, N.; De Carvalho, A.P.; De Lima, M.D.C.P.. "A common mechanism for influenza virus fusion activity and inactivation". Biochemistry 32 11 (1993): 2771-2779. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027417786&partnerID=MN8TOARS. 10.1021/bi00062a006 PEDROSO DE LIMA, Maria da Conceicao; RAMALHO-SANTOS, Joao; MARTINS, Maria de Fatima; PATO DE CARVALHO, Arselio; BAIROS, Vasco; NIR, Shlomo. "Kinetic modeling of Sendai virus fusion with PC-12 cells. Effect of pH and temperature on fusion and viral inactivation". European Journal of Biochemistry 205 1 (1992): 181-186. http://dx.doi.org/10.1111/j.1432-1033.1992.tb16766.x. 10.1111/j.1432-1033.1992.tb16766.x Seppen, J.; Ramalho-Santos, J.; de Carvalho, A.P.; ter Beest, M.; Kok, J.W.; Pedroso de Lima, M.C.; Hoekstra, D.. "Interaction of clathrin with large unilamellar phospholipid vesicles at neutral pH. Lipid dependence and protein penetration". BBA - Biomembranes 1106 1 (1992): 209-215. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026587918&partnerID=MN8TOARS. 10.1016/0005-2736(92)90240-M

Other

Other output

From Oocytes and Pluripotent Stem Cells to Fully Differentiated Fates: (Also) a Mitochondrial Odyssey. Mitochondrial DNA, Mitochondria, Disease and Stem Cells. 2013. Ramalho-Santos, JoÃ£o; Rodrigues, Ana Sofia. http://dx.doi.org/10.1007/978-1-62703-101-1_4.
10.1007/978-1-62703-101-1_4
Level of Glycolyzable Substrates in Stallion Semen: Effect of Ejaculation Frequency on Sperm Survival after Cool Storage during the Nonbreeding Season. 2011. Gamboa S; Francisco M; Gomes P; Mendes C; Machado-Faria M; Ramalho-Santos J. http://europepmc.org/abstract/AGR/IND44569660.
10.1016/j.jevs.2010.12.011
Entry of Enveloped Viruses Into Host Cells: Fusion Activity of the Influenza Virus Hemagglutinin. Trafficking of Intracellular Membranes:. 1995. Pedroso de Lima, Maria C.; Ramalho-Santos, JoÃ£o; DÃ¼zgÃ¼nes, Nejat; Flasher, Diana; Nir, Shlomo. http://dx.doi.org/10.1007/978-3-642-79547-3_8.
10.1007/978-3-642-79547-3_8

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2019	Stem Cells and Cell Therapies: From Bench to Bedside.	11th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies. (Lisbon, Portugal)
2019	Assisted Reproduction: From Basics, to Biotechnology, to Bioethics.	IMM PostDoc Meeting IMM (Portugal)
2019	Infertility and Assisted Reproduction: From Biotechnology to Bioethics.	10th ITQB NOVA PhD Students’ Meeting (Portugal)
2019	Dentro da Caixa, Fora da Caixa, Sem Caixas: Alguns desafios em abordar a Biologia das Coisas	Departamento de História e Filosofia das Ciências, Universidade de Lisboa
2019	Para além da Biologia: Sobre as carreiras que Biólogos do futuro criarão para si próprios.	Jornadas do Mar, ICBAS, Porto
2019	As Famílias do Futuro.	36ª Conferência Caminhos para a Vida
2019	Bioética para Biólogos: Porquê?	XXII Encontro Nacional dos Estudantes de Biologia (ENEB), Faro
2018	From the Search of Functional Biomarkers in Human Sperm to Oncofertility Solutions: From the Lab to the Clinic	. Jordan Frontiers in Stem Cells, Cancer and Reproduction, International Symposium and Workshop Jordan Heshemite University
2018	Sperm Metabolomics.	European Congress of Andrology European Congress of Andrology (Budapest, Hungary)
2018	Metabolism in human sperm function: from biology, to translation, to communication.	Symposium on the Preservation of Male Fertility Karolinska Institutet (Sweden)
2018	You are your Biochemistry: Metabolism as a key player in Human Fertility	Fertility 2018, Joint Annual Conference of the Association of Clinical Embryologists (ACE), the British Fertility Society (BFS) and the Society of Reproduction and Fertility (SRF), Association of Clinical Embryologists (ACE), the British Fertility Society (BFS) and the Society of Reproduction and Fertility (SRF) (Liverpool, United Kingdom)
2018	Epigenetics as a Driver of Developmental Origins of Health and Disease	CMIN Sumit’18- Developmental Origins of Health and Disease
2018	Metabolism-based Biomarkers in Male Reproductive Function: From Function, to Translation, to Communication.	. Seminars on Biomarkers and Assay Development, Faculdade de Farmácia, Universidade de Lisboa
2017	The Multilayered Challenges of Contemporary Graduate Training in Biochemistry and Experimental Biology.	Annual Meeting of the Brazilian Biochemistry Society Brazilian Biochemistry Society (Brazil)
2017	Science, Society, Ethics, Communication: Why should YOU care?	FOIE-GRAS ETN Network School: Tools and Rationale for Measuring Mitochondrial Function in Intact Cells and Isolated Mitochondria CNC (Portugal)
2017	Metabolic Regulation of Stem Cell Pluripotency	FEBS Advanced Course on Oncometabolism (Portugal)
2017	Non-genomic effects of EDCs on sperm.	International Congress of Andrology. (Denmark)
2017	Mitochondrial function and Human Sperm Quality	European Society of Human Reproduction and Embryology (ESHRE) Annual Meeting European Society of Human Reproduction and Embryology (ESHRE) (Geneva, Switzerland)
2017	Non-genomic effects of Endocrine Disruptors on sperm cells.	International Workshop on Endocrine Disruptors (Copenhagen, Denmark)
2017	The Biology of Sex: Definitions, Paradigms, Borders, Misconceptions (and how to subvert it all)	Intersexualities: Crossing Bodies, Crossing Borders International Conference (Porto, Portugal)
2017	Da Clínica ao espermatozoide e à molécula... E regresso.	1ªs Jornadas Internacionias de Andrologia Reprodutiva, Gaia
2017	Disruptores Endócrinos e Fertilidade.	21º Congresso de Obstetrícia e Ginecologia, Coimbra
2017	Contagem (de)Crescente opara o futuro: Inovações potenciais em Procriação Medicamente Assistida.	1º Conferência do Observatório da Natalidade e Envelhecimento, Desafios da Natalidade: Infertilidade e Procriação Medicamente Assistida, ISEG, Lisboa
2017	Adventures in Reproduction and Stem Cells: From Metabolism to Ethics and Outreach.	Second Annual BioSAM– Biological Sciences Annual Meeting, Faculdade de Ciências da Universidade de Lisboa. Lisboa
2017	Alteração Genética em Embriões: Da Ciência à Ética (ou vice-versa?).	Jornadas de Ciências Biomédicas, Braga
2016	Probes to monitor sperm function	9th European Congress of Andrology (Rotterdam, Netherlands)
2016	Bioethics in the reproductive sciences.	9th Meeting of the International Network for Young Researchers in Male Fertility (Rennes, France)
2016	Notes on stem cell pluripotency: From metabolism to ethics and outreach	Stem Cell Symposium, Lisboa, Portugal
2016	Notes on Pluripotency: From metabolism to outreach.	V Inter-University Doctoral Programme in Ageing and Chronic Disease (PHDOC), Meeting, Coimbra
2016	Biologia da Reprodução: Algumas notas (mais ou menos) soltas.	II Ciclo de Conferências Ciências Biomédicas à Tarde, Universidade da Beira Interior, Covilhã
2016	Bioenergetic adventures in reproduction and pluripotency.	AVX Seminars, ITQB, Oeiras
2016	Aventuras em reprodução, pluripotência de células estaminais e cancro. João Ramalho-Santos.	IX Encontro Nacional dos Estudantes de Bioquímica (ENEBIOQ), Coimbra, P
2016	Sex-Ética: Reprodução com ética (mas sem sexo?)	XIX Encontro Nacional dos Estudantes de Biologia (ENEB), Coimbra,
2016	Da Bioquímica à Biologia da Reprodução e Células Estaminais, passando pela Banda Desenhada: O percurso de um Biólogo Errante.	Encontro Nacional da Ordem dos Biólogos. Évora.
2015	The challenges in the functional study of pluripotent stem cells and human sperm.	REPROTRAIN International Meeting (Barcelona, Spain)
2015	From the acrosome to mitochondria and stem cells: Adventures in Reproduction.	Frontiers in Reproduction International Symposium, Marine Biology Laboratory (United States)
2015	Mitochondria as regulators of fertility and pluripotency.	Hubrecht Institute Seminar Series Hubrecht Institute (Utrecht, Netherlands)
2015	- Monitoring mitochondrial function in challenging cells: Sperm and pluripotent stem cells.	5th World Congress of Targeting Mitochondria (Berlin, Germany)
2015	Os impactos éticos da Biotecnologia.	Encontro de Biotecnologia- Pavilhão do Conhecimento, Ciência Viva. Lisboa.
2015	Cientistas, Clínicos, Pacientes: Que tipo de expetativas num diálogo bioético	Congresso da APASD (Associação Portuguesa para a Segurança dos Doentes), Porto.
2015	Mitochondria as regulators os fertility and pluripotency.	VI Jornadas De Ciências Biomédicas, Universidade do Algarve, Faro
2015	Embriões excedentários: que destinos?	Jornadas da Sociedade Portuguesa de Medicina da Reprodução, Óbidos
2014	Sexually Transmitted infections and spermicides	14th Congress of the European Society for Contraception (Lisbon, Portugal)
2014	Mitochondrial and sperm function: From cell to organelle, and back.	26th German Congress of Andrology (Giessen, Germany)
2014	Profiling human sperm: From functional studies to omics analyses, and back again.	European Congress of Andrology (Barcelona, Spain)
2014	Ageing and Reproduction: A mitochondrial perspective	. 3rd World Congress on Reproduction, Oxidative Stress and Antioxidants (Paris, France)
2014	Mitochondria as regulators of pluripotency	Reproductive Biology Seminar Series, Northwestern University (Chicago, United States)
2014	A mitocôndria como reguladora da fertilidade e da pluripotência.	VI Jornadas de Genética e Biotecnologia, Universidade do Trás os Montes e Alto Douro, Vila Real
2014	Biologia da Reprodução: Um Biólogo entre a Investigação e a Clínica	As Ciências Biológicas para além da História Natural. Série de Seminários: A diversidade dos estudos em Biologia. Escola Superior Agrária, Instituto Politécnico de Coimbra.
2013	Stem Cell Pluripotency: Why Mitochondria Matter.	6th Meeting of the International Network of Young Researchers in Male Fertility (Barcelona, Spain)
2013	Mitochondria as Determinants of Stem Cell Differentiation	47th Annual Meeting of the European Society for Clinical Investigation (Albufeira, Portugal)
2013	Epigenética e Fertilidade.	3º Congresso CIMAGO, Atualizações em Oncologia, Coimbra
2013	A mitocôndria como reguladora da pluripotência e diferenciação de células estaminais.	VI Jornadas de Biologia, Universidade do Trás os Montes e Alto Douro, Vila Real,
2013	Células estaminais e Cancro	VI Encontro Nacional dos Estudantes de Bioquímica (ENEBIOQ), Aveiro
2013	A mitocôndria como reguladora da pluripotência e diferenciação de células estaminais.	XIV Jornadas de Biologia Aplicada, Universidade do Minho, Braga,
2012	Modulating sperm function for contraception: a multilayered challenge	12th Congress of the European Society for Contraception (Athens, Greece)
2012	Mitochondria in Reproduction & Stem Cells: Why bother?	FIR Symposium, Marine Biology Laboratory (United States)
2012	A mitocôndria como reguladora da pluripotência e diferenciação de células estaminais.	JORTEC 2012, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa,
2012	A mitocôndria como reguladora da fertilidade	American Association of Pharmaceutical Scientists (AAPS)– University of Porto Student Chapter, Porto
2012	A mitocôndria como reguladora da pluripotência e diferenciação de células estaminais.	V Encontro Nacional dos Estudantes de Bioquímica (ENEBIOQ), Coimbra
2012	A Biologia entre a Investigação Básica e a Investigação Clínica: A Reprodução enquanto caso de estudo	XV Encontro Nacional dos Estudantes de Biologia (ENEB), Coimbra
2011	Estratégias para investigar o que não pode ser investigado	TEDx Coimbra
2011	A Fisiologia do Espermatozóide: Da Biologia Celular e Bioquímica à Fisiologia	. XXVIII Jornadas de Estudos da Reprodução/Sociedade Portuguesa de Medicina da Reprodução, Monte Real
2011	Mitochondria as regulators of fertility and embryonic stem cell pluripotency	IV Jornadas Nacionais de Genética e Biotecnologia, Vila Real
2010	A mitocôndria como reguladora da fertilidade e pluripotência	I Jornadas de Ciências Biomédicas, Aveiro
2010	Metabolism as a regulator of pluripotency	Ciência 2010, Encontro com a Ciência e Tecnologia em Portugal

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2023 - 2023	Is the presence of depressive and anxiety symptoms associated with sperm quality? Co-supervisor	Bioquímica (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2022 - 2022	O papel do colesterol na fertilidade masculina / Role of cholesterol in male fertility Co-supervisor	Biologia Experimental e Biomedicina (PhD) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2022 - 2022	Exercício físico como uma estratégia antienvelhecimento para prevenir o declínio reprodutivo feminino / Exercise as an anti-aging strategy to prevent female reproductive decline Co-supervisor	Biologia Experimental e Biomedicina (PhD) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2022 - 2022	Estarão os espermatozoides deprimidos? Efeitos dos antidepressivos na fertilidade masculina / Are sperm depressed? Effects of antidepressants on male fertility Co-supervisor	Biologia Experimental e Biomedicina (PhD) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2022 - 2022	Assessment of stress and anxiety biomarkers present in the follicular fluid Co-supervisor	Bioquímica (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2022 - 2022	Preservação da fertilidade masculina - Avaliação dos dados em centro público Co-supervisor	Bioquímica (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2022 - 2022	Técnicas de Procriação Medicamente Assistida: O Contexto Laboratorial da Infertilidade Masculina Co-supervisor	Bioquímica (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2021 - 2021	Miméticos da restrição calórica como estratégias terapêuticas para reverter o envelhecimento oocitário / Caloric restriction mimetics as a therapeutic strategy to revert oocyte aging Co-supervisor	Biologia Experimental e Biomedicina (PhD) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2020 - 2020	Sperm quality in patients with infertility of unknown origin. Co-supervisor	Bioquímica (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2020 - 2020	Heavy Metal Exposure And Its Effects In Male Reproductive Health: An In Vivo And In Vitro Study Co-supervisor	Biologia Celular e Molecular (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2020 - 2020	Induction of antigen presentation in Tumor cells by Direct Cell Reprogramming Co-supervisor	Biologia Experimental e Biomedicina (PhD) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2020 - 2020	The communication of scientific knowledge with graphic narratives as a vector between science, art and society Co-supervisor	Biologia Experimental e Biomedicina (PhD) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2019 - 2019	Mushroom enriched-diets to ameliorate mitochondrial disfunction in Wilson disease Co-supervisor	Biociências (PhD) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019 - 2019	Analysis of the Efficacy and Safety of Spermicides with Benzalkonium Cholride and Myristalkonium Chloride as Active Principles Co-supervisor	Bioquímica (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019 - 2019	Evaluation of ageing-related molecular and bioenergetic alterations in bovine oocytes Supervisor	Biologia Celular e Molecular (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019 - 2019	tracing hepatic glycogen and lipid metabolism With stable isotope tracers: insigts from murine studies. Co-supervisor	Biologia Experimental e Biomedicina (PhD) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2019 - 2019	Relactionship between intesttinal Short-chain, fatty acid production intestinal permeac«bility and hepatic bioenergetic status in NAFLD Co-supervisor	Biologia Experimental e Biomedicina (PhD) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2019 - 2019	Generating antigen presenting celes by direct cellular reprogramming Co-supervisor	Biologia Experimental e Biomedicina (PhD) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2019 - 2019	Role of SP1 and PADI2 during Oligodendrocyte Differentiation Enhanced by Mechanotransduction Co-supervisor	Biologia Experimental e Biomedicina (PhD) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2019 - 2019	Elucidating the Role os Mitotic Bookmarking in Hematopoietic Stem Cells Co-supervisor	Biologia Experimental e Biomedicina (PhD) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2019 - 2019	Restoring Antitumor Immunity With Dendritic Cell Reprogramming Strategies Co-supervisor	Biologia Experimental e Biomedicina (PhD) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2018 - 2019	Analysis of the Efficacy and Safety of Benzalkonium Chloride and Myristalkonium Chloride as Active Principles for Contraceptive Purposes Co-supervisor of Maria Inês Alfaiate	Mestrado em Bioquímica (Master) Universidade de Coimbra, Portugal
2018 - 2019	Evaluation of ageing-related molecular and bioenergetic alterations in bovine oocytes Co-supervisor of Maria Moreira Soares	Mestrado em Biologia Celular e Molecular (Master) Universidade de Coimbra, Portugal
2017 - 2019	Técnicas de data mining aplicadas ao varicocele Co-supervisor of Judith Santos Pereira	Mestrado em Engenharia Informática e Sistemas (Master) Instituto Politécnico de Coimbra Instituto Superior de Engenharia de Coimbra, Portugal
2018 - 2018	Quiet! They May Be at Rest: Metabolic Regulation of Paused Pluripotency. Supervisor	Biologia Celular e Molecular (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018 - 2018	Estimulação angiogénica de tecido ovárico criopreservado Co-supervisor	Bioquímica (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018 - 2018	Comparação de parâmetros mitocondriais entre oócitos jovens e envelhecidos Co-supervisor	Biologia Celular e Molecular (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018 - 2018	The New Equine Virus (NEV): Diagnostic and Antivirals Supervisor	Biologia Experimental e Biomedicina (PhD) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2018 - 2018	Antimicrobial Peptides (AMP) and microRNA (miR) as Synergistic Therapy for Wound Healing Co-supervisor	Biologia Experimental e Biomedicina (PhD) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2017 - 2018	Quiet, they may be at rest: Molecular Mechanisms of paused pluripotency Co-supervisor of Bibiana Correia Silva	Mestrado em Biologia Celular e Molecular (Master) Universidade de Coimbra, Portugal
2017 - 2018	Comparação de parâmetros mitocondriais entre ovócitos jovens e envelhecidos Co-supervisor of Raquel Direito Fernandes	Mestrado em Biologia Celular e Molecular (Master) Universidade de Coimbra, Portugal
2017 - 2018	Estimulação angiogénica de tecido ovárico criopreservado Co-supervisor of Maria Carolina Pereira Reis	Mestrado em Bioquímica (Master) Universidade de Coimbra, Portugal
2017 - 2017	Analysis of metabolic heterogeneity over cell division cycle in non-synchronized yeast - a 13C based experimental-computational approach Co-supervisor	Biociências (PhD) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2017 - 2017	Dissecting the Mechanisms Governing Skin Wound Healing Induced by na Umbilical Cord Blood-Derived Product Co-supervisor	Biologia Experimental e Biomedicina (PhD) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2017 - 2017	"Targeted molecules to assess and improve human sperm quality: a mitochondrial perspective" / "Uso de moléculas direcionadas para a mitocôndria para avaliar e melhorar a qualidade espermática" Supervisor	Biologia Experimental e Biomedicina (PhD) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2017 - 2017	Edible mushrooms as mediators of sustainability and human health Co-supervisor	Biodiversidade e Biotecnologia Vegetal (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2012 - 2017	Framing pluripotency: From gene to image Supervisor	Cell, Molecular and Developmental Biology (PhD) Universidade de Coimbra, Portugal
2012 - 2016	Mechanisms underlying metabolic shift in pluripotent stem cells Supervisor	Cell, Molecular and Developmeent Biology (PhD) Universidade de Coimbra, Portugal
2015 - 2015	Mechanisms and possible function of SIRT3 in mESC Supervisor	Bioquímica (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2010 - 2015	Human sperm motility: Proteins and metabolites towards the same journey’s end Co-supervisor	Biologia Experimental e Biomedicina (PhD) Universidade de Coimbra, Portugal
2014 - 2014	Dieta rica em frutose e acumulação lipidica patológica no fígado: o papel do microbioma intestinal Co-supervisor	Biociências (PhD) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2014 - 2014	Metabolic modulation in paused-like pluripotency Supervisor	Biociências (PhD) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2014 - 2014	Preservação da fertilidade: maturação in vitro de oócitos pré ou pós vitrificação Co-supervisor	Bioquímica (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2014 - 2014	A cat problem: Characterization of feline spermatogonial stem cells Supervisor	Biologia Celular e Molecular (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2014 - 2014	Insights into the reproductive dysfunction in diabetes: an in vitro approach Co-supervisor	Biologia Celular e Molecular (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2010 - 2014	Mechanisms of induced pluripotency: The role of the Nucleosome Remodelling and Deacetylase complex Co-supervisor	Biologia Experimental e Biomedicina Universidade de Coimbra, Portugal
2013 - 2013	Estudo de subpopulações de espermatozóides com base no conteúdo em espécies reativas de oxigénio mitocondriais Supervisor	Biologia Celular e Molecular (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2008 - 2013	Metabolismo e diferenciação de células estaminais Co-supervisor	Cell Biology Universidade de Coimbra, Portugal
2012 - 2012	Desafios na Inovação da Comunicação de Ciência em Portugal Co-supervisor	Biociências (PhD) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2010 - 2010	Characterization of KIR2DS1+ decidual Natural Killer cells in healthy and viral/bacterial – infected human pregnancy Co-supervisor	Biociências (PhD) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2010 - 2010	Generation of a VASA/GDF-9/ZP3-promoter driven triple transgenic reporter mouse line as a tool to study ovarian dynamics Supervisor	Biociências (PhD) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2006 - 2010	The domestic cat as a model for endangered felids: From isolated mitochondria as a screening tool, to testis tissue xenografting for fertility recovery Supervisor	Universidade de Coimbra, Portugal
2009 - 2009	The role of metabolism and mitochondrial function in embryonic stem cells Supervisor	Biologia (PhD) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009 - 2009	A Two-Sided Tale: The Influences of Environmental Endocrine Disruptors and Sperm Chromatin Status on Male Fertility Supervisor	Biologia (PhD) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009 - 2009	Unraveling the Mechanisms of Spermicidal Activity by Surfactants:Their Potential Use as Safe Multi-Functional Compounds Supervisor	Biologia (PhD) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2008 - 2008	Regulation of Apoptosis and Differentiation by P53 in Human Embryonic Stem Cells Co-supervisor	Biologia (PhD) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2006 - 2006	Infertilidade Equina: Múltiplas Fragilidades ou um "Fado" do Espermatozóide Supervisor	Biologia (PhD) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2005 - 2005	Functional Characterisation of the Human Sperm: Implications for Fertility Supervisor	Biologia (PhD) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2004 - 2004	Mitochondria Modulate Pluripotency in Human Embryonic Stem Cells Supervisor	Biologia (PhD) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2004 - 2004	Linking Open Chromatin to Pluripotency in es Cells. the Role of the Chromatin Rewmodeler Chd1 Co-supervisor	Biologia (PhD) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2004 - 2004	A Problemática da Diabetes na Fertilidade Masculina: Meandros Histológicos, Bioquímicos e Moleculares Supervisor	Biologia (PhD) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2003 - 2003	Human Sperm Mitochondrial Function: Implications for Male (in)fertility Supervisor	Biologia (PhD) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Event organisation

	Event name Type of event (Role)	Institution / Organization
2018/05/05 - 2018/05/15	The 20th Europen Testis Workshop (ETW), Óbidos, Portugal. (2018/05/05 - 2018/05/15) Congress (President of the Organising Committee)

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2019	Andrology & Assisted Reproduction (Thesis) Main arguer	Marc Torrà (PhD) Hospital Clínic de Barcelona, Spain Universitat de Barcelona Departament de Medicina, Spain
2018	Stem cell differentiation (Thesis) Main arguer	Elsa Sousa (PhD) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018	Stem cell differentiation (Thesis) Main arguer	Teresa Silva (PhD) Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
2018	Testis Organoids (Thesis) Main arguer	João Pedro Alves-Lopes (PhD) Karolinska Institutet, Sweden
2017	Sperm physiology and Endocrine disruptors (Thesis) Main arguer	Anders Rehfeld. (PhD) University of Copenhagen Biotech Research and Innovation Centre, Denmark
2015	Stem cell differentiation (Thesis) Main arguer	Ana Freire (PhD) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2014	stem cell differentiation (Thesis) Main arguer	Joana Xavier (PhD) Universidade de Lisboa Faculdade de Farmácia, Portugal
2013	Bioethics of cloning (Thesis) Arguer	Carlos Pereira (PhD) Universidade Católica Portuguesa, Portugal

Journal scientific committee

	Journal title (ISSN)	Publisher
2019 - Current	Fertility and Sterility- Science
2019 - Current	International Journal of Molecular Sciences (1422-0067)	MDPI AG
2013 - Current	Reproduction (1741-7899)	Bioscientifica
2012 - 2017	Human Reproduction
2007 - 2010	Human Reproduction Update
2003 - 2006	Human Reproduction (1460-2350)	Oxford University Press

Distinctions

Award

2020	Prémio Santander-UC de Inovação Pedagógica Universidade de Coimbra, Portugal
2018	Prémio Mocho/Genes d’Ouro, Melhor Professor da Licenciatura em Biologia
2016	Prémio Jornal “As Beiras”, Investigação/Ciência
2015	Fronteirs in Reproduction Alumni Award