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Vera Martins is a Principal Investigator at the Instituto Gulbenkian de Ciência (IGC) since September 2015. She is recognized as a leading expert in the field of T lymphocyte and thymus development, with broad knowledge spanning from physiology to disease, including areas such as autoimmunity and leukemia. One of her groundbreaking achievements was the identification of thymic cell competition, a crucial mechanism that suppresses leukemia. Vera completed her undergraduate studies in Microbiology and Genetics at the Faculdade de Ciências - Universidade de Lisboa. She then pursued her PhD at the Max-Planck Institute for Immunobiology and Epigenetics in Freiburg, Germany, where she extensively researched early thymic progenitors, T cell lineage commitment, and central tolerance induction in the thymus. During her postdoctoral positions at the University Hospital Ulm and the German Cancer Research Center, Heidelberg, both in Germany, she gained valuable experience before establishing herself as an independent Group Leader at the IGC. Vera leads the Lymphocyte Development and Leukemogenesis Lab. Her work has challenged one of the central dogmas of thymus biology that stated that no cell in the thymus can self-renew. She was the first to describe cell competition in the thymus and demonstrated its role as a tumor suppressor in preventing leukemia. Notably, her research revealed that impaired cell competition in the thymus leads to the emergence of T cell acute lymphoblastic leukemia (T-ALL), which closely mimics the pediatric form of the disease. This valuable model allows for further investigation into leukemia initiation. Currently, Vera's team focuses on studying thymopoiesis under physiological conditions, particularly examining cell competition, and on the factors that contribute to leukemia development. In these topics, they have identified the specific cells involved in cell competition, as well as a small population that marks the initiation of leukemia. Currently, Vera’s team studies thymopoiesis in physiological conditions, with a strong focus on cell competition, and those enabling leukemia. Her team’s work has identified the cells that mediate cell competition, as well as the thymocytes that have the potential to self-renew to enable thymus autonomy. Further, they have identified a small population that marks leukemia initiation. The team's work and expertise are consolidated. She has successfully secured funding for her research, as well as her own salary, and has obtained a prestigious La Caixa Grant. As an independent group leader, she has contributed to the scientific community through the publication of peer-reviewed articles as well as writing a viewpoint article and a review. Vera has been invited to serve as a speaker and chair at various National and International Meetings, and she has also been invited to speak at renowned research institutes in Portugal, including Champalimaud, IMM, CEDOC, and Univ. Minho. Additionally, she has lectured at two IGC PhD Programs. Vera has played an active role in contributing to the academic community by serving as a referee in seven PhD theses, acting as the main referee for four of them. She has also served as an advisor in eight PhD Thesis Committees. In terms of supervision, as a Principal Investigator, Vera has mentored three postdoctoral fellows (one within her own lab), three PhD students (one within her own lab), six MSc students (one within her own lab), one BSc student, and seven BSc students engaged in voluntary internships. Furthermore, she has supervised four lab managers and six graduate lab assistants.
Identification

Personal identification

Full name
Vera Sofia Correia Martins

Citation names

  • Vera C. Martins

Author identifiers

Ciência ID
0716-1770-C9D3
ORCID iD
0000-0001-8717-9709
Google Scholar ID
https://scholar.google.com/citations?user=F2IEKG4AAAAJ&hl=en

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Immunology
  • Natural sciences - Biological Sciences - Developmental Biology

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
German Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
2007/12
Concluded
Dr. Rer. Nat. (Doktor (PhD))
Albert-Ludwigs-Universität Freiburg, Faculty of Biology, Germany

Max-Planck-Institut für Immunbiologie und Epigenetik, Germany
"Notch1 and Lymphotoxin beta receptor in lymphopoiesis" (THESIS/DISSERTATION)
2003
Concluded
Biologia Microbiana e Genética (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Genetic mapping of the homeostatic control of CD4+CD25+ splenocytes in mice" (THESIS/DISSERTATION)
Affiliation

Science

Category
Host institution
Employer
2015/09 - Current Principal Investigator (Research) Instituto Gulbenkian de Ciência, Portugal
2008/09 - 2015/08 Postdoc (Research) University Hospital of Ulm and German Cancer Research Center, Heidelberg, Germany, Germany
2008/01 - 2008/06 Postdoc (Research) Max Planck Institute for Immunobiology and Epigenetics, Germany
2004/01 - 2007/12 Research Trainee (Research) Max Planck Institute for Immunobiology and Epigenetics, Germany
Projects

Grant

Designation Funders
2022/12/31 - 2025/12/30 T cell acute lymphoblastic leukemia: Origin & Relapse
Principal investigator
Instituto Gulbenkian de Ciência, Fundação Calouste Gulbenkian, Portugal
'La Caixa' Foundation
Ongoing
2021/11/01 - 2024/10/31 Cell competition in the thymus versus Leukemia – Understanding homeostasis and disease prevention
PTDC/MED-IMU/3649/2021
Principal investigator
Instituto Gulbenkian de Ciência, Fundação Calouste Gulbenkian, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2021/11 - 2024/10 Competição Celular no Timo versus Leucemia – Compreensão da Homeostasia e Prevenção da Doença
Provided by PTCRIS: PTDC/MED-IMU/3649/2021
Fundação para a Ciência e a Tecnologia
2018/10 - 2021/09 Cell competition in the thymus
PTDC/BIA-BID/30925/2017
Fundação para a Ciência e a Tecnologia
2004/01 - 2007/12 A NOVEL IN VIVO APPROACH TO ANALYSE ORGAN-SPECIFIC STEM CELL ACTIVITY
Provided by PTCRIS: SFRH/BD/12502/2003
Fundação para a Ciência e a Tecnologia

Contract

Designation Funders
2020 - Current T Lymphocyte Development and Leukemogenesis
CEECIND/03106/2018
Principal investigator
Instituto Gulbenkian de Ciência, Fundação Calouste Gulbenkian, Portugal
Fundação para a Ciência e a Tecnologia
Outputs

Publications

Journal article
  1. Rafael A. Paiva; Camila V. Ramos; Gonçalo Leiria; Vera C. Martins. "IL-7 Receptor Drives Early T Lineage Progenitor Expansion". The Journal of Immunology (2022): https://doi.org/10.4049/jimmunol.2101046.
    10.1101/2021.10.23.465581
  2. Ricardo S. Paiva; Camila V. Ramos; Sara R. Azenha; Carolina Alves; Afonso P. Basto; Luis Graca; Vera C. Martins. "Peptidylprolyl isomerase C (Ppic) regulates invariant Natural Killer T cell (iNKT) differentiation in mice". European Journal of Immunology (2021): https://doi.org/10.1002/eji.202048924.
    10.1002/eji.202048924
  3. Camila V. Ramos; Vera C. Martins. "Cell competition in hematopoietic cells: Quality control in homeostasis and its role in leukemia". Developmental Biology (2021): https://doi.org/10.1016/j.ydbio.2021.02.013.
    10.1016/j.ydbio.2021.02.013
  4. Rafael A. Paiva; António G.G. Sousa; Camila V. Ramos; Mariana Ávila; Jingtao Lilue; Tiago Paixão; Vera C. Martins. "Self-renewal of double-negative 3 early thymocytes enables thymus autonomy but compromises the ß-selection checkpoint". Cell Reports (2021): https://doi.org/10.1016/j.celrep.2021.108967.
    10.1016/j.celrep.2021.108967
  5. Rafael A. Paiva; António G. G. Sousa; Ramos, C. V.; Mariana Ávila; Jingtao Lilue; Tiago Paixão; Vera C. Martins. "Self-renewal of double negative 3 (DN3) early thymocytes allows for thymus autonomy but compromises the ß-selection checkpoint". Cell Reports (2021):
    Accepted
  6. Ricardo S. Paiva; Ramos, C. V.; Sara R. Azenha; Carolina Alves; Afonso Silva Pinto Basto; Luís Graça; Vera C. Martins. "Peptidylprolyl Isomerase C (Ppic) is dispensable for hematopoiesis". European Journal of Immunology (2021):
    Under revision
  7. Camila V. Ramos; Luna Ballesteros-Arias; Joana G. Silva; Rafael A. Paiva; Marta F. Nogueira; Jorge Carneiro; Erida Gjini; Vera C. Martins. "Cell Competition, the Kinetics of Thymopoiesis, and Thymus Cellularity Are Regulated by Double-Negative 2 to 3 Early Thymocytes". Cell Reports (2020): https://doi.org/10.1016/j.celrep.2020.107910.
    10.1016/j.celrep.2020.107910
  8. Alves, Nuno L.; Carvalho, Agostinho; Serre, Karine; Martins, Vera C.; Saraiva, Margarida. "The Portuguese Society for Immunology (SPI): history and mission". European Journal of Immunology (2020): https://publons.com/publon/32888982/.
    10.1002/EJI.202070075
  9. Ballesteros-Arias, Luna; Silva, Joana G.; Paiva, Rafael A.; Carbonetto, Belen; Faisca, Pedro; Martins, Vera C.; Luna Ballesteros-Arias; et al. "T Cell Acute Lymphoblastic Leukemia as a Consequence of Thymus Autonomy". The Journal of Immunology 202 4 (2019): 1137-1144. https://publons.com/publon/29904042/.
    10.4049/JIMMUNOL.1801373
  10. Martins, Vera; Paiva, Rafael A.; Ramos, Camila V.; Martins, Vera C.. "Thymus autonomy as a prelude to leukemia". The FEBS Journal (2018): https://www.ncbi.nlm.nih.gov/pubmed/30187694.
    10.1111/febs.14651
  11. Krowiorz K; Ruschmann J; Lai C; Ngom M; Maetzig T; Martins V; Scheffold A; et al. "MiR-139-5p is a potent tumor suppressor in adult acute myeloid leukemia.". Blood Cancer Journal (2016): http://europepmc.org/abstract/med/27935579.
    10.1038/bcj.2016.110
  12. Rode, Immanuel; Martins, Vera C.; Kueblbeck, Guenter; Maltry, Nicole; Tessmer, Claudia; Rodewald, Hans-Reimer. "Foxn1 Protein Expression in the Developing, Aging, and Regenerating Thymus". The Journal of Immunology (2015): https://publons.com/publon/3278983/.
    10.4049/JIMMUNOL.1502010
  13. Martins, Vera C.; Busch, Katrin; Juraeva, Dilafruz; Blum, Carmen; Ludwig, Carolin; Rasche, Volker; Lasitschka, Felix; et al. "Cell competition is a tumour suppressor mechanism in the thymus". Nature 509 7501 (2014): 465-470. https://publons.com/publon/3278985/.
    10.1038/NATURE13317
  14. Luche, Herve; Rao, Tata Nageswara; Kumar, Suresh; Tasdogan, Alpaslan; Beckel, Franziska; Blum, Carmen; Martins, Vera C.; et al. "In vivo fate mapping identifies pre-TCR alpha expression as an intra- and extrathymic, but not prethymic, marker of T lymphopoiesis". Journal of Experimental Medicine 210 4 (2013): 699-714. https://publons.com/publon/3278991/.
    10.1084/JEM.20122609
  15. Martins, V.C.; Ruggiero, E.; Schlenner, S.M.; Madan, V.; Schmidt, M.; Fink, P.J.; von Kalle, C.; et al. "Thymus-autonomous T cell development in the absence of progenitor import". Journal of Experimental Medicine 209 8 (2012): 1409-1417. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866446850&partnerID=MN8TOARS.
    10.1084/jem.20120846
  16. Martins, V.C.; Boehm, T.; Bleul, C.C.. "Ltßr signaling does not regulate aire-dependent transcripts in medullary thymic epithelial cells". Journal of Immunology 181 1 (2008): 400-407. http://www.scopus.com/inward/record.url?eid=2-s2.0-47949100152&partnerID=MN8TOARS.
    10.4049/JIMMUNOL.181.1.400
  17. Benz, Claudia; Martins, Vera C.; Radtke, Freddy; Bleul, Conrad C.; Benz, C.; Martins, V.C.; Radtke, F.; Bleul, C.C.. "The stream of precursors that colonizes the thymus proceeds selectively through the early T lineage precursor stage of T cell development". Journal of Experimental Medicine 205 5 (2008): 1187-1199. https://publons.com/publon/3278992/.
    10.1084/JEM.20072168
  18. Heinzel, Kornelia; Benz, Claudia; Martins, Vera C.; Haidl, Ian D.; Bleul, Conrad C.; Heinzel, K.; Benz, C.; et al. "Bone marrow-derived hemopoietic precursors commit to the T cell lineage only after arrival in the thymic microenvironment". The Journal of Immunology 178 2 (2007): 858-868. https://publons.com/publon/3278954/.
    10.4049/JIMMUNOL.178.2.858
Activities

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2023/11/01 - Current Transferrin Receptor (Trf1) in thymopoiesis
Supervisor
MSc in Immunobiology
University of Bonn, Germany, Germany
2023/02/01 - Current Unraveling the molecular mechanisms of T-ALL initiation
Supervisor
Instituto Gulbenkian de Ciência, Fundação Calouste Gulbenkian, Portugal
2022/09/01 - 2023/12/17 Searching for the bone marrow progenitor contributing to thymopoiesis
Supervisor
Mestrado em Genética Molecular e Biomedicina
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017/01/01 - 2023/01/12 Cell competition in the thymus - Molecular Players
Supervisor
Gulbenkian PhD Program in Integrative Biology and Biomedicine (PhD)
Instituto Gulbenkian de Ciência, Fundação Calouste Gulbenkian, Portugal
2022/01/16 - 2022/06/15 Determining the role of the Transferrin Receptor 1 in T lymphocyte differentiation
Supervisor
Master 2 Immunology and Infectious Diseases (Master)
Université Toulouse III Paul Sabatier, France
2016/01/01 - 2021/12/07 Thymus Autonomy
Supervisor
Gulbenkian PhD Program in Integrative Biology and Biomedicine (PhD)
Instituto Gulbenkian de Ciência, Fundação Calouste Gulbenkian, Portugal
2019 - 2020 Investigating MHC-I and NK cells in thymus turnover
Supervisor
Biomedical Research (Master)
Faculdade de Medicina da Universidade de Coimbra, Portugal
2019 - 2020 Lineage tracing in T cell progenitors
Supervisor
Genética Molecular e Biomedicina (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017 - 2018 Thymus architecture in primary immunodeficiency and leukemogenesis
Supervisor
Engenharia Biológica
Universidade de Lisboa Instituto Superior Técnico, Portugal
2017 - 2017 Generation of a novel mouse model
Supervisor
Cellular and Molecular Biology (BSc) (Degree)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Jury of academic degree

Topic
Role
Candidate name (Type of degree)
Institution / Organization
2023/05/25 The establishment of the stromal microenvironment in the thymus and its implications for T-cell development
(Thesis) Main arguer
Ruben Gonçalo Rodrigues Pinheiro (PhD)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023/05/24 Tissue Damage Control in Autoimmune Diseases
(Thesis) Arguer
Vital Manuel da Silva Domingues (PhD)
Instituto Gulbenkian de Ciência, Fundação Calouste Gulbenkian, Portugal
2022 Determining the role of STAT1 and STAT3 transcription factors in transcriptional memory
(Thesis) Arguer
Sahar Tehrani (PhD)
Instituto Gulbenkian de Ciência, Fundação Calouste Gulbenkian, Portugal
2020 Molecular determinants of thymic development of CD8-expressing gd T cells
(Thesis) Main arguer
Marta Avelar (Master)
2019 Responses to liver damage: Macrophage plasticity in tissue recovery and dysbiotic drifts
(Thesis) Arguer
Inês Coelho (PhD)
Instituto Gulbenkian de Ciência, Portugal
2018 Environmental sensing by immune cells
(Thesis) Main arguer
Silvia Madeira (PhD)
Centro Champalimaud, Portugal

Universidade de Lisboa Faculdade de Medicina, Portugal
2017 Thymic stromal factors promoting T-cell leukemia
(Thesis) Main arguer
Marinela Ghezzo (PhD)
Universidade do Algarve, Portugal
2016 Dissecting the Cellular and Molecular Mechanisms of IL-7-mediated leukemia T-cell survival, proliferation and cell growth
(Thesis) Main arguer
Daniel S. Ribeiro (PhD)
Instituto de Medicina Molecular, Portugal

Association member

Society Organization name Role
2013/06 - Current Portuguese Society of Immunology (SPI) since 2018: Elected Member of the Board of Directors - Scientific Secretary
2013 - Current German Society of Immunology - Deutsche Gesellschaft fur Immunologie e.V. (DGfI) Member

Committee member

Activity description
Role
Institution / Organization
2018 - Current Scientific Secretary of the Board of Directors of the Portuguese Society of Immunology (SPI)
Other
Sociedade Portuguesa de Imunologia, Portugal
2016/01 - 2020/09 Ethics Committee Member. Evaluation of several projects every month that involve Animal Experimentation or Human samples/data.
Member
Instituto Gulbenkian de Ciência, Fundação Calouste Gulbenkian, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2018 - Current INTERFACE PhD Program Lecture: T and B lymphocyte Development (Doutoramento) Instituto Gulbenkian de Ciência, Fundação Calouste Gulbenkian, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Instituto de Medicina Molecular, Portugal
2016 - Current Gulbenkian PhD Program in Integrative Biology and Biomedicine Module: Immunobiology and Host Microbe Interaction (co-organizer in 2017) Lecture: T and B lymphocyte Development (Doutoramento) Instituto Gulbenkian de Ciência, Fundação Calouste Gulbenkian, Portugal
2016 - Current Gulbenkian PhD Program in Integrative Biology and Biomedicine Module: Developmental Biology (co-organizer in 2019) Lecture: Cell competition and T cell acute lymphoblastic leukemia (Doutoramento) Instituto Gulbenkian de Ciência, Fundação Calouste Gulbenkian, Portugal
2015 - 2015 MSc in Evolutionary and Developmental Biology Lecture: Animal Models in Biomedical Research MSc in Evolutionary and Developmental Biology Faculdade de Ciências da Universidade de Lisboa, Portugal
2014 - 2014 Major in Cancer Biology Lecture: Leukemogenesis German Cancer Research Center, Germany

Mentoring / Tutoring

Topic Student name
2023/06/16 - Current T cell Acute Lymphoblastic Leukemia - Origin Michelle Pereira
2019/03 - 2022 Cell competition in the thymus - analysis of knockout models for genes differentially expressed in cell competition Ricardo Paiva, Postdoc
2016 - 2018 T Cell Acute Lymphoblastic Leukemia as a Consequence of Thymus Autonomy Luna Ballesteros-Arias, Postdoc
Distinctions

Award

2013 Fritz und Ursula Melchers Award
German Society of Immunology, Germany

Other distinction

2008 Postdoctoral fellowship
Max-Planck-Gesellschaft zur Förderung der Wissenschaften, Germany
2004 PhD Fellowship
Fundação para a Ciência e a Tecnologia, Portugal