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Pedro Lourenço completed his Bachelor's degree in Biochemistry at the University of Beira Interior (UBI) in 2021 and obtained his Master’s degree in 2023, graduating with a final grade of 17/20. His dissertation, “Selective targeting of B-MYB G-quadruplex using fluorescent probes,” supervised by Dr. Carla Cruz, was graded 19/20 and focused on G-quadruplex (G4) structure characterization and ligand interaction using NMR, circular dichroism, FRET-melting, UV, and fluorescence spectroscopy. He also gained skills in chemical synthesis, bioimaging, and cellular assays, establishing a multidisciplinary research profile that combines chemistry, biophysics, and biology. Currently, he holds a research fellowship (ref. CICS-UBI_BI_LABORATÓRIOS DE INVESTIGAÇÃO_2025) at CICS-UBI, and from 2023 to 2024, he was awarded a fellowship (ref. UIDP/00709/2020) within the NMR infrastructure at CICS-UBI, ranking first. His work involves nucleic acid structural studies by NMR and other spectroscopic techniques, cellular evaluation, assistance to other researchers in NMR acquisition and data processing, and maintenance of 400 MHz and 600 MHz cryoprobe NMR spectrometers, integrated in the PTNMR national infrastructure, which he is also a part of. He also provides NMR services to the international company WUD. He is the author of seven peer-reviewed scientific publications, being first author in four of them, published in leading journals such as the International Journal of Biological Macromolecules (doi: 10.1016/j.ijbiomac.2024.131055;IF=7.7;Q1), Pharmaceutics (doi: 10.3390/pharmaceutics16040541;IF=4.9;Q1), Biomolecules (doi: 10.3390/biom15030410;IF=4.8;Q1), and Molecules (doi: 10.3390/molecules30081673;IF=4.2;Q2). He also co-authored three additional articles in Chemistry - A European Journal (10.1002/chem.202400285;IF=4.3;Q2), ChemMedChem (10.1002/cmdc.202400591;IF=3.6;Q2), and Molecules (10.3390/molecules29133182;IF=4.2;Q2). Moreover, he is the first author of a book chapter entitled “Therapeutic applications of nucleic acid aptamers”, accepted for publication in the Springer Handbook of Medical Biotechnology. He has presented his research in six oral and seven poster communications at national and international conferences. He is involved in four funded research projects: “Structural and cellular evaluation of G-quadruplex on B-MYB oncogene” (ref. 2024.07170, FCT), “AquaClean – Monitorização e remoção de disruptores endócrinos em águas superficiais” (ref. PL24-00059, FCT, Fundação La Caixa), and two concluded ones: “PAPILOMA – Preclinical validation of a new gel vaginal prototype” (ref. UIDP/00709/2020, FCT), and a structural study on let-7e precursor miRNA/nucleolin complex (ref. APPID: 2473, Instruct-ERIC). He is also part of the UBI-CGD Innovation Award 2024 OralCare project and was awarded a G4thering 2025 Student Travel Grant funded by the G4thering Conference Organizing Committee (USA). His international experience includes an internship at ICMUB, Dijon (Feb–Mar 2025), and participation in workshops at the University of Waterloo, Canada (06/2024), and IECB Bordeaux (10/2024). In parallel with research, Pedro Lourenço has contributed to academic teaching as a tutor in the Biochemistry I and Spectroscopic Methods practical classes (30 h) and has supervised two BSc students in their final projects (Josué Neves and Diogo Dias). He is also an active member of organizing committees of multiple scientific events, including the “XIX Annual CICS-UBI Symposium,” the international “4th Biophysics Festival 2024” and “5th Biophysics Festival 2025,” the international “Theoretical Course: NMR for Metabolic Profiling” (June 2024), and the “3rd Edition Hands-on Course NMR: from theory to practice” (Dec 2023).
Identification

Personal identification

Full name
Pedro Afonso Amaro Lourenço

Citation names

  • Lourenço, Pedro

Author identifiers

Ciência ID
071C-E24D-2A32
ORCID iD
0000-0002-1919-9553
Scopus Author Id
58923692300

Email addresses

  • pedro.afonso.amaro.lourenco@ubi.pt (Professional)

Telephones

Mobile phone
  • 965014322 (Personal)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Biophysics
  • Natural sciences - Biological Sciences - Biochemical Research Methods
  • Natural sciences - Biological Sciences - Biochemistry
  • Exact Sciences - Chemical Sciences - Organic Chemistry
  • Natural sciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2021/09/21 - 2023/12/13
Concluded
Bioquímica (Mestrado)
Universidade da Beira Interior, Portugal
"Selective Targeting of B-MYB G-quadruplex using fluorescent probes" (THESIS/DISSERTATION)
17
2022/07/11 - 2022/07/14
Concluded
Formação de Jovens Investigadores CICS-UBI (Outros)
Universidade da Beira Interior, Portugal
2018/09/21 - 2021/07/10
Concluded
Bioquímica (Licenciatura)
Universidade da Beira Interior, Portugal
13
Affiliation

Science

Category
Host institution
Employer
2025/01 - Current Researcher (Research) RISE-Health, Universidade da Beira Interior, Portugal, Portugal
RISE-Health, Universidade da Beira Interior, Portugal, Portugal
2025/02/02 - 2025/03/02 Visiting Researcher (Research) Institut de Chimie Moléculaire de l'Université de Bourgogne, France
Université de Bourgogne, France
2022/09 - 2024/12/31 Researcher (Research) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal

Teaching in Higher Education

Category
Host institution
Employer
2024/10 - Current Tutor (University Teacher) Universidade da Beira Interior, Portugal
Universidade da Beira Interior, Portugal

Others

Category
Host institution
Employer
2025/01 - Current Research Fellow - CICS-UBI_BI_LABORATÓRIOS DE INVESTIGAÇÃO_2025 Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2023/11/17 - 2024/12/31 Research Fellow - UIDP/00709/2020 Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Projects

Contract

Designation Funders
2025/02 - Current Structural and cellular evaluation of G-quadruplex on B-MYB oncogene
2024.07170
Researcher
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal

Institut Européen de Chimie et Biologie, France
Fundação para a Ciência e a Tecnologia
Ongoing
2024/10 - Current AquaClean – Monitorização e remoção de disruptores endócrinos em águas superficiais
PL24-00059
Researcher
Universidade da Beira Interior FibEnTech Materiais Fibrosos e Tecnologias Ambientais, Portugal

Agência Portuguesa do Ambiente, Portugal

Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Fundação para a Ciência e a Tecnologia

Fundación Bancaria Caixa d'Estalvis i Pensions de Barcelona 'la Caixa'
Ongoing
2023/07 - 2024/06 Novel approach to control let-7e miRNA biogenesis: Unveiling the relationship between structure and function of let-7e precursor miRNA/nucleolin complex
APPID:2473
Researcher
Instruct-ERIC
Concluded
2024 - 2024 Collaborative Project Award PAPILOMA: Preclinical validation of a new gel vaginal prototype
UIDP/00709/2020
Researcher
Fundação para a Ciência e a Tecnologia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Lourenço, Pedro; Moreira, David; Alexandre, Daniela; Izamara Maocha; André Miranda; Lopes-Nunes, Jéssica; Cruz, Carla. Corresponding author: Cruz, Carla. "Therapeutic applications of nucleic acid aptamers". In Springer Handbook of Medical Biotechnology. 2025.
    Accepted
Conference abstract
  1. Lourenço, Pedro; André Miranda; Maria Paula Cabral Campello; António Paulo; Jean-Louis Mergny; Carla Cruz. "Selective Targeting of a B-MYB G-Quadruplex Motif with an Acridine-Based Nucleic Acid Probe". Paper presented in G4thering, Minneapolis, 2025.
    Accepted
  2. Lourenço, Pedro; André Miranda; Maria Paula Cabral Campello; António Paulo; Jean-Louis Mergny; Carla Patrícia Alves Freire Madeira Cruz. Corresponding author: Carla Patrícia Alves Freire Madeira Cruz. "MOLECULAR TARGETING OF A B-MYB G-QUADRUPLEX WITH AN ACRIDINE-BASED NUCLEIC ACID PROBE". Paper presented in Biophysics Festival 2025 - 5th Meeting of Young Biophysicists, Lisboa, 2025.
    Accepted
Conference poster
  1. Lourenço, Pedro; André Miranda; Maria Paula Cabral Campello; António Paulo; Jean Louis-Mergny; Cruz, Carla. "Estudo da formação de G4 no proto-oncogene B-MYB com uma sonda específica". Paper presented in ENCONTRO UBI CIÊNCIA E INOVAÇÃO 2024, 2024.
  2. Lourenço, Pedro; André Miranda; Maria Paula Cabral Campello; António Paulo; Jean-Louis Mergny; Cruz, Carla. "AVALIAÇÃO DA FORMAÇÃO DE G4 NO PROTO-ONCOGENE B-MYB". Paper presented in X Ciclo de Conferências da Faculdade de Ciências, 2024.
  3. Moreira, David; Lourenço, Pedro; André Miranda; Alexandre, Daniela; Pedro Baptista; Yi Lu; Cruz, Carla. "Microfluidics device based on molecular beacon beads to detect mir-155-3p". Paper presented in 3rd CNRS Workshop on Structural Biophysics, 2024.
  4. Lourenço, Pedro; André Miranda; Maria Paula Cabral Campello; António Paulo; Jean-Louis Mergny; Cruz, Carla. "Targeted probing of the G-quadruplex B-MYB forming motif using an acridine-nucleic acid probe". Paper presented in 3rd Workshop on Structural Biophysics, 2024.
  5. Moreira, David; Lourenço, Pedro; André Miranda; Daniela Alexandre; Pedro Baptista; Cândida Tomaz; Yi Lu; Cruz, Carla. "Mir-155-3p detection by molecular beacon bead-based assay". Paper presented in 4th Biophysics Festival, 2024.
  6. Lourenço, Pedro; André Miranda; Mergny, Jean-Louis; Cruz, Carla. Corresponding author: Lourenço, Pedro. "Interaction among G-Quadruplex forming sequences in B-MYB proto-oncogene with acridine derivative ligands". Paper presented in INTERACTION WINS 2023 - INnovative ThERApeutiC Targets In nOn-canonical Nucleic acids structures Winter InterNational School 2023, 2023.
  7. Lourenço, Pedro; André Miranda; Mergny, Jean-Louis; Cruz, Carla. "Evaluation of the interaction between acridine derivative ligands with G-Quadruplex forming sequences in B-MYB proto-oncogene". Paper presented in IV International Congress in Health Sciences Research, 2023.
Journal article
  1. Lourenço, Pedro; Moreira, David; Miranda, André; Lopes-Nunes, Jéssica; Maocha, Izamara; Santos, Tiago; Ferreira, Pedro L.; et al. Corresponding author: Cruz, Carla. "Exploring the G-Quadruplex Formation of AS1411 Derivatives". Molecules 30 8 (2025): 1673. https://doi.org/10.3390/molecules30081673.
    10.3390/molecules30081673
  2. Lourenço, Pedro; Cruz, Carla. "G-Quadruplex Conformational Switching for miR-155-3p Detection Using a Ligand-Based Fluorescence Approach". Biomolecules 15 3 (2025): 410. https://doi.org/10.3390/biom15030410.
    Published • 10.3390/biom15030410
  3. Figueiredo, Joana; Carreira-Barral, Israel; Lourenço, Pedro; Miranda, André; Lopes Nunes, Jéssica; Quesada, Roberto; Laranjo, Mafalda; Mergny, Jean-Louis; Cruz, Carla. "Synthesis of 1,10-phenanthroline-2,9-bistriazoles: Evaluation as G-quadruplex binders and anti-tumor activity". ChemMedChem (2024): http://dx.doi.org/10.1002/cmdc.202400591.
    10.1002/cmdc.202400591
  4. Moreira, David; Alexandre, Daniela; Miranda, André; Lourenço, Pedro; Baptista, Pedro V.; Tomaz, Cândida; Lu, Yi; Cruz, Carla. "Detecting mir-155-3p through a Molecular Beacon Bead-Based Assay". Molecules 29 13 (2024): 3182. http://dx.doi.org/10.3390/molecules29133182.
    10.3390/molecules29133182
  5. Gamboa, Joana; Lourenço, Pedro; Cruz, Carla; Gallardo, Eugenia. "Aptamers for the Delivery of Plant-Based Compounds: A Review". Pharmaceutics 16 4 (2024): 541. http://dx.doi.org/10.3390/pharmaceutics16040541.
    Published • 10.3390/pharmaceutics16040541
  6. Palma, Elisa; Içhedef, Cigdem; Fernandes, Célia; Belchior, Ana; Raposinho, Paula; Gano, Lurdes; Lourenço, Pedro; et al. "Targeting of G-quadruplex DNA with 99mTc(I)/Re(I) Tricarbonyl Complexes Carrying Pyridostatin Derivatives". Chemistry – A European Journal 30 22 (2024): https://doi.org/10.1002/chem.202400285.
    Published • 10.1002/chem.202400285
  7. Lourenço, Pedro; Miranda, André; Campello, Maria Paula Cabral; Paulo, António; Louis-Mergny, Jean; Cruz, Carla. Corresponding author: Cruz, Carla. "Targeting proto-oncogene B-MYB G-quadruplex with a nucleic acid–based fluorescent probe". International Journal of Biological Macromolecules 266 (2024): 131055. http://dx.doi.org/10.1016/j.ijbiomac.2024.131055.
    Published • 10.1016/j.ijbiomac.2024.131055
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/12/04 Are the G-quadruplexes real in the promoter region of B-MYB proto-oncogene? Lunch Seminar
CICS-UBI (Covilhã, Portugal)
2024/07/17 EVALUATION OF G4-FORMING MOTIF IN PRE-MIR150 XIX Annual CICS-UBI Symposium
CICS-UBI (Covilhã, Portugal)
2024/04/17 Exploring the structure and recognition of G-quadruplex in the promoter region of the B-MYB proto-oncogene SupraBio 2024, International Symposium on SupraBiomolecular Systems, 8th edition
Université de Bordeaux (Bordeaux, France)
2023/09/14 Non-canonical secondary structures in B-MYB proto-oncogene: a biophysical overview Bio3Pharm French-Portuguese Symposium
European Institute of Chemistry and Biology (IECB) (Bordeaux, France)
2023/07/11 Target Probing Of B-Myb G-Quadruplex With Acridine Ligands XVIII International CICS-UBI Symposium, 2023
Centro de Investigação em Ciências da Saúde (CICS) (Covilhã, Portugal)
2023/06/02 Biophysical characterization of the interaction between acridine-derivatives and g-quadruplex structures Biophysics Festival 2023
Portuguese Biophysics Society (Porto, Portugal)

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2025/03 - Current Exploring squaraine dyes as potential RNA- and DNA-based G-quadruplex ligands
Supervisor
Bioquímica (Degree)
Universidade da Beira Interior, Portugal
2024/03 - 2024/06 Avaliação in cell da formação de G-quadruplex em linhas celulares de cancro do pulmão de células não pequenas
Co-supervisor
Bioquímica (Degree)
Universidade da Beira Interior, Portugal

Event organisation

Event name
Type of event (Role)
Institution / Organization
2024/09 - 2025/07 Biophysics Festival 2025 - 5th Meeting of Young Biophysicists (2025/05/08 - 2025/05/09)
Meeting (Member of the Organising Committee)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Sociedade Portuguesa de Biofísica, Portugal

Sociedade Portuguesa de Bioquímica, Portugal
2024/05 - 2024/07 XIX Annual CICS-UBI Symposium (2024/07/16 - 2024/07/17)
Symposium (Member of the Organising Committee)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2024/06 - 2024/06 Theoretical Course: NMR for metabolic profiling (2024/06 - 2024/06)
Other (Member of the Organising Committee)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2023/09 - 2024/05 Biophysics Festival 2024 - 4th Meeting of Portuguese Young Biophysicists (2024/05/09 - 2024/05/10)
Meeting (Member of the Organising Committee)
Universidade da Beira Interior, Portugal

Sociedade Portuguesa de Biofísica, Portugal

Sociedade Portuguesa de Bioquímica, Portugal
2023/12 - 2023/12 3rd Edition Hands-on course NMR: from theory to practice (2023/12 - 2023/12)
Other (Member of the Organising Committee)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal

Event participation

Activity description
Type of event
Event name
Institution / Organization
2025/03/05 - 2025/03/05 Orador na Sessão de Esclarecimento dos Mestrados em Bioquímica-UBI
Round table
Sessão de Esclarecimento dos Mestrados em Bioquímica – UBI
Núcleo de Estudantes de Química da Universidade da Beira Interior, Portugal
2024/10/14 - 2024/10/18 3rd Workshop on Structural Biophysics
Workshop
3rd Workshop on Structural Biophysics
Institut Européen de Chimie et Biologie, France
2024/06/14 - 2024/06/14 SPME: Theory and Practice
Workshop
SPME: Theory and Practice
University of Waterloo, Canada

Jury of academic degree

Topic
Role
Candidate name (Type of degree)
Institution / Organization
2024/06 Desenvolvimento de uma nanopartícula lipídica para entrega direcionada de fármacos.
(Thesis) Main arguer
Inês Almeida (Other)
Universidade da Beira Interior, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2024/10 - Current Biochemistry I Bioquímica (Licenciatura) Universidade da Beira Interior, Portugal
2024 - Current Métodos Espectroscópicos Química Industrial (Mestrado) Universidade da Beira Interior, Portugal

Scientific expedition

Activity description Institution / Organization
2025/02/03 - 2025/03/03 Study of active regulatory regions of PD-L1 Institut de Chimie Moléculaire de l'Université de Bourgogne, France
Distinctions

Award

2025 G4thering 2025 Student Travel Grant
2025 Prémio de Inovação UBI-CGD 2024 - OralCare: Smart nanoparticle formulation to treat Human Papilloma Virus-induced oral lesions
Universidade da Beira Interior, Portugal