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Vera Isca graduated in Biochemistry from the University of Beira Interior (2010), has a master's degree in Organic Chemistry and Natural Products from the University of Aveiro (2013) and has a PhD degree in Pharmacy, specializing in the field of Pharmaceutical and Therapeutic Chemistry by Faculdade de Farmácia da Universidade de Lisboa and Universidade Lusófona de Lisboa (CBIOS), financed by FCT (2023). Vera Isca recently completed her PhD with the title "A New Class of Protein Kinase Modulators: From Ethnopharmacology to Nanoparticles." This study contributed to the development of more potent and selective antitumoral agents sourced from natural products. Laboratory skills in Organic Chemistry, Phytochemistry, Spectroscopic and Separation Technics. Know-how in molecular docking studies. Co-author of several international journal articles, reviews and papers with referees, co-author of a book chapter in the book: Natural Products: Research Reviews (2012). Scientific work recognized with several awards.
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Identification

Personal identification

Full name
Vera Mónica Sousa Isca

Citation names

  • Isca, Vera M. S.
  • Vera M. S. Isca
  • Vera Isca
  • Isca, V.M.S.

Author identifiers

Ciência ID
0717-D386-4960
ORCID iD
0000-0002-9045-7287
Scopus Author Id
56211512900

Email addresses

  • vera.isca@ulusofona.pt (Professional)

Addresses

  • Universidade Lusófona, Campo Grande, 376, 1749-024, Lisboa, Lisboa, Portugal (Professional)

Websites

Knowledge fields

  • Exact Sciences - Chemical Sciences - Organic Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
English Intermediate (B1) Upper intermediate (B2) Intermediate (B1) Upper intermediate (B2) Upper intermediate (B2)
Spanish; Castilian Elementary (A2) Beginner (A1) Beginner (A1) Elementary (A2) Beginner (A1)
Education
Degree Classification
2019/01/01 - 2023/10/23
Concluded
 Farmácia (Doutoramento)
Major in Especialidade: Química Farmacêutica e Terapêutica
Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal

Universidade do Porto Faculdade de Farmácia, Portugal
"New class of protein kinase C modulators: from ethnopharmacological to nanoparticles" (THESIS/DISSERTATION)
 Distinção e louvor
2013
Concluded
 Química, ramo de Química Orgânica e Produtos Naturais (Mestrado)
Universidade de Aveiro, Portugal
"Salicornia ramosissima J. Woods: Estudo fitoquímico das partes aéreas" (THESIS/DISSERTATION)
 15
2010
Concluded
 Biochemistry (Licenciatura)
Universidade da Beira Interior, Portugal
"n/a" (THESIS/DISSERTATION)
 13
Affiliation

Science

Category
Host institution 		Employer
2024/10/01 - Current Postdoc (Research) Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal
2023/12/01 - 2024/09/30 Postdoc (Research) Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal
Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal
2018/07/01 - 2018/12/31 Researcher (Research) Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal
2018/03/01 - 2018/06/30 Researcher (Research) Universidade de Lisboa Centro de Química Estrutural, Portugal
2017/07/15 - 2017/12/31 Researcher (Research) Universidade de Lisboa Centro de Química Estrutural, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2020/02/27 - Current Assistant (University Teacher) Universidade Lusófona de Humanidades e Tecnologias, Portugal
Universidade Lusófona de Humanidades e Tecnologias, Portugal
2017/09/01 - 2018/07/31 Tutor (University Teacher) Universidade Lusófona de Humanidades e Tecnologias, Portugal
Projects

Grant

Designation Funders
2024/10/01 - 2024/12/31 Bolsa de Investigação (BIPD)
UIDP/04567/2020
Post-doc Fellow
Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal
Ongoing
2023/12/01 - 2024/09/30 Bolsa de Investigação (BIPD)
UIDB/04567/2020
Post-doc Fellow
Concluded
2021 - 2024 LusoModLOX: Lusophone flora fighting disease: focus on therapeutic lysyl oxidase modulators
ILIND/F+/EI/01/2020
PhD Student Fellow
COFAC - Cooperativa de Formação e Animação Cultural CRL, Portugal
 COFAC - Cooperativa de Formação e Animação Cultural CRL
Ongoing
2019/01/01 - 2022/12/31 New class of PKC modulators: from ethnopharmacological to nanoparticles
SFRH/BD/137671/2018
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2024/01/01 - 2025/06/30 Multidrug Resistance Reversal in Cancer Through a Novel Allosteric Mechanism
OFAC/ILIND/CBIOS/2/2023
Post-doc Fellow
Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal
Ongoing
2023/09 - 2024/12 Erasmus Mundus Design Measures "Bio.Natural - Chemistry of Natural Bioactives"
ERASMUS-EDU-2023-EMJM-DESIGN, 101127246
Post-doc Fellow
European Commission
2023/01 - 2024/06 Blue4Skin - Innovative skin products from the valorization of industrial marine wastes
COFAC/ILIND/CBIOS/1/2022
PhD Student Fellow
Ongoing
2021/12 - 2022/12 Combining synergistic approaches to fight cancer (CoSysCan)
COFAC/ILIND/CBIOS/1/2021
PhD Student Fellow
2019/01/01 - 2019/12/31 Centro de Química Estrutural
UID/QUI/00100/2019
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Lisboa Centro de Química Estrutural, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Isca, Vera M. S.; Seca, Ana M. L.; Pinto, Diana C. G. A.; Silva, Artur M. S.. "An overview of Salicornia genus : the phytochemical and pharmacological profile". Portugal: Daya Publishing House,
Conference abstract
  1. Santos Filipe, Márcia; Domínguez-Martín EM; Vera M. S. Isca; Pereira, Raquel; Calhelha, Ricardo; F. Mandim; Diaz-Lanza Ana María; Barros, Lillian; Rijo, Patrícia. "P. Plectranthus aliciae: Biological activity of 6,7-dehydroroyleanone and derivatives". Paper presented in 9th International Electronic Conference on Medicinal Chemistry, 2023.
  2. Isca, Vera M. S.; Bangay, Gabrielle; Matos, Ana; Morais, João; Viana, Ana S.; Reis, Catarina; Pereira-Leite, Catarina; et al. "7a-acetoxy-6ß-hydroxyroyleanone as lead compound: from extraction optimization to hybrid nanoparticles for breast cancer therapy". Paper presented in 9th International Electronic Conference on Medicinal Chemistry, 2023.
  3. Isca, V MS; Ntungwe, E; Bangay, G; Princiotto, S; Dinic, J; Pesic, M; Saraíva, L; Afonso, C AM; Rijo, P. "Natural and semi-synthetic royleanone diterpenoids from Plectranthus spp. as potential anti-tumoral agents". 2022.
    10.1055/s-0042-1759260
  4. Gabrielle Bangay; Vera M. S. Isca; Daniel J. V. A. Dos Santos; Ricardo J. Ferreira; Salvatore Princiotto; Mirna Jovanovic; Milica Pesic; Patricia Rijo. "Royleanone Analogues from Plectranthus spp. Demonstrate P-gp Inhibition and PKC Modulation". 2022.
    10.3390/ECMC2022-13459
  5. Isca, Vera; Bangay, Gabrielle; Ferreira, Ricardo; dos Santos, Daniel; Dinic, Jelena; Pesic, Milica; Saraiva, Lucilia; Afonso, Carlos; Rijo, Patricia. "Inhibition of P-glycoprotein activity to overcome multidrug resistance in cancer with new diterpene royleanones from <em>Plectranthus</em> spp.". 2021.
    10.3390/ecmc2021-11385
  6. Epole Ntungwe N; Máté Vágvölgyi; Jaime A. S. Coelho; Isca, Vera M. S.; Lucília Saraiva; Ana María Díaz-Lanza; Attila Hunyadi; et al. "Natural Cytotoxic Diterpenoids as a Potential Source of Drug Leads for cancer Therapy". 2020.
    10.19277/bbr.17.2.246
  7. Rijo, Patrícia; Dominguez-Martin, Eva; Bangay, Gabrielle; Antão, Ana; Ntungwe, Epole; Isca, Vera; Diaz-Lanza, Ana. "Updated review of the bioactive compounds isolated from <em>Plectranthus ecklonii </em>Benth". 2020.
    10.3390/ecmc2020-07278
  8. Isca, Vera; Ntungwe, Epole; Domínguez-Martín, Eva; Coelho, Jaime; Ferreira, Ricardo; Dinic, Jelena; Pesic, Milica; et al. "Insight into P-glycoprotein activity of royleanones from <em>Plectranthus</em> spp.". 2020.
    10.3390/ecmc2020-07279
  9. Epole Ntungwe; Máté Vágvölgyie; Coelho, Jaime A. S.; Vera M. S. Isca; Lucília Saraiva; Diaz-Lanza Ana María; Attila Hunyadi; et al. "Chemical Composition and Biological Activity of Diterpenoids from Plectranthus mutabilis". Paper presented in 10.3390/ECMC2020-07290, 2020.
    10.3390/ecmc2020-07290
  10. Domínguez-Martín, Eva María; Ntungwe, Epole; Isca, Vera M. S.; Colombo, Eleonora; Pinto, Tatiana; Pacheco, Catarina; Coelho, Jaime; et al. "Self-assembly nanoparticles of 7a-acetoxy-6ß-hydroxyroyleanone isolated from <em>Plectranthus hadiensis</em>". 2020.
    10.3390/ecmc2020-07286
  11. Ntungwe, Epole; Isca, Vera M. S.; Vágvölgyie, M; Spengler, G; Hunyadi, A; Rijo, Patrícia. "Bio-guided phytochemical study of Plectranthus mutabilis Codd.". 2019.
    10.1055/s-0039-3399860
  12. Vera M. S. Isca; Ntungwe, E; Almeida, JF; Ferreira, IM; Pereira, R; Siopa, F; Almeida, J; et al. "Molecular docking as a tool to design new royleanone derivatives for colon cancer therapy based on PKC-d modulation". 2019.
    10.1055/s-0039-3399909
  13. Tavares, Joana; Ntungwe, Epole; Vera M. S. Isca; Domínguez-Martín EM; Rijo, Patrícia. "Optimization extraction study for the isolation of a bioactive diterpene from<em> </em><em>Plectranthuns ornatus</em> Codd.". 2019.
    10.3390/ecmc2019-06446
  14. Isca, Vera M. S.; Epole Ntungwe; Joana Tavares; Filipa Siopa; Lucília Saraiva; Mattia Mori; Maurizio Botta; Carlos A.M. Afonso; Rijo, Patrícia. "Design and molecular docking studies of new potential PKC-d activators based on royleanone scaffold". 2019.
    10.3390/ecmc2019-06297
  15. Epole Ntungwe N; Vera M. S. Isca; Joana Tavares; Máté Vágvölgyie; Lucília Saraíva; Spengler, Gabriella; Attila Hunyadi; Diaz-Lanza Ana María; Rijo, Patrícia. "Cytotoxic activity of coleon diterpenoids from Plectranthus mutabilis codd.". 2019.
    10.3390/ecmc2019-06323
  16. Isca, Vera M. S.; Seca, Ana M. L.; Pinto, Diana C. G. A.; Silva, Helena; Silva, Artur M. S.. "Salicornia ramosissima an edible halophyte with nutritional value and a source of a unique natural compound". 2015.
  17. Ferreira, Daniela; Isca, Vera M. S.; Seca, Ana M. L.; Pereira, M. Lourdes; Silva, Helena; Pinto, Diana C. G. A.; Silva, Artur M. S.. "Salicornia ramosissima: secondary metabolites and testicular protection induced by ethanol extract". 2013.
  18. Isca, Vera M. S.; Seca, Ana M. L.; Pinto, Diana C. G. A.; Silva, Artur M. S.; Silva, Helena. "Compounds identified on hexane and dichloromethane extracts of Salicornia ramosissima". 2012.
Conference poster
  1. Gabrielle Bangay; Vera M. S. Isca; Dinic, Jelena; Brito Palma, Bernardo; Daniel D. J. V. A. dos Santos; Díaz-Lanza, Ana M.; Eduardo de Melo; João Paulo A. Martins; Rijo, Patricia. "Investigating SAR Insights into Royleanones for P-gp Modulation". Paper presented in 28th International Electronic Conference on Synthetic Organic Chemistry, 2024.
  2. Vera M. S. Isca; Sitarek, Przemyslaw; Anna Merecz-Sadowska; Magdalena Malecka; Monika Owczarek; Joanna Wieczfinska; Zajdel, Radoslaw; et al. "In silico evaluation of semi-synthetic derivatives of 7a-acetoxy-6ß-hydroxyroyleanone for anticancer potential". Paper presented in 12th Conference on Medicinal and Aromatic Plants of Southeast European Countries (CMAPSEEC-2024), 2024.
  3. Vera M. S. Isca; Bangay, Gabrielle; Márcia Santos Filipe; André, Rebeca; Ahmed A. Hussein; Rijo, Patricia. "Plectranthus: an important source of bioactive diterpenoids for therapeutic applications". Paper presented in International Congress on Natural Products Research, 2024.
  4. Ntungwe, Epole; Roque, J. P. L.; Márcia Santos Filipe; Vera M. S. Isca; Rijo, Patricia; Claudio M. Nunes; Rui Fausto. "Application of 1,2,4-triazolium in structural modification of natural products and their biological activity studies.". Paper presented in International Congress on Natural Products Research, 2024.
  5. Vera M. S. Isca; Bangay, Gabrielle; Epole Ntungwe; Domínguez-Martín EM; André, Rebeca; Ana María Díaz-Lanza; Rijo, Patricia. "Plectranthus spp.: source of cytotoxic abietane diterpenoids promising for nanosystems in cancer therapy". Paper presented in Encontro Ciência 2024, 2024.
  6. Oluwasegun Adedokun; Tolulope Ojo; Charles Esukpa; Ogochukwu Ume; Ighodaro Igbe; Philip Obarisiagbon; Vera M. S. Isca; Nbang Femi-Oyewo; Rijo, p. "Unveiling the Uterine excitability potential of Harungana madagascariensis Lam. (Hypericaceae): Rationale of usage among traditional birth attendant in Nigeria". Paper presented in Encontro Ciência 2024, 2024.
  7. Florencia Z. Brauning; Gabrielle Bangay; Vera M. S. Isca; Ana Ramalho; Henrique Alves; Carlos A. M. Afonso; Ahmed A. Hussein; André, Vânia; Patrícia Rijo. "Synthesis and biological activity of halimane amide derivatives from Plectranthus ornatus Codd.". Paper presented in V Jornadas CBIOS, 2023.
  8. Oluwasegun Adedokun; Tolulope Ojo; Charles Esukpa; Ogochukwu Ume; Ighodaro Igbe; Philip Obarisiagbon; Chioma Ekejiuba; et al. "Paranaphthalene scaffold exhibits agonist modulatory influence on alpha subunit of PGE2-Bound EP2-GS Complex: Unveiling the mechanistic uterotonic property of Harungana madagascariensis Lam. (Hypericaceae) stem". Paper presented in V Jornadas CBIOS, 2023.
  9. Oluwasegun Adedokun; Ogochukwu Ume; Aisosa Kingley; Momoh Winifred; Kehinde Ibrahim; Vera M. S. Isca; Mahmoud Soliman; Rijo, Patrícia. "Cleomiscosin B: A potent coumarinolignoid exhibits promising antagonist inhibition of phosphodiesterase-5: Rationale of usage Paullinia pinnata L. (Sapindaceae) in the management of erectile dysfunction". Paper presented in V Jornadas CBIOS, 2023.
  10. Eduardo B. de Melo; João Paulo A. Martins; Márcia E. Borges; Bangay, Gabrielle; Vera M. S. Isca; Rijo, Patrícia. "3D-QSAR, pharmacophore modeling, and molecular docking for the identification of novel potential P-glycoprotein (P-gp) blockers". Paper presented in V Jornadas CBIOS, 2023.
  11. Vera M. S. Isca; Epole Ntungwe N; Rijo, Patrícia. "Exploring cytotoxic abietane diterpenoids from the Plectranthus spp. as promising nanosystems for cancer therapy". Paper presented in PSE Meeting 2023: Natural Drug Discovery Current Approach and Future Perspectives, 2023.
  12. Márcia Santos Filipe; Domínguez Martín, Eva María; Isca, Vera M. S.; Filipa Mandim; Ricardo C. Calhelha; Diaz-Lanza Ana María; Barros, Lillian; Rijo, Patrícia. "Biological activity of 6,7-dehydroroyleanonederivatives from Plectranthus aliciae". Paper presented in 71st International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA), 2023.
  13. Jiménez-González, V..; Domínguez-Martín EM; Vera M. S. Isca; López-Lázaro, M.; Calderón-Montaño, J.M.; Rijo, Patrícia. "Selective antitumoral activity of Thymelaea lanuginosa (Lam.) Ceballos & C. Vicioso. extract". Paper presented in III Bio.Natural- Bioactive Natural Products Research Conference, 2023.
  14. Vera M. S. Isca; Epole Ntungwe N; Afonso, Carlos A. M.; Rijo, Patrícia. "Breast Cancer Drug Discovery: From Plants to Nanosystems". Paper presented in Ciência 2023, 2023.
  15. Vera M. S. Isca; Lucilia Sarava; Afonso, Carlos A. M.; Rijo, Patrícia. "New diterpenoid derivatives from Plectranthus spp. for breast cancer therapy through protein kinase a activation". Paper presented in XIII iMed.ULisboa Postgraduate Students Meeting, 2023.
  16. Gabrielle Bangay; Vera M. S. Isca; Daniel J. V. A. Dos Santos; Mirna Jovanovic; Diaz-Lanza Ana María; Milica Pesic; Rijo, Patrícia. "Novel nanoformulations of royleanone diterpenoids from Plectranthus spp. for MDR cancers". Paper presented in Ciência 2023, 2023.
  17. Vera M. S. Isca; Bangay, Gabrielle; Santos, Daniel J.V.A; Diaz-Lanza Ana María; Afonso, Carlos A. M.; Rijo, Patrícia. "Cytotoxic semi-synthetic abietane diterpenoid for breast cancer therapy: form molecular docking to protein kinase a activation". Paper presented in XXVIII Encontro Nacional da SPQ, 2023.
  18. Luís M. T. Frija; Bruno Guerreiro; Inês Costa; Isca, Vera M. S.; Lucília Saraiva; Beatriz Neves; Mariana Magalhães; et al. "Hybrid azole conjugates as viable anticancer and antimicrobial agents: a preliminary biological evaluation". Paper presented in CQE Days 2023, 2023.
  19. Gabrielle Bangay; Vera M. S. Isca; Domínguez-Martín EM; Daniel J. V. A. Dos Santos; Diaz-Lanza Ana María; Lucília Saraiva; Afonso, Carlos A. M.; et al. "New formulations with royleanone derivatives from Plectranthus spp. to inhibit P-glycoprotein activity". Paper presented in 71st International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA), 2023.
  20. Vera M. S. Isca; Márcia Santos Filipe; Rijo, Patrícia. "Natural cytotoxic royleanones as tools for promising nanosystems". Paper presented in 6th International Symposium on Medicinal and Aromatic Plants (6th SIPAM), 2023.
  21. Vera M. S. Isca; Ana Mourato; Márcia Santos Filipe; Bangay, Gabrielle; Domínguez-Martín EM; Epole Ntungwe N; Daniel Murta; Rui Nunes; Rijo, Patrícia. "Natural cytotoxic royleanones and Hermetia illucens as promising nano-assemblies conjugated". Paper presented in International symposium on medicinal and aromatic plants- SIPAM-6, 2023.
  22. Vera M. S. Isca; Salvatore Princiotto; Afonso, Carlos A. M.; Rijo, Patrícia. "Design of diterpenoids as therapeutic agents in breast cancer through protein kinase C modulation". Paper presented in 13th iMed.ULisboa Postgraduate Students Meeting, 2022.
  23. Domínguez-Martín EM; Vera M. S. Isca; Salvatore Princiotto; Diaz-Lanza Ana María; Rijo, Patrícia. "Phytochemical study of the stems of ultrasound-assisted acetonic extract from Plectranthus hadiensis". Paper presented in 13th iMed.ULisboa Postgraduate Students Meeting, 2022.
  24. Gabrielle Bangay; Epole Ntungwe N; Domínguez-Martín EM; Salvatore Princiotto; Rosatella, Andreia; Diaz-Lanza Ana María; Rijo, Patrícia. "Self-assembly nanoparticles of bioactive compounds isolated from Plectranthus spp.". Paper presented in InnovDelivery 2022, 2022.
  25. Vera M. S. Isca; Bangay, Gabrielle; Salvatore Princiotto; Dinic, Jelena; Milica Pesic; Lucília Saraiva; Afonso, Carlos A. M.; Rijo, Patrícia. "Cytotoxic Activity of diterpenes from Plectranthus spp. for MDR cancer therapy". Paper presented in 5th Annual Meeting of CA17104 - New diagnostic and therapeutic tools against multidrug resistant tumors (STRATAGEM), 2022.
  26. Bruno Cardoso; Vera M. S. Isca; Rijo, Patrícia; Monteiro, O.C. "Study of photocatalytic and antimicrobial activity of new g-C3N4/TNW hybrid nanomaterials". Paper presented in CQE Days 2022, 2022.
  27. Gabrielle Bangay; Vera M. S. Isca; dos Santos, Daniel J. V. A.; Ricardo J. Ferreira; Jovanovic, M.; Milica Pesic; Rijo, Patrícia. "Royleanone ester derivatives from Plectranthus spp. demonstrate P-glycoprotein inhibition". Paper presented in 1st African Conference on Natural Products & Related Fields, 2022.
  28. Gabrielle Bangay; Vera M. S. Isca; Daniel J. V. A. Dos Santos; Ferreira, Ricardo J.; Mirna Jovanovic; Pesic, Milica; Rijo, Patrícia. "Royleanone ester derivatives from Plectranthus spp. as P-gp inhibitors". Paper presented in Ciência 2022, 2022.
  29. Rosatella, Andreia; Major Gonçalves, I.; Capitain Neto, C.; Vera M. S. Isca; Tira-Picos, T.M.; Afonso, Carlos A. M.. "Development of decontamination systems for Chemical Warfare Agents". Paper presented in Ciência 2022, 2022.
  30. Vera M. S. Isca; Saraiva, Lucilia; Carlos A. M. Afonso; Rijo, Patrícia. "Exploring the Reactivity of a natural diterpenoid to modulate protein kinase C isoforms". Paper presented in ACS Spring 2022, 2022.
  31. Vera M. S. Isca; Pereira, Raquel; Gabrielle Bangay; Epole Ntungwe N; Domínguez-Martín EM; Ferreira, Ricardo J.; Jelena Dinic; et al. "Inhibition of p-glycoprotein activity to overcome multidrug resistance in cancer with new diterpene royleanones from Plectranthus spp.". Paper presented in iMed.ULisboa Meeting 2021, 2021.
  32. Vera M. S. Isca; Epole Ntungwe N; Domínguez-Martín EM; Tomasz Sliwinski; Sitarek, Przemyslaw; Kowalczyk, Tomasz; Michal Bijak; Afonso, Carlos A. M.; Rijo, Patrícia. "Natural diterpenoids from Plectranthus spp. as apoptotic agents". Paper presented in In Fascination of Plants Day Event, 2021.
  33. Eva Maria Dominguez-Martin; Epole Ntungwe N; Vera M. S. Isca; Colombo, Eleonora; Jaime A.S. Coelho; Bangay, Gabrielle; Ana María Díaz-Lanza; Danielle Passarella; Rijo, Patricia. "Self-assembly nanoparticles of 7a-acetoxy-6ß-hydroxyroyleanone isolated from Plectranthus hadiensis". Paper presented in ACS Spring 2021, 2021.
  34. Vera M. S. Isca; Epole Ntungwe N; Domínguez-Martín EM; Jaime A. S. Coelho; Tomasz Sliwinski; Sitarek, Przemyslaw; Ewa Skala; et al. "Apoptosis in cancer cells induced by abietane diterpenoids from Plectranthus spp.". Paper presented in ACS Spring 2021, 2021.
  35. Epole Ntungwe N; Vera M. S. Isca; Lucilia Saraiva; Diaz-Lanza Ana María; Attila Hunyadi; Duarte, Noélia; Milica Pesic; Rijo, Patricia. "Naturally occurring diterpenoids from Plectranthus mutabilis Codd. with cytotoxic activity". Paper presented in Fascination of Plants Day Event, 2021.
  36. Eva Maria Dominguez-Martin; Epole Ntungwe N; Catarina Teodósio; Vera M. S. Isca; Gabrielle Bangay; Diaz-Lanza Ana María; Rijo, Patricia. "Initial studies on the phytochemical and antitumoral activity of Plectranthus hadiensis (Forssk.) Schweinf. Ex Sprenger aerial parts". Paper presented in Fascination of Plants Day Event, 2021.
  37. Epole Ntungwe; Vera M. S. Isca; Máté Vágvölgyi; Eva Maria Dominguez-Martin; Coelho, Jaime A. S.; Lucilia Saraiva; Ana María Díaz-Lanza; et al. "Therapeutic potential of diterpenoids obtained from Plectranthus mutabilis Codd.". Paper presented in ACS Spring 2021, 2021.
  38. Domínguez-Martín EM; Epole Ntungwe N; Catarina Teodósio; Vera M. S. Isca; Bangay, Gabrielle; Ana María Díaz-Lanza; Rijo, Patricia. "Phytochemical and antitumoral activity studies of Plectranthus hadiensis (Forssk.) Schweinf. ex Sprenger aerial parts". Paper presented in Proceedings of the VI Congreso de Señalización Celular, SECUAH 2021, 2021.
  39. Eva Maria Dominguez-Martin; Catarina Teodosio; Epole Ntungwe; Vera M. S. Isca; Gabrielle Bangay; Ana María Díaz-Lanza; Rijo, Patricia. "Phytochemical and antitumoral activity studies of Plectranthus hadiensis (Forssk.) Schweinf. ex Sprenger aerial parts". Paper presented in Natural Products in Cancer Research Virtual Meeting, 2021.
  40. Gabrielle Bangay; Eva Maria Dominguez-Martin; Ana Margarida Antão; Epole Ntungwe; Vera M. S. Isca; Diaz-Lanza Ana María; Rijo, Patricia. "Overview of the Bioactivity of Abietane Diterpenes from Plectranthus ecklonii Benth.". Paper presented in Natural Products in Cancer Research Virtual Meeting, 2021.
  41. Vera M. S. Isca; Catarina Garcia; Catarina P. Reis; Milica Pesic; Lucilia Saraiva; Afonso, Carlos A. M.; Rijo, Patrícia. "Innovative nanosystems with natural cytotoxic royleanone diterpenes from Plectranthus spp.". Paper presented in COST Action 17104 (STRATAGEM) WG2 Meeting and International Online Symposium on “Synthesis and nanodelivery strategies for new therapeutic tools against Multidrug Resistant Tumours”- Online event, 2020.
  42. Eva María Domínguez-Martín; Ana Margarida Antão; Epole Ntungwe; Raquel Coimbra; Vera M. S. Isca; Ana María Díaz-Lanza; Rijo, Patricia. "Phytochemical and pharmacological study of Plectranthus ecklonii Benth.". Paper presented in 1st International Electronic Conference on Biomolecules: Natural and Bio-Inspired Therapeutics for Human Diseases, SciForum online, 2020.
  43. Eva María Domínguez-Martín; Epole Ntungwe; Catarina Teodosio; Vera M. S. Isca; Eleonora Colombo; Gabrielle Bangay; Tatiana Pinto; et al. "Synthesis of self-assembly nanoparticles of 7a-acetoxy-6ß -hydroxyroyleanone from Plectranthus hadiensis (Forssk.) Schweinf. ex Sprenger". Paper presented in IV Cbios Meeting, 2020.
  44. Epole Ntungwe; Máté Vágvölgyi; Jaime A. S. Coelho; Vera M. S. Isca; Lucilia Saraiva; Ana María Díaz-Lanza; Attila Hunyadi; et al. "Natural Cytotoxic Diterpenoids as a Potential Source of Drug Leads for cancer Therapy". Paper presented in IV Cbios Meeting, 2020.
  45. Vera M. S. Isca; Jaime A. S. Coelho; Carlos M. Monteiro; Epole Ntungwe N; Jelena Dinic; Diaz-Lanza Ana María; Candeias, Nuno R.; et al. "Novel class of P-glycoprotein inhibitors from Plectranthus spp.". Paper presented in WG3 meeting and International Online Symposium on “New Therapeutic Tools Against Preclinical Models of Multidrug Resistant Tumors”, 2020.
  46. Vera M. S. Isca; Jaime A. S. Coelho; Domínguez-Martín EM; Epole Ntungwe N; Carlos M. Monteiro; Dinic, Jelena; Diaz-Lanza Ana María; et al. "Royleanones from Plectranthus spp as P-glycoprotein inhibitors". Paper presented in Encontro Ciência 2020, 2020.
  47. Domínguez-Martín, Eva María; Ntungwe, Epole; Vera M. S. Isca; Colombo, Eleonora; Pinto, Tatiana; Pacheco, Catarina; Coelho, Jaime; et al. "Self-assembly nanoparticles of 7a-acetoxy-6ß-hydroxyroyleanone isolated from &lt;em&gt;Plectranthus hadiensis&lt;/em&gt;". Paper presented in 6th International Electronic Conference on Medicinal Chemistry, 2020.
    10.3390/ecmc2020-07286
  48. Domínguez-Martín EM; Epole Ntungwe N; Catarina Teodósio; Vera M. S. Isca; Pinto, Tatiana; Pacheco, Catarina; Diogo Dias; et al. "Estudio fitoquímico de las partes aéreas de Plectranthus hadiensis (Forssk.) Schweinf. ex Sprenger (Translation: “Phytochemical study of the aerial parts of Plectranthus hadiensis (Forssk.) Schweinf. ex Sprenger”)". Paper presented in XII Congreso de Fitoterapia Ciudad de Oviedo, 2020.
  49. Vera M. S. Isca; Epole Ntungwe N; Domínguez-Martín EM; Coimbra, Raquel; Tomasz Sliwinski; Sitarek, Przemyslaw; Ewa Skala; et al. "Abietane diterpenoids isolated from plectranthus spp. induce cancer cell death via apoptosis". Paper presented in in Virtual 7th EFMC Young Medicinal Chemists’ Symposium (EFMC-YMCS Virtual Event 2020), 2020.
  50. Vera M. S. Isca; Ricardo J. Ferreira; Catarina Garcia; Monteiro, Carlos M.; Dinic, Jelena; Suvi Holmstedt; Pesic, Milica; et al. "Molecular Docking Studies of Promising P-Glycoprotein Inhibitors obtained from Plectranthus spp.". Paper presented in Italian Young Medicinal Chemistry Virtual Meeting (I-YMC-VMEET), 2020.
  51. Epole Ntungwe; Vera M. S. Isca; Máté Vágvölgyi; Coimbra, Raquel; Domínguez-Martín EM; Attila Hunyadi; Duarte, Noélia; Diaz-Lanza Ana María; Rijo, Patrícia. "Natural Cytotoxic Diterpenoids, as Potential Drug Leads for cancer Therapy". Paper presented in Italian Young Medicinal Chemistry Virtual Meeting (I-YMC-VMEET), 2020.
  52. Vera M. S. Isca; Epole Ntungwe N; Domínguez-Martín EM; Tavares, Joana; Lucília Saraiva; Milica Pesic; Carlos A.M. Afonso; Rijo, Patrícia. "Diterpenoids from edible Plectranthus spp. as potential chemopreventive and therapeutic agents in cancer". Paper presented in III Lusófona’s Nutrition Meeting, 2020.
  53. Esra Nizam; Özlem Duymus; Vera M. S. Isca; Rijo, Patrícia; Nuray Erin. "Activation of protein kinase C epsilon (PKCe) and delta (PKCd) inhibits chemokine secretion enhancing antitumoral effects of CXCR2 antagonist". Paper presented in COST Action CA17104 STRATAGEM Annual Conference – 3rd MC meeting and 4th WGs meetings, 2020.
  54. Vera M. S. Isca; Ricardo J. Ferreira; Daniel J. V. A. Dos Santos; Lucília Saraiva; Carlos A.M. Afonso; Pesic, Milica; Rijo, Patrícia. "Cytotoxic royleanones from Plectranthus madagascariensis as agents to overcome multidrug resistant in cancer". Paper presented in COST Action CA17104 STRATAGEM Annual Conference – 3rd MC meeting and 4th WGs meetings, 2020.
  55. Dominguez-Martin, Eva; Bangay, Gabrielle; Antão, Ana; Ntungwe, Epole; Vera M. S. Isca; Diaz-Lanza, Ana; Rijo, Patrícia. "Updated review of the bioactive compounds isolated from &lt;em&gt;Plectranthus ecklonii &lt;/em&gt;Benth". 2020.
    10.3390/ecmc2020-07278
  56. Siopa, Filipa; Vera M.S. Isca; Rijo, Patrícia; Afonso, Carlos; Vera M. S. Isca; Epole Ntungwe N; Joana Tavares; et al. "Molecular docking as a tool to design novel PKC-d modulators for colon cancer therapy". Paper presented in 2019 Sino-Portugal Forum on Traditional Medicine, Nanchang Jiangxi, China, November, 2019, 2019.
  57. Rijo, Patrícia; Vera M. S. Isca; Epole Ntungwe N; Domínguez-Martín EM; Bessa, Cláudia; Lucília Saraiva; Carlos A.M. Afonso. "Abietane diterpenoids from Plectranthus spp. as a New Class of Protein Kinase C Modulators for Cancer Therapy". Paper presented in Physioma 2019, 2019.
  58. Joana Tavares; Epole Ntungwe; Vera M. S. Isca; Domínguez-Martín EM; Rijo, Patrícia. "Isolation study of a bioactive diterpene from Plectranthus ornatos Codd.". Paper presented in Bio.Natural, 2019.
  59. Epole Ntungwe N; Vera M. S. Isca; Máté Vágvölgyi; Joana Tavares; Domínguez-Martín EM; Diaz-Lanza Ana María; Spengler, Gabriella; Attila Hunyadi; Rijo, Patrícia. "Isolation of Two Bioactive Diterpenes from Plectranthus mutabilis codd.". Paper presented in Bio.Natural, 2019.
  60. Vera M. S. Isca; Epole Ntungwe N; Joana Tavares; Joana Almeida; Siopa, Filipa; Lucília Saraiva; Mattia Mori; et al. "Molecular docking as a tool to design royleanone derivatives from Plectranthus spp. as PKC-d modulators". Paper presented in 11th iMed.ULisboa Postgraduate Students Meeting & 4rd i3DU Meeting, 2019.
  61. Vera M. S. Isca; Epole Ntungwe N; Joana F. Almeida; Inês M. Ferreira; Pereira, Raquel; Jelena Dinic; Siopa, Filipa; et al. "Optimizing natural royleanones from Plectranthus spp. to overcome multidrug resistance in cancer". Paper presented in in 4rd scientific meeting of CQUL - Chemistry: Shaping the Future & 2019 Summer School (4ECQUL), 2019.
  62. João A. T. Caetano; Vera M. S. Isca; Bernardo J. R.; Oliveira, M. C. ; Fernandes, Ana Cristina. "Synthesis of value-added compounds from carbohydrates". Paper presented in XXVI Encontro Nacional da SPQ, 2019.
  63. Sitarek, Przemyslaw; Epole Ntungwe N; Vera M. S. Isca; Ewa Skala; Kowalczyk, Tomasz; Tomasz Sliwinski; Rijo, Patrícia. "Bioactivity of abietane diterpenoids from Plectranthus spp. against human cancer cells". Paper presented in Natural Products in Drug Discovery and Human Health (NatProdDDH), 2019.
  64. Vera M. S. Isca; Epole Ntungwe N; Siopa, Filipa; Lucília Saraiva; Mattia Mori; Maurizio Botta; Afonso, Carlos A. M.; Rijo, Patrícia. "Structure-based drug design of royleanone derivatives from Plectranthus spp. as PKC-d modulators". Paper presented in Natural Products in Drug Discovery and Human Health (NatProdDDH), 2019.
  65. Epole Ntungwe N; Vera M. S. Isca; Máté Vágvölgyi; Joana Tavares; Spengler, Gabriella; Attila Hunyadi; Rijo, Patrícia. "Bio-guided Isolation and Biological activity study of Coleon U from Plectranthus mutabilis Codd.". Paper presented in Ciência 2019, 2019.
  66. Epole Ntungwe N; Vera M. S. Isca; Máté Vágvölgyi; Spengler, Gabriella; Attila Hunyadi; Rijo, Patrícia. "Isolation and Biological activity study of coleon U from Plectranthus mutabilis Codd.". Paper presented in 4rd scientific meeting of CQUL - Chemistry: Shaping the Future & 2019 Summer School (4ECQUL), 2019.
  67. Epole Ntungwe N; Catarina Garcia; Vera M. S. Isca; Amílcar Roberto; Lucília Saraiva; Luis Monteiro Rodrigues; Rijo, Patrícia. "Plectranthus species: A source of Anticancer lead molecules". Paper presented in Fascination of Plants Day Event: “Plants promoting healthy diet”, 2019.
  68. Vera M. S. Isca; Epole Ntungwe N; Ricardo J. Ferreira; Tijana Stankovic; Amílcar Roberto; Pesic, Milica; Daniel J. V. A. Dos Santos; et al. "Royleanone Diterpenoids from Plectranthus spp. as P-glycoprotein inhibitors in multidrug resistant cells". Paper presented in XXVIème Congrès National de la SFBMEc, 2019.
  69. Vera M. S. Isca; Epole Ntungwe N; Joana F. Almeida; Inês M. Ferreira; Raquel Pereira; Jelena Dinic; Siopa, Filipa; et al. "Royleanone derivatives from Plectranthus spp. as new P-glycoprotein inhibitors". Paper presented in XXVI Encontro Nacional da SPQ, 2019.
  70. Epole Ntungwe N; Catarina Garcia; Vera M. S. Isca; Amílcar Roberto; Lucília Saraiva; Luis Monteiro Rodrigues; Rijo, Patrícia. "Anticancer lead molecules search from Plectranthus species". Paper presented in XXVIème Congrès National de la SFBMEc, 2019.
  71. Vera M. S. Isca; Catarina Garcia; Monteiro, Carlos M.; Ricardo J. Ferreira; Epole Ntungwe N; Tijana Stankovic; Joana M. Andrade; et al. "Cytotoxic derivatives of 6,7-dehydroroyleanone and 7a-acetoxy-6ß-hydroxyroyleanone". Paper presented in 3rd Training School “Computational modeling tools in drug discovery with natural products”, 2018.
  72. Epole Ntungwe; Vera M. S. Isca; Patrícia Rijo. "Bio-guided fractionation and isolation study of bioactive components from Plectranthus mutabilis Codd.". Paper presented in 1ª Conferência sobre Investigação em Produtos Naturais e Avícolas – Iniciativa conjunta CBIOS-CYTED, Lisbon, 2018.
  73. Vera M. S. Isca; Catarina Garcia; Carlos M. Monteiro; Duarte, Noélia; Carlos A.M. Afonso; Rijo, Patrícia. "Hemi-síntese de carbamatos a partir do diterpeno natural 6,7-dehidroxroyleanona". Paper presented in 1ª Conferência sobre Investigação em Produtos Naturais e Avícolas – Iniciativa conjunta CBIOS-CYTED, 2018.
  74. Vera M. S. Isca; Joana M. Andrade; Diogo Ladeiras; Ana S. Fernandes; Paulo Paixão; Clara Uriel; Ana M. Gomez; Noélia Duarte; Patrícia Rijo. "In vitro antimicrobial and cytotoxic activity of natural and hemi-synthetic isopimaranes". Paper presented in III CBIOS Seminar, Lisbon, 2018.
  75. Vera M. S. Isca; Joana M. Andrade; Diogo Ladeiras; Ana S. Fernandes; Paulo Paixão; Clara Uriel; Ana M. Gomez; Noélia Duarte; Patrícia Rijo. "Isopimarane-type diterpenoids - In vitro antimicrobial activity". Paper presented in 10th iMed.ULisboa Postgraduate Students Meeting & 3rd i3DU Meeting, Lisbon, 2018.
  76. Vera M. S. Isca; Joana M. Andrade; Diogo Ladeiras; Ana S. Fernandes; Paulo Paixão; Ana M. Gomez; Noélia Duarte; Patrícia Rijo. "In vitro antimicrobial activity of isopimarane-type diterpenoids". Paper presented in Chemistry at ULisboa & 2018 Summer School – 3rd Meeting of the College of Chemistry, Lisbon, 2018.
    10.3390/molecules25184250
  77. Vera M. S. Isca; Epole Ntungwe N; Joana Tavares; Pereira, Raquel; Siopa, Filipa; Carlos A.M. Afonso; Rijo, Patrícia. "Extraction and isolation of cytotoxic 7a-acetoxy-6ß-hydroxyroyleanone from P. grandidentatus and in silico prediction of new derivatives". Paper presented in Fascination of Plants Day Event: “Plants promoting healthy diet”, 2018.
  78. Isca, Vera M. S.; Seca, Ana M. L.; Pinto, Diana C. G. A.; Silva, Artur M. S.; Silva, Helena. "Some aromatic compounds from dichloromethane extract of Salicornia ramosissima". 2012.
Journal article
  1. Vera M. S. Isca; Bangay, Gabrielle; Salvatore Princiotto; Lucilia Saraiva; Daniel J. V. A. Dos Santos; Alfonso T. García-Sosa; Rijo, Patrícia. "Reactivity of 7a-acetoxy-6ß-hydroxyroyleanone and ability of its derivatives to modulate PKC isoform". Scientific Reports (2024):
    Under revision
  2. Patricia Rijo; Tamer M. M. Abuamara; Lashin Saad Ali Lashin; Sherif A. Kamar; Vera M. S. Isca; Tahseen S. Mohammed; Mohamed S. M. Abdrabo; et al. "Glycyrrhizic Acid Nanoparticles Subside the Activity of Methicillin-Resistant Staphylococcus aureus by Suppressing PBP2a". Pharmaceuticals (2024): https://doi.org/10.3390/ph17050589.
    10.3390/ph17050589
  3. Merecz-Sadowska, Anna; Vera M. S. Isca; Sitarek, Przemyslaw; Kowalczyk, Tomasz; Malecka, Magdalena; Zajdel, Karolina; Zielinska-Blizniewska, Hanna; et al. "Exploring the Anticancer Potential of Semisynthetic Derivatives of 7a-Acetoxy-6ß-hydroxyroyleanone from Plectranthus sp.: An In Silico Approach". International Journal of Molecular Sciences 25 8 (2024): 4529. http://dx.doi.org/10.3390/ijms25084529.
    10.3390/ijms25084529
  4. Vera M. S. Isca; Przemyslaw Sitarek; Anna Merecz-Sadowska; Magdalena Malecka; Monika Owczarek; Joanna Wieczfinska; Radoslaw Zajdel; et al. "Anticancer Effects of Abietane Diterpene 7a-Acetoxy-6ß-hydroxyroyleanone from Plectranthus grandidentatus and Its Semi-Synthetic Analogs: An In Silico Computational Approach". Molecules (2024): https://doi.org/10.3390/molecules29081807.
    10.3390/molecules29081807
  5. Filipe, Márcia S.; Domínguez-Martín, Eva M.; Pires, Tânia C. S. P.; Finimundy, Tiane C.; Melgar, Bruno; Mandim, Filipa; Vera M. S. Isca; et al. "Biological Activity of 6,7-Dehydroxyroyleanone and Derivatives Obtained from Plectranthus aliciae (Codd) A.J.Paton". ACS Omega 9 16 (2024): 18113-18118. http://dx.doi.org/10.1021/acsomega.3c10071.
    Published • 10.1021/acsomega.3c10071
  6. Domínguez-Martín EM; Epole Ntungwe N; Vera M. S. Isca; Salvatore Princiotto; Diaz-Lanza Ana María; André, Vânia; Rijo, Patrícia. "Antibiotic coordination frameworks (ACFs) against antibiotic resistance - How to involve students through experimental practices in the search for solutions to public health problems". Journal of Chemical Education (2024): http://dx.doi.org/10.1021/acs.jchemed.3c01125.
    Published • 10.1021/acs.jchemed.3c01125
  7. Rodrigues, Luis Monteiro; Guerreiro, Iris; Vera M. S. Isca; Gregório, João. "Charting the course of Physiology within the post-Bologna European higher education area: Insights from Portugal". Physiological Reports 12 5 (2024): http://dx.doi.org/10.14814/phy2.15959.
    10.14814/phy2.15959
  8. Luis Monteiro Rodrigues; Guerreiro, Íris; Vera M. S. Isca; Gregório, João. "Characterization of Physiology teaching in the European Higher Education Area - a Case Study from Portugal in the Post-Bologna Process". Physiological Reports (2024):
    Under revision
  9. Catarina Rosado; Luís Monteiro Rodrigues; Bernardo Palma; Miguel Remondes; Marina Badenes; Ângela Afonso; Constantinos Athanassopoulos; et al. "2023 CBIOS Scientific Seminars - Book of Abstracts". Biomedical and Biopharmaceutical Research (2024): https://doi.org/10.19277/bbr.20.2.330.
    10.19277/bbr.20.2.330
  10. Luís M. T. Frija; Bruno E. C. Guerreiro ; Inês C. C. Costa ; Vera M. S. Isca; Lucília Saraiva; Neves, Beatriz G.; Mariana Magalhães; et al. "Distinctive Azole-based Conjugates as Potential Anticancer and Antimicrobial Agents: A Preliminary Biological Survey". Journal of Heterocyclic Chemistry (2023):
    Under revision
  11. Cláudia Bessa; Joana B. Loureiro; Matilde Barros; Vera M. S. Isca; Vilma A. Sardão; Paulo J. Oliveira; Raquel L. Bernardino; et al. "Counteracting Colon Cancer by Inhibiting Mitochondrial Respiration and Glycolysis with a Selective PKCd Activator". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24065710.
    10.3390/ijms24065710
  12. Luis Monteiro Rodrigues; Carmen Brás da Silva; Telmo Pereira; Íris Guerreiro; Vera Isca; João Gregório; Diogo Santos-Ferreira; et al. "Aprender e Ensinar em Fisiologia". Biomedical and Biopharmaceutical Research (2023): https://doi.org/10.19277/bbr.20.2.323.
    10.19277/bbr.20.2.323
  13. Márcia Santos Filipe; Vera M. S. Isca; Epole Ntungwe; Salvatore Princiotto; Diaz-Lanza Ana María; Rijo, Patrícia. "Lethality Bioassay using Artemia salina L.". Journal of Visualized Experiments (2022): https://review.jove.com/t/64472/lethality-bioassay-using-artemia-salina-l.
    10.3791/64472
  14. Gomes, Rafael F. A.; Isca, Vera M. S.; Andrade, Késsia; Rijo, Patrícia; Afonso, Carlos A. M.. "Functionalized Cyclopentenones and an Oxime Ether as Antimicrobial Agents". ChemMedChem 16 18 (2021): 2781-2785. http://dx.doi.org/10.1002/cmdc.202100369.
    10.1002/cmdc.202100369
  15. Nuray Erin; Esra Tavsan; Özlem Akdeniz; Vera M.S. Isca; Patricia Rijo. "Rebound increases in chemokines by CXCR2 antagonist in breast cancer can be prevented by PKCd and PKCe activators". Cytokine (2021): 155498-155498. https://doi.org/10.1016/j.cyto.2021.155498.
    10.1016/j.cyto.2021.155498
  16. Epole Ntungwe; Vera M. S. Isca; Ana María Díaz-Lanza; Carlos A. M. Afonso; Patrícia Rijo. "General Toxicity screening of Royleanone derivatives using an Artemia salina model". Journal Biomedical and Biopharmaceutical Research (2021): https://doi.org/10.19277/bbr.18.1.254.
    10.19277/bbr.18.1.254
  17. Tomasz Kowalczyk; Anna Merecz-Sadowska; Patricia Rijo; Vera M. S. Isca; Laurent Picot; Marzena Wielanek; Tomasz Sliwinski; Przemyslaw Sitarek. "Preliminary Phytochemical Analysis and Evaluation of the Biological Activity of Leonotis nepetifolia (L.) R. Br Transformed Roots Extracts Obtained through Rhizobium rhizogenes-Mediated Transformation". Cells 10 5 (2021): 1242-1242. https://doi.org/10.3390/cells10051242.
    10.3390/cells10051242
  18. Ntungwe, Epole; Isca, Vera M. S.; Díaz Lanza, Ana María; Afonso, Carlos A. M.; Rijo, Patrícia. "Avaliação da toxicidade geral de derivados de Roileanonas pelo ensaio de letalidade de Artemia salina". (2021): http://hdl.handle.net/10437/12810.
  19. Eva María Domínguez-Martín; Ana Margarida Antão; Epole Ntungwe; Vera Isca; Ana María Díaz-Lanza; Patrícia Rijo. "Phytochemical and Pharmacological Study of Plectranthus ecklonii Benth". Proceedings 83 1 (2020): 8-8. https://doi.org/10.3390/IECBM2020-08567.
    10.3390/IECBM2020-08567
  20. Garcia, Catarina; Isca, Vera M. S.; Filipe Preira; Monteiro, Carlos M.; Ntungwe, Epole; Sousa, Francisco; Dinic, Jelena; et al. "Royleanone Derivatives From Plectranthus spp. as a Novel Class of P-Glycoprotein Inhibitors". Frontiers in Pharmacology 11 (2020): http://dx.doi.org/10.3389/fphar.2020.557789.
    10.3389/fphar.2020.557789
  21. Tomasz Sliwinski; Przemyslaw Sitarek; Ewa Skala; Vera M. S. Isca; Ewelina Synowiec; Tomasz Kowalczyk; Michal Bijak; Patrícia Rijo. "Diterpenoids from Plectranthus spp. as Potential Chemotherapeutic Agents via Apoptosis". Pharmaceuticals 13 6 (2020): 123-123. https://doi.org/10.3390/ph13060123.
    10.3390/ph13060123
  22. Vera M. S. Isca; Milan Sencanski; Nenad Filipovic; Daniel J. V. A. Dos Santos; Ana Cipak Gašparovic; Lucília Saraíva; Carlos A. M. Afonso; Patrícia Rijo; Alfonso T. García-Sosa. "Activity to Breast Cancer Cell Lines of Different Malignancy and Predicted Interaction with Protein Kinase C Isoforms of Royleanones". International Journal of Molecular Sciences (2020): https://doi.org/10.3390/ijms21103671.
    10.3390/ijms21103671
  23. Epole Ntungwe N; Eva M. Domínguez-Martín; Amilcar Roberto; Joana Tavares; Vera Isca; Paula Pereira; Maria-João Cebola; Patrícia Rijo. "Artemia species: An important tool to screen general toxicity samples". Current Pharmaceutical Design (2020): https://doi.org/10.2174/1381612826666200406083035.
    10.2174/1381612826666200406083035
  24. Vera M. S. Isca; Epole Ntungwe; Eva Maria Dominguez-Martin; Joana Tavares; Lucília Saraiva; Milica Pesic; Carlos A.M. Afonso; Rijo, Patrícia. "III Lusófona’s Nutrition Meeting". Biomedical and Biopharmaceutical Research Journal 17 1 (2020): 1-15. http://dx.doi.org/10.19277/bbr.17.1.229.
    10.19277/bbr.17.1.229
  25. Vera M. S. Isca; Ricardo J. Ferreira; Catarina Garcia; Carlos M. Monteiro; Jelena Dinic; Suvi Holmstedt; Vânia André; et al. "Molecular Docking Studies of Royleanone Diterpenoids from Plectranthus spp. as P-Glycoprotein Inhibitors". ACS Medicinal Chemistry Letters (2020): https://doi.org/10.1021/acsmedchemlett.9b00642.
    10.1021/acsmedchemlett.9b00642
  26. Faustino, Célia; Francisco, Ana P.; Isca, Vera M. S.; Duarte, Noélia. "Cytotoxic Stilbenes and Derivatives as Promising Antimitotic Leads for Cancer Therapy". Current Pharmaceutical Design 24 36 (2019): 4270-4311. http://dx.doi.org/10.2174/1381612825666190111123959.
    10.2174/1381612825666190111123959
  27. Ribeiro, Nadia; Galvao, Adelino M.; Gomes, Clara S. B.; Ramos, Helena; Pinheiro, Rute; Saraiva, Lucilia; Ntungwe, Epole; et al. "Naphthoylhydrazones: coordination to metal ions and biological screening". New Journal of Chemistry (2019): http://hdl.handle.net/10400.1/14147.
    10.1039/c9nj01816f
  28. Isca, Vera. "Direct synthesis of a-aminophosphonates from biomass resources catalyzed by HReO4". Green Chemistry (2018):
    10.1039/C8GC01343H
  29. Ferreira, D.; Isca, V.M.S.; Leal, P.; Seca, A.M.L.; Silva, H.; de Lourdes Pereira, M.; Silva, A.M.S.; Pinto, D.C.G.A.; Vera M. S. Isca. "Salicornia ramosissima: Secondary metabolites and protective effect against acute testicular toxicity". Arabian Journal of Chemistry 11 1 (2018): 70-80. http://www.scopus.com/inward/record.url?eid=2-s2.0-84975709066&partnerID=MN8TOARS.
    10.1016/j.arabjc.2016.04.012
  30. Isca, V.M.S.; Seca, A.M.L.; Pinto, D.C.G.A.; Silva, H.; Silva, A.M.S.; Isca, Vera. "Saliramophenol, an unprecedented natural t-butylphenol derivative from Salicornia ramosissima J. Woods". RSC Advances 5 75 (2015): 61380-61382. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937468528&partnerID=MN8TOARS.
    10.1039/c5ra10893d
  31. Isca, V.M.S.; Seca, A.M.L.; Pinto, D.C.G.A.; Silva, H.; Silva, A.M.S.; Isca, Vera. "Lipophilic profile of the edible halophyte Salicornia ramosissima". Food Chemistry 165 (2014): 330-336. http://www.scopus.com/inward/record.url?eid=2-s2.0-84902655506&partnerID=MN8TOARS.
    10.1016/j.foodchem.2014.05.117
Newsletter article
  1. Vera M. S. Isca. "New Class of Protein Kinase C Modulators: from Ethnopharmacological to Nanoparticles", Boletim da Sociedade Portuguesa de Química, 2024, DOI: 10.52590/M3.P709.A30002767.
Online resource
  1. Vera M. S. Isca; Epole Ntungwe N; Raquel Pereira; Domínguez-Martín EM; Siopa, Filipa; Carlos A.M. Afonso; Rijo, Patrícia. Animated Poster in Annual CQE Meeting: Phytochemical study and derivatization of a cytotoxic royleanone from P. grandidentatus. 2020. https://twitter.com/Vera89733278/status/1265038955227086848.
  2. Eva Maria Dominguez-Martin; Epole Ntungwe N; Vera M. S. Isca; Eleonora Colombo; Daniel Passarela; Rijo, Patrícia. Animated Poster in Annual CQE Meeting: Self-assembly nanoparticles of Plectranthus hadiensis diterpenoids. 2020. https://twitter.com/Eva_M_DM/status/1265024572631527425.
  3. Epole Ntungwe N; Vera M. S. Isca; Máté Vágvölgyi; Joana Tavares; Gabriela Spengler; Milica Pesic; Attila Hunyadi; et al. Animated Poster in Annual CQE Meeting: Abietane Diterpenoids from Plectranthus mutabilis Codd.. 2020. https://twitter.com/Gently2016/status/1264886258804887552.
Thesis / Dissertation
  1. "New class of protein kinase C modulators: from ethnopharmacological to nanoparticles". PhD, Universidade de Lisboa Faculdade de Farmácia, 2023.
  2. Isca, Vera Mónica Sousa. "Salicornia ramosissima J. Woods: estudo fitoquímico das partes aéreas". Master, 2013. http://hdl.handle.net/10773/11818.

Other

Other output
  1. Valuable compounds on conifers, macroalgae and halophyte species. As part of our on-going investigation on bioactive secondary metabolites, we carried out the phytochemical study of the endemic conifer Juniperus brevifolia and the macroalga Cystoseira abies-marine from Azores Islands, and also of the halophyte Salicornia ramosissima from Aveiro lagoon. This communication gives an overview on the isolation, structural characterization and bioactivity of the most. 2013. Isca, Vera M. S.; Gouveia, Vera F.; Seca, Ana M. L.; Barreto, Maria do Carmo; Pinto, Diana C. G. A.; Silva, Artur M. S.; Kijjoa, Anake. http://hdl.handle.net/10400.3/2350.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/07/13 PKC-a activation with new semi-synthetic 7a-acetoxy-6ß-hydroxyroyleanone derivatives for breast cancer therapeutics International Congress on Natural Products Research
(Kraków, Poland)
2024/05/28 Targeting breast cancer trough PKC-a activation with new 7a-acetoxy-6ß-hydroxyroyleanone derivatives 8th Cancer World Congress
(Dubrovnik, Croatia)
2024/05/07 Breast Cancer Therapeutics through PKC-a activation: Novel 7a-acetoxy-6ß-hydroxyroyleanone Semi-synthetic Derivatives 3rd International Conference on Cancer Science and Theraphy
(Bangkok)
2024/01 Exploring the cytotoxic diterpenoid 7a-acetoxy-6ß-hydroxyroyleanone from Plectranthus spp. as a PKC-a activator for breast cancer therapy 15th National Organic Chemistry Meeting & 8th National Medicinal Chemistry Meeting
(Faro, Portugal)
2023/11/10 7a-acetoxy-6ß-hydroxyroyleanone from Plectranthus spp. as a lead compound for breast cancer therapy V Jornadas CBIOS
(Lisbon, Portugal)
2023/11 7a-acetoxy-6ß-hydroxyroyleanone as lead compound: from extraction optimization to hybrid nanoparticles for breast cancer therapy 9th International Electronic Conference on Medicinal Chemistry
2023/07/13 Enhancing Breast Cancer Therapy via Protein Kinase a Activation: Derivatization of Natural Cytotoxic Diterpenoid III Bio.Natural- Bioactive Natural Products Research Conference
(Lisbon, Portugal)
2023/07 Molecular docking studies and in vitro analysis of P-gp inhibitors from Plectranthus diterpenoids III Bio.Natural- Bioactive Natural Products Research Conference
(Lisbon, Portugal)
2023/03/18 Potential new formulations with royleanone derivatives to modulate PKC activity International symposium on medicinal and aromatic plants- SIPAM-6
(Djerba, Tunisia)
2023/01/26 Antimicrobial screening of Plectranthus extracts for applications against antibiotic resistant bacterial infections 1st Meeting of COST Action ACTION CA21145 – European Network for diagnosis and treatment of antibiotic-resistant bacterial infections (EURESTOP)
(Lisbon, Portugal)
2022/08/17 Diterpenoids from edible Plectranthus spp. as potential therapeutic agents in cancer 32nd International Conference on Nutraceuticals and Natural Medicine
(Scotland, United Kingdom)
2022/06/30 Nanosystem of royleanone diterpenoids from Plectranthus spp to improve targeted delivery into cancer cells InnovDelivery 2022
(Lisbon, Portugal)
2022/05/24 PKC modulation with royleanone derivatives to target breast cancer 1st African Conference on Natural Products & Related Fields
2022/05 Royleanone diterpenoids from Plectranthus spp. demonstrate P-glycoprotein inhibition PSE Trends in Natural Products Research: A PSE Young Scientists’ Meeting
(Crete, Greece)
2022/04/20 Targeting breast cancer through PKC modulation with abietane royleanone derivatives 14th Nacional Organic Chemistry Meeting and 7th Nacional Therapeutic Chemistry Meeting
(Caparica, Portugal)
2021/01/27 Overcame MDR with New Cytotoxic Royleanones from Plectranthus spp. Natural Products in Cancer Research Virtual Meeting
United Scientific Group
2021/01/27 Potential Anti-cancer Diterpenoids from Plectranthus mutabilis Codd. Natural Products in Cancer Research Virtual Meeting
2020/12/15 Innovative nanosystems with natural cytotoxic royleanone diterpenes from Plectranthus spp. COST Action 17104 (STRATAGEM) WG2 Meeting and International Online Symposium on “Synthesis and nanodelivery strategies for new therapeutic tools against Multidrug Resistant Tumours”
2020/11/23 Insight into P-glycoprotein inhibition of new diterpene royleanones from Plectranthus spp. IV CBIOS Seminar
(Lisbon, Portugal)
2020/11/04 Novel class of P-glycoprotein inhibitors from Plectranthus spp. WG3 meeting and International Online Symposium on “New Therapeutic Tools Against Preclinical Models of Multidrug Resistant Tumors
2020/10 Using natural cytotoxic diterpenoids for innovative nanosystems Cancer Research & Drug Development (Cancer R&D) 2020 Virtual
2020/02 Plectranthus mutabilis Codd as a source of Anti-MDR Diterpenoids COST Action CA17104 STRATAGEM Annual Conference – 3rd MC meeting and 4th WGs meeting
(Belgrade, Serbia)
2019/10 Phytochemical study and derivatization of a cytotoxic royleanone from P. grandidentatus Modern Methods of Structure Elucidation (MMSE) – 2019
(Lisbon, Portugal)
2019/10 Self-assembly nanoparticles of Plectranthus hadiensis diterpenoids Modern Methods of Structure Elucidation (MMSE) – 2019
(Lisbon, Portugal)
2019/10 Bioguided isolation and biological activity of Diterpenes from Plectranthus mutabilis Codd. Modern Methods of Structure in Modern Methods of Structure Elucidation (MMSE) – 2019
(Lisbon, Portugal)
2019/09/20 Plectranthus species: as a source of anti-MDR diterpenoids Working Group, WG1 meeting, COST Action: CA17104
(Viena, Austria)
2019/09 In silico approach for design of new derivatives of 7a-acetoxy-6ß-hydroxyroyleanone from Plectranthus spp. based on PKC-d activation Bio.Natural
(Lisbon, Portugal)
2019/06/26 Plectranthus mutabilis: Phytochemistry and Biological activity study CBIOS Science session
(Lisbon, Portugal)
2019/06/05 Lead Cytotoxic Royleanones and derivatives from Plectranthus spp. CBIOS Science session
(Lisbon, Portugal)
2019/02 Royleanones from Plectranthus spp. as P-glycoprotein inhibitors in multidrug resistant cells Meeting dedicated to Early Career Investigators (ECIs), COST Association
(Bruxelas, Belgium)
2019/02 Plectranthus species: anticancer lead molecules search Meeting dedicated to Early Career Investigators (ECIs), COST Association
(Bruxelas, Belgium)
2018/06 One-pot synthesis of nitrogen compounds from biomass resource 29th International Carbohydrate Symposium
(Lisbon, Portugal)
2018/06 One-pot synthesis of nitrogen and phosphorus compounds from biomass resources Chemistry at ULisboa & 2018 Summer School – 3rd Meeting of the College of Chemistry
(Lisbon, Portugal)
2015/10 Salicornia ramosissima an edible halophyte with nutritional value and a source of a unique natural compound in 2nd International Symposium on Profiling (ISPROF)
(Caparica, Portugal)
2013/06 Valuable compounds on conifers, macroalgae and halophyte species XXIII Encontro Nacional da SPQ
(Aveiro, Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2024/11/04 - Current Workshop: "The chemistry of Scents essential oils: from molecular models to virtual reality" in the pharmaceutical science week. (2024/11/04)
Workshop (Co-organisor)
 Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal
2023/07 - 2023/07 III Bio.Natural- Bioactive Natural Products Research Conference (2023/07/13)
Conference (Member of the Organising Committee)
 Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal
2023/01/26 - 2023/01/27 1st Meeting of COST Action ACTION CA21145 – European Network for diagnosis and treatment of antibiotic-resistant bacterial infections (EURESTOP) (2023/01/26)
Conference (Member of the Organising Committee)
 Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal
2023/01/23 - 2023/01/25 Training school "Bioinformatics and Computational tools in antibacterial research" of the COST Action ACTION CA21145 - European Network for diagnosis and treatment of antibiotic-resistant bacterial infections (EURESTOP) (2023/01/23)
Workshop (Member of the Organising Committee)
 Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal
2019/10 - 2019/10 Physioma 2019 - 1º Encontro Internacional da Sociedade Portuguesa de Fisiologia (2019/10/10)
Conference (Member of the Organising Committee)
 Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal
2019/09 - 2019/09 Bio.Natural - Bioactive Natural Products Research Conference (2019/09/26)
Conference (Member of the Organising Committee)
2019/05 - 2019/05 Fascination of Plants Day Event: Plants promoting healthy diet (2019/05/18)
Conference (Member of the Organising Committee)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2024/09/27 - 2024/09/27 Noite Europeia dos Investigadores 2024 (European Rersearchers’ Night) – Stand de demonstração CBIOS
Workshop
 Noite Europeia dos Investigadores 2024
Pavilhão do Conhecimento-Centro Ciência Viva, Portugal
2024/02/19 - 2024/02/20 Open Day of Universidade Lusófona - Centro Universitário Lisboa
Other
Universidade Lusófona de Humanidades e Tecnologias Escola de Ciências e Tecnologias da Saúde, Portugal
2023/02/13 - 2023/02/13 Open Day of Universidade Lusófona - Centro Universitário Lisboa
Other
Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal
2022/10 - 2022/10 Noite Europeia dos Investigadores 2022 (European Rersearchers’ Night SciCli) – Stand de demonstração CBIOS
Exhibition
2022/09/30 - 2022/09/30 FIC.A - Festival Internacional de Ciência - Stand de demonstração CBIOS
Exhibition
2022/05/17 - 2022/05/17 Meeting Ciência 2022 - Stand "ESTRATÉGIAS DE SAÚDE SUSTENTÁVEIS@CBIOS"
Exhibition
2021/10/30 - 2021/10/30 Noite Europeia dos Investigadores 2021 (European Rersearchers' Night SciCli), CBIOS demo Stand
Exhibition
2021/10 - 2021/10 FIC.A - Festival Internacional de Ciência, Lisbon, CBIOS demo Stand
Exhibition

Association member

Society Organization name Role
2023 - Current Phytochemical Society of Europe (PSE)
2020 - Current European Society of Clinical Investigation (ESCI)
2019 - Current Sociedade Portuguesa de Química (SPQ)
2019 - Current Society for Medicinal Plant and Natural Product Research (GA)
2019 - Current Sociedade Portuguesa de Fisiologia (SPFis)

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2024/10 - Current Coordenação da disciplina de Análise Estrutural Mestrado em Química de Bioativos Naturais (Mestrado) Universidade Lusófona de Humanidades e Tecnologias Escola de Ciências e Tecnologias da Saúde, Portugal
2024/10 - Current Quimíca dos Bioativos Naturais Mestrado em Química de Bioativos Naturais (Mestrado) Universidade Lusófona de Humanidades e Tecnologias Escola de Ciências e Tecnologias da Saúde, Portugal
2024/02 - Current Química Medicinal Orgânica Mestrado Integrado em Ciências Farmacêuticas (Mestrado integrado) Universidade Lusófona de Humanidades e Tecnologias Escola de Ciências e Tecnologias da Saúde, Portugal
2022 - Current Farmacognosia e Fitoterapia II Ciências Farmacêuticas (Mestrado integrado) Universidade Lusófona de Humanidades e Tecnologias Escola de Ciências e Tecnologias da Saúde, Portugal
2020 - Current Farmacognosia e Fitoterapia I Ciências Farmacêuticas (Mestrado integrado) Universidade Lusófona de Humanidades e Tecnologias Escola de Ciências e Tecnologias da Saúde, Portugal
2020 - Current Química Medicinal Inorgânica Ciências Farmacêuticas (Mestrado integrado) Universidade Lusófona de Humanidades e Tecnologias Escola de Ciências e Tecnologias da Saúde, Portugal
2019 - 2024 Produtos de Origen Natural Produtos de Saúde e Suplementos Alimentares (Mestrado) Universidade Lusófona de Humanidades e Tecnologias Escola de Ciências e Tecnologias da Saúde, Portugal
2019 - 2020 Parasitologia Ciências Farmacêuticas (Mestrado integrado) Universidade Lusófona de Humanidades e Tecnologias Escola de Ciências e Tecnologias da Saúde, Portugal
2017/09 - 2018/07 Assistente estagiário na disciplina de Farmacognosia e Fitoterapia I e II Mestrado Integrado em Ciências Farmacêuticas (Mestrado integrado) Universidade Lusófona de Humanidades e Tecnologias Escola de Ciências e Tecnologias da Saúde, Portugal

Mentoring / Tutoring

Topic Student name
2024/02 - 2024/06 Projecto de Licenciatura Bioquímica Ana Sofia Amaral
2023/02 - 2023/07 Erasmus Master Dissertation Laura Malvestuto
2023/02 - 2023/06 Projecto de Licenciatura Bioquímica Tirsa Pinheiro
2022/09/19 - 2022/09/23 SEP intership at CBIOS, Universidade Lusófona Lyna Taouchichet
2022/02/07 - 2022/06/15 SEP intership at CBIOS, Universidade Lusófona Joy Rijstenbil
2022/03 - 2022/06 Projecto de Licenciatura Bioquímica Ana Francisca Carvalho de Menezes Duro
2022/02/14 - 2022/03/11 SEP intership at CBIOS, Universidade Lusófona Joy Rijstenbil
2022/01/31 - 2022/02/15 SEP intership at CBIOS, Universidade Lusófona SAFIYE NUR YAMAN
2020/04 - 2020/06 Projecto de Licenciatura em Ciências da Nutrição Diogo Dias
2020/03 - 2020/06 Dissertação de Mestrado Integrado em Ciências Farmacêuticas Ana Raquel Pereira
2019/10 - 2019/11 Partnership program “Advanced training program in Health Sciences and Technologies”; ULHT/AKIES-Jiangxi University of Traditional Chinese Medicine, China Chen Kang
2019/10 - 2019/11 Partnership program “Advanced training program in Health Sciences and Technologies”; ULHT/AKIES-Jiangxi University of Traditional Chinese Medicine, China Zhu Lin
2019/10 - 2019/11 Partnership program “Advanced training program in Health Sciences and Technologies”; ULHT/AKIES-Jiangxi University of Traditional Chinese Medicine, China Xiao Falin
2019/10 - 2019/11 Partnership program “Advanced training program in Health Sciences and Technologies”; ULHT/AKIES-Jiangxi University of Traditional Chinese Medicine, China Cheng Yuyao
2019/10 - 2019/11 Partnership program “Advanced training program in Health Sciences and Technologies”; ULHT/AKIES-Jiangxi University of Traditional Chinese Medicine, China Ye Xian-wen
2019/03 - 2019/10 Dissertação de Mestrado Integrado em Ciências Farmacêuticas Joana Tavares
2019/03 - 2019/05 Projecto de Mestrado Integrado em Ciências Farmacêuticas Ana Raquel Pereira
2018/02 - 2018/06 Projecto de Mestrado Integrado em Ciências Farmacêuticas Inês M. Ferreira
2018/02 - 2018/02 Projecto de Mestrado Integrado em Ciências Farmacêuticas Joana F. Almeida
Distinctions

Award

2024 Pharmaceuticals “2024 Best PhD Thesis Award”
MDPI AG, Switzerland
2024 Best Poster Award: "In silico evaluation of semi-synthetic derivatives of 7a-acetoxy-6ß-hydroxyroyleanone for anticancer potential"
Conference on Medicinal and Aromatic Plants of Southeast European Countries , Turkey
2023 First winner of the poster contest: Natural cytotoxic royleanones and Hermetia illucens as promising nano-assemblies conjugconjugated, in International symposium on medicinal and aromatic plants- SIPAM-6, Djerba, Tunisia on 18-21, March 2023.
2021 Best flash communication: Inhibition of P-glycoprotein activity to overcome multidrug resistance in cancer with new diterpene royleanones from Plectranthus spp., in 7th International Electronic Conference on Medicinal Chemistry
MDPI AG, Switzerland
2020 Biomolecules 2020 Travel Award
MDPI AG, Switzerland
2019 Honorable mention for the flash communication: In silico approach for design of new derivatives of 7a-acetoxy-6ß-hydroxyroyleanone from Plectranthus spp. based on PKC-d activation, in Bio.Natural Meeting
Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal
2018 Honorable mention for the poster: In vitro antimicrobial and cytotoxic activity of natural and hemi-synthetic isopimaranes, in III CBIOS Seminar
Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal

Other distinction

2024 Selected for an ITC grant
COST Action CA21145 EURESTOP, Belgium
2019 Selected flash communication: In silico approach for design of new derivatives of 7a-acetoxy-6ß-hydroxyroyleanone from Plectranthus spp. based on PKC-d activation, in Bio.Natural Meeting
Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal
2019 Selected for an International SHORT-TERM SCIENTIFIC MISSION (STSM)
ECOST-STSM-CM1407-42884, Belgium
2018 PhD grant SFRH/BD/137671/2018
Fundação para a Ciência e a Tecnologia, Portugal